Biography I was born in South Africa and obtained my medical degree with honors from the University of Cape Town in 1070. I emigrated from apartheid-era South Africa after my junior doctor training at Groote Schuur Hospital, Cape Town, and subsequently trained in internal medicine at the Royal Free Hospital, London England. I continued my training as a postdoctoral research fellow at Stanford University where I completed my residency in anesthesia in 1981. After joining the faculty in the Department of Anesthesia at Stanford, I received successive promotions to become a tenured professor and Vice-Chair for Research. In 1999, I was recruited to become the Magill Professor of Anaesthesia at Imperial College, London and subsequently became the Chair of Surgery, Oncology, Reproductive Biology and Anesthesia at Imperial College. In 2009, I was recruited to become the Chair of Anesthesia and Perioperative Care at UCSF which I held for 5 years before transitioning to full-time research at the Zuckerberg San Francisco General, the county-hospital campus for UCSF. My career in sponsored research began under the tutelage of Dame Sheila Sherlock in 1974 and has been a major focus of my academic activities for more than 50 years. During that time, I have been funded and led laboratories at Stanford, Imperial College, and UCSF. I have published more than 300 peer-reviewed publications and received several national and international awards for my research. According to Google Scholar (accessed 7-29-25), my h-index is 104 and I have over 42,000 citations. I have been married to Janet Wyner MD for 56 years and have two children (Brad and Jacqui) and 6 grand-children. Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Education Residency, 1981 - Anesthesia, Stanford University, Department of AnesthesiaPostdoctoral Research Fellow, 1979 - Medicine, Stanford University, Department of MedicineRegistrar, 1976 - Medicine, Royal Free HospitalInternship, Resident Medical Officer, 1972 - Medicine, Groote Schuur Hospital, Cape Town, S. AfricaMB,ChB, 1970 - Bachelor of Medicine (Honors) Bachelor of Surgery (Honors), University of Cape Town, South Africa Publications Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration. Leng K, Maze M, Barreto Chang OL Alpha-2 adrenergic agonists in Anesthesiology Buttermann AE, Maze M A comparison of large language model-generated and published perioperative neurocognitive disorder recommendations: a cross-sectional web-based analysis. Saxena S, Barreto Chang OL, Suppan M, Meco BC, Vacas S, Radtke F, Matot I, Devos A, Maze M, Gisselbaek M, Berger-Estilita J Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized Non-inferiority trial. Fang PP, Hu J, Wei QF, Liang YJ, Fan YG, Shen QY, Lu Y, Liu XS, Maze M, REMPPOD study collaborators Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial. Hollmén C, Parkkola R, Vorobyev V, Saunavaara J, Laitio R, Arola O, Hynninen M, Bäcklund M, Martola J, Ylikoski E, Roine RO, Tiainen M, Scheinin H, Maze M, Vahlberg T, Laitio TT The role of cultural competency training to address health disparities in surgical settings. Mora R, Maze M ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings. Langnas E, Maze M Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy. DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies. Barreto Chang OL, Maze M Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial. Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT, XeHYPOTHECA Research Group Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets. Barreto Chang OL, Possin KL, Maze M Considerations for the implementation of machine learning into acute care settings. Bishara A, Maze EH, Maze M Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia. Hu J, Zhang Y, Maze M Early postoperative risk prediction of neurocognitive decline. Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders. Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial. Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders. Saxena S, Kruys V, Vamecq J, Maze M Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study. Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award. Pearce RA, Maze M Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Li R, Lai IK, Pan JZ, Zhang P, Maze M Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M Perioperative Neurocognitive Disorder: State of the Preclinical Science. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF Neuroprotective Properties of Xenon. Maze M, Laitio T Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. Rylova A, Maze M Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders? Li R, Lai IK, Maze M Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group Diagnostic accuracy of leptospirosis whole-cell lateral flow assays: a systematic review and meta-analysis. Maze MJ, Sharples KJ, Allan KJ, Rubach MP, Crump JA Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M Restoring Order to Postoperative Neurocognitive Disorders. Saxena S, Uchida Y, Maze M Impact on the brain of the inflammatory response to surgery. Saxena S, Maze M Past, present, and future of nitrous oxide. Lew V, McKay E, Maze M Methods for Defining the Neuroprotective Properties of Xenon. Robel R, Caroccio P, Maze M The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Maze MJ, Bassat Q, Feasey NA, Mandomando I, Musicha P, Crump JA Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M Perioperative management of the obese surgical patient. Lang LH, Parekh K, Tsui BYK, Maze M Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T, Xe-HYPOTHECA Study Group The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. Coburn M, Sanders RD, Maze M, Nguyên-Pascal ML, Rex S, Garrigues B, Carbonell JA, Garcia-Perez ML, Stevanovic A, Kienbaum P, Neukirchen M, Schaefer MS, Borghi B, van Oven H, Tognù A, Al Tmimi L, Eyrolle L, Langeron O, Capdevila X, Arnold GM, Schaller M, Rossaint R, HIPELD Study Investigators In Response. Vacas S, Maze M The immune response of the human brain to abdominal surgery. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction. Vacas S, Degos V, Maze M Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1. Vacas S, Maze M "A Time of Opportunity": Patient Safety and the Perioperative Surgical Home. Garson LM, Vakharia S, Edwards AF, Maze M From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Maze M Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand. Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C Correction: Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings? Maze M, Pirracchio R Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review. Maze M Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. Feng X, Maze M, Koch LG, Britton SL, Hellman J Preoperative medical testing in Medicare patients undergoing cataract surgery. Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M In reply. Vacas S, Degos V, Maze M Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. Han Z, Li L, Wang L, Degos V, Maze M, Su H Endoglin deficiency impairs stroke recovery. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Vacas S, Degos V, Tracey KJ, Maze M Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Bozic KJ, Ward L, Vail TP, Maze M Take off, landing, and fly anesthesia. Sanders RD, Maze M Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T Bone fracture exacerbates murine ischemic cerebral injury. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M The neuroinflammatory response of postoperative cognitive decline. Vacas S, Degos V, Feng X, Maze M G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M Sleep and Anesthesia - Common mechanisms of action. Vacas S, Kurien P, Maze M Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS Noradrenergic trespass in anesthetic and sedative states. Sanders RD, Maze M The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery. Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation. Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M Reprogramming of the infant brain by surgery with general anesthesia. Culley DJ, Maze M, Crosby G Resolving postoperative neuroinflammation and cognitive decline. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M Sedation & immunomodulation. Sanders RD, Hussell T, Maze M N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation. Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D Perioperative cognitive decline in the aging population. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF, Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop Anticipating and managing postoperative delirium and cognitive decline in adults. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG A clinically relevant model of perinatal global ischemic brain damage in rats. Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D Nucleic Acid Amplification of the opa Gene for Detection of Neisseria gonorrhoeae: experience from a diagnostic laboratory. Maze MJ, Young S, Creighton J, Anderson T, Werno A Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Sanders RD, Maze M Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M Role of interleukin-1beta in postoperative cognitive dysfunction. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Cattano D, Valleggi S, Abramo A, Forfori F, Maze M, Giunta F Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Bantel C, Maze M, Trapp S Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I Argon neuroprotection. Sanders RD, Ma D, Maze M Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic? Sanders RD, Maze M Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion. Limatola V, Ward P, Cattano D, Gu J, Giunta F, Maze M, Ma D Does correcting the numbers improve long-term outcome? Sanders RD, Maze M Sedation improves early outcome in severely septic Sprague Dawley rats. Qiao H, Sanders RD, Ma D, Wu X, Maze M Sedation & immunomodulation. Sanders RD, Hussell T, Maze M Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Bantel C, Maze M, Trapp S The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Sanders RD, Weimann J, Maze M Xenon up-regulates several genes that are not up-regulated by nitrous oxide. Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity. Sanders RD, Ma D, Brooks P, Maze M Expecting the unexpected. Talke PO, Maze M General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M Role of endogenous sleep-wake and analgesic systems in anesthesia. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB Xenon induces transcription of ADNP in neonatal rat brain. Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Coburn M, Maze M, Franks NP Taking the lead in research into postoperative cognitive dysfunction. Maze M, Cibelli M, Grocott HP Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP Translational research: addressing problems facing the anesthesiologist. Sanders RD, Maze M Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Newman S, Stygall J, Hirani S, Shaefi S, Maze M Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium. Maze M, Todd MM Adrenergic and cholinergic compounds. Sanders RD, Maze M Alpha2-adrenoceptor agonists. Sanders RD, Maze M The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Preckel B, Weber NC, Sanders RD, Maze M, Schlack W The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat. Nekhendzy V, Davies MF, Lemmens HJ, Maze M A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M Expansion of gas bubbles by nitrous oxide and xenon. Benavides R, Maze M, Franks NP Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit? Pandharipande P, Ely EW, Maze M Anaesthesia induced neuroprotection. Sanders RD, Ma D, Maze M Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M Xenon and the inflammatory response to cardiopulmonary bypass in the rat. Clark JA, Ma D, Homi HM, Maze M, Grocott HP Xenon: from stranger to guardian. Sanders RD, Maze M Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats. Sanders RD, Patel N, Hossain M, Ma D, Maze M Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M Xenon: elemental anaesthesia in clinical practice. Sanders RD, Ma D, Maze M alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Ma D, Rajakumaraswamy N, Maze M Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Maze M, Angst MS Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Angst MS, Ramaswamy B, Davies MF, Maze M Dexmedetomidine: another arrow for the clinician's quiver. Ebert T, Maze M Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Nelson LE, Franks NP, Maze M Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Coull JT, Jones ME, Egan TD, Frith CD, Maze M Xenon exerts age-independent antinociception in Fischer rats. Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Dawson C, Ma D, Chow A, Maze M The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M Xenon: no stranger to anaesthesia. Sanders RD, Franks NP, Maze M Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats. Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats. Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M Evaluation of high fidelity patient simulator in assessment of performance of anaesthetists. Weller JM, Bloch M, Young S, Maze M, Oyesola S, Wyner J, Dob D, Haire K, Durbridge J, Walker T, Newble D Evidence for the involvement of spinal cord alpha1 adrenoceptors in nitrous oxide-induced antinociceptive effects in Fischer rats. Orii R, Ohashi Y, Guo T, Nelson LE, Hashimoto T, Maze M, Fujinaga M Neuroprotective and neurotoxic properties of the 'inert' gas, xenon. Ma D, Wilhelm S, Maze M, Franks NP Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats. Ohashi Y, Stowell JM, Nelson LE, Hashimoto T, Maze M, Fujinaga M The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M Effects of xenon on in vitro and in vivo models of neuronal injury. Wilhelm S, Ma D, Maze M, Franks NP Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M Neurobiology of nitrous oxide-induced antinociceptive effects. Fujinaga M, Maze M Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats. Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord. Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M Fetuses, fentanyl, and the stress response: signals from the beginnings of pain? Anand KJ, Maze M New agents for sedation in the intensive care unit. Maze M, Scarfini C, Cavaliere F Glucocorticoid inhibition of neuropathic limb edema and cutaneous neurogenic extravasation. Kingery WS, Guo T, Agashe GS, Davies MF, Clark JD, Maze M Pharmacology of nitrous oxide Maze M, Fujinaga M Nitrous oxide activates GABAergic neurons in the spinal cord in Fischer rats. Hashimoto T, Maze M, Ohashi Y, Fujinaga M Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors. Davies MF, Reid K, Guo TZ, Agashe GS, Amin YK, Maze M Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression. Kingery WS, Agashe GS, Sawamura S, Davies MF, Clark JD, Maze M Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M Controversial issues in adult and paediatric ambulatory anaesthesia: is there a role for alpha-2 agonists in conscious sedation in adults and paediatric ambulatory surgical practice? Wilhelm S, Maze M Clinical uses of alpha2 -adrenergic agonists. Kamibayashi T, Maze M Nitrous oxide lacks the antinociceptive effect on the tail flick test in newborn rats. Fujinaga M, Doone R, Davies MF, Maze M Alpha2 adrenoceptors in pain modulation: which subtype should be targeted to produce analgesia? Maze M, Fujinaga M Recent advances in understanding the actions and toxicity of nitrous oxide. Maze M, Fujinaga M The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M Dexmedetomidine: Viewpoints Maze M, Talke P, Hassan E Strain differences in the antinociceptive effect of nitrous oxide on the tail flick test in rats. Fender C, Fujinaga M, Maze M The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Zhang C, Davies MF, Guo TZ, Maze M Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Kingery WS, Castellote JM, Maze M Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M Are cholinergic pathways involved in the anesthetic response to alpha2 agonists. Buttermann AE, Reid K, Maze M The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors. Poree LR, Guo TZ, Kingery WS, Maze M Chronic desipramine treatment desensitizes the rat to anesthetic and antinociceptive effects of the alpha2-adrenergic agonist dexmedetomidine. Guo TZ, Reid K, Davies MF, Nacif-Coelho C, Rabin BC, Gonzalez F, Maze M Colchicine treatment of the sciatic nerve reduces neurogenic extravasation, but does not affect nociceptive thresholds or collateral sprouting in neuropathic or normal rats. Kingery WS, Guo TZ, Poree LR, Maze M In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE Nifedipine, an L-type calcium channel blocker, restores the hypnotic response in rats made tolerant to the alpha-2 adrenergic agonist dexmedetomidine. Reid K, Guo TZ, Davies MF, Maze M "Exciting" aspects of opiate receptor signal transduction. Maze M Why does insensitivity to opioid narcotics develop? Maze M Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats. Fang F, Guo TZ, Davies MF, Maze M Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE Alpha-2 adrenergic agonists. Kamibayashi T, Harasawa K, Maze M Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. Reid K, Hayashi Y, Hsu J, Maguire PA, Rabin BC, Guo TZ, Maze M Dissociation of hypnotic-anesthetic actions of alpha 2 agonists from cyclic AMP in the rat. Rabin BC, Guo TZ, Maze M Molecular Pharmacology of alpha-2 adrenoceptors; relevance to anesthesia Mizobe T; Maze M Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat. Guo TZ, Poree L, Golden W, Stein J, Fujinaga M, Maze M Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats. Hayashi Y, Guo TZ, Maze M Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. Rabin BC, Reid K, Guo TZ, Gustafsson E, Zhang C, Maze M Perioperative use of alpha-2 adrenergic agonists Kamibayashi T, Maze M Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit. Kim HK, Zornow MH, Strnat MA, Maze M Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Rabin BC, Guo TZ, Gregg K, Maze M Dexmedetomidine injection into the locus ceruleus produces antinociception. Guo TZ, Jiang JY, Buttermann AE, Maze M Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin. Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. Seidel WF, Maze M, Dement WC, Edgar DM Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. Hayashi Y, Rabin BC, Guo TZ, Maze M Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Hayashi Y, Guo TZ, Maze M Alpha 2-adrenoceptor agonists and anesthesia. Mizobe T, Maze M Anaesthetic and analgesic action of alpha-2 adrenoceptor agonists Maze M, Poree L, Rabin BC Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Nacif-Coelho C, Correa-Sales C, Chang LL, Maze M Chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Reid K, Hayashi Y, Guo TZ, Correa-Sales C, Nacif-Coelho C, Maze M Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses. Daunt DA, Dunlop CI, Chapman PL, Shafer SL, Ruskoaho H, Vakkuri O, Hodgson DS, Tyler LM, Maze M The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Matsumoto M, Zornow MH, Rabin BC, Maze M Implementation of a radioreceptor assay for dexmedetomidine. Salonen M, Maze M Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Maier C, Steinberg GK, Sun GH, Zhi GT, Maze M Alpha 2 adrenoceptor agonists and anaesthesia. Hayashi Y, Maze M Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Dyck JB, Maze M, Haack C, Azarnoff DL, Vuorilehto L, Shafer SL The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL Dexmedetomidine decreases cerebral blood flow velocity in humans. Zornow MH, Maze M, Dyck JB, Shafer SL Role of imidazoline-preferring receptors in the genesis of epinephrine-induced arrhythmias in halothane-anesthetized dogs. Hayashi Y, Kamibayashi T, Maze M, Yamatodani A, Sumikawa K, Kuro M, Yoshiya I Molecular Pharmacology of alpha-2 adrenergic receptors Maze M, Scheinin M Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Belleville JP, Ward DS, Bloor BC, Maze M Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Bloor BC, Ward DS, Belleville JP, Maze M Pertussis toxin-mediated ribosylation of G proteins blocks the hypnotic response to an alpha 2-agonist in the locus coeruleus of the rat. Correa-Sales C, Reid K, Maze M A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Correa-Sales C, Rabin BC, Maze M Synergistic interaction between alpha 2-adrenergic agonists and benzodiazepines in rats. Salonen M, Reid K, Maze M Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers. Jarvis DA, Duncan SR, Segal IS, Maze M Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Fujinaga M, Maze M, Hoffman BB, Baden JM Clinical interactions with alpha-2-adrenergic agonists in anesthetic practice. Salonen MA, Kanto JH, Maze M Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats. Salonen M, Onaivi ES, Maze M A comparison of etomidate and thiopental anesthesia for cardioversion. Ford SR, Maze M, Gaba DM Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: in vivo and in vitro studies. Schwinn DA, Correa-Sales C, Page SO, Maze M Mechanism of antiarrhythmic effect of dexmedetomidine on epinephrine-induced arrhythmias (Correspondence; Peer-Reviewed) Hayashi Y, Sumikawa K, Maze M Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Savola MK, Woodley SJ, Maze M, Kendig JJ Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Guo TZ, Tinklenberg J, Oliker R, Maze M Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Maze M, Virtanen R, Daunt D, Banks SJ, Stover EP, Feldman D Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Hayashi Y, Sumikawa K, Maze M, Yamatodani A, Kamibayashi T, Kuro M, Yoshiya I Attenuation of central alpha 2 adrenergic action in diabetic rats. Guo TZ, Maze B, Maze M The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Savola MK, MacIver MB, Doze VA, Kendig JJ, Maze M Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Maze M, Tranquilli W Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period. Segal IS, Jarvis DJ, Duncan SR, White PF, Maze M Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. Kendig JJ, Savola MK, Woodley SJ, Maze M Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila. Tinklenberg JA, Segal IS, Guo TZ, Maze M Role of signal transduction in anesthetic action. Alpha 2 adrenergic agonists. Maze M, Regan JW Modulating role of dopamine on anesthetic requirements. Segal IS, Walton JK, Irwin I, DeLanney LE, Ricaurte GA, Langston JW, Maze M Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital. Doze VA, Chen BX, Tinklenberg JA, Segal IS, Maze M Transmembrane signalling and the holy grail of anesthesia. Maze M Adrenergic characteristics of the pulmonary artery "barorefelex" De Campli WM, Baldwin JC, Hagberg RC, Gaba DM, Maze M The role of alpha-2 agonists in anesthesia Maze M Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. Weinger MB, Segal IS, Maze M Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Doze VA, Chen BX, Maze M Action of the stereoisomers of medetomidine, in halothane-anesthetized dogs. Vickery RG, Maze M Anesthesia and ion channel function in the autonomic nervous system. Maze M Dexmedetomidine decreases halothane anesthetic requirements in rats. Segal IS, Vickery RG, Maze M Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Doze V, Chen BX, Li Z, Maze M Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Segal IS, Vickery RG, Walton JK, Doze VA, Maze M Anesthetic and hemodynamic effects of the stereoisomers of medetomidine, an alpha 2-adrenergic agonist, in halothane-anesthetized dogs. Vickery RG, Sheridan BC, Segal IS, Maze M Mechanism for desensitization of beta-adrenergic receptor-stimulated lipolysis in adipocytes from rats harboring pheochromocytoma. Prokocimer PG, Maze M, Vickery RG, Hoffman BB Anesthetic and hemodynamic effects of the alpha 2-adrenergic agonist, azepexole, in isoflurane-anesthetized dogs. Maze M, Vickery RG, Merlone SC, Gaba DM Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes. Prokocimer PG, Maze M, Vickery RG, Kraemer FB, Gandjei R, Hoffman BB Clonidine and other alpha2 adrenergic agonists: strategies for the rational use of these novel anesthetic agents. Maze M, Segal IS, Bloor BC L-phenylisopropyladenosine (L-PIA) diminishes halothane anesthetic requirements and decreases noradrenergic neurotransmission in rats. Birch BD, Louie GL, Vickery RG, Gaba DM, Maze M Perioperative changes in adrenergic responsiveness: Effects of anesthetics on adrenoceptor effector mechanisms Maze M, Prokocimer PG, Marty JM, Syrota A, Seto M, Kraemer FB, Hoffman BB Clonidine reduces halothane MAC in rats. Maze M, Birch B, Vickery RG Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. Prokocimer PG, Maze M, Hoffman BB Halothane hepatotoxicity in Fischer 344 rats pretreated with isoniazid. Rice SA, Maze M, Smith CM, Kosek JC, Mazze RI Pulmonary and systemic hemodynamic effects of central venous and left atrial sympathomimetic drug administration in the dog. Pearl RG, Maze M, Rosenthal MH Halothane anesthetic requirements are not affected by aminophylline treatment in rats and dogs. Nicholls EA, Louie GL, Prokocimer PG, Maze M Aminophylline shortens thiopental sleep-time and enhances noradrenergic neurotransmission in rats. Louie GL, Prokocimer PG, Nicholls EA, Maze M Epinephrine arrhythmogenicity is enhanced by acute, but not chronic, aminophylline administration during halothane anesthesia in dogs. Prokocimer PG, Nicholls E, Gaba DM, Maze M Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion. Maze M, Hayward E, Gaba DM Effects of volatile anesthetics or fentanyl on hepatic function in cirrhotic rats. Baden JM, Kundomal YR, Luttropp ME, Maze M, Kosek JC Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle. Maze M, Spiss CK, Tsujimoto G, Hoffman BB Antiarrhythmic effect of verapamil may be independent of calcium channel blockade. Metz S, Maze M A multicenter study of the epidemiology of hepatitis B in anesthesia residents. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Clark BT, Beaupre P, Derrer S, Kapur P, Thompson J, Martin D Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs. Gaba DM, Metz S, Maze M Halothane concentration does not alter the threshold for epinephrine-induced arrhythmias in dogs. Metz S, Maze M Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats. Maze M, Smith CM, Baden JM Prolonged hyporesponsiveness of vascular smooth muscle contraction after halothane anesthesia in rabbits. Spiss CK, Smith CM, Tsujimoto G, Hoffman BB, Maze M [Adrenoreceptors]. Spiss CK, Maze M Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs. Spiss CK, Smith CM, Maze M A multicenter study of the prevalence of hepatitis B viral serologic markers in anesthesia personnel. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Bastron RD, Maze M, Spiss CK, Rizk SF, Ronai AK, Kimovec MA Alpha-adrenergic responsiveness correlates with epinephrine dose for arrhythmias during halothane anesthesia in dogs. Spiss CK, Maze M, Smith CM Identification of receptor mechanism mediating epinephrine-induced arrhythmias during halothane anesthesia in the dog. Maze M, Smith CM Verapamil decreases MAC for halothane in dogs. Maze M, Mason DM, Kates RE Etiology and treatment of halothane-induced arrhythmias Maze M, Mason DM Prednisolone enhances aminopeptidase turnover in adult rat small intestine. Scott J, Maze M, Peters TJ Clinical implications of membrane receptor function in anesthesia. Maze M Intestinal brush border aminooligopeptidases: cytosol precursors of the membrane enzyme. Maze M, Gray GM Beta-receptor blockade following the use of eye drops. Samuels SI, Maze M Clinical trial of four pancreatic scanning agents. Agnew JE, Maze M Pancreatic scanning. Agnew JE, Maze M, Mitchell CJ Letter: Uptake of 67Ga in space-occupying lesions in the liver. Maze M, Wood J Proceedings: 67Ga citrate liver scanning: evaluation of its use in 80 patients and evidence of intrahepatic distribution by autoradiography. James O, Wood J, Maze M, Gayotto LC, Williams HS, Sherlock S Involuntary muscle involvement in dystrophia myotonica. Case report. Maze M, Novis BH, Lurie BB, Bank S
