Biography I was born in South Africa and obtained my medical degree with honors from the University of Cape Town in 1070. I emigrated from apartheid-era South Africa after my junior doctor training at Groote Schuur Hospital, Cape Town, and subsequently trained in internal medicine at the Royal Free Hospital, London England. I continued my training as a postdoctoral research fellow at Stanford University where I completed my residency in anesthesia in 1981. After joining the faculty in the Department of Anesthesia at Stanford, I received successive promotions to become a tenured professor and Vice-Chair for Research. In 1999, I was recruited to become the Magill Professor of Anaesthesia at Imperial College, London and subsequently became the Chair of Surgery, Oncology, Reproductive Biology and Anesthesia at Imperial College. In 2009, I was recruited to become the Chair of Anesthesia and Perioperative Care at UCSF which I held for 5 years before transitioning to full-time research at the Zuckerberg San Francisco General, the county-hospital campus for UCSF. My career in sponsored research began under the tutelage of Dame Sheila Sherlock in 1974 and has been a major focus of my academic activities for more than 50 years. During that time, I have been funded and led laboratories at Stanford, Imperial College, and UCSF. I have published more than 300 peer-reviewed publications and received several national and international awards for my research. According to Google Scholar (accessed 7-29-25), my h-index is 104 and I have over 42,000 citations. I have been married to Janet Wyner MD for 56 years and have two children (Brad and Jacqui) and 6 grand-children. Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Education Residency, 1981 - Anesthesia, Stanford University, Department of AnesthesiaPostdoctoral Research Fellow, 1979 - Medicine, Stanford University, Department of MedicineRegistrar, 1976 - Medicine, Royal Free HospitalInternship, Resident Medical Officer, 1972 - Medicine, Groote Schuur Hospital, Cape Town, S. AfricaMB,ChB, 1970 - Bachelor of Medicine (Honors) Bachelor of Surgery (Honors), University of Cape Town, South Africa Publications Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration. Leng K, Maze M, Barreto Chang OL Frontiers in aging neuroscience . Aug 29, 2025 Alpha-2 adrenergic agonists in Anesthesiology Buttermann AE, Maze M Seminars in Anesthesia . Aug 19, 2025 A comparison of large language model-generated and published perioperative neurocognitive disorder recommendations: a cross-sectional web-based analysis. Saxena S, Barreto Chang OL, Suppan M, Meco BC, Vacas S, Radtke F, Matot I, Devos A, Maze M, Gisselbaek M, Berger-Estilita J British journal of anaesthesia . Feb 7, 2025 Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized Non-inferiority trial. Fang PP, Hu J, Wei QF, Liang YJ, Fan YG, Shen QY, Lu Y, Liu XS, Maze M, REMPPOD study collaborators International journal of surgery (London, England) . Jul 11, 2024 Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial. Hollmén C, Parkkola R, Vorobyev V, Saunavaara J, Laitio R, Arola O, Hynninen M, Bäcklund M, Martola J, Ylikoski E, Roine RO, Tiainen M, Scheinin H, Maze M, Vahlberg T, Laitio TT Neurocritical care . Jul 9, 2024 The role of cultural competency training to address health disparities in surgical settings. Mora R, Maze M British medical bulletin . Mar 11, 2024 ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z Clinical and translational medicine . Apr 1, 2024 Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings. Langnas E, Maze M Handbook of experimental pharmacology . Jan 5, 2024 Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD British journal of anaesthesia . Jun 27, 2023 High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy. DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S Cells . Apr 4, 2023 Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI bioRxiv : the preprint server for biology . Apr 3, 2023 Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J BMC anesthesiology . Mar 16, 2023 Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies. Barreto Chang OL, Maze M Frontiers in aging neuroscience . Jan 26, 2023 Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M British journal of anaesthesia . Dec 8, 2022 Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M Anesthesia and analgesia . Oct 26, 2022 Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial. Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT, XeHYPOTHECA Research Group Neuroradiology . Oct 17, 2022 Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M British journal of anaesthesia . Oct 15, 2022 Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M Medical hypotheses . Sep 21, 2022 Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets. Barreto Chang OL, Possin KL, Maze M Annual review of pharmacology and toxicology . Sep 13, 2022 Considerations for the implementation of machine learning into acute care settings. Bishara A, Maze EH, Maze M British medical bulletin . Mar 21, 2022 Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia. Hu J, Zhang Y, Maze M European journal of anaesthesiology . Mar 1, 2022 Early postoperative risk prediction of neurocognitive decline. Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J British journal of anaesthesia . Jan 29, 2022 Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD Critical Care Medicine . Oct 1, 2021 Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators JAMA network open . Oct 1, 2021 High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders. Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M Cells . Sep 28, 2021 Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial. Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T Critical care explorations . Jul 29, 2021 The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders. Saxena S, Kruys V, Vamecq J, Maze M Frontiers in aging neuroscience . May 28, 2021 Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M European journal of anaesthesiology . Mar 1, 2021 Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study. Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J BMC anesthesiology . Nov 14, 2020 Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award. Pearce RA, Maze M Anesthesiology . Oct 1, 2020 Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Li R, Lai IK, Pan JZ, Zhang P, Maze M Anesthesiology . Aug 1, 2020 Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M British journal of anaesthesia . Jul 2, 2020 Perioperative Neurocognitive Disorder: State of the Preclinical Science. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF Anesthesiology . Jan 1, 2020 Neuroprotective Properties of Xenon. Maze M, Laitio T Molecular neurobiology . Nov 22, 2019 Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ British journal of anaesthesia . Oct 14, 2019 Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D Annals of surgery . Aug 1, 2019 Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. Rylova A, Maze M Journal of neurosurgical anesthesiology . Jan 1, 2019 Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders? Li R, Lai IK, Maze M British journal of anaesthesia . Dec 24, 2018 Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group Anesthesia and analgesia . Dec 1, 2018 Diagnostic accuracy of leptospirosis whole-cell lateral flow assays: a systematic review and meta-analysis. Maze MJ, Sharples KJ, Allan KJ, Rubach MP, Crump JA Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . Nov 23, 2018 Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M Anesthesiology . May 1, 2018 Restoring Order to Postoperative Neurocognitive Disorders. Saxena S, Uchida Y, Maze M JAMA neurology . May 1, 2018 Impact on the brain of the inflammatory response to surgery. Saxena S, Maze M Presse medicale (Paris, France : 1983) . Apr 12, 2018 Past, present, and future of nitrous oxide. Lew V, McKay E, Maze M British medical bulletin . Mar 1, 2018 Methods for Defining the Neuroprotective Properties of Xenon. Robel R, Caroccio P, Maze M Methods in enzymology . Feb 27, 2018 The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Maze MJ, Bassat Q, Feasey NA, Mandomando I, Musicha P, Crump JA Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases . Feb 15, 2018 Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M British journal of anaesthesia . Feb 3, 2018 Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M Frontiers in immunology . Dec 11, 2017 Perioperative management of the obese surgical patient. Lang LH, Parekh K, Tsui BYK, Maze M British medical bulletin . Dec 1, 2017 Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T, Xe-HYPOTHECA Study Group Journal of the American College of Cardiology . Nov 28, 2017 The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. Coburn M, Sanders RD, Maze M, Nguyên-Pascal ML, Rex S, Garrigues B, Carbonell JA, Garcia-Perez ML, Stevanovic A, Kienbaum P, Neukirchen M, Schaefer MS, Borghi B, van Oven H, Tognù A, Al Tmimi L, Eyrolle L, Langeron O, Capdevila X, Arnold GM, Schaller M, Rossaint R, HIPELD Study Investigators British journal of anaesthesia . Nov 21, 2017 In Response. Vacas S, Maze M Anesthesia and analgesia . Aug 1, 2017 The immune response of the human brain to abdominal surgery. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI Annals of neurology . Apr 11, 2017 Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK JCI Insight . Apr 6, 2017 Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D Neurotoxicology and teratology . Jan 6, 2017 Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction. Vacas S, Degos V, Maze M Anesthesia and analgesia . Jan 1, 2017 Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1. Vacas S, Maze M Journal of clinical & cellular immunology . Dec 26, 2016 "A Time of Opportunity": Patient Safety and the Perioperative Surgical Home. Garson LM, Vakharia S, Edwards AF, Maze M Anesthesia and analgesia . Dec 1, 2016 From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Maze M Anesthesiology . Sep 1, 2016 Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM Journal of neuroinflammation . Aug 30, 2016 Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D Lancet (London, England) . Aug 16, 2016 The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM Anesthesia and analgesia . Jul 1, 2016 Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand. Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease . Jul 1, 2016 Correction: Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H PloS one . Mar 17, 2016 Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T JAMA . Mar 15, 2016 Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings? Maze M, Pirracchio R Anesthesia and analgesia . Mar 1, 2016 Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD The Lancet. Neurology . Dec 19, 2015 Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review. Maze M Canadian journal of anaesthesia = Journal canadien d'anesthesie . Oct 27, 2015 Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M Brain, behavior, and immunity . Jul 8, 2015 Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. Feng X, Maze M, Koch LG, Britton SL, Hellman J PloS one . May 15, 2015 Preoperative medical testing in Medicare patients undergoing cataract surgery. Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA The New England journal of medicine . Apr 16, 2015 Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T Journal of neuroimmunology . Apr 2, 2015 Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M Molecular medicine (Cambridge, Mass.) . Mar 17, 2015 In reply. Vacas S, Degos V, Maze M Anesthesiology . Dec 1, 2014 Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H PloS one . Aug 26, 2014 Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. Han Z, Li L, Wang L, Degos V, Maze M, Su H Journal of neurochemistry . Aug 4, 2014 Endoglin deficiency impairs stroke recovery. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H Stroke . May 29, 2014 High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Vacas S, Degos V, Tracey KJ, Maze M Anesthesiology . May 1, 2014 Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Bozic KJ, Ward L, Vail TP, Maze M Clinical orthopaedics and related research . Jan 1, 2014 Take off, landing, and fly anesthesia. Sanders RD, Maze M PLoS genetics . Sep 5, 2013 Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT Critical Care Medicine . Sep 1, 2013 Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T Critical Care Medicine . Jul 1, 2013 Bone fracture exacerbates murine ischemic cerebral injury. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H Anesthesiology . Jun 1, 2013 Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M Anesthesiology . May 1, 2013 The neuroinflammatory response of postoperative cognitive decline. Vacas S, Degos V, Feng X, Maze M British medical bulletin . Apr 4, 2013 G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P Annals of neurology . Mar 14, 2013 Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M Anesthesiology . Mar 1, 2013 Sleep and Anesthesia - Common mechanisms of action. Vacas S, Kurien P, Maze M Sleep medicine clinics . Mar 1, 2013 Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M Molecular medicine (Cambridge, Mass.) . Feb 8, 2013 Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T Influenza and other respiratory viruses . Dec 24, 2012 Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS Anesthesiology . Dec 1, 2012 Noradrenergic trespass in anesthetic and sedative states. Sanders RD, Maze M Anesthesiology . Nov 1, 2012 The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery. Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators Trials . Sep 27, 2012 Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D PloS one . May 17, 2012 Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation. Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M Annals of surgery . May 1, 2012 Reprogramming of the infant brain by surgery with general anesthesia. Culley DJ, Maze M, Crosby G Mayo Clinic proceedings . Feb 1, 2012 Resolving postoperative neuroinflammation and cognitive decline. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M Annals of neurology . Dec 1, 2011 Sedation & immunomodulation. Sanders RD, Hussell T, Maze M Anesthesiology clinics . Dec 1, 2011 N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation. Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M Archiv der Pharmazie . Nov 14, 2011 Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D PloS one . Nov 3, 2011 Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D Neurobiology of disease . Oct 29, 2011 Perioperative cognitive decline in the aging population. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M Mayo Clinic proceedings . Sep 1, 2011 Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF, Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop The Journal of pediatrics . Aug 27, 2011 Anticipating and managing postoperative delirium and cognitive decline in adults. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M BMJ (Clinical research ed.) . Jul 20, 2011 Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D Critical care (London, England) . Jun 24, 2011 Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ Annals of neurology . Jun 14, 2011 Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D Neuroscience letters . May 6, 2011 Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG Anesthesiology . Apr 1, 2011 A clinically relevant model of perinatal global ischemic brain damage in rats. Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D Brain research . Jan 31, 2011 Nucleic Acid Amplification of the opa Gene for Detection of Neisseria gonorrhoeae: experience from a diagnostic laboratory. Maze MJ, Young S, Creighton J, Anderson T, Werno A Journal of clinical microbiology . Jan 19, 2011 Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Sanders RD, Maze M Canadian journal of anaesthesia = Journal canadien d'anesthesie . Dec 18, 2010 Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D Critical Care Medicine . Nov 1, 2010 Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M Proceedings of the National Academy of Sciences of the United States of America . Nov 1, 2010 Role of interleukin-1beta in postoperative cognitive dysfunction. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M Annals of neurology . Sep 1, 2010 Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D Anesthesiology . Aug 1, 2010 Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M Anesthesiology . Jul 1, 2010 Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D Experimental biology and medicine (Maywood, N.J.) . May 14, 2010 The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M Critical care (London, England) . May 14, 2010 Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Cattano D, Valleggi S, Abramo A, Forfori F, Maze M, Giunta F Minerva anestesiologica . Apr 12, 2010 Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators Critical care (London, England) . Mar 16, 2010 Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Bantel C, Maze M, Trapp S Anesthesiology . Mar 1, 2010 Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I Anesthesiology . Mar 1, 2010 Argon neuroprotection. Sanders RD, Ma D, Maze M Critical care (London, England) . Feb 22, 2010 Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic? Sanders RD, Maze M European journal of anaesthesiology . Jan 1, 2010 Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion. Limatola V, Ward P, Cattano D, Gu J, Giunta F, Maze M, Ma D Neuroscience . Nov 4, 2009 Does correcting the numbers improve long-term outcome? Sanders RD, Maze M Anesthesiology . Sep 1, 2009 Sedation improves early outcome in severely septic Sprague Dawley rats. Qiao H, Sanders RD, Ma D, Wu X, Maze M Critical care (London, England) . Aug 19, 2009 Sedation & immunomodulation. Sanders RD, Hussell T, Maze M Critical care clinics . Jul 1, 2009 Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D Neuroscience letters . Jun 7, 2009 Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M Anesthesiology . May 1, 2009 Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Bantel C, Maze M, Trapp S Anesthesiology . May 1, 2009 The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP The Journal of neuroscience : the official journal of the Society for Neuroscience . Feb 18, 2009 Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M Journal of the American Society of Nephrology : JASN . Jan 14, 2009 Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M Anesthesiology . Nov 1, 2008 Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Sanders RD, Weimann J, Maze M Anesthesiology . Oct 1, 2008 Xenon up-regulates several genes that are not up-regulated by nitrous oxide. Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F Journal of neurosurgical anesthesiology . Oct 1, 2008 Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity. Sanders RD, Ma D, Brooks P, Maze M British journal of anaesthesia . Sep 16, 2008 Expecting the unexpected. Talke PO, Maze M Anesthesia and analgesia . Jun 1, 2008 General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M Anesthesia and analgesia . Jun 1, 2008 Role of endogenous sleep-wake and analgesic systems in anesthesia. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB The Journal of comparative neurology . Jun 1, 2008 Xenon induces transcription of ADNP in neonatal rat brain. Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F Neuroscience letters . May 28, 2008 The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Coburn M, Maze M, Franks NP Critical Care Medicine . Feb 1, 2008 Taking the lead in research into postoperative cognitive dysfunction. Maze M, Cibelli M, Grocott HP Anesthesiology . Jan 1, 2008 Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW JAMA . Dec 12, 2007 Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP Anesthesiology . Nov 1, 2007 Translational research: addressing problems facing the anesthesiologist. Sanders RD, Maze M Anesthesia and analgesia . Oct 1, 2007 Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP The Journal of biological chemistry . Jun 4, 2007 Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M Anesthesiology . Apr 1, 2007 Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Newman S, Stygall J, Hirani S, Shaefi S, Maze M Anesthesiology . Mar 1, 2007 Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M Anesthesiology . Mar 1, 2007 Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium. Maze M, Todd MM Anesthesiology . Mar 1, 2007 Adrenergic and cholinergic compounds. Sanders RD, Maze M Handbook of experimental pharmacology . Jan 1, 2007 Alpha2-adrenoceptor agonists. Sanders RD, Maze M Current opinion in investigational drugs (London, England : 2000) . Jan 1, 2007 The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K Anesthesia and analgesia . Dec 1, 2006 Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M Neuroscience letters . Oct 18, 2006 Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Preckel B, Weber NC, Sanders RD, Maze M, Schlack W Anesthesiology . Jul 1, 2006 The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat. Nekhendzy V, Davies MF, Lemmens HJ, Maze M Anesthesia and analgesia . Jun 1, 2006 A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S Anesthesiology . May 1, 2006 Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M Anesthesiology . Mar 1, 2006 Expansion of gas bubbles by nitrous oxide and xenon. Benavides R, Maze M, Franks NP Anesthesiology . Feb 1, 2006 Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . Feb 1, 2006 Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit? Pandharipande P, Ely EW, Maze M Current drug targets . Nov 1, 2005 Anaesthesia induced neuroprotection. Sanders RD, Ma D, Maze M Best practice & research. Clinical anaesthesiology . Sep 1, 2005 Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M Annals of neurology . Aug 1, 2005 Xenon and the inflammatory response to cardiopulmonary bypass in the rat. Clark JA, Ma D, Homi HM, Maze M, Grocott HP Journal of cardiothoracic and vascular anesthesia . Aug 1, 2005 Xenon: from stranger to guardian. Sanders RD, Maze M Current opinion in anaesthesiology . Aug 1, 2005 Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats. Sanders RD, Patel N, Hossain M, Ma D, Maze M British journal of anaesthesia . Jul 1, 2005 Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M Anesthesia and analgesia . May 1, 2005 Xenon: elemental anaesthesia in clinical practice. Sanders RD, Ma D, Maze M British medical bulletin . Feb 22, 2005 alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Ma D, Rajakumaraswamy N, Maze M British medical bulletin . Jan 31, 2005 Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Maze M, Angst MS Anesthesiology . Nov 1, 2004 Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M European journal of pharmacology . Oct 11, 2004 Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Angst MS, Ramaswamy B, Davies MF, Maze M Anesthesiology . Sep 1, 2004 Dexmedetomidine: another arrow for the clinician's quiver. Ebert T, Maze M Anesthesiology . Sep 1, 2004 Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Nelson LE, Franks NP, Maze M Anesthesiology . Jun 1, 2004 Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Coull JT, Jones ME, Egan TD, Frith CD, Maze M NeuroImage . May 1, 2004 Xenon exerts age-independent antinociception in Fischer rats. Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M Anesthesiology . May 1, 2004 Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Dawson C, Ma D, Chow A, Maze M Anesthesiology . Apr 1, 2004 The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M Anesthesia and analgesia . Mar 1, 2004 Xenon: no stranger to anaesthesia. Sanders RD, Franks NP, Maze M British journal of anaesthesia . Nov 1, 2003 Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats. Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M Anesthesiology . Oct 1, 2003 The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP Anesthesiology . Oct 1, 2003 Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M Anesthesiology . Sep 1, 2003 Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K Anesthesiology . Sep 1, 2003 GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats. Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M Anesthesiology . May 1, 2003 Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP Anesthesiology . Mar 1, 2003 The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M Anesthesiology . Feb 1, 2003 Evaluation of high fidelity patient simulator in assessment of performance of anaesthetists. Weller JM, Bloch M, Young S, Maze M, Oyesola S, Wyner J, Dob D, Haire K, Durbridge J, Walker T, Newble D British journal of anaesthesia . Jan 1, 2003 Evidence for the involvement of spinal cord alpha1 adrenoceptors in nitrous oxide-induced antinociceptive effects in Fischer rats. Orii R, Ohashi Y, Guo T, Nelson LE, Hashimoto T, Maze M, Fujinaga M Anesthesiology . Dec 1, 2002 Neuroprotective and neurotoxic properties of the 'inert' gas, xenon. Ma D, Wilhelm S, Maze M, Franks NP British journal of anaesthesia . Nov 1, 2002 Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats. Ohashi Y, Stowell JM, Nelson LE, Hashimoto T, Maze M, Fujinaga M Pain . Nov 1, 2002 The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M Nature neuroscience . Oct 1, 2002 Effects of xenon on in vitro and in vivo models of neuronal injury. Wilhelm S, Ma D, Maze M, Franks NP Anesthesiology . Jun 1, 2002 Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M Anesthesiology . Jun 1, 2002 Neurobiology of nitrous oxide-induced antinociceptive effects. Fujinaga M, Maze M Molecular neurobiology . Apr 1, 2002 Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M Anesthesiology . Feb 1, 2002 Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats. Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M Neuroscience letters . Jan 18, 2002 Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord. Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M Anesthesiology . Jan 1, 2002 Fetuses, fentanyl, and the stress response: signals from the beginnings of pain? Anand KJ, Maze M Anesthesiology . Oct 1, 2001 New agents for sedation in the intensive care unit. Maze M, Scarfini C, Cavaliere F Critical care clinics . Oct 1, 2001 Glucocorticoid inhibition of neuropathic limb edema and cutaneous neurogenic extravasation. Kingery WS, Guo T, Agashe GS, Davies MF, Clark JD, Maze M Brain research . Sep 21, 2001 Pharmacology of nitrous oxide Maze M, Fujinaga M Best Practice & Research Clinical Anaesthesiology . Sep 1, 2001 Nitrous oxide activates GABAergic neurons in the spinal cord in Fischer rats. Hashimoto T, Maze M, Ohashi Y, Fujinaga M Anesthesiology . Aug 1, 2001 Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors. Davies MF, Reid K, Guo TZ, Agashe GS, Amin YK, Maze M Anesthesiology . Jul 1, 2001 Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression. Kingery WS, Agashe GS, Sawamura S, Davies MF, Clark JD, Maze M Anesthesia and analgesia . Feb 1, 2001 Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M The Journal of neuroscience : the official journal of the Society for Neuroscience . Dec 15, 2000 Controversial issues in adult and paediatric ambulatory anaesthesia: is there a role for alpha-2 agonists in conscious sedation in adults and paediatric ambulatory surgical practice? Wilhelm S, Maze M Current opinion in anaesthesiology . Dec 1, 2000 Clinical uses of alpha2 -adrenergic agonists. Kamibayashi T, Maze M Anesthesiology . Nov 1, 2000 Nitrous oxide lacks the antinociceptive effect on the tail flick test in newborn rats. Fujinaga M, Doone R, Davies MF, Maze M Anesthesia and analgesia . Jul 1, 2000 Alpha2 adrenoceptors in pain modulation: which subtype should be targeted to produce analgesia? Maze M, Fujinaga M Anesthesiology . Apr 1, 2000 Recent advances in understanding the actions and toxicity of nitrous oxide. Maze M, Fujinaga M Anaesthesia . Apr 1, 2000 The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M Pain . Apr 1, 2000 Dexmedetomidine: Viewpoints Maze M, Talke P, Hassan E Drugs . Jan 1, 2000 Strain differences in the antinociceptive effect of nitrous oxide on the tail flick test in rats. Fender C, Fujinaga M, Maze M Anesthesia and analgesia . Jan 1, 2000 The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Zhang C, Davies MF, Guo TZ, Maze M Anesthesiology . Nov 1, 1999 Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Kingery WS, Castellote JM, Maze M Pain . Apr 1, 1999 Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M Anesthesiology . Feb 1, 1999 Are cholinergic pathways involved in the anesthetic response to alpha2 agonists. Buttermann AE, Reid K, Maze M Toxicology letters . Nov 23, 1998 The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors. Poree LR, Guo TZ, Kingery WS, Maze M Anesthesia and analgesia . Oct 1, 1998 Chronic desipramine treatment desensitizes the rat to anesthetic and antinociceptive effects of the alpha2-adrenergic agonist dexmedetomidine. Guo TZ, Reid K, Davies MF, Nacif-Coelho C, Rabin BC, Gonzalez F, Maze M Anesthesiology . Jun 1, 1998 Colchicine treatment of the sciatic nerve reduces neurogenic extravasation, but does not affect nociceptive thresholds or collateral sprouting in neuropathic or normal rats. Kingery WS, Guo TZ, Poree LR, Maze M Pain . Jan 1, 1998 In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE Advances in pharmacology (San Diego, Calif.) . Jan 1, 1998 Nifedipine, an L-type calcium channel blocker, restores the hypnotic response in rats made tolerant to the alpha-2 adrenergic agonist dexmedetomidine. Reid K, Guo TZ, Davies MF, Maze M The Journal of pharmacology and experimental therapeutics . Dec 1, 1997 "Exciting" aspects of opiate receptor signal transduction. Maze M Anesthesiology . Nov 1, 1997 Why does insensitivity to opioid narcotics develop? Maze M Anesthesiology . Nov 1, 1997 Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats. Fang F, Guo TZ, Davies MF, Maze M European journal of pharmacology . Oct 8, 1997 Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE Proceedings of the National Academy of Sciences of the United States of America . Sep 2, 1997 Alpha-2 adrenergic agonists. Kamibayashi T, Harasawa K, Maze M Canadian journal of anaesthesia = Journal canadien d'anesthesie . May 1, 1997 Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. Reid K, Hayashi Y, Hsu J, Maguire PA, Rabin BC, Guo TZ, Maze M Pharmacology, biochemistry, and behavior . May 1, 1997 Dissociation of hypnotic-anesthetic actions of alpha 2 agonists from cyclic AMP in the rat. Rabin BC, Guo TZ, Maze M Pharmacology, biochemistry, and behavior . May 1, 1997 Molecular Pharmacology of alpha-2 adrenoceptors; relevance to anesthesia Mizobe T; Maze M Anesthesiology clinics of North America . Jan 1, 1997 Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat. Guo TZ, Poree L, Golden W, Stein J, Fujinaga M, Maze M Anesthesiology . Oct 1, 1996 Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M The Journal of clinical investigation . Sep 1, 1996 Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats. Hayashi Y, Guo TZ, Maze M Anesthesia and analgesia . Sep 1, 1996 Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. Rabin BC, Reid K, Guo TZ, Gustafsson E, Zhang C, Maze M Anesthesiology . Sep 1, 1996 Perioperative use of alpha-2 adrenergic agonists Kamibayashi T, Maze M Current opinion in anaesthesiology . Aug 1, 1996 Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit. Kim HK, Zornow MH, Strnat MA, Maze M Journal of neurosurgical anesthesiology . Jul 1, 1996 Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Rabin BC, Guo TZ, Gregg K, Maze M European journal of pharmacology . Jun 13, 1996 Dexmedetomidine injection into the locus ceruleus produces antinociception. Guo TZ, Jiang JY, Buttermann AE, Maze M Anesthesiology . Apr 1, 1996 Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin. Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK The Journal of biological chemistry . Feb 2, 1996 Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. Seidel WF, Maze M, Dement WC, Edgar DM The Journal of pharmacology and experimental therapeutics . Oct 1, 1995 Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. Hayashi Y, Rabin BC, Guo TZ, Maze M Anesthesiology . Oct 1, 1995 Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Hayashi Y, Guo TZ, Maze M Anesthesiology . Apr 1, 1995 Alpha 2-adrenoceptor agonists and anesthesia. Mizobe T, Maze M International anesthesiology clinics . Jan 1, 1995 Anaesthetic and analgesic action of alpha-2 adrenoceptor agonists Maze M, Poree L, Rabin BC Pharmacology Communications . Jan 1, 1995 Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Nacif-Coelho C, Correa-Sales C, Chang LL, Maze M Anesthesiology . Dec 1, 1994 Chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Reid K, Hayashi Y, Guo TZ, Correa-Sales C, Nacif-Coelho C, Maze M Pharmacology, biochemistry, and behavior . Jan 1, 1994 Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses. Daunt DA, Dunlop CI, Chapman PL, Shafer SL, Ruskoaho H, Vakkuri O, Hodgson DS, Tyler LM, Maze M American journal of veterinary research . Dec 1, 1993 The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Matsumoto M, Zornow MH, Rabin BC, Maze M Brain research . Nov 12, 1993 Implementation of a radioreceptor assay for dexmedetomidine. Salonen M, Maze M Pharmacology & toxicology . Nov 1, 1993 Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Maier C, Steinberg GK, Sun GH, Zhi GT, Maze M Anesthesiology . Aug 1, 1993 Alpha 2 adrenoceptor agonists and anaesthesia. Hayashi Y, Maze M British journal of anaesthesia . Jul 1, 1993 Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Dyck JB, Maze M, Haack C, Azarnoff DL, Vuorilehto L, Shafer SL Anesthesiology . May 1, 1993 The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL Anesthesiology . May 1, 1993 Dexmedetomidine decreases cerebral blood flow velocity in humans. Zornow MH, Maze M, Dyck JB, Shafer SL Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . Mar 1, 1993 Role of imidazoline-preferring receptors in the genesis of epinephrine-induced arrhythmias in halothane-anesthetized dogs. Hayashi Y, Kamibayashi T, Maze M, Yamatodani A, Sumikawa K, Kuro M, Yoshiya I Anesthesiology . Mar 1, 1993 Molecular Pharmacology of alpha-2 adrenergic receptors Maze M, Scheinin M Anesthetic Pharmacology Review . Jan 1, 1993 Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Belleville JP, Ward DS, Bloor BC, Maze M Anesthesiology . Dec 1, 1992 Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Bloor BC, Ward DS, Belleville JP, Maze M Anesthesiology . Dec 1, 1992 Pertussis toxin-mediated ribosylation of G proteins blocks the hypnotic response to an alpha 2-agonist in the locus coeruleus of the rat. Correa-Sales C, Reid K, Maze M Pharmacology, biochemistry, and behavior . Nov 1, 1992 A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Correa-Sales C, Rabin BC, Maze M Anesthesiology . Jun 1, 1992 Synergistic interaction between alpha 2-adrenergic agonists and benzodiazepines in rats. Salonen M, Reid K, Maze M Anesthesiology . Jun 1, 1992 Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers. Jarvis DA, Duncan SR, Segal IS, Maze M Anesthesiology . Jun 1, 1992 Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Fujinaga M, Maze M, Hoffman BB, Baden JM Developmental biology . Apr 1, 1992 Clinical interactions with alpha-2-adrenergic agonists in anesthetic practice. Salonen MA, Kanto JH, Maze M Journal of clinical anesthesia . Mar 1, 1992 Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats. Salonen M, Onaivi ES, Maze M Psychopharmacology . Jan 1, 1992 A comparison of etomidate and thiopental anesthesia for cardioversion. Ford SR, Maze M, Gaba DM Journal of cardiothoracic and vascular anesthesia . Dec 1, 1991 Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: in vivo and in vitro studies. Schwinn DA, Correa-Sales C, Page SO, Maze M The Journal of pharmacology and experimental therapeutics . Dec 1, 1991 Mechanism of antiarrhythmic effect of dexmedetomidine on epinephrine-induced arrhythmias (Correspondence; Peer-Reviewed) Hayashi Y, Sumikawa K, Maze M Anesthesiology . Dec 1, 1991 Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Savola MK, Woodley SJ, Maze M, Kendig JJ Anesthesiology . Sep 1, 1991 Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Guo TZ, Tinklenberg J, Oliker R, Maze M Anesthesiology . Aug 1, 1991 Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Maze M, Virtanen R, Daunt D, Banks SJ, Stover EP, Feldman D Anesthesia and analgesia . Aug 1, 1991 Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Hayashi Y, Sumikawa K, Maze M, Yamatodani A, Kamibayashi T, Kuro M, Yoshiya I Anesthesiology . Jul 1, 1991 Attenuation of central alpha 2 adrenergic action in diabetic rats. Guo TZ, Maze B, Maze M Pharmacology, biochemistry, and behavior . Jun 1, 1991 The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Savola MK, MacIver MB, Doze VA, Kendig JJ, Maze M Brain research . May 10, 1991 Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Maze M, Tranquilli W Anesthesiology . Mar 1, 1991 Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period. Segal IS, Jarvis DJ, Duncan SR, White PF, Maze M Anesthesiology . Feb 1, 1991 Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. Kendig JJ, Savola MK, Woodley SJ, Maze M European journal of pharmacology . Jan 10, 1991 Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila. Tinklenberg JA, Segal IS, Guo TZ, Maze M Annals of the New York Academy of Sciences . Jan 1, 1991 Role of signal transduction in anesthetic action. Alpha 2 adrenergic agonists. Maze M, Regan JW Annals of the New York Academy of Sciences . Jan 1, 1991 Modulating role of dopamine on anesthetic requirements. Segal IS, Walton JK, Irwin I, DeLanney LE, Ricaurte GA, Langston JW, Maze M European journal of pharmacology . Sep 4, 1990 Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital. Doze VA, Chen BX, Tinklenberg JA, Segal IS, Maze M Anesthesiology . Aug 1, 1990 Transmembrane signalling and the holy grail of anesthesia. Maze M Anesthesiology . Jun 1, 1990 Adrenergic characteristics of the pulmonary artery "barorefelex" De Campli WM, Baldwin JC, Hagberg RC, Gaba DM, Maze M Journal of Applied Cardiology . Jan 1, 1990 The role of alpha-2 agonists in anesthesia Maze M Advances in anesthesia . Jan 1, 1990 Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. Weinger MB, Segal IS, Maze M Anesthesiology . Aug 1, 1989 Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Doze VA, Chen BX, Maze M Anesthesiology . Jul 1, 1989 Action of the stereoisomers of medetomidine, in halothane-anesthetized dogs. Vickery RG, Maze M Acta veterinaria Scandinavica. Supplementum . Jan 1, 1989 Anesthesia and ion channel function in the autonomic nervous system. Maze M International anesthesiology clinics . Jan 1, 1989 Dexmedetomidine decreases halothane anesthetic requirements in rats. Segal IS, Vickery RG, Maze M Acta veterinaria Scandinavica. Supplementum . Jan 1, 1989 Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Doze V, Chen BX, Li Z, Maze M Acta veterinaria Scandinavica. Supplementum . Jan 1, 1989 Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Segal IS, Vickery RG, Walton JK, Doze VA, Maze M Anesthesiology . Dec 1, 1988 Anesthetic and hemodynamic effects of the stereoisomers of medetomidine, an alpha 2-adrenergic agonist, in halothane-anesthetized dogs. Vickery RG, Sheridan BC, Segal IS, Maze M Anesthesia and analgesia . Jul 1, 1988 Mechanism for desensitization of beta-adrenergic receptor-stimulated lipolysis in adipocytes from rats harboring pheochromocytoma. Prokocimer PG, Maze M, Vickery RG, Hoffman BB Endocrinology . Jul 1, 1988 Anesthetic and hemodynamic effects of the alpha 2-adrenergic agonist, azepexole, in isoflurane-anesthetized dogs. Maze M, Vickery RG, Merlone SC, Gaba DM Anesthesiology . May 1, 1988 Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes. Prokocimer PG, Maze M, Vickery RG, Kraemer FB, Gandjei R, Hoffman BB Molecular pharmacology . Mar 1, 1988 Clonidine and other alpha2 adrenergic agonists: strategies for the rational use of these novel anesthetic agents. Maze M, Segal IS, Bloor BC Journal of clinical anesthesia . Jan 1, 1988 L-phenylisopropyladenosine (L-PIA) diminishes halothane anesthetic requirements and decreases noradrenergic neurotransmission in rats. Birch BD, Louie GL, Vickery RG, Gaba DM, Maze M Life sciences . Jan 1, 1988 Perioperative changes in adrenergic responsiveness: Effects of anesthetics on adrenoceptor effector mechanisms Maze M, Prokocimer PG, Marty JM, Syrota A, Seto M, Kraemer FB, Hoffman BB Neurology and Neurobiology . Jan 1, 1988 Clonidine reduces halothane MAC in rats. Maze M, Birch B, Vickery RG Anesthesiology . Nov 1, 1987 Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. Prokocimer PG, Maze M, Hoffman BB The Journal of pharmacology and experimental therapeutics . Jun 1, 1987 Halothane hepatotoxicity in Fischer 344 rats pretreated with isoniazid. Rice SA, Maze M, Smith CM, Kosek JC, Mazze RI Toxicology and applied pharmacology . Mar 15, 1987 Pulmonary and systemic hemodynamic effects of central venous and left atrial sympathomimetic drug administration in the dog. Pearl RG, Maze M, Rosenthal MH Journal of cardiothoracic anesthesia . Feb 1, 1987 Halothane anesthetic requirements are not affected by aminophylline treatment in rats and dogs. Nicholls EA, Louie GL, Prokocimer PG, Maze M Anesthesiology . Dec 1, 1986 Aminophylline shortens thiopental sleep-time and enhances noradrenergic neurotransmission in rats. Louie GL, Prokocimer PG, Nicholls EA, Maze M Brain research . Sep 24, 1986 Epinephrine arrhythmogenicity is enhanced by acute, but not chronic, aminophylline administration during halothane anesthesia in dogs. Prokocimer PG, Nicholls E, Gaba DM, Maze M Anesthesiology . Jul 1, 1986 Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion. Maze M, Hayward E, Gaba DM Anesthesiology . Dec 1, 1985 Effects of volatile anesthetics or fentanyl on hepatic function in cirrhotic rats. Baden JM, Kundomal YR, Luttropp ME, Maze M, Kosek JC Anesthesia and analgesia . Dec 1, 1985 Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle. Maze M, Spiss CK, Tsujimoto G, Hoffman BB Life sciences . Oct 28, 1985 Antiarrhythmic effect of verapamil may be independent of calcium channel blockade. Metz S, Maze M Anesthesiology . Aug 1, 1985 A multicenter study of the epidemiology of hepatitis B in anesthesia residents. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Clark BT, Beaupre P, Derrer S, Kapur P, Thompson J, Martin D Anesthesia and analgesia . Jul 1, 1985 Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs. Gaba DM, Metz S, Maze M Anesthesiology . May 1, 1985 Halothane concentration does not alter the threshold for epinephrine-induced arrhythmias in dogs. Metz S, Maze M Anesthesiology . Apr 1, 1985 Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats. Maze M, Smith CM, Baden JM Anesthesiology . Jan 1, 1985 Prolonged hyporesponsiveness of vascular smooth muscle contraction after halothane anesthesia in rabbits. Spiss CK, Smith CM, Tsujimoto G, Hoffman BB, Maze M Anesthesia and analgesia . Jan 1, 1985 [Adrenoreceptors]. Spiss CK, Maze M Der Anaesthesist . Jan 1, 1985 Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs. Spiss CK, Smith CM, Maze M Anesthesia and analgesia . Sep 1, 1984 A multicenter study of the prevalence of hepatitis B viral serologic markers in anesthesia personnel. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Bastron RD, Maze M, Spiss CK, Rizk SF, Ronai AK, Kimovec MA Anesthesia and analgesia . Aug 1, 1984 Alpha-adrenergic responsiveness correlates with epinephrine dose for arrhythmias during halothane anesthesia in dogs. Spiss CK, Maze M, Smith CM Anesthesia and analgesia . Mar 1, 1984 Identification of receptor mechanism mediating epinephrine-induced arrhythmias during halothane anesthesia in the dog. Maze M, Smith CM Anesthesiology . Oct 1, 1983 Verapamil decreases MAC for halothane in dogs. Maze M, Mason DM, Kates RE Anesthesiology . Oct 1, 1983 Etiology and treatment of halothane-induced arrhythmias Maze M, Mason DM Clinics in Anaesthesiology . Aug 12, 1983 Prednisolone enhances aminopeptidase turnover in adult rat small intestine. Scott J, Maze M, Peters TJ Biochimica et biophysica acta . Dec 17, 1982 Clinical implications of membrane receptor function in anesthesia. Maze M Anesthesiology . Aug 1, 1981 Intestinal brush border aminooligopeptidases: cytosol precursors of the membrane enzyme. Maze M, Gray GM Biochemistry . May 27, 1980 Beta-receptor blockade following the use of eye drops. Samuels SI, Maze M Anesthesiology . Apr 1, 1980 Clinical trial of four pancreatic scanning agents. Agnew JE, Maze M The British journal of radiology . Mar 1, 1978 Pancreatic scanning. Agnew JE, Maze M, Mitchell CJ The British journal of radiology . Dec 1, 1976 Letter: Uptake of 67Ga in space-occupying lesions in the liver. Maze M, Wood J Journal of nuclear medicine : official publication, Society of Nuclear Medicine . May 1, 1975 Proceedings: 67Ga citrate liver scanning: evaluation of its use in 80 patients and evidence of intrahepatic distribution by autoradiography. James O, Wood J, Maze M, Gayotto LC, Williams HS, Sherlock S Gut . Apr 1, 1974 Involuntary muscle involvement in dystrophia myotonica. Case report. Maze M, Novis BH, Lurie BB, Bank S South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde . Oct 20, 1973
