Biography Dr. Pekka Talke is an anesthesiologist with more than 30 years of experience. He cared for patients in the operating rooms with a particular focus on neuroanesthesia (optimizing anesthesia during neurological surgeries). He served as chief of neuroanesthesia for 15 years. For more than three decades, Talke has conducted research that focuses on noninvasive physiological monitoring (using devices outside the body to continuously assess a patient's status) and blood vessel function. Talke earned his medical degree at the University of Texas Medical Branch at Galveston, where he also completed a residency in anesthesiology. He is a member of the Society for Neuroscience in Anesthesiology and Critical Care, and has served on its board of directors. Talke is a native of Finland. Role Faculty Category Clinical Education Residency, 1989 - Anesthesiology, UT Medical Branch at GalvestonMD, 1985 - Medicine, UT Medical Branch at Galveston Publications Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. Talke P, Talke I Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial. Srejic U, Litonius E, Gandhi S, Talke P, Maties O, Siegmueller C, Magsaysay A, Hasen D, Kunwar S, Seth R, Gibson L, Bickler P Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Sleigh JW, Vacas S, Flexman AM, Talke PO Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. Talke P, Anderson BJ The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Talke P Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study. Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke. Gelb AW, Talke PO Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm. Flexman AM, Ryerson CJ, Talke PO Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects. Talke P, Snapir A, Huiku M Photoplethysmographic waveform: what do the numbers mean? Talke P Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS Recent advances in pulse oximetry. Cannesson M, Talke P It's hot to be cool. Talke PO Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M Expecting the unexpected. Talke PO, Maze M Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. Talke P, Stapelfeldt C, Garcia P Effect of peripheral vasoconstriction on pulse oximetry. Talke P, Stapelfeldt C Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow. Maybauer DM, Talke PO, Westphal M, Maybauer MO, Traber LD, Enkhbaatar P, Morita N, Traber DL Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging. Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA Intraoperative clonidine administration to neurosurgical patients. Talke PO, Lobo EP, Stapelfeldt C, Brown R Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A Postcraniotomy pain remains a real headache! Talke PO, Gelb AW Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A Intraoperative clonidine administration to neurosurgical patients. Stapelfeldt C, Lobo EP, Brown R, Talke PO Intracranial vascular surgery. Talke P Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Talke P, Lobo E, Brown R Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Talke P, Xu M, Paloheimo M, Kalso E Autonomic nervous system responses during sedative infusions of dexmedetomidine. Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery. Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA Clonidine-induced vasoconstriction in awake volunteers. Talke PO, Lobo EP, Brown R, Richardson CA Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. Gao DW, Talke PO, Dae MW Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Larson MD, Talke PO The effects of clonidine on human digital vasculature. Talke PO, Caldwell JE, Richardson CA, Heier T The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep. Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Talke P, Caldwell JE, Richardson CA Amount of air infused to patient increases as fluid flow rates decrease when using the Hotline HL-90 fluid warmer. Woon S, Talke P The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M Concept for easy fiberoptic intubation via a laryngeal airway mask. Talke PO, Nguyen H Receptor-specific reversible sedation: beginning of new era of anesthesia? Talke P Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Talke P, Richardson CA, Scheinin M, Fisher DM Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers. Lee HW, Caldwell JE, Dodson B, Talke P, Howley J Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Talke P, Caldwell J, Dodsont B, Richardson CA Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Talke P, Bickler PE Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients. Talke PO, Solanki DR Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S Measurement of systolic blood pressure using pulse oximetry during helicopter flight. Talke PO Monitoring patients during helicopter flight. Talke P, Nichols RJ, Traber DL Does measurement of systolic blood pressure with a pulse oximeter correlate with conventional methods? Talke P, Nichols RJ, Traber DL Effects of allopurinol on smoke inhalation in the ovine model. Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD, Herndon DN, Traber DL A model of ovine endotoxemia characterized by an increased cardiac output. Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D Transcutaneous PO2 measurements in health and peripheral arterial occlusive disease. Franzeck UK, Talke P, Bernstein EF, Golbranson FL, Fronek A
