Biography Dr. Zhonghui Guan is an anesthesiologist and pain management specialist. He has particular expertise in treating chronic pain, including low back pain, neck pain, neuropathic pain, complex regional pain syndrome, failed back surgery syndrome and cancer pain. In his research, Guan focuses on better understanding the regulation of gene expression in chronic pain. Gene expression regulation is essentially cell processes that control synthesis of proteins or other products that play a role in body functions. Guan earned his medical degree at Peking Union Medical College in Beijing. He completed an anesthesia residency at Massachusetts General Hospital, followed by a pain management fellowship at UCSF. Guan is a member of numerous professional organizations, including the American Society of Anesthesiologists, California Society of Anesthesiologists and Society for Neuroscience. Role Faculty Location UCSF at Mission Bay Category Clinical Research Specialties Pain Medicine Education 08/2009 - Clinical Pain Fellow, UCSF08/2008 - Anesthesia Resident, Massachusetts General Hospital07/2004 - Associate Research Scientist, Columbia University04/1999 - Postdoctoral Research Scientist, National Institute of Health (NIH)MD, 07/1994 - Medicine, Peking Union Medical College (PUMC) Publications Higher circulating short-chain fatty acids are associated with good neurologic outcome after cardiac arrest. Lieberman OJ, Yao V, Velasquez G, Otero M, Bao K, Peterson K, Kobeissy FH, Pan JZ, Guan Z, Hinson HE, Baranzini SE, Hemphill JC, Singhal NS, Amorim E Critical care (London, England) . Aug 20, 2025 Editorial: Microglia and tissue macrophages in pain. Mohsenin D, Yu J, Guan Z, Yu X Frontiers in immunology . Aug 7, 2025 Saphenous-sural nerve injury: a sensory-specific rodent model of neuropathic pain without motor deficits. Su PP, He L, Zhang L, Yu J, Guan Z Pain . Aug 4, 2025 Orexinergic projections to substantia innominata mediate arousal and analgesia. Xiang X, Wang F, Chen C, Guan Z, Zhou W British journal of anaesthesia . Jul 8, 2025 A Novel Ultrasonographic Method to Quickly and Accurately Access the C2 Dorsal Root Ganglion. He L, Zhao W, Su PP, Liao X, Zhao J, Dou Z, Wang H, Yang L, Guan Z Pain physician . Nov 1, 2024 Orexinergic projections to substantia innominata mediate arousal and analgesia. Xiang X, Wang F, Chen C, Guan Z, Zhou W bioRxiv : the preprint server for biology . Oct 31, 2024 ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z Clinical and translational medicine . Apr 1, 2024 Mismatched Postsurgical Opioid Prescription to Liver Transplant Patients: A Retrospective Cohort Study From a Single High-volume Transplant Center. Chen VJ, Guan LS, Bokoch MP, Langnas E, Kothari R, Croci R, Campbell LJ, Quan D, Freise C, Guan Z Transplantation . Jan 19, 2024 Opioid Overprescription and Underprescription to Patients After Otolaryngology-Head and Neck Surgery. Kuo J, Langnas E, Zhang L, Seth R, Guan Z JAMA otolaryngology-- head & neck surgery . Aug 1, 2023 Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study. Campbell LJ, Mummaneni PV, Letchuman V, Langnas E, Agarwal N, Guan LS, Croci R, Vargas E, Reisner L, Bickler P, Chou D, Chang E, Guan Z Pain . Jun 15, 2023 A Procedure for Mouse Dorsal Root Ganglion Cryosectioning. He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z Journal of visualized experiments : JoVE . Jun 9, 2023 Discharge Opioid Over- and Underprescription to Patients after General Surgery: A Retrospective Cohort Study. Guan LS, Langnas E, Bongiovanni T, Campbell LJ, Wick EC, Guan Z Journal of the American College of Surgeons . Apr 25, 2023 Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients. Letchuman V, He L, Mummaneni PV, Agarwal N, Campbell LJ, Shabani S, Chan AK, Abrecht CR, Miller C, Sankaran S, Rambachan A, Croci R, Berven SH, Chou D, Holly LT, Guan Z Neurosurgery . Nov 16, 2022 The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice. Su PP, Zhang L, He L, Zhao N, Guan Z Journal of pain research . Aug 4, 2022 Opioid prescribing practices at hospital discharge for surgical patients before and after the Centers for Disease Control and Prevention's 2016 opioid prescribing guideline. Langnas E, Bishara A, Croci R, Rodriguez-Monguio R, Wick EC, Chen CL, Guan Z BMC anesthesiology . May 11, 2022 Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control. Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W Frontiers in cellular neuroscience . Apr 26, 2022 Identification of Foramen Ovale With H-Figure Fluoroscopic Landmark Improves Treatment Outcomes in Idiopathic Trigeminal Neuralgia. He LL, Zhao WX, Paul Su PY, Sun QR, Guo GL, Yue JN, Ni JX, Yang LQ, Guan Z Anesthesia and analgesia . Apr 15, 2022 Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase. Tan W, Su PP, Leff J, Gao X, Chen J, Guan AK, Kalyanasundaram G, Ma A, Guan Z Cell discovery . Apr 12, 2022 Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice. He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z Journal of visualized experiments : JoVE . Jan 25, 2022 Function of Oncogene Mycn in Adult Neurogenesis and Oligodendrogenesis. Chen J, Guan Z Molecular neurobiology . Oct 8, 2021 Novel method of locating the foramen ovale: a stable chair with solid legs. He L, Guan Z Regional anesthesia and pain medicine . May 5, 2021 Perioperative Use of Gabapentinoids: Comment. Su PP, Guan Z Anesthesiology . Apr 1, 2021 Contribution of colony-stimulating factor 1 to neuropathic pain. Yu X, Basbaum A, Guan Z Pain reports . Mar 9, 2021 Ion Channels in Anesthesia. Zhou W, Guan Z Advances in experimental medicine and biology . Jan 1, 2021 Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia. He L, Zhao W, Su PP, Guo G, Yue J, Ni J, Yang L, Guan Z Regional anesthesia and pain medicine . Dec 16, 2020 Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI Nature communications . Jan 14, 2020 Rapid Isolation of Dorsal Root Ganglion Macrophages. Yu X, Leff J, Guan Z Journal of visualized experiments : JoVE . Sep 7, 2019 Case Report and Literature Review: Interventional Management of Erythromelalgia. Chinn G, Guan Z Translational perioperative and pain medicine . Jul 29, 2019 Spinal Cord Stimulation for Failed Back Surgery Syndrome -- Patient Selection Considerations. Palmer N, Guan Z, Chai NC Translational perioperative and pain medicine . Jun 21, 2019 Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava. Chen K, Wang J, Dai J, Luo A, Tian Y, Guan Z, Wang X Tumori . Apr 2, 2019 Transcription factor Sp4 is required for hyperalgesic state persistence. Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M PloS one . Feb 27, 2019 Activation of orexin system facilitates anesthesia emergence and pain control. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY Proceedings of the National Academy of Sciences of the United States of America . Oct 22, 2018 A consensus on immunotherapy from the 2017 Chinese Lung Cancer Summit expert panel. Wu YL, Wang CL, Liao ML, Guan ZZ, Gao CY, Lu S, Zhao MF, Wang J, Liu XQ, Yang JJ, Liang J, Mao WM, Han BH, Zhang XC, Song Y, Feng JF, Ma SL, Wu G, Zhou CC, Chen KN, Cheng Y, He Y, Chen C, Wang Q, Lin JZ, Zhu B, Liu YP, Hu Y, Qiao GB, Zhou Q, Song QB, Wu N, Wu L, Huang C, Fu XL, Xiong JP, Hu J, Hu CP, Chang JH, Zhao Q, Zhao J, Zhou PH, Ma ZY, Chen Y, Zhang HL, Yang F, Wang JJ, Pan YY, Yang XN, Fan Y, Liu Z, Fan W, Yang N, Guan YF, Sun H, Zhong WZ Translational lung cancer research . Jun 1, 2018 Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. Guan Z, Hellman J, Schumacher M F1000Research . Sep 30, 2016 Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI Nature neuroscience . Dec 7, 2015 Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI Pain . Jun 1, 2015 Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI The Journal of neuroscience : the official journal of the Society for Neuroscience . Jan 14, 2015 A double-blind, randomized phase II study of dicycloplatin plus paclitaxel versus carboplatin plus paclitaxel as first-line therapy for patients with advanced non-small-cell lung cancers. Liu KJ, Guan ZZ, Liang Y, Yang XQ, Peng J, Huang H, Shao QX, Wang MZ, Zhu YZ, Wu CP, Wang SB, Xiong JP, Bai YX, Yu SY, Zhang Y, Hu XH, Feng JF, Wu SX, Jiao SC, Zhou CC, Wang J, Wu HY Archives of medical science : AMS . Aug 29, 2014 Clinical characteristics and prognostic factors in Chinese patients with Hodgkin's lymphoma. Zhu YJ, Sun YL, Xia Y, Jiang WQ, Huang JJ, Huang HQ, Lin TY, Guan ZZ, Li ZM Medical oncology (Northwood, London, England) . Mar 10, 2011 Misalignment of disposable pulse oximeter probes results in false saturation readings that influence anesthetic management. Guan Z, Baker K, Sandberg WS Anesthesia and analgesia . Nov 1, 2009 The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes. Yu JX, Guan Z, Nash HA Genetics . Mar 1, 2006 CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH Proceedings of the National Academy of Sciences of the United States of America . Dec 27, 2005 p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH The Journal of neuroscience : the official journal of the Society for Neuroscience . Aug 13, 2003 [Relationship between tumor necrosis factor genetic polymorphisms and acute lymphocytic leukemia]. Zhao HY, Chen YX, Lin XB, Zhong XY, Zhong LY, Ou RM, Jiang WQ, Guan ZZ Ai zheng = Aizheng = Chinese journal of cancer . Aug 1, 2003 Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER Cell . Nov 15, 2002 Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled-coil protein. Guan Z, Prado A, Melzig J, Heisenberg M, Nash HA, Raabe T Proceedings of the National Academy of Sciences of the United States of America . Jul 5, 2000 A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region. Guan Z, Scott RL, Nash HA Journal of neurogenetics . Apr 1, 2000
