Hua Su, MD
Professor In Residence
Biography:
My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery.
Publications:
Ma L, Zhu X, Tang C, Pan P, Yadav A, Liang R, Press K, Nelson J, Su H. CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation. J Cereb Blood Flow Metab. 2024 Feb 28; 271678X241236008.
Zahra Shabani nabikandi, Joana Schurger, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Helen Kim, Hua Su. Abstract 116: Increased Collagen I/Collagen III Ratio is Associated With Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Stroke. 2024 Feb 1; 55(Suppl_1).
Alka Yadav, Rich Liang, Kelly Press, Annika Schmidt, Zahra Shabani nabikandi, Sally Huang, Trevor Gonzalez, Aravind Asokan, Hua Su. Abstract TMP3: Overexpression of Alk1 in Brain Endothelial Cells Alleviates the Severity of Brain Arteriovenous Malformations in Alk1 Mutant Mice. Stroke. 2024 Feb 1; 55(Suppl_1).
Alka Yadav, Leandro Barbosa Do Prado, Chaoliang Tang, Sonali Shaligram, Rich Liang, Kelly Press, Jasneet Dhaliwal, Ethan A Winkler, Hua Su. Abstract TMP5: Mutation of Pdgfrß Enhances the Severity of Brain Arteriovenous Malformation on Endoglin Mutant Mice Through Exacerbation of Angiogenesis and Inflammation. Stroke. 2024 Feb 1; 55(Suppl_1).
Zahra Shabani nabikandi, Leandro Barbosa Do Prado, Alka Yadav, Rui Zhang, Wan Zhu, Sonali Shaligram, Joana Schuger, Rich Liang, Kelly Press, Hua Su. Abstract TP2: Increase of EphrinB2/EphB4 Signaling Reduces the Severity of Brain Arteriovenous Malformation in Endoglin Deficient Mice Through Reduction of Angiogenesis and Inflammation. Stroke. 2024 Feb 1; 55(Suppl_1).
Zahra Shabani nabikandi, peipei Pan, Qifeng Li, Zhanqiang Wang, Kang Huo, Hua Su. Abstract WP318: Increased Synapse Elimination by Inflammatory Cells Contribute to Lon-Lasting Post-Stroke Memory Dysfunction in Aged Mice. Stroke. 2024 Feb 1; 55(Suppl_1).
Shabani Z, Schuerger J, Zhu X, Tang C, Ma L, Yadav A, Liang R, Press K, Weinsheimer S, Schmidt A, Wang C, Sekhar A, Nelson J, Kim H, Su H. Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Cells. 2024 01 01; 13(1).
Shabani Z, Liu J, Su H. Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19. Biology (Basel). 2023 Aug 09; 12(8).
Ma L, Zhu X, Tang C, Pan P, Yadav A, Liang R, Press K, Su H. CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation. Res Sq. 2023 May 12.
Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim. Abstract 52: Prevalence Of Somatic Activating Kras Mutations In Pediatric And Adult Sporadic Brain Arteriovenous Malformations. Stroke. 2023 Feb 1; 54(Suppl_1):a52-a52.
Shabani Z, Schuerger J, Su H. Cellular loci involved in the development of brain arteriovenous malformations. Front Hum Neurosci. 2022; 16:968369.
Sato Y, Falcone-Juengert J, Tominaga T, Su H, Liu J. Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage. Cells. 2022 09 09; 11(18).
Yadav A, Su H. Potential Targets for the Treatment of Brain Arteriovenous Malformations. Transl Stroke Res. 2023 10; 14(5):628-630.
Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J. N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. J Neuroinflammation. 2022 May 24; 19(1):118.
Peipei Pan, Qifeng Li, Zhanqiang Wang, Rich Liang, Kang Huo, Eric Ding, Chandler Beon, Kelly Press, Hua Su. Abstract 19: Long-lasting Post-stroke Memory Dysfunction In Aged Mice Is Like Due To Exacerbated Hippocampal Inflammation And Synapses Removing. Stroke. 2022 Feb 1; 53(Suppl_1):a19-a19.
Sonali Shaligram, Rui Zhang, Wan Zhu, Li Ma, Man Luo, Qiang Li, Miriam Weiss, Thomas Arnold, Santander Grez NG, Rich Liang, Leandro Predo, Chaoliang Tang, Peipei Pan, Hua Su. Abstract TMP5: Bone Marrow-derived And Clonally Expanded Alk1- Endothelial Cells Contribute To Brain Arteriovenous Malformation In Mice. Stroke. 2022 Feb 1; 53(Suppl_1):atmp5-atmp5.
Helen Kim, Ludmila Pawlikowska, Hua Su. 12 Genetics and Vascular Biology of Brain Vascular Malformations. . 2022 Jan 1; (N Engl J Med 340 1999):138-152.e8.
Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H. Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice. Transl Stroke Res. 2022 06; 13(3):494-504.
Gao S, Nelson J, Weinsheimer S, Winkler EA, Rutledge C, Abla AA, Gupta N, Shieh JT, Cooke DL, Hetts SW, Tihan T, Hess CP, Ko N, Walcott BP, McCulloch CE, Lawton MT, Su H, Pawlikowska L, Kim H. Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype. J Neurosurg. 2022 01 01; 136(1):148-155.
Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H. Review of treatment and therapeutic targets in brain arteriovenous malformation. J Cereb Blood Flow Metab. 2021 12; 41(12):3141-3156.
Muster R, Ko N, Smith W, Su H, Dickey MA, Nelson J, McCulloch CE, Sneed PK, Clarke JL, Saloner DA, Eisenmenger L, Kim H, Cooke DL. Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation. BMJ Neurol Open. 2021; 3(1):e000114.
Leandro Prado, Chaoliang Tang, Sonali Shaligram, Rich Liang, Ethan Winkler, Hua Su. Abstract 63: Mutation of Platelet-Derived Growth Factor Receptor B Causes Cerebrovascular Malformation and Enhances Brain Arteriovenous Malformation Severity in Mice. Stroke. 2021 Mar 1; 52(Suppl_1).
Zhanqiang Wang, Peipei Pan, Rich Liang, Qifeng Li, Janothon Pan, Zhonghui Guan, Hua Su. Abstract P795: Activating Transcription Factor 3 Improves Stroke Recovery Through Reduction of Neuronal Damage and Neuroinflammation. Stroke. 2021 Mar 1; 52(Suppl_1).
Huo K, Wei M, Zhang M, Wang Z, Pan P, Shaligram SS, Huang J, Prado LBD, Wong J, Su H. Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction. J Cereb Blood Flow Metab. 2021 09; 41(9):2162-2173.
J Huang, H Lyu, K Huo, LB Do Prado, C Tang,Z Wang, Q Li, J Wong, and H Su. Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice. International Journal of Molecular Science. 2020; (21):8481.
Huang J, Lyu H, Huo K, Do Prado LB, Tang C, Wang Z, Li Q, Wong J, Su H. Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice. Int J Mol Sci. 2020 Nov 11; 21(22).
Pan P, Shaligram SS, Do Prado LB, He L, Su H. The role of mural cells in hemorrhage of brain arteriovenous malformation. Brain Hemorrhages. 2021 Mar; 2(1):49-56.
Han Z, Shaligram S, Faughnan ME, Clark D, Sun Z, Su H. Reduction of endoglin receptor impairs mononuclear cell-migration. Explor Med. 2020; 1:136-148.
Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL. Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report. Interdiscip Neurosurg. 2020 Jun; 20.
Kang Hou, Meng Wei, Meng Zhang, Zhanqiang Wang, Sonali Shaligram, Jinhao Huang, Leandro Barbosa Do Prado, Julia Wong, Rose Carion, Tuanpeng Sun, Lei Zhan, Hua SU. Abstract TP118: Activation of Alpha-7 Nicotinic Acetylcholine Receptor Improved Long-Term Cognitive Function of Mice With Long-Bone Fracture and Stroke. Stroke. 2020 Feb 1; 51(Suppl_1).
Jinhao Huang, Haiyan Lyu, Kang Hou, Leandro Barbosa Do Prado, Chaoliang Tang, Zhanqiang Wang, Julia Wong, Hua Su. Abstract TP119: Tibia Fracture Leads to Long-Lasting Memory Dysfunction in Mice Through Enhanced Blood-Brain Barrie Breakdown in the Hippocampus and White Matter Damage. Stroke. 2020 Feb 1; 51(Suppl_1).
Barbosa Do Prado L, Han C, Oh SP, Su H. Recent Advances in Basic Research for Brain Arteriovenous Malformation. Int J Mol Sci. 2019 Oct 25; 20(21).
Shaligram SS, Winkler E, Cooke D, Su H. Risk factors for hemorrhage of brain arteriovenous malformation. CNS Neurosci Ther. 2019 10; 25(10):1085-1095.
Cheng P, Ma L, Shaligram S, Walker EJ, Yang ST, Tang C, Zhu W, Zhan L, Li Q, Zhu X, Lawton MT, Su H. Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation. J Neurosurg. 2019 Apr 26; 132(5):1566-1573.
Sonali S Shaligram, Rui Zhang, Cameron M McDougall, Wan Zhu, Wan Zhu, Li Ma, Michael L Lawton, Hua Su. Abstract 66: Reduction of the Number of Endothelial Cells Harboring Mutations of AVM Causative Genes Lessens Brain AVM Severity. Stroke. 2019 Feb 1; 50(Suppl_1).
Li Ma, Philip Cheng, Sonali Shaligram, Espen J Walker, Shun-Tai Yang, Chaoliang Tang, Wan Zhu, Qiang Li, Xiaonan Zhu, Hua Su. Abstract TMP105: Elevation of VEGF Exacerbates Hemorrhage in Mouse Brain Arteriovenous Malformation. Stroke. 2019 Feb 1; 50(Suppl_1).
Li Z, Wei M, Lyu H, Huo K, Wang L, Zhang M, Su H. Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction. J Cereb Blood Flow Metab. 2020 02; 40(2):446-455.
Zhu W, Saw D, Weiss M, Sun Z, Wei M, Shaligram S, Wang S, Su H. Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice. Transl Stroke Res. 2019 10; 10(5):557-565.
Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 12 01; 129(6):1464-1474.
An Q, Chen Z, Huo K, Su H, Qu QM. Risk factors for ischemic stroke post bone fracture. J Clin Neurosci. 2019 Jan; 59:224-228.
Wei M, Lyu H, Huo K, Su H. Impact of Bone Fracture on Ischemic Stroke Recovery. Int J Mol Sci. 2018 May 22; 19(5).
Zhang M, Deng YN, Zhang JY, Liu J, Li YB, Su H, Qu QM. SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. Aging Dis. 2018 Apr; 9(2):273-286.
Zhu W, Chen W, Zou D, Wang L, Bao C, Zhan L, Saw D, Wang S, Winkler E, Li Z, Zhang M, Shen F, Shaligram S, Lawton M, Su H. Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model. Stroke. 2018 05; 49(5):1232-1240.
Wan Zhu, Rui Zhang, Li Ma, Hua Su. Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation. Molecular, Genetic, and Cellular Advances in Cerebrovascular Diseases. 2018 Feb 1; 83-126.
Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16; 9(13):10945-10961.
Su H. Inflammation and genetic factors in stroke pathogenesis. Neuroimmunol Neuroinflamm. 2017; 4:260-262.
Zhu W, Ma L, Zhang R, Su H. The roles of endoglin gene in cerebrovascular diseases. Neuroimmunol Neuroinflamm. 2017; 4:199-210.
Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2018 02; 9(1):20-33.
Ethan A Winkler, Harjus Birk, Jan-Karl Burkhardt, Xiaolin Chen, John K Yue, Diana Guo, William Caleb Rutledge, George Lasker, Tarik Tihan, Edward F Chang, Hua Su, Helen Kim, Brian Patrick Walcott, Michael T Lawton. 381 Reductions in Brain Pericytes are Associated with Arteriovenous Malformation Vascular Instability. Neurosurgery. 2017 Sep 1; 64(CN_suppl_1):290-291.
Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H. Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Stroke. 2017 10; 48(10):2881-2884.
Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Stroke. 2017 05; 48(5):1420-1423.
Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y. Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation. Cerebrovasc Dis. 2017; 43(5-6):231-241.
Rui Zhang, Wan Zhu, Li Ma, Man Luo, Lei Zhan, Hua Su. Abstract 125: Increased Endothelial Endoglin Gene Deletion and Co-deletion of EphrinB2 Enhance Brain Arteriovenous Malformation in Mice. Stroke. 2017 Feb 1; 48(suppl_1).
Daniel L Cooke, Van Halbach, Steven Hetts, Matthew Amans, Christopher Dowd, Randall Higashida, Devon Lawson, Jeffrey Nelson, David McCoy, Helen Kim, Tomoki Hashimoto, Zena Werb, Hua Su, Zhengda Sun. Abstract 198: Endovascular Biopsy: in vivo Brain Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Stroke. 2017 Feb 1; 48(suppl_1).
Wan Zhu, Dingquan Zou, Wanqiu Chen, Chen Bao, Rui Zhang, Lei Zhan, Zhengxi Li, Meng Zhang, Ethan Winkler, Michael T. Lawton, Hua Su. Abstract TMP111: Thalidomide and Lenalidomide Treatment Reduces Microhemorrhage in Brain Arteriovenous Malformation in Mice Through Increasing Mural Cell Coverage. Stroke. 2017 Feb 1; 48(suppl_1).
Daniel L Cooke, Helen Kim, Wade Smith, Michael Lawton, Jennifer Clarke, David Saloner, Nerissa Ko, Patricia Sneed, Charles McCulloch, Hua Su. Abstract TP445: Bevacizumab Therapy for Brain Arteriovenous Malformations. Stroke. 2017 Feb 1; 48(suppl_1).
Fanxia Shen, Hua Su. Gene Therapy for Stroke. Translational Research in Stroke. 2017 Jan 1; 441-463.
Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H. Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. Mol Neurobiol. 2017 Dec; 54(10):8278-8286.
Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Correction: Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. PLoS One. 2016; 11(9):e0164214.
Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H. Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Transl Stroke Res. 2016 12; 7(6):488-496.
Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H. Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Angiogenesis. 2016 10; 19(4):451-461.
Liu J, Su H, Qu QM. Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. Neurochem Res. 2016 Sep; 41(9):2311-23.
Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T. Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages. Clin Neuropathol. 2016 May-Jun; 35(3):114-21.
Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. PLoS One. 2016; 11(4):e0153835.
Zhang JY, Deng YN, Zhang M, Su H, Qu QM. SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model. Neurochem Res. 2016 Jul; 41(7):1761-73.
Deng YN, Zeng JY, Su H, Qu QM. Recombinant VLP-Z of JC Polyomavirus: A Novel Vector for Targeting Gene Delivery. Intervirology. 2015; 58(6):363-8.
Huo K, Hashim SI, Yong KL, Su H, Qu QM. Impact and risk factors of post-stroke bone fracture. World J Exp Med. 2016 Feb 20; 6(1):1-8.
Wan Zhu, Fanxia Shen, Shuai Kang, Lei Mao, Zhengda Sun, Dingquan Zou, Rui Zhang, Lei Zhan, John Forsayeth, Hua Su. Abstract 54: Soluble FLT1 Gene Therapy Through Systemic Viral Delivery Reduces the Severity of Mouse Brain Arteriovenous Malformation. Stroke. 2016 Feb 1; 47(suppl_1).
Dingquan Zou, Zhenyi Han, Lei Zhan, Wan Zhu, Shuai Kang, Chen Bao, Alireza Sadighi, Zhao Li, Jeffrey Nelson, Rui Zhang, Hua Su. Abstract WP111: Activation of a7 Nicotinic Acetylcholine Receptor Improves Blood-Brain Barrier Integrity in Mice with Ischemic Stroke and Bone Fracture. Stroke. 2016 Feb 1; 47(suppl_1).
Helen Kim, Ludmila Pawlikowska, Hua Su, William L. Young. 12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations. Stroke. 2016 Jan 1; (N Engl J Med3401999):149-162.e7.
Zhang R, Zhu W, Su H. Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Acta Neurochir Suppl. 2016; 121:29-35.
Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels✩. Biotechnol Rep (Amst). 2015 Sep; 7:157-165.
Ma L, Guo Y, Zhao YL, Su H. Review. The role of macrophage in the pathogenesis of brain arteriovenous malformation. 2015; 1(2):52-56.
Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Gene Ther. 2015 Nov; 22(11):893-900.
Wan Zhu, Fanxia Shen, Lei Zhan, Shuai Kang, Rui Zhang, Dingquan Zou, John Forsayeth, Zhijian Wu, Peter Colosi, Hua Su. 385. Intravenous Delivery of AAV9-CMV-sFLT1 Reduces the Severity of Brain Arteriovenous Malformation Without Causing Significant Side Effects in a Mouse Model. Molecular Therapy. 2015 May 1; 23:s153.
Rui Zhang, Vincent Degos, Shuai Kang, Michael Wong, Lei Zhan, Hua Su. Abstract 191: Persistent Infiltration of Active Microglia in Brain Arteriovenous Malformation Causes Unresolved Inflammation and Lesion Progression. Stroke. 2015 Feb 1; 46(suppl_1).
Lei Mao, Fanxia Shen, Yue He, Lei Zhan, Michael T. Lawton, Hua Su. Abstract W P413: Intravenous Delivery of the AAV9-sFLT Vector Reverses the Phenotype of Spontaneously Developed Brain Arteriovenous Malformation in Mice. Stroke. 2015 Feb 1; 46(suppl_1).
Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8.
Daniel L Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W Hetts, Randall T Higashida, Christopher F Dowd, Van V Halbach, Hua Su, Maythem M Saeed. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interventional Neuroradiology. 2015 Feb 1; 21(1):120-128.
Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J.. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res.2015 Feb;6(1):50-59. 2015; 1(6):50-59.
Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. J Vis Exp. 2015 Jan 27; (95):50472.
Daniel L. Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W. Hetts, Randall T. Higashida, Christopher F. Dowd, Van V. Halbach, Hua Su, Maythem M. Saeed. Endovascular Biopsy: Technical Feasibility of Novel Endothelial Cell Harvesting Devices Assessed in a Rabbit Aneurysm Model. Interventional Neuroradiology. 2015 Jan 1; 21:0.
Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015; 1(22):195-198.
Fanxia Shen, Hua Su. Targeted Gene Therapy for Ischemic Stroke. Gene Delivery and Therapy for Neurological Disorders. 2015 Jan 1; 98:191-202.
Ma L, Guo Y, Zhao YL, Su H. The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation. Int J Hematol Res. 2015 Jan 01; 1(2):52-56.
Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9.
Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H. . Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation. Neuroimmunology and Neuroinflammation. 2014; 1(3):147-152.
Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015 Jan; 22(1):195-8.
Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One. 2014; 9(8):e105711.
Han Z, Li L, Wang L, Degos V, Maze M, Su H. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov; 131(4):498-508.
Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul; 45(7):2101-6.
Chen W, Choi EJ, McDougall CM, Su H. Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Transl Stroke Res. 2014 Jun; 5(3):316-29.
Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One. 2014; 9(2):e88511.
Zhenying Han, Fanxia Shen, Yue He, Vincent Degos, Marine Camus, Mamta Wankhede, Mervyn Maze, William L. Young, Hua Su. Abstract W P98: Activation of a7 Nicotinic Acetylcholine Receptor Reduces Pro-Inflammatory Macrophage and Improves Ischemic Stroke Recovery. Stroke. 2014 Feb 1; 45(suppl_1).
Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H. De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Stroke. 2014 Mar; 45(3):900-2.
Steven W. Hetts, Hua Su, Tarik Tihan, Tomoki Hashimoto, Ludmila Pawlikowska, Michael T. Lawton. Development of the central nervous system vasculature and the pathogenesis of brain arteriovenous malformations. Comprehensive Management of Arteriovenous Malformations of the Brain and Spine. 2014 Jan 1; 1-17.
Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflamm. 2014; 1(3):147-152.
Wanqiu Chen, William L. Young, Hua Su. ERRATUM TO: Induction of Brain Arteriovenous Malformation in the Adult Mouse. Cerebral Angiogenesis. 2014 Jan 1; 1135:e1-e1.
Chen W, Young WL, Su H. Induction of brain arteriovenous malformation in the adult mouse. Methods Mol Biol. 2014; 1135:309-16.
Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408.
Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun; 118(6):1362-72.
Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar; 118(3):527-36.
Lei Mao, Fanxia Shen, Wanqiu Chen, Babatunde Akinpelu, Michael T. Lawton, William L. Young, Hua Su. Abstract TMP116: AAV-sFLT: A Potential Therapeutic Agent for the Treatment of Brain Angiogenic Diseases. Stroke. 2013 Feb 1; 44(suppl_1).
Wanqiu Chen, Yi Guo, Kristine Jun, Mamta Wankhede, Hua Su, William L. Young. Abstract TMP118: Alk1 Deficiency Impairs Mural Cell Recruitment During Brain Angiogenesis. Stroke. 2013 Feb 1; 44(suppl_1).
Fanxia Shen, Vincent Degos, Zhenying Han, Eun-Jung Choi, William L. Young, Hua Su. Abstract TMP69: Endoglin Deficiency Exacerbates Ischemic Brain Injury. Stroke. 2013 Feb 1; 44(suppl_1).
Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Pile-Spellman J, Su H, Young WL. Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation. Stroke. 2013 Mar; 44(3):795-8.
Shen F, Kuo R, Milon-Camus M, Han Z, Jiang L, Young WL, Su H. Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Stroke. 2013 Jan; 44(1):252-4.
Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):305-10.
Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport. 2012 Jul 11; 23(10):627-30.
Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL. Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res. 2012 Jul; 3(Suppl 1):166-73.
Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim, Yongmei Chen, Charles E. McCulloch, Nicholas M. Barbaro, Michael T. Lawton, William L. Young, Gregory J. Bix. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport. 2012 Jul 1; 23(10):627-630.
Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis. 2012; 33(6):540-7.
Walker EJ, Su H, Shen F, Degos V, Amend G, Jun K, Young WL. Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Stroke. 2012 Jul; 43(7):1925-30.
Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL, University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project. Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Stroke. 2012 May; 43(5):1240-6.
Angelika Hoffmann, Jo¨rg Bredno, Michael F Wendland, Nikita Derugin, Jason Hom, Hua Su, Peter T Ohara, William L Young, Max Wintermark. Abstract 2217: Magnetic Resonance Blood-Brain Barrier Permeability Measurements To Predict Hemorrhagic Transformation In A Rat Model Of Ischemic Stroke. Stroke. 2012 Feb 1; 43(suppl_1).
Eun-Jung Choi, Espen J. Walker, Kristine Jun, Robert Kuo, Hua Su, William L. Young. Abstract 3153: Endoglin Deficiency in Bone Marrow is Sufficient to Cause Vascular Dysplasia in the Adult Mouse Brain After VEGF Stimulation. Stroke. 2012 Feb 1; 43(suppl_1).
Wanqiu Chen, Yi Guo, Andrew W. Bollen, Hua Su, William L. Young. Abstract 3169: Reduced PDGFR-beta Expression After Regional Alk1 Deletion and VEGF Stimulation in the Brain is Associated with Reduced Mural Cell Coverage. Stroke. 2012 Feb 1; 43(suppl_1).
Yi Guo, Hua Su, Helen Kim, Michael T. Lawton, Andrew W. Bollen, William L. Young. Abstract 3187: Inflammatory Cell Infiltration Correlates with Hemosiderin Deposition (Intra-lesion Hemorrhage) in Surgical Excised Unruptured Human Brain Arteriovenous Malformations. Stroke. 2012 Feb 1; 43(suppl_1).
Fanxia Shen, Lidan Jiang, Robert Kuo, Vincent Degos, Espen J. Walker, Hua Su, William L. Young. Abstract 3190: Increased Inflammatory Response in Aged Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke. Stroke. 2012 Feb 1; 43(suppl_1).
Espen J. Walker, Hua Su, Fanxia Shen, Kristine Jun, Vincent Degos, Gregory Amend, William L. Young. Abstract 3194: Bevacizumab (Avastin) Crosses the Blood-brain Barrier and Attenuates VEGF-induced Angiogenesis and Vascular Dysplasia in an Adult Mouse Model of Brain Arteriovenous Malformations. Stroke. 2012 Feb 1; 43(suppl_1).
Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329.
Walker EJ, Shen F, Young WL, Su H. Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis. J Vis Exp. 2011 Nov 30; (57).
Walker EJ, Shen F, Young WL, Su H. Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis. J Vis Exp. 2011 Nov 30; (57):e2958.
Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res. 2011 Sep; 2(3):366-75.
Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H. Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2343-51.
Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL. Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol. 2011 Jun; 69(6):954-62.
Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl. 2011; 111:83-92.
Su H, Yang GY. Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol. 2011; 686:429-46.
Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL. Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Stroke. 2011 Feb; 42(2):453-8.
Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12; 330(6006):985-9.
Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010 Oct; 67(4):1029-35.
Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL. VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Transl Stroke Res. 2010 Sep 01; 1(3):197-201.
Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell. 2010 Apr 02; 6(4):323-335.
Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr; 67(4):488-97.
Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27.
Gao P, Shen F, Gabriel RA, Law D, Yang EY, Yang E, Yang GY, Young WL, Su H. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 2009 Nov; 40(11):3596-600.
Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53.
Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 2009 Jul; 66(1):19-27.
Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32.
Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL. Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 2009 Aug; 29(8):1482-90.
Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Stroke. 2009 Mar; 40(3 Suppl):S95-7.
Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2250-6.
Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY. Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2151-7.
Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22.
Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71.
Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1543-51.
Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 03; 133(2):191-7.
Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41.
Su H, Hao Q, Shen F, Zhu Y, Lee CZ, Young WL, Yang GY. Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl. 2008; 105:185-9.
Beiter T, Zimmermann M, Fragasso A, Armeanu S, Lauer UM, Bitzer M, Su H, Young WL, Niess AM, Simon P. Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping. Exerc Immunol Rev. 2008; 14:73-85.
Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008; 105:199-206.
Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther. 2008 Jan; 15(1):30-9.
Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1853-60.
Hua Su, Yuet Wai Kan. Adeno-Associated Viral Vector-Delivered Hypoxia-Inducible Gene Expression in Ischemic Hearts. Cardiac Gene Expression. 2007 Feb 15; 366:331-342.
Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 2007; 366:331-42.
Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci. 2006 Sep 01; 11:3190-8.
Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006 Oct; 37(10):2601-6.
Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW. AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Gene Ther. 2006 Nov; 13(21):1495-502.
Hua Su, Yerem Yeghiazarians, Andrew Lee, Yu Huang, Janice Arakawa-Hoyt, Jianqin Ye, Gina Orcino, William Growssman, Yuet W. Kan. 228. AAV Mediated Hypoxia-Inducible VEGF Expression and Neovascular Formation in Ischemic Pig Myocardium. Molecular Therapy. 2006 Jan 1; 13:s87.
Jennifer Pons, Hua Su, Yu Huang, Y.W. Kan. 343. Vascular Endothelial Growth Factor Prevents Bone Marrow Derived-Mesenchymal Stem Cell Senescence In Vitro. Molecular Therapy. 2006 Jan 1; 13:s131.
Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16280-5.
Chang DS, Su H, Tang GL, Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM. Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther. 2003 Jan; 7(1):44-51.
Su H, Arakawa-Hoyt J, Kan YW. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9480-5.
Su H, Lu R, Kan YW. Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13801-6.
Su H, Lu R, Ding R, Kan YW. Adeno-associated viral-mediated gene transfer to hepatoma: thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated than in GCV-treated animals. Mol Ther. 2000 Jun; 1(6):509-15.
Su H, Lu R, Chang JC, Kan YW. Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13891-6.
Kypta RM, Su H, Reichardt LF. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J Cell Biol. 1996 Sep; 134(6):1519-29.
Su H, Chang JC, Xu SM, Kan YW. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. 1996 Mar 01; 7(4):463-70.
Su H, Lau YF. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Am J Hum Genet. 1993 Jan; 52(1):24-38.
Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Mol Reprod Dev. 1992 Nov; 33(3):252-8.
Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. J Reprod Immunol. 1992 Apr; 21(3):275-91.