Overview In this study, we will test our hypothesis that mutant endothelial cells impair mural function through a reduction of PDGFB expression, and activate microglia, astrocytes, and fibroblasts through endothelial inflammation; malfunction of other cells further enhances endothelial inflammation and bAVM severity. We will test (1) if mutant endothelial cells impair mural cell function through reduction of PDGFB expression and imbalance of EPHRINB2/EPHB4 signaling (2) if mutant endothelial cells activate microglia and astrocytes, and fibroblasts through endothelial inflammation. The goal of this study is to identify new targets for developing new therapies for bAVM patients. Affiliated Lab Center for Cerebrovascular Research Principal investigator UCSF Hua Su, MD Professor Collaborators UCSF Judith Hellman, MD Professor External persons Tom Arnold, MD Associate Professor in Residence Pediatrics Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
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