Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)

Individuals with cerebral cavernous malformations, also known as cavernous angiomas (CA) have clusters of abnormally enlarged blood vessels in the brain and spinal cord. These abnormal clusters may be sporadic or familial (inherited) and can cause problems, such as hemorrhagic strokes, recurrent seizures, neurological deficits, or disabling headaches. Cavernous angiomas with recent symptomatic hemorrhage (CASH) are most likely to re-bleed again causing clinical problems. Yet, diagnostic and prognostic biomarkers of hemorrhage are lacking.  

The major goal of this project is to develop blood tests, potentially reflecting or complementing novel imaging assessments, to better diagnose and predict CASH in adults. The project tests a novel integrational approach in a mechanistically defined cerebrovascular disease, with potential applications to other brain pathologies, and is done in collaboration with researchers at the University of Chicago and the Mayo Clinic in Rochester, MN. 

For more information about the study
Patient Advocacy Group for CCM   
To request a clinic appointment at the UCSF CCM Center of Excellence