Biography I am an anesthesiologist specializing in the care of neurosurgical and obstetric patients. Additionally, I am also a physician-scientist studying how neural circuits and molecular mechanisms regulate anesthesia-related consciousness. My research focuses on the hypothalamic orexin/hypocretin system, using chemogenetics, optogenetics, and in vivo imaging to dissect how specific brain pathways influence anesthesia depth and recovery. In parallel, I am developing a clinical strategy to facilitate the reversal of general anesthesia. With a background in molecular biology, electrophysiology, and clinical anesthesiology, I am committed to bridging basic neuroscience with real-world anesthetic care, aiming to develop mechanistic insights and innovative tools that improve perioperative outcomes. Role Faculty Location UCSF at Mission Bay UCSF at Mount Zion UCSF at Parnassus Category Clinical Research Specialties Neuroanesthesia Education M.D., - Medicine, Hebei Medical UniversityM.S., - Genetics, Peking Union Medical CollegePh.D., - Biology, University of California, San DiegoResidency, - Anesthesia and Perioperative Care, University of California, San Francisco Publications Orexinergic projections to substantia innominata mediate arousal and analgesia. Xiang X, Wang F, Chen C, Guan Z, Zhou W British journal of anaesthesia . Jul 8, 2025 Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control. Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W Frontiers in cellular neuroscience . Apr 26, 2022 Ion Channels in Anesthesia. Zhou W, Guan Z Advances in experimental medicine and biology . Jan 1, 2021 Activation of orexin system facilitates anesthesia emergence and pain control. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY Proceedings of the National Academy of Sciences of the United States of America . Oct 22, 2018 A twist on potassium channel gating. Zhou W, Jan L Cell . Jun 11, 2010 The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Gu C, Zhou W, Puthenveedu MA, Xu M, Jan YN, Jan LY Neuron . Dec 7, 2006 Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S Nature neuroscience . Feb 20, 2005 Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S Neuron . Feb 19, 2004 Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Nanao MH, Zhou W, Pfaffinger PJ, Choe S Proceedings of the National Academy of Sciences of the United States of America . Jun 30, 2003 Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Zhou W, Arrabit C, Choe S, Slesinger PA Proceedings of the National Academy of Sciences of the United States of America . May 15, 2001