Merlin Larson, MD

Professor Emeritus
Larson MD. Commentary on pupillometry and pain ratings. Eur J Pain. 2023 09; 27(8):925-926.
Jakobsen EW, Nersesjan V, Albrechtsen SS, Othman MH, Amiri M, Knudsen NV, Larson MD, Hassager C, Møller K, Kjaergaard J, Kondziella D. Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury. Acta Neurochir (Wien). 2023 06; 165(6):1483-1494.
Larson MD. Reader Response: Automated Quantitative Pupillometry in the Critically Ill: A Systematic Review of the Literature. Neurology. 2021 12 14; 97(24):1140.
Marco-Ariño N, Vide S, Agustí M, Chen A, Jaramillo S, Irurzun-Arana I, Pacheco A, Gonzalez C, Jensen EW, Capsi-Morales P, Valencia JF, Troconiz IF, Gambus PL, Larson MD. Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids. CPT Pharmacometrics Syst Pharmacol. 2022 05; 11(5):581-593.
McKay, Rachel Eshima Larson, Merlin D.. Detection of Opioid Effect with Pupillometry. Autonomic Neuroscience. 2021; 235.
Elyn, A Saffon, N Larson, M. Monitoring the Depth of Palliative Sedation by Video-Pupillometry: A Case Report. Palliative Medicine. 2021.
Larson, M. Reader Response: Automated Quantitative Pupillometry in the Critically Ill. Neurology. 2021.
McKay RE, Kohn MA, Larson MD. Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression. J Clin Monit Comput. 2022 04; 36(2):473-482.
McKay RE, Kohn MA, Schwartz ES, Larson MD. Evaluation of two portable pupillometers to assess clinical utility. Concussion. 2020 Oct 28; 5(4):CNC82.
Larson M, Neice A. Nociceptive monitor subtypes. Comment on 'Objective monitoring of nociception: a review of current commercial solutions' (Br J Anaesth 2019; 123:e312-e321). Br J Anaesth. 2019 10; 123(4):e485-e486.
Vide S, Castro A, Antunes P, Lima D, Larson M, Gambús P, Amorim P. Pharmacodynamic modelling of the effect of remifentanil using the Pupillary Pain Index. J Clin Monit Comput. 2020 Apr; 34(2):319-324.
Behrends M, Larson MD, Neice AE, Bokoch MP. Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2019 Apr; 33(2):317-323.
McKay RE, Neice AE, Larson MD. Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions. A A Pract. 2018 May 15; 10(10):279-282.
Neice AE, Larson MD, Behrends M, Bokoch MP. In Response. Anesth Analg. 2017 08; 125(2):694-695.
Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Anesth Analg. 2017 03; 124(3):915-921.
Larson MD, Singh V. Portable infrared pupillometry in critical care. Crit Care. 2016 Jun 22; 20(1):161.
Larson MD, Behrends M. Portable infrared pupillometry: a review. Anesth Analg. 2015 Jun; 120(6):1242-53.
Larson MD, Gupta DK. Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics. Anesthesiology. 2015 May; 122(5):961-3.
Bokoch MP, Behrends M, Neice A, Larson MD. Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May; 189:68-74.
Rollins MD, Feiner JR, Lee JM, Shah S, Larson M. Pupillary effects of high-dose opioid quantified with infrared pupillometry. Anesthesiology. 2014 Nov; 121(5):1037-44.
Behrends M, Niemann CU, Larson MD. Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series. Resuscitation. 2012 Oct; 83(10):1223-8.
Larson MD, Sessler DI. Pupillometry to guide postoperative analgesia. Anesthesiology. 2012 May; 116(5):980-2.
Stites-Hallett N, Larson MD. Procedure-specific guidelines. Anesthesiology. 2010 Aug; 113(2):502-3; author reply 503.
Eilers H, Larson MD. The effect of ketamine and nitrous oxide on the human pupillary light reflex during general anesthesia. Auton Neurosci. 2010 Jan 15; 152(1-2):108-14.
Larson MD. Mechanism of opioid-induced pupillary effects. Clin Neurophysiol. 2008 Jun; 119(6):1358-64.
Larson MD, Fung RS, Infosino AJ, Baba A. Efficacy of epidural block during general anesthesia. Anesthesiology. 2006 Sep; 105(3):632-3.
Larson MD, Senturk M. Induction rooms. Bull Anesth Hist. 2006 Apr; 24(2):22-4.
Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT. Evaluation of the portable infrared pupillometer. Neurosurgery. 2005 Jul; 57(1):198-203; discussion 198-203.
Kollars JP, Larson MD. Tolerance to miotic effects of opioids. Anesthesiology. 2005 Mar; 102(3):701.
Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs. 2005 Feb; 37(1):34-40.
Larson MD, Berry PD, May J, Bjorksten A, Sessler DI. Latency of pupillary reflex dilation during general anesthesia. J Appl Physiol (1985). 2004 Aug; 97(2):725-30.
Yang LL, Niemann CU, Larson MD. Mechanism of pupillary reflex dilation in awake volunteers and in organ donors. Anesthesiology. 2003 Dec; 99(6):1281-6.
Larson MD. The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia. Anesth Analg. 2003 Dec; 97(6):1652-1656.
Larson MD, May J. Effect of asphyxia on the pupils of brain dead subjects. Resuscitation. 2002 Oct; 55(1):31-6.
Manley GT, Larson MD. Infrared pupillometry during uncal herniation. J Neurosurg Anesthesiol. 2002 Jul; 14(3):223-8.
Ikeda T, Kurz A, Sessler DI, Go J, Kurz M, Belani K, Larson M, Bjorksten AR, Dechert M, Christensen R. The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine. Ann N Y Acad Sci. 1997 Mar 15; 813:792-8.
Larson, Merlin D.. Alteration of Human Pupillary Light Reflex by General Anesthesia. Anesthesiology Review. 1989; XVI(3):25-29.
Larson, Merlin D.. Anaesthesia. Miotic effects of Opioids. 1987; 42(May):566.
Larson, Merlin D.. Pupillary Effects of General Anesthesia. Anesthesiology Review. 1985; 13(Jan/Feb):25-31.