Spencer Yost, MD

Professor of Clinical Anesthesia
Vice Chair for Strategic Development
Chief of Anesthesia, Mission Bay
Medical Director Mission Bay A4 ICU
Executive Vice Chair UCSF-Mission Bay IACUC Panel
Publications: 
Sarin A, Litonius ES, Naidu R, Yost CS, Varma MG, Chen LL. Successful implementation of an Enhanced Recovery After Surgery program shortens length of stay and improves postoperative pain, and bowel and bladder function after colorectal surgery. BMC Anesthesiol. 2016 08 03; 16(1):55.
Anderson A, Eilers H, Yost CS. Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case report. Transplant Proc. 2010 Jun; 42(5):1967-9.
Yoo S, Liu J, Sabbadini M, Au P, Xie GX, Yost CS. Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci Lett. 2009 Nov 06; 465(1):79-84.
Sabbadini M, Yost CS. Molecular biology of background K channels: insights from K(2P) knockout mice. J Mol Biol. 2009 Feb 06; 385(5):1331-44.
Yost CS, Oh I, Eger EI, Sonner JM. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Behav Brain Res. 2008 Nov 21; 193(2):192-6.
Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter; 12(3-4):236-49.
Cotten JF, Keshavaprasad B, Laster MJ, Eger EI, Yost CS. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg. 2006 Mar; 102(3):779-85.
Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK. Anesth Analg. 2005 Oct; 101(4):1042-9, table of contents.
Paul M, Callahan R, Au J, Kindler CH, Yost CS. Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesth Analg. 2005 Sep; 101(3):715-21, table of contents.
Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73.
Cotten JF, Zou HL, Liu C, Au JD, Yost CS. Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Brain Res Mol Brain Res. 2004 Sep 28; 128(2):112-20.
Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS. Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):525-30.
Callahan RJ, Au JD, Paul M, Liu C, Yost CS. Functional inhibition by methadone of N-methyl-D-aspartate receptors expressed in Xenopus oocytes: stereospecific and subunit effects. Anesth Analg. 2004 Mar; 98(3):653-9, table of contents.
Mhatre AN, Li J, Chen AF, Yost CS, Smith RJ, Kindler CH, Lalwani AK. Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4. J Neurosci Res. 2004 Jan 01; 75(1):25-31.
Yost CS. Update on tandem pore (2P) domain K+ channels. Curr Drug Targets. 2003 May; 4(4):347-51.
Niemann CU, Roberts JP, Ascher NL, Yost CS. Intraoperative hemodynamics and liver function in adult-to-adult living liver donors. Liver Transpl. 2002 Dec; 8(12):1126-32.
Paul M, Fokt RM, Kindler CH, Dipp NC, Yost CS. Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor. Anesth Analg. 2002 Aug; 95(2):362-7, table of contents.
Niemann CU, Yost CS, Mandell S, Henthorn TK. Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients. Liver Transpl. 2002 May; 8(5):476-81.
Paul M, Kindler CH, Fokt RM, Dipp NC, Yost CS. Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site. Eur J Pharmacol. 2002 Mar 01; 438(1-2):35-43.
Paul M, Kindler CH, Fokt RM, Dresser MJ, Dipp NC, Yost CS. The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors. Anesth Analg. 2002 Mar; 94(3):597-603; table of contents.
Yost CS, Matthay MA, Gropper MA. Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Chest. 2001 Jan; 119(1):219-23.
Yost CS. Tandem pore domain K channels: an important site of volatile anesthetic action? Curr Drug Targets. 2000 Sep; 1(2):207-17.
Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS. Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5. Anesthesiology. 2000 Jun; 92(6):1722-30.
Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS. Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Anesthesiology. 2000 Mar; 92(3):821-32.
Kindler CH, Yost CS, Gray AT. Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem. Anesthesiology. 1999 Apr; 90(4):1092-102.
Yost CS. Potassium channels: basic aspects, functional roles, and medical significance. Anesthesiology. 1999 Apr; 90(4):1186-203.
Gray AT, Kindler CH, Sampson ER, Yost CS. Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet Cell Genet. 1999; 84(3-4):190-1.
Winegar BD, Yost CS. Activation of single potassium channels in rat cerebellar granule cells by volatile anesthetics. Toxicol Lett. 1998 Nov 23; 100-101:287-91.
Yost CS, Gray AT, Winegar BD, Leonoudakis D. Baseline K+ channels as targets of general anesthetics: studies of the action of volatile anesthetics on TOK1. Toxicol Lett. 1998 Nov 23; 100-101:293-300.
Winegar BD, Yost CS. Volatile anesthetics directly activate baseline S K+ channels in aplysia neurons. Brain Res. 1998 Oct 05; 807(1-2):255-62.
Yost CS, Hampson AJ, Leonoudakis D, Koblin DD, Bornheim LM, Gray AT. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth Analg. 1998 Jun; 86(6):1294-300.
Gray AT, Winegar BD, Leonoudakis DJ, Forsayeth JR, Yost CS. TOK1 is a volatile anesthetic stimulated K+ channel. Anesthesiology. 1998 Apr; 88(4):1076-84.
Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci. 1998 Feb 01; 18(3):868-77.
Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. J Neurochem. 1998 Feb; 70(2):671-6.
Gray AT, Leonoudakis DJ, Yost CS. An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc. Brain Res Mol Brain Res. 1997 Dec 01; 52(1):157-61.
Gorman S, Viseshakul N, Cohen B, Hardy S, Grant GA, Yost CS, Forsayeth JR. A recombinant adenovirus that directs secretion of biologically active kappa-bungarotoxin from mammalian cells. Brain Res Mol Brain Res. 1997 Feb; 44(1):143-6.
Yost CS, Winegar BD. Potency of agonists and competitive antagonists on adult- and fetal-type nicotinic acetylcholine receptors. Cell Mol Neurobiol. 1997 Feb; 17(1):35-50.
Winegar BD, Owen DF, Yost CS, Forsayeth JR, Mayeri E. Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels. Anesthesiology. 1996 Oct; 85(4):889-900.
De Fea KA, Nakahara DH, Calayag MC, Yost CS, Mirels LF, Prusiner SB, Lingappa VR. Determinants of carboxyl-terminal domain translocation during prion protein biogenesis. J Biol Chem. 1994 Jun 17; 269(24):16810-20.
Yost CS, Maestrone E. Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor. Anesth Analg. 1994 Mar; 78(3):520-6.
Yost CS. G proteins: basic characteristics and clinical potential for the practice of anesthesia. Anesth Analg. 1993 Oct; 77(4):822-34.
Yost CS, Dodson BA. Inhibition of the nicotinic acetylcholine receptor by barbiturates and by procaine: do they act at different sites? Cell Mol Neurobiol. 1993 Apr; 13(2):159-72.
Schwartz DE, Yost CS, Larson MD. Pneumothorax complicating the use of a Univent endotracheal tube. Anesth Analg. 1993 Feb; 76(2):443-5.
Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science. 1990 Apr 13; 248(4952):226-9.
Yost CS, Lopez CD, Prusiner SB, Myers RM, Lingappa VR. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. Nature. 1990 Feb 15; 343(6259):669-72.