Overview Mitogen-activated protein kinases (MAPK’s) play key roles in inflammatory signaling. Studies by ours and other groups have implicated ERK1/2 and ERK5 in TLR-dependent signaling. We identified novel roles for ERK1/2 and ERK5, in the activation of leukocytes and endothelial cells by bacterial TLR agonists and host inflammatory factors (e.g.:TNF⍺, IL-1β). Our work suggests that ERK1/2 activation plays divergent roles in the inflammatory activation of human endothelial cells versus leukocytes by TLR2 and TLR4 agonists. Affiliated Lab Hellman Lab Principal investigator UCSF Judith Hellman, MD Professor Seeking collaborators Our project is looking for individuals to join our team. Get in touch if you’d like to learn more. Email Us Support this research Are you excited by the innovative work we’re doing on this project? Learn how your financial support can make the difference in our work. Support
