Biography Dr. Michael Gropper has been Professor and Chair of the UCSF Department of Anesthesia and Perioperative Care since 2015. In addition to being the Chair, Dr. Gropper is also a Professor of Physiology and an Investigator in the UCSF Cardiovascular Research Institute. He has received numerous honors and awards with the most recent of becoming a Distinguished Professor. Dr. Gropper received his PhD in Physiology from UCSF, and his medical degree from UCLA. He returned to UCSF and completed a residency in anesthesia and fellowship in critical care medicine. Dr. Gropper is internationally known for his work in improving outcomes in critically ill patients and has spearheaded successful efforts to reduce hospital-acquired harms in the ICU and operating room. His research interests are acute respiratory failure, severe sepsis, transfusion lung injury, and ICU teamwork and communication. Role Faculty Location UCSF at Mission Bay UCSF at Mount Zion UCSF at Parnassus Category Clinical Education 2018 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaFellowship, 1994 - Critical Care Medicine, UCSFResidency, 1993 - Anesthesiology, University of California, San FranciscoM.D., 1989 - School of Medicine, University of California Los AngelesPh.D., 1985 - Graduate Division (Physiology), University of California, San Francisco Publications A Least Absolute Shrinkage and Selection Operator-Derived Predictive Model for Postoperative Respiratory Failure in a Heterogeneous Adult Elective Surgery Patient Population. Stocking JC, Taylor SL, Fan S, Wingert T, Drake C, Aldrich JM, Ong MK, Amin AN, Marmor RA, Godat L, Cannesson M, Gropper MA, Utter GH, Sandrock CE, Bime C, Mosier J, Subbian V, Adams JY, Kenyon NJ, Albertson TE, Garcia JGN, Abraham I Outcomes and risk factors for delayed-onset postoperative respiratory failure: a multi-center case-control study by the University of California Critical Care Research Collaborative (UC3RC). Stocking JC, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS, Sandrock C, Bime C, Abraham I, Utter GH Quality of Life Improvement: A Novel Framework and Approach to Well-Being. Sinskey JL, Chang JM, Nicholau D, Gropper MA Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. Hughes CG, Mailloux PT, Devlin JW, Swan JT, Sanders RD, Anzueto A, Jackson JC, Hoskins AS, Pun BT, Orun OM, Raman R, Stollings JL, Kiehl AL, Duprey MS, Bui LN, O'Neal HR, Snyder A, Gropper MA, Guntupalli KK, Stashenko GJ, Patel MB, Brummel NE, Girard TD, Dittus RS, Bernard GR, Ely EW, Pandharipande PP, MENDS2 Study Investigators Risk Factors Associated With Early Postoperative Respiratory Failure: A Matched Case-Control Study. Stocking JC, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS, Utter GH Consensus-based perioperative protocols during the COVID-19 pandemic. Mummaneni PV, Burke JF, Chan AK, Sosa JA, Lobo EP, Mummaneni VP, Antrum S, Berven SH, Conte MS, Doernberg SB, Goldberg AN, Hess CP, Hetts SW, Josephson SA, Kohi MP, Ma CB, Mahadevan VS, Molinaro AM, Murr AH, Narayana S, Roberts JP, Stoller ML, Theodosopoulos PV, Vail TP, Wienholz S, Gropper MA, Green A, Berger MS Postoperative respiratory failure: An update on the validity of the Agency for Healthcare Research and Quality Patient Safety Indicator 11 in an era of clinical documentation improvement programs. Stocking JC, Utter GH, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS Heterogeneity in Intensive Care: Low Severity Does Not Mean Low Risk! Pirracchio R, Gropper MA Developing a Comprehensive Model of Intensive Care Unit Processes: Concept of Operations. Romig M, Tropello SP, Dwyer C, Wyskiel RM, Ravitz A, Benson J, Gropper MA, Pronovost PJ, Sapirstein A Intensive care unit providers more quickly and accurately assess risk of multiple harms using an engineered safety display. Romig M, Carolan H, Ravitz A, Schell-Chaple H, Yoon E, Dwyer C, Thornton K, Gropper M, Pronovost PJ, Sapirstein A Interprofessional Care and Teamwork in the ICU. Donovan AL, Aldrich JM, Gross AK, Barchas DM, Thornton KC, Schell-Chaple HM, Gropper MA, Lipshutz AKM, University of California, San Francisco Critical Care Innovations Group Dr Ted Eger Obituary. Gropper MA, Shafer SL Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families. Thornton KC, Schwarz JJ, Gross AK, Anderson WG, Liu KD, Romig MC, Schell-Chaple H, Pronovost PJ, Sapirstein A, Gropper MA, Lipshutz AKM, Project Emerge Collaborators Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care. Detsky AS, Gropper MA An Ethnographic Study of Health Information Technology Use in Three Intensive Care Units. Leslie M, Paradis E, Gropper MA, Kitto S, Reeves S, Pronovost P Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care. Detsky AS, Gropper MA A Typology of ICU Patients and Families from the Clinician Perspective: Toward Improving Communication. Leslie M, Paradis E, Gropper MA, Milic MM, Kitto S, Reeves S, Pronovost P The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III. Lipshutz AK, Feiner JR, Grimes B, Gropper MA IV Immunoglobulin: A Useful Tool for the Severe Pneumonia Toolbox? Crowley JC, Gropper MA Intensive Care Unit-acquired Muscle Weakness: An Ounce of Prevention Is Worth a Pound of Cure. Lipshutz AK, Gropper MA Interprofessional rhetoric and operational realities: an ethnographic study of rounds in four intensive care units. Paradis E, Leslie M, Gropper MA A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB An analysis of near misses identified by anesthesia providers in the intensive care unit. Lipshutz AK, Caldwell JE, Robinowitz DL, Gropper MA Preoperative medical testing in Medicare patients undergoing cataract surgery. Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group Delivering interprofessional care in intensive care: a scoping review of ethnographic studies. Paradis E, Leslie M, Puntillo K, Gropper M, Aboumatar HJ, Kitto S, Reeves S Say no to old blood*. Gilliss BM, Gropper MA Applying ethnography to the study of context in healthcare quality and safety. Leslie M, Paradis E, Gropper MA, Reeves S, Kitto S ICU early mobilization: from recommendation to implementation at three medical centers. Engel HJ, Needham DM, Morris PE, Gropper MA Interprofessional care in intensive care settings and the factors that impact it: results from a scoping review of ethnographic studies. Paradis E, Leslie M, Gropper MA, Aboumatar HJ, Kitto S, Reeves S Exploring the nature of interprofessional collaboration and family member involvement in an intensive care context. Paradis E, Reeves S, Leslie M, Aboumatar H, Chesluk B, Clark P, Courtenay M, Franck L, Lamb G, Lyndon A, Mesman J, Puntillo K, Schmitt M, van Soeren M, Wachter B, Zwarenstein M, Gropper M, Kitto S Postoperative respiratory muscle dysfunction: only the strong survive. Gropper MA Risk factors and outcomes in transfusion-associated circulatory overload. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group Acquired neuromuscular weakness and early mobilization in the intensive care unit. Lipshutz AK, Gropper MA Challenge of assessing symptoms in seriously ill intensive care unit patients: can proxy reporters help? Puntillo KA, Neuhaus J, Arai S, Paul SM, Gropper MA, Cohen NH, Miaskowski C Central venous catheters: follow the evidence, not the guidelines. Lipshutz AK, Gropper MA Organ donation after cardiac death in amyotrophic lateral sclerosis. Toossi S, Lomen-Hoerth C, Josephson SA, Gropper MA, Roberts J, Patton K, Smith WS Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA Transfusion-related acute lung injury: incidence and risk factors. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group Reducing noninfectious risks of blood transfusion. Gilliss BM, Looney MR, Gropper MA Prediction is very difficult, especially about the future-Niels Bohr. Donovan AL, Gropper MA Critical care issues in patients after liver transplantation. Razonable RR, Findlay JY, O'Riordan A, Burroughs SG, Ghobrial RM, Agarwal B, Davenport A, Gropper M Symptoms experienced by intensive care unit patients at high risk of dying. Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C Special article: rescue therapies for acute hypoxemic respiratory failure. Liu LL, Aldrich JM, Shimabukuro DW, Sullivan KR, Taylor JM, Thornton KC, Gropper MA Can we predict pulmonary complications after thoracic surgery? Aldrich JM, Gropper MA Ventilator-associated pneumonia in a neurologic intensive care unit does not lead to increased mortality. Josephson SA, Moheet AM, Gropper MA, Nichols AD, Smith WS Looking forward, looking back: assessing variations in hospital resource use and outcomes for elderly patients with heart failure. Ong MK, Mangione CM, Romano PS, Zhou Q, Auerbach AD, Chun A, Davidson B, Ganiats TG, Greenfield S, Gropper MA, Malik S, Rosenthal JT, Escarce JJ Critical care checklists, the Keystone Project, and the Office for Human Research Protections: a case for streamlining the approval process in quality-improvement research. Savel RH, Goldstein EB, Gropper MA Noisy mechanical ventilation: listen to the melody. Shimabukuro DW, Gropper MA Perioperative glycemic control: an evidence-based review. Lipshutz AK, Gropper MA Postoperative infectious complications of abdominal solid organ transplantation. Hlava N, Niemann CU, Gropper MA, Melcher ML Laboratory testing guidelines in the intensive care unit: less red and more green. Sullivan K, Gropper MA Strategies for success: A PDSA analysis of three QI initiatives in critical care. Lipshutz AK, Fee C, Schell H, Campbell L, Taylor J, Sharpe BA, Nguyen J, Gropper MA The curse of the drinking class. Yost CS, Gropper MA Tracheostomy protocol compliance: herding cats? Liu L, Gropper MA The epithelium in acute lung injury/acute respiratory distress syndrome. Gropper MA, Wiener-Kronish J Multisystem organ failure: predicting the future. Gropper MA Critical care challenges in orthopedic surgery patients. Taylor JM, Gropper MA Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Gajic O, Gropper MA, Hubmayr RD Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R Establishing a comprehensive, evidence-based protocol for the care of patients with sepsis. Fee C, Gropper MA Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococci. Guglielmo BJ, Dudas V, Maewal I, Young R, Hilts A, Villmann M, Gibbs L, Gropper M, Jacobs R Evidence-based management of critically ill patients: analysis and implementation. Gropper MA Transfusion-related acute lung injury: a review. Looney MR, Gropper MA, Matthay MA Look before you leap: how do intensivists improve care for critically ill patients? Gropper MA, Matthay MA Sepsis and hypothermia: call in the granulocytes? Gropper MA Injury and repair in lung and airways. Shimabukuro DW, Sawa T, Gropper MA Predicting mortality in acute respiratory distress syndrome: circulatory system knows best. Misset B, Gropper MA, Wiener-Kronish JP Postoperative analgesia and sedation in the adult intensive care unit: a guide to drug selection. Liu LL, Gropper MA The alveolar epithelium: suspect or innocent bystander? Gropper MA, Wiener-Kronish J Respiratory and Hemodynamic Management After Cardiac Surgery. Liu LL, Gropper MA A momentary pause... Gropper MA Protective effects of low tidal volume ventilation in a rabbit model of Pseudomonas aeruginosa-induced acute lung injury. Savel RH, Yao EC, Gropper MA Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Yost CS, Matthay MA, Gropper MA Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Sawa T, Kurahashi K, Ohara M, Gropper MA, Doshi V, Larrick JW, Wiener-Kronish JP In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA, Wiener-Kronish JP Halogenated anesthetics and the injured lung: clouds on the horizon? Wiener-Kronish JP, Gropper MA Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production. Ohara M, Sawa T, Kurahashi K, Wiener-Kronish JP, Doshi V, Kudoh I, Gropper MA IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia. Sawa T, Corry DB, Gropper MA, Ohara M, Kurahashi K, Wiener-Kronish JP Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay. Umenishi F, Verkman AS, Gropper MA Intraluminal water increases expression of plasmid DNA in rat lung. Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Frigeri A, Gropper MA, Turck CW, Verkman AS Acute cardiogenic pulmonary edema. Gropper MA, Wiener-Kronish JP, Hashimoto S Pulmonary arterial and venous constriction during hypoxia in 3- to 5-wk-old and adult ferrets. Raj JU, Hillyard R, Kaapa P, Gropper M, Anderson J The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Wiener-Kronish JP, Gropper MA, Matthay MA [Estimation of the filtration variables in the rat lung]. Tanita T, Gropper MA, Staub NC, Koike K, Nakada T Lung expansion and the perialveolar interstitial pressure gradient. Bhattacharya J, Gropper MA, Shepard JM Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC Alveolar liquid and protein clearance from normal dog lungs. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA Filtration profile in isolated zone 1 and zone 3 dog lungs at constant high alveolar pressure. Gropper MA, Bhattacharya J, Staub NC Lung microvascular pressure profile measured by micropuncture in anesthetized dogs. Shepard JM, Gropper MA, Nicolaysen G, Staub NC, Bhattacharya J Direct measurement of blood pressure within the long hypophysial portal blood vessels. Findell PR, Mulchahey JJ, Shepard JM, Gropper MA, Battacharya J, Weiner RI Pleural liquid pressure in dogs measured using a rib capsule. Wiener-Kronish JP, Gropper MA, Lai-Fook SJ Interstitial fluid pressure gradient measured by micropuncture in excised dog lung. Bhattacharya J, Gropper MA, Staub NC Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC Effect of lung inflation on alveolar-airway barrier protein permeability in dog lung. Conhaim RL, Gropper MA, Staub NC
