Overview Individuals with cerebral cavernous malformations, also known as cavernous angiomas (CA) have clusters of abnormally enlarged blood vessels in the brain and spinal cord. These abnormal clusters may be sporadic or familial (inherited) and can cause problems, such as hemorrhagic strokes, recurrent seizures, neurological deficits, or disabling headaches. Cavernous angiomas with recent symptomatic hemorrhage (CASH) are most likely to re-bleed again causing clinical problems. Yet, diagnostic and prognostic biomarkers of hemorrhage are lacking. The major goal of this project is to develop blood tests, potentially reflecting or complementing novel imaging assessments, to better diagnose and predict CASH in adults. The project tests a novel integrational approach in a mechanistically defined cerebrovascular disease, with potential applications to other brain pathologies, and is done in collaboration with researchers at the University of Chicago and the Mayo Clinic in Rochester, MN. For more information about the studyPatient Advocacy Group for CCM To request a clinic appointment at the UCSF CCM Center of Excellence Affiliated Lab Center for Cerebrovascular Research Principal investigator UCSF Helen Kim, MPH, PhD Professor in Residence External persons Issam Awad, MD Professor, Dept of Neurological Surgery, University of Chicago Kelly Flemming, MD Professor, Dept of Neurology, Mayo Clinic – Rochester Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
Center for Cerebrovascular Research Cellular loci involved in the pathogenesis of brain arteriovenous malformations
Center for Cerebrovascular Research Detection of somatic mutations in cerebral cavernous malformation patients using non-invasive cell-free DNA screening
Center for Cerebrovascular Research Epigenetic signatures and association with hemorrhage and high risk features in brain arteriovenous malformation
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Center for Cerebrovascular Research Modifiers of disease severity and progression in familial cerebral cavernous malformation (BVMC 6201)
Center for Cerebrovascular Research Reduction of brain AVM severity through inhibition of pathogenic angiogenesis
Center for Cerebrovascular Research Predictors of growth, recurrence, and high-risk features in pediatric brain arteriovenous malformation (project 1)
Center for Cerebrovascular Research IL-6 trans-signaling increases risk for perioperative neurocognitive disorders in aging and neurodegenerative diseases
Center for Cerebrovascular Research Integrated longitudinal studies to identify biomarkers and therapeutic strategies for Sturge-Weber Syndrome (BVMC 6211)