Biography Dr. Zhonghui Guan is an anesthesiologist and pain management specialist. He has particular expertise in treating chronic pain, including low back pain, neck pain, neuropathic pain, complex regional pain syndrome, failed back surgery syndrome and cancer pain. In his research, Guan focuses on better understanding the regulation of gene expression in chronic pain. Gene expression regulation is essentially cell processes that control synthesis of proteins or other products that play a role in body functions. Guan earned his medical degree at Peking Union Medical College in Beijing. He completed an anesthesia residency at Massachusetts General Hospital, followed by a pain management fellowship at UCSF. Guan is a member of numerous professional organizations, including the American Society of Anesthesiologists, California Society of Anesthesiologists and Society for Neuroscience. Role Faculty Location UCSF at Mission Bay Category Clinical Research Specialties Pain Medicine Education 08/2009 - Clinical Pain Fellow, UCSF08/2008 - Anesthesia Resident, Massachusetts General Hospital07/2004 - Associate Research Scientist, Columbia University04/1999 - Postdoctoral Research Scientist, National Institute of Health (NIH)MD, 07/1994 - Medicine, Peking Union Medical College (PUMC) Publications ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z Mismatched Postsurgical Opioid Prescription to Liver Transplant Patients: A Retrospective Cohort Study From a Single High-volume Transplant Center. Chen VJ, Guan LS, Bokoch MP, Langnas E, Kothari R, Croci R, Campbell LJ, Quan D, Freise C, Guan Z Opioid Overprescription and Underprescription to Patients After Otolaryngology-Head and Neck Surgery. Kuo J, Langnas E, Zhang L, Seth R, Guan Z Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study. Campbell LJ, Mummaneni PV, Letchuman V, Langnas E, Agarwal N, Guan LS, Croci R, Vargas E, Reisner L, Bickler P, Chou D, Chang E, Guan Z A Procedure for Mouse Dorsal Root Ganglion Cryosectioning. He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z Discharge Opioid Over- and Underprescription to Patients after General Surgery: A Retrospective Cohort Study. Guan LS, Langnas E, Bongiovanni T, Campbell LJ, Wick EC, Guan Z Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients. Letchuman V, He L, Mummaneni PV, Agarwal N, Campbell LJ, Shabani S, Chan AK, Abrecht CR, Miller C, Sankaran S, Rambachan A, Croci R, Berven SH, Chou D, Holly LT, Guan Z The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice. Su PP, Zhang L, He L, Zhao N, Guan Z Opioid prescribing practices at hospital discharge for surgical patients before and after the Centers for Disease Control and Prevention's 2016 opioid prescribing guideline. Langnas E, Bishara A, Croci R, Rodriguez-Monguio R, Wick EC, Chen CL, Guan Z Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control. Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W Identification of Foramen Ovale With H-Figure Fluoroscopic Landmark Improves Treatment Outcomes in Idiopathic Trigeminal Neuralgia. He LL, Zhao WX, Paul Su PY, Sun QR, Guo GL, Yue JN, Ni JX, Yang LQ, Guan Z Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase. Tan W, Su PP, Leff J, Gao X, Chen J, Guan AK, Kalyanasundaram G, Ma A, Guan Z Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice. He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z Function of Oncogene Mycn in Adult Neurogenesis and Oligodendrogenesis. Chen J, Guan Z Novel method of locating the foramen ovale: a stable chair with solid legs. He L, Guan Z Perioperative Use of Gabapentinoids: Comment. Su PP, Guan Z Contribution of colony-stimulating factor 1 to neuropathic pain. Yu X, Basbaum A, Guan Z Ion Channels in Anesthesia. Zhou W, Guan Z Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia. He L, Zhao W, Su PP, Guo G, Yue J, Ni J, Yang L, Guan Z Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI Rapid Isolation of Dorsal Root Ganglion Macrophages. Yu X, Leff J, Guan Z Case Report and Literature Review: Interventional Management of Erythromelalgia. Chinn G, Guan Z Spinal Cord Stimulation for Failed Back Surgery Syndrome -- Patient Selection Considerations. Palmer N, Guan Z, Chai NC Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava. Chen K, Wang J, Dai J, Luo A, Tian Y, Guan Z, Wang X Transcription factor Sp4 is required for hyperalgesic state persistence. Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M Activation of orexin system facilitates anesthesia emergence and pain control. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. Guan Z, Hellman J, Schumacher M Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI Misalignment of disposable pulse oximeter probes results in false saturation readings that influence anesthetic management. Guan Z, Baker K, Sandberg WS The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes. Yu JX, Guan Z, Nash HA CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled-coil protein. Guan Z, Prado A, Melzig J, Heisenberg M, Nash HA, Raabe T A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region. Guan Z, Scott RL, Nash HA
