Biography Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine. Role Faculty Category Clinical Specialties Critical Care Medicine Education Fellowship, 1979 - Cardiovascular Research Institute, University of California, San FranciscoFellowship, 1978 - Pulmonary DIvision, University of California, San FranciscoInternship and Residency, 1976 - Internal Medicine, University of Colorado Medical CenterM.D., 1973 - School of Medicine, University of PennsylvaniaA.B., 1969 - English, Harvard University Publications A fibroblast-dependent TGFß1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis. Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Jourdan Le Saux C NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection. Zhao C, Pan M, Chen J, Li L, Zhang Y, Liu W, Matthay MA, Wang H, Jin X, Xu JF, Su X Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials. Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study. Jensen TO, Murray TA, Grandits GA, Jain MK, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure S, Leshnower BG, Looney D, Moschopoulos CD, Mugerwa H, Murray DD, Mylonakis E, Nagy-Agren S, Rehman MT, Rupert A, Stevens R, Turville S, Weintrob A, Wick K, Lundgren J, Ko ER, ACTIV-3/TICO Study Group Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice. Taenaka H, Fang X, Maishan M, Trivedi A, Wick KD, Gotts JE, Martin TR, Calfee CS, Matthay MA Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial. Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinic Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS Life-saving effect of pulmonary surfactant in premature babies. Raj JU, Bland RD, Bhattacharya J, Rabinovitch M, Matthay MA Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome. Baedorf-Kassis E, Murn M, Dzierba AL, Serra AL, Garcia I, Minus E, Padilla C, Sarge T, Goodspeed VM, Matthay MA, Gong MN, Cook D, Loring SH, Talmor D, Beitler JR, EPVent-2 Study Group Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia. Chouchane O, Schuurman AR, Reijnders TDY, Peters-Sengers H, Butler JM, Uhel F, Schultz MJ, Bonten MJ, Cremer OL, Calfee CS, Matthay MA, Langley RJ, Alipanah-Lechner N, Kingsmore SF, Rogers A, Weeghel MV, Vaz FM, van der Poll T Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock. Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN Cell-based Therapies for ARDS - Where Are We Now? Curley GF, O'Kane CM, McAuley DF, Matthay MA, Laffey JG Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time. Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS, NHLBI PETAL Network Inter- and Intra-donor variability in bone marrow-derived mesenchymal stromal cells: implications for clinical applications. Trivedi A, Lin M, Miyazawa B, Nair A, Vivona L, Fang X, Bieback K, Schäfer R, Spohn G, McKenna D, Zhuo H, Matthay MA, Pati S Reply to Du, et al. and Palanidurai, et al. Matthay MA, Ware LB, Riviello ED, Wick KD, Thompson T, Martin TR Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19. Jensen TO, Grandits GA, Jain MK, Murray TA, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure S, Leshnower BG, Looney D, Moschopoulos CD, Mugerwa H, Murray DD, Mylonakis E, Nagy-Agren S, Rehman MT, Rupert A, Stevens RA, Turville S, Weintrob A, Wick K, Lundgren J, Ko ER, ACTIV-3/TICO Study Group The Translational Value of Rodent Models of Sepsis. Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial. Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS). Mehta P, Samanta RJ, Wick K, Coll RC, Mawhinney T, McAleavey PG, Boyle AJ, Conlon J, Shankar-Hari M, Rogers A, Calfee CS, Matthay MA, Summers C, Chambers RC, McAuley DF, O'Kane CM The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients. Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR A New Global Definition of Acute Respiratory Distress Syndrome. Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri VM, Riviello ED, Rubin E, Slutsky AS, Thompson BT, Twagirumugabe T, Ware LB, Wick KD Unraveling the enigma of genetics and phenotypes in ARDS. Artigas A, Barbas CSV, Matthay MA In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia. Jayasimhan D, Matthay MA Evidence for lung barrier regeneration by differentiation prior to binucleated and stem cell division. Guild J, Juul NH, Andalon A, Taenaka H, Coffey RJ, Matthay MA, Desai TJ MicroRNA-1 protects the endothelium in acute lung injury. Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay MA, Pober JS, Pierce RW, Takyar SS The antibiotic resistance reservoir of the lung microbiome expands with age. Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials. Moore AR, Pienkos SM, Sinha P, Guan J, O'Kane CM, Levitt JE, Wilson JG, Shankar-Hari M, Matthay MA, Calfee CS, Baron RM, McAuley DF, Rogers AJ Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series. Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. Brown SM, Barkauskas CE, Grund B, Sharma S, Phillips AN, Leither L, Peltan ID, Lanspa M, Gilstrap DL, Mourad A, Lane K, Beitler JR, Serra AL, Garcia I, Almasri E, Fayed M, Hubel K, Harris ES, Middleton EA, Barrios MAG, Mathews KS, Goel NN, Acquah S, Mosier J, Hypes C, Salvagio Campbell E, Khan A, Hough CL, Wilson JG, Levitt JE, Duggal A, Dugar S, Goodwin AJ, Terry C, Chen P, Torbati S, Iyer N, Sandkovsky US, Johnson NJ, Robinson BRH, Matthay MA, Aggarwal NR, Douglas IS, Casey JD, Hache-Marliere M, Georges Youssef J, Nkemdirim W, Leshnower B, Awan O, Pannu S, O'Mahony DS, Manian P, Awori Hayanga JW, Wortmann GW, Tomazini BM, Miller RF, Jensen JU, Murray DD, Bickell NA, Zatakia J, Burris S, Higgs ES, Natarajan V, Dewar RL, Schechner A, Kang N, Arenas-Pinto A, Hudson F, Ginde AA, Self WH, Rogers AJ, Oldmixon CF, Morin H, Sanchez A, Weintrob AC, Cavalcanti AB, Davis-Karim A, Engen N, Denning E, Taylor Thompson B, Gelijns AC, Kan V, Davey VJ, Lundgren JD, Babiker AG, Neaton JD, Lane HC, ACTIV-3b/Therapeutics for Severely Ill Inpatients with COVID-19 (TESICO) Study Group ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'Arrigo S, De Backer D, Demoule A, Einav S, Fan E, Ferguson ND, Frat JP, Gattinoni L, Guérin C, Herridge MS, Hodgson C, Hough CL, Jaber S, Juffermans NP, Karagiannidis C, Kesecioglu J, Kwizera A, Laffey JG, Mancebo J, Matthay MA, McAuley DF, Mercat A, Meyer NJ, Moss M, Munshi L, Myatra SN, Ng Gong M, Papazian L, Patel BK, Pellegrini M, Perner A, Pesenti A, Piquilloud L, Qiu H, Ranieri MV, Riviello E, Slutsky AS, Stapleton RD, Summers C, Thompson TB, Valente Barbas CS, Villar J, Ware LB, Weiss B, Zampieri FG, Azoulay E, Cecconi M, European Society of Intensive Care Medicine Taskforce on ARDS Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM Should We Add Fludrocortisone to Hydrocortisone for Treatment of Septic Shock? Matthay MA, Dahabreh IJ, Thompson BT Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS. Mahida RY, Lax S, Bassford CR, Scott A, Parekh D, Hardy RS, Naidu B, Matthay MA, Stewart PM, Cooper MC, Perkins GD, Thickett DR Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. Zinter MS, Markovic D, Asaro LA, Nadkarni VM, McQuillen PS, Sinha P, Matthay MA, Jeschke MG, Agus MSD, Sapru A, CAF-PINT Investigators of the PALISI Network Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials. Pienkos SM, Moore AR, Guan J, Levitt JE, Matthay MA, Baron RM, Conlon J, McAuley DF, O'Kane CM, Rogers AJ Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19. Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nuñez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior. Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith LZ Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T Are circulating endothelial cells the next target for transcriptome-level pathway analysis in ARDS? Costa Monteiro AC, Matthay MA Myeloid Extracellular Vesicles: New Players in Indirect Lung Injury. Mahida RY, Matthay MA Understanding the Role of Mesenchymal Stromal Cells in Treating COVID-19 Acute Respiratory Distress Syndrome. O'Kane CM, Matthay MA Mechanisms of impaired alveolar fluid clearance. Taenaka H, Matthay MA Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS. Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS Lessons From a Negative Clinical Trial: Novel Immunological Targets for COVID-19 and Beyond. Sullivan KM, Matthay MA Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score. Jensen CM, Costa JC, Nørgaard JC, Zucco AG, Neesgaard B, Niemann CU, Ostrowski SR, Reekie J, Holten B, Kalhauge A, Matthay MA, Lundgren JD, Helleberg M, Moestrup KS Association Between Shared Decision-Making During Family Meetings and Surrogates' Trust in Their ICU Physician. Lincoln TE, Buddadhumaruk P, Arnold RM, Scheunemann LP, Ernecoff NC, Chang CH, Carson SS, Hough CL, Curtis JR, Anderson W, Steingrub J, Peterson MW, Lo B, Matthay MA, White DB Reply to Khatun <i>et al.</i> Joffre J, Matthay MA, Hellman J Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19. Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT Opportunities for improved clinical trial designs in acute respiratory distress syndrome. Wick KD, Aggarwal NR, Curley MAQ, Fowler AA, Jaber S, Kostrubiec M, Lassau N, Laterre PF, Lebreton G, Levitt JE, Mebazaa A, Rubin E, Sinha P, Ware LB, Matthay MA The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19. ACTIV-3/TICO Study Group, Rogers AJ, Wentworth D, Phillips A, Shaw-Saliba K, Dewar RL, Aggarwal NR, Babiker AG, Chang W, Dharan NJ, Davey VJ, Higgs ES, Gerry N, Ginde AA, Hayanga JWA, Highbarger H, Highbarger JL, Jain MK, Kan V, Kim K, Lallemand P, Leshnower BG, Lutaakome JK, Matthews G, Mourad A, Mylonakis E, Natarajan V, Padilla ML, Pandit LM, Paredes R, Pett S, Ramachandruni S, Rehman MT, Sherman BT, Files DC, Brown SM, Matthay MA, Thompson BT, Neaton JD, Lane HC, Lundgren JD Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome. Wick KD, Matthay MA, Ware LB Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial. ACTIV-3/TICO Study Group, Barkauskas C, Mylonakis E, Poulakou G, Young BE, Vock DM, Siegel L, Engen N, Grandits G, Mosaly NR, Vekstein AM, Rogers R, Shehadeh F, Kaczynski M, Mylona EK, Syrigos KN, Rapti V, Lye DC, Hui DS, Leither L, Knowlton KU, Jain MK, Marines-Price R, Osuji A, Overcash JS, Kalomenidis I, Barmparessou Z, Waters M, Zepeda K, Chen P, Torbati S, Kiweewa F, Sebudde N, Almasri E, Hughes A, Bhagani SR, Rodger A, Sandkovsky U, Gottlieb RL, Nnakelu E, Trautner B, Menon V, Lutaakome J, Matthay M, Robinson P, Protopapas K, Koulouris N, Kimuli I, Baduashvili A, Braun DL, Günthard HF, Ramachandruni S, Kidega R, Kim K, Hatlen TJ, Phillips AN, Murray DD, Jensen TO, Padilla ML, Accardi EX, Shaw-Saliba K, Dewar RL, Teitelbaum M, Natarajan V, Laverdure S, Highbarger HC, Rehman MT, Vogel S, Vallée D, Crew P, Atri N, Schechner AJ, Pett S, Hudson F, Badrock J, Touloumi G, Brown SM, Self WH, North CM, Ginde AA, Chang CC, Kelleher A, Nagy-Agren S, Vasudeva S, Looney D, Nguyen HH, Sánchez A, Weintrob AC, Grund B, Sharma S, Reilly CS, Paredes R, Bednarska A, Gerry NP, Babiker AG, Davey VJ, Gelijns AC, Higgs ES, Kan V, Matthews G, Thompson BT, Legenne P, Chandra R, Lane HC, Neaton JD, Lundgren JD NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience. Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, Reuter J, Schultz MJ, Sharshar T, Shrestha GS, Verdonk C, Ware LB, Pirracchio R, Jabaudon M Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19. Casey JD, Beskow LM, Brown J, Brown SM, Gayat É, Ng Gong M, Harhay MO, Jaber S, Jentzer JC, Laterre PF, Marshall JC, Matthay MA, Rice TW, Rosenberg Y, Turnbull AE, Ware LB, Self WH, Mebazaa A, Collins SP Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD, ISPY COVID Adaptive Platform Trial Network, undefined Ventilatory Ratio Is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS. Siegel ER, Zhuo H, Sinha P, Papolos AI, Ni SA, Vessel K, Belzer A, Minus EB, Calfee CS, Matthay MA, Wick KD Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury. Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ Proceedings of the ISCT scientific signature series symposium, "Advances in cell and gene therapies for lung diseases and critical illnesses": International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021. Ting AE, Baker EK, Champagne J, Desai TJ, Dos Santos CC, Heijink IH, Itescu S, Le Blanc K, Matthay MA, McAuley DF, McIntyre L, Mei SHJ, Parekkadan B, Rocco PRM, Sheridan J, Thébaud B, Weiss DJ Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M Immediate myeloid depot for SARS-CoV-2 in the human lung. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR Mesenchymal Stromal Cell Extracellular Vesicles: A New Approach for Preventing Bronchopulmonary Dysplasia? Klinger JR, Matthay MA Immediate myeloid depot for SARS-CoV-2 in the human lung. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19. Wick KD, Siegel L, Neaton JD, Oldmixon C, Lundgren J, Dewar RL, Lane HC, Thompson BT, Matthay MA, ACTIV-3/TICO study group Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study. Nesseler N, Fadel G, Mansour A, Para M, Falcoz PE, Mongardon N, Porto A, Bertier A, Levy B, Cadoz C, Guinot PG, Fouquet O, Fellahi JL, Ouattara A, Guihaire J, Ruggieri VG, Gaudard P, Labaste F, Clavier T, Brini K, Allou N, Lacroix C, Chommeloux J, Lebreton G, Matthay MA, Provenchere S, Flécher E, Vincentelli A, ECMOSARS Investigators Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021). Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages. Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates. Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome. Mahida RY, Price J, Lugg ST, Li H, Parekh D, Scott A, Harrison P, Matthay MA, Thickett DR Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM A decoy mutant ACE2 designed to reduce COVID-19. Maishan M, Lim DL, Zimmerman GA, Matthay MA Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis. Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA Functional Outcomes and Morbidity in Pediatric Sepsis Survivors: A Tanzanian Experience. Lau-Braunhut SA, Smith AM, Steurer MA, Murray BL, Sawe H, Matthay MA, Reynolds T, Kortz TB Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges. Masterson CH, Ceccato A, Artigas A, Dos Santos C, Rocco PR, Rolandsson Enes S, Weiss DJ, McAuley D, Matthay MA, English K, Curley GF, Laffey JG Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD Cell Therapy with the Cell or without the Cell for Premature Infants?: Time Will Tell. Thébaud B, Matthay MA Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury? Leligdowicz A, Matthay MA Delayed Presentation and Mortality in Children With Sepsis in a Public Tertiary Care Hospital in Tanzania. Smith AM, Sawe HR, Matthay MA, Murray BL, Reynolds T, Kortz TB Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL, COMET Consortium, Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR Promises and challenges of personalized medicine to guide ARDS therapy. Wick KD, McAuley DF, Levitt JE, Beitler JR, Annane D, Riviello ED, Calfee CS, Matthay MA Intravenous immunoglobulin therapy for COVID-19 ARDS. Wilfong EM, Matthay MA Molecular programs of fibrotic change in aging human lung. Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice. Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome. Lim MJ, Zinter MS, Chen L, Wong KMY, Bhalla A, Gala K, Guglielmo M, Alkhouli M, Huard LL, Hanudel MR, Vangala S, Schwingshackl A, Matthay M, Sapru A Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells. Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ Environmental Factors. Wick KD, Matthay MA Preface. Matthay MA, Liu KD Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome. Mahida RY, Scott A, Parekh D, Lugg ST, Belchamber KBR, Hardy RS, Matthay MA, Naidu B, Thickett DR Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs. Zhang X, Sugita S, Liu A, Naito Y, Hwang W, Qiu H, Sakamoto A, Sawa T, Matthay MA, Lee JW Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis. Mahida RY, Scott A, Parekh D, Lugg ST, Hardy RS, Lavery GG, Matthay MA, Naidu B, Perkins GD, Thickett DR Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? Matthay MA, Luetkemeyer AF Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Monteiro ACC, Flori H, Dahmer MK, Sim MS, Quasney MW, Curley MAQ, Matthay MA, Sapru A, BALI Study Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Networ Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids. Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial. Quraishi SA, Bhan I, Matthay MA, Thompson BT, Camargo CA, Bajwa EK Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS. Wick KD, Leligdowicz A, Zhuo H, Ware LB, Matthay MA Readmission following both cardiac and non-cardiac acute dyspnoea is associated with a striking risk of death. Cerlinskaite K, Mebazaa A, Cinotti R, Matthay M, Wussler DN, Gayat E, Juknevicius V, Kozhuharov N, Dinort J, Michou E, Gualandro DM, Paleviciute E, Alitoit-Marrote I, Kablucko D, Bagdonaite L, Balciunas M, Vaiciuliene D, Jonauskiene I, Motiejunaite J, Stašaitis K, Kukulskis A, Damalakas Š, Laucevicius A, Mueller C, Kavoliuniene A, Celutkiene J, GREAT network SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression. Zhao R, Su Z, Komissarov AA, Liu SL, Yi G, Idell S, Matthay MA, Ji HL The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included? Matthay MA, Thompson BT, Ware LB Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome. Mac Sweeney R, Reddy K, Davies JC, Parker M, Kelly B, Elborn JS, Conlon J, Verghis RM, Calfee CS, Matthay MA, Alton EWFW, McAuley DF Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis. Lee JS, La J, Aziz S, Dobrinskikh E, Brownell R, Jones KD, Achtar-Zadeh N, Green G, Elicker BM, Golden JA, Matthay MA, Kukreja J, Schwartz DA, Wolters PJ Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice. Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE The ARREST Pneumonia Clinical Trial. Rationale and Design. Levitt JE, Festic E, Desai M, Hedlin H, Mahaffey KW, Rogers AJ, Gajic O, Matthay MA, ARREST Pneumonia Clinical Trial Investigators The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury. Zinter MS, Lindemans CA, Versluys BA, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade. Ali G, Zhang M, Zhao R, Jain KG, Chang J, Komatsu S, Zhou B, Liang J, Matthay MA, Ji HL Global absence and targeting of protective immune states in severe COVID-19. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome. Matthay MA, Leligdowicz A, Liu KD Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome. Matthay MA, Wick KD Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM, National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Steingrub J, Smithline H, Tiru B, Tidswell M, Kozikowski L, Thornton-Thompson S, De Souza L, Hou P, Baron R, Massaro A, Aisiku I, Fredenburgh L, Seethala R, Johnsky L, Riker R, Seder D, May T, Baumann M, Eldridge A, Lord C, Shapiro N, Talmor D, O’Mara T, Kirk C, Harrison K, Kurt L, Schermerhorn M, Banner-Goodspeed V, Boyle K, Dubosh N, Filbin M, Hibbert K, Parry B, Lavin-Parsons K, Pulido N, Lilley B, Lodenstein C, Margolin J, Brait K, Jones A, Galbraith J, Peacock R, Nandi U, Wachs T, Matthay M, Liu K, Kangelaris K, Wang R, Calfee C, Yee K, Hendey G, Chang S, Lim G, Qadir N, Tam A, Beutler R, Levitt J, Wilson J, Rogers A, Vojnik R, Roque J, Albertson T, Chenoweth J, Adams J, Pearson S, Juarez M, Almasri E, Fayed M, Hughes A, Hillard S, Huebinger R, Wang H, Vidales E, Patel B, Ginde A, Moss M, Baduashvili A, McKeehan J, Finck L, Higgins C, Howell M, Douglas I, Haukoos J, Hiller T, Lyle C, Cupelo A, Caruso E, Camacho C, Gravitz S, Finigan J, Griesmer C, Park P, Hyzy R, Nelson K, McDonough K, Olbrich N, Williams M, Kapoor R, Nash J, Willig M, Ford H, Gardner-Gray J, Ramesh M, Moses M, Ng Gong M, Aboodi M, Asghar A, Amosu O, Torres M, Kaur S, Chen JT, Hope A, Lopez B, Rosales K, Young You J, Mosier J, Hypes C, Natt B, Borg B, Salvagio Campbell E, Hite RD, Hudock K, Cresie A, Alhasan F, Gomez-Arroyo J, Duggal A, Mehkri O, Hastings A, Sahoo D, Abi Fadel F, Gole S, Shaner V, Wimer A, Meli Y, King A, Terndrup T, Exline M, Pannu S, Robart E, Karow S, Hough C, Robinson B, Johnson N, Henning D, Campo M, Gundel S, Seghal S, Katsandres S, Dean S, Khan A, Krol O, Jouzestani M, Huynh P, Weissman A, Yealy D, Scholl D, Adams P, McVerry B, Huang D, Angus D, Schooler J, Moore S, Files C, Miller C, Gibbs K, LaRose M, Flores L, Koehler L, Morse C, Sanders J, Langford C, Nanney K, MdalaGausi M, Yeboah P, Morris P, Sturgill J, Seif S, Cassity E, Dhar S, de Wit M, Mason J, Goodwin A, Hall G, Grady A, Chamberlain A, Brown S, Bledsoe J, Leither L, Peltan I, Starr N, Fergus M, Aston V, Montgomery Q, Smith R, Merrill M, Brown K, Armbruster B, Harris E, Middleton E, Paine R, Johnson S, Barrios M, Eppensteiner J, Limkakeng A, McGowan L, Porter T, Bouffler A, Leahy JC, deBoisblanc B, Lammi M, Happel K, Lauto P, Self W, Casey J, Semler M, Collins S, Harrell F, Lindsell C, Rice T, Stubblefield W, Gray C, Johnson J, Roth M, Hays M, Torr D, Zakaria A, Schoenfeld D, Thompson T, Hayden D, Ringwood N, Oldmixon C, Ulysse C, Morse R, Muzikansky A, Fitzgerald L, Whitaker S, Lagakos A, Brower R, Reineck L, Aggarwal N, Bienstock K, Freemer M, Maclawiw M, Weinmann G, Morrison L, Gillespie M, Kryscio R, Brodie D, Zareba W, Rompalo A, Boeckh M, Parsons P, Christie J, Hall J, Horton N, Zoloth L, Dickert N, Diercks D Alternative Tobacco Product Use in Critically Ill Patients. Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS Phenotypes and personalized medicine in the acute respiratory distress syndrome. Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies. Ware LB, Matthay MA, Mebazaa A Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties. Matthay MA, Thompson BT Global Absence and Targeting of Protective Immune States in Severe COVID-19. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Global Absence and Targeting of Protective Immune States in Severe COVID-19. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury. Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation. Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung. Leligdowicz A, Ross JT, Nesseler N, Matthay MA Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression. Ji HJ, Su Z, Zhao R, Komissarov AA, Yi G, Liu SL, Idell S, Matthay MA Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Is a "Cytokine Storm" Relevant to COVID-19? Sinha P, Matthay MA, Calfee CS Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA Need for Additional Trials of Vitamin C for Sepsis. Files DC, Liu KD, Matthay M Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure. Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep. Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome. Mahida RY, Matsumoto S, Matthay MA The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect. Kohne JG, Dahmer MK, Weeks HM, Kaciroti N, Quasney MW, Sapru A, Curley MAQ, Matthay M, Flori H Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels. Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life. Block BL, Jeon SY, Sudore RL, Matthay MA, Boscardin WJ, Smith AK The potential of lipid mediator networks as ocular surface therapeutics and biomarkers. Flitter BA, Fang X, Matthay MA, Gronert K Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. Dahmer MK, Flori H, Sapru A, Kohne J, Weeks HM, Curley MAQ, Matthay MA, Quasney MW, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M, ESICM Translational Biology Group of the Acute Respiratory Failure section Gender Differences in Authorship of Critical Care Literature. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Ji HL, Zhao R, Matalon S, Matthay MA Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS Treatment for severe acute respiratory distress syndrome from COVID-19. Matthay MA, Aldrich JM, Gotts JE Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study. Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults. Hendrickson CM, Matthay MA Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Harhay MO, Casey JD, Clement M, Collins SP, Gayat É, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials. Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome. Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ The authors reply. Rogers AJ, Desai M, Matthay MA, Choi AM, Baron RM Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs. Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene. Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie HG, Chang Y, Zhang M, Liu Y, Jain K, Jung BG, Samten B, Jiang D, Liang J, Ikebe M, Matthay MA, Ji HL Lung inflammatory environments differentially alter mesenchymal stromal cell behavior. Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome. Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs. White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome. Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM The Continued Need for Clinical Trials in Deceased Organ Donor Management. Niemann CU, Matthay MA, Ware LB The ex vivo human lung: research value for translational science. Ross JT, Nesseler N, Lee JW, Ware LB, Matthay MA Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA Pathogenesis of Acute Respiratory Distress Syndrome. Huppert LA, Matthay MA, Ware LB Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units. Scheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome? Lee JW, Matthay MA A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome. Flori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK, BALI and RESTORE Study Investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Could Decisions to Limit Treatment Contribute to Mortality Differences between Patients with Different Presepsis Trajectories? Block BL, Matthay M Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS The authors reply. Fielding-Singh V, Matthay MA, Calfee CS The authors reply. Fielding-Singh V, Matthay MA, Calfee CS Acute respiratory distress syndrome. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS Heterogeneity in sepsis: new biological evidence with clinical applications. Leligdowicz A, Matthay MA AIMing Immunomodulation Therapy at Sepsis. Leligdowicz A, Matthay MA Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M, The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (P Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A ECMO in severe acute respiratory distress syndrome. Matthay MA Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome. Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Fielding-Singh V, Matthay MA, Calfee CS Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. Huppert LA, Liu KD, Matthay MA Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS, NHLBI ARDS Network Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. Mi MY, Matthay MA, Morris AH Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J Possible hepatotoxicity of IQOS. Chun L, Moazed F, Matthay M, Calfee C, Gotts J Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury. Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia. Park J, Kim S, Lim H, Liu A, Hu S, Lee J, Zhuo H, Hao Q, Matthay MA, Lee JW Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF, Irish Critical Care Trials Group Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ. Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome. Kallet RH, Ho K, Lipnick MS, Matthay MA Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials. Pais FM, Sinha P, Liu KD, Matthay MA A psychometric study of the decisional conflict scale in surrogate decision makers. Pecanac KE, Brown RL, Steingrub J, Anderson W, Matthay MA, White DB Secondary peritonitis: principles of diagnosis and intervention. Ross JT, Matthay MA, Harris HW Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB Mesenchymal stromal cells and macrophages in sepsis: new insights. Kotas ME, Matthay MA Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study- Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Hendrickson CM, Matthay MA Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution. Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH Cell-based Therapy in Sepsis. A Step Closer. Gotts JE, Matthay MA Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S Exosome-based Therapy for Bronchopulmonary Dysplasia. Matthay MA, Abman SH Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions. Fang X, Matthay MA Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania. Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration. Ding Y, Zhao R, Zhao X, Matthay MA, Nie HG, Ji HL Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications. Matthay MA Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, PALISI PICFlu Investigators, Hertz T, Randolph AG Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries. Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Laffey JG, Matthay MA Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction. Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Crouser ED, Matthay MA Inhalation therapies in acute respiratory distress syndrome. Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS. Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay MA External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB Clinical trials in acute respiratory distress syndrome: challenges and opportunities. Matthay MA, McAuley DF, Ware LB Pulmonary toxicity of e-cigarettes. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial. McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF Understanding blood gas analysis. Gattinoni L, Pesenti A, Matthay M Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA, Su X Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Huppert LA, Matthay MA Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset. Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, NHLBI ARDS Network Protein biomarkers associated with primary graft dysfunction following lung transplantation. Hamilton BC, Kukreja J, Ware LB, Matthay MA Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Matthay MA, Pati S, Lee JW Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Matthay MA, Beitler JR Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? Moore PK, Matthay MA What drives neutrophils to the alveoli in ARDS? Zemans RL, Matthay MA Cathepsin L Helps to Defend Mice from Infection with Influenza A. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH Challenges in predicting which patients will develop ARDS. Matthay MA A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR IL1RL1 asthma risk variants regulate airway type 2 inflammation. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network The authors reply. Kangelaris KN, Ware LB, Matthay MA, Calfee CS The authors reply. Kangelaris KN, Ware LB, Matthay MA, Calfee CS miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D A new experimental model of acid- and endotoxin-induced acute lung injury in rats. Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A The acute respiratory distress syndrome following isolated severe traumatic brain injury. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network Sepsis: pathophysiology and clinical management. Gotts JE, Matthay MA Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD Negative-Pressure Pulmonary Edema. Bhattacharya M, Kallet RH, Ware LB, Matthay MA Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ Diagnostic workup for ARDS patients. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs. Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay MA, Anderson WG, Peterson MW, Steingrub JS, Arnold RM, White DB Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema. Walter JM, Matthay MA, Gillespie CT, Corbridge T New Strategies for Effective Therapeutics in Critically Ill Patients. Matthay MA, Liu KD Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS Acute cor pulmonale and the acute respiratory distress syndrome. Guérin C, Matthay MA Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Matthay MA, Ware LB Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D Saving lives with high-flow nasal oxygen. Matthay MA Sedation protocol for critically ill pediatric patients--reply. Curley MA, Wypij D, Matthay MA, RESTORE Study Investigators Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation. Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Lee JW Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Wilson J, McKenna D, Liu KD, Matthay MA Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Matthay MA Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units. Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA, RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA Body temperature and mortality in patients with acute respiratory distress syndrome. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Hendrickson CM, Crestani B, Matthay MA Biomarkers to exclude the diagnosis of ventilator-associated pneumonia. Matthay MA Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Walter J, Ware LB, Matthay MA Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Gotts JE, Matthay MA Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network Is there a need for emerging drugs for the acute respiratory distress syndrome? Fitzgerald M, McAuley DF, Matthay M Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS, California Transplant Donor Network Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Gotts JE, Abbott J, Matthay MA Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction. Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group Translational studies in the ex vivo human lung. Sakuma T, Matthay MA Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P Resolution of pulmonary edema. Thirty years of progress. Matthay MA Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation. McKenna D, Matthay MA, Pati S Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, NHLBI ARDS Network Rosuvastatin for sepsis-associated acute respiratory distress syndrome. National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. Wilson JG, Matthay MA Applying metabolomics to uncover novel biology in ARDS. Rogers AJ, Matthay MA Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA, California Transplant Donor Network Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ Metabolomic derangements are associated with mortality in critically ill adult patients. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significanc Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN TGF-β and lung fluid balance in ARDS. Frank JA, Matthay MA Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA, National Heart Lung and Blood Institute ARDS Network Investigators Treating ARDS: new hope for a tough problem. Gotts JE, Matthay MA Cystic fibrosis epithelial cell and bacterial binding. Engel J, Matthay M Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL, National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome Network Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Hendrickson CM, Matthay MA Acute cor pulmonale in ARDS. Vieillard-Baron A, Price LC, Matthay MA Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Toonkel RL, Hare JM, Matthay MA, Glassberg MK Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. Glassberg MK, Hare JM, Toonkel RL, Matthay MA Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN Cell therapy for lung disease: a step forward. Gotts JE, Matthay MA The acute respiratory distress syndrome in 2013. Matthay MA, Song Y, Bai C, Jones KD HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1. Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. Thompson BT, Matthay MA The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. Seeley EJ, Rosenberg P, Matthay MA Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF Risk factors and outcomes in transfusion-associated circulatory overload. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Schultz MJ, Juffermans NP, Matthay MA Cecal ligation model of sepsis in mice: new insights. Bastarache JA, Matthay MA Hyperoxic acute lung injury. Kallet RH, Matthay MA Regulation and repair of the alveolar-capillary barrier in acute lung injury. Bhattacharya J, Matthay MA IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD The acute respiratory distress syndrome. Matthay MA, Ware LB, Zimmerman GA The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Zeyed YF, Bastarache JA, Matthay MA, Ware LB Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Levitt JE, Matthay MA Inflection points in sepsis biology: from local defense to systemic organ injury. Seeley EJ, Matthay MA, Wolters PJ Cell-based therapy for acute lung injury: are we there yet? Lee JW, Zhu Y, Matthay MA Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA, NHLBI ARDS Network The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D Progress in modelling acute lung injury in a pre-clinical mouse model. Matthay MA, Howard JP Mesenchymal stem cells and the stem cell niche: a new chapter. Gotts JE, Matthay MA Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA, DOGMATIC Study Investigators Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated? Kallet RH, Alonso JA, Matthay MA Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA, California Transplant Donor Network Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H, Trauma ALI SNP Consortium (TASC) investigators Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD, National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress S Transfusion-related acute lung injury: incidence and risk factors. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome. Matthay MA, Kallet RH Acute lung failure. Mac Sweeney R, McAuley DF, Matthay MA Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT Physiology, reductionism, and translational medicine: the right mix. Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevens T, Ware LB Clinical review: Thinking outside the box--an iconoclastic view of current practice. Singer M, Matthay MA Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA, California Transplant Donor Network Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA Mesenchymal stem cells and acute lung injury. Gotts JE, Matthay MA An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM, Acute Lung Injury in Animals Study Group Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Matthay MA, Liu KD Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay MA, Kallet RH Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Cross LJ, Matthay MA Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA, National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, NIH NHLBI ARDS Network Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA Informed consent in research to improve the number and quality of deceased donor organs. Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA, DOGMATIC Study Investigators Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Yamakawa N, Uchida T, Matthay MA, Makita K Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS The acute respiratory distress syndrome: pathogenesis and treatment. Matthay MA, Zemans RL Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA Stem cells in sepsis and acute lung injury. Cribbs SK, Matthay MA, Martin GS The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition. Levitt JE, Matthay MA Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Lee JS, Su X, Rackley C, Matthay MA, Gupta N Mesenchymal stem cells for acute lung injury: preclinical evidence. Matthay MA, Goolaerts A, Howard JP, Lee JW Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW Thinking outside the box: Introduction. Singer M, Matthay MA The influence of race on the development of acute lung injury in trauma patients. Brown LM, Kallet RH, Matthay MA, Dicker RA Pathophysiology of transfusion-related acute lung injury. Looney MR, Gilliss BM, Matthay MA Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD Assessing the quantity of pulmonary edema in critically ill children. McAuley DF, Brown LM, Matthay MA Advances and challenges in translating stem cell therapies for clinical diseases. Matthay MA Alveolar fluid clearance is faster in women with acute lung injury compared to men. Bastarache JA, Ong T, Matthay MA, Ware LB Acute lung injury: epidemiology, pathogenesis, and treatment. Johnson ER, Matthay MA Acute respiratory distress syndrome after surgery: can the risk be decreased? Matthay MA, Jayr C Therapeutic strategies for severe acute lung injury. Diaz JV, Brower R, Calfee CS, Matthay MA Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. Fang X, Neyrinck AP, Matthay MA, Lee JW Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR Update on acute lung injury and critical care medicine 2009. Matthay MA, Idell S Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS Regulated gene expression in cultured type II cells of adult human lung. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF Simulation of lung alveolar epithelial wound healing in vitro. Kim SH, Matthay MA, Mostov K, Hunt CA Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF Clinical immunology: Culprits with evolutionary ties. Calfee CS, Matthay MA Standards and recommendations for quantitative assessment of lung structure in research. Matthay MA Measuring the quantity of pulmonary edema in clinical lung injury. Brown LM, Matthay MA Thirty years of critical care medicine. Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Abman SH, Matthay MA Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. Su X, Matthay MA, Malik AB Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, NHLBI ARDS Clinical Trials Network Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Sapru A, Curley MA, Brady S, Matthay MA, Flori H Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA Potential application of mesenchymal stem cells in acute lung injury. Lee JW, Gupta N, Serikov V, Matthay MA Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Brown LM, Liu KD, Matthay MA Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. McAuley DF, Matthay MA Inhaled activated protein C: a novel therapy for acute lung injury? Liu KD, Looney MR, Matthay MA Protective mechanisms of activated protein C in severe inflammatory disorders. Neyrinck AP, Liu KD, Howard JP, Matthay MA 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Church GD, Matthay MA, Liu K, Milet M, Flori HR Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD Recent trends in acute lung injury mortality: 1996-2005. Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD, NIH NHLBI ARDS Network Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Su X, Looney MR, Gupta N, Matthay MA Mesenchymally "stemming" angiogenesis. Matthay MA Neutrophil sandwiches injure the microcirculation. Looney MR, Matthay MA Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Su X, Matthay MA Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF A computational approach to understand in vitro alveolar morphogenesis. Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA The pathogenetic and prognostic value of biologic markers in acute lung injury. Levitt JE, Gould MK, Ware LB, Matthay MA Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Neyrinck AP, Matthay MA Racial and ethnic disparities in mortality from acute lung injury. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD, National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress S Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA Beyond fishing: the role of discovery proteomics in mechanistic lung research. Ware LB, Matthay MA Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Looney MR, Esmon CT, Matthay MA Reasons for nonenrollment in a clinical trial of acute lung injury. Glassberg AE, Luce JM, Matthay MA, National Heart, Lung, and Blood Institute Clinical Trials Network Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA, NHLBI ARDS Network Predictors of mortality in acute lung injury during the era of lung protective ventilation. Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH Randomized clinical trial of activated protein C for the treatment of acute lung injury. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA Novel molecular strategy to prevent pulmonary edema. Matthay MA, Berthiaume Y Measurement of extravascular lung water in patients with pulmonary edema. Matthay MA Protein C as a surrogate end-point for clinical trials of sepsis. Liu KD, Matthay MA Treatment of acute lung injury: clinical and experimental studies. Matthay MA Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Matthay MA, Calfee CS Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA A framework and mechanistically focused, in silico method for enabling rational translational research. Hunt CA, Baranzini S, Matthay MA, Park S Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Matthay MA, Lee J Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF Advances in critical care for the nephrologist: acute lung injury/ARDS. Liu KD, Matthay MA Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA The role of protein C in sepsis. Looney MR, Matthay MA Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, Acute Respiratory Distress Syndrome Network, National Heart, Lung, and Blood Institute Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Frank JA, Pittet JF, Wray C, Matthay MA Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA Surfactant treatment of aspiration-induced lung injury in children. Matthay MA, Taeusch W Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Networ Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC Pulmonary barriers to pneumonia and sepsis. Matthay MA, Su X Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA Alveolar edema fluid clearance and acute lung injury. Berthiaume Y, Matthay MA Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM Genomics and proteomics of lung disease: conference summary. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Fremont RD, Kallet RH, Matthay MA, Ware LB Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Flori HR, Ware LB, Milet M, Matthay MA Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K Nonventilatory treatments for acute lung injury and ARDS. Calfee CS, Matthay MA Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Frank JA, Parsons PE, Matthay MA Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF Protein permeability in lung injury: now in real time again? Lee JW, Matthay MA Treatment of acute lung injury: historical perspective and potential future therapies. Levitt JE, Matthay MA Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Wiener-Kronish JP, Matthay MA Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Gupta N, Matthay MA Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA Higher urine desmosine levels are associated with mortality in patients with acute lung injury. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network Integrating acute lung injury and regulation of alveolar fluid clearance. Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA Evolving practices in critical care and potential implications for management of acute kidney injury. Liu KD, Matthay MA, Chertow GM Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA Animal models of transfusion-related acute lung injury. Looney MR, Matthay MA Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. Cepkova M, Matthay MA Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA Perspectives, translational research, and letters to the editor. Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB Alveolar epithelial ion and fluid transport: recent progress. Folkesson HG, Matthay MA Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL, Pediatric Prone Positioning Study Group Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Matthay MA, Abraham E Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Looney MR, Matthay MA Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Cepkova M, Brady S, Sapru A, Matthay MA, Church G Clinical practice. Acute pulmonary edema. Ware LB, Matthay MA TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Su X, Robriquet L, Folkesson HG, Matthay MA Therapeutic value of a lung protective ventilation strategy in acute lung injury. Matthay MA, Calfee CS Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Matthay MA, Zimmerman GA High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA Leukotrienes in acute lung injury: a potential therapeutic target? Frank JA, Matthay MA Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA Recent advances in mechanical ventilation. Calfee CS, Matthay MA Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Kallet RH, Daniel BM, Garcia O, Matthay MA Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA Critical care in AJRCCM 2004. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA, Acute Respiratory Distress Syndrome Network Alveolar epithelium: role in lung fluid balance and acute lung injury. Matthay MA, Robriquet L, Fang X Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? McAuley DF, Matthay MA Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Flori HR, Glidden DV, Rutherford GW, Matthay MA Integrated control of lung fluid balance. Mehta D, Bhattacharya J, Matthay MA, Malik AB HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF Can nicotine treat sepsis? Matthay MA, Ware LB Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Parsons PE, Matthay MA, Ware LB, Eisner MD, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network Acute lung injury and acute respiratory distress syndrome in pregnancy. Bandi VD, Munnur U, Matthay MA Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Su X, Looney M, Robriquet L, Fang X, Matthay MA Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Kallet RH, Alonso JA, Pittet JF, Matthay MA Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT, National Heart, Lung, and Blood Institute ARDS Clinical Trials Network Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Sue RD, Matthay MA, Ware LB Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. McAuley DF, Frank JA, Fang X, Matthay MA Coagulation-dependent mechanisms and asthma. Matthay MA, Clements JA Proteomics: current techniques and potential applications to lung disease. Hirsch J, Hansen KC, Burlingame AL, Matthay MA Transfusion-related acute lung injury: a review. Looney MR, Gropper MA, Matthay MA Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Zemans RL, Matthay MA Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA Plasma protein C levels in patients with acute lung injury: prognostic significance. Matthay MA, Ware LB H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC Mechanisms of alveolar protein clearance in the intact lung. Hastings RH, Folkesson HG, Matthay MA Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Zemans RL, Chatterjee K, Matthay MA Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Fang X, Song Y, Zemans R, Hirsch J, Matthay MA Malnutrition impairs alveolar fluid clearance in rat lungs. Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA Look before you leap: how do intensivists improve care for critically ill patients? Gropper MA, Matthay MA Why does acute lung injury have no impact on mortality in patients with major trauma? McClintock DE, Matthay MA Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Krupa A, Kato H, Matthay MA, Kurdowska AK Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN Cytokine-mediated inflammation in acute lung injury. Goodman RB, Pugin J, Lee JS, Matthay MA Pancreatitis-associated acute lung injury: new insights. Pastor CM, Matthay MA, Frossard JL Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport. Clerici C, Matthay MA Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury. Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay MA, Christensen PJ Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D, ARDS Clinical Trials Network, National Heart, Lung, and Blood Institute, National Institutes of Heal Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Eisner MD, Parsons P, Matthay MA, Ware L, Greene K, Acute Respiratory Distress Syndrome Network Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA Acute lung injury and the acute respiratory distress syndrome. Cheng IW, Matthay MA Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S Pulmonary edema fluid antioxidants are depressed in acute lung injury. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs. Olman MA, Matthay MA Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Flori HR, Ware LB, Glidden D, Matthay MA Protein C and thrombomodulin in human acute lung injury. Ware LB, Fang X, Matthay MA Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL Therapeutic strategies to hasten the resolution of pulmonary edema. Folkesson HG, Matthay MA Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Collard HR, Saint S, Matthay MA Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA Prognostic value of surfactant proteins A and D in patients with acute lung injury. Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA Alveolar fluid clearance in patients with ARDS: does it make a difference? Matthay MA Clinical measurement of pulmonary edema. Matthay MA Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. Berthiaume Y, Folkesson HG, Matthay MA Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Brower RG, Matthay M, Schoenfeld D Alveolar epithelial fluid transport in acute lung injury: new insights. Sartori C, Matthay MA Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA Measuring microvascular blood flow in sepsis--a continuing challenge. Ware LB, Matthay MA Science review: mechanisms of ventilator-induced injury. Frank JA, Matthay MA Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. Planès C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C Central line infections. Lane RK, Matthay MA Invited review: Active fluid clearance from the distal air spaces of the lung. Matthay MA, Clerici C, Saumon G Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs. Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay MA Ventilator-induced lung injury: in vivo and in vitro mechanisms. Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS Assessment of lungs rejected for transplantation and implications for donor selection. Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M The pulmonary epithelium is an important mediator of ventilator-induced lung injury. Matthay MA Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. Fang X, Yang B, Matthay MA, Verkman AS Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB Lung epithelial fluid transport and the resolution of pulmonary edema. Matthay MA, Folkesson HG, Clerici C Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Saint S, Savel RH, Matthay MA Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Ware LB, Matthay MA The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Atabai K, Matthay MA Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA, Acute Respiratory Distress Syndrome Network Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome. Matthay MA, Uchida T, Fang X Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines. Folkesson HG, Matthay MA, Chapin CJ, Porta NF, Kitterman JA Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA Novel role for CFTR in fluid absorption from the distal airspaces of the lung. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Ware LB, Conner ER, Matthay MA Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS. Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Oswari J, Matthay MA, Margulies SS Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB The Role of Protein C in Sepsis. Looney MR, Matthay MA Treatment of ARDS. Brower RG, Ware LB, Berthiaume Y, Matthay MA Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA, Acute Respiratory Distress Syndrome Network Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis. Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium. Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS TGF-beta is a critical mediator of acute lung injury. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Ware LB, Matthay MA Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats. Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties. Matthay MA Alveolar epithelial transport. Basic science to clinical medicine. Crandall ED, Matthay MA Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs. Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Kurihara T, Matthay MA Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Yost CS, Matthay MA, Gropper MA Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema. Sartori C, Matthay MA, Scherrer U Interleukin-1beta augments in vitro alveolar epithelial repair. Geiser T, Jarreau PH, Atabai K, Matthay MA Role of aquaporin water channels in pleural fluid dynamics. Song Y, Yang B, Matthay MA, Ma T, Verkman AS Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. Frank JA, Wang Y, Osorio O, Matthay MA Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies. Fukuda N, Folkesson HG, Matthay MA Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Frank JA, Nuckton TJ, Matthay MA Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly. Jasmer RM, Matthay MA Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs. Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA The acute respiratory distress syndrome. Ware LB, Matthay MA Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A Aquaporin water channels and lung physiology. Verkman AS, Matthay MA, Song Y Hypoxia regulates gene expression of alveolar epithelial transport proteins. Clerici C, Matthay MA [Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin]. Coscoy S, de Weille J, Lingueglia E, Fukuda N, Matthay M, Lazdunski M, Barbry P Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV A novel alveolar type I cell-specific biochemical marker of human acute lung injury. Newman V, Gonzalez RF, Matthay MA, Dobbs LG Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation. Pascual FE, Matthay MA, Bacchetti P, Wachter RM Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development. Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF Lung fluid transport in aquaporin-5 knockout mice. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS Noninvasive ventilation for acute respiratory failure. Jasmer RM, Matthay MA Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. Song Y, Ma T, Matthay MA, Verkman AS Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy. Kallet RH, Alonso JA, Luce JM, Matthay MA Health-related quality of life after acute lung injury. Eisner MD, Matthay MA Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits. Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM Interobserver variability in applying a radiographic definition for ARDS. Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. Verghese GM, Ware LB, Matthay BA, Matthay MA The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages. Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats. Berthiaume Y, Folkesson HG, Matthay MA Oxidant-mediated lung injury in the acute respiratory distress syndrome. Matthay MA, Geiser T, Matalon S, Ischiropoulos H Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms. Wang Y, Jayr C, Folkesson HG, Matthay MA Conference summary: acute lung injury. Matthay MA Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance. Conner ER, Ware LB, Modin G, Matthay MA HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Newman V, Gonzalez R, Matthay M, Dobbs L Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock. Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Ware LB, Golden JA, Finkbeiner WE, Matthay MA The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Pugin J, Verghese G, Widmer MC, Matthay MA Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep. Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection. Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS Role of collagenase in mediating in vitro alveolar epithelial wound repair. Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP Risk reduction in the intensive care unit. Saint S, Matthay MA Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Matthay MA, Flori HR, Conner ER, Ware LB Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA Protective ventilation for the acute respiratory distress syndrome. Parsons PE, Matthay M A mouse model to test the in vivo efficacy of chemical chaperones. Bai C, Biwersi J, Verkman AS, Matthay MA Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung. Sakuma T, Takahashi K, Ohya N, Nakada T, Matthay MA Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Ma T, Yang B, Matthay MA, Verkman AS New in situ mouse model to quantify alveolar epithelial fluid clearance. Garat C, Carter EP, Matthay MA High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Carter EP, Olveczky BP, Matthay MA, Verkman AS The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome. Matthay MA, Pittet JF, Jayr C Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung. Carter EP, Umenishi F, Matthay MA, Verkman AS Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Chesnutt AN, Matthay MA, Tibayan FA, Clark JG Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats. Modelska K, Matthay MA, McElroy MC, Pittet JF Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. Folkesson HG, Matthay MA Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Jasmer RM, Luce JM, Matthay MA Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats. Garat C, Meignan M, Matthay MA, Luo DF, Jayr C Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Smith WS, Matthay MA Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Oliver BL, Garat C, Pytela R, Matthay MA Biological markers of acute lung injury: prognostic and pathogenetic significance. Pittet JF, Mackersie RC, Martin TR, Matthay MA Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis. Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA Sharp increase in rat lung water channel expression in the perinatal period. Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Miller EJ, Cohen AB, Matthay MA Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. Carter EP, Matthay MA, Farinas J, Verkman AS Acid aspiration induced lung injury. New insights and therapeutic options. Matthay MA, Rosen GD Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats. Pittet JF, Brenner TJ, Modelska K, Matthay MA Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats. Folkesson HG, Pittet JF, Nitenberg G, Matthay MA The acute respiratory distress syndrome. Matthay MA Alveolar epithelial clearance of protein. Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia. Sakuma T, Suzuki S, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA Pulmonary edema in a woman following fetal surgery. DiFederico EM, Harrison M, Matthay MA Salt and water transport across alveolar and distal airway epithelia in the adult lung. Matthay MA, Folkesson HG, Verkman AS Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. Folkesson HG, Matthay MA, Frigeri A, Verkman AS Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM Alveolar endotoxin increases alveolar liquid clearance in rats. Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay MA, Jayr C Identification of patients with acute lung injury. Predictors of mortality. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA Cellular uptake of albumin from lungs of anesthetized rabbits. Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. Folkesson HG, Matthay MA, Hébert CA, Broaddus VC Evaluation of definitions of ARDS. Rubenfeld GD, Doyle RL, Matthay MA Resistance of the alveolar epithelium to injury from septic shock in sheep. Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Schwartz DE, Matthay MA, Cohen NH Frequency and importance of barotrauma in 100 patients with acute lung injury. Schnapp LM, Chin DP, Szaflarski N, Matthay MA Fibrosing alveolitis in the adult respiratory distress syndrome. Matthay MA The effect of salt water on alveolar epithelial barrier function. Folkesson HG, Kheradmand F, Matthay MA Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA Alveolar fluid clearance in the resected human lung. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA Alveolar liquid and protein clearance in anesthetized ventilated rats. Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA Function of the alveolar epithelial barrier under pathologic conditions. Matthay MA Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Kelly BJ, Matthay MA Alveolar epithelial barrier and acute lung injury. Matthay MA, Folkesson HG, Campagna A, Kheradmand F Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. Serikov VB, Grady M, Matthay MA Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. Sakuma T, Pittet JF, Jayr C, Matthay MA Clearance of different-sized proteins from the alveolar space in humans and rabbits. Hastings RH, Grady M, Sakuma T, Matthay MA Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Espiritu RF, Pittet JF, Matthay MA, Goetzl EJ Pulmonary edema associated with salt water near-drowning: new insights. Cohen DS, Matthay MA, Cogan MG, Murray JF Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay MA Obstetric patients requiring critical care. A five-year review. Kilpatrick SJ, Matthay MA Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Callaham M, Barton C, Matthay M Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. Jayr C, Matthay MA Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. Wiener-Kronish JP, Albertine KH, Matthay MA Critical care medicine. Matthay MA, Matthay RA Alveolar and lung liquid clearance in anesthetized rabbits. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA Resolution of pulmonary edema. New insights. Matthay MA Right-heart catheterization is a diagnostic procedure not a therapeutic intervention. Chatterjee K, Matthay M Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Matthay MA, Wiener-Kronish JP Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Wiedemann HP, Matthay MA, Gillis CN The adult respiratory distress syndrome. Definition and prognosis. Matthay MA Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Wiener-Kronish JP, Gropper MA, Matthay MA Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". Heffner JE, Matthay MA Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Segredo V, Matthay MA, Sharma ML, Gruenke LD, Caldwell JE, Miller RD Pulmonary manifestations of endocrine and metabolic disorders. Brüssel T, Matthay MA, Chernow B Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA New modes of mechanical ventilation for ARDS. How should they be evaluated? Matthay MA Ureteral obstruction caused by vasculitis. Baskin L, Mee S, Matthay M, Carroll PR Respiratory management after cardiac surgery. Matthay MA, Wiener-Kronish JP The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. Matthay MA Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay MA, Crystal RG Bedside catheterization of the pulmonary artery: risks compared with benefits. Matthay MA, Chatterjee K Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC An expanded definition of the adult respiratory distress syndrome. Murray JF, Matthay MA, Luce JM, Flick MR Alveolar liquid and protein clearance from normal dog lungs. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. Ratnoff WD, Matthay MA, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Wiener-Kronish JP, Matthay MA Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Dean NC, Amend WC, Matthay MA Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. Berthiaume Y, Staub NC, Matthay MA The adult respiratory distress syndrome. Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS Central intravascular pressure measurements: when should we believe them? Gates LM, Matthay MA Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Fein A, Wiener-Kronish JP, Niederman M, Matthay MA Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K Clinical spectrum of pulmonary mucormycosis. Bigby TD, Serota ML, Tierney LM, Matthay MA Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass. Swerdlow BN, Mihm FG, Goetzl EJ, Matthay MA Pulmonary embolism. Guide to diagnosis, treatment, and prevention. Broaddus C, Matthay MA Intensive care unit: how stressful for physicians? Eisendrath SJ, Link N, Matthay M Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC Cellular basis for injury and repair in the adult respiratory distress syndrome. Matthay MA Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. Matthay MA, Berthiaume Y, Staub NC Pathophysiology of pulmonary edema. Matthay MA Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung. Matthay MA Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. Matthay MA, Eschenbacher WL, Goetzl EJ Neurogenic pulmonary edema. Colice GL, Matthay MA, Bass E, Matthay RA Morphologic and physiologic correlates of increased extravascular lung water. Bongard FS, Matthay M, Mackersie RC, Lewis FR Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Wiedemann HP, Matthay MA, Matthay RA Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Wiedemann HP, Matthay MA, Matthay RA Guillain-Barré syndrome: psychosocial aspects of management. Eisendrath SJ, Matthay MA, Dunkel JA, Zimmerman JK, Layzer RB Hemodynamic management in the adult respiratory distress syndrome. Prewitt RM, Matthay MA, Ghignone M Invasive hemodynamic monitoring in critically ill patients. Matthay MA Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC Differential liquid and protein clearance from the alveoli of anesthetized sheep. Matthay MA, Landolt CC, Staub NC Adult respiratory distress syndrome complicating diabetic ketoacidosis. Russell J, Follansbee S, Matthay M Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep. Landolt CC, Matthay MA, Staub NC Chest mass with pleurisy. Matthay MA, Addison TE, Ellinger G, Choy SH, Kaltreider HB Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV Acute pseudogout in the absence of synovial fluid Leukocytes. Matthay M, Lindamood M, Steigerwald JC, Solomons C Hypertrophic osteoarthropathy in adults with cystic fibrosis. Matthay MA, Matthay RA, Mills DM, Lakshminarayan S, Cotton E Grand mal seizure induced by oral theophylline. Matthay RA, Matthay MA, Weinberger MM
