Biography Judith Hellman, M.D. is the William L. Young, M.D. Endowed Professor and Vice Chair for Research in the Department of Anesthesia and Perioperative Care at the University of California, San Francisco (UCSF). She is an ICU physician-scientist doing basic-translational research on sepsis and inflammation. She did residencies in Internal Medicine and Anesthesiology, an ICU fellowship, and a post-doctoral T32-funded research fellowship in sepsis. She was on faculty at Harvard Medical School/Massachusetts General Hospital between 1997-2008 and joined the UCSF faculty in 2008. Dr. Hellman’s lab studies immunologic mechanisms and immunomodulation in sepsis and injury, focusing on innate immunity, organ injury and endothelial dysfunction, and on the immune modulating effects of components of Cannabis, of a class of lipids known as vanilloids, and of the endocannabinoid and endovanilloid systems. Role Faculty Location UCSF at Parnassus Category Clinical Research Education 2018 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaM.D., 1989 - School of Medicine, Columbia University Publications Microbial and host inflammatory factors induce permeability and activate cytokine production by human glomerular microvascular endothelial cells. Zhuang C, Xu F, Tsutsui K, Bokoch MP, Hellman J . Shock (Augusta, Ga.) . Sep 12, 2025 Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use. Mohammadi L, Navabzadeh M, Jiménez-Téllez N, Han DD, Reagan E, Naughton J, Zhou LY, Almeida R, Castaneda LM, Abdelaal SA, Park KS, Uyemura K, Cheung CP, Onder MN, Goyal N, Rao P, Hellman J, Cheng J, Wu JC, Marcus GM, Springer ML . JAMA cardiology . May 28, 2025 Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons. Kundu D, Franchini L, Hasdemir HS, Lloyd E, Maturano J, Rabl K, Denissiouk AN, Schumacher M, Sarlah D, Hellman J, Tajkhorshid E, Orlandi C, Das A . Journal of medicinal chemistry . Jun 26, 2025 Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice. Shabani Z, Pan P, Li Q, Wang Z, Leng K, Sangras S, Huo K, Yadav A, Wang C, Shi J, Chinn G, Kyritsis N, Ferguson AR, Hellman J, Su H . bioRxiv : the preprint server for biology . Jun 15, 2025 CRISPR: fundamental principles and implications for anaesthesia. Perez AR, Mavrothalassitis O, Chen JS, Hellman J, Gropper MA . British journal of anaesthesia . Jan 23, 2025 Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation. Gregory DJ, Han F, Li P, Gritsenko MA, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS . Molecular medicine (Cambridge, Mass.) . Dec 28, 2024 Neonatal Cannabidiol Exposure Impairs Spatial Memory and Disrupts Neuronal Dendritic Morphology in Young Adult Rats. Wadhwa M, Chinn GA, Sasaki Russell JM, Hellman J, Sall JW . Cannabis and cannabinoid research . Sep 10, 2024 Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo. Bokoch MP, Xu F, Govindaraju K, Lloyd E, Tsutsui K, Kothari RP, Adelmann D, Joffre J, Hellman J . Frontiers in medicine . Jul 3, 2024 Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s. Roy P, Maturano J, Hasdemir H, Lopez A, Xu F, Hellman J, Tajkhorshid E, Sarlah D, Das A . Journal of natural products . Mar 13, 2024 Surviving Sepsis Campaign Research Priorities 2023. De Backer D, Deutschman CS, Hellman J, Myatra SN, Ostermann M, Prescott HC, Talmor D, Antonelli M, Pontes Azevedo LC, Bauer SR, Kissoon N, Loeches IM, Nunnally M, Tissieres P, Vieillard-Baron A, Coopersmith CM, Surviving Sepsis Campaign Research Committee . Critical Care Medicine . Jan 19, 2024 Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS . medRxiv : the preprint server for health sciences . Nov 30, 2023 Abstract 14589: Impairment of Endothelial Function by Chronic Cannabis Use: An Interim Analysis of the CANDIDE Study. Leila Mohammadi, Mina Navabzadeh, Daniel D Han, Emma Reagan, Jordan Naughton, Lylybell Zhou, Rahul Almeida, Kathryn Park, Keith Uyemura, Natasha Goyal, Poonam Rao, Judith Hellman, Jing Cheng, Gregory M Marcus, Matthew L Springer . Circulation . Nov 7, 2023 The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats. Soni I, Chinn GA, Halifax JC, Lynch KL, Sall JW . Cannabis and cannabinoid research . Oct 18, 2023 Chapter 2 The endocannabinoid system, immunomodulation, and LPS-induced inflammation. Elliot Lloyd, Nina Nguyen, Judith Hellman . Neurobiology and Physiology of the Endocannabinoid System . Jan 1, 2023 Reply to Khatun <i>et al.</i> Joffre J, Matthay MA, Hellman J . American journal of respiratory and critical care medicine . Nov 1, 2022 Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML . Arteriosclerosis, thrombosis, and vascular biology . Oct 26, 2022 COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group . American journal of respiratory and critical care medicine . Oct 15, 2022 Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive. Roy P, Dennis DG, Eschbach MD, Anand SD, Xu F, Maturano J, Hellman J, Sarlah D, Das A . Biochemistry . Oct 12, 2022 A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery. Barreto Chang OL, Whitlock EL, Arias AD, Tsoy E, Allen IE, Hellman J, Bickler PE, Miller B, Possin KL . Journal of the American Geriatrics Society . Sep 20, 2022 A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery. Liao WI, Maruyama D, Kianian F, Tat C, Tian X, Hellman J, Dodd-O JM, Prakash A . Journal of visualized experiments : JoVE . Sep 9, 2022 N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J . Journal of neuroinflammation . May 24, 2022 Triggering toxicity: How antibiotics can enhance the release of outer membrane vesicles from Escherichia coli during sepsis. Lea V. Michel, Anna Konovalova, Judith Hellman, Thomas Gaborski . The FASEB Journal . May 13, 2022 Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122]. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC . Bone . Feb 28, 2022 Abstract 11496: Increased Pulmonary Microvascular Endothelial Permeability by E-Cigarette Aerosol: The Pathway from Lung to Peripheral Blood Vessels. Leila Mohammadi, Daniel D Han, Xiaohui Fang, Fengyun Xu, Ronak Derakhshandeh, Judith Hellman, Jeffrey Gotts, Matthew L Springer . Circulation . Nov 16, 2021 Abstract 9929: Inhibition of Receptor for Advanced Glycation End Products (RAGE) Reduces E-Cigarette-Induced Increase in Endothelial Permeability. Daniel D Han, Fengyun Xu, Ronak Derakhshandeh, Abel Huang, Adam Whitlatch, Rachel J Keith, Naomi Hamburg, Peter Ganz, Judith Hellman, Suzaynn Schick, Matthew L Springer, Leila Mohammadi . Circulation . Nov 16, 2021 Isolation of Primary Mouse Lung Endothelial Cells. Wong E, Nguyen N, Hellman J . Journal of visualized experiments : JoVE . Nov 10, 2021 Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Martin-Loeches I, Nunnally ME, Hellman J, Lat I, Martin GS, Jog S, Kesecioglu J, De Backer D, Coopersmith CM . Critical care explorations . Sep 7, 2021 ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC . Bone . Jul 24, 2021 Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Joffre J, Hellman J . Antioxidants & redox signaling . Apr 9, 2021 The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness. Coopersmith CM, Antonelli M, Bauer SR, Deutschman CS, Evans LE, Ferrer R, Hellman J, Jog S, Kesecioglu J, Kissoon N, Martin-Loeches I, Nunnally ME, Prescott HC, Rhodes A, Talmor D, Tissieres P, De Backer D . Critical Care Medicine . Apr 1, 2021 Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J . Critical Care Medicine . Mar 1, 2021 ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J . Shock (Augusta, Ga.) . Mar 1, 2021 Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. Michel LV, Gallardo L, Konovalova A, Bauer M, Jackson N, Zavorin M, McNamara C, Pierce J, Cheng S, Snyder E, Hellman J, Pichichero ME . International journal of antimicrobial agents . Sep 14, 2020 Endothelial Responses in Sepsis. Joffre J, Hellman J, Ince C, Ait-Oufella H . American journal of respiratory and critical care medicine . Aug 1, 2020 The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities. Deutschman CS, Hellman J, Ferrer Roca R, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign . Critical Care Medicine . Aug 1, 2020 The surviving sepsis campaign: basic/translational science research priorities. Deutschman CS, Hellman J, Roca RF, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign . Intensive care medicine experimental . Jul 17, 2020 Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J . Journal of immunology (Baltimore, Md. : 1950) . May 8, 2020 Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A . Frontiers in microbiology . Feb 14, 2019 Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Hellman J, Bahrami S, Boros M, Chaudry IH, Fritsch G, Gozdzik W, Inoue S, Radermacher P, Singer M, Osuchowski MF, Huber-Lang M . Shock (Augusta, Ga.) . Jan 1, 2019 Premise for Standardized Sepsis Models. Remick DG, Ayala A, Chaudry IH, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski MF . Shock (Augusta, Ga.) . Jan 1, 2019 NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC . JCI Insight . Nov 15, 2018 Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B . Shock (Augusta, Ga.) . Oct 1, 2018 Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B . Intensive care medicine experimental . Aug 14, 2018 Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A . Critical Care Medicine . Aug 1, 2018 Surviving sepsis campaign: research priorities for sepsis and septic shock. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A . Intensive care medicine . Jul 3, 2018 Detecting Released Peptidoglycan Associated Lipoprotein (Pal) from Escherichia coli. Emma Snyder, Mark Zavorin, Kara Farquaharson, Nicole Panullo, Michael Pichichero, Judith Hellman, Lea Vacca Michel . The FASEB Journal . Apr 1, 2018 Probing the Two Orientations of Pal in Vesiculating E. coli. Nicole Pannullo, Mark Zavorin, Brooke D'Arcy, Kara Farquharson, Ravinder Kaur, Naveen Surendran, Michael Pichichero, Judith Hellman, Lea Vacca Michel . The FASEB Journal . Apr 1, 2018 NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A . Frontiers in immunology . Oct 31, 2017 N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K . Journal of immunology (Baltimore, Md. : 1950) . Jul 12, 2017 20. Samira Lawton, Kevin Wilhelmsen, Fengyun Xu, Alphonso Tran, Erika Wong, Judith Hellman . Critical Care Medicine . Dec 1, 2016 Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. Guan Z, Hellman J, Schumacher M . F1000Research . Sep 30, 2016 Potentiation and tolerance of toll-like receptor priming in human endothelial cells. Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ . Translational research : the journal of laboratory and clinical medicine . Aug 8, 2016 Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G . Immunity . Mar 2, 2016 Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis. Hellman J . PLoS pathogens . Oct 1, 2015 Vascular endothelial cell Toll-like receptor pathways in sepsis. Khakpour S, Wilhelmsen K, Hellman J . Innate immunity . Sep 23, 2015 Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J . Shock (Augusta, Ga.) . Sep 1, 2015 Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J . Science signaling . Aug 25, 2015 Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state. Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM . Journal of leukocyte biology . Jul 27, 2015 Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. Feng X, Maze M, Koch LG, Britton SL, Hellman J . PloS one . May 15, 2015 Dual orientation of the outer membrane lipoprotein Pal in Escherichia coli. Michel LV, Shaw J, MacPherson V, Barnard D, Bettinger J, D'Arcy B, Surendran N, Hellman J, Pichichero ME . Microbiology (Reading, England) . Mar 25, 2015 The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J . The Journal of biological chemistry . Mar 18, 2014 Quantitative in vitro assay to measure neutrophil adhesion to activated primary human microvascular endothelial cells under static conditions. Wilhelmsen K, Farrar K, Hellman J . Journal of visualized experiments : JoVE . Aug 23, 2013 Extracellular signal-regulated kinase 5, a central regulator of Toll-like receptor signaling in vivo and in vitro (P4193). Kevin Wilhelmsen, Fengyun Xu, Alphonso Tran, Judith Hellman . The Journal of Immunology . May 1, 2013 Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J . Anesthesiology . Oct 1, 2012 Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. Lin T, Sammy F, Yang H, Thundivalappil S, Hellman J, Tracey KJ, Warren HS . Journal of immunology (Baltimore, Md. : 1950) . Jul 6, 2012 ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. Wilhelmsen K, Mesa KR, Lucero J, Xu F, Hellman J . The Journal of biological chemistry . Jun 15, 2012 Bacterial lipopeptides and heat-killed Staph aureus modulate lung vascular endothelial permeability via Toll-like receptor 2 (TLR2) (67.3). Judith Hellman, Kevin Wilhelmsen, Kailin Mesa, Fengyun Xu . The Journal of Immunology . May 1, 2012 TLR4 and alveolar macrophages mediate lung ischemia reperfusion (IR) sterile inflammatory injury in a mouse model of ventilated lung ischemia (67.6). Arun Prakash, Kailin Mesa, Judith Hellman . The Journal of Immunology . May 1, 2012 Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J . Innate immunity . Dec 20, 2011 Toll-like Receptor 2 signaling in human endothelial cells (162.5). Kevin Wilhelmsen, Kailin Mesa, Judith Hellman . The Journal of Immunology . Apr 1, 2011 Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J . Journal of immunology (Baltimore, Md. : 1950) . Dec 17, 2010 Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. Prakash A, Hellman J . Journal of leukocyte biology . Oct 1, 2010 Resilience to bacterial infection: difference between species could be due to proteins in serum. Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM . The Journal of infectious diseases . Jan 15, 2010 Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M . AIDS (London, England) . Mar 12, 2008 Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J . American journal of physiology. Lung cellular and molecular physiology . Nov 30, 2007 MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M . Journal of virology . May 16, 2007 Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U . Critical Care Medicine . Mar 1, 2007 MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J . Journal of immunology (Baltimore, Md. : 1950) . Jan 15, 2007 Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis. Valentine CH, Hellman J, Beasley-Topliffe LK, Bagchi A, Warren HS . Molecular medicine (Cambridge, Mass.) . Sep 1, 2006 Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U . Critical Care Medicine . Mar 1, 2005 Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. Liang MD, Bagchi A, Warren HS, Tehan MM, Trigilio JA, Beasley-Topliffe LK, Tesini BL, Lazzaroni JC, Fenton MJ, Hellman J . The Journal of infectious diseases . Feb 8, 2005 Protective efficacy of CAP18106-138-immunoglobulin G in sepsis. Warren HS, Matyal R, Allaire JE, Yarmush D, Loiselle P, Hellman J, Paton BG, Fink MP . The Journal of infectious diseases . Oct 20, 2003 Inhaled nitric oxide for ARDS: searching for a more focused use. Bigatello LM, Hellman J . Intensive care medicine . Oct 1, 2003 Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. Hellman J, Tehan MM, Warren HS . The Journal of infectious diseases . Jul 1, 2003 Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. Hellman J, Roberts JD, Tehan MM, Allaire JE, Warren HS . The Journal of biological chemistry . Feb 5, 2002 Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis. Hellman J, Warren HS . Journal of endotoxin research . Jan 1, 2001 Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum. Hellman J, Loiselle PM, Tehan MM, Allaire JE, Boyle LA, Kurnick JT, Andrews DM, Sik Kim K, Warren HS . Infection and immunity . May 1, 2000 Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5. Hellman J, Loiselle PM, Zanzot EM, Allaire JE, Tehan MM, Boyle LA, Kurnick JT, Warren HS . The Journal of infectious diseases . Mar 1, 2000 Antibodies against bacterial membrane proteins. Judith Hellman, H. Shaw Warren . Innate immunity . Aug 1, 1999 Antiendotoxin strategies. Hellman J, Warren HS . Infectious disease clinics of North America . Jun 1, 1999 Antiserum against Escherichia coli J5 contains antibodies reactive with outer membrane proteins of heterologous gram-negative bacteria. Hellman J, Zanzot EM, Loiselle PM, Amato SF, Black KM, Ge Y, Kurnick JT, Warren HS . The Journal of infectious diseases . Nov 1, 1997 Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. Sen K, Hellman J, Nikaido H . The Journal of biological chemistry . Jan 25, 1988
