Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Research Specialties Trauma Education 07/2011 - Post-doctoral Fellowship/Clinical Instructor, University of California San Francisco07/2009 - Anesthesiology, University of California San Francisco06/2006 - Internship in Internal Medicine, Santa Clara Valley Medical CenterMD/PhD, 06/2005 - Medicine/Immunology, New York University School of MedicineBachelors of Science/Arts, 06/1996 - Chemistry/History, University of Rochester Publications Gut microbiome-derived propionate reprograms alveolar macrophages metabolically and regulates lung injury responses in mice. Maruyama D, Tian X, Doan TNM, Liao WI, Chaki T, Taenaka H, Maishan M, Matthay MA, Prakash A Gut microbes . Dec 30, 2025 Gut Microbiota-Derived Lipopolysaccharides and Short-Chain Fatty Acids Regulate Immune Responses via FFAR2/FFAR3 in Lung Ischemia-Reperfusion Injury. Maruyama D, Doan TNM, Tian X, Chaki T, Yeh JJ, Layden BT, Prakash A Annals of the New York Academy of Sciences . Oct 1, 2025 Sequential Blood Collection from Inferior Vena Cava Followed by Portal Vein to Evaluate Gut Microbial Metabolites in Mice. Doan TNM, Maruyama D, Tian X, Prakash A Journal of visualized experiments : JoVE . Jun 21, 2024 Regulation of Lung Immune Tone by the Gut-Lung Axis via Dietary Fiber, Gut Microbiota, and Short-Chain Fatty Acids. Maruyama D, Liao WI, Tian X, Bredon M, Knapp J, Tat C, Doan TNM, Chassaing B, Bhargava A, Sokol H, Prakash A bioRxiv : the preprint server for biology . Aug 25, 2023 A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery. Liao WI, Maruyama D, Kianian F, Tat C, Tian X, Hellman J, Dodd-O JM, Prakash A Journal of visualized experiments : JoVE . Sep 9, 2022 Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression. Liu Q, Tian X, Maruyama D, Arjomandi M, Prakash A American journal of physiology. Lung cellular and molecular physiology . Apr 14, 2021 Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples. Lee W, Straube S, Sincic R, Noble JA, Montoy JC, Kornblith AE, Prakash A, Wang R, Bainton RJ, Kurien PA medRxiv : the preprint server for health sciences . Dec 4, 2020 A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology. Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ The journal of trauma and acute care surgery . Jun 1, 2020 Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A Frontiers in microbiology . Feb 14, 2019 NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A Frontiers in immunology . Oct 31, 2017 N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K Journal of immunology (Baltimore, Md. : 1950) . Jul 12, 2017 Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J Shock (Augusta, Ga.) . Sep 1, 2015 Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J Science signaling . Aug 25, 2015 Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS American journal of physiology. Lung cellular and molecular physiology . Mar 20, 2015 Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles. Zhang N, Francis KP, Prakash A, Ansaldi D Nature Medicine . Mar 3, 2013 Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J Anesthesiology . Oct 1, 2012 Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J Innate immunity . Dec 20, 2011 Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J Journal of immunology (Baltimore, Md. : 1950) . Dec 17, 2010 Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. Prakash A, Hellman J Journal of leukocyte biology . Oct 1, 2010 Regulation of IRF7 through cell type-specific protein stability. Prakash A, Levy DE Biochemical and biophysical research communications . Feb 3, 2006 Tissue-specific positive feedback requirements for production of type I interferon following virus infection. Prakash A, Smith E, Lee CK, Levy DE The Journal of biological chemistry . Mar 14, 2005 Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Levy DE, Marié I, Prakash A Current opinion in immunology . Feb 1, 2003 Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I The Journal of biological chemistry . Oct 8, 2002 Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. Levy DE, Marié I, Smith E, Prakash A Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research . Jan 1, 2002 IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE The Journal of biological chemistry . Dec 21, 2000 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Marié I, Smith E, Prakash A, Levy DE Molecular and cellular biology . Dec 1, 2000
