Overview In this project, we hope to demonstrate that sFLT1 (extracellular domain of VEGFR-1) improves bAVM vessel-integrity by inhibiting VEGF signaling and improving adhesion of pericytes to endothelial cells. We will also test whether targeted sFLT1 expression reduces bAVM severity with minimal side effects using AAV vectors that infect neurons or endothelial cells specifically in combination with neuron specific or brain endothelial specific promoter, and whether reduction of microglia/macrophage infiltration enhances sFLT1 therapeutic effect. The overarching goal of this project is to develop a safe and effective method to prevent bAVM hemorrhage. Affiliated Lab Center for Cerebrovascular Research Principal investigator UCSF Hua Su, MD Professor in Residence Collaborators UCSF Helen Kim, MPH, PhD Professor in Residence External persons Steven Hetts, MD Professor, Radiology Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
Center for Cerebrovascular Research Cellular loci involved in the pathogenesis of brain arteriovenous malformations
Center for Cerebrovascular Research Integrated longitudinal studies to identify biomarkers and therapeutic strategies for Sturge-Weber Syndrome (BVMC 6211)
Center for Cerebrovascular Research Investigating disparities and barriers in access to research and care for patients with Hereditary Hemorrhagic Telangiectasia (HHT)
Center for Cerebrovascular Research Detection of somatic mutations in cerebral cavernous malformation patients using non-invasive cell-free DNA screening
Center for Cerebrovascular Research Predictors of growth, recurrence, and high-risk features in pediatric brain arteriovenous malformation (project 1)
Center for Cerebrovascular Research Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Center for Cerebrovascular Research Epigenetic signatures and association with hemorrhage and high risk features in brain arteriovenous malformation
Center for Cerebrovascular Research Cerebral hemorrhage risk in hereditary hemorrhagic telangiectasia (BVMC 6203)
Center for Cerebrovascular Research IL-6 trans-signaling increases risk for perioperative neurocognitive disorders in aging and neurodegenerative diseases
Center for Cerebrovascular Research Modifiers of disease severity and progression in familial cerebral cavernous malformation (BVMC 6201)