Biography Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine. Role Faculty Category Clinical Specialties Critical Care Medicine Education Fellowship, 1979 - Cardiovascular Research Institute, University of California, San FranciscoFellowship, 1978 - Pulmonary DIvision, University of California, San FranciscoInternship and Residency, 1976 - Internal Medicine, University of Colorado Medical CenterM.D., 1973 - School of Medicine, University of PennsylvaniaA.B., 1969 - English, Harvard University Publications The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Zapatero-Belinchón FJ, McCavittMalvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Richards AL, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS . bioRxiv : the preprint server for biology . Aug 29, 2024 Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify key pathways associated with mortality. Alipanah-Lechner N, Neyton L, Sinha P, Leroux C, Bardillon K, Carrillo SA, Chak S, Chao O, Hariharan T, Henrickson C, Kangelaris K, Langelier CR, Lee D, Lin C, Liu K, Magee L, Ringor A, Sarma A, Schmiege E, Spottiswoode N, Sullivan K, Weingart MF, Willmore A, Zhuo H, Rogers AJ, Stringer KA, Matthay MA, Calfee CS . medRxiv : the preprint server for health sciences . Sep 10, 2025 Reply to "Comment on 'A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors'". Ware LB, Koyama T, Shaver CM, Matthay MA . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Sep 5, 2025 Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models. Molina C, Tsukui T, Khan IS, Ren X, Qiu W, Matthay M, Wolters P, Sheppard D . The Journal of clinical investigation . Aug 28, 2025 Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis. Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Tamaki SJ, Bivona TG, Abate AR, Wagner A, Pillai SK, Wolters PJ, Tharp KM, Bhattacharya M . The Journal of clinical investigation . Aug 28, 2025 Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025. Singh N, Koçana C, Schmidt EP, Hepokoski ML, Matthay MA, Stevens T . American journal of physiology. Lung cellular and molecular physiology . Aug 21, 2025 Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study. Sanchez PA, Obeidalla S, Kerchberger VE, Moore AR, Maddali MV, Kangelaris KN, Hendrickson CM, Evrard B, Liu KD, Bastarache JA, Matthay MA, Rogers AJ, Calfee CS . Critical care (London, England) . Aug 19, 2025 Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis. Spottiswoode N, Neyton LP, Mick E, Kalantar KL, Hao S, Lydon EC, Narendra R, Serpa PH, Caldera S, Gomez A, Hendrickson C, Kangelaris K, Liu KD, Sinha P, DeRisi JL, Matthay MA, Calfee CS, Langelier CR . American journal of respiratory and critical care medicine . Aug 11, 2025 Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial. Zinter MS, Taylor CS, Markovic D, Pellegrini M, Wong K, Balliu B, Gala KP, Asaro LA, Nadkarni VM, McQuillen PS, Vangala SS, Sinha P, Matthay MA, Agus MSD, Sapru A . American journal of respiratory and critical care medicine . Aug 1, 2025 Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT). Matthay MA, Zhou H, Sarma A, Alipanah-Lechner N, Hendrickson C, Kornblith LZ, Schreiber M, Zonies D, Khan A, Robinson B, Johnson NJ, Ware LB, Guillamondegui O, Casey J, Moore L, Patel B, Kao L, Wade CE, Fox E, Cox C, Khawanja F, Aguillon Prada R, Hossri S, Callcut R, Albertson T, Delucchi KL, McMillan M, Langelier CR, Pati S, McKenna DH, Leroux C, Calfee CS, Liu KD . American journal of respiratory and critical care medicine . Jul 29, 2025 Approaches for establishing trust and alleviating stress during the surrogate informed consent process for critical care research. Tietbohl CK, Glaros C, Torres KA, Avallone Mantelli R, Files DC, Mart MF, Matthay MA, Burns KEA, Matlock DD, Wynia M, Moss M . Chest . Jul 23, 2025 Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading. Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M . bioRxiv : the preprint server for biology . Jul 31, 2024 The lectin-like domain of TNF reduces pneumonia-induced injury in the perfused human lung. Maishan M, Taenaka H, Evrard B, Matsumoto S, Ringor A, Leroux C, Lucas R, Matthay MA . JCI Insight . Jun 9, 2025 The Performance of the Surrogate Informed Consent Process for Critical Care Research: A Multi-Modal Study of Investigators, Coordinators, Surrogates, and Patients. Glaros C, Tietbohl CK, Torres KA, Avallone Mantelli R, Files DC, Mart MF, Matthay MA, Burns KEA, Matlock DD, Wynia M, Moss M . Chest . Jun 6, 2025 Clonal Expansion of Alveolar Fibroblast Progeny Drives Pulmonary Fibrosis. Molina C, Tsukui T, Khan I, Ren X, Qiu W, Matthay M, Wolters P, Sheppard D . bioRxiv : the preprint server for biology . Jun 3, 2025 Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure. Lim MJ, Whitney JE, Sallee CJ, Markovic D, Bera A, Sinha P, Zeigler A, Chen L, Zinter MS, Ali A, Matthay MA, Schwingshackl A, Agus MSD, Sapru A, Pediatric Acute Lung Injury (PALI) and Coagulation and Fibrinolysis in Pediatric Insulin Titration T . Critical Care Medicine . Jun 3, 2025 Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome. Zalucky AA, Dianti J, Neyton LPA, Sinha P, Liu KD, Matthay MA, Thompson BT, Goligher EC, Calfee CS . American journal of respiratory and critical care medicine . Feb 25, 2025 Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality. Narendra R, Lydon EC, Van Phan H, Spottiswoode N, Neyton LP, Diray-Arce J, IMPACC Network, COMET Consortium, EARLI Consortium, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, Altman MC, Augustine AD, Bosinger S, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Carillo SA, Erle D, Hendrickson CM, Krummel MF, Matthay MA, Woodruff P, Haddad EK, Calfee CS, Langelier CR . medRxiv : the preprint server for health sciences . May 19, 2025 Awake Prone Positioning in COVID-19-Is There a New Standard of Care? Matthay MA, Wick KD, Alipanah-Lechner N . JAMA internal medicine . May 1, 2025 Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia. Neyton LPA, Matthay MA, Dela Cruz CS, Rizzo AN . The European respiratory journal . Apr 24, 2025 A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors. Ware LB, Koyama T, Shaver CM, Swain S, Nguyen J, Salehi A, Dhillon G, Wickersham N, Maheshwari J, Singer JP, Weigt SS, Kukreja J, Matthay MA . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Apr 3, 2025 Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury. Romero MJ, Yue Q, Ahn WM, Hamacher J, Zaidi Y, Haigh S, Sridhar S, Gonzales J, Hudel M, Huo Y, Verin AD, Pace BS, Stansfield BK, Maishan M, Neptune ER, Enkhbaatar P, Su Y, Chakraborty T, Gonsalvez G, Hummler E, Davis WB, Bogdanov VY, Fulton DJR, Csanyi G, Matthay MA, Eaton DC, Lucas R . American journal of respiratory cell and molecular biology . Oct 15, 2024 Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury. Upadhyay V, Ortega EF, Ramirez Hernandez LA, Alexander M, Kaur G, Trepka K, Rock RR, Shima RT, Cheshire WC, Alipanah-Lechner N, Calfee CS, Matthay MA, Lee JV, Goga A, Jain IH, Turnbaugh PJ . bioRxiv : the preprint server for biology . Mar 25, 2025 Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit. Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS . Annals of the American Thoracic Society . Oct 29, 2024 Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness. van Amstel RBE, Bartek B, Vlaar APJ, Gay E, van Vught LA, Cremer OL, Van der Poll T, Shapiro NI, Matthay MA, Calfee CS, Sinha P, Bos LDJ . American journal of respiratory and critical care medicine . Dec 6, 2024 Unlocking the Therapeutic Code of Mesenchymal Stromal Cells. Lingappan K, Matthay MA . American journal of respiratory and critical care medicine . Jan 23, 2025 Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs. Rolandsson Enes S, Dzneladze I, Hampton TH, Neff SL, Asarian L, Barua J, Tertel T, Giebel B, Pereyra N, McKenna DH, Hu P, Acton E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Dos Santos CC, Weiss DJ . Cytotherapy . Jan 20, 2025 Anti-CD14 treatment in patients with severe COVID-19: Clinical and biological effects in a Phase 2 randomized open-label adaptive platform clinical trial. Mabrey FL, Martin TR, Calfee CS, Liu KD, LaCombe B, Brown-Swigart L, Discacciati A, Eklund M, Heckbert SR, Matthay MA, Esserman L, Wurfel MM . CHEST critical care . Dec 9, 2024 Pneumothoraces Associated With Vaping Cannabis Concentrate. Olgin GK, Ludwig C, Matthay MA, Gribben V . Pediatrics . Nov 1, 2024 Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell-based therapeutics. Renesme L, Cobey KD, Lalu MM, Bubela T, Chinnadurai R, De Vos J, Dunbar R, Fergusson D, Freund D, Galipeau J, Horwitz E, Lê M, Matthay M, Moher D, Nolta J, Parker G, Phinney DG, Rao M, Rasko JEJ, Rocco PRM, Rossi F, Myles MR, Viswanathan S, Thébaud B . Cytotherapy . Oct 29, 2024 Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR . Nature communications . Oct 29, 2024 Acute respiratory distress syndrome. Wick KD, Ware LB, Matthay MA . BMJ (Clinical research ed.) . Oct 28, 2024 Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects. Zalucky AA, Matthay MA, Ware LB . Clinics in chest medicine . Sep 20, 2024 Definitions of Acute Respiratory Distress Syndrome: Present Recommendations and Challenges. Jayasimhan D, Matthay MA . Clinics in chest medicine . Sep 5, 2024 Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial. Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinic . JAMA . May 19, 2024 Immediate myeloid depot for SARS-CoV-2 in the human lung. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR . Science advances . Jul 31, 2024 Longitudinal Importance of the Soluble Receptor for Advanced Glycation End-Products in Non-intubated Hospitalized Patients with COVID-19 Pneumonia. Wick KD, Siegel L, Oldmixon C, Lundgren JD, Thompson BT, Jones C, Leroux C, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 30, 2024 Use of modified Berlin criteria in identifying patients with acute respiratory distress syndrome: a single-centre retrospective cohort study. Thompson JH, Reddy K, Matthay MA, McAuley DF, Simpson AJ, Rostron AJ . British journal of anaesthesia . Jul 16, 2024 Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation. Koyama T, Zhao Z, Balmes JR, Calfee CS, Matthay MA, Reilly JP, Porteous MK, Diamond JM, Christie JD, Cantu E, Ware LB, Lung Transplant Outcomes Group . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Jul 15, 2024 A fibroblast-dependent TGFß1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis. Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Jourdan Le Saux C . The Journal of clinical investigation . Jul 9, 2024 11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis. Mahida RY, Yuan Z, Kolluri KK, Scott A, Parekh D, Hardy RS, Matthay MA, Perkins GD, Janes SM, Thickett DR . Frontiers in bioengineering and biotechnology . Jul 5, 2024 NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M . Scientific reports . Jul 4, 2024 Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection. Zhao C, Pan M, Chen J, Li L, Zhang Y, Liu W, Matthay MA, Wang H, Jin X, Xu JF, Su X . Journal of medical virology . Jul 1, 2024 Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials. Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M . Intensive care medicine . Jun 12, 2024 Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA . Critical care (London, England) . May 29, 2024 Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study. Jensen TO, Murray TA, Grandits GA, Jain MK, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure S, Leshnower BG, Looney D, Moschopoulos CD, Mugerwa H, Murray DD, Mylonakis E, Nagy-Agren S, Rehman MT, Rupert A, Stevens R, Turville S, Weintrob A, Wick K, Lundgren J, Ko ER, ACTIV-3/TICO Study Group . The Lancet. Microbe . May 27, 2024 Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice. Taenaka H, Fang X, Maishan M, Trivedi A, Wick KD, Gotts JE, Martin TR, Calfee CS, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 21, 2024 Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies. Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB . CHEST critical care . May 15, 2024 Reply to Du, et al. and Palanidurai, et al. Matthay MA, Ware LB, Riviello ED, Wick KD, Thompson T, Martin TR . American journal of respiratory and critical care medicine . Mar 20, 2024 Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS . Critical care (London, England) . May 14, 2024 Life-saving effect of pulmonary surfactant in premature babies. Raj JU, Bland RD, Bhattacharya J, Rabinovitch M, Matthay MA . The Journal of clinical investigation . May 1, 2024 Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome. Baedorf-Kassis E, Murn M, Dzierba AL, Serra AL, Garcia I, Minus E, Padilla C, Sarge T, Goodspeed VM, Matthay MA, Gong MN, Cook D, Loring SH, Talmor D, Beitler JR, EPVent-2 Study Group . Critical care (London, England) . Apr 23, 2024 Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS . Critical care (London, England) . Apr 22, 2024 The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia. Chouchane O, Schuurman AR, Reijnders TDY, Peters-Sengers H, Butler JM, Uhel F, Schultz MJ, Bonten MJ, Cremer OL, Calfee CS, Matthay MA, Langley RJ, Alipanah-Lechner N, Kingsmore SF, Rogers A, Weeghel MV, Vaz FM, van der Poll T . American journal of respiratory and critical care medicine . Jan 19, 2024 Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock. Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN . Journal of the American College of Emergency Physicians open . Apr 9, 2024 Cell-based Therapies for ARDS - Where Are We Now? Curley GF, O'Kane CM, McAuley DF, Matthay MA, Laffey JG . American journal of respiratory and critical care medicine . Feb 7, 2024 Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS . American journal of respiratory and critical care medicine . Jan 8, 2024 Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time. Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS, NHLBI PETAL Network . American journal of respiratory and critical care medicine . Feb 12, 2024 Inter- and Intra-donor variability in bone marrow-derived mesenchymal stromal cells: implications for clinical applications. Trivedi A, Lin M, Miyazawa B, Nair A, Vivona L, Fang X, Bieback K, Schäfer R, Spohn G, McKenna D, Zhuo H, Matthay MA, Pati S . Cytotherapy . Mar 30, 2024 Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19. Jensen TO, Grandits GA, Jain MK, Murray TA, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure S, Leshnower BG, Looney D, Moschopoulos CD, Mugerwa H, Murray DD, Mylonakis E, Nagy-Agren S, Rehman MT, Rupert A, Stevens RA, Turville S, Weintrob A, Wick K, Lundgren J, Ko ER, ACTIV-3/TICO Study Group . The Journal of infectious diseases . Nov 9, 2023 The Translational Value of Rodent Models of Sepsis. Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR . American journal of respiratory and critical care medicine . Dec 13, 2023 Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA . Research square . Feb 21, 2024 Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial. Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium . Critical care (London, England) . Feb 21, 2024 Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS). Mehta P, Samanta RJ, Wick K, Coll RC, Mawhinney T, McAleavey PG, Boyle AJ, Conlon J, Shankar-Hari M, Rogers A, Calfee CS, Matthay MA, Summers C, Chambers RC, McAuley DF, O'Kane CM . Thorax . Dec 26, 2023 The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients. Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR . Nature communications . Jan 2, 2024 A New Global Definition of Acute Respiratory Distress Syndrome. Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri VM, Riviello ED, Rubin E, Slutsky AS, Thompson BT, Twagirumugabe T, Ware LB, Wick KD . American journal of respiratory and critical care medicine . Jan 1, 2024 Unraveling the enigma of genetics and phenotypes in ARDS. Artigas A, Barbas CSV, Matthay MA . Intensive care medicine . Dec 12, 2023 In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH . Science advances . Dec 8, 2023 Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia. Jayasimhan D, Matthay MA . BJA education . Oct 19, 2023 Evidence for lung barrier regeneration by differentiation prior to binucleated and stem cell division. Guild J, Juul NH, Andalon A, Taenaka H, Coffey RJ, Matthay MA, Desai TJ . The Journal of cell biology . Oct 16, 2023 MicroRNA-1 protects the endothelium in acute lung injury. Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay MA, Pober JS, Pierce RW, Takyar SS . JCI Insight . Sep 22, 2023 The antibiotic resistance reservoir of the lung microbiome expands with age. Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR . Research square . Sep 18, 2023 Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials. Moore AR, Pienkos SM, Sinha P, Guan J, O'Kane CM, Levitt JE, Wilson JG, Shankar-Hari M, Matthay MA, Calfee CS, Baron RM, McAuley DF, Rogers AJ . Critical Care Medicine . Sep 11, 2023 Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS . The Lancet. Respiratory medicine . Aug 23, 2023 Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB . Intensive care medicine . Jul 20, 2023 Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series. Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S . Frontiers in medicine . Jul 6, 2023 Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. 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Nov 1, 2021 Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome. Lim MJ, Zinter MS, Chen L, Wong KMY, Bhalla A, Gala K, Guglielmo M, Alkhouli M, Huard LL, Hanudel MR, Vangala S, Schwingshackl A, Matthay M, Sapru A . Critical Care Medicine . Oct 25, 2021 Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells. Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ . The European respiratory journal . Oct 14, 2021 Environmental Factors. Wick KD, Matthay MA . Critical care clinics . Oct 1, 2021 Preface. Matthay MA, Liu KD . Critical care clinics . Oct 1, 2021 Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome. Mahida RY, Scott A, Parekh D, Lugg ST, Belchamber KBR, Hardy RS, Matthay MA, Naidu B, Thickett DR . Frontiers in medicine . Sep 29, 2021 Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs. Zhang X, Sugita S, Liu A, Naito Y, Hwang W, Qiu H, Sakamoto A, Sawa T, Matthay MA, Lee JW . American journal of physiology. Lung cellular and molecular physiology . Sep 15, 2021 Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis. Mahida RY, Scott A, Parekh D, Lugg ST, Hardy RS, Lavery GG, Matthay MA, Naidu B, Perkins GD, Thickett DR . The European respiratory journal . Sep 9, 2021 Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. 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The New England journal of medicine . Aug 4, 2021 Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Monteiro ACC, Flori H, Dahmer MK, Sim MS, Quasney MW, Curley MAQ, Matthay MA, Sapru A, BALI Study Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Networ . Critical care (London, England) . Aug 3, 2021 Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. 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Dec 1, 2020 Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE . American journal of respiratory cell and molecular biology . Dec 1, 2020 Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. 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JAMA . Dec 1, 2020 Alternative Tobacco Product Use in Critically Ill Patients. Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS . International journal of environmental research and public health . Nov 24, 2020 Phenotypes and personalized medicine in the acute respiratory distress syndrome. Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS . Intensive care medicine . Nov 18, 2020 Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies. Ware LB, Matthay MA, Mebazaa A . Intensive care medicine . Nov 2, 2020 Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties. Matthay MA, Thompson BT . The Lancet. Respiratory medicine . Oct 29, 2020 Global Absence and Targeting of Protective Immune States in Severe COVID-19. 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Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD . American journal of physiology. Renal physiology . Oct 12, 2020 Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation. Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA . PloS one . Oct 6, 2020 The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung. Leligdowicz A, Ross JT, Nesseler N, Matthay MA . Intensive care medicine experimental . Sep 21, 2020 Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N . American journal of respiratory and critical care medicine . Sep 15, 2020 Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression. Ji HJ, Su Z, Zhao R, Komissarov AA, Yi G, Liu SL, Idell S, Matthay MA . medRxiv : the preprint server for health sciences . Sep 11, 2020 Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S . American journal of physiology. Lung cellular and molecular physiology . Sep 9, 2020 NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) . Transfusion . Sep 9, 2020 Is a "Cytokine Storm" Relevant to COVID-19? Sinha P, Matthay MA, Calfee CS . JAMA internal medicine . Sep 1, 2020 Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA . American journal of respiratory and critical care medicine . Aug 15, 2020 Need for Additional Trials of Vitamin C for Sepsis. Files DC, Liu KD, Matthay M . JAMA . Aug 11, 2020 Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure. Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR . Pediatric pulmonology . Aug 7, 2020 Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep. Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF . American journal of respiratory and critical care medicine . Aug 1, 2020 Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD . Critical care (London, England) . Jul 11, 2020 Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome. Mahida RY, Matsumoto S, Matthay MA . American journal of respiratory cell and molecular biology . Jul 1, 2020 The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jun 10, 2020 Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS . Critical Care Medicine . Jun 1, 2020 Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect. Kohne JG, Dahmer MK, Weeks HM, Kaciroti N, Quasney MW, Sapru A, Curley MAQ, Matthay M, Flori H . Critical Care Medicine . Jun 1, 2020 Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels. Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL . British journal of pharmacology . May 11, 2020 Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life. Block BL, Jeon SY, Sudore RL, Matthay MA, Boscardin WJ, Smith AK . JAMA internal medicine . May 1, 2020 The potential of lipid mediator networks as ocular surface therapeutics and biomarkers. Flitter BA, Fang X, Matthay MA, Gronert K . The ocular surface . Apr 29, 2020 Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D . Nature communications . Apr 21, 2020 Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. Dahmer MK, Flori H, Sapru A, Kohne J, Weeks HM, Curley MAQ, Matthay MA, Quasney MW, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS . Chest . Apr 8, 2020 Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M, ESICM Translational Biology Group of the Acute Respiratory Failure section . Respiratory research . Apr 7, 2020 Gender Differences in Authorship of Critical Care Literature. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ . American journal of respiratory and critical care medicine . Apr 1, 2020 Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Ji HL, Zhao R, Matalon S, Matthay MA . Physiological reviews . Mar 27, 2020 Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS . Intensive care medicine . Mar 23, 2020 Treatment for severe acute respiratory distress syndrome from COVID-19. Matthay MA, Aldrich JM, Gotts JE . The Lancet. Respiratory medicine . Mar 20, 2020 Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study. Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J . The Journal of thoracic and cardiovascular surgery . Mar 4, 2020 Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults. Hendrickson CM, Matthay MA . Critical Care Medicine . Mar 1, 2020 Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Harhay MO, Casey JD, Clement M, Collins SP, Gayat É, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A . Intensive care medicine . Feb 18, 2020 Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN . Critical Care Medicine . Feb 1, 2020 Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ . The European respiratory journal . Jan 16, 2020 Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials. Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS . The Lancet. Respiratory medicine . Jan 13, 2020 Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome. Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ . American journal of respiratory and critical care medicine . Jan 1, 2020 The authors reply. Rogers AJ, Desai M, Matthay MA, Choi AM, Baron RM . Critical Care Medicine . Jan 1, 2020 Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD . Critical care (London, England) . Dec 9, 2019 The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD . PloS one . Nov 26, 2019 Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs. Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW . American journal of respiratory and critical care medicine . Nov 15, 2019 Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene. Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie HG, Chang Y, Zhang M, Liu Y, Jain K, Jung BG, Samten B, Jiang D, Liang J, Ikebe M, Matthay MA, Ji HL . Theranostics . Oct 18, 2019 Lung inflammatory environments differentially alter mesenchymal stromal cell behavior. Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ . American journal of physiology. Lung cellular and molecular physiology . Sep 25, 2019 Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Sep 11, 2019 Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome. Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A . PloS one . Sep 5, 2019 A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs. White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL . Critical Care Medicine . Sep 1, 2019 Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome. Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM . Critical Care Medicine . Aug 1, 2019 The Continued Need for Clinical Trials in Deceased Organ Donor Management. Niemann CU, Matthay MA, Ware LB . Transplantation . Jul 1, 2019 The ex vivo human lung: research value for translational science. Ross JT, Nesseler N, Lee JW, Ware LB, Matthay MA . JCI Insight . Jun 6, 2019 Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA . Respiratory care . May 28, 2019 Pathogenesis of Acute Respiratory Distress Syndrome. Huppert LA, Matthay MA, Ware LB . Seminars in respiratory and critical care medicine . May 6, 2019 Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units. Scheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB . JAMA internal medicine . May 1, 2019 Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome? Lee JW, Matthay MA . Anesthesiology . May 1, 2019 A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome. Flori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK, BALI and RESTORE Study Investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) . Critical care (London, England) . Apr 17, 2019 Could Decisions to Limit Treatment Contribute to Mortality Differences between Patients with Different Presepsis Trajectories? Block BL, Matthay M . Annals of the American Thoracic Society . Apr 1, 2019 Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM . American journal of respiratory and critical care medicine . Apr 1, 2019 Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Apr 1, 2019 Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS . The Lancet. Respiratory medicine . Apr 1, 2019 The authors reply. Fielding-Singh V, Matthay MA, Calfee CS . Critical Care Medicine . Apr 1, 2019 The authors reply. Fielding-Singh V, Matthay MA, Calfee CS . Critical Care Medicine . Apr 1, 2019 Acute respiratory distress syndrome. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS . Nature reviews. Disease primers . Mar 14, 2019 Heterogeneity in sepsis: new biological evidence with clinical applications. Leligdowicz A, Matthay MA . Critical care (London, England) . Mar 9, 2019 AIMing Immunomodulation Therapy at Sepsis. Leligdowicz A, Matthay MA . American journal of respiratory cell and molecular biology . Mar 1, 2019 Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M, The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (P . Annals of the American Thoracic Society . Mar 1, 2019 Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH . American journal of respiratory and critical care medicine . Feb 1, 2019 Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A . American journal of respiratory and critical care medicine . Jan 15, 2019 ECMO in severe acute respiratory distress syndrome. Matthay MA . The Lancet. Respiratory medicine . Jan 11, 2019 Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB . American journal of respiratory and critical care medicine . Jan 1, 2019 Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome. Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Dec 1, 2018 Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL . Proceedings of the National Academy of Sciences of the United States of America . Nov 27, 2018 Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD . The Lancet. Respiratory medicine . Nov 16, 2018 Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Fielding-Singh V, Matthay MA, Calfee CS . Critical Care Medicine . Nov 1, 2018 Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. Huppert LA, Liu KD, Matthay MA . Transfusion . Nov 1, 2018 Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ . Intensive care medicine . Oct 21, 2018 Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS, NHLBI ARDS Network . Intensive care medicine . Oct 5, 2018 Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Oct 1, 2018 Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. Mi MY, Matthay MA, Morris AH . The New England journal of medicine . Aug 30, 2018 Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J . Tobacco control . Aug 29, 2018 Possible hepatotoxicity of IQOS. Chun L, Moazed F, Matthay M, Calfee C, Gotts J . Tobacco control . Aug 21, 2018 Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury. Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL . Frontiers in immunology . Aug 20, 2018 Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia. Park J, Kim S, Lim H, Liu A, Hu S, Lee J, Zhuo H, Hao Q, Matthay MA, Lee JW . Thorax . Aug 3, 2018 Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF, Irish Critical Care Trials Group . The Lancet. Respiratory medicine . Aug 2, 2018 Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD . Canadian journal of kidney health and disease . Aug 2, 2018 Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ. Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA . Physiological reports . Aug 1, 2018 Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome. Kallet RH, Ho K, Lipnick MS, Matthay MA . Journal of thoracic disease . Aug 1, 2018 Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS . Intensive care medicine . Jul 26, 2018 Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 19, 2018 Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T . The Journal of clinical investigation . Jul 12, 2018 Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials. Pais FM, Sinha P, Liu KD, Matthay MA . Respiratory care . Jul 10, 2018 A psychometric study of the decisional conflict scale in surrogate decision makers. Pecanac KE, Brown RL, Steingrub J, Anderson W, Matthay MA, White DB . Patient education and counseling . Jul 7, 2018 Secondary peritonitis: principles of diagnosis and intervention. Ross JT, Matthay MA, Harris HW . BMJ (Clinical research ed.) . Jun 18, 2018 Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB . Thorax . Jun 14, 2018 Mesenchymal stromal cells and macrophages in sepsis: new insights. Kotas ME, Matthay MA . The European respiratory journal . Apr 26, 2018 Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study- . Critical Care Medicine . Apr 1, 2018 Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Hendrickson CM, Matthay MA . Pulmonary circulation . Mar 26, 2018 Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Mar 15, 2018 Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK . American journal of physiology. Lung cellular and molecular physiology . Mar 8, 2018 Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution. Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD . American journal of medical quality : the official journal of the American College of Medical Quality . Feb 23, 2018 Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J . Clinical transplantation . Feb 23, 2018 The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH . Stem cells (Dayton, Ohio) . Feb 14, 2018 Cell-based Therapy in Sepsis. A Step Closer. Gotts JE, Matthay MA . American journal of respiratory and critical care medicine . Feb 1, 2018 Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S . The journal of trauma and acute care surgery . Feb 1, 2018 Exosome-based Therapy for Bronchopulmonary Dysplasia. Matthay MA, Abman SH . American journal of respiratory and critical care medicine . Jan 1, 2018 Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions. Fang X, Matthay MA . Methods in molecular biology (Clifton, N.J.) . Jan 1, 2018 Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA . American journal of critical care : an official publication, American Association of Critical-Care Nurses . Jan 1, 2018 Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania. Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T . Frontiers in pediatrics . Dec 22, 2017 The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C . American journal of respiratory cell and molecular biology . Dec 1, 2017 ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration. Ding Y, Zhao R, Zhao X, Matthay MA, Nie HG, Ji HL . Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology . Nov 27, 2017 Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications. Matthay MA . American journal of respiratory and critical care medicine . Nov 15, 2017 Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Nov 8, 2017 Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, PALISI PICFlu Investigators, Hertz T, Randolph AG . Frontiers in immunology . Nov 6, 2017 Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE . American journal of physiology. Lung cellular and molecular physiology . Nov 1, 2017 Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA . Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco . Sep 1, 2017 Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries. Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS . Trauma surgery & acute care open . Aug 28, 2017 Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Laffey JG, Matthay MA . American journal of respiratory and critical care medicine . Aug 1, 2017 Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE . Nature cell biology . Jul 24, 2017 Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction. Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R . Frontiers in immunology . Jul 21, 2017 Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA . Critical Care Medicine . Jul 1, 2017 Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Crouser ED, Matthay MA . Chest . Jul 1, 2017 Inhalation therapies in acute respiratory distress syndrome. Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA . Annals of translational medicine . Jul 1, 2017 Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS. Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay MA . Respiratory care . Jun 13, 2017 External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB . Intensive care medicine . Jun 7, 2017 Clinical trials in acute respiratory distress syndrome: challenges and opportunities. Matthay MA, McAuley DF, Ware LB . The Lancet. Respiratory medicine . May 26, 2017 Pulmonary toxicity of e-cigarettes. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE . American journal of physiology. Lung cellular and molecular physiology . May 18, 2017 Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial. McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM . The Lancet. Respiratory medicine . May 16, 2017 Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF . Trials . May 11, 2017 Understanding blood gas analysis. Gattinoni L, Pesenti A, Matthay M . Intensive care medicine . May 11, 2017 Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group . Transfusion . May 3, 2017 Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A . Critical Care Medicine . May 1, 2017 Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE . Critical Care Medicine . May 1, 2017 Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC . PloS one . Apr 18, 2017 Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA, Su X . Cell discovery . Apr 11, 2017 Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Huppert LA, Matthay MA . Frontiers in immunology . Apr 7, 2017 Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset. Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Mar 3, 2017 Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, NHLBI ARDS Network . American journal of physiology. Lung cellular and molecular physiology . Feb 17, 2017 Protein biomarkers associated with primary graft dysfunction following lung transplantation. Hamilton BC, Kukreja J, Ware LB, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jan 27, 2017 Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Matthay MA, Pati S, Lee JW . Stem cells (Dayton, Ohio) . Jan 19, 2017 Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) . Vox sanguinis . Dec 21, 2016 Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM . Critical care (London, England) . Nov 17, 2016 Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Matthay MA, Beitler JR . Chest . Nov 1, 2016 Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? Moore PK, Matthay MA . JAMA internal medicine . Nov 1, 2016 What drives neutrophils to the alveoli in ARDS? Zemans RL, Matthay MA . Thorax . Oct 18, 2016 Cathepsin L Helps to Defend Mice from Infection with Influenza A. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH . PloS one . Oct 7, 2016 Challenges in predicting which patients will develop ARDS. Matthay MA . The Lancet. Respiratory medicine . Oct 4, 2016 A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Oct 1, 2016 Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Oct 1, 2016 IL1RL1 asthma risk variants regulate airway type 2 inflammation. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA . JCI Insight . Sep 8, 2016 Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network . Critical Care Medicine . Sep 1, 2016 The authors reply. Kangelaris KN, Ware LB, Matthay MA, Calfee CS . Critical Care Medicine . Aug 1, 2016 The authors reply. Kangelaris KN, Ware LB, Matthay MA, Calfee CS . Critical Care Medicine . Aug 1, 2016 miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ . PloS one . Jun 30, 2016 Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D . Intensive care medicine . Jun 24, 2016 A new experimental model of acid- and endotoxin-induced acute lung injury in rats. Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A . American journal of physiology. Lung cellular and molecular physiology . Jun 17, 2016 The acute respiratory distress syndrome following isolated severe traumatic brain injury. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ . The journal of trauma and acute care surgery . Jun 1, 2016 Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network . Critical care (London, England) . May 23, 2016 Sepsis: pathophysiology and clinical management. Gotts JE, Matthay MA . BMJ (Clinical research ed.) . May 23, 2016 Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS . American journal of respiratory and critical care medicine . May 15, 2016 Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD . Stem cells (Dayton, Ohio) . Apr 29, 2016 Negative-Pressure Pulmonary Edema. Bhattacharya M, Kallet RH, Ware LB, Matthay MA . Chest . Apr 8, 2016 Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ . Intensive care medicine . Apr 1, 2016 Diagnostic workup for ARDS patients. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU . Intensive care medicine . Mar 23, 2016 Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS . Proceedings of the National Academy of Sciences of the United States of America . Mar 14, 2016 Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs. Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay MA, Anderson WG, Peterson MW, Steingrub JS, Arnold RM, White DB . Journal of critical care . Mar 8, 2016 Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema. Walter JM, Matthay MA, Gillespie CT, Corbridge T . Annals of the American Thoracic Society . Mar 1, 2016 New Strategies for Effective Therapeutics in Critically Ill Patients. Matthay MA, Liu KD . JAMA . Feb 23, 2016 Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS . Thorax . Feb 2, 2016 Acute cor pulmonale and the acute respiratory distress syndrome. Guérin C, Matthay MA . Intensive care medicine . Jan 13, 2016 Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS . Critical Care Medicine . Jan 1, 2016 Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A . Critical care (London, England) . Dec 14, 2015 Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A . American journal of physiology. Lung cellular and molecular physiology . Dec 11, 2015 Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB . Critical Care Medicine . Sep 1, 2015 Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW . American journal of respiratory and critical care medicine . Aug 1, 2015 Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Matthay MA, Ware LB . American journal of respiratory and critical care medicine . Jul 15, 2015 Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . Jun 26, 2015 Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP . American journal of physiology. Lung cellular and molecular physiology . Jun 12, 2015 Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB . Chest . Jun 1, 2015 Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D . Journal of immunology (Baltimore, Md. : 1950) . May 22, 2015 Saving lives with high-flow nasal oxygen. Matthay MA . The New England journal of medicine . May 17, 2015 Sedation protocol for critically ill pediatric patients--reply. Curley MA, Wypij D, Matthay MA, RESTORE Study Investigators . JAMA . May 5, 2015 Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A . Critical Care Medicine . May 1, 2015 Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation. Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Lee JW . American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Apr 6, 2015 Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Wilson J, McKenna D, Liu KD, Matthay MA . The Lancet. Respiratory medicine . Apr 1, 2015 Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS . American journal of physiology. Lung cellular and molecular physiology . Mar 20, 2015 Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network . Intensive care medicine . Mar 1, 2015 Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Matthay MA . Annals of the American Thoracic Society . Mar 1, 2015 Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group . Transfusion . Feb 23, 2015 Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network . Intensive care medicine . Feb 3, 2015 A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units. Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB . Annals of the American Thoracic Society . Feb 1, 2015 Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA, RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network . JAMA . Jan 27, 2015 Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA . The Journal of biological chemistry . Jan 2, 2015 Body temperature and mortality in patients with acute respiratory distress syndrome. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network . American journal of critical care : an official publication, American Association of Critical-Care Nurses . Jan 1, 2015 Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA . Nature . Dec 24, 2014 Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA . The Lancet. Respiratory medicine . Dec 17, 2014 Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR . Transfusion . Dec 8, 2014 Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Hendrickson CM, Crestani B, Matthay MA . Intensive care medicine . Dec 6, 2014 Biomarkers to exclude the diagnosis of ventilator-associated pneumonia. Matthay MA . Thorax . Oct 28, 2014 Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Walter J, Ware LB, Matthay MA . The Lancet. Respiratory medicine . Oct 28, 2014 Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Gotts JE, Matthay MA . Clinics in chest medicine . Sep 24, 2014 Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR . Thorax . Sep 12, 2014 A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R . American journal of respiratory and critical care medicine . Sep 1, 2014 Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network . Critical Care Medicine . Sep 1, 2014 Is there a need for emerging drugs for the acute respiratory distress syndrome? Fitzgerald M, McAuley DF, Matthay M . Expert opinion on emerging drugs . Aug 24, 2014 Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS, California Transplant Donor Network . American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Aug 21, 2014 Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK . American journal of physiology. Lung cellular and molecular physiology . Aug 1, 2014 Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Gotts JE, Abbott J, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 18, 2014 Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction. Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R . Frontiers in physiology . Jul 15, 2014 Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA . Annals of intensive care . Jul 3, 2014 Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS . Journal of intensive care . Jul 1, 2014 Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group . Critical Care Medicine . Jul 1, 2014 Translational studies in the ex vivo human lung. Sakuma T, Matthay MA . Respiratory investigation . Jun 26, 2014 Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM . American journal of respiratory and critical care medicine . Jun 15, 2014 Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS . PloS one . Jun 10, 2014 Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P . Thorax . Jun 2, 2014 Resolution of pulmonary edema. Thirty years of progress. Matthay MA . American journal of respiratory and critical care medicine . Jun 1, 2014 Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation. McKenna D, Matthay MA, Pati S . Stem cells and development . May 27, 2014 Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, NHLBI ARDS Network . The Lancet. Respiratory medicine . May 19, 2014 Rosuvastatin for sepsis-associated acute respiratory distress syndrome. National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT . The New England journal of medicine . May 18, 2014 Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. Wilson JG, Matthay MA . Journal of hospital medicine . Apr 15, 2014 Applying metabolomics to uncover novel biology in ARDS. Rogers AJ, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 11, 2014 Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C . American journal of physiology. Lung cellular and molecular physiology . Mar 28, 2014 A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA, California Transplant Donor Network . American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Mar 1, 2014 Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB . Annals of intensive care . Feb 18, 2014 Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW . American journal of physiology. Lung cellular and molecular physiology . Feb 14, 2014 Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ . American journal of respiratory and critical care medicine . Feb 1, 2014 Metabolomic derangements are associated with mortality in critically ill adult patients. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM . PloS one . Jan 30, 2014 Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significanc Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M . The Journal of thoracic and cardiovascular surgery . Jan 22, 2014 One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN . Intensive care medicine . Jan 17, 2014 TGF-β and lung fluid balance in ARDS. Frank JA, Matthay MA . Proceedings of the National Academy of Sciences of the United States of America . Jan 13, 2014 Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM . Annals of surgery . Jan 1, 2014 Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW . Stem cells (Dayton, Ohio) . Jan 1, 2014 The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA, National Heart Lung and Blood Institute ARDS Network Investigators . Respiratory care . Dec 31, 2013 Treating ARDS: new hope for a tough problem. Gotts JE, Matthay MA . The Lancet. Respiratory medicine . Dec 23, 2013 Cystic fibrosis epithelial cell and bacterial binding. Engel J, Matthay M . American journal of physiology. Lung cellular and molecular physiology . Dec 1, 2013 Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL, National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome Network . Critical Care Medicine . Nov 1, 2013 Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA . Critical care (London, England) . Oct 24, 2013 Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF . Annals of intensive care . Aug 11, 2013 Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Hendrickson CM, Matthay MA . Seminars in respiratory and critical care medicine . Aug 11, 2013 Acute cor pulmonale in ARDS. Vieillard-Baron A, Price LC, Matthay MA . Intensive care medicine . Aug 2, 2013 Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ . American journal of respiratory and critical care medicine . Aug 1, 2013 Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA . Critical Care Medicine . Aug 1, 2013 Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Toonkel RL, Hare JM, Matthay MA, Glassberg MK . American journal of respiratory and critical care medicine . Jul 15, 2013 Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. Glassberg MK, Hare JM, Toonkel RL, Matthay MA . American journal of respiratory and critical care medicine . Jul 15, 2013 Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN . American journal of physiology. Lung cellular and molecular physiology . Jun 21, 2013 Cell therapy for lung disease: a step forward. Gotts JE, Matthay MA . Chest . Jun 1, 2013 The acute respiratory distress syndrome in 2013. Matthay MA, Song Y, Bai C, Jones KD . Translational respiratory medicine . May 17, 2013 HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1. Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J . PloS one . May 16, 2013 Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS . American journal of respiratory and critical care medicine . Apr 1, 2013 The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. Thompson BT, Matthay MA . American journal of respiratory and critical care medicine . Apr 1, 2013 The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A . The Journal of clinical investigation . Apr 1, 2013 Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA . American journal of respiratory and critical care medicine . Apr 1, 2013 Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ . Journal of immunology (Baltimore, Md. : 1950) . Mar 29, 2013 Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. Seeley EJ, Rosenberg P, Matthay MA . The Journal of clinical investigation . Feb 22, 2013 Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF . Trials . Feb 18, 2013 Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M . Molecular medicine (Cambridge, Mass.) . Feb 8, 2013 Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF . Shock (Augusta, Ga.) . Feb 1, 2013 Risk factors and outcomes in transfusion-associated circulatory overload. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group . The American journal of medicine . Jan 26, 2013 From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Schultz MJ, Juffermans NP, Matthay MA . Intensive care medicine . Jan 10, 2013 Cecal ligation model of sepsis in mice: new insights. Bastarache JA, Matthay MA . Critical Care Medicine . Jan 1, 2013 Hyperoxic acute lung injury. Kallet RH, Matthay MA . Respiratory care . Jan 1, 2013 Regulation and repair of the alveolar-capillary barrier in acute lung injury. Bhattacharya J, Matthay MA . Annual review of physiology . Jan 1, 2013 IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF . FASEB journal : official publication of the Federation of American Societies for Experimental Biology . Dec 6, 2012 Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK . American journal of physiology. Lung cellular and molecular physiology . Oct 12, 2012 Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG . American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Sep 20, 2012 Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD . American journal of physiology. Lung cellular and molecular physiology . Aug 3, 2012 The acute respiratory distress syndrome. Matthay MA, Ware LB, Zimmerman GA . The Journal of clinical investigation . Aug 1, 2012 The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Zeyed YF, Bastarache JA, Matthay MA, Ware LB . American journal of physiology. Lung cellular and molecular physiology . Jul 20, 2012 Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS . Journal of intensive care medicine . Jun 24, 2012 Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Levitt JE, Matthay MA . Critical care (London, England) . Jun 19, 2012 Inflection points in sepsis biology: from local defense to systemic organ injury. Seeley EJ, Matthay MA, Wolters PJ . American journal of physiology. Lung cellular and molecular physiology . Jun 15, 2012 Cell-based therapy for acute lung injury: are we there yet? Lee JW, Zhu Y, Matthay MA . Anesthesiology . Jun 1, 2012 Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA, NHLBI ARDS Network . Critical Care Medicine . Jun 1, 2012 The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA . American journal of physiology. Lung cellular and molecular physiology . Jun 1, 2012 Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T . American journal of respiratory cell and molecular biology . May 10, 2012 Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB . Stem cells translational medicine . May 8, 2012 IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D . American journal of physiology. Lung cellular and molecular physiology . May 4, 2012 Progress in modelling acute lung injury in a pre-clinical mouse model. Matthay MA, Howard JP . The European respiratory journal . May 1, 2012 Mesenchymal stem cells and the stem cell niche: a new chapter. Gotts JE, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 13, 2012 Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Mar 16, 2012 Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ . Histopathology . Mar 6, 2012 The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA, DOGMATIC Study Investigators . American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Mar 5, 2012 Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated? Kallet RH, Alonso JA, Matthay MA . Respiratory care . Mar 1, 2012 Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA, California Transplant Donor Network . Clinical transplantation . Feb 10, 2012 Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA . FASEB journal : official publication of the Federation of American Societies for Experimental Biology . Feb 7, 2012 Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H, Trauma ALI SNP Consortium (TASC) investigators . PloS one . Jan 25, 2012 Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV . Proceedings of the National Academy of Sciences of the United States of America . Jan 23, 2012 Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA . Thorax . Jan 16, 2012 Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR . American journal of physiology. Lung cellular and molecular physiology . Dec 29, 2011 The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network . Chest . Dec 29, 2011 A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators . Critical Care Medicine . Dec 1, 2011 Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD, National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress S . Critical Care Medicine . Dec 1, 2011 Transfusion-related acute lung injury: incidence and risk factors. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group . Blood . Nov 23, 2011 Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome. Matthay MA, Kallet RH . Critical care (London, England) . Oct 25, 2011 Acute lung failure. Mac Sweeney R, McAuley DF, Matthay MA . Seminars in respiratory and critical care medicine . Oct 11, 2011 Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT . American journal of respiratory and critical care medicine . Sep 1, 2011 Physiology, reductionism, and translational medicine: the right mix. Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevens T, Ware LB . American journal of physiology. Lung cellular and molecular physiology . Aug 19, 2011 Clinical review: Thinking outside the box--an iconoclastic view of current practice. Singer M, Matthay MA . Critical care (London, England) . Jul 26, 2011 Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA . The American journal of pathology . Jul 8, 2011 Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA, California Transplant Donor Network . Annals of intensive care . Jun 14, 2011 Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD . Annals of intensive care . Jun 13, 2011 Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA . Stem cells (Dayton, Ohio) . Jun 1, 2011 Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA . Critical care research and practice . May 29, 2011 Mesenchymal stem cells and acute lung injury. Gotts JE, Matthay MA . Critical care clinics . May 23, 2011 An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM, Acute Lung Injury in Animals Study Group . American journal of respiratory cell and molecular biology . May 1, 2011 Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Matthay MA, Liu KD . American journal of respiratory and critical care medicine . May 1, 2011 Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay MA, Kallet RH . Respiratory research . Apr 22, 2011 Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ . American journal of physiology. Lung cellular and molecular physiology . Apr 15, 2011 Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Cross LJ, Matthay MA . Critical care clinics . Apr 1, 2011 Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA, National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network . Critical Care Medicine . Apr 1, 2011 Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ . American journal of respiratory and critical care medicine . Mar 18, 2011 Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, NIH NHLBI ARDS Network . Critical care (London, England) . Mar 7, 2011 Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA . Inflammation research : official journal of the European Histamine Research Society ... [et al.] . Feb 8, 2011 Informed consent in research to improve the number and quality of deceased donor organs. Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD . Critical Care Medicine . Feb 1, 2011 Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA, DOGMATIC Study Investigators . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Feb 1, 2011 Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Yamakawa N, Uchida T, Matthay MA, Makita K . American journal of physiology. Lung cellular and molecular physiology . Jan 21, 2011 Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA . The Journal of biological chemistry . Jan 19, 2011 Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS . Critical Care Medicine . Jan 1, 2011 The acute respiratory distress syndrome: pathogenesis and treatment. Matthay MA, Zemans RL . Annual review of pathology . Jan 1, 2011 Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA . Stem cells (Dayton, Ohio) . Dec 1, 2010 Stem cells in sepsis and acute lung injury. Cribbs SK, Matthay MA, Martin GS . Critical Care Medicine . Dec 1, 2010 The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition. Levitt JE, Matthay MA . Expert review of respiratory medicine . Dec 1, 2010 Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Lee JS, Su X, Rackley C, Matthay MA, Gupta N . Anatomical record (Hoboken, N.J. : 2007) . Nov 16, 2010 Mesenchymal stem cells for acute lung injury: preclinical evidence. Matthay MA, Goolaerts A, Howard JP, Lee JW . Critical Care Medicine . Oct 1, 2010 Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW . Chest . Oct 1, 2010 Thinking outside the box: Introduction. Singer M, Matthay MA . Critical Care Medicine . Oct 1, 2010 The influence of race on the development of acute lung injury in trauma patients. Brown LM, Kallet RH, Matthay MA, Dicker RA . American journal of surgery . Sep 15, 2010 Pathophysiology of transfusion-related acute lung injury. Looney MR, Gilliss BM, Matthay MA . Current opinion in hematology . Sep 1, 2010 Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD . Critical Care Medicine . Sep 1, 2010 Assessing the quantity of pulmonary edema in critically ill children. McAuley DF, Brown LM, Matthay MA . Critical care (London, England) . Aug 13, 2010 Advances and challenges in translating stem cell therapies for clinical diseases. Matthay MA . Translational research : the journal of laboratory and clinical medicine . Aug 4, 2010 Alveolar fluid clearance is faster in women with acute lung injury compared to men. Bastarache JA, Ong T, Matthay MA, Ware LB . Journal of critical care . Aug 4, 2010 Acute lung injury: epidemiology, pathogenesis, and treatment. Johnson ER, Matthay MA . Journal of aerosol medicine and pulmonary drug delivery . Aug 1, 2010 Acute respiratory distress syndrome after surgery: can the risk be decreased? Matthay MA, Jayr C . Anesthesia and analgesia . Aug 1, 2010 Therapeutic strategies for severe acute lung injury. Diaz JV, Brower R, Calfee CS, Matthay MA . Critical Care Medicine . Aug 1, 2010 Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. Fang X, Neyrinck AP, Matthay MA, Lee JW . The Journal of biological chemistry . Jun 16, 2010 Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD . Critical Care Medicine . Jun 1, 2010 Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR . Critical Care Medicine . Jun 1, 2010 Update on acute lung injury and critical care medicine 2009. Matthay MA, Idell S . American journal of respiratory and critical care medicine . May 15, 2010 Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB . The Journal of trauma . May 1, 2010 Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS . American journal of physiology. Lung cellular and molecular physiology . Apr 23, 2010 Regulated gene expression in cultured type II cells of adult human lung. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 9, 2010 Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF . Thorax . Apr 1, 2010 Simulation of lung alveolar epithelial wound healing in vitro. Kim SH, Matthay MA, Mostov K, Hunt CA . Journal of the Royal Society, Interface . Mar 17, 2010 Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF . Proceedings of the National Academy of Sciences of the United States of America . Mar 15, 2010 Clinical immunology: Culprits with evolutionary ties. Calfee CS, Matthay MA . Nature . Mar 4, 2010 Standards and recommendations for quantitative assessment of lung structure in research. Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Feb 26, 2010 Measuring the quantity of pulmonary edema in clinical lung injury. Brown LM, Matthay MA . Critical Care Medicine . Jan 1, 2010 Thirty years of critical care medicine. Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB . Critical care (London, England) . Jan 1, 2010 Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF . The Journal of biological chemistry . Dec 8, 2009 Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Abman SH, Matthay MA . American journal of respiratory and critical care medicine . Dec 1, 2009 Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. Su X, Matthay MA, Malik AB . Journal of immunology (Baltimore, Md. : 1950) . Nov 30, 2009 Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S . Intensive care medicine . Nov 26, 2009 Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H . Pediatric pulmonology . Nov 1, 2009 Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, NHLBI ARDS Clinical Trials Network . Chest . Oct 26, 2009 Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Sapru A, Curley MA, Brady S, Matthay MA, Flori H . Intensive care medicine . Oct 24, 2009 Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA . The Journal of clinical investigation . Oct 5, 2009 Potential application of mesenchymal stem cells in acute lung injury. Lee JW, Gupta N, Serikov V, Matthay MA . Expert opinion on biological therapy . Oct 1, 2009 Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA . The European respiratory journal . Sep 9, 2009 Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA . Proceedings of the National Academy of Sciences of the United States of America . Aug 31, 2009 Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF . American journal of respiratory cell and molecular biology . Aug 28, 2009 Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR . Critical care (London, England) . Aug 11, 2009 NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C . American journal of respiratory and critical care medicine . Aug 6, 2009 Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Brown LM, Liu KD, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 17, 2009 Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. McAuley DF, Matthay MA . Chest . Jun 1, 2009 Inhaled activated protein C: a novel therapy for acute lung injury? Liu KD, Looney MR, Matthay MA . Critical care (London, England) . May 21, 2009 Protective mechanisms of activated protein C in severe inflammatory disorders. Neyrinck AP, Liu KD, Howard JP, Matthay MA . British journal of pharmacology . May 14, 2009 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J . Anesthesiology . May 1, 2009 Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Church GD, Matthay MA, Liu K, Milet M, Flori HR . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . May 1, 2009 Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD . Pediatric pulmonology . May 1, 2009 Recent trends in acute lung injury mortality: 1996-2005. Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD, NIH NHLBI ARDS Network . Critical Care Medicine . May 1, 2009 Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Su X, Looney MR, Gupta N, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 1, 2009 Mesenchymally "stemming" angiogenesis. Matthay MA . Blood . Apr 30, 2009 Neutrophil sandwiches injure the microcirculation. Looney MR, Matthay MA . Nature Medicine . Apr 1, 2009 Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Su X, Matthay MA . Anatomical record (Hoboken, N.J. : 2007) . Apr 1, 2009 Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF . American journal of respiratory and critical care medicine . Mar 26, 2009 A computational approach to understand in vitro alveolar morphogenesis. Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA . PloS one . Mar 13, 2009 The pathogenetic and prognostic value of biologic markers in acute lung injury. Levitt JE, Gould MK, Ware LB, Matthay MA . Journal of intensive care medicine . Mar 11, 2009 Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA . Chest . Feb 2, 2009 The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Neyrinck AP, Matthay MA . Critical Care Medicine . Feb 1, 2009 Racial and ethnic disparities in mortality from acute lung injury. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD, National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress S . Critical Care Medicine . Jan 1, 2009 Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK . American journal of respiratory cell and molecular biology . Dec 23, 2008 Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA . Free radical biology & medicine . Dec 14, 2008 Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA . Chest . Nov 18, 2008 Beyond fishing: the role of discovery proteomics in mechanistic lung research. Ware LB, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Nov 14, 2008 Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Looney MR, Esmon CT, Matthay MA . Thorax . Nov 13, 2008 Reasons for nonenrollment in a clinical trial of acute lung injury. Glassberg AE, Luce JM, Matthay MA, National Heart, Lung, and Blood Institute Clinical Trials Network . Chest . Aug 8, 2008 Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network . Intensive care medicine . Aug 1, 2008 Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA, NHLBI ARDS Network . Thorax . Jun 19, 2008 Predictors of mortality in acute lung injury during the era of lung protective ventilation. Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH . Thorax . Jun 19, 2008 Randomized clinical trial of activated protein C for the treatment of acute lung injury. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA . American journal of respiratory and critical care medicine . Jun 19, 2008 Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA . Critical Care Medicine . Jun 1, 2008 CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . May 15, 2008 Novel molecular strategy to prevent pulmonary edema. Matthay MA, Berthiaume Y . Critical Care Medicine . May 1, 2008 Measurement of extravascular lung water in patients with pulmonary edema. Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 25, 2008 Protein C as a surrogate end-point for clinical trials of sepsis. Liu KD, Matthay MA . Critical care (London, England) . Apr 24, 2008 Treatment of acute lung injury: clinical and experimental studies. Matthay MA . Proceedings of the American Thoracic Society . Apr 15, 2008 Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Matthay MA, Calfee CS . Chest . Apr 1, 2008 Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB . Critical care (London, England) . Mar 21, 2008 Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA . Lung . Mar 21, 2008 A framework and mechanistically focused, in silico method for enabling rational translational research. Hunt CA, Baranzini S, Matthay MA, Park S . Summit on translational bioinformatics . Mar 1, 2008 Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Matthay MA, Lee J . Thorax . Mar 1, 2008 Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB . American journal of physiology. Lung cellular and molecular physiology . Feb 29, 2008 Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF . Circulation research . Feb 14, 2008 Advances in critical care for the nephrologist: acute lung injury/ARDS. Liu KD, Matthay MA . Clinical journal of the American Society of Nephrology : CJASN . Jan 16, 2008 Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA . Journal of immunology (Baltimore, Md. : 1950) . Jan 1, 2008 Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group . Critical Care Medicine . Dec 1, 2007 Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA . Tissue engineering . Oct 1, 2007 The role of protein C in sepsis. Looney MR, Matthay MA . Current infectious disease reports . Oct 1, 2007 Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, Acute Respiratory Distress Syndrome Network, National Heart, Lung, and Blood Institute . Critical Care Medicine . Oct 1, 2007 Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Frank JA, Pittet JF, Wray C, Matthay MA . Thorax . Sep 27, 2007 Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE . American journal of physiology. Renal physiology . Sep 5, 2007 Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA . Anatomical record (Hoboken, N.J. : 2007) . Sep 1, 2007 Surfactant treatment of aspiration-induced lung injury in children. Matthay MA, Taeusch W . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Sep 1, 2007 Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . Aug 1, 2007 Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Networ . Critical Care Medicine . Aug 1, 2007 Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM . Inhalation toxicology . Aug 1, 2007 Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Jul 1, 2007 Pulmonary barriers to pneumonia and sepsis. Matthay MA, Su X . Nature Medicine . Jul 1, 2007 Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA . The Journal of biological chemistry . Jun 19, 2007 Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA . Chest . Jun 15, 2007 Alveolar edema fluid clearance and acute lung injury. Berthiaume Y, Matthay MA . Respiratory physiology & neurobiology . May 21, 2007 Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK . American journal of physiology. Lung cellular and molecular physiology . May 18, 2007 Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF . Annals of surgery . May 1, 2007 MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM . American journal of physiology. Lung cellular and molecular physiology . May 1, 2007 Genomics and proteomics of lung disease: conference summary. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 27, 2007 Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA . American journal of respiratory cell and molecular biology . Apr 12, 2007 Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Fremont RD, Kallet RH, Matthay MA, Ware LB . Chest . Apr 5, 2007 Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA . American journal of respiratory and critical care medicine . Mar 15, 2007 The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB . Thorax . Mar 13, 2007 Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Mar 9, 2007 Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Flori HR, Ware LB, Milet M, Matthay MA . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Mar 1, 2007 Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K . Molecular biology of the cell . Mar 1, 2007 Nonventilatory treatments for acute lung injury and ARDS. Calfee CS, Matthay MA . Chest . Mar 1, 2007 Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Frank JA, Parsons PE, Matthay MA . Chest . Dec 1, 2006 Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA . Clinics in chest medicine . Dec 1, 2006 Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM . American journal of respiratory cell and molecular biology . Nov 10, 2006 Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB . American journal of respiratory cell and molecular biology . Nov 10, 2006 Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA . Nature Medicine . Nov 5, 2006 Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network . American journal of respiratory and critical care medicine . Nov 2, 2006 Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF . American journal of respiratory cell and molecular biology . Nov 1, 2006 Protein permeability in lung injury: now in real time again? Lee JW, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 26, 2006 Treatment of acute lung injury: historical perspective and potential future therapies. Levitt JE, Matthay MA . Seminars in respiratory and critical care medicine . Aug 1, 2006 Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 28, 2006 Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF . FASEB journal : official publication of the Federation of American Societies for Experimental Biology . Jun 22, 2006 Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA . Intensive care medicine . Jun 13, 2006 Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Wiener-Kronish JP, Matthay MA . Critical Care Medicine . Jun 1, 2006 Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Gupta N, Matthay MA . Critical Care Medicine . Jun 1, 2006 Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D . The Journal of clinical investigation . May 18, 2006 Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA . The Journal of clinical investigation . May 18, 2006 Higher urine desmosine levels are associated with mortality in patients with acute lung injury. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network . American journal of physiology. Lung cellular and molecular physiology . May 12, 2006 Integrating acute lung injury and regulation of alveolar fluid clearance. Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 12, 2006 Evolving practices in critical care and potential implications for management of acute kidney injury. Liu KD, Matthay MA, Chertow GM . Clinical journal of the American Society of Nephrology : CJASN . May 10, 2006 Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF . American journal of physiology. Lung cellular and molecular physiology . May 5, 2006 Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA . American journal of respiratory cell and molecular biology . May 1, 2006 Animal models of transfusion-related acute lung injury. Looney MR, Matthay MA . Critical Care Medicine . May 1, 2006 Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. Cepkova M, Matthay MA . Journal of intensive care medicine . May 1, 2006 Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 28, 2006 Perspectives, translational research, and letters to the editor. Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB . American journal of physiology. Lung cellular and molecular physiology . Apr 1, 2006 Alveolar epithelial ion and fluid transport: recent progress. Folkesson HG, Matthay MA . American journal of respiratory cell and molecular biology . Mar 2, 2006 Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL, Pediatric Prone Positioning Study Group . Journal of critical care . Mar 1, 2006 Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA . Critical Care Medicine . Mar 1, 2006 Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU . Molecular & cellular proteomics : MCP . Feb 24, 2006 Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA . American journal of respiratory and critical care medicine . Feb 2, 2006 Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Matthay MA, Abraham E . American journal of respiratory and critical care medicine . Feb 1, 2006 Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Looney MR, Matthay MA . Critical care (London, England) . Jan 1, 2006 Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Cepkova M, Brady S, Sapru A, Matthay MA, Church G . Critical care (London, England) . Jan 1, 2006 Clinical practice. Acute pulmonary edema. Ware LB, Matthay MA . The New England journal of medicine . Dec 29, 2005 TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M . Journal of immunology (Baltimore, Md. : 1950) . Dec 15, 2005 Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Su X, Robriquet L, Folkesson HG, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Nov 11, 2005 Therapeutic value of a lung protective ventilation strategy in acute lung injury. Matthay MA, Calfee CS . Chest . Nov 1, 2005 Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA . American journal of physiology. Lung cellular and molecular physiology . Oct 7, 2005 Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Matthay MA, Zimmerman GA . American journal of respiratory cell and molecular biology . Oct 1, 2005 High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA . The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation . Oct 1, 2005 Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Sep 2, 2005 Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . Aug 15, 2005 Leukotrienes in acute lung injury: a potential therapeutic target? Frank JA, Matthay MA . American journal of respiratory and critical care medicine . Aug 1, 2005 Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH . JAMA . Jul 13, 2005 VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA . The European respiratory journal . Jul 1, 2005 Recent advances in mechanical ventilation. Calfee CS, Matthay MA . The American journal of medicine . Jun 1, 2005 Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP . American journal of respiratory cell and molecular biology . May 12, 2005 Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Kallet RH, Daniel BM, Garcia O, Matthay MA . Respiratory care . Apr 1, 2005 Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Mar 18, 2005 Critical care in AJRCCM 2004. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E . American journal of respiratory and critical care medicine . Mar 15, 2005 Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF . The Journal of biological chemistry . Mar 8, 2005 In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B . American journal of physiology. Lung cellular and molecular physiology . Jan 28, 2005 Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA, Acute Respiratory Distress Syndrome Network . Critical Care Medicine . Jan 1, 2005 Alveolar epithelium: role in lung fluid balance and acute lung injury. Matthay MA, Robriquet L, Fang X . Proceedings of the American Thoracic Society . Jan 1, 2005 Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA . Critical Care Medicine . Jan 1, 2005 Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? McAuley DF, Matthay MA . Treatments in respiratory medicine . Jan 1, 2005 Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network . Critical Care Medicine . Jan 1, 2005 Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S . The American journal of medicine . Jan 1, 2005 Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Flori HR, Glidden DV, Rutherford GW, Matthay MA . American journal of respiratory and critical care medicine . Dec 23, 2004 Integrated control of lung fluid balance. Mehta D, Bhattacharya J, Matthay MA, Malik AB . American journal of physiology. Lung cellular and molecular physiology . Dec 1, 2004 HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF . FASEB journal : official publication of the Federation of American Societies for Experimental Biology . Nov 18, 2004 Can nicotine treat sepsis? Matthay MA, Ware LB . Nature Medicine . Nov 1, 2004 Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Parsons PE, Matthay MA, Ware LB, Eisner MD, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network . American journal of physiology. Lung cellular and molecular physiology . Oct 29, 2004 Acute lung injury and acute respiratory distress syndrome in pregnancy. Bandi VD, Munnur U, Matthay MA . Critical care clinics . Oct 1, 2004 Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Su X, Looney M, Robriquet L, Fang X, Matthay MA . Experimental lung research . Sep 1, 2004 Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Kallet RH, Alonso JA, Pittet JF, Matthay MA . Respiratory care . Sep 1, 2004 Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I . Blood . Aug 24, 2004 Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT, National Heart, Lung, and Blood Institute ARDS Clinical Trials Network . The New England journal of medicine . Jul 22, 2004 Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Sue RD, Matthay MA, Ware LB . Intensive care medicine . Jul 17, 2004 Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. McAuley DF, Frank JA, Fang X, Matthay MA . Critical Care Medicine . Jul 1, 2004 Coagulation-dependent mechanisms and asthma. Matthay MA, Clements JA . The Journal of clinical investigation . Jul 1, 2004 Proteomics: current techniques and potential applications to lung disease. Hirsch J, Hansen KC, Burlingame AL, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 1, 2004 Transfusion-related acute lung injury: a review. Looney MR, Gropper MA, Matthay MA . Chest . Jul 1, 2004 Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Zemans RL, Matthay MA . Critical care (London, England) . Jun 30, 2004 Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA . American journal of respiratory and critical care medicine . Jun 16, 2004 Plasma protein C levels in patients with acute lung injury: prognostic significance. Matthay MA, Ware LB . Critical Care Medicine . May 1, 2004 H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC . American journal of physiology. Lung cellular and molecular physiology . Apr 30, 2004 Mechanisms of alveolar protein clearance in the intact lung. Hastings RH, Folkesson HG, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Apr 1, 2004 Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Zemans RL, Chatterjee K, Matthay MA . The American journal of medicine . Mar 15, 2004 Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Fang X, Song Y, Zemans R, Hirsch J, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Feb 27, 2004 Malnutrition impairs alveolar fluid clearance in rat lungs. Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Feb 20, 2004 Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . Feb 15, 2004 Look before you leap: how do intensivists improve care for critically ill patients? Gropper MA, Matthay MA . The American journal of medicine . Feb 1, 2004 Why does acute lung injury have no impact on mortality in patients with major trauma? McClintock DE, Matthay MA . Critical Care Medicine . Feb 1, 2004 Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C . The Journal of biological chemistry . Jan 26, 2004 Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW . American journal of physiology. Lung cellular and molecular physiology . Jan 23, 2004 Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Krupa A, Kato H, Matthay MA, Kurdowska AK . American journal of physiology. Lung cellular and molecular physiology . Jan 16, 2004 Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA . Experimental lung research . Jan 1, 2004 The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN . Infection and immunity . Jan 1, 2004 Cytokine-mediated inflammation in acute lung injury. Goodman RB, Pugin J, Lee JS, Matthay MA . Cytokine & growth factor reviews . Dec 1, 2003 Pancreatitis-associated acute lung injury: new insights. Pastor CM, Matthay MA, Frossard JL . Chest . Dec 1, 2003 Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport. Clerici C, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Dec 1, 2003 Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury. Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay MA, Christensen PJ . The American journal of pathology . Dec 1, 2003 Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D, ARDS Clinical Trials Network, National Heart, Lung, and Blood Institute, National Institutes of Heal . Critical Care Medicine . Nov 1, 2003 Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Eisner MD, Parsons P, Matthay MA, Ware L, Greene K, Acute Respiratory Distress Syndrome Network . Thorax . Nov 1, 2003 Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA . Intensive care medicine . Oct 14, 2003 Acute lung injury and the acute respiratory distress syndrome. Cheng IW, Matthay MA . Critical care clinics . Oct 1, 2003 Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S . American journal of physiology. Lung cellular and molecular physiology . Sep 5, 2003 Pulmonary edema fluid antioxidants are depressed in acute lung injury. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ . Critical Care Medicine . Sep 1, 2003 Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs. Olman MA, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Sep 1, 2003 Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF . The Journal of biological chemistry . Aug 20, 2003 Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R . American journal of respiratory and critical care medicine . Jul 3, 2003 Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Flori HR, Ware LB, Glidden D, Matthay MA . Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . Jul 1, 2003 Protein C and thrombomodulin in human acute lung injury. Ware LB, Fang X, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 16, 2003 Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA . American journal of physiology. Lung cellular and molecular physiology . May 2, 2003 Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL . American journal of respiratory and critical care medicine . Apr 1, 2003 Therapeutic strategies to hasten the resolution of pulmonary edema. Folkesson HG, Matthay MA . Critical Care Medicine . Apr 1, 2003 Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Collard HR, Saint S, Matthay MA . Annals of internal medicine . Mar 18, 2003 Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP . Experimental cell research . Feb 15, 2003 High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jan 31, 2003 Prognostic value of surfactant proteins A and D in patients with acute lung injury. Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA . Critical Care Medicine . Jan 1, 2003 Alveolar fluid clearance in patients with ARDS: does it make a difference? Matthay MA . Chest . Dec 1, 2002 Clinical measurement of pulmonary edema. Matthay MA . Chest . Dec 1, 2002 Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. Berthiaume Y, Folkesson HG, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Dec 1, 2002 Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Brower RG, Matthay M, Schoenfeld D . American journal of respiratory and critical care medicine . Dec 1, 2002 Alveolar epithelial fluid transport in acute lung injury: new insights. Sartori C, Matthay MA . The European respiratory journal . Nov 1, 2002 Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB . The American journal of pathology . Nov 1, 2002 Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C . American journal of physiology. Lung cellular and molecular physiology . Nov 1, 2002 Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Nov 1, 2002 Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Nov 1, 2002 Measuring microvascular blood flow in sepsis--a continuing challenge. Ware LB, Matthay MA . Lancet (London, England) . Oct 19, 2002 Science review: mechanisms of ventilator-induced injury. Frank JA, Matthay MA . Critical care (London, England) . Oct 16, 2002 Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. Planès C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C . The Journal of biological chemistry . Oct 7, 2002 Central line infections. Lane RK, Matthay MA . Current opinion in critical care . Oct 1, 2002 Invited review: Active fluid clearance from the distal air spaces of the lung. Matthay MA, Clerici C, Saumon G . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 2002 Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs. Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay MA . The Journal of thoracic and cardiovascular surgery . Oct 1, 2002 Ventilator-induced lung injury: in vivo and in vitro mechanisms. Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R . American journal of physiology. Lung cellular and molecular physiology . Oct 1, 2002 Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 30, 2002 Assessment of lungs rejected for transplantation and implications for donor selection. Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M . Lancet (London, England) . Aug 24, 2002 The pulmonary epithelium is an important mediator of ventilator-induced lung injury. Matthay MA . Critical Care Medicine . Aug 1, 2002 Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. Fang X, Yang B, Matthay MA, Verkman AS . The Journal of physiology . Jul 1, 2002 Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB . American journal of physiology. Lung cellular and molecular physiology . Jul 1, 2002 Lung epithelial fluid transport and the resolution of pulmonary edema. Matthay MA, Folkesson HG, Clerici C . Physiological reviews . Jul 1, 2002 Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Saint S, Savel RH, Matthay MA . American journal of respiratory and critical care medicine . Jun 1, 2002 Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA . Intensive care medicine . May 17, 2002 Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 1, 2002 Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Ware LB, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . May 1, 2002 The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Atabai K, Matthay MA . Thorax . May 1, 2002 Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA . The New England journal of medicine . Apr 25, 2002 Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA, Acute Respiratory Distress Syndrome Network . American journal of respiratory and critical care medicine . Apr 1, 2002 Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome. Matthay MA, Uchida T, Fang X . Current treatment options in cardiovascular medicine . Apr 1, 2002 Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines. Folkesson HG, Matthay MA, Chapin CJ, Porta NF, Kitterman JA . American journal of physiology. Lung cellular and molecular physiology . Mar 1, 2002 Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA . Chest . Mar 1, 2002 Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA . Anesthesiology . Feb 1, 2002 Novel role for CFTR in fluid absorption from the distal airspaces of the lung. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA . The Journal of general physiology . Feb 1, 2002 Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA . American journal of respiratory and critical care medicine . Jan 15, 2002 Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ . The Journal of physiology . Jan 15, 2002 von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Ware LB, Conner ER, Matthay MA . Critical Care Medicine . Dec 1, 2001 Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS. Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE . Chest . Nov 1, 2001 Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C . American journal of respiratory cell and molecular biology . Nov 1, 2001 Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Oswari J, Matthay MA, Margulies SS . American journal of physiology. Lung cellular and molecular physiology . Nov 1, 2001 Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB . American journal of physiology. Lung cellular and molecular physiology . Oct 1, 2001 The Role of Protein C in Sepsis. Looney MR, Matthay MA . Current infectious disease reports . Oct 1, 2001 Treatment of ARDS. Brower RG, Ware LB, Berthiaume Y, Matthay MA . Chest . Oct 1, 2001 Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA, Acute Respiratory Distress Syndrome Network . American journal of respiratory and critical care medicine . Jul 15, 2001 Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung. Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Inoue M, Matthay MA . Experimental lung research . Jul 1, 2001 Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. Fischer H, Fukuda N, Barbry P, Illek B, Sartori C, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jul 1, 2001 Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis. Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA . Chest . Jul 1, 2001 Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium. Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Jun 1, 2001 Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS . The Journal of general physiology . Jun 1, 2001 TGF-beta is a critical mediator of acute lung injury. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D . The Journal of clinical investigation . Jun 1, 2001 Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . May 15, 2001 Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Ware LB, Matthay MA . American journal of respiratory and critical care medicine . May 1, 2001 Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA . American journal of respiratory and critical care medicine . May 1, 2001 Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats. Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG . Journal of applied physiology (Bethesda, Md. : 1985) . Apr 1, 2001 Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN . Cellular microbiology . Apr 1, 2001 Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties. Matthay MA . The New England journal of medicine . Mar 8, 2001 Alveolar epithelial transport. Basic science to clinical medicine. Crandall ED, Matthay MA . American journal of respiratory and critical care medicine . Mar 1, 2001 Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs. Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Kurihara T, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Jan 1, 2001 Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Yost CS, Matthay MA, Gropper MA . Chest . Jan 1, 2001 Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S . American journal of respiratory and critical care medicine . Jan 1, 2001 Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema. Sartori C, Matthay MA, Scherrer U . Advances in experimental medicine and biology . Jan 1, 2001 Interleukin-1beta augments in vitro alveolar epithelial repair. Geiser T, Jarreau PH, Atabai K, Matthay MA . American journal of physiology. Lung cellular and molecular physiology . Dec 1, 2000 Role of aquaporin water channels in pleural fluid dynamics. Song Y, Yang B, Matthay MA, Ma T, Verkman AS . American journal of physiology. Cell physiology . Dec 1, 2000 Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. Frank JA, Wang Y, Osorio O, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 2000 Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T . Clinics in chest medicine . Sep 1, 2000 Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies. Fukuda N, Folkesson HG, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 2000 Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Frank JA, Nuckton TJ, Matthay MA . Critical Care Medicine . Jul 1, 2000 Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS . The Journal of physiology . Jun 15, 2000 Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly. Jasmer RM, Matthay MA . Critical Care Medicine . Jun 1, 2000 Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG . American journal of respiratory cell and molecular biology . Jun 1, 2000 Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs. Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA . Transplantation . May 15, 2000 The acute respiratory distress syndrome. Ware LB, Matthay MA . The New England journal of medicine . May 4, 2000 Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A . The New England journal of medicine . May 4, 2000 Aquaporin water channels and lung physiology. Verkman AS, Matthay MA, Song Y . American journal of physiology. Lung cellular and molecular physiology . May 1, 2000 Hypoxia regulates gene expression of alveolar epithelial transport proteins. Clerici C, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . May 1, 2000 [Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin]. Coscoy S, de Weille J, Lingueglia E, Fukuda N, Matthay M, Lazdunski M, Barbry P . Annales d'endocrinologie . May 1, 2000 Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV . American journal of respiratory and critical care medicine . Apr 1, 2000 A novel alveolar type I cell-specific biochemical marker of human acute lung injury. Newman V, Gonzalez RF, Matthay MA, Dobbs LG . American journal of respiratory and critical care medicine . Mar 1, 2000 Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation. Pascual FE, Matthay MA, Bacchetti P, Wachter RM . Chest . Feb 1, 2000 Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Feb 1, 2000 Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS . The Journal of biological chemistry . Jan 28, 2000 Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE . Critical Care Medicine . Jan 1, 2000 Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development. Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P . American journal of physiology. Lung cellular and molecular physiology . Jan 1, 2000 Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF . Critical Care Medicine . Jan 1, 2000 Lung fluid transport in aquaporin-5 knockout mice. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS . The Journal of clinical investigation . Jan 1, 2000 Noninvasive ventilation for acute respiratory failure. Jasmer RM, Matthay MA . Journal of clinical monitoring and computing . Jan 1, 2000 Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. Song Y, Ma T, Matthay MA, Verkman AS . The Journal of general physiology . Jan 1, 2000 Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy. Kallet RH, Alonso JA, Luce JM, Matthay MA . Chest . Dec 1, 1999 Health-related quality of life after acute lung injury. Eisner MD, Matthay MA . Critical Care Medicine . Dec 1, 1999 Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA . American journal of respiratory and critical care medicine . Nov 1, 1999 Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Nov 1, 1999 Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits. Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM . American journal of respiratory and critical care medicine . Nov 1, 1999 Interobserver variability in applying a radiographic definition for ARDS. Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA . Chest . Nov 1, 1999 Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. Verghese GM, Ware LB, Matthay BA, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 1999 The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages. Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R . European journal of immunology . Oct 1, 1999 alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF . The American journal of physiology . Oct 1, 1999 Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats. Berthiaume Y, Folkesson HG, Matthay MA . Experimental lung research . Sep 1, 1999 Oxidant-mediated lung injury in the acute respiratory distress syndrome. Matthay MA, Geiser T, Matalon S, Ischiropoulos H . Critical Care Medicine . Sep 1, 1999 Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC . Chest . Jul 1, 1999 Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms. Wang Y, Jayr C, Folkesson HG, Matthay MA . Chest . Jul 1, 1999 Conference summary: acute lung injury. Matthay MA . Chest . Jul 1, 1999 Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance. Conner ER, Ware LB, Modin G, Matthay MA . Chest . Jul 1, 1999 HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Newman V, Gonzalez R, Matthay M, Dobbs L . Chest . Jul 1, 1999 Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock. Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF . The American journal of physiology . May 1, 1999 Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Ware LB, Golden JA, Finkbeiner WE, Matthay MA . American journal of respiratory and critical care medicine . Mar 1, 1999 The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D . Cell . Feb 5, 1999 Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS . The Journal of clinical investigation . Feb 1, 1999 The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Pugin J, Verghese G, Widmer MC, Matthay MA . Critical Care Medicine . Feb 1, 1999 Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep. Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Jan 1, 1999 Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection. Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA . The American journal of physiology . Jan 1, 1999 Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS . The American journal of physiology . Jan 1, 1999 Role of collagenase in mediating in vitro alveolar epithelial wound repair. Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP . Journal of cell science . Jan 1, 1999 Risk reduction in the intensive care unit. Saint S, Matthay MA . The American journal of medicine . Dec 1, 1998 Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Matthay MA, Flori HR, Conner ER, Ware LB . Proceedings of the Association of American Physicians . Nov 1, 1998 Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA . American journal of obstetrics and gynecology . Oct 1, 1998 Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA . The American journal of physiology . Sep 1, 1998 Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA . American journal of respiratory and critical care medicine . Aug 1, 1998 Protective ventilation for the acute respiratory distress syndrome. Parsons PE, Matthay M . The New England journal of medicine . Jul 16, 1998 A mouse model to test the in vivo efficacy of chemical chaperones. Bai C, Biwersi J, Verkman AS, Matthay MA . Journal of pharmacological and toxicological methods . Jul 1, 1998 Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung. Sakuma T, Takahashi K, Ohya N, Nakada T, Matthay MA . Pharmacology & toxicology . Jul 1, 1998 Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Ma T, Yang B, Matthay MA, Verkman AS . American journal of respiratory cell and molecular biology . Jul 1, 1998 New in situ mouse model to quantify alveolar epithelial fluid clearance. Garat C, Carter EP, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . May 1, 1998 High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Carter EP, Olveczky BP, Matthay MA, Verkman AS . Biophysical journal . Apr 1, 1998 The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM . Intensive care medicine . Apr 1, 1998 The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM . American journal of respiratory and critical care medicine . Apr 1, 1998 Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS . Proceedings of the National Academy of Sciences of the United States of America . Mar 17, 1998 Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome. Matthay MA, Pittet JF, Jayr C . Critical Care Medicine . Jan 1, 1998 Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung. Carter EP, Umenishi F, Matthay MA, Verkman AS . The Journal of clinical investigation . Sep 1, 1997 Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Chesnutt AN, Matthay MA, Tibayan FA, Clark JG . American journal of respiratory and critical care medicine . Sep 1, 1997 Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA . American journal of respiratory and critical care medicine . Aug 1, 1997 Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats. Modelska K, Matthay MA, McElroy MC, Pittet JF . The American journal of physiology . Aug 1, 1997 Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. Folkesson HG, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Jun 1, 1997 Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Jasmer RM, Luce JM, Matthay MA . Chest . Jun 1, 1997 Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats. Garat C, Meignan M, Matthay MA, Luo DF, Jayr C . Chest . May 1, 1997 Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Smith WS, Matthay MA . Chest . May 1, 1997 Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Oliver BL, Garat C, Pytela R, Matthay MA . American journal of respiratory cell and molecular biology . May 1, 1997 Biological markers of acute lung injury: prognostic and pathogenetic significance. Pittet JF, Mackersie RC, Martin TR, Matthay MA . American journal of respiratory and critical care medicine . Apr 1, 1997 Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA . Chest . Mar 1, 1997 Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA . American journal of respiratory and critical care medicine . Feb 1, 1997 Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C . The Journal of clinical investigation . Jan 15, 1997 Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis. Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA . Surgery today . Jan 1, 1997 Sharp increase in rat lung water channel expression in the perinatal period. Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS . American journal of respiratory cell and molecular biology . Nov 1, 1996 Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA . The American journal of physiology . Nov 1, 1996 Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB . Journal of immunology (Baltimore, Md. : 1950) . Sep 15, 1996 Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Miller EJ, Cohen AB, Matthay MA . Critical Care Medicine . Sep 1, 1996 Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. Carter EP, Matthay MA, Farinas J, Verkman AS . The Journal of general physiology . Sep 1, 1996 Acid aspiration induced lung injury. New insights and therapeutic options. Matthay MA, Rosen GD . American journal of respiratory and critical care medicine . Aug 1, 1996 Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats. Pittet JF, Brenner TJ, Modelska K, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 1996 Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats. Folkesson HG, Pittet JF, Nitenberg G, Matthay MA . The American journal of physiology . Aug 1, 1996 The acute respiratory distress syndrome. Matthay MA . The New England journal of medicine . May 30, 1996 Alveolar epithelial clearance of protein. Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH . Journal of applied physiology (Bethesda, Md. : 1985) . May 1, 1996 Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia. Sakuma T, Suzuki S, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . May 1, 1996 Pulmonary edema in a woman following fetal surgery. DiFederico EM, Harrison M, Matthay MA . Chest . Apr 1, 1996 Salt and water transport across alveolar and distal airway epithelia in the adult lung. Matthay MA, Folkesson HG, Verkman AS . The American journal of physiology . Apr 1, 1996 Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. Folkesson HG, Matthay MA, Frigeri A, Verkman AS . The Journal of clinical investigation . Feb 1, 1996 Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM . The Journal of experimental medicine . Jan 1, 1996 Alveolar endotoxin increases alveolar liquid clearance in rats. Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay MA, Jayr C . Journal of applied physiology (Bethesda, Md. : 1985) . Dec 1, 1995 Identification of patients with acute lung injury. Predictors of mortality. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA . American journal of respiratory and critical care medicine . Dec 1, 1995 Cellular uptake of albumin from lungs of anesthetized rabbits. Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA . The American journal of physiology . Oct 1, 1995 Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. Folkesson HG, Matthay MA, Hébert CA, Broaddus VC . The Journal of clinical investigation . Jul 1, 1995 Evaluation of definitions of ARDS. Rubenfeld GD, Doyle RL, Matthay MA . American journal of respiratory and critical care medicine . Apr 1, 1995 Resistance of the alveolar epithelium to injury from septic shock in sheep. Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA . American journal of respiratory and critical care medicine . Apr 1, 1995 Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Schwartz DE, Matthay MA, Cohen NH . Anesthesiology . Feb 1, 1995 Frequency and importance of barotrauma in 100 patients with acute lung injury. Schnapp LM, Chin DP, Szaflarski N, Matthay MA . Critical Care Medicine . Feb 1, 1995 Fibrosing alveolitis in the adult respiratory distress syndrome. Matthay MA . Annals of internal medicine . Jan 1, 1995 The effect of salt water on alveolar epithelial barrier function. Folkesson HG, Kheradmand F, Matthay MA . American journal of respiratory and critical care medicine . Dec 1, 1994 Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA . The American journal of physiology . Dec 1, 1994 Alveolar fluid clearance in the resected human lung. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA . American journal of respiratory and critical care medicine . Aug 1, 1994 Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA . The Journal of clinical investigation . Aug 1, 1994 Alveolar liquid and protein clearance in anesthetized ventilated rats. Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Jun 1, 1994 Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS . Proceedings of the National Academy of Sciences of the United States of America . May 24, 1994 Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA . The American journal of physiology . May 1, 1994 Function of the alveolar epithelial barrier under pathologic conditions. Matthay MA . Chest . Mar 1, 1994 Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS . The Journal of biological chemistry . Feb 25, 1994 Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Kelly BJ, Matthay MA . Chest . Dec 1, 1993 Alveolar epithelial barrier and acute lung injury. Matthay MA, Folkesson HG, Campagna A, Kheradmand F . New horizons (Baltimore, Md.) . Nov 1, 1993 Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B . Journal of cell science . Nov 1, 1993 Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 1993 Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP . The Journal of clinical investigation . Sep 1, 1993 Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. Serikov VB, Grady M, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 1993 Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA . The American journal of physiology . May 1, 1993 Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP . Chest . Apr 1, 1993 Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA . Journal of immunology (Baltimore, Md. : 1950) . Jan 15, 1993 Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. Sakuma T, Pittet JF, Jayr C, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Jan 1, 1993 Clearance of different-sized proteins from the alveolar space in humans and rabbits. Hastings RH, Grady M, Sakuma T, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 1992 Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Espiritu RF, Pittet JF, Matthay MA, Goetzl EJ . Inflammation . Oct 1, 1992 Pulmonary edema associated with salt water near-drowning: new insights. Cohen DS, Matthay MA, Cogan MG, Murray JF . The American review of respiratory disease . Sep 1, 1992 Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD . The New England journal of medicine . Aug 20, 1992 Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay MA . The American review of respiratory disease . Aug 1, 1992 Obstetric patients requiring critical care. A five-year review. Kilpatrick SJ, Matthay MA . Chest . May 1, 1992 Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Callaham M, Barton C, Matthay M . Critical Care Medicine . Mar 1, 1992 Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. Jayr C, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Nov 1, 1991 Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. Wiener-Kronish JP, Albertine KH, Matthay MA . The Journal of clinical investigation . Sep 1, 1991 Critical care medicine. Matthay MA, Matthay RA . JAMA . Jun 19, 1991 Alveolar and lung liquid clearance in anesthetized rabbits. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Apr 1, 1991 Resolution of pulmonary edema. New insights. Matthay MA . The Western journal of medicine . Mar 1, 1991 Right-heart catheterization is a diagnostic procedure not a therapeutic intervention. Chatterjee K, Matthay M . Journal of intensive care medicine . Mar 1, 1991 Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Matthay MA, Wiener-Kronish JP . The American review of respiratory disease . Dec 1, 1990 Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Wiedemann HP, Matthay MA, Gillis CN . Clinics in chest medicine . Dec 1, 1990 The adult respiratory distress syndrome. Definition and prognosis. Matthay MA . Clinics in chest medicine . Dec 1, 1990 Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA . The Journal of clinical investigation . Aug 1, 1990 The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Wiener-Kronish JP, Gropper MA, Matthay MA . British journal of anaesthesia . Jul 1, 1990 Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA . Anesthesiology . Apr 1, 1990 The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". Heffner JE, Matthay MA . The Journal of laboratory and clinical medicine . Apr 1, 1990 Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Segredo V, Matthay MA, Sharma ML, Gruenke LD, Caldwell JE, Miller RD . Anesthesiology . Mar 1, 1990 Pulmonary manifestations of endocrine and metabolic disorders. Brüssel T, Matthay MA, Chernow B . Clinics in chest medicine . Dec 1, 1989 Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA . The Journal of clinical investigation . Nov 1, 1989 Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Nov 1, 1989 New modes of mechanical ventilation for ARDS. How should they be evaluated? Matthay MA . Chest . Jun 1, 1989 Ureteral obstruction caused by vasculitis. Baskin L, Mee S, Matthay M, Carroll PR . The Journal of urology . Apr 1, 1989 Respiratory management after cardiac surgery. Matthay MA, Wiener-Kronish JP . Chest . Feb 1, 1989 The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. Matthay MA . The Western journal of medicine . Feb 1, 1989 Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay MA, Crystal RG . Proceedings of the National Academy of Sciences of the United States of America . Jan 1, 1989 Bedside catheterization of the pulmonary artery: risks compared with benefits. Matthay MA, Chatterjee K . Annals of internal medicine . Nov 15, 1988 Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC . The Journal of clinical investigation . Oct 1, 1988 An expanded definition of the adult respiratory distress syndrome. Murray JF, Matthay MA, Luce JM, Flick MR . The American review of respiratory disease . Sep 1, 1988 Alveolar liquid and protein clearance from normal dog lungs. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA . Journal of applied physiology (Bethesda, Md. : 1985) . Aug 1, 1988 Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA . Radiology . Jul 1, 1988 Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. Ratnoff WD, Matthay MA, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ . Journal of clinical immunology . Jul 1, 1988 Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Wiener-Kronish JP, Matthay MA . Chest . Apr 1, 1988 Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA . Chest . Dec 1, 1987 Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Dean NC, Amend WC, Matthay MA . Chest . Apr 1, 1987 Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. Berthiaume Y, Staub NC, Matthay MA . The Journal of clinical investigation . Feb 1, 1987 The adult respiratory distress syndrome. Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA . The Yale journal of biology and medicine . Nov 1, 1986 Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS . Chest . Sep 1, 1986 Central intravascular pressure measurements: when should we believe them? Gates LM, Matthay MA . Journal of thoracic imaging . Jul 1, 1986 Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Fein A, Wiener-Kronish JP, Niederman M, Matthay MA . Critical care clinics . Jul 1, 1986 Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K . Anesthesiology . Jun 1, 1986 Clinical spectrum of pulmonary mucormycosis. Bigby TD, Serota ML, Tierney LM, Matthay MA . Chest . Mar 1, 1986 Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass. Swerdlow BN, Mihm FG, Goetzl EJ, Matthay MA . Anesthesia and analgesia . Mar 1, 1986 Pulmonary embolism. Guide to diagnosis, treatment, and prevention. Broaddus C, Matthay MA . Postgraduate medicine . Mar 1, 1986 Intensive care unit: how stressful for physicians? Eisendrath SJ, Link N, Matthay M . Critical Care Medicine . Feb 1, 1986 Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC . The American review of respiratory disease . Dec 1, 1985 Cellular basis for injury and repair in the adult respiratory distress syndrome. Matthay MA . The Western journal of medicine . Nov 1, 1985 Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. Matthay MA, Berthiaume Y, Staub NC . Journal of applied physiology (Bethesda, Md. : 1985) . Sep 1, 1985 Pathophysiology of pulmonary edema. Matthay MA . Clinics in chest medicine . Sep 1, 1985 Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung. Matthay MA . Clinics in chest medicine . Sep 1, 1985 Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA . American heart journal . Aug 1, 1985 Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF . The American review of respiratory disease . Nov 1, 1984 Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. Matthay MA, Eschenbacher WL, Goetzl EJ . Journal of clinical immunology . Nov 1, 1984 Neurogenic pulmonary edema. Colice GL, Matthay MA, Bass E, Matthay RA . The American review of respiratory disease . Nov 1, 1984 Morphologic and physiologic correlates of increased extravascular lung water. Bongard FS, Matthay M, Mackersie RC, Lewis FR . Surgery . Aug 1, 1984 Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Wiedemann HP, Matthay MA, Matthay RA . Chest . May 1, 1984 Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Wiedemann HP, Matthay MA, Matthay RA . Chest . Apr 1, 1984 Guillain-Barré syndrome: psychosocial aspects of management. Eisendrath SJ, Matthay MA, Dunkel JA, Zimmerman JK, Layzer RB . Psychosomatics . May 1, 1983 Hemodynamic management in the adult respiratory distress syndrome. Prewitt RM, Matthay MA, Ghignone M . Clinics in chest medicine . May 1, 1983 Invasive hemodynamic monitoring in critically ill patients. Matthay MA . Clinics in chest medicine . May 1, 1983 Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC . Circulation research . Mar 1, 1983 Differential liquid and protein clearance from the alveoli of anesthetized sheep. Matthay MA, Landolt CC, Staub NC . Journal of applied physiology: respiratory, environmental and exercise physiology . Jul 1, 1982 Adult respiratory distress syndrome complicating diabetic ketoacidosis. Russell J, Follansbee S, Matthay M . The Western journal of medicine . Aug 1, 1981 Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep. Landolt CC, Matthay MA, Staub NC . Journal of applied physiology: respiratory, environmental and exercise physiology . Jun 1, 1981 Chest mass with pleurisy. Matthay MA, Addison TE, Ellinger G, Choy SH, Kaltreider HB . Chest . Oct 1, 1979 Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV . The Journal of clinical endocrinology and metabolism . Mar 1, 1978 Acute pseudogout in the absence of synovial fluid Leukocytes. Matthay M, Lindamood M, Steigerwald JC, Solomons C . The Journal of rheumatology . Jan 1, 1977 Hypertrophic osteoarthropathy in adults with cystic fibrosis. Matthay MA, Matthay RA, Mills DM, Lakshminarayan S, Cotton E . Thorax . Oct 1, 1976 Grand mal seizure induced by oral theophylline. Matthay RA, Matthay MA, Weinberger MM . Thorax . Aug 1, 1976
