Research Category | Project Title | Team Members | Project Description | Project Stage | Research Keywords |
---|---|---|---|---|---|
Basic Science | Gut-Lung axis in traumatic and infectious lung injury | PIs: Arun Prakash Mentors: Judith Hellman, Michael Matthay Collaborators: many |
Please see prakashlab.ucsf.edu | Conception/Idea | Critical Care Physiology Animal Cell |
Basic Science | Effects of sex hormones on susceptibility to early life anesthesia associated deficit. | PIs: Jeffrey Sall Mentors: Roland Bainton Collaborators: Helge Eilers, Mark Schumacher |
Animal based project studying the effects of different drugs and hormones on susceptibility to cognitive deficits after exposure in 7 day old rats. Project involves behavior and wet lab work. | In progress/Data collection | Pediatric Neuro Animal |
Basic Science | Biological Mechanisms for Congenital Heart Disease | PIs: Irfan Kathiriya Mentors: Benoit Bruneau Collaborators: Several in bioinformatics or cardiovascular biology |
We use human cellular models (mutant iPS cells), mouse genetics and genomics, to understand how abnormal gene regulation leads to congenital heart disease. | In progress/Data collection | Pediatric Cardiac Animal Cell Developmental biology Stem cell biology |
Basic Science | Role of Activating Transcription Factor 3 (ATF3) in CNS trauma | PIs: Jonathan Pan Mentors: Zhonghui Guan Collaborators: Hua Su |
The primary objective of the current research proposal is to understand the role of ATF3 in regulation of genes associated with tissue repair and regeneration following spinal cord injury. | In progress/Data collection | Neuro |
Basic Science | Uncovering the pathogenesis and developing new therapies for brain arteriovenous malformation. Impact of peripheral injury on post-stroke cognitive function | PIs: Hua Su Mentors: CCR Collaborators: Helen Kim, Judith Hellman, Zhonghui Guan, Jonathan Pan, Mervyn Maze |
Using the brain AVM mouse models developed in my lab, we will continue elucidate potential pathogenesis of brain AVMs and test new therapies. We will study how fracture influence stroke recovery. |
In progress/Data collection | Neuro Animal |
Basic Science | Mechanism of microglia proliferation | PIs: Zhonghui Guan Mentors: Zhonghui Guan Collaborators: Paul Su |
Microglia proliferation is a hallmark of most neurological diseases, and it plays an important role in the development of these diseases. However, its mechanism is largely unknown. | In progress/Data collection | Pain Neuro |
Basic Science | Sex differences in anesthetic effect on brain development | PIs: Jeffrey Sall Mentors: Jeffrey Sall Collaborators: Gregory Chinn |
Ongoing studies examine the sex difference in vulnerability to anesthesia exposure during brain development. | In progress/Data collection | Pediatric OB Neuro Animal |
Basic Science | Inhibiting Microglial Activation to Prevent Hospital-acquired Cognitive Decline | PIs: Mervyn Maze Mentors: NMN Collaborators: Jonathan Pan |
We have identified neuroinflammation as pivotal for the development of cognitive decline associated with aseptic trauma (as occurs with elective surgery) and severe illness. A key step in neuroinflamm. | Manuscript preparation | Critical Care Neuro Pharmacology |
Clinical
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Near Infrared Spectroscopy in Patients with Depression |
PIs: Art Wallace, M.D., PH.D. |
Develop a Near Infrared Spectroscopy testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression. |
In progress/Data collection |
Neuro |
Clinical |
AVD-M: Non Contact, Remote, Patient Monitor of Heart Rate, Respiratory Rate, Oxygen Saturation, etc. |
PIs: Art Wallace, MD, PhD Mentors: Art Wallace, MD, PhD |
We are developing a non-contact, remote patient monitor of heart rate, respiratory rate, pulse oximetry and a number of other parameters to reduce the risk of cardiac and respiratory arrest. |
In progress/Data collection |
Critical Care |
Clinical |
EEG signatures of Spinal Cord Stimulation related Pain Relief |
PIs: Prasad Shirvalkar |
We are using EEG to identify personalized neural signatures that can predict high vs low pain-states to optimize SCS therapy. Can assist with data analysis. |
In progress/Data collection |
Pain |
Clinical |
Deep Brain Stimulation for Refractory Chronic Pain |
PIs: Edward Chang, Prasad Shirvalkar |
We are developing new brain targets and stimulation protocols for personalized deep brain stimulation to treat refractory chronic pain syndromes. |
In progress/Data collection |
Pain |
Clinical |
Impact of coronary revascularization on longitudinal cognitive change in the elderly |
PIs: Liz Whitlock |
Compare pre- and post-procedure/operative cognitive trajectory in older adults undergoing PCI versus CABG. |
Complete/Data analysis |
Cardiac |
Clinical |
Impact of elective total joint arthoplasty on longitudinal cognitive change in older adults |
PIs: Liz Whitlock |
Modeling cognitive change before and after joint replacement. on the hypothesis that pain/functional deficits before TJA accelerate cognitive decline, and successful TJA rescues. |
Design/Planning |
Pain |
Clinical |
Mild Hypothermia and Acute Kidney Injury (AKI) in Liver Transplantation (MHALT) Trial |
PIs: Michael Bokoch |
MHALT is a randomized controlled multi-center trial of mild hypothermia (34-35 deg C) vs normothermia during liver transplant to find the optimum temperature to preserve post-op kidney function. |
In progress/Data collection |
Critical Care |
Clinical |
Cognitive resilience: predicting a robust cognitive recovery after major surgery |
PIs: Jackie Leung |
Identifying factors that predict robust cognitive status following surgery, hoping to identify modifiable risk factors and develop interventions to improve outcomes. |
Manuscript preparation |
Post-operative delirium |
Clinical |
Opal: Seamless EHR Data Extraction Pipeline for Visualization and Machine Learning in Clinical Anesthesia |
PIs: Andrew Bishara |
Opal’s platform provides clinical users with a dynamic dashboard and allows for targeted cohort selection, model training, and visualization of results of the cohort retrieval and interactive feedback |
Manuscript preparation |
Critical Care |
Clinical | Development of a Machine Learning Algorithm for the Automated Prediction of Postoperative Delirium |
PIs: Anne Donovan |
Using machine learning technology, we will investigate risk factors for postoperative delirium contained in both static preoperative data and dynamic intraoperative data. Funded by NIDUS pilot grant. | In progress/Data collection | Machine Learning |
Clinical | Correlation between mean arterial blood pressure and neurological outcome in human spinal cord injury |
PIs: Jonathan Pan |
A prospective study based on the result from a previous retrospective study showed precise therapeutic window of blood pressure is associated with recovery in acute human SCI by machine intelligence. | In progress/Data collection | Neuro Spine Physiology Machine Learning |
Clinical | Plasticity in Recovery from Surgery: The Effects of Exercise “Prehabilitation”on Cognitive and Functional Recovery after Shoulder Replacement Surgery in Older Adults |
PIs: Ben Ma |
To test the effect of pre-operative exercise on postoperative recovery assessed behaviorally, functionally, and biochemically, we will randomize patients to receive 6 weeks of preoperative exercise. | In progress/Data collection | Cognitive Function |
Clinical | Ultrasound measurement of ulnar and radial artery size in infants and children who undergo general anesthesia |
PIs: Kathryn Rouine-Rapp |
Undertaken to determine baseline difference in size of radial and ulnar arteries in pediatric patients birth up to age 7. Current practice utilizes the radial artery preferentially. |
In progress/Data collection | Pediatric |
Clinical | Use of pupillometry to measure pain and analgesia |
PIs: Matthias Behrends |
This study investigates whether pupillary oscillations which are affected by both pain and analgesic drugs, are useful as a tool to measure pain or better suited to assess central analgesic effects. | In progress/Data collection | Pain |
Clinical | Perioperative outcome of patients on buprenorphine |
PIs: Matthias Behrends |
Retrospective data analysis to the challenges of pain management in patients on partial mu receptor agonists. | In progress/Data collection | Pain |
Clinical | Sedation and Proficiency in English Association Cohort study |
PIs: Liz Whitlock, Tina Vu |
SPEAC is a retrospective cohort study of the association between limited English proficiency and amount of sedation in mechanically ventilated patients in a tertiary care ICU over a 3-year period. | In progress/Data collection | Critical Care Health equity |
Clinical | Markers of Brain vs tissue trauma |
PIs: Jeffrey Sall, Roland Bainton |
We are searching for markers of brain tissue damage that can be separated from markers of soft tissue/bone damage. The project will collect blood samples before and after AVM resection. | Design/Planning | Neuro |
Clinical | T-89, A medication to reduce/prevent altitude illness during rapid ascent. |
PIs: Jeffrey Sall, Andrew Schober |
Trial to determine efficacy of a medication. We also have multiple add on projects looking at physiological changes during rapid ascent to high altitude. |
Complete/Data analysis | Physiology |
Clinical | Direct measurement of brain electrical activity during awakening from anesthesia. Correlates of consciousness. |
PIs: Jeffrey Sall |
We are interested in determining how brain function returns during arousal from anesthesia. We will measure electrical activity directly from electrodes in the brain as patients awaken post sedation. | Design/Planning | Neuro Physiology |
Clinical | Outcomes research in older surgical patients |
PIs: Jacqueline Leung |
Our research deals with perioperative outcomes of the older surgical patients. We have over 2000 patients with robust demographics and outcomes data from RCT & cohort studies. We will mentor faculty | Complete/Data analysis |
Aging |
Clinical | Pediatric Distraction on Induction of Anesthesia with Virtual Reality (PEDI-VR trial) |
PIs: Jina Sinskey, Mike Jung |
Randomized controlled trial looking at the use of virtual reality goggles for induction of general anesthesia in pediatric patients. ClinicalTrials.gov Identifier: NCT03583450. | Manuscript preparation | Virtual Reality |
Clinical | Augmented Reality in Pediatric Patients |
PIs: Jina Sinskey, Justin Libaw |
We plan to study the use of augmented reality goggles for perioperative anxiety in pediatric patients. | Conception/Idea | Virtual Reality |
Clinical | Use of Remifentanil for Open In Utero Fetal Myelomeningocele Repair Maintains Uterine Relaxation with Reduced Volatile Anesthetic Concentration |
PIs: Marla Ferschl, Jina Sinskey |
Retrospective study of high-dose inhaled anesthetic vs. lower-dose inhaled anesthetic with supplemental remifentanil infusion in patients undergoing open fetal myelomeningocele repair. | Manuscript preparation | Pediatric OB |
Clinical | AVD-M (Audiovisual Detection Monitor) |
PIs: Art Wallace |
We are developing a non-contact, remote, patient monitor using machine vision. At present we can measure HR, RR, SaO2 with no sensors on the patient. We expect to detect septic shock, vomiting, stroke. | In progress/Data collection | Critical Care Pain Cardiac Physiology Machine Learning |
Clinical | NIRSIT Near Infrared Spectrophotometry Detection and Measurement of the Severity of Depression |
PIs: Art Wallace, MD, PHD |
We are using near infrared spectrophotometry (NIRS) with 200 lasers to measure frontal lobe blood flow 30 times a second. We can see variations in frontal lobe blood flow with disease state. | In progress/Data collection | Neuro Physiology |
Clinical | Sensifree |
PIs: Art Wallace, MD, Ph.D. |
We are testing a non-invasive device to continuously measure arterial blood pressure based on pulse oximetry signals. The study is collecting intraoperative clinical data in patients with arterialline. | In progress/Data collection | Cardiac Physiology Machine Learning |
Clinical | VA Anesthesia Quality Improvement Project |
PIs: Art Wallace, M.D., PhD |
We are doing VA wide, big data epidemiology to provide reports on surrogate markers of care that are associated with morbidity and mortality. We validate those processes of care and provide QI data VA. | Critical Care Regional Cardiac Neuro Physiology Pharmacology Database Machine Learning Airway |
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Clinical | Qantifying the capnography gap |
PIs: Elliot Wollner, Michael Lipnick |
Global Survey of national society presidents and local providers in low and middle income countries to quantify the capnography and pulse oximetry gaps worldwide. | Design/Planning | Global health |
Clinical | Perioperative Anesthesia Neurocognitive Disorder Assessment- Geriatric PANDA-G study |
PIs: Odmara Barreto Chang |
Our goal is to determine predictors of perioperative neurocognitive disorders (PND) in patients undergoing surgery based on preoperative, intraoperative, and postoperative biomarkers. | In progress/Data collection |
Aging |
Educational | Efficacy and Cost Analysis of Role Play vs. High-Fidelity Simulation for Conflict Management Education | PIs: Jina Sinskey, Kristina Sullivan Mentors: None Collaborators: Joyce Chang, Christy Boscardin, Kevin Thornton |
We plan to study a conflict management curriculum for anesthesia residents using role play and high-fidelity simulation. We will look at the educational benefits and costs of both . modalities. | Design/Planning | Simulation |
Educational | Anesthesia Toolbox: Utilize Google Analytics to assess utilization of educational content on Anesthesia Toolbox. | PIs: Andrew Infosino Mentors: Andrew Infosino Collaborators: Ben Marsh |
Anesthesia Toolbox is an online learning platform for anesthesia resident, fellows and faculty. Project is to analyze page views of educational content to determine utility. | In progress/Data collection | Pediatric Database |
Health Services Research | Household impact of postoperative opioid prescribing | PIs: Catherine Chen Mentors: Adams Dudley, Rosa Rodriguez-Monguio Collaborators: Erica Langnas |
Our study aims to understand whether new opioid use occurs in family members after an individual from a previously opioid-naive household undergoes surgery. | In progress/Data collection | Database |
Health Services Research | Understanding monitored anesthesia care for cataract surgery | PIs: Catherine Chen Mentors: Adams Dudley, Stephen McLeod Collaborators: Rosa Rodriguez-Monguio, Jackie Leung |
Exploring the impact and cost-effectiveness of MAC use on cataract surgery outcomes. | Design/Planning | Database |
Health Services Research | Health Equity in the Perioperative Period |
Pi: Solmaz Manuel |
Significant disparities accross populations exist in the perioperative care for individuals seeking surgical treatment. We are investigating how health literacy, healthcare interactions, socioeconomic factors, cultural beliefs, stereotypes, and implicit bias contribute to these disparities in perioperative health care. | In progress/Data Collection | |
Public health | Impact of gentrification on HbA1c and diabetic amputations in San Francisco | PIs: Tyler Law Mentors: Catherine Chen, Michael Lipnick Collaborators: Laurence Henson |
Examination of HbA1c and diabetic amputation rate over time according to SF neighborhoods that have experienced gentrification. | Design/Planning | Database |
Quality Improvement |
Patient tracking database to monitor outcomes of Pain Neuromodulation Therapies | PIs: Lawrence Poree, Prasad Shirvalkar, Chris Abrecht Mentors: Lawrence Poree, Prasad Shirvalkar, Chris Abrecht Collaborators: Ada Edwards, David Steinhardt |
We are developing a cloud based database to collect information on patient outcomes related to interventions and neuromodulation therapies in the pain clinic. | Design/Planning | Pain Spine Database |
Quality Improvement | Perioperative Pathway | PIs: Lee-lynn Chen Mentors: Multiple Collaborators: Multiple |
We have several perioperative pathways based on surgical service lines that have been well developed with rich data reports. | In progress/Data collection | Critical Care Regional Pain Spine Pharmacology Database Population Health |
Quality Improvement | Design and Implementation of a Perioperative Delirium Prevention and Treatment Pathway | PIs: Anne Donovan Mentors: Liz Whitlock Collaborators: Matthias Braehler, Dave Robinowitz, Emily Finlayson, Stephanie Rogers, Vanja Douglas |
We have designed and implemented multi-faceted perioperative delirium reduction interventions for elderly patients. | Manuscript preparation |
Perioperative medicine |
Quality Improvement | Airway Checklist Prior to Intubation of Trauma Patients in the ED | PIs: Justin Teng, Joseph Brown (ED) Mentors: Benn Lancman Collaborators: Emergency Medicine, Trauma |
Implementation of an airway checklist prior to induction and intubation of a trauma pt who presents to the ED. The goal is to improve safety peri-intubation. | Design/Planning | Airway Trauma |