Professor Emeritus Adrian Gelb, MB ChB, is the senior author of a study published in the July 2019 issue (Vol 131) of Anesthesiology, “Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.” The study was performed with colleagues in China, and showed that in patients with eloquent area gliomas, motor coordination deficits induced by midazolam could be reversed by flumazenil, suggesting a γ-aminobutyric acid–mediated mechanism. The study is relevant to anesthesia practice, especially with awake craniotomies, but also in the PACU and ICU where midazolam may be used in patients with brain tumors. Click here to listen to the Anesthesiology podcast.
