Role Faculty Category Clinical Publications Safety of Bioplasma FDP and Hemopure in rhesus macaques after 30% hemorrhage. Pusateri AE, Morgan CG, Neidert LE, Tiller MM, Glaser JJ, Weiskopf RB, Ebrahim I, Stassen W, Rambharose S, Mahoney SH, Wallis LA, Hollis EM, Delong GT, Cardin S The Effect of Prehospital Clinical Trial-Related Procedures on Scene Interval, Cognitive Load, and Error: A Randomized Simulation Study. Stassen W, Wylie C, Craig W, Ebrahim I, Mahoney SH, Pusateri AE, Rambharose S, van Koningsbruggen C, Weiskopf RB, Wallis LA Use of Dried Plasma in Prehospital and Austere Environments. Pusateri AE, Malloy WW, Sauer D, Benov A, Corley JB, Rambharose S, Wallis L, Tiller MM, Cardin S, Glassberg E, Weiskopf RB Increasing hemoglobin concentration with an artificial oxygen carrier improves severe anemia-induced degraded cognitive function. Weiskopf RB, Davenport R, Cap AP, Reddy V, Waters JH, Cserti-Gazdewich C Known and Unknown Unknowns in Making Erythrocyte Transfusion Decisions. Weiskopf RB, Cook RJ The need for an artificial oxygen carrier for disasters and pandemics, including COVID-19. Weiskopf RB, Glassberg E, Guinn NR, James MFM, Ness PM, Pusateri AE Lower hemoglobin concentration decreases time to death in severely anemic patients for whom blood transfusion is not an option. Guinn NR, Cooter ML, Weiskopf RB Hemoglobin-based Oxygen Carriers (HBOC)-What the Next Generation Holds: When Red Blood Cells are not an Option. Hill-Pryor C, Pusateri AE, Weiskopf RB Reassessment of the Need for an Oxygen Carrier for the Treatment of Traumatic Hemorrhage When Blood is not an Option. Pusateri AE, Glassberg E, Weiskopf RB The need for dried plasma - a national issue. Pusateri AE, Butler FK, Shackelford SA, Sperry JL, Moore EE, Cap AP, Taylor AL, Homer MJ, Hoots WK, Weiskopf RB, Davis MR Observing Blood Management Programs through the Retrospectroscope. Cook RJ, Weiskopf RB Severe anemia associated with increased risk of death and myocardial ischemia in patients declining blood transfusion. Guinn NR, Cooter ML, Villalpando C, Weiskopf RB Demonstrating therapeutic equivalence of a new and established pharmaceutical or intervention: a guide for the non-statistician. Weiskopf RB, Cook RJ Evaluating Pulmonary Function: An Assessment of PaO2/FIO2. Feiner JR, Weiskopf RB Addressing the unmet need of life-threatening anemia with hemoglobin-based oxygen carriers. Weiskopf RB, Beliaev AM, Shander A, Guinn NR, Cap AP, Ness PM, Silverman TA Understanding non-inferiority trials and tests for the non-statistician: when to use them and how to interpret them. Weiskopf RB, Cook RJ What is innovation? Weiskopf RB Lack of Nephrotoxicity of Hydroxyethyl Starch 130/0.4 When Used in Surgery. Weiskopf RB A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB Update of use of hydroxyethyl starches in surgery and trauma. Weiskopf RB, James MF Hemoglobin-based oxygen carriers: disclosed history and the way ahead: the relativity of safety. Weiskopf RB Hydroxyethyl starches: a tale of two contexts: the problem of knowledge. Weiskopf RB The efficacy and safety of liquid stored blood and storage duration: a confused subject; are patients confused? Weiskopf RB Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC Fluid Resuscitation for Hemorrhagic Shock in Tactical Combat Casualty Care: TCCC Guidelines Change 14-01--2 June 2014. Butler FK, Holcomb JB, Schreiber MA, Kotwal RS, Jenkins DA, Champion HR, Bowling F, Cap AP, DuBose JJ, Dorlac WC, Dorlac GR, McSwain NE, Timby JW, Blackbourne LH, Stockinger Z, Strandenes G, Weiskopf RB, Gross K, Bailey JA Equivalent efficacy of hydroxyethyl starch 130/0.4 and human serum albumin: if nothing is the same, is everything different? The importance of context in clinical trials and statistics. Weiskopf RB In response. Van Der Linden P, James M, Mythen M, Weiskopf RB Balancing potential risks and benefits of hemoglobin-based oxygen carriers. Weiskopf RB, Silverman TA Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Pusateri AE, Weiskopf RB, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, Hansen DR, Hoots WK, Klein HG, Macdonald VW, Mattox KL, Michael RA, Mogford J, Montcalm-Smith EA, Niemeyer DM, Prusaczyk WK, Rappold JF, Rassmussen T, Rentas F, Ross J, Thompson C, Tucker LD, US DoD Hemorrhage and Resuscitation Research and Development Steering Committee Transfusion for remote damage control resuscitation. Weiskopf RB, Ness PM Transfusion for remote damage control resuscitation. Weiskopf RB, Ness PM Safety of modern starches used during surgery. Van Der Linden P, James M, Mythen M, Weiskopf RB Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Rollins MD, Molofsky AB, Nambiar A, Pandey S, Weiskopf RB, Toy P Reconstructing deconstructed blood for trauma. Weiskopf RB From life-blood streaming to hemostasis. Weiskopf RB Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA Transfusion-related acute lung injury: incidence and risk factors. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. Feiner JR, Finlay-Morreale HE, Toy P, Lieberman JA, Viele MK, Hopf HW, Weiskopf RB Blood samples, repositories, and ethics. Weiskopf RB Challenges to effective research in acute trauma resuscitation: consent and endpoints. Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Bulger E, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, MacKenzie E, McGinnis RL, Michalek J, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE Emergency transfusion for acute severe anemia: a calculated risk. Weiskopf RB Conflicts of interest in expert-authored practice parameters, standards, guidelines, recommendations. Weiskopf RB Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials. Weiskopf RB Perioperative use of beta-adrenergic antagonists and anemia: known knowns, known unknowns, unknown unknowns; and Unknown Knowns. Weiskopf RB Hemostasis in trauma. Weiskopf RB Hemoglobin-based oxygen carriers: current status and future directions. Silverman TA, Weiskopf RB, Planning Committee and the Speakers Hemoglobin-based oxygen carriers: current status and future directions. Silverman TA, Weiskopf RB Prospective randomized clinical transfusion trials and statistical analysis. Weiskopf RB Microarray kit analysis of cytokines in blood product units and segments. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P Red blood cell age and function. Weiskopf RB, Feiner J, Toy P Visual loss after spinal surgery. Weiskopf RB, Feiner J, Lieberman J, Hu SS Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch. Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE, Prough DS, Baus D, Bepperling F, Warltier DC Recombinant-activated coagulation factor VIIa (NovoSeven): current development. Weiskopf RB Food and Drug Administration public hearing on the draft guidance for exception from informed consent requirements for emergency research: testimony of Novo Nordisk. Weiskopf RB, Novo Nordisk The role of data and safety monitoring in acute trauma resuscitation research. Champion HR, Fingerhut A, Escobar MA, Weiskopf RB If you prick us, do we not bleed? Weiskopf RB Anemia and perioperative red blood cell transfusion: a matter of tolerance. Madjdpour C, Spahn DR, Weiskopf RB Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P Extracellular potassium concentrations in red blood cell suspensions after irradiation and washing. Weiskopf RB, Schnapp S, Rouine-Rapp K, Bostrom A, Toy P Choosing the optimal endpoint(s) for a clinical trial on transfusion. Hardy JF, Weiskopf RB A procedure for rapid issue of red cells for emergency use. Weiskopf RB, Webb M, Stangle D, Klinbergs G, Toy P Solubility of volatile anesthetics in bovine white matter, cortical gray matter, thalamus, hippocampus, and hypothalamic area. Neumann MA, Eger EI, Weiskopf RB Acute isovolemic anemia impairs central processing as determined by P300 latency. Weiskopf RB, Toy P, Hopf HW, Feiner J, Finlay HE, Takahashi M, Bostrom A, Songster C, Aminoff MJ Research and evidence about blood sparing in spine surgery. Szpalski M, Gunzburg R, Aebi M, Weiskopf R The use of recombinant activated coagulation factor VII for spine surgery. Weiskopf RB Acute isovolemic anemia does not impair peripheral or central nerve conduction. Weiskopf RB, Aminoff MJ, Hopf HW, Feiner J, Viele MK, Watson JJ, Ho R, Songster C, Toy P A comparison of intrathecal opioid and intravenous analgesia for the incidence of cardiovascular, respiratory, and renal complications after abdominal aortic surgery. Fléron MH, Weiskopf RB, Bertrand M, Mouren S, Eyraud D, Godet G, Riou B, Kieffer E, Coriat P Heart rate increases linearly in response to acute isovolemic anemia. Weiskopf RB, Feiner J, Hopf H, Viele MK, Watson JJ, Lieberman J, Kelley S, Toy P Hemodilution and candles. Weiskopf RB Intraoperative use of recombinant activated coagulation factor vII. Weiskopf RB Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Weiskopf RB, Feiner J, Hopf HW, Viele MK, Watson JJ, Kramer JH, Ho R, Toy P Efficacy of acute normovolemic hemodilution assessed as a function of fraction of blood volume lost. Weiskopf RB Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P Acute severe isovolemic anemia impairs cognitive function and memory in humans. Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson JJ, Hopf HW, Toy P Erythrocyte salvage during cesarean section. Weiskopf RB Fatigue during acute isovolemic anemiain healthy, resting humans. Toy P, Feiner J, Viele MK, Watson J, Yeap H, Weiskopf RB Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1). Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M The elimination of sodium and potassium hydroxides from desiccated soda lime diminishes degradation of desflurane to carbon monoxide and sevoflurane to compound A but does not compromise carbon dioxide absorption. Neumann MA, Laster MJ, Weiskopf RB, Gong DH, Dudziak R, Förster H, Eger EI Red cell transfusion outcome studies require a prospective, randomized design. Weiskopf RB Do we know when to transfuse red cells to treat acute anemia? Weiskopf RB Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans. Neumann MA, Weiskopf RB, Gong DH, Eger EI, Ionescu P The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB Human cardiovascular and metabolic response to acute, severe isovolemic anemia. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl. Daniel M, Weiskopf RB, Noorani M, Eger EI In rats breathing from a nonrebreathing system, substitution of desflurane for isoflurane toward the end of anesthesia incompletely restores the time of recovery toward that of desflurane. Gong DH, Weiskopf RB, Neumann MA, Laster MJ, Eger EI Dehydration of Baralyme increases compound A resulting from sevoflurane degradation in a standard anesthetic circuit used to anesthetize swine. Steffey EP, Laster MJ, Ionescu P, Eger EI, Gong D, Weiskopf RB Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane. Eger EI, Ionescu P, Laster MJ, Gong D, Weiskopf RB, Kerschmann RL Baralyme dehydration increases and soda lime dehydration decreases the concentration of compound A resulting from sevoflurane degradation in a standard anesthetic circuit. Eger EI, Ionescu P, Laster MJ, Weiskopf RB Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products. Eger EI, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics. Viele MK, Weiskopf RB, Fisher D Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Eger EI, Koblin DD, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB Compound A: solubility in saline and olive oil; destruction by blood. Eger EI, Ionescu P, Koblin DD, Weiskopf RB Propofol fails to attenuate the cardiovascular response to rapid increases in desflurane concentration. Daniel M, Eger EI, Weiskopf RB, Noorani M Cardiovascular stimulation induced by rapid increases in desflurane concentration in humans results from activation of tracheopulmonary and systemic receptors. Weiskopf RB, Eger EI, Daniel M, Noorani M Fentanyl, clonidine, and repeated increases in desflurane concentration, but not nitrous oxide or esmolol, block the transient mydriasis caused by rapid increases in desflurane concentration. Daniel M, Larson MD, Eger EI, Noorani M, Weiskopf RB Subanesthetic concentrations of desflurane and isoflurane suppress explicit and implicit learning. Gonsowski CT, Chortkoff BS, Eger EI, Bennett HL, Weiskopf RB Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion. Weiskopf RB Fentanyl, esmolol, and clonidine blunt the transient cardiovascular stimulation induced by desflurane in humans. Weiskopf RB, Eger EI, Noorani M, Daniel M Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans. Weiskopf RB, Eger EI, Noorani M, Daniel M Rapid 1% increases of end-tidal desflurane concentration to greater than 5% transiently increase heart rate and blood pressure in humans. Moore MA, Weiskopf RB, Eger EI, Noorani M, McKay L, Damask M Rapid increase in desflurane concentration is associated with greater transient cardiovascular stimulation than with rapid increase in isoflurane concentration in humans. Weiskopf RB, Moore MA, Eger EI, Noorani M, McKay L, Chortkoff B, Hart PS, Damask M What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witnesses. Viele MK, Weiskopf RB The desflurane (Tec 6) vaporizer: design, design considerations and performance evaluation. Weiskopf RB, Sampson D, Moore MA Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine. Navarro R, Weiskopf RB, Moore MA, Lockhart S, Eger EI, Koblin D, Lu G, Wilson C Sympathetic hyperactivity during desflurane anesthesia. Eger EI, Weiskopf RB Comparing the costs of inhaled anesthetics. Weiskopf RB, Eger EI Arrhythmogenic doses of epinephrine are similar during desflurane or isoflurane anesthesia in humans. Moore MA, Weiskopf RB, Eger EI, Wilson C, Lu G Desflurane does not produce hepatic or renal injury in human volunteers. Weiskopf RB, Eger EI, Ionescu P, Yasuda N, Cahalan MK, Freire B, Peterson N, Lockhart SH, Rampil IJ, Laster M Cardiovascular actions of desflurane in normocarbic volunteers. Weiskopf RB, Cahalan MK, Eger EI, Yasuda N, Rampil IJ, Ionescu P, Lockhart SH, Johnson BH, Freire B, Kelley S Cardiovascular actions of desflurane with and without nitrous oxide during spontaneous ventilation in humans. Weiskopf RB, Cahalan MK, Ionescu P, Eger EI, Yasuda N, Lockhart SH, Rampil IJ, Laster M, Freire B, Peterson N Does desflurane modify circulatory responses to stimulation in humans? Yasuda N, Weiskopf RB, Cahalan MK, Ionescu P, Caldwell JE, Eger EI, Rampil IJ, Lockhart SH Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane. Sutton TS, Koblin DD, Gruenke LD, Weiskopf RB, Rampil IJ, Waskell L, Eger EI Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers. Cahalan MK, Weiskopf RB, Eger EI, Yasuda N, Ionescu P, Rampil IJ, Lockhart SH, Freire B, Peterson NA [Solubility of desflurane (I-653), sevoflurane, isoflurane, and halothane in human blood]. Yasuda N, Eger EI, Weiskopf RB, Tanifuji Y, Kobayashi K Clinical characteristics of desflurane in surgical patients: minimum alveolar concentration. Rampil IJ, Lockhart SH, Zwass MS, Peterson N, Yasuda N, Eger EI, Weiskopf RB, Damask MC Comparison of kinetics of sevoflurane and isoflurane in humans. Yasuda N, Lockhart SH, Eger EI, Weiskopf RB, Liu J, Laster M, Taheri S, Peterson NA Depression of ventilation by desflurane in humans. Lockhart SH, Rampil IJ, Yasuda N, Eger EI, Weiskopf RB Kinetics of desflurane, isoflurane, and halothane in humans. Yasuda N, Lockhart SH, Eger EI, Weiskopf RB, Johnson BH, Freire BA, Fassoulaki A Percutaneous loss of desflurane, isoflurane, and halothane in humans. Fassoulaki A, Lockhart SH, Freire BA, Yasuda N, Eger EI, Weiskopf RB, Johnson BH The electroencephalographic effects of desflurane in humans. Rampil IJ, Lockhart SH, Eger EI, Yasuda N, Weiskopf RB, Cahalan MK The neuromuscular effects of desflurane, alone and combined with pancuronium or succinylcholine in humans. Caldwell JE, Laster MJ, Magorian T, Heier T, Yasuda N, Lynam DP, Eger EI, Weiskopf RB Comparison of percutaneous losses of sevoflurane and isoflurane in humans. Lockhart SH, Yasuda N, Peterson N, Laster M, Taheri S, Weiskopf RB, Eger EI Pharmacokinetics of desflurane, sevoflurane, isoflurane, and halothane in pigs. Yasuda N, Targ AG, Eger EI, Johnson BH, Weiskopf RB Hepatocellular integrity in swine after prolonged desflurane (I-653) and isoflurane anesthesia: evaluation of plasma alanine aminotransferase activity. Holmes MA, Weiskopf RB, Eger EI, Johnson BH, Rampil IJ Cardiovascular actions of common anesthetic adjuvants during desflurane (I-653) and isoflurane anesthesia in swine. Weiskopf RB, Eger EI, Holmes MA, Yasuda N, Johnson BH, Targ AG, Rampil IJ Washin and washout of isoflurane administered via bubble oxygenators during hypothermic cardiopulmonary bypass. Nussmeier NA, Lambert ML, Moskowitz GJ, Cohen NH, Weiskopf RB, Fisher DM, Eger EI Cardiovascular safety and actions of high concentrations of I-653 and isoflurane in swine. Weiskopf RB, Holmes MA, Rampil IJ, Johnson BH, Yasuda N, Targ AG, Eger EI Epinephrine-induced premature ventricular contractions and changes in arterial blood pressure and heart rate during I-653, isoflurane, and halothane anesthesia in swine. Weiskopf RB, Eger EI, Holmes MA, Rampil IJ, Johnson B, Brown JG, Yasuda N, Targ AG Metabolism of I-653 and isoflurane in swine. Koblin DD, Weiskopf RB, Holmes MA, Konopka K, Rampil IJ, Eger EI, Waskell L Minimum alveolar concentration of I-653 and isoflurane in pigs: definition of a supramaximal stimulus. Eger EI, Johnson BH, Weiskopf RB, Holmes MA, Yasuda N, Targ A, Rampil IJ In vitro anesthetic washin and washout via bubble oxygenators: influence of anesthetic solubility and rates of carrier gas inflow and pump blood flow. Nussmeier NA, Moskowitz GJ, Weiskopf RB, Cohen NH, Fisher DM, Eger EI Cardiovascular effects of I653 in swine. Weiskopf RB, Holmes MA, Eger EI, Johnson BH, Rampil IJ, Brown JG I653 and isoflurane produce similar dose-related changes in the electroencephalogram of pigs. Rampil IJ, Weiskopf RB, Brown JG, Eger EI, Johnson BH, Holmes MA, Donegan JH Cardiovascular and metabolic sequelae of inducing anesthesia with ketamine or thiopental in hypovolemic swine. Weiskopf RB, Bogetz MS, Roizen MF, Reid IA The absence of an effect of halothane on blood hemoglobin O 2 equilibrium in vitro. Weiskopf RB, Nishimura M, Severinghaus JW
