Role
Pekka Talke, MD
Professor of Clinical Anesthesia
Biography:
Dr. Pekka Talke is an anesthesiologist with more than 30 years of experience. He cares for patients in the operating rooms with a particular focus on neuroanesthesia (optimizing anesthesia during neurological surgeries). He served as chief of neuroanesthesia for 15 years.
For more than three decades, Talke has conducted research that focuses on noninvasive physiological monitoring (using devices outside the body to continuously assess a patient's status) and blood vessel function.
Talke earned his medical degree at the University of Texas Medical Branch at Galveston, where he also completed a residency in anesthesiology. He is a member of the Society for Neuroscience in Anesthesiology and Critical Care, and has served on its board of directors.
Talke is a native of Finland.
Publications:
Talke P, Talke I. Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. J Pain Res. 2024; 17:209-217.
Srejic U, Litonius E, Gandhi S, Talke P, Maties O, Siegmueller C, Magsaysay A, Hasen D, Kunwar S, Seth R, Gibson L, Bickler P. Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial. Rev Recent Clin Trials. 2023; 18(3):228-237.
Sleigh JW, Vacas S, Flexman AM, Talke PO. Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Anesth Analg. 2018 10; 127(4):951-959.
Talke P, Anderson BJ. Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. Br J Clin Pharmacol. 2018 06; 84(6):1364-1372.
Talke P. The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Anesthesiol Res Pract. 2017; 2017:7646541.
Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke. Stroke. 2014 Aug; 45(8):e138-50.
Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO. Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study. Anesthesiology. 2014 May; 120(5):1118-25.
Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society. J Neurosurg Anesthesiol. 2014 Apr; 26(2):95-108.
Gelb AW, Talke PO. The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke. Anesthesiology. 2012 Sep; 117(3):683-4; author reply 684.
Flexman AM, Ryerson CJ, Talke PO. Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm. Anesth Analg. 2012 Jun; 114(6):1292-6.
Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E. Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Br J Anaesth. 2012 May; 108(5):838-44.
Talke P, Snapir A, Huiku M. The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects. Anesth Analg. 2011 Jul; 113(1):78-83.
Talke P. Photoplethysmographic waveform: what do the numbers mean? Acta Anaesthesiol Scand. 2010 Aug; 54(7):900; author reply 900.
Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS. Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. J Neurosurg. 2010 Mar; 112(3):479-90.
Cannesson M, Talke P. Recent advances in pulse oximetry. F1000 Med Rep. 2009 Aug 26; 1.
Talke PO. It's hot to be cool. Anesthesiology. 2009 Jul; 111(1):10-1.
Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M. Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Br J Anaesth. 2009 Jan; 102(1):38-46.
Talke PO, Maze M. Expecting the unexpected. Anesth Analg. 2008 Jun; 106(6):1605-6.
Talke P, Stapelfeldt C, Garcia P. Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. J Neurosurg Anesthesiol. 2007 Jul; 19(3):195-9.
Talke P, Stapelfeldt C. Effect of peripheral vasoconstriction on pulse oximetry. J Clin Monit Comput. 2006 Oct; 20(5):305-9.
Maybauer DM, Talke PO, Westphal M, Maybauer MO, Traber LD, Enkhbaatar P, Morita N, Traber DL. Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow. Anaesth Intensive Care. 2006 Jun; 34(3):329-33.
Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA. Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging. Magn Reson Med. 2005 Nov; 54(5):1107-14.
Talke PO, Lobo EP, Stapelfeldt C, Brown R. Intraoperative clonidine administration to neurosurgical patients. Anesth Analg. 2005 Sep; 101(3):923.
Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Pharmacogenet Genomics. 2005 May; 15(5):357-63.
Talke PO, Gelb AW. Postcraniotomy pain remains a real headache! Eur J Anaesthesiol. 2005 May; 22(5):325-7.
Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Anesthesiology. 2005 Mar; 102(3):536-42.
Stapelfeldt C, Lobo EP, Brown R, Talke PO. Intraoperative clonidine administration to neurosurgical patients. Anesth Analg. 2005 Jan; 100(1):226-232.
Talke P. Intracranial vascular surgery. Curr Opin Anaesthesiol. 2004 Oct; 17(5):357-61.
Talke P, Lobo E, Brown R. Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Anesthesiology. 2003 Jul; 99(1):65-70.
Talke P, Xu M, Paloheimo M, Kalso E. Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Acta Anaesthesiol Scand. 2003 Mar; 47(3):347-54.
Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI. Autonomic nervous system responses during sedative infusions of dexmedetomidine. Anesthesiology. 2002 Sep; 97(3):592-8.
Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA. A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery. Anesth Analg. 2002 Aug; 95(2):430-5, table of contents.
Larson MD, Talke PO. Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Br J Clin Pharmacol. 2001 Jan; 51(1):27-33.
Talke PO, Caldwell JE, Richardson CA, Heier T. The effects of clonidine on human digital vasculature. Anesth Analg. 2000 Oct; 91(4):793-7.
Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD. The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep. Anesth Analg. 2000 May; 90(5):1060-6.
Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg. 2000 Apr; 90(4):834-9.
Talke P, Caldwell JE, Richardson CA. Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1999 Jul; 91(1):127-30.
Woon S, Talke P. Amount of air infused to patient increases as fluid flow rates decrease when using the Hotline HL-90 fluid warmer. J Clin Monit Comput. 1999 May; 15(3-4):149-52.
Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M. The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Anesth Analg. 1999 Mar; 88(3):633-9.
Talke PO, Nguyen H. Concept for easy fiberoptic intubation via a laryngeal airway mask. Anesth Analg. 1999 Jan; 88(1):228-9.
Talke P. Receptor-specific reversible sedation: beginning of new era of anesthesia? Anesthesiology. 1998 Sep; 89(3):560-1.
Talke P, Richardson CA, Scheinin M, Fisher DM. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg. 1997 Nov; 85(5):1136-42.
Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology. 1997 Oct; 87(4):835-41.
Lee HW, Caldwell JE, Dodson B, Talke P, Howley J. The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers. Anesthesiology. 1997 Sep; 87(3):553-8.
Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth Analg. 1997 Aug; 85(2):358-64.
Talke P, Caldwell J, Dodsont B, Richardson CA. Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1996 Nov; 85(5):999-1004.
Talke P, Bickler PE. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. 1996 Sep; 85(3):551-7.
Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33.
Talke PO, Solanki DR. Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients. Anesth Analg. 1993 Dec; 77(6):1143-8.
Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology. 1993 Jan; 78(1):15-20.
Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl. 1992 Nov; 6:55-62.
Talke PO. Measurement of systolic blood pressure using pulse oximetry during helicopter flight. Crit Care Med. 1991 Jul; 19(7):934-7.
Talke P, Nichols RJ, Traber DL. Monitoring patients during helicopter flight. J Clin Monit. 1990 Apr; 6(2):139-40.
Talke P, Nichols RJ, Traber DL. Does measurement of systolic blood pressure with a pulse oximeter correlate with conventional methods? J Clin Monit. 1990 Jan; 6(1):5-9.
Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD, Herndon DN, Traber DL. Effects of allopurinol on smoke inhalation in the ovine model. J Appl Physiol (1985). 1990 Jan; 68(1):228-34.
Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D. A model of ovine endotoxemia characterized by an increased cardiac output. Circ Shock. 1985; 17(2):103-8.
Franzeck UK, Talke P, Bernstein EF, Golbranson FL, Fronek A. Transcutaneous PO2 measurements in health and peripheral arterial occlusive disease. Surgery. 1982 Feb; 91(2):156-63.