Bin Liu, PhD
Professor
Publications:
Zhu, I., Liu, R., Garcia, J.M., Hyrenius-Wittsten, A., Piraner, D., Alavi, J., Israni, D.V., Liu, B., Khalil, A.S., Roybal, K.T. . Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies. Cell. 2022; 8(185):1431-1443.
Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J.. Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 2022; (40):16_s3001.
Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J.M., Perry, N., Montgomery, G., Liu, B*., Roybal, K.T*. Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits. Science Translational Medicine. 2021; 591(13):eabd8836.
Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D., Zhao, W., Jayaraman, M., Huynh, T.L., Zhao, N., Wang, Y.H., Huang, Y., Qin, F., Shen, S., Gioeli, D., Dreicer, R., Sriram, R., Egusa, E.A., Chou, J., Feng, F., Aggarwal, R., Evans, M.J., Seo, Y., Liu, B.*, Flavell, R.R.*, He, J.* . Molecular imaging of prostate cancer targeting CD46 using immunoPET. Clinical Cancer Res. 2020; 5(27):1305-1315.
Sherbenou, D.W., Su, Y., Behrens, C.R., Aftab, B.T., Perez de Acha, O., Murnane, M., Bearrows, S.C., Hann, B.C., Wolf, J.L., Martin, T.G., and Liu, B.. Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma. Clinical Cancer Res. 2020; 22(26):6028-6038.
Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B.. ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res. 2020; 20(80):4552-4564.
He, J., Feng, J., Su, Y., Seo, Y., and Liu, B.. Quantitative (99m)Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma. Bioconjug Chem. 2020; 7(31):1750-1755.
Lee, N.K., Su, Y., Bidlingmaier, S., and Liu, B.. Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design. Mol Cancer Ther. 2019; 6(18):1092-1103.
Su, Y., Liu, Y., Behrens, C.R., Bidlingmaier, S., Lee, N.K., Aggarwal, R., Sherbenou, D.W., Burlingame, A.L., Hann, B.C., Simko, J.P., Premasekharan, G., Paris, P.L., Shuman, M.A., Seo, Y., Small, E.J., and Liu, B.. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018; 17(3):e121497.
Lee, N.K., Zhang, Y., Su, Y., Bidlingmaier, S., Sherbenou, D.W., Ha, K.D., Liu, B.. Cell-type specific potent Wnt signaling blockade by bispecific antibody. Sci Rep. 2018; 1(8):766.
Su, Y., Bidlingmaier, S., Lee, N.K., Liu, B.. Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens. Methods Mol Biol. 2018; (1701):331-347.
Lee, N.K., Bidlingmaier, S., Su, Y., Liu, B.. Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes. Methods Mol Biol. 2018; (1701):61-82.
Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.. Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis. Methods Enzymol. 2017; (585):91-110.
Sherbenou, D.W., Aftab, B.T., Su, Y., Behrens, C.R., Wiita, A., Logan, A.C., Acosta-Alvear, D., Hann, B.C., Walter, P., Shuman, M.A., Wu, X., Atkinson, J.P., Wolf, J.L., Martin, T.G., Liu, B.. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016; 12(126):4640-4653.
Bidlingmaier, S., Ha, K., Lee, N.K., Su, Y., Liu, B.. Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing. Mol Cell Proteomics. 2016; 4(15):1232-45.
Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.. Macropinocytosis exploitation by cancers and cancer therapy. Frontier Physiology. 2016; (7):381.
Bidlingmaier, S., Liu, B.. Combining phage and yeast cell surface antibody display to identify novel cell type-selective internalizing human monoclonal antibodies. Methods Mol Biol. 2015; (1319):51-63.
Bidlingmaier, S., Su, Y., and Liu, B.. Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries. Methods Mol Biol. 2015; (1319):193-202.
Bidlingmaier, S., Liu, B.. Identification of novel protein-ligand interactions by exon microarray analysis of yeast surface displayed cDNA library selection outputs. Methods Mol Biol. 2015; (1319):179-92.
Sherbenou, D.W., Behrens, C.R. Yang Su, Wolf, J.L., Martin III, T.G., and Liu, B.. The Development of Potential Antibody-Based Therapies for Multiple Myeloma. Blood Rev. 2015; 2(29):81-91.
Bidlingmaier, S. and Liu, B.. Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions. Methods Mol Biol. 2015; (1319):203-14.
Behrens CR, Liu B. Methods for site-specific drug conjugation to antibodies. MAbs. 2014 Jan-Feb; 6(1):46-53.
Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906.
McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM. An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. Mol Imaging Biol. 2012 Jun; 14(3):336-47.
Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 01; 71(7):2428-32.
Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13.
Bidlingmaier S, Liu B. Construction of yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:199-210.
Bidlingmaier S, Liu B. Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:211-23.
Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B. Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics. 2011 Mar; 10(3):M110.005116.
Chen Y, Zhu X, Zhang X, Liu B, Huang L. Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther. 2010 Sep; 18(9):1650-6.
Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S., and Liu, B.. Identification of internalizing human single antibodies targeting brain tumor stem cells. Mol Cancer Ther. 2010; 7(9):2131-41.
He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B.. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment. J Nucl Med. 2010; 3(51):417-32.
Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB. Development of a highly stable and targetable nanoliposomal formulation of topotecan. J Control Release. 2010 Jan 04; 141(1):13-21.
Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7.
Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B.. Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med. 2009; 5(87):507-14.
An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B.. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies. Mol Cancer Ther. 2008; 3(7):569-78.
Bidlingmaier, S., Zhu, X., and Liu, B.. The utility and limitation of CD133 epitopes in defining tumor stem cell population. J Mol Med. 2008; 9(86):1025-32.
Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol. 2007 Jul; 44(15):3777-88.
Roth, A, Conrad, F., Hayes, M., Drummond, D.C., Kirpotin, D.B., Benz, C.C., Marks, J.D., and Liu, B.. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther. 2007; 10(6):2737-46.
Liu, B.. Explore Cell Type-Specific Internalizing Antibodies For Targeted siRNA Delivery. Brief Funct Genomic Proteomic. 2007; 2(6):112-9.
Bidlingmaier, S and Liu, B.. Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins. Mol Cell Proteomics. 2007; 11(6):2012-20.
Liu, B., Conrad, F., Roth, A., Drummond, D.C and Marks, J.D.. Prostate cancer targeting recombinant human IgG1s. J Mol Med. 2007; 10(85):1113-23.
Bidlingmaier, S. and Liu, B.. Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol Cell Proteomics. 2006; 3(5):533-40.
Ruan, W., Sassoon, A., An, F., Simko, J.P., Liu, B.. Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection. Mol Cell Proteomics. 2006; 12(5):2364-73.
Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D.. Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells. Cancer Res. 2004; 2(64):704-710.
Liu, B., Huang, L., Burlingame, A.L., Marks, J.D.. Towards proteome-wide production of monoclonal antibody by phage display. J Mol Biol. 2002; 5(315):1063-1073.
Liu B, Marks JD. Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Anal Biochem. 2000 Nov 01; 286(1):119-28.
Liu B, Alberts BM. Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science. 1995 Feb 24; 267(5201):1131-7.
Diamond MA. Organizational change as human process, not technique. NIDA Res Monogr. 1995; 155:119-31.
Liu B, Wong ML, Alberts B. A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10660-4.
Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM. The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature. 1993 Nov 04; 366(6450):33-9.