Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Publications Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized Non-inferiority trial. Fang PP, Hu J, Wei QF, Liang YJ, Fan YG, Shen QY, Lu Y, Liu XS, Maze M, REMPPOD study collaborators Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial. Hollmén C, Parkkola R, Vorobyev V, Saunavaara J, Laitio R, Arola O, Hynninen M, Bäcklund M, Martola J, Ylikoski E, Roine RO, Tiainen M, Scheinin H, Maze M, Vahlberg T, Laitio TT The role of cultural competency training to address health disparities in surgical settings. Mora R, Maze M ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings. Langnas E, Maze M Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy. DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies. Barreto Chang OL, Maze M Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial. Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT, XeHYPOTHECA Research Group Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets. Barreto Chang OL, Possin KL, Maze M Considerations for the implementation of machine learning into acute care settings. Bishara A, Maze EH, Maze M Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia. Hu J, Zhang Y, Maze M Early postoperative risk prediction of neurocognitive decline. Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders. Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial. Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders. Saxena S, Kruys V, Vamecq J, Maze M Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study. Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award. Pearce RA, Maze M Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Li R, Lai IK, Pan JZ, Zhang P, Maze M Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M Perioperative Neurocognitive Disorder: State of the Preclinical Science. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF Neuroprotective Properties of Xenon. Maze M, Laitio T Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. Rylova A, Maze M Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders? Li R, Lai IK, Maze M Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M Restoring Order to Postoperative Neurocognitive Disorders. Saxena S, Uchida Y, Maze M Impact on the brain of the inflammatory response to surgery. Saxena S, Maze M Past, present, and future of nitrous oxide. Lew V, McKay E, Maze M Methods for Defining the Neuroprotective Properties of Xenon. Robel R, Caroccio P, Maze M Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M Perioperative management of the obese surgical patient. Lang LH, Parekh K, Tsui BYK, Maze M Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T, Xe-HYPOTHECA Study Group In Response. Vacas S, Maze M The immune response of the human brain to abdominal surgery. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction. Vacas S, Degos V, Maze M Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1. Vacas S, Maze M "A Time of Opportunity": Patient Safety and the Perioperative Surgical Home. Garson LM, Vakharia S, Edwards AF, Maze M From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Maze M Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand. Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings? Maze M, Pirracchio R Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review. Maze M Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. Feng X, Maze M, Koch LG, Britton SL, Hellman J Preoperative medical testing in Medicare patients undergoing cataract surgery. Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M In reply. Vacas S, Degos V, Maze M Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. Han Z, Li L, Wang L, Degos V, Maze M, Su H Endoglin deficiency impairs stroke recovery. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Vacas S, Degos V, Tracey KJ, Maze M Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Bozic KJ, Ward L, Vail TP, Maze M Take off, landing, and fly anesthesia. Sanders RD, Maze M Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T Bone fracture exacerbates murine ischemic cerebral injury. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M The neuroinflammatory response of postoperative cognitive decline. Vacas S, Degos V, Feng X, Maze M G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M Sleep and Anesthesia - Common mechanisms of action. Vacas S, Kurien P, Maze M Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS Noradrenergic trespass in anesthetic and sedative states. Sanders RD, Maze M The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery. Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation. Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M Reprogramming of the infant brain by surgery with general anesthesia. Culley DJ, Maze M, Crosby G Resolving postoperative neuroinflammation and cognitive decline. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation. Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D Perioperative cognitive decline in the aging population. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF, Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop Anticipating and managing postoperative delirium and cognitive decline in adults. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG A clinically relevant model of perinatal global ischemic brain damage in rats. Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Sanders RD, Maze M Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M Role of interleukin-1beta in postoperative cognitive dysfunction. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Bantel C, Maze M, Trapp S Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I Argon neuroprotection. Sanders RD, Ma D, Maze M Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic? Sanders RD, Maze M Does correcting the numbers improve long-term outcome? Sanders RD, Maze M Sedation improves early outcome in severely septic Sprague Dawley rats. Qiao H, Sanders RD, Ma D, Wu X, Maze M Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Bantel C, Maze M, Trapp S Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Sanders RD, Weimann J, Maze M Xenon up-regulates several genes that are not up-regulated by nitrous oxide. Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F Expecting the unexpected. Talke PO, Maze M General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M Role of endogenous sleep-wake and analgesic systems in anesthesia. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB Xenon induces transcription of ADNP in neonatal rat brain. Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Coburn M, Maze M, Franks NP Taking the lead in research into postoperative cognitive dysfunction. Maze M, Cibelli M, Grocott HP Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP Translational research: addressing problems facing the anesthesiologist. Sanders RD, Maze M Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Newman S, Stygall J, Hirani S, Shaefi S, Maze M Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium. Maze M, Todd MM Alpha2-adrenoceptor agonists. Sanders RD, Maze M The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Preckel B, Weber NC, Sanders RD, Maze M, Schlack W The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat. Nekhendzy V, Davies MF, Lemmens HJ, Maze M A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M Expansion of gas bubbles by nitrous oxide and xenon. Benavides R, Maze M, Franks NP Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M Anaesthesia induced neuroprotection. Sanders RD, Ma D, Maze M Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M Xenon and the inflammatory response to cardiopulmonary bypass in the rat. Clark JA, Ma D, Homi HM, Maze M, Grocott HP Xenon: from stranger to guardian. Sanders RD, Maze M Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M Xenon: elemental anaesthesia in clinical practice. Sanders RD, Ma D, Maze M alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Ma D, Rajakumaraswamy N, Maze M Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Maze M, Angst MS Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Angst MS, Ramaswamy B, Davies MF, Maze M Dexmedetomidine: another arrow for the clinician's quiver. Ebert T, Maze M Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Nelson LE, Franks NP, Maze M Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Coull JT, Jones ME, Egan TD, Frith CD, Maze M Xenon exerts age-independent antinociception in Fischer rats. Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Dawson C, Ma D, Chow A, Maze M The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats. Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats. Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M Evidence for the involvement of spinal cord alpha1 adrenoceptors in nitrous oxide-induced antinociceptive effects in Fischer rats. Orii R, Ohashi Y, Guo T, Nelson LE, Hashimoto T, Maze M, Fujinaga M Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats. Ohashi Y, Stowell JM, Nelson LE, Hashimoto T, Maze M, Fujinaga M Effects of xenon on in vitro and in vivo models of neuronal injury. Wilhelm S, Ma D, Maze M, Franks NP Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M Neurobiology of nitrous oxide-induced antinociceptive effects. Fujinaga M, Maze M Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats. Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord. Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Kingery WS, Castellote JM, Maze M
