Biography Dr. Pekka Talke is an anesthesiologist with more than 30 years of experience. He cared for patients in the operating rooms with a particular focus on neuroanesthesia (optimizing anesthesia during neurological surgeries). He served as chief of neuroanesthesia for 15 years. For more than three decades, Talke has conducted research that focuses on noninvasive physiological monitoring (using devices outside the body to continuously assess a patient's status) and blood vessel function. Talke earned his medical degree at the University of Texas Medical Branch at Galveston, where he also completed a residency in anesthesiology. He is a member of the Society for Neuroscience in Anesthesiology and Critical Care, and has served on its board of directors. Talke is a native of Finland. Role Faculty Category Clinical Education Residency, 1989 - Anesthesiology, UT Medical Branch at GalvestonMD, 1985 - Medicine, UT Medical Branch at Galveston Publications Vasomotion in Human Fingers. Talke P, Maltz JS, Talke M, Scheinin M, Diab MK Journal of vascular research . Aug 26, 2025 Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. Talke P, Talke I Journal of pain research . Jan 9, 2024 Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial. Srejic U, Litonius E, Gandhi S, Talke P, Maties O, Siegmueller C, Magsaysay A, Hasen D, Kunwar S, Seth R, Gibson L, Bickler P Reviews on recent clinical trials . Jan 1, 2023 Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Sleigh JW, Vacas S, Flexman AM, Talke PO Anesthesia and analgesia . Oct 1, 2018 Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. Talke P, Anderson BJ British journal of clinical pharmacology . Apr 2, 2018 The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Talke P Anesthesiology research and practice . Apr 2, 2017 Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD Stroke . Aug 1, 2014 Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study. Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO Anesthesiology . May 1, 2014 Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD Journal of neurosurgical anesthesiology . Apr 1, 2014 The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke. Gelb AW, Talke PO Anesthesiology . Sep 1, 2012 Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm. Flexman AM, Ryerson CJ, Talke PO Anesthesia and analgesia . Mar 26, 2012 Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E British journal of anaesthesia . Feb 26, 2012 The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects. Talke P, Snapir A, Huiku M Anesthesia and analgesia . Apr 25, 2011 Photoplethysmographic waveform: what do the numbers mean? Talke P Acta anaesthesiologica Scandinavica . Aug 1, 2010 Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS Journal of neurosurgery . Mar 1, 2010 Recent advances in pulse oximetry. Cannesson M, Talke P F1000 medicine reports . Aug 26, 2009 It's hot to be cool. Talke PO Anesthesiology . Jul 1, 2009 Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M British journal of anaesthesia . Nov 5, 2008 Expecting the unexpected. Talke PO, Maze M Anesthesia and analgesia . Jun 1, 2008 Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. Talke P, Stapelfeldt C, Garcia P Journal of neurosurgical anesthesiology . Jul 1, 2007 Effect of peripheral vasoconstriction on pulse oximetry. Talke P, Stapelfeldt C Journal of clinical monitoring and computing . Jul 14, 2006 Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow. Maybauer DM, Talke PO, Westphal M, Maybauer MO, Traber LD, Enkhbaatar P, Morita N, Traber DL Anaesthesia and intensive care . Jun 1, 2006 Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging. Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA Magnetic resonance in medicine . Nov 1, 2005 Intraoperative clonidine administration to neurosurgical patients. Talke PO, Lobo EP, Stapelfeldt C, Brown R Anesthesia and analgesia . Sep 1, 2005 Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A Pharmacogenetics and genomics . May 1, 2005 Postcraniotomy pain remains a real headache! Talke PO, Gelb AW European journal of anaesthesiology . May 1, 2005 Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A Anesthesiology . Mar 1, 2005 Intraoperative clonidine administration to neurosurgical patients. Stapelfeldt C, Lobo EP, Brown R, Talke PO Anesthesia and analgesia . Jan 1, 2005 Intracranial vascular surgery. Talke P Current opinion in anaesthesiology . Oct 1, 2004 Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Talke P, Lobo E, Brown R Anesthesiology . Jul 1, 2003 Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Talke P, Xu M, Paloheimo M, Kalso E Acta anaesthesiologica Scandinavica . Mar 1, 2003 Autonomic nervous system responses during sedative infusions of dexmedetomidine. Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI Anesthesiology . Sep 1, 2002 A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery. Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA Anesthesia and analgesia . Aug 1, 2002 Clonidine-induced vasoconstriction in awake volunteers. Talke PO, Lobo EP, Brown R, Richardson CA Anesthesia and analgesia . Aug 1, 2001 Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. Gao DW, Talke PO, Dae MW Journal of autonomic pharmacology . Jun 1, 2001 Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Larson MD, Talke PO British journal of clinical pharmacology . Jan 1, 2001 The effects of clonidine on human digital vasculature. Talke PO, Caldwell JE, Richardson CA, Heier T Anesthesia and analgesia . Oct 1, 2000 The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep. Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD Anesthesia and analgesia . May 1, 2000 The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A Anesthesia and analgesia . Apr 1, 2000 Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Talke P, Caldwell JE, Richardson CA Anesthesiology . Jul 1, 1999 Amount of air infused to patient increases as fluid flow rates decrease when using the Hotline HL-90 fluid warmer. Woon S, Talke P Journal of clinical monitoring and computing . May 1, 1999 The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M Anesthesia and analgesia . Mar 1, 1999 Concept for easy fiberoptic intubation via a laryngeal airway mask. Talke PO, Nguyen H Anesthesia and analgesia . Jan 1, 1999 Receptor-specific reversible sedation: beginning of new era of anesthesia? Talke P Anesthesiology . Sep 1, 1998 Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Talke P, Richardson CA, Scheinin M, Fisher DM Anesthesia and analgesia . Nov 1, 1997 Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C Anesthesiology . Oct 1, 1997 The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers. Lee HW, Caldwell JE, Dodson B, Talke P, Howley J Anesthesiology . Sep 1, 1997 Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA Anesthesia and analgesia . Aug 1, 1997 Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Talke P, Caldwell J, Dodsont B, Richardson CA Anesthesiology . Nov 1, 1996 Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Talke P, Bickler PE Anesthesiology . Sep 1, 1996 Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT Anesthesiology . Mar 1, 1995 Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients. Talke PO, Solanki DR Anesthesia and analgesia . Dec 1, 1993 Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S Anesthesiology . Jan 1, 1993 Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S European journal of anaesthesiology. Supplement . Nov 1, 1992 Measurement of systolic blood pressure using pulse oximetry during helicopter flight. Talke PO Critical Care Medicine . Jul 1, 1991 Monitoring patients during helicopter flight. Talke P, Nichols RJ, Traber DL Journal of clinical monitoring . Apr 1, 1990 Does measurement of systolic blood pressure with a pulse oximeter correlate with conventional methods? Talke P, Nichols RJ, Traber DL Journal of clinical monitoring . Jan 1, 1990 Effects of allopurinol on smoke inhalation in the ovine model. Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD, Herndon DN, Traber DL Journal of applied physiology (Bethesda, Md. : 1985) . Jan 1, 1990 A model of ovine endotoxemia characterized by an increased cardiac output. Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D Circulatory shock . Jan 1, 1985 Transcutaneous PO2 measurements in health and peripheral arterial occlusive disease. Franzeck UK, Talke P, Bernstein EF, Golbranson FL, Fronek A Surgery . Feb 1, 1982
