Overview In this project, we hope to demonstrate that sFLT1 (extracellular domain of VEGFR-1) improves bAVM vessel-integrity by inhibiting VEGF signaling and improving adhesion of pericytes to endothelial cells. We will also test whether targeted sFLT1 expression reduces bAVM severity with minimal side effects using AAV vectors that infect neurons or endothelial cells specifically in combination with neuron specific or brain endothelial specific promoter, and whether reduction of microglia/macrophage infiltration enhances sFLT1 therapeutic effect. The overarching goal of this project is to develop a safe and effective method to prevent bAVM hemorrhage. Affiliated Lab Center for Cerebrovascular Research Principal investigator UCSF Hua Su, MD Professor in Residence Collaborators UCSF Helen Kim, MPH, PhD Professor in Residence External persons Steven Hetts, MD Professor, Radiology Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
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