Biography Judith Hellman, M.D. is the William L. Young, M.D. Endowed Professor and Vice Chair for Research in the Department of Anesthesia and Perioperative Care at the University of California, San Francisco (UCSF). She is an ICU physician-scientist doing basic-translational research on sepsis and inflammation. She did residencies in Internal Medicine and Anesthesiology, an ICU fellowship, and a post-doctoral T32-funded research fellowship in sepsis. She was on faculty at Harvard Medical School/Massachusetts General Hospital between 1997-2008 and joined the UCSF faculty in 2008. Dr. Hellman’s lab studies immunologic mechanisms and immunomodulation in sepsis and injury, focusing on innate immunity, organ injury and endothelial dysfunction, and on the immune modulating effects of components of Cannabis, of a class of lipids known as vanilloids, and of the endocannabinoid and endovanilloid systems. Role Faculty Location UCSF at Parnassus Category Clinical Research Education 2018 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaM.D., 1989 - School of Medicine, Columbia University Publications Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation. Gregory DJ, Han F, Li P, Gritsenko MA, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS Neonatal Cannabidiol Exposure Impairs Spatial Memory and Disrupts Neuronal Dendritic Morphology in Young Adult Rats. Wadhwa M, Chinn GA, Sasaki Russell JM, Hellman J, Sall JW Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo. Bokoch MP, Xu F, Govindaraju K, Lloyd E, Tsutsui K, Kothari RP, Adelmann D, Joffre J, Hellman J Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s. Roy P, Maturano J, Hasdemir H, Lopez A, Xu F, Hellman J, Tajkhorshid E, Sarlah D, Das A Surviving Sepsis Campaign Research Priorities 2023. De Backer D, Deutschman CS, Hellman J, Myatra SN, Ostermann M, Prescott HC, Talmor D, Antonelli M, Pontes Azevedo LC, Bauer SR, Kissoon N, Loeches IM, Nunnally M, Tissieres P, Vieillard-Baron A, Coopersmith CM, Surviving Sepsis Campaign Research Committee Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS Abstract 14589: Impairment of Endothelial Function by Chronic Cannabis Use: An Interim Analysis of the CANDIDE Study. Leila Mohammadi, Mina Navabzadeh, Daniel D Han, Emma Reagan, Jordan Naughton, Lylybell Zhou, Rahul Almeida, Kathryn Park, Keith Uyemura, Natasha Goyal, Poonam Rao, Judith Hellman, Jing Cheng, Gregory M Marcus, Matthew L Springer The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats. Soni I, Chinn GA, Halifax JC, Lynch KL, Sall JW Chapter 2 The endocannabinoid system, immunomodulation, and LPS-induced inflammation. Elliot Lloyd, Nina Nguyen, Judith Hellman Reply to Khatun <i>et al.</i> Joffre J, Matthay MA, Hellman J Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive. Roy P, Dennis DG, Eschbach MD, Anand SD, Xu F, Maturano J, Hellman J, Sarlah D, Das A A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery. Barreto Chang OL, Whitlock EL, Arias AD, Tsoy E, Allen IE, Hellman J, Bickler PE, Miller B, Possin KL A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery. Liao WI, Maruyama D, Kianian F, Tat C, Tian X, Hellman J, Dodd-O JM, Prakash A N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J Triggering toxicity: How antibiotics can enhance the release of outer membrane vesicles from Escherichia coli during sepsis. Lea V. Michel, Anna Konovalova, Judith Hellman, Thomas Gaborski Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122]. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC Abstract 11496: Increased Pulmonary Microvascular Endothelial Permeability by E-Cigarette Aerosol: The Pathway from Lung to Peripheral Blood Vessels. Leila Mohammadi, Daniel D Han, Xiaohui Fang, Fengyun Xu, Ronak Derakhshandeh, Judith Hellman, Jeffrey Gotts, Matthew L Springer Abstract 9929: Inhibition of Receptor for Advanced Glycation End Products (RAGE) Reduces E-Cigarette-Induced Increase in Endothelial Permeability. Daniel D Han, Fengyun Xu, Ronak Derakhshandeh, Abel Huang, Adam Whitlatch, Rachel J Keith, Naomi Hamburg, Peter Ganz, Judith Hellman, Suzaynn Schick, Matthew L Springer, Leila Mohammadi Isolation of Primary Mouse Lung Endothelial Cells. Wong E, Nguyen N, Hellman J Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Martin-Loeches I, Nunnally ME, Hellman J, Lat I, Martin GS, Jog S, Kesecioglu J, De Backer D, Coopersmith CM ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Joffre J, Hellman J The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness. Coopersmith CM, Antonelli M, Bauer SR, Deutschman CS, Evans LE, Ferrer R, Hellman J, Jog S, Kesecioglu J, Kissoon N, Martin-Loeches I, Nunnally ME, Prescott HC, Rhodes A, Talmor D, Tissieres P, De Backer D Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. Michel LV, Gallardo L, Konovalova A, Bauer M, Jackson N, Zavorin M, McNamara C, Pierce J, Cheng S, Snyder E, Hellman J, Pichichero ME Endothelial Responses in Sepsis. Joffre J, Hellman J, Ince C, Ait-Oufella H The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities. Deutschman CS, Hellman J, Ferrer Roca R, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign The surviving sepsis campaign: basic/translational science research priorities. Deutschman CS, Hellman J, Roca RF, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Hellman J, Bahrami S, Boros M, Chaudry IH, Fritsch G, Gozdzik W, Inoue S, Radermacher P, Singer M, Osuchowski MF, Huber-Lang M Premise for Standardized Sepsis Models. Remick DG, Ayala A, Chaudry IH, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski MF NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A Surviving sepsis campaign: research priorities for sepsis and septic shock. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A Detecting Released Peptidoglycan Associated Lipoprotein (Pal) from Escherichia coli. Emma Snyder, Mark Zavorin, Kara Farquaharson, Nicole Panullo, Michael Pichichero, Judith Hellman, Lea Vacca Michel Probing the Two Orientations of Pal in Vesiculating E. coli. Nicole Pannullo, Mark Zavorin, Brooke D'Arcy, Kara Farquharson, Ravinder Kaur, Naveen Surendran, Michael Pichichero, Judith Hellman, Lea Vacca Michel NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K 20. Samira Lawton, Kevin Wilhelmsen, Fengyun Xu, Alphonso Tran, Erika Wong, Judith Hellman Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. Guan Z, Hellman J, Schumacher M Potentiation and tolerance of toll-like receptor priming in human endothelial cells. Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis. Hellman J Vascular endothelial cell Toll-like receptor pathways in sepsis. Khakpour S, Wilhelmsen K, Hellman J Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state. Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. Feng X, Maze M, Koch LG, Britton SL, Hellman J Dual orientation of the outer membrane lipoprotein Pal in Escherichia coli. Michel LV, Shaw J, MacPherson V, Barnard D, Bettinger J, D'Arcy B, Surendran N, Hellman J, Pichichero ME The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J Quantitative in vitro assay to measure neutrophil adhesion to activated primary human microvascular endothelial cells under static conditions. Wilhelmsen K, Farrar K, Hellman J Extracellular signal-regulated kinase 5, a central regulator of Toll-like receptor signaling in vivo and in vitro (P4193). Kevin Wilhelmsen, Fengyun Xu, Alphonso Tran, Judith Hellman Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. Lin T, Sammy F, Yang H, Thundivalappil S, Hellman J, Tracey KJ, Warren HS ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. Wilhelmsen K, Mesa KR, Lucero J, Xu F, Hellman J Bacterial lipopeptides and heat-killed Staph aureus modulate lung vascular endothelial permeability via Toll-like receptor 2 (TLR2) (67.3). Judith Hellman, Kevin Wilhelmsen, Kailin Mesa, Fengyun Xu TLR4 and alveolar macrophages mediate lung ischemia reperfusion (IR) sterile inflammatory injury in a mouse model of ventilated lung ischemia (67.6). Arun Prakash, Kailin Mesa, Judith Hellman Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J Toll-like Receptor 2 signaling in human endothelial cells (162.5). Kevin Wilhelmsen, Kailin Mesa, Judith Hellman Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. Prakash A, Hellman J Resilience to bacterial infection: difference between species could be due to proteins in serum. Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis. Valentine CH, Hellman J, Beasley-Topliffe LK, Bagchi A, Warren HS Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. Liang MD, Bagchi A, Warren HS, Tehan MM, Trigilio JA, Beasley-Topliffe LK, Tesini BL, Lazzaroni JC, Fenton MJ, Hellman J Protective efficacy of CAP18106-138-immunoglobulin G in sepsis. Warren HS, Matyal R, Allaire JE, Yarmush D, Loiselle P, Hellman J, Paton BG, Fink MP Inhaled nitric oxide for ARDS: searching for a more focused use. Bigatello LM, Hellman J Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. Hellman J, Tehan MM, Warren HS Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. Hellman J, Roberts JD, Tehan MM, Allaire JE, Warren HS Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis. Hellman J, Warren HS Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum. Hellman J, Loiselle PM, Tehan MM, Allaire JE, Boyle LA, Kurnick JT, Andrews DM, Sik Kim K, Warren HS Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5. Hellman J, Loiselle PM, Zanzot EM, Allaire JE, Tehan MM, Boyle LA, Kurnick JT, Warren HS Antibodies against bacterial membrane proteins. Judith Hellman, H. Shaw Warren Antiendotoxin strategies. Hellman J, Warren HS Antiserum against Escherichia coli J5 contains antibodies reactive with outer membrane proteins of heterologous gram-negative bacteria. Hellman J, Zanzot EM, Loiselle PM, Amato SF, Black KM, Ge Y, Kurnick JT, Warren HS Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. Sen K, Hellman J, Nikaido H
