Overview Brain arteriovenous malformations (bAVMs) are a leading cause of hemorrhagic stroke in younger people. Surgery and other invasive treatments pose risks that may outweigh its benefits, especially for patients who are diagnosed with an unruptured bAVM, which has not yet caused bleeding in the brain. Doctors still find it challenging as to whether or not they should treat an unruptured bAVM, carefully monitor their patients, or only treat those at higher risk of hemorrhage. The goal of this project was to conduct a large, multi-center study to estimate the long-term risk of hemorrhage in untreated and treated patients diagnosed with unruptured bAVMs to better inform clinical care and treatment decisions. For this project, we collected data from unruptured bAVM patients seen at 5 sites in the U.S. and 5 sites outside the U.S. (U.K., Finland, Australia, China, and Brazil). We collected clinical, imaging, treatment, and outcome data from medical records or surveys at diagnosis and during follow-up. Individual-level data were pooled together for analysis from 3,262 unruptured bAVM patients, with 12,044 person-years of follow-up time while untreated and 20,035 person-years of follow-up time after treatment. Affiliated Lab Center for Cerebrovascular Research Principal investigator UCSF Helen Kim, MPH, PhD Professor in Residence Seeking collaborators Our project is looking for individuals to join our team. Get in touch if you’d like to learn more. Email Us Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
Center for Cerebrovascular Research Epigenetic signatures and association with hemorrhage and high risk features in brain arteriovenous malformation
Center for Cerebrovascular Research Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Center for Cerebrovascular Research Predictors of growth, recurrence, and high-risk features in pediatric brain arteriovenous malformation (project 1)
Center for Cerebrovascular Research IL-6 trans-signaling increases risk for perioperative neurocognitive disorders in aging and neurodegenerative diseases
Center for Cerebrovascular Research Reduction of brain AVM severity through inhibition of pathogenic angiogenesis
Center for Cerebrovascular Research Investigating disparities and barriers in access to research and care for patients with Hereditary Hemorrhagic Telangiectasia (HHT)
Center for Cerebrovascular Research Cellular loci involved in the pathogenesis of brain arteriovenous malformations
Center for Cerebrovascular Research Modifiers of disease severity and progression in familial cerebral cavernous malformation (BVMC 6201)
Center for Cerebrovascular Research Cerebral hemorrhage risk in hereditary hemorrhagic telangiectasia (BVMC 6203)
Center for Cerebrovascular Research Detection of somatic mutations in cerebral cavernous malformation patients using non-invasive cell-free DNA screening
Center for Cerebrovascular Research Integrated longitudinal studies to identify biomarkers and therapeutic strategies for Sturge-Weber Syndrome (BVMC 6211)