Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Education Ph.D., 1994 - Biochemistry & Biophysics, University of CaliforniaB.A., 1990 - Molecular Biology, Princeton University Publications A phase 1b dose escalation study of FOR46, a novel antibody-drug conjugate targeting a tumor-specific epitope of CD46, in combination with enzalutamide (Enza) in patients with metastatic castration resistant prostate cancer (mCRPC) Nonna Shakhnazaryan, Nathan Curry, Medini Rastogi, Daniel Avins, Shrina Pandey, Ivan de Kouchkovsky, Daniel Kwon, Arpita Desai, Kelly N. Fitzgerald, Rohit Bose, Jonathan Chou, Terence W. Friedlander, Vadim S Koshkin, Lawrence Fong, Maya Aslam, Khadija Siddiqua, Eric J. Small, Bin Liu, Robert R. Flavell, Rahul Raj Aggarwal. Journal of Clinical Oncology . Jan 1, 2024 Development of CD46 Targeted Alpha Theranostics in Prostate Cancer using134Ce/225Ac-Macropa-PEG4-YS5 Kondapa Naidu Bobba, Anil P. Bidkar, Anju Wadhwa, Niranjan Meher, Suchi Drona, Alexandre M. Sorlin, Scott Bidlingmaier, Li Zhang, David M. Wilson, Emily Chan, Nancy Y. Greenland, Rahul Aggarwal, Henry F. VanBrocklin, Jiang He, Jonathan Chou, Youngho Seo, Bin Liu, Robert R. Flavell. Theranostics . Jan 1, 2024 CD46-targeted theranostics for Positron Emission Tomography and 225Ac-radiopharmaceutical Therapy of Multiple Myeloma Anju Wadhwa, Sinan Wang, Bonell Patino Escobar, Anil P. Bidkar, Kondapa Naidu Bobba, Emily Chan, Niranjan Meher, Scott Bidlingmaier, Yang Su, Suchi Drona, Huimin Geng, Vishesh Sarin, Henry F. VanBrocklin, David M. Wilson, Jiang He, Li Zhang, Veronica Steri, Sandy Wong, Tom Martin, Youngho Seo, Bin Liu, Arun P. Wiita, Robert R. Flavell. 2023 Dec 18. PMID: 38109209 PMCID: PMC10905524. doi: 10.1158/1078-0432.CCR-23-2130. Clin Cancer Res. . Dec 18, 2023 CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts Michael J. VanWyngarden, Zachary J. Walker, Yang Su, Olivia Perez de Acha, Brett M. Stevens, Peter A. Forsberg, Tomer M. Mark, William Matsui, Bin Liu*, Daniel W. Sherbenou*. (*co-senior authors) Cancers . Nov 9, 2023 CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment. Li J, Huang T, Hua J, Wang Q, Su Y, Chen P, Bidlingmaier S, Li A, Xie Z, Bidkar AP, Shen S, Shi W, Seo Y, Flavell RR, Gioeli D, Dreicer R, Li H, Liu B, He J Journal of experimental & clinical cancer research : CR . Mar 11, 2023 CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment Jun Li, Tao Huang, Jun Hua, Qiong Wang, Yang Su, Ping Chen, Scott Bidlingmaier, Allan Li, Zhongqiu Xie, Anil Bidkar, Sui Shen, Weibin Shi, Youngho Seo, Robert R. Flavell, Daniel Gioeli, Robert Dreicer, Hui Li, Bin Liu*, Jiang He*. (*co-senior authors) J Exp. Clin. Cancer Res. . Jan 1, 2023 Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225 Ac a-Radiotherapeutics Kondapa Naidu Bobba, Anil P Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin, Robert R. Flavell. J Nucl Med. . Jan 1, 2023 Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies Zhu, I., Liu, R., Garcia, J.M., Hyrenius-Wittsten, A., Piraner, D., Alavi, J., Israni, D.V., Liu, B., Khalil, A.S., Roybal, K.T. Cell . Jan 1, 2022 Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC) Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J. Journal of Clinical Oncology . Jan 1, 2022 Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC) Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J. Journal of Clinical Oncology . Jan 1, 2022 Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J.M., Perry, N., Montgomery, G., Liu, B*., Roybal, K.T* Science Translational Medicine . Apr 28, 2021 SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT Science Translational Medicine . Apr 28, 2021 A first-in-human study of FOR46 in men with metastatic castration resistant prostate cancer (mCRPC) R.R. Aggarwal, J. Vuky, D. VanderWeele, M. Rettig, E. Heath, M. Nasoff, A. Dorr, B. Liu, E.J. Small. Annals of Oncology. . Jan 1, 2021 Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET. Wang S, Li J, Hua J, Su Y, Beckford-Vera DR, Zhao W, Jayaraman M, Huynh TL, Zhao N, Wang YH, Huang Y, Qin F, Shen S, Gioeli D, Dreicer R, Sriram R, Egusa EA, Chou J, Feng FY, Aggarwal R, Evans MJ, Seo Y, Liu B, Flavell RR, He J Clinical cancer research : an official journal of the American Association for Cancer Research . Dec 8, 2020 Molecular imaging of prostate cancer targeting CD46 using immunoPET Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D., Zhao, W., Jayaraman, M., Huynh, T.L., Zhao, N., Wang, Y.H., Huang, Y., Qin, F., Shen, S., Gioeli, D., Dreicer, R., Sriram, R., Egusa, E.A., Chou, J., Feng, F., Aggarwal, R., Evans, M.J., Seo, Y., Liu, B.*, Flavell, R.R.*, He, J.* Clinical Cancer Res . Dec 8, 2020 Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma Sherbenou, D.W., Su, Y., Behrens, C.R., Aftab, B.T., Perez de Acha, O., Murnane, M., Bearrows, S.C., Hann, B.C., Wolf, J.L., Martin, T.G., and Liu, B. Clinical Cancer Res . Nov 15, 2020 ALPPL2 is a highly specific and targetable tumor cell surface antigen Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B. Cancer Res . Oct 15, 2020 Potent Activity of an Anti-ICAM1 Antibody-Drug Conjugate against Multiple Myeloma. Sherbenou DW, Su Y, Behrens CR, Aftab BT, Perez de Acha O, Murnane M, Bearrows SC, Hann BC, Wolf JL, Martin TG, Liu B Clinical cancer research : an official journal of the American Association for Cancer Research . Sep 11, 2020 ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Su Y, Zhang X, Bidlingmaier S, Behrens CR, Lee NK, Liu B Cancer research . Aug 31, 2020 Quantitative (99m)Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma He, J., Feng, J., Su, Y., Seo, Y., and Liu, B. Bioconjug Chem. . Jul 15, 2020 LegoBody: facile generation of bispecific and multi-specific antibodies Lang, S., Yang, S., Bidlingmaier, S., Lee, N-K., Liu, B. bioRxiv . Jan 1, 2020 Manipulation of Cell-Type Selective Antibody Internalization by a Guide-Effector Bispecific Design. Lee NK, Su Y, Bidlingmaier S, Liu B Molecular cancer therapeutics . Apr 8, 2019 Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design Lee, N.K., Su, Y., Bidlingmaier, S., and Liu, B. Mol Cancer Ther. . Apr 8, 2019 Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer Su, Y., Liu, Y., Behrens, C.R., Bidlingmaier, S., Lee, N.K., Aggarwal, R., Sherbenou, D.W., Burlingame, A.L., Hann, B.C., Simko, J.P., Premasekharan, G., Paris, P.L., Shuman, M.A., Seo, Y., Small, E.J., and Liu, B. JCI Insight . Sep 6, 2018 Cell-type specific potent Wnt signaling blockade by bispecific antibody Lee, N.K., Zhang, Y., Su, Y., Bidlingmaier, S., Sherbenou, D.W., Ha, K.D., Liu, B. Sci Rep. . Jan 15, 2018 Cell-type specific potent Wnt signaling blockade by bispecific antibody. Lee NK, Zhang Y, Su Y, Bidlingmaier S, Sherbenou DW, Ha KD, Liu B Scientific reports . Jan 15, 2018 Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens Su, Y., Bidlingmaier, S., Lee, N.K., Liu, B. Methods Mol Biol. . Jan 1, 2018 Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens. Su Y, Bidlingmaier S, Lee NK, Liu B Methods in molecular biology (Clifton, N.J.) . Jan 1, 2018 Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes Lee, N.K., Bidlingmaier, S., Su, Y., Liu, B. Methods Mol Biol. . Jan 1, 2018 Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes. Lee NK, Bidlingmaier S, Su Y, Liu B Methods in molecular biology (Clifton, N.J.) . Jan 1, 2018 Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B. Methods Enzymol. . Jan 1, 2017 Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis. Ha KD, Bidlingmaier SM, Su Y, Lee NK, Liu B Methods in enzymology . Dec 1, 2016 Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells Sherbenou, D.W., Aftab, B.T., Su, Y., Behrens, C.R., Wiita, A., Logan, A.C., Acosta-Alvear, D., Hann, B.C., Walter, P., Shuman, M.A., Wu, X., Atkinson, J.P., Wolf, J.L., Martin, T.G., Liu, B. J Clin Invest. . Nov 14, 2016 Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing. Bidlingmaier S, Ha K, Lee NK, Su Y, Liu B Molecular & cellular proteomics : MCP . Jan 4, 2016 Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing Bidlingmaier, S., Ha, K., Lee, N.K., Su, Y., Liu, B. Mol Cell Proteomics. . Jan 4, 2016 Macropinocytosis exploitation by cancers and cancer therapy Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B. Frontier Physiology . Jan 1, 2016 Combining phage and yeast cell surface antibody display to identify novel cell type-selective internalizing human monoclonal antibodies Bidlingmaier, S., Liu, B. Methods Mol Biol. . Jan 1, 2015 Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries Bidlingmaier, S., Su, Y., and Liu, B. Methods Mol Biol. . Jan 1, 2015 Identification of novel protein-ligand interactions by exon microarray analysis of yeast surface displayed cDNA library selection outputs Bidlingmaier, S., Liu, B. Methods Mol Biol. . Jan 1, 2015 The Development of Potential Antibody-Based Therapies for Multiple Myeloma Sherbenou, D.W., Behrens, C.R. Yang Su, Wolf, J.L., Martin III, T.G., and Liu, B. Blood Rev. . Jan 1, 2015 Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions Bidlingmaier, S. and Liu, B. Methods Mol Biol. . Jan 1, 2015 Methods for site-specific drug conjugation to antibodies. Behrens CR, Liu B mAbs . Jan 1, 2014 Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT Sarcoma . Sep 11, 2012 An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM Molecular imaging and biology . Jun 1, 2012 Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J Cancer research . Mar 29, 2011 The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J Biomaterials . Jan 20, 2011 Construction of yeast surface-displayed cDNA libraries. Bidlingmaier S, Liu B Methods in molecular biology (Clifton, N.J.) . Jan 1, 2011 Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Bidlingmaier S, Liu B Methods in molecular biology (Clifton, N.J.) . Jan 1, 2011 Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B Molecular & cellular proteomics : MCP . Dec 2, 2010 Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Chen Y, Zhu X, Zhang X, Liu B, Huang L Molecular therapy : the journal of the American Society of Gene Therapy . Jul 6, 2010 Identification of internalizing human single antibodies targeting brain tumor stem cells Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S., and Liu, B. Mol Cancer Ther. . Jan 1, 2010 Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B. J Nucl Med. . Jan 1, 2010 Development of a highly stable and targetable nanoliposomal formulation of topotecan. Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB Journal of controlled release : official journal of the Controlled Release Society . Aug 15, 2009 Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B Cancer research . Feb 3, 2009 Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B. J Mol Med. . Jan 1, 2009 Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B. Mol Cancer Ther . Jan 1, 2008 The utility and limitation of CD133 epitopes in defining tumor stem cell population Bidlingmaier, S., Zhu, X., and Liu, B. J Mol Med. . Jan 1, 2008 Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA Molecular immunology . May 10, 2007 Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells Roth, A, Conrad, F., Hayes, M., Drummond, D.C., Kirpotin, D.B., Benz, C.C., Marks, J.D., and Liu, B. Mol Cancer Ther . Jan 1, 2007 Explore Cell Type-Specific Internalizing Antibodies For Targeted siRNA Delivery Liu, B. Brief Funct Genomic Proteomic . Jan 1, 2007 Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins Bidlingmaier, S and Liu, B. Mol Cell Proteomics . Jan 1, 2007 Prostate cancer targeting recombinant human IgG1s Liu, B., Conrad, F., Roth, A., Drummond, D.C and Marks, J.D. J Mol Med . Jan 1, 2007 Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions Bidlingmaier, S. and Liu, B. Mol Cell Proteomics . Jan 1, 2006 Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection Ruan, W., Sassoon, A., An, F., Simko, J.P., Liu, B. Mol Cell Proteomics . Jan 1, 2006 Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D. Cancer Res . Jan 1, 2004 Towards proteome-wide production of monoclonal antibody by phage display Liu, B., Huang, L., Burlingame, A.L., Marks, J.D. J Mol Biol . Jan 1, 2002 Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Liu B, Marks JD Analytical biochemistry . Nov 1, 2000 Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Liu B, Alberts BM Science (New York, N.Y.) . Feb 24, 1995 Organizational change as human process, not technique. Diamond MA NIDA research monograph . Jan 1, 1995 A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Liu B, Wong ML, Alberts B Proceedings of the National Academy of Sciences of the United States of America . Oct 25, 1994 The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM Nature . Nov 4, 1993
