Biography My research focuses on identifying risk factors that predispose younger individuals to stroke and cardiovascular disease. Currently, my group is studying the genetic epidemiology of hemorrhagic stroke and modifiers of outcome after hemorrhage or treatment in patients with brain vascular malformations. I collaborate closely with a multidisciplinary group of investigators at the UCSF Center for Cerebrovascular Research, Kaiser Permanente Division of Research in Oakland, Duke University, and the University of New Mexico. Several large case-cohort studies of brain arteriovenous malformations, subarachnoid hemorrhage, cerebral cavernous malformations, and hereditary hemorrhagic telangiectasia are underway. These vascular-related disorders, while distinct, share to some degree similar clinical symptoms and features. We are taking both candidate gene and genome-wide approaches to identify genetic factors associated with disease susceptibility and progression, including SNP and expression arrays, and next-gen sequencing. Additional research interests include investigating approaches for population stratification, multivariate phenotypes, admixture mapping, and gene-gene and gene-environment interactions. Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Research Education 2019 - Diversity, Equity, and Inclusion Champion Training, University of California Publications Arterial Spin-Labeling MR Imaging in the Detection of Intracranial Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia. Alyafaie A, Han W, Li Y, Vydro SA, Vella M, Truong TL, Park L, Langston D, Kim H, Conrad MB, Hetts SW Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study. Islam F, Lisoway A, Oh ES, Fiori LM, Magarbeh L, Elsheikh SSM, Kim HK, Kloiber S, Kennedy JL, Frey BN, Milev R, Soares CN, Parikh SV, Placenza F, Hassel S, Taylor VH, Leri F, Blier P, Uher R, Farzan F, Lam RW, Turecki G, Foster JA, Rotzinger S, Kennedy SH, Müller DJ Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling. Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia. Beslow LA, Vossough A, Kim H, Nelson J, Lawton MT, Pollak J, Lin DDM, Ratjen F, Hammill AM, Hetts SW, Gossage JR, Whitehead KJ, Faughnan ME, Krings T, Brain Vascular Malformation Consortium HHT Investigator Group De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia. Beslow LA, Krings T, Kim H, Hetts SW, Lawton MT, Ratjen F, Whitehead KJ, Gossage JR, McCulloch CE, Clancy M, Bagheri N, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group Abstract TP6: Identification of Circulating Epigenetic Biomarkers for Seizure in Brain Arteriovenous Malformation by Methylome Profiling. Peter Park, Jeffrey Nelson, Christine K Fox, Adam Numis, Nerissa Ko, Ethan Winkler, Charles McCulloch, Helen Kim, Shantel Weinsheimer Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations. Ayata C, Kim H, Morrison L, Liao JK, Gutierrez J, Lopez-Toledano M, Carrazana E, Rabinowicz AL, Awad IA Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Shabani Z, Schuerger J, Zhu X, Tang C, Ma L, Yadav A, Liang R, Press K, Weinsheimer S, Schmidt A, Wang C, Sekhar A, Nelson J, Kim H, Su H Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse. Zahra Shabani, Joana Schuerger, Xiaonan Zhu, Chaoliang Tang, Li Ma, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Calvin Wang, Abinav Sekhar, Jeffrey Nelson, Helen Kim, Hua Su Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome. Flemming KD, Kim H, Hage S, Mandrekar J, Kinkade S, Girard R, Torbey M, Huang J, Huston J, Shu Y, Lanzino G, Selwyn R, Hart B, Mabray M, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson R, Koenig JI, Carroll T, Hanley D, Awad I Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling. Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee NA, Treine K, Ostapkovich N, Wang Y, Thompson RE, Koenig JI, Carroll T, Hanley DF, Awad IA Reply to Eker et al. Comment on "Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704". Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME Reply to Eker et al. Comment on “Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704”. Alexandra Kilian, Giuseppe A. Latino, Andrew J. White, Felix Ratjen, Jamie McDonald, Kevin J. Whitehead, James R. Gossage, Timo Krings, Michael T. Lawton, Helen Kim, Marie E. Faughnan, The Brain Vascular Malformation Consortium HHT Investigator Group Cross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia. Kim HK, Gonçalves VF, Husain MI, Müller DJ, Mulsant BH, Zai G, Kloiber S Factors Associated with Unfavorable Clinical Presentations in Patients with Ruptured BrainArteriovenous Malformations. Garcia JH, Carrete L, Rutledge WC, Raygor KP, Winkler EA, Pereira MP, Nelson J, Kim H, Cooke DL, Hetts SW, Lawton MT, Abla AA Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling. Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar R, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson RE, Mendoza-Puccini C, Koenig J, Carroll T, Hanley DF, Awad IA Exploring effects of atmospheric conditions in hereditary hemorrhagic telangiectasia. Yusuf HM, Rasheed A, Hetts S, Kim H, Loftus P, Conrad M An analysis of sex differences in pulmonary arteriovenous malformation presentation, complications and management in a large, multinational registry of patients with hereditary haemorrhagic telangiectasia. Tuff-Gordon E, Faughnan ME, Kim H, Lawton MT, Vozoris NT, Brain Vascular Malformation Consortium HHT Investigator Group, Brain Vascular Malformation Consortium HHT Investigator Group A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI. Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME A comparison of incidental and symptomatic unruptured brain arteriovenous malformations in children. Lu AY, Winkler EA, Garcia JH, Raygor KP, Fullerton HJ, Fox CK, Kim H, Auguste KI, Sun PP, Hetts SW, Lawton MT, Abla AA, Gupta N Abstract 52: Prevalence Of Somatic Activating Kras Mutations In Pediatric And Adult Sporadic Brain Arteriovenous Malformations. Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim Abstract 53: Long-term Treatment Risk Of Hemorrhage In Unruptured Brain Arteriovenous Malformation Patients. Helen Kim, Jeffrey Nelson, Rustam Al-Shahi Salman, Kelly Flemming, Christopher Hess, Steven W Hetts, Päivi Koroknay-Pál, Aki Laakso, Giuseppe S Lanzino, Michael Lawton, Charles McCulloch, Nicole Moayeri, Jay P Mohr, Michael Morgan, Marco Stefani, Jonathan Zaroff, Yuanli Zhao Abstract TMP17: Polymorphisms In DNA Methylated Genes And Risk Of Intracranial Hemorrhage In Brain Arteriovenous Malformation Patients. Thinzar Zaw, Shantel Weinsheimer, Jeffrey Nelson, Charles McCulloch, Jonathan Zaroff, Helen Kim Abstract TP157: Interleukin Plasma Levels And Risk Of Hemorrhage In Pediatric Brain Arteriovenous Malformation Patients. Shweta A Chawla, Shantel Weinsheimer, Jeffrey Nelson, Charles McCulloch, Adib Abla, Nalin Gupta, Daniel L Cooke, Steven Hetts, David Saloner, Yi Li, Christine K Fox, Heather J Fullerton, Helen Kim Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation. Weinsheimer S, Nelson J, Abla AA, Ko NU, Tsang C, Okoye O, Zabramski JM, Akers A, Zafar A, Mabray MC, Hart BL, Morrison L, McCulloch CE, Kim H, Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group * Identifying racial disparities in hereditary hemorrhagic telangiectasia. Yusuf H, Rasheed A, Kim H, Conrad MB, Hetts SW Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size. Ananiadis T, Faughnan ME, Clark D, Prabhudesai V, Kim H, Lawton MT, Vozoris NT, Brain Vascular Malformation Consortium HHT Investigator Group Machine learning for predicting hemorrhage in pediatric patients with brain arteriovenous malformation. Saggi S, Winkler EA, Ammanuel SG, Morshed RA, Garcia JH, Young JS, Semonche A, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Abla A, Lawton MT, Gupta N A single-cell atlas of the normal and malformed human brain vasculature. Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ Validation of the Ruptured Arteriovenous Malformation Grading Scale in a pediatric cohort. Garcia JH, Rutledge C, Winkler EA, Carrete L, Morshed RA, Lu AY, Saggi S, Fox CK, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Lawton MT, Gupta N, Abla AA Childhood stroke. Sporns PB, Fullerton HJ, Lee S, Kim H, Lo WD, Mackay MT, Wildgruber M Endoluminal Biopsy for Molecular Profiling of Human Brain Vascular Malformations. Winkler E, Wu D, Gil E, McCoy D, Narsinh K, Sun Z, Mueller K, Ross J, Kim H, Weinsheimer S, Berger M, Nowakowski T, Lim D, Abla A, Cooke D Maximizing Brain Health After Hemorrhagic Stroke: Bugher Foundation Centers of Excellence. Sheth KN, Anderson CD, Biffi A, Dlamini N, Falcone GJ, Fox CK, Fullerton HJ, Greenberg SM, Hemphill JC, Kim A, Kim H, Ko NU, Roland JL, Sansing LH, van Veluw SJ, Rosand J Quantification metrics for telangiectasia using optical coherence tomography. Cardinell JL, Ramjist JM, Chen C, Shi W, Nguyen NQ, Yeretsian T, Choi M, Chen D, Clark DS, Curtis A, Kim H, Faughnan ME, Yang VXD, Brain Vascular Malformation Consortium HHT Investigator Group Abstract 109: Biological Pathways Enriched For Genes Associated With Lesion Burden In Cerebral Cavernous Malformation. Aditya Sriram, Shantel Weinsheimer, Jeffrey Nelson, Marc Mabray, Joseph M Zabramski, Amy Akers, Blaine Hart, Leslie Morrison, Charles E McCulloch, Helen Kim 12 Genetics and Vascular Biology of Brain Vascular Malformations. Helen Kim, Ludmila Pawlikowska, Hua Su A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). Romuald Girard, Yan Li, Agnieszka Stadnik, Robert Shenkar, Nicholas Hobson, Sharbel Romanos, Abhinav Srinath, Thomas Moore, Rhonda Lightle, Abdallah Shkoukani, Amy Akers, Timothy Carroll, Gregory A Christoforidis, James I Koenig, Cornelia Lee, Kristina Piedad, Steven M Greenberg, Helen Kim, Kelly D Flemming, Yuan Ji, Issam A Awad Factors associated with seizures at initial presentation in pediatric patients with cerebral arteriovenous malformations. Garcia JH, Winkler EA, Morshed RA, Lu A, Ammanuel SG, Saggi S, Wang EJ, Braunstein S, Fox CK, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Lawton MT, Abla AA, Gupta N Seizure Incidence Rates in Children and Adults With Familial Cerebral Cavernous Malformations. Fox CK, Nelson J, McCulloch CE, Weinsheimer S, Pawlikowska L, Hart B, Mabray MC, Zafar A, Morrison L, Zabramski JM, Akers A, Kim H Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project. Kim H, Flemming KD, Nelson JA, Lui A, Majersik JJ, Cruz MD, Zabramski J, Trevizo O, Lanzino G, Zafar A, Torbey M, Mabray MC, Robinson M, Narvid J, Lupo J, Thompson RE, Hanley DF, McBee N, Treine K, Ostapkovich N, Stadnik A, Piedad K, Hobson N, Carroll T, Shkoukani A, Carrión-Penagos J, Mendoza-Puccini C, Koenig JI, Awad I Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation. Choksi F, Weinsheimer S, Nelson J, Pawlikowska L, Fox CK, Zafar A, Mabray MC, Zabramski J, Akers A, Hart BL, Morrison L, McCulloch CE, Kim H Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations. Wetzel-Strong SE, Weinsheimer S, Nelson J, Pawlikowska L, Clark D, Starr MD, Liu Y, Kim H, Faughnan ME, Nixon AB, Marchuk DA Presence of Vessel Wall Hyperintensity in Unruptured Arteriovenous Malformations on Vessel Wall Magnetic Resonance Imaging: Pilot Study of AVM Vessel Wall "Enhancement". Eisenmenger LB, Junn JC, Cooke D, Hetts S, Zhu C, Johnson KM, Manunga JM, Saloner D, Hess C, Kim H Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype. Gao S, Nelson J, Weinsheimer S, Winkler EA, Rutledge C, Abla AA, Gupta N, Shieh JT, Cooke DL, Hetts SW, Tihan T, Hess CP, Ko N, Walcott BP, McCulloch CE, Lawton MT, Su H, Pawlikowska L, Kim H Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation. Keränen S, Suutarinen S, Mallick R, Laakkonen JP, Guo D, Pawlikowska L, Jahromi BR, Rauramaa T, Ylä-Herttuala S, Marchuk D, Krings T, Koivisto T, Lawton M, Radovanovic I, Kim H, Faughnan ME, Frösen J Intermediate-grade brain arteriovenous malformations and the boundary of operability using the supplemented Spetzler-Martin grading system. Catapano JS, Frisoli FA, Nguyen CL, Labib MA, Cole TS, Baranoski JF, Kim H, Spetzler RF, Lawton MT Review of treatment and therapeutic targets in brain arteriovenous malformation. Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H Spetzler-Martin Grade III Arteriovenous Malformations: A Multicenter Propensity-Adjusted Analysis of the Effects of Preoperative Embolization. Catapano JS, Frisoli FA, Nguyen CL, Wilkinson DA, Majmundar N, Cole TS, Baranoski JF, Whiting AC, Kim H, Ducruet AF, Albuquerque FC, Cooke DL, Spetzler RF, Lawton MT Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation. Muster R, Ko N, Smith W, Su H, Dickey MA, Nelson J, McCulloch CE, Sneed PK, Clarke JL, Saloner DA, Eisenmenger L, Kim H, Cooke DL Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation. Rachel Muster, Nerissa Ko, Wade Smith, Hua Su, Melissa A Dickey, Jeffrey Nelson, Charles E McCulloch, Patricia K Sneed, Jennifer L Clarke, David A Saloner, Laura Eisenmenger, Helen Kim, Daniel L Cooke Maternal and Fetal Outcomes in Women with Brain Arteriovenous Malformation Rupture during Pregnancy. Yan KL, Ko NU, Hetts SW, Weinsheimer S, Abla AA, Lawton MT, Kim H A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IA Systemic and CNS manifestations of inherited cerebrovascular malformations. Hart BL, Mabray MC, Morrison L, Whitehead KJ, Kim H Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O, Gentric JC, Shotar E, Eugène F, Desal H, Winsvold BS, Børte S, Johnsen MB, Brumpton BM, Sandvei MS, Willer CJ, Hveem K, Zwart JA, Verschuren WMM, Friedrich CM, Hirsch S, Schilling S, Dauvillier J, Martin O, HUNT All-In Stroke, China Kadoorie Biobank Collaborative Group, BioBank Japan Project Consortium, ICAN Study Group, CADISP Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, International Stroke Genetics Consortium (ISGC), Jones GT, Bown MJ, Ko NU, Kim H, Coleman JRI, Breen G, Zaroff JG, Klijn CJM, Malik R, Dichgans M, Sargurupremraj M, Tatlisumak T, Amouyel P, Debette S, Rinkel GJE, Worrall BB, Pera J, Slowik A, Gaál-Paavola EI, Niemelä M, Jääskeläinen JE, von Und Zu Fraunberg M, Lindgren A, Broderick JP, Werring DJ, Woo D, Redon R, Bijlenga P, Kamatani Y, Veldink JH, Ruigrok YM Interrater Reliability in the Measurement of Flow Characteristics on Color-Coded Quantitative DSA of Brain AVMs. Narsinh KH, Mueller K, Nelson J, Massachi J, Murph DC, Copelan AZ, Hetts SW, Halbach VV, Higashida RT, Abla AA, Amans MR, Dowd CF, Kim H, Cooke DL Brain Arteriovenous Malformation Recurrence After Apparent Microsurgical Cure: Increased Risk in Children Who Present With Arteriovenous Malformation Rupture. Copelan A, Drocton G, Caton MT, Smith ER, Cooke DL, Nelson J, Abla AA, Fox C, Amans MR, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Kim H, Fullerton HJ, Gupta N, Hetts SW, UCSF Center For Cerebrovascular Research and UCSF Pediatric Brain Center Genotype-Phenotype Correlations in Children with HHT. Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, the Brain Vascular Malformation Consortium HHT Investigator Group Medical management with interventional therapy versus medical management alone for unruptured brain arteriovenous malformations (ARUBA): final follow-up of a multicentre, non-blinded, randomised controlled trial. Mohr JP, Overbey JR, Hartmann A, Kummer RV, Al-Shahi Salman R, Kim H, van der Worp HB, Parides MK, Stefani MA, Houdart E, Libman R, Pile-Spellman J, Harkness K, Cordonnier C, Moquete E, Biondi A, Klijn CJM, Stapf C, Moskowitz AJ, ARUBA co-investigators Concurrent Presentation of Brain Arteriovenous Malformation, Peripheral Arteriovenous Malformation, and Cerebellar Astrocytoma: Case report. Ayushi Gautam, Zhengda Sun, Ethan Winkler, Hua Su, Tim McCalmont, Helen Kim, Tarik Tihan, William Y. Hoffman, Chris F. Dowd, Ilona J. Frieden, Daniel L. Cooke Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA Bringing high-grade arteriovenous malformations under control: clinical outcomes following multimodality treatment in children. Winkler EA, Lu A, Morshed RA, Yue JK, Rutledge WC, Burkhardt JK, Patel AB, Ammanuel SG, Braunstein S, Fox CK, Fullerton HJ, Kim H, Cooke D, Hetts SW, Lawton MT, Abla AA, Gupta N High-Flow Vascular Malformations in Children. Morshed RA, Winkler EA, Kim H, Braunstein S, Cooke DL, Hetts SW, Abla AA, Fullerton HJ, Gupta N Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report. Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity. Choquet H, Kim H Angiopoietin-2 predicts morbidity in adults with Fontan physiology. Shirali AS, Lluri G, Guihard PJ, Conrad MB, Kim H, Pawlikowska L, Boström KI, Iruela-Arispe ML, Aboulhosn JA Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML Cost determinants in management of brain arteriovenous malformations. Rutledge C, Nelson J, Lu A, Nisson P, Jonzzon S, Winkler EA, Cooke D, Abla AA, Lawton MT, Kim H Effect of Simvastatin on Permeability in Cerebral Cavernous Malformation Type 1 Patients: Results from a Pilot Small Randomized Controlled Clinical Trial. Mabray MC, Caprihan A, Nelson J, McCulloch CE, Zafar A, Kim H, Hart BL, Morrison L The effect of preoperative embolization and flow dynamics on resection of brain arteriovenous malformations. Donzelli GF, Nelson J, McCoy D, McCulloch CE, Hetts SW, Amans MR, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Kim H, Cooke DL Familial Cerebral Cavernous Malformations. Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH). Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Koskimäki J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IA A novel proposed grading system for cerebellar arteriovenous malformations. Nisson PL, Fard SA, Walter CM, Johnstone CM, Mooney MA, Tayebi Meybodi A, Lang M, Kim H, Jahnke H, Roe DJ, Dumont TM, Lemole GM, Spetzler RF, Lawton MT Abstract TP578: Comparison of Demographic, Clinical, and Angiographic Characteristics Between Pediatric and Adult HHT Patients With Brain AVMs. Ayushi Gautam, Jeffrey Nelson, Helen Kim, Steven Hetts Assessing the Hereditary Hemorrhagic Telangiectasia Algorithms in a Community-Based Patient Population. Saparia T, Faughnan ME, Schneider JL, Almers LM, Chow N, Grosse SD, Kim H, Zaroff JG Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT Microsurgical resection of brain arteriovenous malformations in the elderly: outcomes analysis and risk stratification. Burkhardt JK, Lasker GF, Winkler EA, Kim H, Lawton MT Does eloquence subtype influence outcome following arteriovenous malformation surgery? Mascitelli JR, Yoon S, Cole TS, Kim H, Lawton MT The Unique Features and Outcomes of Microsurgically Resected Cerebellar Arteriovenous Malformations. Nisson PL, Fard SA, Meybodi AT, Mooney MA, Kim H, Jahnke H, Walter CM, Dumont TM, Lemole GM, Lawton MT, Spetzler RF Evaluation of Angioarchitectural Features of Unruptured Brain Arteriovenous Malformation by Susceptibility Weighted Imaging. Wu CX, Ma L, Chen XZ, Chen XL, Chen Y, Zhao YL, Hess C, Kim H, Jin HW, Ma J Frequency and characteristics associated with inherited thrombophilia in patients with intracranial dural arteriovenous fistula. LaHue SC, Kim H, Pawlikowska L, Nelson J, Cooke DL, Hetts SW, Singh V Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia. Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Kim H, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study. Alexander MD, Hippe DS, Cooke DL, Hallam DK, Hetts SW, Kim H, Lawton MT, Sekhar LN, Kim LJ, Ghodke BV Predictors of intracranial hemorrhage volume and distribution in brain arteriovenous malformation. Yu JF, Nicholson AD, Nelson J, Alexander MD, Tse SH, Hetts SW, Hemphill JC, Kim H, Cooke DL Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study. Meybodi AT, Kim H, Nelson J, Hetts SW, Krings T, terBrugge KG, Faughnan ME, Lawton MT, Brain Vascular Malformation Consortium HHT Investigator Group Early Hemodynamic Changes Based on Initial Color-Coding Angiography as a Predictor for Developing Subsequent Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage. Burkhardt JK, Chen X, Winkler EA, Weiss M, Yue JK, Cooke DL, Kim H, Lawton MT Pial Artery Supply as an Anatomic Risk Factor for Ischemic Stroke in the Treatment of Intracranial Dural Arteriovenous Fistulas. Hetts SW, Yen A, Cooke DL, Nelson J, Jolivalt P, Banaga J, Amans MR, Dowd CF, Higashida RT, Lawton MT, Kim H, Halbach VV Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z Functional impairments for outcomes in a randomized trial of unruptured brain AVMs. Mohr JP, Overbey JR, von Kummer R, Stefani MA, Libman R, Stapf C, Parides MK, Pile-Spellman J, Moquete E, Moy CS, Vicaut E, Moskowitz AJ, Harkness K, Cordonnier C, Biondi A, Houdart E, Berkefeld J, Klijn CJM, Barreau X, Kim H, Hartmann A, International ARUBA Investigators Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H Synopsis of guidelines for the clinical management of cerebral cavernous malformations: Consensus recommendations based on systematic literature review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel. Amy Akers, Rustam Al-Shahi Salman, Issam A. Awad, Kristen Dahlem, Kelly Flemming, Blaine Hart, Helen Kim, Ignacio Jusue-Torres, Douglas Kondziolka, Cornelia Lee, Leslie Morrison, Daniele Rigamonti, Tania Rebeiz, Elisabeth Tournier-Lasserve, Darrel Waggoner, Kevin Whitehead Prevalence and predictors of anemia in hereditary hemorrhagic telangiectasia. Kasthuri RS, Montifar M, Nelson J, Kim H, Lawton MT, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations. Zou X, Hart BL, Mabray M, Bartlett MR, Bian W, Nelson J, Morrison LA, McCulloch CE, Hess CP, Lupo JM, Kim H Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel. Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K Delayed Venous Drainage in Ruptured Arteriovenous Malformations Based on Quantitative Color-Coded Digital Subtraction Angiography. Burkhardt JK, Chen X, Winkler EA, Cooke DL, Kim H, Lawton MT Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition. Strickland CD, Eberhardt SC, Bartlett MR, Nelson J, Kim H, Morrison LA, Hart BL Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation. Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y Abstract 120: Radiocarbon Birth Dating of Cerebral Arteriovenous Malformations. Daniel L Cooke, Meike Halberkann, Christian Matzenauer, Helen Kim, Michael Lawton, Kerim Beseoglu, Rita Dreier, Bruce Buchholz, R. Loch Macdonald, Nima Etminan Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study. Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, Lafer B Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages. Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV Clinical Impairment in Patients Followed with or without Interventional Therapy in a Randomized Trial of Unruptured Brain AVMs (ARUBA) (S7.007). J. Mohr, Jessica Overbey, Christian Stapf, Andreas Hartmann, Marco Stefani, Michael Parides, Ellen Moquete, Claudia Moy, E Vicaut, Alan Moskowitz, R. Al-Shahi Salman, E. Houdart, Charlotte Cordonnier, Ruediger von Kummer, Alessandra Biondi, J. Berkefeld, C. Klijn, Kristy Harkness, Richard Libman, X Barreau, Helen Kim Abstract 53: Variation in DNA Mismatch Repair Genes Nominally Associated With Severity of Cerebral Cavernous Malformation Type 1. Hélène Choquet, Ludmila Pawlikowska, Jeffrey Nelson, Charles E. McCulloch, Amy Akers, Yasir Khan, Blaine Hart, Leslie Morrison, Helen Kim Abstract WP436: Comparing Risk of Stroke and Death in Treated and Untreated Patients With Unruptured Brain Arteriovenous Malformations (BAVM). Helen Kim, Jeffrey Nelson, Charles E McCulloch, Michael T Lawton, Jay P Mohr, Christian Stapf, Rustam Al-Shahi Salman Genome-wide association study of sporadic brain arteriovenous malformations. Weinsheimer S, Bendjilali N, Nelson J, Guo DE, Zaroff JG, Sidney S, McCulloch CE, Al-Shahi Salman R, Berg JN, Koeleman BP, Simon M, Bostroem A, Fontanella M, Sturiale CL, Pola R, Puca A, Lawton MT, Young WL, Pawlikowska L, Klijn CJ, Kim H, GEN-AVM Consortium Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF 107 The Role of Oxidative Stress in Cerebral Cavernous Malformation (CCM) Pathogenesis: From Disease Mechanisms toward Therapeutic Approaches. Eliana Trapani, Saverio Marchi, Helene Choquet, Luca Goitre, Andrea Moglia, Cinzia Antognelli, Simona Delle Monache, Lorenza Trabalzini, Helen Kim, Paolo Pinton, Saverio Francesco Retta Harms associated with single unit perioperative transfusion: retrospective population based analysis. Whitlock EL, Kim H, Auerbach AD Brain arteriovenous malformations. Lawton MT, Rutledge WC, Kim H, Stapf C, Whitehead KJ, Li DY, Krings T, terBrugge K, Kondziolka D, Morgan MK, Moon K, Spetzler RF Silent arteriovenous malformation hemorrhage and the recognition of "unruptured" arteriovenous malformation patients who benefit from surgical intervention. Abla AA, Nelson J, Kim H, Hess CP, Tihan T, Lawton MT Genetics of cerebral cavernous malformations: current status and future prospects. Choquet H, Pawlikowska L, Lawton MT, Kim H Surgical treatment of cerebral cavernous malformations. Davies JM, Kim H, Lawton MT Hemorrhage rates from brain arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia. Kim H, Nelson J, Krings T, terBrugge KG, McCulloch CE, Lawton MT, Young WL, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Young WL, Kim H, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL Current surgical results with low-grade brain arteriovenous malformations. Potts MB, Lau D, Abla AA, Kim H, Young WL, Lawton MT, UCSF Brain AVM Study Project Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage. Alexander MD, Cooke DL, Nelson J, Guo DE, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H, Hetts SW Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations. Krings T, Kim H, Power S, Nelson J, Faughnan ME, Young WL, terBrugge KG, Brain Vascular Malformation Consortium HHT Investigator Group Increased number of white matter lesions in patients with familial cerebral cavernous malformations. Golden MJ, Morrison LA, Kim H, Hart BL Brainstem arteriovenous malformations: anatomical subtypes, assessment of "occlusion in situ" technique, and microsurgical results. Han SJ, Englot DJ, Kim H, Lawton MT Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, Stapleton C, Walcott BP, Ogilvy CS, Spetzler RF, Lawton MT Severity score for hereditary hemorrhagic telangiectasia. Latino GA, Kim H, Nelson J, Pawlikowska L, Young W, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group Viewpoints on the ARUBA trial. Mohr JP, Hartmann A, Kim H, Pile-Spellman J, Stapf C Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity. Choquet H, Pawlikowska L, Nelson J, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H, Brain Vascular Malformation Consortium (BVMC) Study A treatment paradigm for high-grade brain arteriovenous malformations: volume-staged radiosurgical downgrading followed by microsurgical resection. Abla AA, Rutledge WC, Seymour ZA, Guo D, Kim H, Gupta N, Sneed PK, Barani IJ, Larson D, McDermott MW, Lawton MT The natural history of AVM hemorrhage in the posterior fossa: comparison of hematoma volumes and neurological outcomes in patients with ruptured infra- and supratentorial AVMs. Abla AA, Nelson J, Rutledge WC, Young WL, Kim H, Lawton MT Treatment and outcomes of ARUBA-eligible patients with unruptured brain arteriovenous malformations at a single institution. Rutledge WC, Abla AA, Nelson J, Halbach VV, Kim H, Lawton MT Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. Kremer PH, Koeleman BP, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, Zaroff JG, Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA, Veldink JH, Kim H, Klijn CJ Untreated brain arteriovenous malformation: patient-level meta-analysis of hemorrhage predictors. Kim H, Al-Shahi Salman R, McCulloch CE, Stapf C, Young WL, MARS Coinvestigators Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations. Rutledge WC, Ko NU, Lawton MT, Kim H Endoglin deficiency impairs stroke recovery. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms. Bendjilali N, Nelson J, Weinsheimer S, Sidney S, Zaroff JG, Hetts SW, Segal M, Pawlikowska L, McCulloch CE, Young WL, Kim H Influence of patient age on angioarchitecture of brain arteriovenous malformations. Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation. Choquet H, Nelson J, Pawlikowska L, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformation. Bendjilali N, Kim H, Weinsheimer S, Guo DE, Kwok PY, Zaroff JG, Sidney S, Lawton MT, McCulloch CE, Koeleman BP, Klijn CJ, Young WL, Pawlikowska L Brain Vascular Malformation Consortium: Overview, Progress and Future Directions. Akers AL, Ball KL, Clancy M, Comi AM, Faughnan ME, Gopal-Srivastava R, Jacobs TP, Kim H, Krischer J, Marchuk DA, McCulloch CE, Morrison L, Moses M, Moy CS, Pawlikowska L, Young WL Abstract 188: Clinical Factors Associated with Lesion Count in Familial Cerebral Cavernous Malformation Type 1 Patients with the Common Hispanic Mutation. He´le`ne Choquet, Jeff Nelson, Ludmila Pawlikowska, Amy Akers, Beth Baca, Yasir Khan, Blaine Hart, Leslie Morrison, Helen Kim Abstract TMP30: Genetic Variants on 9p21.3 are Associated with Brain Arteriovenous Malformations with Associated Arterial Aneurysms. Nasrine Bendjilali, Jeffrey Nelson, Shantel Weinsheimer, Stephen Sidney, Jonathan G Zaroff, Mark Segal, Ludmila Pawlikowska, Charles E McCulloch, William L Young, Helen Kim Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhage. Zaroff JG, Leong J, Kim H, Young WL, Cullen SP, Rao VA, Sorel M, Quesenberry CP, Sidney S Cerebellar arteriovenous malformations: anatomic subtypes, surgical results, and increased predictive accuracy of the supplementary grading system. Rodríguez-Hernández A, Kim H, Pourmohamad T, Young WL, Lawton MT, University of California, San Francisco Arteriovenous Malformation Study Project Polymorphisms in ACVRL1 and endoglin genes are not associated with sporadic and HHT-related brain AVMs in Dutch patients. Boshuisen K, Brundel M, de Kovel CGF, Letteboer TG, Rinkel GJE, Westermann CJJ, Kim H, Pawlikowska L, Koeleman BPC, Klijn CJM Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: gene-phenotype correlations. Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, Terbrugge KG, White RI G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation. Weinsheimer S, Brettman AD, Pawlikowska L, Wu DC, Mancuso MR, Kuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE, Young WL, Kuo C, Kim H Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery. Kim H, Pourmohamad T, Westbroek EM, McCulloch CE, Lawton MT, Young WL Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation. Westbroek EM, Pawlikowska L, Lawton MT, McCulloch CE, Young WL, Kim H Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim, Yongmei Chen, Charles E. McCulloch, Nicholas M. Barbaro, Michael T. Lawton, William L. Young, Gregory J. Bix The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA, DOGMATIC Study Investigators An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling. Degos V, Apfel CC, Sanchez P, Colonne C, Renuit I, Clarençon F, Nouet A, Boch AL, Pourmohamad T, Kim H, Gourraud PA, Young WL, Puybasset L Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL, University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project Abstract 3187: Inflammatory Cell Infiltration Correlates with Hemosiderin Deposition (Intra-lesion Hemorrhage) in Surgical Excised Unruptured Human Brain Arteriovenous Malformations. Yi Guo, Hua Su, Helen Kim, Michael T. Lawton, Andrew W. Bollen, William L. Young Abstract 3242: Brain-derived Neurotrophic Factor Val66Met Polymorphism is Associated with Worsening of Functional Outcome in Patients Undergoing Resection of Unruptured Brain Arteriovenous Malformations. Erick M Westbroek, Ludmila Pawlikowska, Michael T Lawton, Charles E McCulloch, William L Young, Helen Kim Classification schemes for arteriovenous malformations. Davies JM, Kim H, Young WL, Lawton MT Gene expression profiling of blood in brain arteriovenous malformation patients. Weinsheimer SM, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagic telangiectasia: quantitative assessment. Bharatha A, Faughnan ME, Kim H, Pourmohamad T, Krings T, Bayrak-Toydemir P, Pawlikowska L, McCulloch CE, Lawton MT, Dowd CF, Young WL, Terbrugge KG Three Authors Reply. Helen Kim, Charles E. McCulloch, William L. Young Arteriovenous malformation in the adult mouse brain resembling the human disease. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations. Mikhak B, Weinsheimer S, Pawlikowska L, Poon A, Kwok PY, Lawton MT, Chen Y, Zaroff JG, Sidney S, McCulloch CE, Young WL, Kim H 12 Genetics and Vascular Biology of Brain Vascular Malformations. Helen Kim, Ludmila Pawlikowska, William L. Young Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture. Kim H, McCulloch CE, Johnston SC, Lawton MT, Sidney S, Young WL A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery. Lawton MT, Kim H, McCulloch CE, Mikhak B, Young WL Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population. Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol AS, Zaroff JG, Young WL Biology of vascular malformations of the brain. Leblanc GG, Golanov E, Awad IA, Young WL, Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations. Weinsheimer S, Kim H, Pawlikowska L, Chen Y, Lawton MT, Sidney S, Kwok PY, McCulloch CE, Young WL Race\ethnicity and outcome after traumatic brain injury at a single, diverse center. Sorani MD, Lee M, Kim H, Meeker M, Manley GT Soluble endoglin modulates aberrant cerebral vascular remodeling. Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity. Sanchez-Mejia RO, McDermott MW, Tan J, Kim H, Young WL, Lawton MT Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok PY, Young WL Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL Population stratification in a case-control study of brain arteriovenous malformation in Latinos. Kim H, Hysi PG, Pawlikowska L, Choudhry S, González Burchard E, Kwok PY, Sidney S, McCulloch CE, Young WL Genome-wide linkage scan for the metabolic syndrome: the GENNID study. Edwards KL, Hutter CM, Wan JY, Kim H, Monks SA Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance. Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL, UCSF BAVM Study Project Arteriovenous malformation. Young WL, Kwok PY, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk DA Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: the Collaborative Study on the Genetics of Alcoholism. Kim H, Hutter CM, Monks SA, Edwards KL The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. Dreisbach AW, Japa S, Sigel A, Parenti MB, Hess AE, Srinouanprachanh SL, Rettie AE, Kim H, Farin FM, Hamm LL, Lertora JJ Family history as a risk factor for stroke in young women. Kim H, Friedlander Y, Longstreth WT, Edwards KL, Schwartz SM, Siscovick DS Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. Meyer-Olson D, Shoukry NH, Brady KW, Kim H, Olson DP, Hartman K, Shintani AK, Walker CM, Kalams SA Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study. Goode EL, Badzioch MD, Kim H, Gagnon F, Rozek LS, Edwards KL, Jarvik GP, Framingham Heart Study Family history of diabetes as a potential public health tool. Harrison TA, Hindorff LA, Kim H, Wines RC, Bowen DJ, McGrath BB, Edwards KL A Descriptive Study of Psychiatric Consultations in a Community Primary Care Center. Pirl WF, Beck BJ, Safren SA, Kim H Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality in kindreds with familial combined hyperlipidemia or familial hypertriglyceridemia. Kim H, Marcovina SM, Edwards KL, McKnight B, Bradley CM, McNeely MJ, Psaty BM, Motulsky AG, Austin MA Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality. H. Kim, SM. Marcovina, KL. Edwards, B. McKnight, CM. Bradley, MJ. McNeely, BM. Psaty, AG. Motulsky, MA. Austin Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Kim H, Gearing M, Mirra SS
