Role Faculty Location UCSF at Mission Bay UCSF at Mount Zion UCSF at Parnassus Category Clinical Research Specialties Global Health Equity Neuroanesthesia Education 2019 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaResidency, - School of Medicine, University of California, San Francisco Publications Pulse oximeter performance and skin pigment: comparison of 34 oximeters using current and emerging regulatory frameworks. Hughes C, Chen D, Law T, Bickler P, Feiner J, Shmuylovich L, Behnke E, Ortiz L, Leeb G, Auchus I, Negussie F, Bisegerwa R, Zamora RV, Igaga E, Moore K, Okunlola O, Monk E, Fernandez JL, Ehie O, Wilks B, Oyefeso K, Schornack D, Sendagire C, Lipnick MS . medRxiv : the preprint server for health sciences . Aug 13, 2025 Differences in Arterial Oxygen Saturation Measurements Between Two Co-Oximeters From Different Manufacturers. Law TJ, Leeb G, van Wijk XMR, Kopotic RJ, Hendrickson C, Behnke E, Bickler PE, Feiner J, Vargas Zamora R, Lipnick MS . Respiratory care . Sep 16, 2025 Open Access Dataset and Common Data Model for Pulse Oximeter Performance Data. Fong N, Lipnick MS, Behnke E, Chou Y, Elmankabadi S, Ortiz L, Almond CS, Auchus I, Burnett GW, Bisegerwa R, Conrad DR, Hendrickson CM, Hooli S, Kopotic R, Leeb G, Martin D, McCollum ED, Monk EP, Moore KL, Shmuylovich L, Scott JB, Wong AI, Zhou T, Pirracchio R, Bickler PE, Feiner J, Law TJ . Scientific data . Apr 3, 2025 Comparison of methods for characterizing skin pigment diversity in research cohorts. Lipnick MS, Chen D, Law T, Moore K, Lester JC, Monk EP, Hendrickson CM, Chou Y, Hughes C, Behnke E, Elmankabadi S, Ortiz L, Negussie F, Leeb G, Ehie O, Auchus I, Igaga EN, Bisegerwa R, Okunlola O, Bickler P, Feiner J, Shmuylovich L . medRxiv : the preprint server for health sciences . Feb 25, 2025 Evaluation of Pulse Oximetry Accuracy in a Commercial Smartphone and Smartwatch Device During Human Hypoxia Laboratory Testing. Browne SH, Bernstein M, Bickler PE . Sensors (Basel, Switzerland) . Feb 20, 2025 In Response. Bickler PE, Feiner JR, Lipnick M . Anesthesia and analgesia . Oct 11, 2024 Open Access Data Repository and Common Data Model for Pulse Oximeter Performance Data. Fong N, Lipnick MS, Behnke E, Chou Y, Elmankabadi S, Ortiz L, Almond CS, Auchus I, Burnett GW, Bisegerwa R, Conrad DR, Hendrickson CM, Hooli S, Kopotic R, Leeb G, Martin D, McCollum ED, Monk EP, Moore KL, Shmuylovich L, Scott JB, Wong AI, Zhou T, Pirracchio R, Bickler PE, Feiner J, Law T . medRxiv : the preprint server for health sciences . Aug 31, 2024 Evidence Against Use of Nitrogen for the Death Penalty. Bickler PE, Lipnick MS . JAMA . May 29, 2024 The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment. Leeb G, Auchus I, Law T, Bickler P, Feiner J, Hashi S, Monk E, Igaga E, Bernstein M, Chou YC, Hughes C, Schornack D, Lester J, Moore K, Okunlola O, Fernandez J, Shmuylovich L, Lipnick M . EBioMedicine . Mar 7, 2024 Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin: A Prospective Study. Gudelunas MK, Lipnick M, Hendrickson C, Vanderburg S, Okunlola B, Auchus I, Feiner JR, Bickler PE . Anesthesia and analgesia . Dec 19, 2023 Searching for molecular hypoxia sensors among oxygen-dependent enzymes. Li L, Shen S, Bickler P, Jacobson MP, Wu LF, Altschuler SJ . eLife . Jul 26, 2023 Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study. Campbell LJ, Mummaneni PV, Letchuman V, Langnas E, Agarwal N, Guan LS, Croci R, Vargas E, Reisner L, Bickler P, Chou D, Chang E, Guan Z . Pain . Jun 15, 2023 Quantifying pulse oximeter accuracy during hypoxemia and severe anemia using an in vitro circulation system. Gylys R, Feiner J, Pologe J, Delianides T, Sutter S, Bickler P, Lipnick MS . Journal of clinical monitoring and computing . Jun 2, 2023 Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment. Bickler PE, Abouyannis M, Bhalla A, Lewin MR . Toxins . Jan 6, 2023 Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial. Srejic U, Litonius E, Gandhi S, Talke P, Maties O, Siegmueller C, Magsaysay A, Hasen D, Kunwar S, Seth R, Gibson L, Bickler P . Reviews on recent clinical trials . Jan 1, 2023 Pulse Oximeter Bias and Inequities in Retrospective Studies--Now What? Moore KL, Gudelunas K, Lipnick MS, Bickler PE, Hendrickson CM . Respiratory care . Dec 1, 2022 Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes. Lewin MR, Carter RW, Matteo IA, Samuel SP, Rao S, Fry BG, Bickler PE . Toxins . Nov 11, 2022 A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery. Barreto Chang OL, Whitlock EL, Arias AD, Tsoy E, Allen IE, Hellman J, Bickler PE, Miller B, Possin KL . Journal of the American Geriatrics Society . Sep 20, 2022 The Pulse Oximeter Is Amazing, but Not Perfect. Bickler P, Tremper KK . Anesthesiology . May 1, 2022 Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control. Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W . Frontiers in cellular neuroscience . Apr 26, 2022 Pulse Oximeter Performance, Racial Inequity, and the Work Ahead. Okunlola OE, Lipnick MS, Batchelder PB, Bernstein M, Feiner JR, Bickler PE . Respiratory care . Nov 12, 2021 John W. Severinghaus, M.D., 1922 to 2021. Bickler PE, Hornbein T, Saidman LJ . Anesthesiology . Oct 1, 2021 Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study. Bernholm KF, Meyhoff CS, Bickler P . BMJ open . Sep 17, 2021 Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease. Bickler SW, Cauvi DM, Fisch KM, Prieto JM, Sykes AG, Thangarajah H, Lazar DA, Ignacio RC, Gerstmann DR, Ryan AF, Bickler PE, De Maio A . BMC medical genomics . May 24, 2021 Accuracy of Samsung Smartphone Integrated Pulse Oximetry Meets Full FDA Clearance Standards for Clinical Use. Browne SH, Bernstein M, Bickler PE . medRxiv : the preprint server for health sciences . Feb 18, 2021 "Silent" Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19. Bickler PE, Feiner JR, Lipnick MS, McKleroy W . Anesthesiology . Feb 1, 2021 Amplification of Snake Venom Toxicity by Endogenous Signaling Pathways. Bickler PE . Toxins . Jan 22, 2020 Intraoperative physiological ranges associated with improved outcomes after major spine surgery: an observational study. Li G, Lin L, Xiao J, Rosenbaum S, Bickler P, Meng L . BMJ open . May 28, 2019 Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom. Lewin MR, Gilliam LL, Gilliam J, Samuel SP, Bulfone TC, Bickler PE, Gutiérrez JM . Toxins . Nov 17, 2018 Activation of orexin system facilitates anesthesia emergence and pain control. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY . Proceedings of the National Academy of Sciences of the United States of America . Oct 22, 2018 Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom. Lewin MR, Gutiérrez JM, Samuel SP, Herrera M, Bryan-Quirós W, Lomonte B, Bickler PE, Bulfone TC, Williams DJ . Toxins . Sep 20, 2018 Response to Burtscher re: "Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels". Bickler P, Feiner JR, Lundeberg J . High altitude medicine & biology . Sep 1, 2018 Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Bulfone TC, Samuel SP, Bickler PE, Lewin MR . Journal of tropical medicine . Jul 30, 2018 Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels. Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler PE . High altitude medicine & biology . Jun 20, 2018 Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion. Louie A, Feiner JR, Bickler PE, Rhodes L, Bernstein M, Lucero J . Anesthesiology . Mar 1, 2018 Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects. Lipnick MS, Cahill EA, Feiner JR, Bickler PE . Anesthesia and analgesia . Feb 1, 2018 Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance. Schober A, Feiner JR, Bickler PE, Rollins MD . Anesthesiology . Jan 1, 2018 Reduction in N-methyl-D-aspartate Receptor-mediated Cell Death in Hippocampal Neurons by Glucose Reduction Preconditioning. Yang N, Gabatto P, Bickler PE . Journal of neurosurgical anesthesiology . Oct 1, 2017 Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications. Srejic U, Larson P, Bickler PE . Anesthesia and analgesia . Jul 1, 2017 Interaction of Isoflurane, Tumor Necrosis Factor-α and β-Amyloid on Long-term Potentiation in Rat Hippocampal Slices. Zhou R, Bickler P . Anesthesia and analgesia . Feb 1, 2017 Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance. Bickler PE, Feiner JR, Lipnick MS, Batchelder P, MacLeod DB, Severinghaus JW . Anesthesia and analgesia . Jan 1, 2017 Tissue Oximetry and Clinical Outcomes. Bickler P, Feiner J, Rollins M, Meng L . Anesthesia and analgesia . Jan 1, 2017 Trends and Challenges in Clinical Monitoring: Papers From the 2015 IAMPOV Symposium. Bickler PE, Cannesson M, Shelley KH . Anesthesia and analgesia . Jan 1, 2017 Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Lewin M, Samuel S, Merkel J, Bickler P . Toxins . Aug 25, 2016 The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications. Lipnick MS, Feiner JR, Au P, Bernstein M, Bickler PE . Anesthesia and analgesia . Aug 1, 2016 Enough Information to Evaluate Clinical Monitors? Bickler PE . Anesthesia and analgesia . Jul 1, 2016 The Accuracy of Pulse Spectroscopy for Detecting Hypoxemia and Coexisting Methemoglobin or Carboxyhemoglobin. Kulcke A, Feiner J, Menn I, Holmer A, Hayoz J, Bickler P . Anesthesia and analgesia . Jun 1, 2016 Hypoxic preconditioning and cell death from oxygen/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons. Bickler PE, Clark JP, Gabatto P, Brosnan H . Neuroscience . Sep 25, 2015 Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of Naja naja (Indian Cobra) Envenomation. Lewin MR, Samuel SP, Wexler DS, Bickler P, Vaiyapuri S, Mensh BD . Journal of tropical medicine . May 14, 2014 Limitations of Mild, Moderate, and Profound Hypothermia in Protecting Developing Hippocampal Neurons After Simulated Ischemia. Gregersen M, Lee DH, Gabatto P, Bickler PE . Therapeutic hypothermia and temperature management . Dec 1, 2013 Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers. Bickler PE, Feiner JR, Rollins MD . Anesthesia and analgesia . Sep 10, 2013 Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers. Dubowitz G, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler PE . Anaesthesia . Aug 31, 2013 Xenon neurotoxicity in rat hippocampal slice cultures is similar to isoflurane and sevoflurane. Brosnan H, Bickler PE . Anesthesiology . Aug 1, 2013 Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation. Lewin MR, Bickler P, Heier T, Feiner J, Montauk L, Mensh B . Clinical case reports . Jul 24, 2013 Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia. Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler PE . Anesthesia and analgesia . Mar 11, 2013 Propofol at clinically relevant concentrations increases neuronal differentiation but is not toxic to hippocampal neural precursor cells in vitro. Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE . Anesthesiology . Nov 1, 2012 Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity. Bickler PE, Warren DE, Clark JP, Gabatto P, Gregersen M, Brosnan H . Anesthesiology . Aug 1, 2012 Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler PE, Lalchandani GR, Yusupova M, Woodward E, Kang H, Wilk AJ, Carlston CM, Mendoza MV, Guggenheim JN, Schaefer M, Rowe AM, Stratmann G . Anesthesiology . Mar 1, 2012 The emergence level of the musculocutaneous nerve from the brachial plexus: implications for infraclavicular nerve blocks. Pianezza A, Salces y Nedeo A, Chaynes P, Bickler PE, Minville V . Anesthesia and analgesia . Feb 6, 2012 Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity. Warren DE, Bickler PE, Clark JP, Gregersen M, Brosnan H, McKleroy W, Gabatto P . Neuroscience . Jan 12, 2012 Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation. Bickler PE, Fahlman CS, Gray JJ . Journal of neuroscience research . Oct 8, 2010 Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Feiner JR, Bickler PE . Anesthesia and analgesia . Sep 14, 2010 Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Bickler PE, Fahlman CS . Brain research . Apr 29, 2010 Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E, Bickler PE . Neuroscience research . Apr 14, 2010 Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Osredkar D, Sall JW, Bickler PE, Ferriero DM . Neurobiology of disease . Feb 1, 2010 Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Stratmann G, Sall JW, Bell JS, Alvi RS, May Ld, Ku B, Dowlatshahi M, Dai R, Bickler PE, Russell I, Lee MT, Hrubos MW, Chiu C . Anesthesiology . Feb 1, 2010 Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Feiner JR, Bickler PE, Mannheimer PD . Anesthesia and analgesia . Dec 10, 2009 Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures. Bickler PE, Fahlman CS . Anesthesiology . Aug 1, 2009 Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z, First International Workshop on Anesthetics and Alzheimer's Disease . Anesthesia and analgesia . May 1, 2009 Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons. Bickler PE, Fahlman CS, Gray J, McKleroy W . Neuroscience . Feb 13, 2009 Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK activation despite drastic ATP loss. Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler PE, Drew KL . Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . Apr 9, 2008 Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender. Feiner JR, Severinghaus JW, Bickler PE . Anesthesia and analgesia . Dec 1, 2007 Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability. Bickler PE, Buck LT . Annual review of physiology . Jan 1, 2007 Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin. Bickler P, Brandes J, Lee M, Bozic K, Chesbro B, Claassen J . Anesthesia and analgesia . Oct 1, 2006 The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia. Bickler PE, Fahlman CS . Anesthesia and analgesia . Aug 1, 2006 Isoflurane neuroprotection in rat hippocampal slices decreases with aging: changes in intracellular Ca2+ regulation and N-methyl-D-aspartate receptor-mediated Ca2+ influx. Zhan X, Fahlman CS, Bickler PE . Anesthesiology . May 1, 2006 Improvised cricothyrotomy provides reliable airway access in an unembalmed human cadaver model. Platts-Mills TF, Lewin MR, Wells J, Bickler P . Wilderness & environmental medicine . Jan 1, 2006 Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling. Bickler PE, Zhan X, Fahlman CS . Anesthesiology . Sep 1, 2005 Effects of skin pigmentation on pulse oximeter accuracy at low saturation. Bickler PE, Feiner JR, Severinghaus JW . Anesthesiology . Apr 1, 2005 Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2+ and mitogen-activated protein kinases. Gray JJ, Bickler PE, Fahlman CS, Zhan X, Schuyler JA . Anesthesiology . Mar 1, 2005 Intracellular calcium and survival of tadpole forebrain cells in anoxia. Hedrick MS, Fahlman CS, Bickler PE . The Journal of experimental biology . Feb 1, 2005 Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS . Brain research . Jan 21, 2005 Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Feiner JR, Bickler PE, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA . Anesthesia and analgesia . Jan 1, 2005 Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organisms. Bickler PE . The Journal of experimental biology . Aug 1, 2004 Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere). Paige M, Bickler PE . Anesthesia and analgesia . Aug 1, 2004 Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C. Bickler PE, Fahlman CS, Ferriero DM . Journal of neurochemistry . Feb 1, 2004 Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neurons. Bickler PE, Fahlman CS . Neuroscience . Jan 1, 2004 gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Bickler PE, Warner DS, Stratmann G, Schuyler JA . Anesthesia and analgesia . Aug 1, 2003 Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons. Bickler PE, Fahlman CS, Taylor DM . Neuroscience . Jan 1, 2003 Activation of the neuroprotective ERK signaling pathway by fructose-1,6-bisphosphate during hypoxia involves intracellular Ca2+ and phospholipase C. Fahlman CS, Bickler PE, Sullivan B, Gregory GA . Brain research . Dec 20, 2002 Adaptive responses of vertebrate neurons to hypoxia. Bickler PE, Donohoe PH . The Journal of experimental biology . Dec 1, 2002 Molecular adaptations for survival during anoxia: lessons from lower vertebrates. Bickler PE, Donohoe PH, Buck LT . The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry . Jun 1, 2002 Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U . Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . Mar 1, 2002 Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. Sullivan BL, Leu D, Taylor DM, Fahlman CS, Bickler PE . Anesthesiology . Jan 1, 2002 Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling. Donohoe PH, Fahlman CS, Bickler PE, Vexler ZS, Gregory GA . Brain research . Nov 2, 2001 The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA . Anesthesia and analgesia . Jul 1, 2001 Effects of neuroprotective cocktails on hippocampal neuron death in an in vitro model of cerebral ischemia. Liniger R, Popovic R, Sullivan B, Gregory G, Bickler PE . Journal of neurosurgical anesthesiology . Jan 1, 2001 Hypoxia-induced silencing of NMDA receptors in turtle neurons. Bickler PE, Donohoe PH, Buck LT . The Journal of neuroscience : the official journal of the Society for Neuroscience . May 15, 2000 Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. Popovic R, Liniger R, Bickler PE . Anesthesiology . May 1, 2000 Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats. Taylor DM, Eger EI, Bickler PE . Anesthesia and analgesia . Oct 1, 1999 Different effects of volatile anesthetics and polyhalogenated alkanes on depolarization-evoked glutamate release in rat cortical brain slices. Eilers H, Kindler CH, Bickler PE . Anesthesia and analgesia . May 1, 1999 Volatile anesthetics increase intracellular calcium in cerebrocortical and hippocampal neurons. Kindler CH, Eilers H, Donohoe P, Ozer S, Bickler PE . Anesthesiology . Apr 1, 1999 Reversible decreases in ATP and PCr concentrations in anoxic turtle brain. Buck L, Espanol M, Litt L, Bickler P . Comparative biochemistry and physiology. Part A, Molecular & integrative physiology . Aug 1, 1998 Reduction of NMDA receptor activity in cerebrocortex of turtles (Chrysemys picta) during 6 wk of anoxia. Bickler PE . The American journal of physiology . Jul 1, 1998 Adaptations of vertebrate neurons to hypoxia and anoxia: maintaining critical Ca2+ concentrations. Bickler PE, Buck LT . The Journal of experimental biology . Apr 1, 1998 Hypoxia-tolerant neonatal CA1 neurons: relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices. Bickler PE, Hansen BM . Brain research. Developmental brain research . Mar 12, 1998 Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE . Journal of neurochemistry . Feb 1, 1998 Adenosine and anoxia reduce N-methyl-D-aspartate receptor open probability in turtle cerebrocortex. Buck LT, Bickler PE . The Journal of experimental biology . Jan 1, 1998 Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism. Eilers H, Schaeffer E, Bickler PE, Forsayeth JR . Molecular pharmacology . Dec 1, 1997 Interactive effects of pH and temperature on N-methyl-D-aspartate receptor activity in rat cortical brain slices. Gray AT, Buck LT, Feiner JR, Bickler PE . Journal of neurosurgical anesthesiology . Apr 1, 1997 Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia. Bickler PE, Buck LT . Journal of neurochemistry . Oct 1, 1996 Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Talke P, Bickler PE . Anesthesiology . Sep 1, 1996 Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. Eilers H, Bickler PE . Anesthesiology . Sep 1, 1996 Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Severinghaus JW, Wagner PD . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 1996 Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 1996 Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Bickler PE, Hansen BM . Neuropharmacology . Jun 1, 1996 Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia. Bickler PE, Buck LT, Feiner JR . Anesthesiology . Dec 1, 1995 Role of adenosine in NMDA receptor modulation in the cerebral cortex of an anoxia-tolerant turtle (Chrysemys picta belli). Buck LT, Bickler PE . The Journal of experimental biology . Jul 1, 1995 Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Feiner JR, Bickler PE, Severinghaus JW . Respiration physiology . Jun 1, 1995 Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage. Bickler PE, Hansen BM . Brain research . Dec 5, 1994 Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Bickler PE, Buck LT, Hansen BM . Anesthesiology . Dec 1, 1994 Time course of augmentation and depression of hypoxic ventilatory responses at altitude. Sato M, Severinghaus JW, Bickler P . Journal of applied physiology (Bethesda, Md. : 1985) . Jul 1, 1994 Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity. Cardone C, Szenohradszky J, Yost S, Bickler PE . Anesthesiology . May 1, 1994 Influence of pH on calcium influx during hypoxia in rat cortical brain slices. O'Donnell BR, Bickler PE . Stroke . Jan 1, 1994 Developmental changes in intracellular calcium regulation in rat cerebral cortex during hypoxia. Bickler PE, Gallego SM, Hansen BM . Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . Sep 1, 1993 Inhibition of brain calcium channels by plasma proteins from anoxic turtles. Bickler PE, Gallego SM . The American journal of physiology . Aug 1, 1993 Central nervous system effects of intrathecal muscle relaxants in rats. Szenohradszky J, Trevor AJ, Bickler P, Caldwell JE, Sharma ML, Rampil IJ, Miller RD . Anesthesia and analgesia . Jun 1, 1993 Cerebral anoxia tolerance in turtles: regulation of intracellular calcium and pH. Bickler PE . The American journal of physiology . Dec 1, 1992 Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats. Bickler PE, Kelleher JA . Stroke . Nov 1, 1992 Regional cerebral blood flow and tissue oxygenation during hypocarbia in geese. Bickler PE, Julian D . The American journal of physiology . Aug 1, 1992 Mass spectrometers and infrared gas analyzers interpret bronchodilator propellants as anesthetic gases. Bickler PE, Sohn YJ . Anesthesia and analgesia . Jul 1, 1992 Effects of temperature and anoxia on regional cerebral blood flow in turtles. Bickler PE . The American journal of physiology . Mar 1, 1992 The laryngeal mask airway. An unusual complication. Miller AC, Bickler P . Anaesthesia . Aug 1, 1991 Intracranial pressure and brain redox balance in rabbits. Bissonnette B, Bickler PE, Gregory GA, Severinghaus JW . Canadian journal of anaesthesia = Journal canadien d'anesthesie . Jul 1, 1991 Intralipid solution mistakenly infused into epidural space. Bickler P, Spears R, McKay W . Anesthesia and analgesia . Dec 1, 1990 Efficiency of airway heat and moisture exchangers in anesthetized humans. Bickler PE, Sessler DI . Anesthesia and analgesia . Oct 1, 1990 Acute radial nerve injury from use of an automatic blood pressure monitor. Bickler PE, Schapera A, Bainton CR . Anesthesiology . Jul 1, 1990 Diffusion of felt-tip marker pen ink into intravenous bags. Bickler PE, Gold B, Johnson BH . Anesthesia and analgesia . Sep 1, 1989 Effects of hypoxia and hypocapnia on brain redox balance in ducks. Bickler PE, Koh SO, Severinghaus JW . The American journal of physiology . Jul 1, 1989 Effects of acetazolamide on cerebral acid-base balance. Bickler PE, Litt L, Banville DL, Severinghaus JW . Journal of applied physiology (Bethesda, Md. : 1985) . Jul 1, 1988 Effects of acetazolamide on cerebrocortical NADH and blood volume. Bickler PE, Litt L, Severinghaus JW . Journal of applied physiology (Bethesda, Md. : 1985) . Jul 1, 1988 Effects of barbiturate anesthesia on functional residual capacity and ribcage/diaphragm contributions to ventilation. Bickler PE, Dueck R, Prutow RJ . Anesthesiology . Feb 1, 1987 Blood respiratory properties in pigeons at high altitudes: effects of acclimation. Weinstein Y, Bernstein MH, Bickler PE, Gonzales DV, Samaniego FC, Escobedo MA . The American journal of physiology . Dec 1, 1985 Blood acid-base status of an awake heterothermic rodent, Spermophilus tereticaudus. Bickler PE . Respiration physiology . Sep 1, 1984 CO2 balance of a heterothermic rodent: comparison of sleep, torpor, and awake states. Bickler PE . The American journal of physiology . Jan 1, 1984
