John Severinghaus, MD

Professor Emeritus
Bickler PE, Feiner JR, Lipnick MS, Batchelder P, MacLeod DB, Severinghaus JW. Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance. Anesth Analg. 2017 Jan; 124(1):146-153.
Severinghaus JW. Eight sages over five centuries share oxygen's discovery. Adv Physiol Educ. 2016 Sep; 40(3):370-6.
Severinghaus JW. The Most Important Discovery of Science. Adv Exp Med Biol. 2016; 876:1-16.
Severinghaus JW. HIGH LIFE: High altitude fatalities led to pulse oximetry. J Appl Physiol (1985). 2016 Jan 15; 120(2):236-43.
Severinghaus JW. Crediting six discoverers of oxygen. Adv Exp Med Biol. 2014; 812:9-17.
Severinghaus JW. Career perspective: John W. Severinghaus. Extrem Physiol Med. 2013; 2:29.
Severinghaus JW. Monitoring oxygenation. J Clin Monit Comput. 2011 Jun; 25(3):155-61.
Severinghaus JW. Unfinished physiology. Adv Exp Med Biol. 2010; 662:3-5.
Severinghaus JW. Gadgeteering for health care: the John W. Severinghaus lecture on translational science. Anesthesiology. 2009 Apr; 110(4):721-8.
Severinghaus JW. History of measuring O2 and CO2 responses. Adv Exp Med Biol. 2008; 605:3-8.
Severinghaus JW. Sensitivity of cerebral blood flow to hypoxia and hypoxic hypocapnia in Ethiopian highlanders. High Alt Med Biol. 2008; 9(4):345-6; author reply 347.
Severinghaus JW. Takuo Aoyagi: discovery of pulse oximetry. Anesth Analg. 2007 Dec; 105(6 Suppl):S1-4, tables of contents.
Feiner JR, Severinghaus JW, Bickler PE. Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender. Anesth Analg. 2007 Dec; 105(6 Suppl):S18-23, tables of contents.
Severinghaus JW. Mass law predicts hyperbolic hypoxic ventilatory response. Adv Exp Med Biol. 2006; 578:41-8.
Kagawa S, Severinghaus JW. Errors in monitoring transcutaneous PCO2 on the ear. Crit Care Med. 2005 Oct; 33(10):2414-5.
Bickler PE, Feiner JR, Severinghaus JW. Effects of skin pigmentation on pulse oximeter accuracy at low saturation. Anesthesiology. 2005 Apr; 102(4):715-9.
Mansoor JK, Morrissey BM, Walby WF, Yoneda KY, Juarez M, Kajekar R, Severinghaus JW, Eldridge MW, Schelegle ES. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt Med Biol. 2005; 6(4):289-300.
Severinghaus JW. The Rahn-Otis discovery of hypoxic ventilatory decline. High Alt Med Biol. 2005; 6(4):339-41.
Kagawa S, Otani N, Kamide M, Gisiger PA, Eberhard P, Severinghaus JW. Initial transcutaneous PCO2 overshoot with ear probe at 42 degrees C. J Clin Monit Comput. 2004 Dec; 18(5-6):343-5.
Severinghaus JW. First electrodes for blood PO2 and PCO2 determination. J Appl Physiol (1985). 2004 Nov; 97(5):1599-600.
Severinghaus JW. Continuous positive airway pressure, shock therapy, and gastric mucosal oxygenation. Crit Care Med. 2003 Jun; 31(6):1870-1.
Severinghaus JW. Fire-air and dephlogistication. Revisionisms of oxygen's discovery. Adv Exp Med Biol. 2003; 543:7-19.
Severinghaus JW. The invention and development of blood gas analysis apparatus. Anesthesiology. 2002 Jul; 97(1):253-6.
Severinghaus JW. Priestley, the furious free thinker of the enlightenment, and Scheele, the taciturn apothecary of Uppsala. Acta Anaesthesiol Scand. 2002 Jan; 46(1):2-9.
Severinghaus JW. Stumbling over a bias. What happens to spinal fluid pH at high altitude? Am J Respir Crit Care Med. 2000 Jan; 161(1):3-4.
Severinghaus JW. Paradoxical relation of mitochondrial PO2 to Vo2. Adv Exp Med Biol. 1999; 471:595-604.
Severinghaus J, Astrup P. pH and acid-base balance measurements. 1987. Int Anesthesiol Clin. 1999; 37(1):55-86.
Severinghaus JW. A tribute to Niels Lassen. December 7th, 1926--April 30th, 1997. Adv Exp Med Biol. 1999; 474:355-8.
Gregory GA, Feiner J, Severinghaus JW. Tidal volume, PaCO2, and lung injury. Crit Care Med. 1998 Oct; 26(10):1632-3.
Severinghaus JW. Hans Loeschcke, Robert Mitchell and the medullary CO2 chemoreceptors: a brief historical review. Respir Physiol. 1998 Oct; 114(1):17-24.
Severinghaus JW. Endotoxin hyperventilation mechanisms. Crit Care Med. 1998 Sep; 26(9):1481-2.
Xu F, Severinghaus JW. Rat brain VEGF expression in alveolar hypoxia: possible role in high-altitude cerebral edema. J Appl Physiol (1985). 1998 Jul; 85(1):53-7.
Schlichtig R, Grogono AW, Severinghaus JW. Human PaCO2 and standard base excess compensation for acid-base imbalance. Crit Care Med. 1998 Jul; 26(7):1173-9.
Severinghaus JW, Astrup P, Murray JF. Blood gas analysis and critical care medicine. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 2):S114-22.
Severinghaus JW. Uses of high altitude for studies of effects of hypoxia. Adv Exp Med Biol. 1998; 454:17-28.
Severinghaus JW. Intrathecally, Caine may dis-Able. Reflections on lidocaine for spinal anesthesia. Acta Anaesthesiol Scand Suppl. 1998; 113:3-7.
Xu F, Severinghaus JW. Expression and response to hypoxia of vascular endothelial growth factor (VEGF) in rat and rabbit tissues. Adv Exp Med Biol. 1998; 454:311-7.
Severinghaus JW. pH change in tissue can be detected using infra-red light reflectance spectroscopy. J Clin Monit. 1997 Jul; 13(4):279-80.
Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Severinghaus JW, Wagner PD. Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. J Appl Physiol (1985). 1996 Aug; 81(2):922-32.
Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J Appl Physiol (1985). 1996 Aug; 81(2):911-21.
Jensen JB, Sperling B, Severinghaus JW, Lassen NA. Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude. J Appl Physiol (1985). 1996 Apr; 80(4):1214-8.
Jerome EH, Severinghaus JW. High-altitude pulmonary edema. N Engl J Med. 1996 Mar 07; 334(10):662-3.
Vaagenes P, Ginsberg M, Ebmeyer U, Ernster L, Fischer M, Gisvold SE, Gurvitch A, Hossmann KA, Nemoto EM, Radovsky A, Severinghaus JW, Safar P, Schlichtig R, Sterz F, Tonnessen T, White RJ, Xiao F, Zhou Y. Cerebral resuscitation from cardiac arrest: pathophysiologic mechanisms. Crit Care Med. 1996 Feb; 24(2 Suppl):S57-68.
Shoemaker WC, Peitzman AB, Bellamy R, Bellomo R, Bruttig SP, Capone A, Dubick M, Kramer GC, McKenzie JE, Pepe PE, Safar P, Schlichtig R, Severinghaus JW, Tisherman SA, Wiklund L. Resuscitation from severe hemorrhage. Crit Care Med. 1996 Feb; 24(2 Suppl):S12-23.
Bellamy R, Safar P, Tisherman SA, Basford R, Bruttig SP, Capone A, Dubick MA, Ernster L, Hattler BG, Hochachka P, Klain M, Kochanek PM, Kofke WA, Lancaster JR, McGowan FX, Oeltgen PR, Severinghaus JW, Taylor MJ, Zar H. Suspended animation for delayed resuscitation. Crit Care Med. 1996 Feb; 24(2 Suppl):S24-47.
Severinghaus JW. Discrepancy between evidence and theory of myoglobin SO2 in work. Adv Exp Med Biol. 1996; 388:237-40.
Severinghaus JW. Hypothetical roles of angiogenesis, osmotic swelling, and ischemia in high-altitude cerebral edema. J Appl Physiol (1985). 1995 Aug; 79(2):375-9.
Feiner JR, Bickler PE, Severinghaus JW. Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol. 1995 Jun; 100(3):213-22.
Severinghaus JW. Hypoxic ventilatory depression may be due to central chemoreceptor cell hyperpolarization. Adv Exp Med Biol. 1995; 393:257-60.
Severinghaus JW. Hypothesis: angiogenesis cytokines in high altitude cerebral oedema. Acta Anaesthesiol Scand Suppl. 1995; 107:177-8.
Severinghaus JW. Exercise O2 transport model assuming zero cytochrome PO2 at VO2 max. J Appl Physiol (1985). 1994 Aug; 77(2):671-8.
Sato M, Severinghaus JW, Bickler P. Time course of augmentation and depression of hypoxic ventilatory responses at altitude. J Appl Physiol (1985). 1994 Jul; 77(1):313-6.
Severinghaus JW. Nomenclature of oxygen saturation. Adv Exp Med Biol. 1994; 345:921-3.
Severinghaus JW. Invited editorial on "Widespread sites of brain stem ventilatory chemoreceptors". J Appl Physiol (1985). 1993 Jul; 75(1):3-4.
Eriksson LI, Sato M, Severinghaus JW. Effect of a vecuronium-induced partial neuromuscular block on hypoxic ventilatory response. Anesthesiology. 1993 Apr; 78(4):693-9.
Severinghaus JW. Siggaard-Andersen and the "Great Trans-Atlantic Acid-Base Debate". Scand J Clin Lab Invest Suppl. 1993; 214:99-104.
Severinghaus JW. History and recent developments in pulse oximetry. Scand J Clin Lab Invest Suppl. 1993; 214:105-11.
Xu F, Sato M, Spellman MJ, Mitchell RA, Severinghaus JW. Topography of cat medullary ventral surface hypoxic acidification. J Appl Physiol (1985). 1992 Dec; 73(6):2631-7.
Sato M, Severinghaus JW, Powell FL, Xu FD, Spellman MJ. Augmented hypoxic ventilatory response in men at altitude. J Appl Physiol (1985). 1992 Jul; 73(1):101-7.
Sato M, Severinghaus JW, Basbaum AI. Medullary CO2 chemoreceptor neuron identification by c-fos immunocytochemistry. J Appl Physiol (1985). 1992 Jul; 73(1):96-100.
Severinghaus JW, Kelleher JF. Recent developments in pulse oximetry. Anesthesiology. 1992 Jun; 76(6):1018-38.
Xu FD, Spellman MJ, Sato M, Baumgartner JE, Ciricillo SF, Severinghaus JW. Anomalous hypoxic acidification of medullary ventral surface. J Appl Physiol (1985). 1991 Dec; 71(6):2211-7.
Severinghaus JW. Acid-base balance controversy. Editorial introduction. J Clin Monit. 1991 Jul; 7(3):274-5.
Bissonnette B, Bickler PE, Gregory GA, Severinghaus JW. Intracranial pressure and brain redox balance in rabbits. Can J Anaesth. 1991 Jul; 38(5):654-9.
Severinghaus JW. Acid-base balance controversy. Case for standard-base excess as the measure of nonrespiratory acid-base imbalance. J Clin Monit. 1991 Jul; 7(3):276-7.
Severinghaus JW, Xu FD, Spellman MJ. Benzocaine and methemoglobin: recommended actions. Anesthesiology. 1991 Feb; 74(2):385-7.
Koh SO, Severinghaus JW. Effect of halothane on hypoxic and hypercapnic ventilatory responses of goats. Br J Anaesth. 1990 Nov; 65(5):713-7.
Severinghaus JW, Spellman MJ. Pulse oximeter failure thresholds in hypotension and vasoconstriction. Anesthesiology. 1990 Sep; 73(3):532-7.
Palmisano BW, Severinghaus JW. Transcutaneous PCO2 and PO2: a multicenter study of accuracy. J Clin Monit. 1990 Jul; 6(3):189-95.
Wimberley PD, Siggaard-Andersen O, Fogh-Andersen N, Zijlstra WG, Severinghaus JW. Haemoglobin oxygen saturation and related quantities: definitions, symbols and clinical use. Scand J Clin Lab Invest. 1990 Jun; 50(4):455-9.
Severinghaus JW, Koh SO. Effect of anemia on pulse oximeter accuracy at low saturation. J Clin Monit. 1990 Apr; 6(2):85-8.
Cohen Y, Chang LH, Litt L, Kim F, Severinghaus JW, Weinstein PR, Davis RL, Germano I, James TL. Stability of brain intracellular lactate and 31P-metabolite levels at reduced intracellular pH during prolonged hypercapnia in rats. J Cereb Blood Flow Metab. 1990 Mar; 10(2):277-84.
Severinghaus JW. What's new with CO2? Acta Anaesthesiol Scand Suppl. 1990; 94:13-7.
Bickler PE, Koh SO, Severinghaus JW. Effects of hypoxia and hypocapnia on brain redox balance in ducks. Am J Physiol. 1989 Jul; 257(1 Pt 2):R132-5.
Severinghaus JW. Water vapor calibration errors in some capnometers: respiratory conventions misunderstood by manufacturers? Anesthesiology. 1989 Jun; 70(6):996-8.
Severinghaus JW. Carotid body resection for COPD? Chest. 1989 May; 95(5):1128-9.
Naifeh KH, Severinghaus JW, Kamiya J, Krafft M. Effect of aging on estimates of hypercapnic ventilatory response during sleep. J Appl Physiol (1985). 1989 Apr; 66(4):1956-64.
Severinghaus JW, Naifeh KH, Koh SO. Errors in 14 pulse oximeters during profound hypoxia. J Clin Monit. 1989 Apr; 5(2):72-81.
Abramson NS, Detre K, Bradley K, Kelsey SF, Ricci E, Safar P, Severinghaus JW, Shuman LJ, Stewart RD. Impact evaluation in resuscitation research: discussion of clinical trials. Crit Care Med. 1988 Oct; 16(10):1053-8.
Severinghaus JW. Zen and the art of brain maintenance. Crit Care Med. 1988 Oct; 16(10):1019-21.
Jaffe GJ, Irvine AR, Wood IS, Severinghaus JW, Pino GR, Haugen C. Retinal phototoxicity from the operating microscope. The role of inspired oxygen. Ophthalmology. 1988 Aug; 95(8):1130-41.
Bickler PE, Litt L, Banville DL, Severinghaus JW. Effects of acetazolamide on cerebral acid-base balance. J Appl Physiol (1985). 1988 Jul; 65(1):422-7.
Bickler PE, Litt L, Severinghaus JW. Effects of acetazolamide on cerebrocortical NADH and blood volume. J Appl Physiol (1985). 1988 Jul; 65(1):428-33.
Severinghaus JW. [Pulse oximetry: a revolution in anesthesiology]. Rev Esp Anestesiol Reanim. 1988 May-Jun; 35(3):119-20.
Naifeh KH, Severinghaus JW. Validation of a maskless CO2-response test for sleep and infant studies. J Appl Physiol (1985). 1988 Jan; 64(1):391-6.
Severinghaus JW. [Status of the development of blood gas electrodes: Dr. J. W. Severinghaus interviewed by K. Suwa]. Kokyu To Junkan. 1987 Dec; 35(12):1227-32.
Severinghaus JW, Naifeh KH. Accuracy of response of six pulse oximeters to profound hypoxia. Anesthesiology. 1987 Oct; 67(4):551-8.
Litt L, González-Méndez R, James TL, Sessler DI, Mills P, Chew W, Moseley M, Pereira B, Severinghaus JW, Hamilton WK. An in vivo study of halothane uptake and elimination in the rat brain with fluorine nuclear magnetic resonance spectroscopy. Anesthesiology. 1987 Aug; 67(2):161-8.
Severinghaus JW, Honda Y. History of blood gas analysis. VII. Pulse oximetry. J Clin Monit. 1987 Apr; 3(2):135-8.
Severinghaus JW. Continuous monitoring of alveolar and inspiratory concentrations of anesthetic and respiratory gases is safe, simple, and cost-effective. J Clin Monit. 1987 Apr; 3(2):123.
Naifeh KH, Severinghaus JW, Kamiya J. Effect of aging on sleep-related changes in respiratory variables. Sleep. 1987 Apr; 10(2):160-71.
Severinghaus JW. Hypocapnia on ventral medullary blood flow and pH during hypoxia. J Appl Physiol (1985). 1987 Feb; 62(2):850-1.
Severinghaus JW, Honda Y. Pulse oximetry. Int Anesthesiol Clin. 1987; 25(4):205-14.
Severinghaus JW, Astrup PB. History of blood gas analysis. Int Anesthesiol Clin. 1987; 25(4):1-224.
Severinghaus JW. History, status and future of pulse oximetry. Adv Exp Med Biol. 1987; 220:3-8.
Severinghaus JW, Astrup PB. History of blood gas analysis. VI. Oximetry. J Clin Monit. 1986 Oct; 2(4):270-88.
Severinghaus JW, Young WG. A gas mixer for computer calibration of an anesthetic mass spectrometer. J Clin Monit. 1986 Oct; 2(4):223-9.
Litt L, González-Méndez R, Weinstein PR, Severinghaus JW, Hamilton WK, Shuleshko J, Murphy-Boesch J, James TL. An in vivo 31P NMR study of cerebral hypoxic hypoxia in rats. Magn Reson Med. 1986 Aug; 3(4):619-25.
Severinghaus JW, Astrup PB. History of blood gas analysis. V. Oxygen measurement. J Clin Monit. 1986 Jul; 2(3):174-89.
Litt L, González-Méndez R, Severinghaus JW, Hamilton WK, Rampil IJ, Shuleshko J, Murphy-Boesch J, James TL. Cerebral intracellular ADP concentrations during hypercarbia: an in vivo 31P nuclear magnetic resonance study in rats. J Cereb Blood Flow Metab. 1986 Jun; 6(3):389-92.
Severinghaus JW, Astrup PB. History of blood gas analysis. IV. Leland Clark's oxygen electrode. J Clin Monit. 1986 Apr; 2(2):125-39.
Severinghaus JW, Astrup PB. History of blood gas analysis. III. Carbon dioxide tension. J Clin Monit. 1986 Jan; 2(1):60-73.
Levy R, Feustel P, Severinghaus J, Hosobuchi Y. Focal cerebral ischemia in the cat: effect of naloxone on cortical blood flow and neurological deficit following middle cerebral artery occlusion. Bull Clin Neurosci. 1986; 51:94-101.
Litt L, González-Méndez R, Severinghaus JW, Hamilton WK, Shuleshko J, Murphy-Boesch J, James TL. Cerebral intracellular changes during supercarbia: an in vivo 31P nuclear magnetic resonance study in rats. J Cereb Blood Flow Metab. 1985 Dec; 5(4):537-44.
Severinghaus JW, Astrup PB. History of blood gas analysis. II. pH and acid-base balance measurements. J Clin Monit. 1985 Oct; 1(4):259-77.
Severinghaus JW, Astrup PB. History of blood gas analysis. I. The development of electrochemistry. J Clin Monit. 1985 Jul; 1(3):180-92.
Hazinski TA, Severinghaus JW, Marin MS, Tooley WH. Estimation of ventilatory response to carbon dioxide in newborn infants using skin surface blood gas electrodes. J Pediatr. 1984 Sep; 105(3):389-93.
Feustel PJ, Stafford MJ, Allen JS, Severinghaus JW. Ventrolateral medullary surface blood flow determined by hydrogen clearance. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan; 56(1):150-4.
Vurek GG, Feustel PJ, Severinghaus JW. A fiber optic PCO2 sensor. Ann Biomed Eng. 1983; 11(6):499-510.
Levy R, Feustel P, Severinghaus J, Hosobuchi Y. Effect of naloxone on neurologic deficit and cortical blood flow during focal cerebral ischemia in cats. Life Sci. 1982 Nov 15-22; 31(20-21):2205-8.
Cahalan MK, Johnson BH, Eger EI, Sheiner LB, Richardson CA, Varner JK, Severinghaus JW. A noninvasive in vivo method of assessing the kinetics of halothane metabolism in humans. Anesthesiology. 1982 Oct; 57(4):298-302.
Hazinski TA, Severinghaus JW. Transcutaneous analysis of arterial PCO2. Med Instrum. 1982 May-Jun; 16(3):150-3.
Kagawa S, Stafford MJ, Waggener TB, Severinghaus JW. No effect of naloxone on hypoxia-induced ventilatory depression in adults. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr; 52(4):1030-4.
Feustel PJ, Ingvar MC, Severinghaus JW. Cerebral oxygen availability and blood flow during middle cerebral artery occlusion: effects of pentobarbital. Stroke. 1981 Nov-Dec; 12(6):858-63.
Ozanne GM, Young WG, Mazzei WJ, Severinghaus JW. Multipatient anesthetic mass spectrometry: rapid analysis of data stored in long catheters. Anesthesiology. 1981 Jul; 55(1):62-70.
Irsigler GB, Stafford MJ, Severinghaus JW. Relationship of CSF pH, O2, and CO2 responses in metabolic acidosis and alkalosis in humans. J Appl Physiol Respir Environ Exerc Physiol. 1980 Feb; 48(2):355-61.
Irsigler GB, Severinghaus JW. Clinical problems of ventilatory control. Annu Rev Med. 1980; 31:109-26.
Severinghaus JW, Crawford R, Irsigler G, Stafford MJ. [The role of the carotid bodies to respiratory regulation studied by altitude acclimatization, metabolic acidosis and denervation (author's transl)]. Kokyu To Junkan. 1980 Jan; 28(1):25-7.
Severinghaus JW. Pathophysiologic aspects of the regulation of respiration. Bull Mem Acad R Med Belg. 1979 May 19; 134(5):261-71.
Honda Y, Myojo S, Hasegawa S, Hasegawa T, Severinghaus JW. Decreased exercise hyperpnea in patients with bilateral carotid chemoreceptor resection. J Appl Physiol Respir Environ Exerc Physiol. 1979 May; 46(5):908-12.
Honda Y, Watanabe S, Hashizume I, Satomura Y, Hata N, Sakakibara Y, Severinghaus JW. Hypoxic chemosensitivity in asthmatic patients two decades after carotid body resection. J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr; 46(4):632-8.
Piernan S, Roizen MF, Severinghaus JW. Oxygen analyzer dangerous--senses nitrous oxide as battery fails. Anesthesiology. 1979 Feb; 50(2):146-9.
Severinghaus JW, Bradley AF, Stafford MJ. Transcutaneous PCO2 electrode design with internal silver heat path. Birth Defects Orig Artic Ser. 1979; 15(4):265-70.
Peabody JL, Willis MM, Gregory GA, Severinghaus JW. Reliability of skin (tc)PO2 electrode heating power as a continuous noninvasive monitor of mean arterial pressure in sick newborns. Birth Defects Orig Artic Ser. 1979; 15(4):127-33.
Severinghaus JW. Current trends in continuous blood gas monitoring. Biotelem Patient Monit. 1979; 6(1-2):9-15.
Versmold HT, Tooley WH, Severinghaus JW. Increase of skin O2 diffusion resistance with birthweight. Birth Defects Orig Artic Ser. 1979; 15(4):271-2.
Crawford RD, Severinghaus JW. CSF pH and ventilatory acclimatization to altitude. J Appl Physiol Respir Environ Exerc Physiol. 1978 Aug; 45(2):275-83.
Severinghaus JW, Crawford RD. Carotid chemoreceptor role in CSF alkalosis at altitude. Chest. 1978 Feb; 73(2 Suppl):249-51.
Severinghaus JW, Stafford M, Bradley AF. tcPCO2 electrode design, calibration and temperature gradient problems. Acta Anaesthesiol Scand Suppl. 1978; 68:118-22.
Peabody JL, Willis MM, Severinghaus JW. Characteristics of non-aqueous electrolytes for transcutaneous oxygen electrodes. Acta Anaesthesiol Scand Suppl. 1978; 68:49-54.
Severinghaus JW, Peabody JL, Thunström AM, Stafford M. Transcutaneous oxygen measurements: calibration analysis and electrode stabilization methods. Acta Anaesthesiol Scand Suppl. 1978; 70:180-2.
Severinghaus JW. Alkaline chloride-free oxygen electrolytes. Acta Anaesthesiol Scand Suppl. 1978; 68:73-5.
Thunstrom AM, Severinghaus JW. The use of concentrated NaNO3 in tcPO2 electrodes to diminish O2 consumption and dehydration drift. Acta Anaesthesiol Scand Suppl. 1978; 68:55-62.
Severinghaus JW, Ozanne G. Multioperating room monitoring with one mass spectrometer. Acta Anaesthesiol Scand Suppl. 1978; 70:186-7.
Eberhard P, Severinghaus JW. Measurement of heated skin O2 diffusion conductance and PO2 sensor induced O2 gradient. Acta Anaesthesiol Scand Suppl. 1978; 68:1-3.
Severinghaus JW, Thunstrom A. Problems of calibration and stabilization of tcPO2 electrodes. Acta Anaesthesiol Scand Suppl. 1978; 68:68-72.
Severinghaus JW, Ozanne GM, Louderbough H. Measurement of lung weight and cardiac output by single breath and rebreathing methods with a mass spectrometer. Acta Anaesthesiol Scand Suppl. 1978; 70:161-4.
Severinghaus JW, Crawford RD. Carotid chemoreceptor role in CSF alkalosis at altitude. Adv Exp Med Biol. 1978; 99:163-72.
Overland ES, Severinghaus JW. Noncardiac pulmonary edema. Adv Intern Med. 1978; 23:307-26.
Severinghaus JW, Stafford M, Thunstrom AM. Estimation of skin metabolism and blood flow with tcPO2 and tcPO2 electrodes by cuff occlusion of the circulation. Acta Anaesthesiol Scand Suppl. 1978; 68:9-15.
Severinghaus JW, Crawford RD. Regulation of respiration. Acta Anaesthesiol Scand Suppl. 1978; 70:188-91.
Berger AJ, Mitchell RA, Severinghaus JW. Regulation of respiration (third of three parts). N Engl J Med. 1977 Jul 28; 297(4):194-201.
Berger AJ, Mitchell RA, Severinghaus JW. Regulation of respiration: (second of three parts). N Engl J Med. 1977 Jul 21; 297(3):138-43.
Berger AJ, Mitchell RA, Severinghaus JW. Regulation of respiration (first of three parts). N Engl J Med. 1977 Jul 14; 297(2):92-7.
Severinghaus JW. Pulmonary vascular function. Am Rev Respir Dis. 1977 Jun; 115(6 Pt 2):149-58.
Severinghaus JW. Reye's Syndrome and Ondine's Curse. West J Med. 1977 Feb; 126(2):137-8.
Cherniack NS, Dempsey J, Fencl V, Fitzgerald RS, Lourenço RV, Rebuck AS, Rigg J, Severinghaus JW, Weil JW, Whitelaw WA, Zwilich CW. Workshop on assessment of respiratory control in humans. I. Methods of measurement of ventilatory responses to hypoxia and hypercapnia. Am Rev Respir Dis. 1977 Jan; 115(1):177-81.
Severinghaus JW. Acid-base balance nomogram--a Boston-Copenhagen detente. Anesthesiology. 1976 Nov; 45(5):539-41.
Severinghaus JW. Editorial: Chemical regulation of ventilation: who needs it? N Engl J Med. 1976 Oct 14; 295(16):895-6.
Severinghaus J, Ozanne G, Massuda Y. Measurement of the ventilatory response to hypoxia. A step hypoxia three-minute test. Chest. 1976 Jul; 70(1 Suppl):121-4.
Severinghaus JW. Proposed standard determination of ventilatory responses to hypoxia and hypercapnia in man. Chest. 1976 Jul; 70(1 Suppl):129-31.
Becker LD, Paulson BA, Miller RD, Severinghaus JW, Eger EI. Biphasic respiratory depression after fentanyldroperidol or fentanyl alone used to supplement nitrous oxide anesthesia. Anesthesiology. 1976 Apr; 44(4):291-6.
Severinghaus JW. Analog computer for base excess and HCO3-from pH and PCO2 electrodes. IEEE Trans Biomed Eng. 1976 Jan; 23(1):77-81.
Kronenberg RS, Gabel RA, Severinghaus JW. Normal chemoreceptor function in obesity before and after ileal bypass surgery to force weight reduction. Am J Med. 1975 Sep; 59(3):349-53.
Weiskopf RB, Raymond LW, Severinghaus JW. Effects of halothane on canine respiratory responses to hypoxia with and without hypercarbia. Anesthesiology. 1974 Oct; 41(4):350-60.
Sorensen SC, Lassen NA, Severinghaus JW, Coudert J, Zamora MP. Cerebral glucose metabolism and cerebral blood flow in high-altitude residents. J Appl Physiol. 1974 Sep; 37(3):305-10.
Nemoto EM, Hoff JT, Severinghaus JW. Lactate uptake and metabolism by brain during hyperlactatemia and hypoglycemia. Stroke. 1974 Jan-Feb; 5(1):48-53.
Nemoto EM, Severinghaus JW. Stereospecific permeability of rat blood-brain barrier to lactic acid. Stroke. 1974 Jan-Feb; 5(1):81-4.
Gabel RA, Kronenberg RS, Severinghaus JW. Vital capacity breaths of 5 percent or 15 percent CO 2 in N 2 or O 2 to test carotid chemosensitivity. Respir Physiol. 1973 Mar; 17(2):195-208.
Safar P, Nemoto EM, Severinghaus JW. Pathogenesis of central nervous system disorder during artificial hyperventilation in compensated hypercarbia in dogs. Crit Care Med. 1973 Jan-Feb; 1(1):5-16.
Kronenberg R, Hamilton FN, Gabel R, Hickey R, Read DJ, Severinghaus J. Comparison of three methods for quantitating respiratory response to hypoxia in man. Respir Physiol. 1972 Sep; 16(1):109-25.
Weiskopf RB, Severinghaus JW. Lack of effect of high altitude on hemoglobin oxygen affinity. J Appl Physiol. 1972 Aug; 33(2):276-7.
Severinghaus JW. Symposium on the anesthetist and the lung. Anesthesiology. 1972 May; 36(5):523-5.
Severinghaus JW. International symposium on cerebral blood flow regulation, acid-base and energy metabolism in acute brain injuries. Anesthesiology. 1972 Apr; 36(4):414-6.
Weiskopf RB, Severinghaus JW. Diffusing capacity of the lung for CO in man during acute acclimation to 14,246 ft. J Appl Physiol. 1972 Mar; 32(3):285-9.
Severinghaus JW. Per cent pH regulation as an index of CO2 buffering in vivo and in vitro. Scand J Clin Lab Invest. 1972; 29(4):467-8.
Weiskopf RB, Nishimura M, Severinghaus JW. The absence of an effect of halothane on blood hemoglobin O 2 equilibrium in vitro. Anesthesiology. 1971 Dec; 35(6):579-81.
Raymond L, Severinghaus JW. Static pulmonary compliance of man during altitude hypoxia. J Appl Physiol. 1971 Nov; 31(5):785-7.
Kronenberg RS, Safar P, Wright F, Noble W, Wahrenbrock E, Hickey R, Nemoto E, Severinghaus JW. Pulmonary artery pressure and alveolar gas exchange in man during acclimatization to 12,470 ft. J Clin Invest. 1971 Apr; 50(4):827-37.
Severinghaus JW, Nemoto E, Hoff J. The CO 2 shuttle in cerebral arteriolar ECF H control. Eur Neurol. 1971-1972; 6(1):56-9.
Wahrenbrock EA, Carrico CJ, Amundsen DA, Trummer MJ, Severinghaus JW. Increased atelectatic pulmonary shunt during hemorrhagic shock in dogs. J Appl Physiol. 1970 Nov; 29(5):615-21.
Bainton CR, Severinghaus JW. Modification of the radiometer BMS-3 electrode system to improve thermal stability. Anesthesiology. 1970 Nov; 33(5):548-50.
Sorensen SC, Severinghaus JW. Effect of cerebral acidosis on the CSF-blood potential difference. Am J Physiol. 1970 Jul; 219(1):68-71.
Wade JG, Larson CP, Hickey RF, Ehrenfeld WK, Severinghaus JW. Effect of carotid endarterectomy on carotid chemoreceptor and baroreceptor function in man. N Engl J Med. 1970 Apr 09; 282(15):823-9.
Ehrenfeld WK, Hamilton FN, Larson CP, Hickey RF, Severinghaus JW. Effect of CO2 and systemic hypertension on downstream cerebral arterial pressure during carotid endarterectomy. Surgery. 1970 Jan; 67(1):87-96.
Cullen DJ, Cotev S, Severinghaus JW, Eger EI. The effects of hypoxia and isovolemic anemia on the halothane requirement (MAC) of dogs. II. The effects of acute hypoxia on halothane requirement and cerebral-surface Po2, Pco2, pH and HCO3. Anesthesiology. 1970 Jan; 32(1):35-45.
Hornbein TF, Severinghaus JW. Carotid chemoreceptor response to hypoxia and acidosis in cats living at high altitude. J Appl Physiol. 1969 Dec; 27(6):837-9.
Severinghaus JW, Hamilton FN, Cotev S. Carbonic acid production and the role of carbonic anhydrase in decarboxylation in brain. Biochem J. 1969 Oct; 114(4):703-5.
Eisele JH, Pegg J, Severinghaus JW. Ventilatory response to hypoxia in acutely polycythemic dogs. J Appl Physiol. 1969 Jun; 26(6):757-9.
Cotev S, Severinghaus JW. Role of cerebrospinal fluid pH in management of respiratory problems. Anesth Analg. 1969 Jan-Feb; 48(1):42-7.
Whayne TF, Severinghaus JW. Experimental hypoxic pulmonary edema in the rat. J Appl Physiol. 1968 Dec; 25(6):729-32.
Sorensen SC, Severinghaus JW. Irreversible respiratory insensitivity to acute hypoxia in man born at high altitude. J Appl Physiol. 1968 Sep; 25(3):217-20.
Sorensen SC, Severinghaus JW. Respiratory sensitivity to acute hypoxia in man born at sea level living at high altitude. J Appl Physiol. 1968 Sep; 25(3):211-6.
Sorensen SC, Severinghaus JW. Respiratory insensitivity to acute hypoxia persisting after correction of tetralogy of Fallot. J Appl Physiol. 1968 Sep; 25(3):221-3.
Cotev S, Lee J, Severinghaus JW. The effects of acetazolamide on cerebral blood flow and cerebral tissue PO2. Anesthesiology. 1968 May-Jun; 29(3):471-7.
Severinghaus JW. Measurements of blood gases: PO2 and PCO2. Ann N Y Acad Sci. 1968 Feb 01; 148(1):115-32.
Severinghaus JW. Outline of H plus-blood flow relationships in brain. Scand J Clin Lab Invest Suppl. 1968; 102:VIII:K.
Severinghaus JW, Lassen NA. Cerebral blood flow control by arterial and not by tissue pCO2 as evidenced from CBF changes after step hypocapnia. Scand J Clin Lab Invest Suppl. 1968; 102:VII:B.
Cotev S, Cullen D, Severinghaus J. Cerebral ECF acidosis induced by hypoxia at normal and low pCO2. Scand J Clin Lab Invest Suppl. 1968; 102:III:E.
Severinghaus JW, Cotev S. Carbonic acidosis and cerebral vasodilation after Diamox. Scand J Clin Lab Invest Suppl. 1968; 102:I:E.
Eisele JH, Ritchie BC, Severinghaus JW. Effect of stellate ganglion blockade on the hyperpnea of exercise. J Appl Physiol. 1967 May; 22(5):966-9.
Severinghaus JW, Lassen N. Step hypocapnia to separate arterial from tissue PCO2 in the regulation of cerebral blood flow. Circ Res. 1967 Feb; 20(2):272-8.
Severinghaus JW, Chiodi H, Eger EI, Brandstater B, Hornbein TF. Cerebral blood flow in man at high altitude. Role of cerebrospinal fluid pH in normalization of flow in chronic hypocapnia. Circ Res. 1966 Aug; 19(2):274-82.
Eger EI, Babad AA, Regan MJ, Larson CP, Shargel R, Severinghaus JW. Delayed approach of arterial to alveolar nitrous oxide partial pressures in dog and in man. Anesthesiology. 1966 May-Jun; 27(3):288-97.
Severinghaus JW. Blood gas calculator. J Appl Physiol. 1966 May; 21(3):1108-16.
Naeraa N, Petersen ES, Boye E, Severinghaus JW. pH and molecular CO2 components of the Bohr effect in human blood. Scand J Clin Lab Invest. 1966; 18(1):96-102.
Severinghaus JW, Bainton CR, Carcelen A. Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir Physiol. 1966; 1(3):308-34.
Eger EI, Brandstater B, Saidman LJ, Regan MJ, Severinghaus JW, Munson ES. Equipotent alveolar concentrations of methoxyflurane, halothane, diethyl ether, fluroxene, cyclopropane, xenon and nitrous oxide in the dog. Anesthesiology. 1965 Nov-Dec; 26(6):771-7.
Mitchell RA, Carman CT, Severinghaus JW, Richardson BW, Singer MM, Shnider S. Stability of cerebrospinal fluid pH in chronic acid-base disturbances in blood. J Appl Physiol. 1965 May; 20(3):443-52.
Severinghaus JW. Role of cerebrospinal fluid pH in normalization of cerebral blood flow in chronic hypocapnia. Acta Neurol Scand Suppl. 1965; 14:116-20.
Astrup P, Engel K, Severinghaus JW, Munson E. The influence of temperature and pH on the dissociation curve of oxyhemoglobin of human blood. Scand J Clin Lab Invest. 1965; 17(6):515-23.
SEVERINGHAUS JW. BRONCHIAL MUSCLE CONTROL. Acta Anaesthesiol Scand Suppl. 1964; 15:SUPPL 15:48-51.
LARSON CP, EGER EI, SEVERINGHAUS JW. Ostwald solubility coefficients for anesthetic gases in various fluids and tissues. Anesthesiology. 1962 Sep-Oct; 23:686-9.
EGER EI, JOHNSON EA, LARSON CP, SEVERINGHAUS JW. The uptake and distribution of intravenous ether. Anesthesiology. 1962 Sep-Oct; 23:647-50.
LARSON CP, EGER EI, SEVERINGHAUS JW. The solubility of halothane in blood and tissue homogenates. Anesthesiology. 1962 May-Jun; 23:349-55.
EGER EI, LARSON CP, SEVERINGHAUS JW. The solubility of halothane in rubber, soda lime and various plastics. Anesthesiology. 1962 May-Jun; 23:356-9.
SEVERINGHAUS JW. Electrodes for blood and gas PCO2, and blood pH. Acta Anaesthesiol Scand Suppl. 1962; 11:207-20.
SEVERINGHAUS JW, LARSON CP, EGER EI. Correction factors for infrared carbon dioxide pressure broadening by nitrogen, nitrous oxide and cyclopropane. Anesthesiology. 1961 May-Jun; 22:429-32.
EGER EI, SEVERINGHAUS JW. The rate of rise of PaCO2 in the apneic anesthetized patient. Anesthesiology. 1961 May-Jun; 22:419-25.
MCALEAVY JC, WAY WL, ALTSTATT AH, GUADAGNI NP, SEVERINGHAUS JW. The effect of pCO2 on the depth of anesthesia. Anesthesiology. 1961 Mar-Apr; 22:260-4.
SEVERINGHAUS JW. Methods of measurement of blood and gas carbon dioxide during anesthesia. Anesthesiology. 1960 Nov-Dec; 21:717-26.
SEVERINGHAUS JW, BRADLEY AF. Electrodes for blood pO2 and pCO2 determination. J Appl Physiol. 1958 Nov; 13(3):515-20.
SEVERINGHAUS JW, CULLEN SC. Depression of myocardium and body oxygen consumption with Fluothane. Anesthesiology. 1958 Mar-Apr; 19(2):165-77.
SEVERINGHAUS J. Aneroid manometer for arterial blood pressure. Anesthesiology. 1957 Nov-Dec; 18(6):906-7.
HEBERT CL, RADIGAN LR, SEVERINGHAUS JW. Management of patients during hypothermia. Anesth Analg. 1957 Jan-Feb; 36(1):24-31.
SEVERINGHAUS JW. The telecor: an esophageal probe monitoring device. Anesthesiology. 1957 Jan-Feb; 18(1):145-9.
BRADLEY AF, SEVERINGHAUS JW, STUPFEL M. Variations of serum carbonic acid pK with pH and temperature. J Appl Physiol. 1956 Sep; 9(2):197-200.
BARTELS J, SEVERINGHAUS JW, FORSTER RE, BRISCOE WA, BATES DV. The respiratory dead space measured by single breath analysis of oxygen, carbon dioxide, nitrogen or helium. J Clin Invest. 1954 Jan; 33(1):41-8.
SEVERINGHAUS JW. Electrophrenic respirator; description of a portable all-electronic apparatus. Anesthesiology. 1951 Jan; 12(1):123-8.