Bin Liu, PhD

Bin Liu, PhD

Professor

Education

Ph.D., 1994 - Biochemistry & Biophysics, University of California
B.A., 1990 - Molecular Biology, Princeton University

Publications

Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies

Zhu, I., Liu, R., Garcia, J.M., Hyrenius-Wittsten, A., Piraner, D., Alavi, J., Israni, D.V., Liu, B., Khalil, A.S., Roybal, K.T.

Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC)

Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J.

Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits

Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J.M., Perry, N., Montgomery, G., Liu, B*., Roybal, K.T*

Molecular imaging of prostate cancer targeting CD46 using immunoPET

Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D., Zhao, W., Jayaraman, M., Huynh, T.L., Zhao, N., Wang, Y.H., Huang, Y., Qin, F., Shen, S., Gioeli, D., Dreicer, R., Sriram, R., Egusa, E.A., Chou, J., Feng, F., Aggarwal, R., Evans, M.J., Seo, Y., Liu, B.*, Flavell, R.R.*, He, J.*

Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma

Sherbenou, D.W., Su, Y., Behrens, C.R., Aftab, B.T., Perez de Acha, O., Murnane, M., Bearrows, S.C., Hann, B.C., Wolf, J.L., Martin, T.G., and Liu, B.

ALPPL2 is a highly specific and targetable tumor cell surface antigen

Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B.

Quantitative (99m)Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma

He, J., Feng, J., Su, Y., Seo, Y., and Liu, B.

Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design

Lee, N.K., Su, Y., Bidlingmaier, S., and Liu, B.

Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer

Su, Y., Liu, Y., Behrens, C.R., Bidlingmaier, S., Lee, N.K., Aggarwal, R., Sherbenou, D.W., Burlingame, A.L., Hann, B.C., Simko, J.P., Premasekharan, G., Paris, P.L., Shuman, M.A., Seo, Y., Small, E.J., and Liu, B.

Cell-type specific potent Wnt signaling blockade by bispecific antibody

Lee, N.K., Zhang, Y., Su, Y., Bidlingmaier, S., Sherbenou, D.W., Ha, K.D., Liu, B.

Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens

Su, Y., Bidlingmaier, S., Lee, N.K., Liu, B.

Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes

Lee, N.K., Bidlingmaier, S., Su, Y., Liu, B.

Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis

Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells

Sherbenou, D.W., Aftab, B.T., Su, Y., Behrens, C.R., Wiita, A., Logan, A.C., Acosta-Alvear, D., Hann, B.C., Walter, P., Shuman, M.A., Wu, X., Atkinson, J.P., Wolf, J.L., Martin, T.G., Liu, B.

Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing

Bidlingmaier, S., Ha, K., Lee, N.K., Su, Y., Liu, B.

Macropinocytosis exploitation by cancers and cancer therapy

Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.

Combining phage and yeast cell surface antibody display to identify novel cell type-selective internalizing human monoclonal antibodies

Bidlingmaier, S., Liu, B.

Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries

Bidlingmaier, S., Su, Y., and Liu, B.

Identification of novel protein-ligand interactions by exon microarray analysis of yeast surface displayed cDNA library selection outputs

Bidlingmaier, S., Liu, B.

The Development of Potential Antibody-Based Therapies for Multiple Myeloma

Sherbenou, D.W., Behrens, C.R. Yang Su, Wolf, J.L., Martin III, T.G., and Liu, B.

Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions

Bidlingmaier, S. and Liu, B.

Methods for site-specific drug conjugation to antibodies.

Behrens CR, Liu B

Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor.

Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT

An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors.

McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM

Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas.

Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J

The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma.

Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J

Construction of yeast surface-displayed cDNA libraries.

Bidlingmaier S, Liu B

Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries.

Bidlingmaier S, Liu B

Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions.

Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B

Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.

Chen Y, Zhu X, Zhang X, Liu B, Huang L

Identification of internalizing human single antibodies targeting brain tumor stem cells

Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S., and Liu, B.

Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment

He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B.

Development of a highly stable and targetable nanoliposomal formulation of topotecan.

Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB

Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma.

Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B

Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion

Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B.

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies

An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B.

The utility and limitation of CD133 epitopes in defining tumor stem cell population

Bidlingmaier, S., Zhu, X., and Liu, B.

Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.

Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA

Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells

Roth, A, Conrad, F., Hayes, M., Drummond, D.C., Kirpotin, D.B., Benz, C.C., Marks, J.D., and Liu, B.

Explore Cell Type-Specific Internalizing Antibodies For Targeted siRNA Delivery

Liu, B.

Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins

Bidlingmaier, S and Liu, B.

Prostate cancer targeting recombinant human IgG1s

Liu, B., Conrad, F., Roth, A., Drummond, D.C and Marks, J.D.

Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions

Bidlingmaier, S. and Liu, B.

Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection

Ruan, W., Sassoon, A., An, F., Simko, J.P., Liu, B.

Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells

Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D.

Towards proteome-wide production of monoclonal antibody by phage display

Liu, B., Huang, L., Burlingame, A.L., Marks, J.D.

Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose.

Liu B, Marks JD

Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex.

Liu B, Alberts BM

Organizational change as human process, not technique.

Diamond MA

A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain.

Liu B, Wong ML, Alberts B

The DNA replication fork can pass RNA polymerase without displacing the nascent transcript.

Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM