Biography My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery. Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Education 2019 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaPostdoctoral Fellow, 1992 - Medicine, University of California, San Francisco Publications Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in Mouse. Shabani Z, Do Prado LB, Zhang R, Zhu W, Shaligram SS, Yadav A, Wang C, Su H Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy. Yadav A, Liang R, Press K, Schmidt A, Shabani Z, Leng K, Wang C, Sekhar A, Shi J, Devlin GW, Gonzalez TJ, Asokan A, Su H Evaluation of Aav Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy. Yadav A, Liang R, Press K, Schmidt A, Shabani Z, Leng K, Wang C, Sekhar A, Shi J, Devlin GW, Gonzalez TJ, Asokan A, Su H ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation. Ma L, Zhu X, Tang C, Pan P, Yadav A, Liang R, Press K, Nelson J, Su H Abstract 116: Increased Collagen I/Collagen III Ratio is Associated With Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Zahra Shabani nabikandi, Joana Schurger, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Helen Kim, Hua Su Abstract TMP3: Overexpression of Alk1 in Brain Endothelial Cells Alleviates the Severity of Brain Arteriovenous Malformations in Alk1 Mutant Mice. Alka Yadav, Rich Liang, Kelly Press, Annika Schmidt, Zahra Shabani nabikandi, Sally Huang, Trevor Gonzalez, Aravind Asokan, Hua Su Abstract TMP5: Mutation of Pdgfrß Enhances the Severity of Brain Arteriovenous Malformation on Endoglin Mutant Mice Through Exacerbation of Angiogenesis and Inflammation. Alka Yadav, Leandro Barbosa Do Prado, Chaoliang Tang, Sonali Shaligram, Rich Liang, Kelly Press, Jasneet Dhaliwal, Ethan A Winkler, Hua Su Abstract TP2: Increase of EphrinB2/EphB4 Signaling Reduces the Severity of Brain Arteriovenous Malformation in Endoglin Deficient Mice Through Reduction of Angiogenesis and Inflammation. Zahra Shabani nabikandi, Leandro Barbosa Do Prado, Alka Yadav, Rui Zhang, Wan Zhu, Sonali Shaligram, Joana Schuger, Rich Liang, Kelly Press, Hua Su Abstract WP318: Increased Synapse Elimination by Inflammatory Cells Contribute to Lon-Lasting Post-Stroke Memory Dysfunction in Aged Mice. Zahra Shabani nabikandi, peipei Pan, Qifeng Li, Zhanqiang Wang, Kang Huo, Hua Su Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Shabani Z, Schuerger J, Zhu X, Tang C, Ma L, Yadav A, Liang R, Press K, Weinsheimer S, Schmidt A, Wang C, Sekhar A, Nelson J, Kim H, Su H Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19. Shabani Z, Liu J, Su H CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation. Ma L, Zhu X, Tang C, Pan P, Yadav A, Liang R, Press K, Su H Abstract 52: Prevalence Of Somatic Activating Kras Mutations In Pediatric And Adult Sporadic Brain Arteriovenous Malformations. Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim Cellular loci involved in the development of brain arteriovenous malformations. Shabani Z, Schuerger J, Su H Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage. Sato Y, Falcone-Juengert J, Tominaga T, Su H, Liu J Potential Targets for the Treatment of Brain Arteriovenous Malformations. Yadav A, Su H N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J Abstract 19: Long-lasting Post-stroke Memory Dysfunction In Aged Mice Is Like Due To Exacerbated Hippocampal Inflammation And Synapses Removing. Peipei Pan, Qifeng Li, Zhanqiang Wang, Rich Liang, Kang Huo, Eric Ding, Chandler Beon, Kelly Press, Hua Su Abstract TMP5: Bone Marrow-derived And Clonally Expanded Alk1- Endothelial Cells Contribute To Brain Arteriovenous Malformation In Mice. Sonali Shaligram, Rui Zhang, Wan Zhu, Li Ma, Man Luo, Qiang Li, Miriam Weiss, Thomas Arnold, Santander Grez NG, Rich Liang, Leandro Predo, Chaoliang Tang, Peipei Pan, Hua Su 12 Genetics and Vascular Biology of Brain Vascular Malformations. Helen Kim, Ludmila Pawlikowska, Hua Su Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice. Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype. Gao S, Nelson J, Weinsheimer S, Winkler EA, Rutledge C, Abla AA, Gupta N, Shieh JT, Cooke DL, Hetts SW, Tihan T, Hess CP, Ko N, Walcott BP, McCulloch CE, Lawton MT, Su H, Pawlikowska L, Kim H Review of treatment and therapeutic targets in brain arteriovenous malformation. Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation. Muster R, Ko N, Smith W, Su H, Dickey MA, Nelson J, McCulloch CE, Sneed PK, Clarke JL, Saloner DA, Eisenmenger L, Kim H, Cooke DL Abstract 63: Mutation of Platelet-Derived Growth Factor Receptor B Causes Cerebrovascular Malformation and Enhances Brain Arteriovenous Malformation Severity in Mice. Leandro Prado, Chaoliang Tang, Sonali Shaligram, Rich Liang, Ethan Winkler, Hua Su Abstract P795: Activating Transcription Factor 3 Improves Stroke Recovery Through Reduction of Neuronal Damage and Neuroinflammation. Zhanqiang Wang, Peipei Pan, Rich Liang, Qifeng Li, Janothon Pan, Zhonghui Guan, Hua Su Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction. Huo K, Wei M, Zhang M, Wang Z, Pan P, Shaligram SS, Huang J, Prado LBD, Wong J, Su H Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice J Huang, H Lyu, K Huo, LB Do Prado, C Tang,Z Wang, Q Li, J Wong, and H Su Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice. Huang J, Lyu H, Huo K, Do Prado LB, Tang C, Wang Z, Li Q, Wong J, Su H The role of mural cells in hemorrhage of brain arteriovenous malformation. Pan P, Shaligram SS, Do Prado LB, He L, Su H Reduction of endoglin receptor impairs mononuclear cell-migration. Han Z, Shaligram S, Faughnan ME, Clark D, Sun Z, Su H Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report. Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL Abstract TP118: Activation of Alpha-7 Nicotinic Acetylcholine Receptor Improved Long-Term Cognitive Function of Mice With Long-Bone Fracture and Stroke. Kang Hou, Meng Wei, Meng Zhang, Zhanqiang Wang, Sonali Shaligram, Jinhao Huang, Leandro Barbosa Do Prado, Julia Wong, Rose Carion, Tuanpeng Sun, Lei Zhan, Hua SU Abstract TP119: Tibia Fracture Leads to Long-Lasting Memory Dysfunction in Mice Through Enhanced Blood-Brain Barrie Breakdown in the Hippocampus and White Matter Damage. Jinhao Huang, Haiyan Lyu, Kang Hou, Leandro Barbosa Do Prado, Chaoliang Tang, Zhanqiang Wang, Julia Wong, Hua Su Recent Advances in Basic Research for Brain Arteriovenous Malformation. Barbosa Do Prado L, Han C, Oh SP, Su H Risk factors for hemorrhage of brain arteriovenous malformation. Shaligram SS, Winkler E, Cooke D, Su H Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation. Cheng P, Ma L, Shaligram S, Walker EJ, Yang ST, Tang C, Zhu W, Zhan L, Li Q, Zhu X, Lawton MT, Su H Abstract 66: Reduction of the Number of Endothelial Cells Harboring Mutations of AVM Causative Genes Lessens Brain AVM Severity. Sonali S Shaligram, Rui Zhang, Cameron M McDougall, Wan Zhu, Wan Zhu, Li Ma, Michael L Lawton, Hua Su Abstract TMP105: Elevation of VEGF Exacerbates Hemorrhage in Mouse Brain Arteriovenous Malformation. Li Ma, Philip Cheng, Sonali Shaligram, Espen J Walker, Shun-Tai Yang, Chaoliang Tang, Wan Zhu, Qiang Li, Xiaonan Zhu, Hua Su Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction. Li Z, Wei M, Lyu H, Huo K, Wang L, Zhang M, Su H Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice. Zhu W, Saw D, Weiss M, Sun Z, Wei M, Shaligram S, Wang S, Su H Risk factors for ischemic stroke post bone fracture. An Q, Chen Z, Huo K, Su H, Qu QM Impact of Bone Fracture on Ischemic Stroke Recovery. Wei M, Lyu H, Huo K, Su H SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. Zhang M, Deng YN, Zhang JY, Liu J, Li YB, Su H, Qu QM Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model. Zhu W, Chen W, Zou D, Wang L, Bao C, Zhan L, Saw D, Wang S, Winkler E, Li Z, Zhang M, Shen F, Shaligram S, Lawton M, Su H Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation. Wan Zhu, Rui Zhang, Li Ma, Hua Su Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL Inflammation and genetic factors in stroke pathogenesis. Su H The roles of endoglin gene in cerebrovascular diseases. Zhu W, Ma L, Zhang R, Su H Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z 381 Reductions in Brain Pericytes are Associated with Arteriovenous Malformation Vascular Instability. Ethan A Winkler, Harjus Birk, Jan-Karl Burkhardt, Xiaolin Chen, John K Yue, Diana Guo, William Caleb Rutledge, George Lasker, Tarik Tihan, Edward F Chang, Hua Su, Helen Kim, Brian Patrick Walcott, Michael T Lawton Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation. Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y Abstract 125: Increased Endothelial Endoglin Gene Deletion and Co-deletion of EphrinB2 Enhance Brain Arteriovenous Malformation in Mice. Rui Zhang, Wan Zhu, Li Ma, Man Luo, Lei Zhan, Hua Su Abstract 198: Endovascular Biopsy: in vivo Brain Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Daniel L Cooke, Van Halbach, Steven Hetts, Matthew Amans, Christopher Dowd, Randall Higashida, Devon Lawson, Jeffrey Nelson, David McCoy, Helen Kim, Tomoki Hashimoto, Zena Werb, Hua Su, Zhengda Sun Abstract TMP111: Thalidomide and Lenalidomide Treatment Reduces Microhemorrhage in Brain Arteriovenous Malformation in Mice Through Increasing Mural Cell Coverage. Wan Zhu, Dingquan Zou, Wanqiu Chen, Chen Bao, Rui Zhang, Lei Zhan, Zhengxi Li, Meng Zhang, Ethan Winkler, Michael T. Lawton, Hua Su Abstract TP445: Bevacizumab Therapy for Brain Arteriovenous Malformations. Daniel L Cooke, Helen Kim, Wade Smith, Michael Lawton, Jennifer Clarke, David Saloner, Nerissa Ko, Patricia Sneed, Charles McCulloch, Hua Su Gene Therapy for Stroke. Fanxia Shen, Hua Su Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H Correction: Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. Liu J, Su H, Qu QM Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages. Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model. Zhang JY, Deng YN, Zhang M, Su H, Qu QM Recombinant VLP-Z of JC Polyomavirus: A Novel Vector for Targeting Gene Delivery. Deng YN, Zeng JY, Su H, Qu QM Impact and risk factors of post-stroke bone fracture. Huo K, Hashim SI, Yong KL, Su H, Qu QM Abstract 54: Soluble FLT1 Gene Therapy Through Systemic Viral Delivery Reduces the Severity of Mouse Brain Arteriovenous Malformation. Wan Zhu, Fanxia Shen, Shuai Kang, Lei Mao, Zhengda Sun, Dingquan Zou, Rui Zhang, Lei Zhan, John Forsayeth, Hua Su Abstract WP111: Activation of a7 Nicotinic Acetylcholine Receptor Improves Blood-Brain Barrier Integrity in Mice with Ischemic Stroke and Bone Fracture. Dingquan Zou, Zhenyi Han, Lei Zhan, Wan Zhu, Shuai Kang, Chen Bao, Alireza Sadighi, Zhao Li, Jeffrey Nelson, Rui Zhang, Hua Su 12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations. Helen Kim, Ludmila Pawlikowska, Hua Su, William L. Young Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Zhang R, Zhu W, Su H Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels✩. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL Review Ma L, Guo Y, Zhao YL, Su H Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H 385. Intravenous Delivery of AAV9-CMV-sFLT1 Reduces the Severity of Brain Arteriovenous Malformation Without Causing Significant Side Effects in a Mouse Model. Wan Zhu, Fanxia Shen, Lei Zhan, Shuai Kang, Rui Zhang, Dingquan Zou, John Forsayeth, Zhijian Wu, Peter Colosi, Hua Su Abstract 191: Persistent Infiltration of Active Microglia in Brain Arteriovenous Malformation Causes Unresolved Inflammation and Lesion Progression. Rui Zhang, Vincent Degos, Shuai Kang, Michael Wong, Lei Zhan, Hua Su Abstract W P413: Intravenous Delivery of the AAV9-sFLT Vector Reverses the Phenotype of Spontaneously Developed Brain Arteriovenous Malformation in Mice. Lei Mao, Fanxia Shen, Yue He, Lei Zhan, Michael T. Lawton, Hua Su Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Daniel L Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W Hetts, Randall T Higashida, Christopher F Dowd, Van V Halbach, Hua Su, Maythem M Saeed Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT Endovascular Biopsy: Technical Feasibility of Novel Endothelial Cell Harvesting Devices Assessed in a Rabbit Aneurysm Model. Daniel L. Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W. Hetts, Randall T. Higashida, Christopher F. Dowd, Van V. Halbach, Hua Su, Maythem M. Saeed Endovascular treatment of severe acute basilar artery occlusion Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z Targeted Gene Therapy for Ischemic Stroke. Fanxia Shen, Hua Su The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation. Ma L, Guo Y, Zhao YL, Su H Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H. Endovascular treatment of severe acute basilar artery occlusion. Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. Han Z, Li L, Wang L, Degos V, Maze M, Su H Endoglin deficiency impairs stroke recovery. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Chen W, Choi EJ, McDougall CM, Su H Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H Abstract W P98: Activation of a7 Nicotinic Acetylcholine Receptor Reduces Pro-Inflammatory Macrophage and Improves Ischemic Stroke Recovery. Zhenying Han, Fanxia Shen, Yue He, Vincent Degos, Marine Camus, Mamta Wankhede, Mervyn Maze, William L. Young, Hua Su De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H Development of the central nervous system vasculature and the pathogenesis of brain arteriovenous malformations. Steven W. Hetts, Hua Su, Tarik Tihan, Tomoki Hashimoto, Ludmila Pawlikowska, Michael T. Lawton Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H ERRATUM TO: Induction of Brain Arteriovenous Malformation in the Adult Mouse. Wanqiu Chen, William L. Young, Hua Su Induction of brain arteriovenous malformation in the adult mouse. Chen W, Young WL, Su H Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV Bone fracture exacerbates murine ischemic cerebral injury. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M Abstract TMP116: AAV-sFLT: A Potential Therapeutic Agent for the Treatment of Brain Angiogenic Diseases. Lei Mao, Fanxia Shen, Wanqiu Chen, Babatunde Akinpelu, Michael T. Lawton, William L. Young, Hua Su Abstract TMP118: Alk1 Deficiency Impairs Mural Cell Recruitment During Brain Angiogenesis. Wanqiu Chen, Yi Guo, Kristine Jun, Mamta Wankhede, Hua Su, William L. Young Abstract TMP69: Endoglin Deficiency Exacerbates Ischemic Brain Injury. Fanxia Shen, Vincent Degos, Zhenying Han, Eun-Jung Choi, William L. Young, Hua Su Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation. Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Pile-Spellman J, Su H, Young WL Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Shen F, Kuo R, Milon-Camus M, Han Z, Jiang L, Young WL, Su H Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim, Yongmei Chen, Charles E. McCulloch, Nicholas M. Barbaro, Michael T. Lawton, William L. Young, Gregory J. Bix Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Walker EJ, Su H, Shen F, Degos V, Amend G, Jun K, Young WL Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL, University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project Abstract 2217: Magnetic Resonance Blood-Brain Barrier Permeability Measurements To Predict Hemorrhagic Transformation In A Rat Model Of Ischemic Stroke. Angelika Hoffmann, Jo¨rg Bredno, Michael F Wendland, Nikita Derugin, Jason Hom, Hua Su, Peter T Ohara, William L Young, Max Wintermark Abstract 3153: Endoglin Deficiency in Bone Marrow is Sufficient to Cause Vascular Dysplasia in the Adult Mouse Brain After VEGF Stimulation. Eun-Jung Choi, Espen J. Walker, Kristine Jun, Robert Kuo, Hua Su, William L. Young Abstract 3169: Reduced PDGFR-beta Expression After Regional Alk1 Deletion and VEGF Stimulation in the Brain is Associated with Reduced Mural Cell Coverage. Wanqiu Chen, Yi Guo, Andrew W. Bollen, Hua Su, William L. Young Abstract 3187: Inflammatory Cell Infiltration Correlates with Hemosiderin Deposition (Intra-lesion Hemorrhage) in Surgical Excised Unruptured Human Brain Arteriovenous Malformations. Yi Guo, Hua Su, Helen Kim, Michael T. Lawton, Andrew W. Bollen, William L. Young Abstract 3190: Increased Inflammatory Response in Aged Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke. Fanxia Shen, Lidan Jiang, Robert Kuo, Vincent Degos, Espen J. Walker, Hua Su, William L. Young Abstract 3194: Bevacizumab (Avastin) Crosses the Blood-brain Barrier and Attenuates VEGF-induced Angiogenesis and Vascular Dysplasia in an Adult Mouse Model of Brain Arteriovenous Malformations. Espen J. Walker, Hua Su, Fanxia Shen, Kristine Jun, Vincent Degos, Gregory Amend, William L. Young Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis. Walker EJ, Shen F, Young WL, Su H Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis. Walker EJ, Shen F, Young WL, Su H Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H Arteriovenous malformation in the adult mouse brain resembling the human disease. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL Treatment of focal brain ischemia with viral vector-mediated gene transfer. Su H, Yang GY Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Gao P, Shen F, Gabriel RA, Law D, Yang EY, Yang E, Yang GY, Young WL, Su H Combining angiogenic gene and stem cell therapies for myocardial infarction. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H Soluble endoglin modulates aberrant cerebral vascular remodeling. Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY VEGF improves survival of mesenchymal stem cells in infarcted hearts. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB Overexpression of netrin-1 induces neovascularization in the adult mouse brain. Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW Development of a cerebral microvascular dysplasia model in rodents. Su H, Hao Q, Shen F, Zhu Y, Lee CZ, Young WL, Yang GY Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping. Beiter T, Zimmermann M, Fragasso A, Armeanu S, Lauer UM, Bitzer M, Su H, Young WL, Niess AM, Simon P Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY Adeno-Associated Viral Vector-Delivered Hypoxia-Inducible Gene Expression in Ischemic Hearts. Hua Su, Yuet Wai Kan Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Su H, Kan YW Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW 228. AAV Mediated Hypoxia-Inducible VEGF Expression and Neovascular Formation in Ischemic Pig Myocardium. Hua Su, Yerem Yeghiazarians, Andrew Lee, Yu Huang, Janice Arakawa-Hoyt, Jianqin Ye, Gina Orcino, William Growssman, Yuet W. Kan 343. Vascular Endothelial Growth Factor Prevents Bone Marrow Derived-Mesenchymal Stem Cell Senescence In Vitro. Jennifer Pons, Hua Su, Yu Huang, Y.W. Kan Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Chang DS, Su H, Tang GL, Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Su H, Arakawa-Hoyt J, Kan YW Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart. Su H, Lu R, Kan YW Adeno-associated viral-mediated gene transfer to hepatoma: thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated than in GCV-treated animals. Su H, Lu R, Ding R, Kan YW Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice. Su H, Lu R, Chang JC, Kan YW Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. Kypta RM, Su H, Reichardt LF Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Su H, Chang JC, Xu SM, Kan YW Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Su H, Lau YF Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Su H, Lau YF Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U
