Helen Kim, PhD, MPH

Professor

[email protected]

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Center for Cerebrovascular Research

Biography

My research focuses on identifying risk factors that predispose younger individuals to stroke and cardiovascular disease. Currently, my group is studying the genetic epidemiology of hemorrhagic stroke and modifiers of outcome after hemorrhage or treatment in patients with brain vascular malformations. I collaborate closely with a multidisciplinary group of investigators at the UCSF Center for Cerebrovascular Research, Kaiser Permanente Division of Research in Oakland, Duke University, and the University of New Mexico. Several large case-cohort studies of brain arteriovenous malformations, subarachnoid hemorrhage, cerebral cavernous malformations, and hereditary hemorrhagic telangiectasia are underway. These vascular-related disorders, while distinct, share to some degree similar clinical symptoms and features. We are taking both candidate gene and genome-wide approaches to identify genetic factors associated with disease susceptibility and progression, including SNP and expression arrays, and next-gen sequencing. Additional research interests include investigating approaches for population stratification, multivariate phenotypes, admixture mapping, and gene-gene and gene-environment interactions.

Role

Faculty

Location

Zuckerberg San Francisco General Hospital

Category

Clinical

Research

Education

2019 - Diversity, Equity, and Inclusion Champion Training, University of California

PhD, 12/2003 - Epidemiology, University of Washington

Certificate, 12/2003 - Public Health Genetics, University of Washington

MPH, 05/1997 - Epidemiology, Emory University

Publications

Common and distinct circulating microRNAs in four neurovascular disorders.

Janne Koskimäki, Aditya Jhaveri, Abhinav Srinath, Akash Bindal, Diana Vera Cruz, Geetha Priyanka Yeradoddi, Rhonda Lightle, Justine Lee, Agnieszka Stadnik, Javed Iqbal, Roberto Alcazar-Felix, Stephanie Hage, Sharbel Romanos, Robert Shenkar, Jeffrey Loeb, Marie E. Faughnan, Shantel Weinsheimer, Helen Kim, Romuald Girard, Issam A. Awad

Biochemistry and Biophysics Reports

Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts

Akers AL, Albanese J, Alcazar-Felix RJ, Al-Shahi Salman R, Awad IA, Connolly ES, Danehy A, Flemming KD, Gordon E, Hage S, Kim H, Lanzino G, Lee CH, McCormick PC, Mabray MC, Marchuk DA, Smith E, Smith KM, Srivastava S, Taylor JM, Vadivelu S

Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study

Salman RAS, Adamczuk K, Parker RA, Weir CJ, Latini R, Kim H, White D, Evans H, Bergholtz J, Lee C, Casaus C

Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study

Abstract TP161: Machine Learning to Glean Characteristics of Quantitative Susceptibility Maps in Cerebral Cavernous Angiomas with Symptomatic Hemorrhage.

Serena Kinkade, Hui Li, Stephanie Hage, Janne Koskimaki, Agnieszka Stadnik, Justinee Lee, John Papaioannou, Kelly Flemming, Helen Kim, Michel Torbey, Judy Huang, Timothy Carroll, Romuald Girard, Maryellen Giger, Issam Awad

Abstract WP40: Common and Distinct Circulating MicroRNAs Across Four Neurovascular Disorders.

Janne Koskimaki, Aditya Jhaveri, Abhinav Srinath, Diana Vera Cruz, Geetha Priyanka Yerradoddi, Carolyn Bennett, Akash Bindal, Rhonda Lightle, Juhyon Hsu, Agnieszka Stadnik, Stephanie Hage, Roberto Alcazar-Felix, Javed Iqbal, Sharbel Romanos, Hanadi Almazroue, Jeffrey Loeb, Marie Faughnan, Shantel Weinsheimer, Helen Kim, Romuald Girard, Issam Awad

Brain and lung arteriovenous malformation rescreening practices for children and adults with hereditary hemorrhagic telangiectasia.

Beslow LA, Kim H, Hetts SW, Ratjen F, Clancy MS, Gossage JR, Faughnan ME

Orphanet journal of rare diseases

Somatic mutations in arteriovenous malformations in hereditary hemorrhagic telangiectasia support a bi-allelic two-hit mutation mechanism of pathogenesis.

DeBose-Scarlett E, Ressler AK, Gallione CJ, Sapisochin Cantis G, Friday C, Weinsheimer S, Schimmel K, Spiekerkoetter E, Kim H, Gossage JR, Faughnan ME, Marchuk DA

American journal of human genetics

Arterial Spin-Labeling MR Imaging in the Detection of Intracranial Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia.

Alyafaie A, Han W, Li Y, Vydro SA, Vella M, Truong TL, Park L, Langston D, Kim H, Conrad MB, Hetts SW

AJNR. American journal of neuroradiology

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.

Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA

Arteriosclerosis, thrombosis, and vascular biology

Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia.

Beslow LA, Vossough A, Kim H, Nelson J, Lawton MT, Pollak J, Lin DDM, Ratjen F, Hammill AM, Hetts SW, Gossage JR, Whitehead KJ, Faughnan ME, Krings T, Brain Vascular Malformation Consortium HHT Investigator Group

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia.

Beslow LA, Krings T, Kim H, Hetts SW, Lawton MT, Ratjen F, Whitehead KJ, Gossage JR, McCulloch CE, Clancy M, Bagheri N, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

Pediatric neurology

Current and Future Treatment Options for Cerebral Cavernous Malformations

Leslie Morrison, MD, Juan Gutierrez, MD, Cenk Ayata, MD, PhD, Miguel Lopez-Toledano, PhD, Enrique Carrazana, MD, Issam Awad, MD, Adrian L. Rabinowicz, MD, and Helen Kim, MPH, PhD

Stroke: Vascular and Interventional Neurology

Abstract TP6: Identification of Circulating Epigenetic Biomarkers for Seizure in Brain Arteriovenous Malformation by Methylome Profiling.

Peter Park, Jeffrey Nelson, Christine K Fox, Adam Numis, Nerissa Ko, Ethan Winkler, Charles McCulloch, Helen Kim, Shantel Weinsheimer

Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations.

Ayata C, Kim H, Morrison L, Liao JK, Gutierrez J, Lopez-Toledano M, Carrazana E, Rabinowicz AL, Awad IA

Neurology. Genetics

Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse.

Zahra Shabani, Joana Schuerger, Xiaonan Zhu, Chaoliang Tang, Li Ma, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Calvin Wang, Abinav Sekhar, Jeffrey Nelson, Helen Kim, Hua Su

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome.

Flemming KD, Kim H, Hage S, Mandrekar J, Kinkade S, Girard R, Torbey M, Huang J, Huston J, Shu Y, Lanzino G, Selwyn R, Hart B, Mabray M, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson R, Koenig JI, Carroll T, Hanley D, Awad I

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling.

Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee NA, Treine K, Ostapkovich N, Wang Y, Thompson RE, Koenig JI, Carroll T, Hanley DF, Awad IA

Reply to Eker et al. Comment on “Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704”.

Alexandra Kilian, Giuseppe A. Latino, Andrew J. White, Felix Ratjen, Jamie McDonald, Kevin J. Whitehead, James R. Gossage, Timo Krings, Michael T. Lawton, Helen Kim, Marie E. Faughnan, The Brain Vascular Malformation Consortium HHT Investigator Group

Journal of clinical medicine

Factors Associated with Unfavorable Clinical Presentations in Patients with Ruptured BrainArteriovenous Malformations.

Garcia JH, Carrete L, Rutledge WC, Raygor KP, Winkler EA, Pereira MP, Nelson J, Kim H, Cooke DL, Hetts SW, Lawton MT, Abla AA

World neurosurgery

Exploring effects of atmospheric conditions in hereditary hemorrhagic telangiectasia.

Yusuf HM, Rasheed A, Hetts S, Kim H, Loftus P, Conrad M

International forum of allergy & rhinology

An analysis of sex differences in pulmonary arteriovenous malformation presentation, complications and management in a large, multinational registry of patients with hereditary haemorrhagic telangiectasia.

Tuff-Gordon E, Faughnan ME, Kim H, Lawton MT, Vozoris NT, Brain Vascular Malformation Consortium HHT Investigator Group, Brain Vascular Malformation Consortium HHT Investigator Group

ERJ open research

A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI.

Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y

Frontiers in medicine

Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT.

Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME

Journal of clinical medicine

A comparison of incidental and symptomatic unruptured brain arteriovenous malformations in children.

Lu AY, Winkler EA, Garcia JH, Raygor KP, Fullerton HJ, Fox CK, Kim H, Auguste KI, Sun PP, Hetts SW, Lawton MT, Abla AA, Gupta N

Journal of neurosurgery. Pediatrics

Abstract 52: Prevalence Of Somatic Activating Kras Mutations In Pediatric And Adult Sporadic Brain Arteriovenous Malformations.

Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim

Abstract 53: Long-term Treatment Risk Of Hemorrhage In Unruptured Brain Arteriovenous Malformation Patients.

Helen Kim, Jeffrey Nelson, Rustam Al-Shahi Salman, Kelly Flemming, Christopher Hess, Steven W Hetts, Päivi Koroknay-Pál, Aki Laakso, Giuseppe S Lanzino, Michael Lawton, Charles McCulloch, Nicole Moayeri, Jay P Mohr, Michael Morgan, Marco Stefani, Jonathan Zaroff, Yuanli Zhao

Abstract TMP17: Polymorphisms In DNA Methylated Genes And Risk Of Intracranial Hemorrhage In Brain Arteriovenous Malformation Patients.

Thinzar Zaw, Shantel Weinsheimer, Jeffrey Nelson, Charles McCulloch, Jonathan Zaroff, Helen Kim

Abstract TP157: Interleukin Plasma Levels And Risk Of Hemorrhage In Pediatric Brain Arteriovenous Malformation Patients.

Shweta A Chawla, Shantel Weinsheimer, Jeffrey Nelson, Charles McCulloch, Adib Abla, Nalin Gupta, Daniel L Cooke, Steven Hetts, David Saloner, Yi Li, Christine K Fox, Heather J Fullerton, Helen Kim

Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation.

Weinsheimer S, Nelson J, Abla AA, Ko NU, Tsang C, Okoye O, Zabramski JM, Akers A, Zafar A, Mabray MC, Hart BL, Morrison L, McCulloch CE, Kim H, Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group *

Journal of the American Heart Association

Identifying racial disparities in hereditary hemorrhagic telangiectasia.

Yusuf H, Rasheed A, Kim H, Conrad MB, Hetts SW

Journal of neurointerventional surgery

Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size.

Ananiadis T, Faughnan ME, Clark D, Prabhudesai V, Kim H, Lawton MT, Vozoris NT, Brain Vascular Malformation Consortium HHT Investigator Group

Annals of the American Thoracic Society

Machine learning for predicting hemorrhage in pediatric patients with brain arteriovenous malformation.

Saggi S, Winkler EA, Ammanuel SG, Morshed RA, Garcia JH, Young JS, Semonche A, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Abla A, Lawton MT, Gupta N

Journal of neurosurgery. Pediatrics

A single-cell atlas of the normal and malformed human brain vasculature.

Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ

Science (New York, N.Y.)

Validation of the Ruptured Arteriovenous Malformation Grading Scale in a pediatric cohort.

Garcia JH, Rutledge C, Winkler EA, Carrete L, Morshed RA, Lu AY, Saggi S, Fox CK, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Lawton MT, Gupta N, Abla AA

Journal of neurosurgery. Pediatrics

Childhood stroke.

Sporns PB, Fullerton HJ, Lee S, Kim H, Lo WD, Mackay MT, Wildgruber M

Nature reviews. Disease primers

Endoluminal Biopsy for Molecular Profiling of Human Brain Vascular Malformations.

Winkler E, Wu D, Gil E, McCoy D, Narsinh K, Sun Z, Mueller K, Ross J, Kim H, Weinsheimer S, Berger M, Nowakowski T, Lim D, Abla A, Cooke D

Maximizing Brain Health After Hemorrhagic Stroke: Bugher Foundation Centers of Excellence.

Sheth KN, Anderson CD, Biffi A, Dlamini N, Falcone GJ, Fox CK, Fullerton HJ, Greenberg SM, Hemphill JC, Kim A, Kim H, Ko NU, Roland JL, Sansing LH, van Veluw SJ, Rosand J

Quantification metrics for telangiectasia using optical coherence tomography.

Cardinell JL, Ramjist JM, Chen C, Shi W, Nguyen NQ, Yeretsian T, Choi M, Chen D, Clark DS, Curtis A, Kim H, Faughnan ME, Yang VXD, Brain Vascular Malformation Consortium HHT Investigator Group

Scientific reports

Abstract 109: Biological Pathways Enriched For Genes Associated With Lesion Burden In Cerebral Cavernous Malformation.

Aditya Sriram, Shantel Weinsheimer, Jeffrey Nelson, Marc Mabray, Joseph M Zabramski, Amy Akers, Blaine Hart, Leslie Morrison, Charles E McCulloch, Helen Kim

12 Genetics and Vascular Biology of Brain Vascular Malformations.

Helen Kim, Ludmila Pawlikowska, Hua Su

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).

Romuald Girard, Yan Li, Agnieszka Stadnik, Robert Shenkar, Nicholas Hobson, Sharbel Romanos, Abhinav Srinath, Thomas Moore, Rhonda Lightle, Abdallah Shkoukani, Amy Akers, Timothy Carroll, Gregory A Christoforidis, James I Koenig, Cornelia Lee, Kristina Piedad, Steven M Greenberg, Helen Kim, Kelly D Flemming, Yuan Ji, Issam A Awad

Factors associated with seizures at initial presentation in pediatric patients with cerebral arteriovenous malformations.

Garcia JH, Winkler EA, Morshed RA, Lu A, Ammanuel SG, Saggi S, Wang EJ, Braunstein S, Fox CK, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Lawton MT, Abla AA, Gupta N

Journal of neurosurgery. Pediatrics

Seizure Incidence Rates in Children and Adults With Familial Cerebral Cavernous Malformations.

Fox CK, Nelson J, McCulloch CE, Weinsheimer S, Pawlikowska L, Hart B, Mabray MC, Zafar A, Morrison L, Zabramski JM, Akers A, Kim H

Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.

Kim H, Flemming KD, Nelson JA, Lui A, Majersik JJ, Cruz MD, Zabramski J, Trevizo O, Lanzino G, Zafar A, Torbey M, Mabray MC, Robinson M, Narvid J, Lupo J, Thompson RE, Hanley DF, McBee N, Treine K, Ostapkovich N, Stadnik A, Piedad K, Hobson N, Carroll T, Shkoukani A, Carrión-Penagos J, Mendoza-Puccini C, Koenig JI, Awad I

Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation.

Choksi F, Weinsheimer S, Nelson J, Pawlikowska L, Fox CK, Zafar A, Mabray MC, Zabramski J, Akers A, Hart BL, Morrison L, McCulloch CE, Kim H

Molecular genetics & genomic medicine

Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations.

Wetzel-Strong SE, Weinsheimer S, Nelson J, Pawlikowska L, Clark D, Starr MD, Liu Y, Kim H, Faughnan ME, Nixon AB, Marchuk DA

Orphanet journal of rare diseases

Presence of Vessel Wall Hyperintensity in Unruptured Arteriovenous Malformations on Vessel Wall Magnetic Resonance Imaging: Pilot Study of AVM Vessel Wall "Enhancement".

Eisenmenger LB, Junn JC, Cooke D, Hetts S, Zhu C, Johnson KM, Manunga JM, Saloner D, Hess C, Kim H

Frontiers in neuroscience

Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype.

Gao S, Nelson J, Weinsheimer S, Winkler EA, Rutledge C, Abla AA, Gupta N, Shieh JT, Cooke DL, Hetts SW, Tihan T, Hess CP, Ko N, Walcott BP, McCulloch CE, Lawton MT, Su H, Pawlikowska L, Kim H

Journal of neurosurgery

Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation.

Keränen S, Suutarinen S, Mallick R, Laakkonen JP, Guo D, Pawlikowska L, Jahromi BR, Rauramaa T, Ylä-Herttuala S, Marchuk D, Krings T, Koivisto T, Lawton M, Radovanovic I, Kim H, Faughnan ME, Frösen J

Acta neurochirurgica

Intermediate-grade brain arteriovenous malformations and the boundary of operability using the supplemented Spetzler-Martin grading system.

Catapano JS, Frisoli FA, Nguyen CL, Labib MA, Cole TS, Baranoski JF, Kim H, Spetzler RF, Lawton MT

Journal of neurosurgery

Review of treatment and therapeutic targets in brain arteriovenous malformation.

Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Spetzler-Martin Grade III Arteriovenous Malformations: A Multicenter Propensity-Adjusted Analysis of the Effects of Preoperative Embolization.

Catapano JS, Frisoli FA, Nguyen CL, Wilkinson DA, Majmundar N, Cole TS, Baranoski JF, Whiting AC, Kim H, Ducruet AF, Albuquerque FC, Cooke DL, Spetzler RF, Lawton MT

Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation.

Muster R, Ko N, Smith W, Su H, Dickey MA, Nelson J, McCulloch CE, Sneed PK, Clarke JL, Saloner DA, Eisenmenger L, Kim H, Cooke DL

BMJ neurology open

Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation.

Rachel Muster, Nerissa Ko, Wade Smith, Hua Su, Melissa A Dickey, Jeffrey Nelson, Charles E McCulloch, Patricia K Sneed, Jennifer L Clarke, David A Saloner, Laura Eisenmenger, Helen Kim, Daniel L Cooke

BMJ neurology open

Maternal and Fetal Outcomes in Women with Brain Arteriovenous Malformation Rupture during Pregnancy.

Yan KL, Ko NU, Hetts SW, Weinsheimer S, Abla AA, Lawton MT, Kim H

Cerebrovascular diseases (Basel, Switzerland)

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).

Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IA

Systemic and CNS manifestations of inherited cerebrovascular malformations.

Hart BL, Mabray MC, Morrison L, Whitehead KJ, Kim H

Clinical imaging

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O, Gentric JC, Shotar E, Eugène F, Desal H, Winsvold BS, Børte S, Johnsen MB, Brumpton BM, Sandvei MS, Willer CJ, Hveem K, Zwart JA, Verschuren WMM, Friedrich CM, Hirsch S, Schilling S, Dauvillier J, Martin O, HUNT All-In Stroke, China Kadoorie Biobank Collaborative Group, BioBank Japan Project Consortium, ICAN Study Group, CADISP Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, International Stroke Genetics Consortium (ISGC), Jones GT, Bown MJ, Ko NU, Kim H, Coleman JRI, Breen G, Zaroff JG, Klijn CJM, Malik R, Dichgans M, Sargurupremraj M, Tatlisumak T, Amouyel P, Debette S, Rinkel GJE, Worrall BB, Pera J, Slowik A, Gaál-Paavola EI, Niemelä M, Jääskeläinen JE, von Und Zu Fraunberg M, Lindgren A, Broderick JP, Werring DJ, Woo D, Redon R, Bijlenga P, Kamatani Y, Veldink JH, Ruigrok YM

Nature genetics

Interrater Reliability in the Measurement of Flow Characteristics on Color-Coded Quantitative DSA of Brain AVMs.

Narsinh KH, Mueller K, Nelson J, Massachi J, Murph DC, Copelan AZ, Hetts SW, Halbach VV, Higashida RT, Abla AA, Amans MR, Dowd CF, Kim H, Cooke DL

AJNR. American journal of neuroradiology

Brain Arteriovenous Malformation Recurrence After Apparent Microsurgical Cure: Increased Risk in Children Who Present With Arteriovenous Malformation Rupture.

Copelan A, Drocton G, Caton MT, Smith ER, Cooke DL, Nelson J, Abla AA, Fox C, Amans MR, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Kim H, Fullerton HJ, Gupta N, Hetts SW, UCSF Center For Cerebrovascular Research and UCSF Pediatric Brain Center

Genotype-Phenotype Correlations in Children with HHT.

Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, the Brain Vascular Malformation Consortium HHT Investigator Group

Journal of clinical medicine

Medical management with interventional therapy versus medical management alone for unruptured brain arteriovenous malformations (ARUBA): final follow-up of a multicentre, non-blinded, randomised controlled trial.

Mohr JP, Overbey JR, Hartmann A, Kummer RV, Al-Shahi Salman R, Kim H, van der Worp HB, Parides MK, Stefani MA, Houdart E, Libman R, Pile-Spellman J, Harkness K, Cordonnier C, Moquete E, Biondi A, Klijn CJM, Stapf C, Moskowitz AJ, ARUBA co-investigators

The Lancet. Neurology

Concurrent Presentation of Brain Arteriovenous Malformation, Peripheral Arteriovenous Malformation, and Cerebellar Astrocytoma: Case report.

Ayushi Gautam, Zhengda Sun, Ethan Winkler, Hua Su, Tim McCalmont, Helen Kim, Tarik Tihan, William Y. Hoffman, Chris F. Dowd, Ilona J. Frieden, Daniel L. Cooke

Interdisciplinary Neurosurgery

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.

Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA

Nature communications

Bringing high-grade arteriovenous malformations under control: clinical outcomes following multimodality treatment in children.

Winkler EA, Lu A, Morshed RA, Yue JK, Rutledge WC, Burkhardt JK, Patel AB, Ammanuel SG, Braunstein S, Fox CK, Fullerton HJ, Kim H, Cooke D, Hetts SW, Lawton MT, Abla AA, Gupta N

Journal of neurosurgery. Pediatrics

High-Flow Vascular Malformations in Children.

Morshed RA, Winkler EA, Kim H, Braunstein S, Cooke DL, Hetts SW, Abla AA, Fullerton HJ, Gupta N

Seminars in neurology

Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report.

Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL

Interdisciplinary neurosurgery : Advanced techniques and case management

Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity.

Choquet H, Kim H

Methods in molecular biology (Clifton, N.J.)

Angiopoietin-2 predicts morbidity in adults with Fontan physiology.

Shirali AS, Lluri G, Guihard PJ, Conrad MB, Kim H, Pawlikowska L, Boström KI, Iruela-Arispe ML, Aboulhosn JA

Scientific reports

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML

Science Translational Medicine

Cost determinants in management of brain arteriovenous malformations.

Rutledge C, Nelson J, Lu A, Nisson P, Jonzzon S, Winkler EA, Cooke D, Abla AA, Lawton MT, Kim H

Acta neurochirurgica

Effect of Simvastatin on Permeability in Cerebral Cavernous Malformation Type 1 Patients: Results from a Pilot Small Randomized Controlled Clinical Trial.

Mabray MC, Caprihan A, Nelson J, McCulloch CE, Zafar A, Kim H, Hart BL, Morrison L

Translational stroke research

The effect of preoperative embolization and flow dynamics on resection of brain arteriovenous malformations.

Donzelli GF, Nelson J, McCoy D, McCulloch CE, Hetts SW, Amans MR, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Kim H, Cooke DL

Journal of neurosurgery

Familial Cerebral Cavernous Malformations.

Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L

Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).

Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Koskimäki J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IA

A novel proposed grading system for cerebellar arteriovenous malformations.

Nisson PL, Fard SA, Walter CM, Johnstone CM, Mooney MA, Tayebi Meybodi A, Lang M, Kim H, Jahnke H, Roe DJ, Dumont TM, Lemole GM, Spetzler RF, Lawton MT

Journal of neurosurgery

Abstract TP578: Comparison of Demographic, Clinical, and Angiographic Characteristics Between Pediatric and Adult HHT Patients With Brain AVMs.

Ayushi Gautam, Jeffrey Nelson, Helen Kim, Steven Hetts

Assessing the Hereditary Hemorrhagic Telangiectasia Algorithms in a Community-Based Patient Population.

Saparia T, Faughnan ME, Schneider JL, Almers LM, Chow N, Grosse SD, Kim H, Zaroff JG

The Permanente journal

Does eloquence subtype influence outcome following arteriovenous malformation surgery?

Mascitelli JR, Yoon S, Cole TS, Kim H, Lawton MT

Journal of neurosurgery

The Unique Features and Outcomes of Microsurgically Resected Cerebellar Arteriovenous Malformations.

Nisson PL, Fard SA, Meybodi AT, Mooney MA, Kim H, Jahnke H, Walter CM, Dumont TM, Lemole GM, Lawton MT, Spetzler RF

World neurosurgery

Evaluation of Angioarchitectural Features of Unruptured Brain Arteriovenous Malformation by Susceptibility Weighted Imaging.

Wu CX, Ma L, Chen XZ, Chen XL, Chen Y, Zhao YL, Hess C, Kim H, Jin HW, Ma J

World neurosurgery

Frequency and characteristics associated with inherited thrombophilia in patients with intracranial dural arteriovenous fistula.

LaHue SC, Kim H, Pawlikowska L, Nelson J, Cooke DL, Hetts SW, Singh V

Journal of neurosurgery

Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia.

Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Kim H, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

Molecular genetics & genomic medicine

Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study.

Alexander MD, Hippe DS, Cooke DL, Hallam DK, Hetts SW, Kim H, Lawton MT, Sekhar LN, Kim LJ, Ghodke BV

Abstract WP427: Health-related Quality of Life Measures in Familial Cerebral Cavernous Malformation Patients.

Keva C DeKay, Diana Guo, Kimberly Yan, Jeffrey Nelson, Charles E McCulloch, Amy Akers, Mary Rose Bartlett, Blaine Hart, Yashar Kalani, Mary Harrigan, Joseph Zabramski, Leslie Morrison, Helen Kim

Predictors of intracranial hemorrhage volume and distribution in brain arteriovenous malformation.

Yu JF, Nicholson AD, Nelson J, Alexander MD, Tse SH, Hetts SW, Hemphill JC, Kim H, Cooke DL

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Reductions in brain pericytes are associated with arteriovenous malformation vascular instability.

Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT

Journal of neurosurgery

Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study.

Meybodi AT, Kim H, Nelson J, Hetts SW, Krings T, terBrugge KG, Faughnan ME, Lawton MT, Brain Vascular Malformation Consortium HHT
Investigator Group

Microsurgical resection of brain arteriovenous malformations in the elderly: outcomes analysis and risk stratification.

Burkhardt JK, Lasker GF, Winkler EA, Kim H, Lawton MT

Journal of neurosurgery

Early Hemodynamic Changes Based on Initial Color-Coding Angiography as a Predictor for Developing Subsequent Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

Burkhardt JK, Chen X, Winkler EA, Weiss M, Yue JK, Cooke DL, Kim H, Lawton MT

World neurosurgery

Pial Artery Supply as an Anatomic Risk Factor for Ischemic Stroke in the Treatment of Intracranial Dural Arteriovenous Fistulas.

Hetts SW, Yen A, Cooke DL, Nelson J, Jolivalt P, Banaga J, Amans MR, Dowd CF, Higashida RT, Lawton MT, Kim H, Halbach VV

AJNR. American journal of neuroradiology

Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.

Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z

Translational stroke research

Functional impairments for outcomes in a randomized trial of unruptured brain AVMs.

Mohr JP, Overbey JR, von Kummer R, Stefani MA, Libman R, Stapf C, Parides MK, Pile-Spellman J, Moquete E, Moy CS, Vicaut E, Moskowitz AJ, Harkness K, Cordonnier C, Biondi A, Houdart E, Berkefeld J, Klijn CJM, Barreau X, Kim H, Hartmann A, International ARUBA Investigators

Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages.

Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H

Synopsis of guidelines for the clinical management of cerebral cavernous malformations: Consensus recommendations based on systematic literature review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.

Amy Akers, Rustam Al-Shahi Salman, Issam A. Awad, Kristen Dahlem, Kelly Flemming, Blaine Hart, Helen Kim, Ignacio Jusue-Torres, Douglas Kondziolka, Cornelia Lee, Leslie Morrison, Daniele Rigamonti, Tania Rebeiz, Elisabeth Tournier-Lasserve, Darrel Waggoner, Kevin Whitehead

Prevalence and predictors of anemia in hereditary hemorrhagic telangiectasia.

Kasthuri RS, Montifar M, Nelson J, Kim H, Lawton MT, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

American journal of hematology

Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations.

Zou X, Hart BL, Mabray M, Bartlett MR, Bian W, Nelson J, Morrison LA, McCulloch CE, Hess CP, Lupo JM, Kim H

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.

Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K

Delayed Venous Drainage in Ruptured Arteriovenous Malformations Based on Quantitative Color-Coded Digital Subtraction Angiography.

Burkhardt JK, Chen X, Winkler EA, Cooke DL, Kim H, Lawton MT

World neurosurgery

Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition.

Strickland CD, Eberhardt SC, Bartlett MR, Nelson J, Kim H, Morrison LA, Hart BL

Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation.

Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y

Cerebrovascular diseases (Basel, Switzerland)

Abstract 120: Radiocarbon Birth Dating of Cerebral Arteriovenous Malformations.

Daniel L Cooke, Meike Halberkann, Christian Matzenauer, Helen Kim, Michael Lawton, Kerim Beseoglu, Rita Dreier, Bruce Buchholz, R. Loch Macdonald, Nima Etminan

Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study.

Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, Lafer B

International journal of geriatric psychiatry

Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages.

Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T

Clinical neuropathology

Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection.

Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Clinical Impairment in Patients Followed with or without Interventional Therapy in a Randomized Trial of Unruptured Brain AVMs (ARUBA) (S7.007).

J. Mohr, Jessica Overbey, Christian Stapf, Andreas Hartmann, Marco Stefani, Michael Parides, Ellen Moquete, Claudia Moy, E Vicaut, Alan Moskowitz, R. Al-Shahi Salman, E. Houdart, Charlotte Cordonnier, Ruediger von Kummer, Alessandra Biondi, J. Berkefeld, C. Klijn, Kristy Harkness, Richard Libman, X Barreau, Helen Kim

Abstract 53: Variation in DNA Mismatch Repair Genes Nominally Associated With Severity of Cerebral Cavernous Malformation Type 1.

Hélène Choquet, Ludmila Pawlikowska, Jeffrey Nelson, Charles E. McCulloch, Amy Akers, Yasir Khan, Blaine Hart, Leslie Morrison, Helen Kim

Abstract WP436: Comparing Risk of Stroke and Death in Treated and Untreated Patients With Unruptured Brain Arteriovenous Malformations (BAVM).

Helen Kim, Jeffrey Nelson, Charles E McCulloch, Michael T Lawton, Jay P Mohr, Christian Stapf, Rustam Al-Shahi Salman

Genome-wide association study of sporadic brain arteriovenous malformations.

Weinsheimer S, Bendjilali N, Nelson J, Guo DE, Zaroff JG, Sidney S, McCulloch CE, Al-Shahi Salman R, Berg JN, Koeleman BP, Simon M, Bostroem A, Fontanella M, Sturiale CL, Pola R, Puca A, Lawton MT, Young WL, Pawlikowska L, Klijn CJ, Kim H, GEN-AVM Consortium

Journal of neurology, neurosurgery, and psychiatry

Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.

Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF

Free radical biology & medicine

107 The Role of Oxidative Stress in Cerebral Cavernous Malformation (CCM) Pathogenesis: From Disease Mechanisms toward Therapeutic Approaches.

Eliana Trapani, Saverio Marchi, Helene Choquet, Luca Goitre, Andrea Moglia, Cinzia Antognelli, Simona Delle Monache, Lorenza Trabalzini, Helen Kim, Paolo Pinton, Saverio Francesco Retta

Free Radical Biology and Medicine

Harms associated with single unit perioperative transfusion: retrospective population based analysis.

Whitlock EL, Kim H, Auerbach AD

BMJ (Clinical research ed.)

Brain arteriovenous malformations.

Lawton MT, Rutledge WC, Kim H, Stapf C, Whitehead KJ, Li DY, Krings T, terBrugge K, Kondziolka D, Morgan MK, Moon K, Spetzler RF

Nature reviews. Disease primers

Silent arteriovenous malformation hemorrhage and the recognition of "unruptured" arteriovenous malformation patients who benefit from surgical intervention.

Abla AA, Nelson J, Kim H, Hess CP, Tihan T, Lawton MT

Genetics of cerebral cavernous malformations: current status and future prospects.

Choquet H, Pawlikowska L, Lawton MT, Kim H

Journal of neurosurgical sciences

Surgical treatment of cerebral cavernous malformations.

Davies JM, Kim H, Lawton MT

Journal of neurosurgical sciences

Hemorrhage rates from brain arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia.

Kim H, Nelson J, Krings T, terBrugge KG, McCulloch CE, Lawton MT, Young WL, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations.

Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Young WL, Kim H, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

American journal of medical genetics. Part A

Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis.

Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL

Journal of neurointerventional surgery

Current surgical results with low-grade brain arteriovenous malformations.

Potts MB, Lau D, Abla AA, Kim H, Young WL, Lawton MT, UCSF Brain AVM Study Project

Journal of neurosurgery

Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage.

Alexander MD, Cooke DL, Nelson J, Guo DE, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H, Hetts SW

AJNR. American journal of neuroradiology

Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations.

Krings T, Kim H, Power S, Nelson J, Faughnan ME, Young WL, terBrugge KG, Brain Vascular Malformation Consortium HHT Investigator Group

AJNR. American journal of neuroradiology

Increased number of white matter lesions in patients with familial cerebral cavernous malformations.

Golden MJ, Morrison LA, Kim H, Hart BL

AJNR. American journal of neuroradiology

Brainstem arteriovenous malformations: anatomical subtypes, assessment of "occlusion in situ" technique, and microsurgical results.

Han SJ, Englot DJ, Kim H, Lawton MT

Journal of neurosurgery

Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients.

Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, Stapleton C, Walcott BP, Ogilvy CS, Spetzler RF, Lawton MT

Severity score for hereditary hemorrhagic telangiectasia.

Latino GA, Kim H, Nelson J, Pawlikowska L, Young W, Faughnan ME, Brain Vascular Malformation Consortium HHT Investigator Group

Orphanet journal of rare diseases

Viewpoints on the ARUBA trial.

Mohr JP, Hartmann A, Kim H, Pile-Spellman J, Stapf C

AJNR. American journal of neuroradiology

Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity.

Choquet H, Pawlikowska L, Nelson J, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H, Brain Vascular Malformation Consortium (BVMC) Study

Cerebrovascular diseases (Basel, Switzerland)

A treatment paradigm for high-grade brain arteriovenous malformations: volume-staged radiosurgical downgrading followed by microsurgical resection.

Abla AA, Rutledge WC, Seymour ZA, Guo D, Kim H, Gupta N, Sneed PK, Barani IJ, Larson D, McDermott MW, Lawton MT

Journal of neurosurgery

The natural history of AVM hemorrhage in the posterior fossa: comparison of hematoma volumes and neurological outcomes in patients with ruptured infra- and supratentorial AVMs.

Abla AA, Nelson J, Rutledge WC, Young WL, Kim H, Lawton MT

Neurosurgical focus

Treatment and outcomes of ARUBA-eligible patients with unruptured brain arteriovenous malformations at a single institution.

Rutledge WC, Abla AA, Nelson J, Halbach VV, Kim H, Lawton MT

Neurosurgical focus

Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain.

Kremer PH, Koeleman BP, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, Zaroff JG, Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA, Veldink JH, Kim H, Klijn CJ

Journal of neurology, neurosurgery, and psychiatry

Untreated brain arteriovenous malformation: patient-level meta-analysis of hemorrhage predictors.

Kim H, Al-Shahi Salman R, McCulloch CE, Stapf C, Young WL, MARS Coinvestigators

Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations.

Rutledge WC, Ko NU, Lawton MT, Kim H

Translational stroke research

Endoglin deficiency impairs stroke recovery.

Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H

Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms.

Bendjilali N, Nelson J, Weinsheimer S, Sidney S, Zaroff JG, Hetts SW, Segal M, Pawlikowska L, McCulloch CE, Young WL, Kim H

Journal of neurology, neurosurgery, and psychiatry

Influence of patient age on angioarchitecture of brain arteriovenous malformations.

Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H

AJNR. American journal of neuroradiology

Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation.

Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H

Neuroimmunology and neuroinflammation

Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation.

Choquet H, Nelson J, Pawlikowska L, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H

Cerebrovascular diseases (Basel, Switzerland)

A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformation.

Bendjilali N, Kim H, Weinsheimer S, Guo DE, Kwok PY, Zaroff JG, Sidney S, Lawton MT, McCulloch CE, Koeleman BP, Klijn CJ, Young WL, Pawlikowska L

Brain Vascular Malformation Consortium: Overview, Progress and Future Directions.

Akers AL, Ball KL, Clancy M, Comi AM, Faughnan ME, Gopal-Srivastava R, Jacobs TP, Kim H, Krischer J, Marchuk DA, McCulloch CE, Morrison L, Moses M, Moy CS, Pawlikowska L, Young WL

The Journal of rare disorders

Abstract 188: Clinical Factors Associated with Lesion Count in Familial Cerebral Cavernous Malformation Type 1 Patients with the Common Hispanic Mutation.

He´le`ne Choquet, Jeff Nelson, Ludmila Pawlikowska, Amy Akers, Beth Baca, Yasir Khan, Blaine Hart, Leslie Morrison, Helen Kim

Abstract TMP30: Genetic Variants on 9p21.3 are Associated with Brain Arteriovenous Malformations with Associated Arterial Aneurysms.

Nasrine Bendjilali, Jeffrey Nelson, Shantel Weinsheimer, Stephen Sidney, Jonathan G Zaroff, Mark Segal, Ludmila Pawlikowska, Charles E McCulloch, William L Young, Helen Kim

Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhage.

Zaroff JG, Leong J, Kim H, Young WL, Cullen SP, Rao VA, Sorel M, Quesenberry CP, Sidney S

Neurocritical care

Cerebellar arteriovenous malformations: anatomic subtypes, surgical results, and increased predictive accuracy of the supplementary grading system.

Rodríguez-Hernández A, Kim H, Pourmohamad T, Young WL, Lawton MT, University of California, San Francisco Arteriovenous Malformation Study Project

Polymorphisms in ACVRL1 and endoglin genes are not associated with sporadic and HHT-related brain AVMs in Dutch patients.

Boshuisen K, Brundel M, de Kovel CGF, Letteboer TG, Rinkel GJE, Westermann CJJ, Kim H, Pawlikowska L, Koeleman BPC, Klijn CJM

Translational stroke research

Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.

Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: gene-phenotype correlations.

Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, Terbrugge KG, White RI

American journal of medical genetics. Part A

G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation.

Weinsheimer S, Brettman AD, Pawlikowska L, Wu DC, Mancuso MR, Kuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE, Young WL, Kuo C, Kim H

Translational stroke research

Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery.

Kim H, Pourmohamad T, Westbroek EM, McCulloch CE, Lawton MT, Young WL

Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.

Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ

Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation.

Westbroek EM, Pawlikowska L, Lawton MT, McCulloch CE, Young WL, Kim H

Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.

Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim, Yongmei Chen, Charles E. McCulloch, Nicholas M. Barbaro, Michael T. Lawton, William L. Young, Gregory J. Bix

The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.

Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA, DOGMATIC Study Investigators

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling.

Degos V, Apfel CC, Sanchez P, Colonne C, Renuit I, Clarençon F, Nouet A, Boch AL, Pourmohamad T, Kim H, Gourraud PA, Young WL, Puybasset L

Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture.

Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL, University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project

Abstract 3187: Inflammatory Cell Infiltration Correlates with Hemosiderin Deposition (Intra-lesion Hemorrhage) in Surgical Excised Unruptured Human Brain Arteriovenous Malformations.

Yi Guo, Hua Su, Helen Kim, Michael T. Lawton, Andrew W. Bollen, William L. Young

Abstract 3242: Brain-derived Neurotrophic Factor Val66Met Polymorphism is Associated with Worsening of Functional Outcome in Patients Undergoing Resection of Unruptured Brain Arteriovenous Malformations.

Erick M Westbroek, Ludmila Pawlikowska, Michael T Lawton, Charles E McCulloch, William L Young, Helen Kim

Classification schemes for arteriovenous malformations.

Davies JM, Kim H, Young WL, Lawton MT

Neurosurgery clinics of North America

Gene expression profiling of blood in brain arteriovenous malformation patients.

Weinsheimer SM, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL

Translational stroke research

Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagic telangiectasia: quantitative assessment.

Bharatha A, Faughnan ME, Kim H, Pourmohamad T, Krings T, Bayrak-Toydemir P, Pawlikowska L, McCulloch CE, Lawton MT, Dowd CF, Young WL, Terbrugge KG

Three Authors Reply.

Helen Kim, Charles E. McCulloch, William L. Young

American journal of epidemiology

Arteriovenous malformation in the adult mouse brain resembling the human disease.

Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL

Annals of neurology

Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations.

Mikhak B, Weinsheimer S, Pawlikowska L, Poon A, Kwok PY, Lawton MT, Chen Y, Zaroff JG, Sidney S, McCulloch CE, Young WL, Kim H

Cerebrovascular diseases (Basel, Switzerland)

12 Genetics and Vascular Biology of Brain Vascular Malformations.

Helen Kim, Ludmila Pawlikowska, William L. Young

Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm.

Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL

Acta neurochirurgica. Supplement

VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice.

Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL

Translational stroke research

Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture.

Kim H, McCulloch CE, Johnston SC, Lawton MT, Sidney S, Young WL

American journal of epidemiology

A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery.

Lawton MT, Kim H, McCulloch CE, Mikhak B, Young WL

Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.

Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL

The American journal of pathology

Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population.

Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol AS, Zaroff JG, Young WL

Biology of vascular malformations of the brain.

Leblanc GG, Golanov E, Awad IA, Young WL, Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators

EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations.

Weinsheimer S, Kim H, Pawlikowska L, Chen Y, Lawton MT, Sidney S, Kwok PY, McCulloch CE, Young WL

Circulation. Cardiovascular genetics

Race\ethnicity and outcome after traumatic brain injury at a single, diverse center.

Sorani MD, Lee M, Kim H, Meeker M, Manley GT

The Journal of trauma

Soluble endoglin modulates aberrant cerebral vascular remodeling.

Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL

Annals of neurology

Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity.

Sanchez-Mejia RO, McDermott MW, Tan J, Kim H, Young WL, Lawton MT

Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.

Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok PY, Young WL

Cerebrovascular diseases (Basel, Switzerland)

Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development.

Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL

Population stratification in a case-control study of brain arteriovenous malformation in Latinos.

Kim H, Hysi PG, Pawlikowska L, Choudhry S, González Burchard E, Kwok PY, Sidney S, McCulloch CE, Young WL

Neuroepidemiology

Genome-wide linkage scan for the metabolic syndrome: the GENNID study.

Edwards KL, Hutter CM, Wan JY, Kim H, Monks SA

Obesity (Silver Spring, Md.)

Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage.

Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL

Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance.

Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL

Cerebrovascular diseases (Basel, Switzerland)

Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations.

Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL

Acta neurochirurgica. Supplement

Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment.

Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL

Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients.

Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL, UCSF BAVM Study Project

Arteriovenous malformation.

Young WL, Kwok PY, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk DA

Journal of neurosurgery

Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: the Collaborative Study on the Genetics of Alcoholism.

Kim H, Hutter CM, Monks SA, Edwards KL

The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension.

Dreisbach AW, Japa S, Sigel A, Parenti MB, Hess AE, Srinouanprachanh SL, Rettie AE, Kim H, Farin FM, Hamm LL, Lertora JJ

American journal of hypertension

Family history as a risk factor for stroke in young women.

Kim H, Friedlander Y, Longstreth WT, Edwards KL, Schwartz SM, Siscovick DS

American journal of preventive medicine

Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape.

Meyer-Olson D, Shoukry NH, Brady KW, Kim H, Olson DP, Hartman K, Shintani AK, Walker CM, Kalams SA

The Journal of experimental medicine

Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study.

Goode EL, Badzioch MD, Kim H, Gagnon F, Rozek LS, Edwards KL, Jarvik GP, Framingham Heart Study

Family history of diabetes as a potential public health tool.

Harrison TA, Hindorff LA, Kim H, Wines RC, Bowen DJ, McGrath BB, Edwards KL

American journal of preventive medicine

A Descriptive Study of Psychiatric Consultations in a Community Primary Care Center.

Pirl WF, Beck BJ, Safren SA, Kim H

Primary care companion to the Journal of clinical psychiatry

Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality in kindreds with familial combined hyperlipidemia or familial hypertriglyceridemia.

Kim H, Marcovina SM, Edwards KL, McKnight B, Bradley CM, McNeely MJ, Psaty BM, Motulsky AG, Austin MA

Clinical genetics

Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality.

H. Kim, SM. Marcovina, KL. Edwards, B. McKnight, CM. Bradley, MJ. McNeely, BM. Psaty, AG. Motulsky, MA. Austin

Atherosclerosis

Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies.

Kim H, Gearing M, Mirra SS