Richard Weiskopf, MD

Professor Emeritus

Publications: 
Weiskopf RB, Davenport R, Cap AP, Reddy V, Waters JH, Cserti-Gazdewich C. Increasing hemoglobin concentration with an artificial oxygen carrier improves severe anemia-induced degraded cognitive function. J Trauma Acute Care Surg. 2021 08 01; 91(2S Suppl 2):S182-S185.
Weiskopf RB, Cook RJ. Known and Unknown Unknowns in Making Erythrocyte Transfusion Decisions. Anesthesiology. 2021 03 01; 134(3):359-362.
Weiskopf RB, Glassberg E, Guinn NR, James MFM, Ness PM, Pusateri AE. The need for an artificial oxygen carrier for disasters and pandemics, including COVID-19. Transfusion. 2020 12; 60(12):3039-3045.
Guinn NR, Cooter ML, Weiskopf RB. Lower hemoglobin concentration decreases time to death in severely anemic patients for whom blood transfusion is not an option. J Trauma Acute Care Surg. 2020 06; 88(6):803-808.
Hill-Pryor C, Pusateri AE, Weiskopf RB. Hemoglobin-based Oxygen Carriers (HBOC)-What the Next Generation Holds: When Red Blood Cells are not an Option. Shock. 2019 10; 52(1S Suppl 1):4-6.
Pusateri AE, Glassberg E, Weiskopf RB. Reassessment of the Need for an Oxygen Carrier for the Treatment of Traumatic Hemorrhage When Blood is not an Option. Shock. 2019 10; 52(1S Suppl 1):55-59.
Pusateri AE, Butler FK, Shackelford SA, Sperry JL, Moore EE, Cap AP, Taylor AL, Homer MJ, Hoots WK, Weiskopf RB, Davis MR. The need for dried plasma - a national issue. Transfusion. 2019 04; 59(S2):1587-1592.
Cook RJ, Weiskopf RB. Observing Blood Management Programs through the Retrospectroscope. Anesthesiology. 2018 12; 129(6):1060-1062.
Guinn NR, Cooter ML, Villalpando C, Weiskopf RB. Severe anemia associated with increased risk of death and myocardial ischemia in patients declining blood transfusion. Transfusion. 2018 10; 58(10):2290-2296.
Weiskopf RB, Cook RJ. Demonstrating therapeutic equivalence of a new and established pharmaceutical or intervention: a guide for the non-statistician. Transfusion. 2017 06; 57(6):1343-1346.
Feiner JR, Weiskopf RB. Evaluating Pulmonary Function: An Assessment of PaO2/FIO2. Crit Care Med. 2017 Jan; 45(1):e40-e48.
Weiskopf RB, Beliaev AM, Shander A, Guinn NR, Cap AP, Ness PM, Silverman TA. Addressing the unmet need of life-threatening anemia with hemoglobin-based oxygen carriers. Transfusion. 2017 01; 57(1):207-214.
Weiskopf RB, Cook RJ. Understanding non-inferiority trials and tests for the non-statistician: when to use them and how to interpret them. Transfusion. 2017 02; 57(2):240-243.
Weiskopf RB. What is innovation? Transfusion. 2016 Mar; 56 Suppl 1:S3-5.
Weiskopf RB. Lack of Nephrotoxicity of Hydroxyethyl Starch 130/0.4 When Used in Surgery. Anesthesiology. 2015 Aug; 123(2):482-3.
Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB. A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology. 2015 Jul; 123(1):126-35.
Weiskopf RB, James MF. Update of use of hydroxyethyl starches in surgery and trauma. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S54-9.
Weiskopf RB. Hemoglobin-based oxygen carriers: disclosed history and the way ahead: the relativity of safety. Anesth Analg. 2014 Oct; 119(4):758-760.
Weiskopf RB. Hydroxyethyl starches: a tale of two contexts: the problem of knowledge. Anesth Analg. 2014 Sep; 119(3):509-513.
Weiskopf RB. The efficacy and safety of liquid stored blood and storage duration: a confused subject; are patients confused? Anesth Analg. 2014 Aug; 119(2):224-229.
Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock. 2014 May; 41 Suppl 1:3-12.
Butler FK, Holcomb JB, Schreiber MA, Kotwal RS, Jenkins DA, Champion HR, Bowling F, Cap AP, Dubose JJ, Dorlac WC, Dorlac GR, McSwain NE, Timby JW, Blackbourne LH, Stockinger ZT, Strandenes G, Weiskopf RB, Gross KR, Bailey JA. Fluid Resuscitation for Hemorrhagic Shock in Tactical Combat Casualty Care: TCCC Guidelines Change 14-01--2 June 2014. J Spec Oper Med. 2014; 14(3):13-38.
Weiskopf RB. Equivalent efficacy of hydroxyethyl starch 130/0.4 and human serum albumin: if nothing is the same, is everything different? The importance of context in clinical trials and statistics. Anesthesiology. 2013 Dec; 119(6):1249-54.
Van Der Linden P, James M, Mythen M, Weiskopf RB. In response. Anesth Analg. 2013 Aug; 117(2):530-1.
Weiskopf RB, Silverman TA. Balancing potential risks and benefits of hemoglobin-based oxygen carriers. Transfusion. 2013 Oct; 53(10):2327-33.
Pusateri AE, Weiskopf RB, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, Hansen DR, Hoots WK, Klein HG, Macdonald VW, Mattox KL, Michael RA, Mogford J, Montcalm-Smith EA, Niemeyer DM, Prusaczyk WK, Rappold JF, Rassmussen T, Rentas F, Ross J, Thompson C, Tucker LD, US DoD Hemorrhage and Resuscitation Research and Development Steering Committee. Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock. 2013 Feb; 39(2):121-6.
Weiskopf RB, Ness PM. Transfusion for remote damage control resuscitation. Transfusion. 2013 Jan; 53 Suppl 1:1S-5S.
Weiskopf RB, Ness PM. Transfusion for remote damage control resuscitation. Transfusion. 2013 Jan; 53(1):8-12.
Van Der Linden P, James M, Mythen M, Weiskopf RB. Safety of modern starches used during surgery. Anesth Analg. 2013 Jan; 116(1):35-48.
Rollins MD, Molofsky AB, Nambiar A, Pandey S, Weiskopf RB, Toy P. Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Crit Care Med. 2012 Aug; 40(8):2488-91.
Weiskopf RB. Reconstructing deconstructed blood for trauma. Anesthesiology. 2012 Mar; 116(3):518-21.
Weiskopf RB. From life-blood streaming to hemostasis. Anesth Analg. 2012 Feb; 114(2):247-9.
Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O. Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):842-50.
Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9.
Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67.
Feiner JR, Finlay-Morreale HE, Toy P, Lieberman JA, Viele MK, Hopf HW, Weiskopf RB. High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. Anesthesiology. 2011 Sep; 115(3):492-8.
Weiskopf RB. Blood samples, repositories, and ethics. Transfusion. 2011 May; 51(5):1123-5; author reply 1125.
Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Bulger E, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, MacKenzie E, McGinnis RL, Michalek J, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock. 2011 Feb; 35(2):107-13.
Weiskopf RB. Emergency transfusion for acute severe anemia: a calculated risk. Anesth Analg. 2010 Nov; 111(5):1088-92.
Weiskopf RB. Conflicts of interest in expert-authored practice parameters, standards, guidelines, recommendations. Anesthesiology. 2010 Sep; 113(3):751-2; author reply 752-3.
Weiskopf RB. Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials. Anesth Analg. 2010 Mar 01; 110(3):659-62.
Weiskopf RB. Perioperative use of beta-adrenergic antagonists and anemia: known knowns, known unknowns, unknown unknowns; and Unknown Knowns. Anesthesiology. 2010 Jan; 112(1):12-5.
Weiskopf RB. Hemostasis in trauma. Transfusion. 2009 Dec; 49 Suppl 5:237S-9S.
Silverman TA, Weiskopf RB, Planning Committee and the Speakers. Hemoglobin-based oxygen carriers: current status and future directions. Anesthesiology. 2009 Nov; 111(5):946-63.
Silverman TA, Weiskopf RB. Hemoglobin-based oxygen carriers: current status and future directions. Transfusion. 2009 Nov; 49(11):2495-515.
Weiskopf RB. Prospective randomized clinical transfusion trials and statistical analysis. Transfusion. 2009 Aug; 49(8):1770; author reply 1770-1.
Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75.
Weiskopf RB, Feiner J, Toy P. Red blood cell age and function. Transfusion. 2008 Sep; 48(9):2026.
Weiskopf RB, Feiner J, Lieberman J, Hu SS. Visual loss after spinal surgery. Anesthesiology. 2007 Jun; 106(6):1250-1; author reply 1251-2.
Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE, Prough DS, Baus D, Bepperling F, Warltier DC. Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch. Anesthesiology. 2007 Jun; 106(6):1120-7.
Weiskopf RB, Novo Nordisk. Food and Drug Administration public hearing on the draft guidance for exception from informed consent requirements for emergency research: testimony of Novo Nordisk. Acad Emerg Med. 2007 Apr; 14(4):e71-3.
Champion HR, Fingerhut A, Escobar MA, Weiskopf RB. The role of data and safety monitoring in acute trauma resuscitation research. J Am Coll Surg. 2007 Jan; 204(1):73-83.
Weiskopf RB. If you prick us, do we not bleed? Anesthesiology. 2006 Nov; 105(5):873-6.
Madjdpour C, Spahn DR, Weiskopf RB. Anemia and perioperative red blood cell transfusion: a matter of tolerance. Crit Care Med. 2006 May; 34(5 Suppl):S102-8.
Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P. Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Anesthesiology. 2006 May; 104(5):911-20.
Weiskopf RB, Schnapp S, Rouine-Rapp K, Bostrom A, Toy P. Extracellular potassium concentrations in red blood cell suspensions after irradiation and washing. Transfusion. 2005 Aug; 45(8):1295-301.
Hardy JF, Weiskopf RB. Choosing the optimal endpoint(s) for a clinical trial on transfusion. Transfusion. 2005 Jul; 45(1 Suppl):1S.
Weiskopf RB, Webb M, Stangle D, Klinbergs G, Toy P. A procedure for rapid issue of red cells for emergency use. Arch Pathol Lab Med. 2005 Apr; 129(4):492-6.
Neumann MA, Eger EI, Weiskopf RB. Solubility of volatile anesthetics in bovine white matter, cortical gray matter, thalamus, hippocampus, and hypothalamic area. Anesth Analg. 2005 Apr; 100(4):1003-1006.
Weiskopf RB, Toy P, Hopf HW, Feiner J, Finlay HE, Takahashi M, Bostrom A, Songster C, Aminoff MJ. Acute isovolemic anemia impairs central processing as determined by P300 latency. Clin Neurophysiol. 2005 May; 116(5):1028-32.
Szpalski M, Gunzburg R, Aebi M, Weiskopf R. Research and evidence about blood sparing in spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S1-2.
Weiskopf RB. The use of recombinant activated coagulation factor VII for spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S83-8.
Weiskopf RB, Aminoff MJ, Hopf HW, Feiner J, Viele MK, Watson JJ, Ho R, Songster C, Toy P. Acute isovolemic anemia does not impair peripheral or central nerve conduction. Anesthesiology. 2003 Sep; 99(3):546-51.
Fléron MH, Weiskopf RB, Bertrand M, Mouren S, Eyraud D, Godet G, Riou B, Kieffer E, Coriat P. A comparison of intrathecal opioid and intravenous analgesia for the incidence of cardiovascular, respiratory, and renal complications after abdominal aortic surgery. Anesth Analg. 2003 Jul; 97(1):2-12, table of contents.
Weiskopf RB, Feiner J, Hopf H, Viele MK, Watson JJ, Lieberman J, Kelley S, Toy P. Heart rate increases linearly in response to acute isovolemic anemia. Transfusion. 2003 Feb; 43(2):235-40.
Weiskopf RB. Hemodilution and candles. Anesthesiology. 2002 Oct; 97(4):773-5.
Weiskopf RB. Intraoperative use of recombinant activated coagulation factor vII. Anesthesiology. 2002 Jun; 96(6):1287-9.
Weiskopf RB, Feiner J, Hopf HW, Viele MK, Watson JJ, Kramer JH, Ho R, Toy P. Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Anesthesiology. 2002 Apr; 96(4):871-7.