Biography Dr. Legrand is a clinician scientist practicing critical care medicine and anesthesiology. His professional interests include diagnosing and optimum treatments of shock, the diagnosis, pathophysiology, and treatment of acute kidney injury and outcomes after major surgery and critical illness. He cares for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting both the short and long-term consequences of critical illnesses. His research interests have been focusing on the development and validation of acute illness biomarkers, mostly in the setting of sepsis, shock and Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. He has investigated diagnostic and therapeutic interventions associated with outcomes in severely ill patients. Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012. Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital. He is now Professor and director of Clinical research in the department of Anesthesiology and Perioperative medicine of the University of California San Francisco. Role Faculty Location UCSF at Mount Zion UCSF at Parnassus Category Clinical Research Specialties Critical Care Medicine Education Full Professor, 2017 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityResearch director, 2016 - , Paris Diderot UniversityAssociated Professor, 2013 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityPhD, 2012 - Renal physiology, Paris Diderot UniversityAssistant Professor, 2010 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityResidency, 2010 - Anesthesiology and Critical Care Medicine, Pierre and Marie Curie UniversityMSc, 2007 - Cardiovascular physiology, Paris Diderot UniversityMD, 2003 - , Toulouse Rangueil Univeristy Publications The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II. Legrand M, Khanna AK, Ostermann M, Kotani Y, Ferrer R, Girardis M, Leone M, DePascale G, Pickkers P, Tissieres P, Annoni F, Kotfis K, Landoni G, Zarbock A, Wieruszewski PM, De Backer D, Vincent JL, Bellomo R Adjusting risk of acute kidney injury for time on controlled mechanical ventilation in acute respiratory distress syndrome: victim or partner in crime? Authors' reply. Antonucci E, Chen D, Legrand M Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study. Dudoignon E, Chevret S, Tsague S, Hamane S, Chaouat M, Plaud B, Vicault E, Mebazaa A, Legrand M, Alanio A, Denis B, Dépret F, Dellière S Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial. Legrand M, Falcone J, Cholley B, Charbonneau H, Delaporte A, Lemoine A, Garot M, Joosten A, Meistelman C, Cheron-Leroy D, Rives JP, Pastene B, Dewitte A, Sigaut S, Danguy des Deserts M, Truc C, Boisson M, Lasocki S, Cuvillon P, Schiff U, Jaber S, Le Guen M, Caillard A, Bar S, Pereira de Souza Neto E, Colas V, Dimache F, Girardot T, Jozefowicz E, Viquesnel S, Berthier F, Vicaut E, Gayat E, Stop-or-Not Trial Group Biomarkers in acute kidney injury. Ostermann M, Legrand M, Meersch M, Srisawat N, Zarbock A, Kellum JA Decision-making in Perioperative Oliguria: Reply. Legrand M, McCoy IE, Tallarico RT Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE? Fuhrman DY, Bagshaw SM, Goldstein SL, Legrand M, Shaw AD Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach. Boutin L, Soussi S, Garcia Lavello A, Masson Fron E, Deniau B, Legrand M, Blot-Chabaud M, Figueroa SM, Chadjichristos CE, Azibani F, Dépret F Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement. Zarbock A, Forni LG, Koyner JL, Bell S, Reis T, Meersch M, Bagshaw SM, Fuhmann DY, Liu KD, Pannu N, Arikan AA, Angus DC, Duquette D, Goldstein SL, Hoste E, Joannidis M, Jongs N, Legrand M, Mehta RL, Murray PT, Nadim MK, Ostermann M, Prowle J, See EJ, Selby NM, Shaw AD, Srisawat N, Ronco C, Kellum JA Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections: A Review. Pirracchio R, Venkatesh B, Legrand M Intraoperative blood pressure management during kidney transplantation: grafts under pressure. Adelmann D, Legrand M Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials. Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M Hemodynamic Support in Sepsis. Antonucci E, Garcia B, Legrand M Correction: Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury. Joosten A, Ickx B, Mokhtari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der Linden P Using diuretic therapy in the critically ill patient. Ostermann M, Awdishu L, Legrand M Serial lactate measurements to guide resuscitation: more evidence not to? Legrand M, van der Horst ICC, De Jong A One-Year Survival and Hospital-free Days in Critical Illness After Viral Pneumonia. Atramont A, Martin GL, Singer M, Tajahmady A, Agamaliyev E, Harhay MO, Leone M, Legrand M Should renin-angiotensin system inhibitors be held prior to major surgery? Legrand M Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Legrand M, Bagshaw SM, Bhatraju PK, Bihorac A, Caniglia E, Khanna AK, Kellum JA, Koyner J, Harhay MO, Zampieri FG, Zarbock A, Chung K, Liu K, Mehta R, Pickkers P, Ryan A, Bernholz J, Dember L, Gallagher M, Rossignol P, Ostermann M Meaning and Management of Perioperative Oliguria. Tallarico RT, McCoy IE, Dépret F, Legrand M Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force. Wieruszewski PM, Leone M, Kaas-Hansen BS, Dugar S, Legrand M, McKenzie CA, Bissell Turpin BD, Messina A, Nasa P, Schorr CA, De Waele JJ, Khanna AK Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA. Lazzareschi DV, Luo Y, Fong N, Boscardin J, Legrand M, Chen CL The Need for Change in Generating Evidence for the Critically Ill. Legrand M, Pletcher MJ, Kim SYH An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury. Milton-Jones H, Soussi S, Davies R, Charbonney E, Charles WN, Cleland H, Dunn K, Gantner D, Giles J, Jeschke M, Lee N, Legrand M, Lloyd J, Martin-Loeches I, Pantet O, Samaan M, Shelley O, Sisson A, Spragg K, Wood F, Yarrow J, Vizcaychipi MP, Williams A, Leon-Villapalos J, Collins D, Jones I, Singh S The alternative renin-angiotensin system in critically ill patients: pathophysiology and therapeutic implications. Garcia B, Zarbock A, Bellomo R, Legrand M Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial. Bokoch MP, Tran AT, Brinson EL, Marcus SG, Reddy M, Sun E, Roll GR, Pardo M, Fields S, Adelmann D, Kothari RP, Legrand M Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury. De Tymowski C, Dépret F, Dudoignon E, Moreno N, Zagdanski AM, Hodjat K, Deniau B, Mebazaa A, Legrand M, Mallet V, Keta-Cov research group Acute kidney injury in patients with burns. Legrand M, Clark AT, Neyra JA, Ostermann M The role of renin-angiotensin system in sepsis-associated acute kidney injury: mechanisms and therapeutic implications. Garcia B, Zarbock A, Bellomo R, Legrand M Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis. Boutin L, Latosinska A, Mischak H, Deniau B, Asakage A, Legrand M, Gayat E, Mebazaa A, Chadjichristos CE, Depret F Impact of Vasodilator Administration on Survival in Patients with Sepsis: A Systematic Review and Meta-Analysis. Mavrothalassitis OY, Allen IE, Lazzareschi DV, Tahir P, Legrand M Tackling sepsis-associated acute kidney injury using routinely collected data. Claure-Del Granado R, James MT, Legrand M Breaking Down the Evidence: Does Perioperative Hypotension Cause Kidney Injury? Antonucci E, Prado VE, Legrand M Adjunctive vasopressors in distributive shock: How soon is early? Garcia B, Legrand M Leveraging observational data to identify targeted patient populations for future randomized trials. Lazzareschi DV, Fong N, Pirracchio R, Mathis MR, Legrand M Intraoperative hypotension is bad but could the treatment be even worse? Leone M, Joosten A, Legrand M Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting. Lazzareschi D, Mehta RL, Dember LM, Bernholz J, Turan A, Sharma A, Kheterpal S, Parikh CR, Ali O, Schulman IH, Ryan A, Feng J, Simon N, Pirracchio R, Rossignol P, Legrand M Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial. Legrand M, Kothari R, Fong N, Palaniappa N, Boldt D, Chen LL, Kurien P, Gabel E, Sturgess-DaPrato J, Harhay MO, Pirracchio R, Bokoch MP, VEGA-1 trial investigators All intraoperative hypotension is not created equal - A call for an individualized approach. Khanna AK, Zarbock A, Legrand M Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes. Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators Letter to the editor: "Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function". Legrand M, Gayat E Days Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data. Martin GL, Atramont A, Mazars M, Tajahmady A, Agamaliyev E, Singer M, Leone M, Legrand M Pragmatic platform trials to improve the outcome of patients with acute kidney injury. Tallarico RT, Neto AS, Legrand M Capillary refill time for the management of acute circulatory failure: a survey among pediatric and adult intensivists. Jacquet-Lagrèze M, Wiart C, Schweizer R, Didier L, Ruste M, Coutrot M, Legrand M, Baudin F, Javouhey E, Dépret F, Fellahi JL Could Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes? Burtscher J, Vanderriele PE, Legrand M, Predel HG, Niebauer J, O'Keefe JH, Millet GP, Burtscher M Optimizing the Design and Analysis of Future AKI Trials. Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO Differences in HADS and SF-36 scores 1 year after critical illness in COVID-19 patients. Tallarico RT, Deniau B, Fong N, Ghosn J, Legrand M, French-COVID and the FROG-ICU Investigators Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, Kalfon P, Constantin JM, Rousseau A, Simon T, Foucrier A, iDIAPASON Trial Investigators Risk factors of long term symptoms and outcomes among patients discharged after covid-19: prospective, multicentre observational study. Legrand M, Fong N, Laouénan C, Ghosn J, Thill B, Faure K, Garot D, Goujard C, Curlier E, Resche-Rigon M, Rossignol P, Pirracchio R Fluids, vasopressors, and acute kidney injury after major abdominal surgery between 2015 and 2019: a multicentre retrospective analysis. Chiu C, Fong N, Lazzareschi D, Mavrothalassitis O, Kothari R, Chen LL, Pirracchio R, Kheterpal S, Domino KB, Mathis M, Legrand M Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, Kalfon P, Constantin JM, Rousseau A, Simon T, Foucrier A, iDIAPASON Trial Investigators Ten tips to optimize vasopressors use in the critically ill patient with hypotension. Legrand M, Zarbock A Peace, not war in Ukraine or anywhere else, please. Lefrant JY, Pirracchio R, Benhamou D, Fischer MO, Njeim R, Allaouchiche B, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Clausen N, Cuvillon P, Dadure C, David JS, Du B, Einav S, Eley V, Forget P, Fujii T, Godier A, Gopalan DP, Hamada S, Hasanin A, Joannes-Boyau O, Kerever S, Kipnis É, Kolodzie K, Landau R, Le Gall A, Le Guen M, Legrand M, Lorne E, Mercier FJ, Mongardon N, Myatra S, Nicolas-Robin A, John Peters M, Quintard H, Rello J, Richebé P, Roberts JA, Rocquilly A, Sanfilippo F, Schneider A, Sofonea MT, Veyckemans F, Zetlaoui P, Zeidan A, Zieleskiewicz L, Zielinska M, Von Ungern-Sternberg B, Abou Arab O, Blet A, Bounes F, Boisson M, Caillard A, Carillion A, Clavier T, Frasca D, James A, Sigaut S, Rozencwajg S, Albaladejo P, Bouaziz H Digital health and artificial intelligence in kidney research: a report from the 2020 Kidney Disease Clinical Trialists (KDCT) meeting. Yi TW, Laing C, Kretzler M, Nkulikiyinka R, Legrand M, Jardine M, Rossignol P, Smyth B Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target. Boutin L, Dépret F, Gayat E, Legrand M, Chadjichristos CE Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission. Schnell D, Bourmaud A, Reynaud M, Rouleau S, Merdji H, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Darmon M Usefulness of lactate albumin ratio at admission to predict 28-day mortality in critically ill severely burned patients: A retrospective cohort study. Dudoignon E, Quennesson T, De Tymowski C, Moreno N, Coutrot M, Chaussard M, Guillemet L, Abid S, Fratani A, Ressaire Q, Cupaciu A, Weinmann V, Pharaboz A, Benyamina M, Mebazaa A, Legrand M, Depret F, Deniau B, PRONOBURN Group Ventilation practices in burn patients-an international prospective observational cohort study. Schultz MJ, Horn J, Hollmann MW, Preckel B, Glas GJ, Colpaert K, Malbrain M, Neto AS, Asehnoune K, de Abreu MG, Martin-Loeches I, Pelosi P, Sjöberg F, Binnekade JM, Cleffken B, Juffermans NP, Knape P, Loef BG, Mackie DP, Enkhbaatar P, Depetris N, Perner A, Herrero E, Cachafeiro L, Jeschke M, Lipman J, Legrand M, Horter J, Lavrentieva A, Glas G, Kazemi A, Guttormsen AB, Huss F, Kol M, Wong H, Starr T, De Crop L, de Oliveira Filho W, Manoel Silva Junior J, Grion CMC, Jeschke MG, Burnett M, Mondrup F, Ravat F, Fontaine M, Asehoune K, Floch RL, Jeanne M, Bacus M, Chaussard M, Lehnhardt M, Mikhail BD, Gille J, Sharkey A, Trommel N, Reidinga AC, Vieleers N, Tilsley A, Onarheim H, Bouza MT, Agrifoglio A, Fredén F, Palmieri T, Painting LE, LAMiNAR investigators Further evidence in support of closed ICUs. Legrand M, Aldrich M 2021 adaptation of the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Lefrant JY, Pirracchio R, Benhamou D, Njeim R, Ausset S, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Cuvillon P, Dadure C, David JS, Bin D, Fischer MO, Forget P, Fujii T, Godier A, Gopalan DP, Hamada S, Joannes-Boyau O, Kerever S, Kipnis É, Kolodzie K, Landau R, Le Gall A, Le Guen M, Legrand M, Lonnqvist PA, Lorne E, Mercier F, Mongardon N, Nicolas-Robin A, Peters MJ, Quintard H, Rello J, Richebe P, Roberts JA, Rocquilly A, Schneider A, Veyckemans F, Zetlaoui P, Abou Arab O, Blet A, Bounes F, Boisson M, Caillard A, Carillon A, Clavier T, Frasca D, James A, Sigaut S, Rozencwajg S, Bouaziz H Outcome of surgical patients during the first wave of the COVID-19 pandemic in US hospitals. Mavrothalassitis O, Pirracchio R, Fong N, Lazzareschi D, Sharma A, Vaughn MT, Mathis M, Legrand M Characteristics and prognosis of Herpesviridae-related pneumonia in critically ill burn patients. Dépret F, Riaud C, Rouaux J, Chaussard M, Fratani A, Cupaciu A, Coutrot M, Guillemet L, Oueslati H, Benyamina M, Mebazaa A, Lafaurie M, Serror K, Chaouat M, Salmona M, Legoff J, Legrand M Ketamine-induced cholangiopathy in ARDS patients. de Tymowski C, Dépret F, Dudoignon E, Legrand M, Mallet V, Keta-Cov Research Group Kidney Replacement Therapy in the ICU: Less Is More (Death)? Legrand M, Liu KD Pathophysiology of COVID-19-associated acute kidney injury. Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Pickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M Goal-directed Therapy and Postcystectomy Ileus: Comment. Joosten A, Alexander B, Legrand M, Duranteau J The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury. Legrand M, Bokoch MP Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury. Joosten A, Ickx B, Mokthari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der Linden P Outcome of acute kidney injury: how to make a difference? Jamme M, Legrand M, Geri G Epidemiology of sepsis and septic shock. Chiu C, Legrand M Anticoagulation strategies in continuous renal replacement therapy. Legrand M, Tolwani A Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock. Moins-Teisserenc H, Cordeiro DJ, Audigier V, Ressaire Q, Benyamina M, Lambert J, Maki G, Homyrda L, Toubert A, Legrand M Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J Complications in Patients With COVID-19. Legrand M Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study. Blet A, Deniau B, Santos K, van Lier DPT, Azibani F, Wittebole X, Chousterman BG, Gayat E, Hartmann O, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, Mebazaa A, AdrenOSS-1 Study Investigators Assessing the importance of interleukin-6 in COVID-19 - Authors' reply. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroianni F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers? Joffre J, Legrand M Goal-directed therapy and development of acute kidney injury. Joosten A, Alexander B, Duranteau J, Legrand M Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains. Legrand M, Liu K Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA The A2B trial, antibiotic prophylaxis for excision-graft surgery in burn patients: a multicenter randomized double-blind study. Dépret F, Farny B, Jeanne M, Klouche K, Leclerc T, Nouette-Gaulain K, Pantet O, Rémerand F, Roquilly A, Rousseau AF, Sztajnic S, Wiramus S, Vicaut E, Legrand M, A2B trial investigators Choice of fluid for critically ill patients: An overview of specific situations. Joannes-Boyau O, Roquilly A, Constantin JM, Duracher-Gout C, Dahyot-Fizelier C, Langeron O, Legrand M, Mirek S, Mongardon N, Mrozek S, Muller L, Orban JC, Virat A, Leone M, Critical Care Committee of the French Society of Anaesthesia and Intensive Care (SFAR) Response of US hospitals to elective surgical cases in the COVID-19 pandemic. Pirracchio R, Mavrothalassitis O, Mathis M, Kheterpal S, Legrand M Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA Incidence and Outcome of Subclinical Acute Kidney Injury Using penKid in Critically Ill Patients. Dépret F, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Leone M, Guidet B, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Struck J, Hartmann O, Mebazaa A, Gayat E, Legrand M Cardiovascular Consequences of Acute Kidney Injury. Reply. Legrand M, Rossignol P Insulin glucose infusion versus nebulised salbutamol versus combination of salbutamol and insulin glucose in acute hyperkalaemia in the emergency room: protocol for a randomised, multicentre, controlled study (INSAKA). Montassier E, Lemoine L, Hardouin JB, Rossignol P, Legrand M Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department. Abensur Vuillaume L, Ferreira JP, Asseray N, Trombert-Paviot B, Montassier E, Legrand M, Girerd N, Boivin JM, Chouihed T, Rossignol P Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Khorashadi M, Beunders R, Pickkers P, Legrand M Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G Practical management of worsening renal function in outpatients with heart failure and reduced ejection fraction: Statement from a panel of multidisciplinary experts and the Heart Failure Working Group of the French Society of Cardiology. Mewton N, Girerd N, Boffa JJ, Courivaud C, Isnard R, Juillard L, Lamblin N, Legrand M, Logeart D, Mariat C, Meune E, Sabouret P, Sebbag L, Rossignol P The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Legrand M, Oufella HA, De Backer D, Duranteau J, Leone M, Levy B, Rossignol P, Vicaut E, Dépret F, I-MICRO trial investigators Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19. Dudoignon E, Moreno N, Deniau B, Coutrot M, Longer R, Amiot Q, Mebazaa A, Pirracchio R, Depret F, Legrand M Cardiovascular Consequences of Acute Kidney Injury. Legrand M, Rossignol P Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Meert AP, Borcoman E, Bisbal M, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L Outcome and characteristics of invasive fungal infections in critically ill burn patients: A multicenter retrospective study. Maurel V, Denis B, Camby M, Jeanne M, Cornesse A, Glavnik B, Alanio A, Rousseau AF, Lefloch R, Lagrange-Xelot M, Textoris J, Wiramus S, de Tymowski C, Legrand M Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Leisman DE, Deutschman CS, Legrand M Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients. Dépret F, Amzallag J, Pollina A, Fayolle-Pivot L, Coutrot M, Chaussard M, Santos K, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Benyamina M, Guillemet L, Deniau B, Mebazaa A, Gayat E, Farny B, Textoris J, Legrand M, PRONOBURN group Point-of-care serum kalemia measurement accuracy. Depret F, Bonnart Latry D, Gayat E, Plaisance P, Legrand M Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial. Maurel V, Legrand M, Bourgeois E, Masse AL, Bergeron A, Binakdane F, Ntahe A, Legouge M, Vicaut E, Plaud B Should we ban hydroethyl starches from the operating theatre? PRO. Legrand M, Pirracchio R Management of severe thermal burns in the acute phase in adults and children. Legrand M, Barraud D, Constant I, Devauchelle P, Donat N, Fontaine M, Goffinet L, Hoffmann C, Jeanne M, Jonqueres J, Leclerc T, Lefort H, Louvet N, Losser MR, Lucas C, Pantet O, Roquilly A, Rousseau AF, Soussi S, Wiramus S, Gayat E, Blet A Utility of anaerobic bottles for the diagnosis of bloodstream infections. Lafaurie M, d'Anglejan E, Donay JL, Glotz D, Sarfati E, Mimoun M, Legrand M, Oksenhendler E, Bagot M, Valade S, Bercot B, Molina JM Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Khorashadi M, Bokoch MP, Legrand M Physiological response to fluid resuscitation with Ringer lactate versus Plasmalyte in critically ill burn patients. Chaussard M, Dépret F, Saint-Aubin O, Benyamina M, Coutrot M, Jully M, Oueslati H, Fratani A, Cupaciu A, Poniard A, Asehnoune K, Dimby SF, Mebazaa A, Houze P, Legrand M Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits? Legrand M, Alexander B, Joosten A PenKid measurement at admission is associated with outcome in severely ill burn patients. Dépret F, Polina A, Amzallag J, Fayolle-Pivot L, Coutrot M, Chaussard M, Struck J, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Soussi S, Benyamina M, Guillemet L, Mebazaa A, Textoris J, Legrand M, PRONOBURN group Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergová Pavkova M, Jarkovský J, Spinar J, Tomandlova M, Dastych M, Ince C, Helanova K, Tesak M, Helan M, Lokaj P, Legrand M, GREAT Network Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, Barbier F, Constantin JM, Clavier T, du Cheyron D, Terzi N, Sauneuf B, Guerot E, Lafon T, Herbland A, Megarbane B, Leclerc T, Mallet V, Pirracchio R, Legrand M Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section. Ostermann M, Schneider A, Rimmele T, Bobek I, van Dam M, Darmon M, Forni L, Joannes-Boyau O, Joannidis M, Legrand M, Prowle J, Zarbock A, Hoste E One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study. Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Launay JM, Ishihara S, Sato N, Mebazaa A, Gayat E, French and euRopean Outcome reGistry in ICUs (FROG-ICU) Investigators Tailoring treatment of hyperkalemia. Coutrot M, Dépret F, Legrand M Untitled Publication Lefort H, Legrand M The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy. Legrand M, Prowle JR, Forni LG Monitoring tissue perfusion: a pilot clinical feasibility and safety study of a urethral photoplethysmography-derived perfusion device in high-risk patients. Dépret F, Leone M, Duclos G, Futier E, Montagne M, Legrand M, Allaouchiche B Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery. Redant S, Legrand M, Langman Y, Aguilar AG, Angoulvant F, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway. Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F, Launay JM, Kane B, Kinugasa S, Prakoura N, Vandermeersch S, Cohen-Solal A, Delcayre C, Samuel JL, Mehta R, Gayat E, Mebazaa A, Chadjichristos CE, Legrand M Urgent need for a randomized controlled trial with only septic patients! Redant S, Legrand M, Langman Y, Garcia Aguilar A, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study. de Tymowski C, Pallado S, Anstey J, Depret F, Moreno N, Benyamina M, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Chaussard M, Guillemet L, Dudoignon E, Mimoun M, Chaouat M, Mebazaa A, Legrand M, Soussi S, PRONOBURN group Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B Reply to: "Potential role of ketamine in burn-associated cholestasis". Legrand M, de Tymowski C, Hodjat K, Mallet V Correction to: Recruiting the microcirculation in septic shock. Legrand M, De Backer D, Dépret F, Ait-Oufella H Management of Burns. Legrand M, Dépret F, Mallet V Recruiting the microcirculation in septic shock. Legrand M, De Backer D, Dépret F, Ait-Oufella H Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle. Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B, TRAUMABASE Group Understanding the renal response to brain injury. Legrand M, Sonneville R Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments. Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU. Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M, FROG-ICU investigators Is Nitric Oxide Nephro- or Cardioprotective? Coutrot M, Dépret F, Legrand M Contributing factors and outcomes of burn-associated cholestasis. de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M, PRONOBURN group Acute Kidney Injury Related to Sepsis-Reply. Legrand M, Kellum JA Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa. Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A, on behalf the ATB PK/PD study group Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings? Dudoignon E, Dépret F, Legrand M Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial). Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E, STOP-OR-NOT study investigators Management of hyperkalemia in the acutely ill patient. Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive c Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C, BLUE-CarbA study group. Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study. Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, Legrand M, PRONOBURN group Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn. Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, AdrenOSS-1 study investigators Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study. Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S, PRONOBURN group Serum Creatinine in the Critically Ill Patient With Sepsis. Legrand M, Kellum JA Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis. Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M Hydroxocobalamin as a Cause of Oxalate Nephropathy. Legrand M French intensive care unit organisation. Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit? Schetz M, Legrand M Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol. Montassier E, Legrand M, Rossignol P, Potel G Prediction of major adverse kidney events in critically ill burn patients. Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients. Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S Negative trials in critical care medicine and the hurdles. Legrand M Early Hemodynamic Management of Critically Ill Burn Patients. Soussi S, Dépret F, Benyamina M, Legrand M New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis. Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study. Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M Hemodynamic management of critically ill burn patients: an international survey. Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M, ESICM Burn ICU working group Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone. Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K When ethics collides with a legal gap in emergency life-threatening conditions. Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury. Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M, FROG-ICU investigators Could resuscitation be based on microcirculation data? Yes. Legrand M, Ait-Oufella H, Ince C Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A Cardiac output and CVP monitoring… to guide fluid removal. Legrand M, Soussi S, Depret F Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M, PRONOBURN group Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge. Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T, AzuRéa Group Tolvaptan in Later-Stage Polycystic Kidney Disease. De Tymowski C, Legrand M Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report. Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M, FROG ICU study investigators Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable? Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M, PRONOBURN study group Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, Plaisance P, Spinar J, Kosiborod M, Mebazaa A, Gayat E, GREAT (Global Research on Acute Conditions Team) Network and INI-CRCT (Investigation Network Initiat Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms. Serror K, Chaouat M, Legrand MM, Depret F, Haddad J, Malca N, Mimoun M, Boccara D Pressure guided surgery of compartment syndrome of the limbs in burn patients. Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients. Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M, PRONOBURN group Intravenous iloprost to recruit the microcirculation in septic shock patients? Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M Intravenous hydroxocobalamin and crystal nephropathy. Legrand M, Mallet V Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit. Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM On-line plasma lactate concentration monitoring in critically ill patients. De Tymowski C, Soussi S, Depret F, Legrand M A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Dépret F, Prud'homme M, Legrand M Are capillary and arterial lactates interchangeable? Dépret F, Legrand M Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Harjola VP, Mullens W, Banaszewski M, Bauersachs J, Brunner-La Rocca HP, Chioncel O, Collins SP, Doehner W, Filippatos GS, Flammer AJ, Fuhrmann V, Lainscak M, Lassus J, Legrand M, Masip J, Mueller C, Papp Z, Parissis J, Platz E, Rudiger A, Ruschitzka F, Schäfer A, Seferovic PM, Skouri H, Yilmaz MB, Mebazaa A Imbalanced Angiogenesis in Peripartum Cardiomyopathy - Diagnostic Value of Placenta Growth Factor. Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, Sadoune M, Sarb J, Arrigo M, Motiejunaite J, Laribi S, Legrand M, Deschamps L, Fazal L, Bouadma L, Collet C, Manivet P, Solal AC, Launay JM, Samuel JL, Sliwa K A nephrologist should be consulted in all cases of acute kidney injury in the ICU: We are not sure. Schetz M, Legrand M Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference. Bellomo R, Ronco C, Mehta RL, Asfar P, Boisramé-Helms J, Darmon M, Diehl JL, Duranteau J, Hoste EAJ, Olivier JB, Legrand M, Lerolle N, Malbrain MLNG, Mårtensson J, Oudemans-van Straaten HM, Parienti JJ, Payen D, Perinel S, Peters E, Pickkers P, Rondeau E, Schetz M, Vinsonneau C, Wendon J, Zhang L, Laterre PF Diagnostic work-up and specific causes of acute kidney injury. Darmon M, Ostermann M, Cerda J, Dimopoulos MA, Forni L, Hoste E, Legrand M, Lerolle N, Rondeau E, Schneider A, Souweine B, Schetz M Infectious Complications and Immune/Inflammatory Response in Cardiogenic Shock Patients: A Prospective Observational Study. Parenica J, Jarkovsky J, Malaska J, Mebazaa A, Gottwaldova J, Helanova K, Litzman J, Dastych M, Tomandl J, Spinar J, Dostalova L, Lokaj P, Tomandlova M, Pavkova MG, Sevcik P, Legrand M, GREAT Network Empiric use of hydroxocobalamin in patients with smoke inhlation injury: Not so fast! Legrand M, Michel T Hemodynamic coherence in patients with burns. Soussi S, Legrand M Not all β-lactams are equal regarding neurotoxicity. Chaïbi K, Chaussard M, Soussi S, Lafaurie M, Legrand M Should we apply "early" initiation of renal replacement therapy to critically ill patients with acute kidney injury? Legrand M Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future. Rossignol P, Legrand M, Kosiborod M, Hollenberg SM, Peacock WF, Emmett M, Epstein M, Kovesdy CP, Yilmaz MB, Stough WG, Gayat E, Pitt B, Zannad F, Mebazaa A Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study. Soussi S, Deniau B, Ferry A, Levé C, Benyamina M, Maurel V, Chaussard M, Le Cam B, Blet A, Mimoun M, Lambert J, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group Understanding the kidney during acute respiratory failure. Darmon M, Legrand M, Terzi N Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment. Legrand M, Gits-Muselli M, Boutin L, Garcia-Hermoso D, Maurel V, Soussi S, Benyamina M, Ferry A, Chaussard M, Hamane S, Denis B, Touratier S, Guigue N, Fréalle E, Jeanne M, Shaal JV, Soler C, Mimoun M, Chaouat M, Lafaurie M, Mebazaa A, Bretagne S, Alanio A Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M, PRONOBURN Group Chloride toxicity in critically ill patients: What's the evidence? Soussi S, Ferry A, Chaussard M, Legrand M Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A What's new in focused assessment with sonography: ballistic trauma. Legrand M, Russell R Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study. Legrand M, Le Cam B, Perbet S, Roger C, Darmon M, Guerci P, Ferry A, Maurel V, Soussi S, Constantin JM, Gayat E, Lefrant JY, Leone M, support of the AZUREA network Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar), Société de réanimation de langue française (SRLF), Groupe francophone de réanimation et urgences pédiatriques (GFRUP), Société française de néphrologie (SFN) Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar), Société de réanimation de langue française (SRLF), Groupe francophone de réanimation et urgences pédiatriques (GFRUP), Société française de néphrologie (SFN) Heart rate variability and cardiac baroreflex inhibition-derived index predicts pain perception in burn patients. Papaioannou V, Chouvarda I, Gaertner E, Benyamina M, Ferry A, Maurel V, Soussi S, Blet A, Chaouat M, Plaud B, Mebazaa A, Legrand M, PRONOBURN Group Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure. Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC Use of Prophylactic Antibiotics in Mechanically Ventilated Patients With Burn Injuries. Legrand M, Lafaurie M Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients. Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A, PRONOBURN Study Group The new Sfar journals are in place. Plaud B, Lefrant JY, Editorial Board, Anaesthesia Critical Care & Pain Medicine Intravenous Fluids in AKI: A Mechanistically Guided Approach. Legrand M, Ince C Renal replacement therapy in adult and pediatric intensive care : Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emerge Vinsonneau C, Allain-Launay E, Blayau C, Darmon M, Ducheyron D, Gaillot T, Honore PM, Javouhey E, Krummel T, Lahoche A, Letacon S, Legrand M, Monchi M, Ridel C, Robert R, Schortgen F, Souweine B, Vaillant P, Velly L, Osman D, Van Vong L Cross-talk phenomenon during femoral transpulmonary thermodilution in a critically ill patient. Soussi S, Ferry A, Bahaji M, De Tymowski C, Legrand M Influence of the central venous site on the transpulmonary thermodilution parameters in critically ill burn patients. Soussi S, Sisso F, Maurel V, Oueslati H, Legrand M Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Kamel T, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis. Ressaire Q, Padoin C, Chaouat M, Maurel V, Alanio A, Ferry A, Soussi S, Benyamina M, Denis B, Mimoun M, Mebazaa A, Legrand M Fenoldopam and acute kidney injury. Legrand M, Darmon M, Joannidis M Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Toufik K, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL, Global Research on Acute Conditions Team (GREAT) Erratum to: Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D Ten tips for managing critically ill burn patients: follow the RASTAFARI! Legrand M, Guttormsen AB, Berger MM Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D Biomarkers for AKI improve clinical practice: yes. Legrand M, Darmon M Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL, Global Research on Acute Conditions Team (GREAT) Reply: To PMID 24667613. Legrand M, Payen D, Vallée F, Mateo J When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome. Legrand M, Mebazaa A, Ronco C, Januzzi JL Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, Lewington A Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2! Legrand M, Vallée F, Mateo J, Payen D 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Papaioannou V, Mebazaa A, Plaud B, Legrand M In reply. Legrand M, Payen D Etomidate and general anesthesia: the butterfly effect? Legrand M, Plaud B Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, Payen D Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. Legrand M, Pirracchio R, Rosa A, Petersen ML, Van der Laan M, Fabiani JN, Fernandez-gerlinger MP, Podglajen I, Safran D, Cholley B, Mainardi JL Novelties in biomarkers for the management of circulatory failure. Legrand M, Gayat E NGAL and AKI: the end of a myth? Legrand M, Darmon M, Joannidis M Critical research on biomarkers: what's new? Legrand M, Januzzi JL, Mebazaa A Case scenario: Hemodynamic management of postoperative acute kidney injury. Legrand M, Payen D The elusive task of biomarkers of renal injury. Legrand M, Mari A, Mebazaa A Transcranial Doppler monitoring may be misleading in prediction of elevated ICP in brain-injured patients. Ahmad M, Legrand M, Lukaszewicz AC, Charlier P, Mateo J, Payen D Accuracy of urine NGAL commercial assays in critically ill patients. Legrand M, Collet C, Gayat E, Henao J, Giraudeaux V, Mateo J, Launay JM, Payen D Management of renal replacement therapy in ICU patients: an international survey. Legrand M, Darmon M, Joannidis M, Payen D Diagnostic accuracy of insulin-like growth factor binding protein-1 for amniotic fluid embolism*. Legrand M, Rossignol M, Dreux S, Luton D, Ventré C, Barranger E, Laribi S, Payen D, Muller F A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype. Payen D, Lukaszewicz AC, Legrand M, Gayat E, Faivre V, Megarbane B, Azoulay E, Fieux F, Charron D, Loiseau P, Busson M Survival in neutropenic patients with severe sepsis or septic shock. Legrand M, Max A, Peigne V, Mariotte E, Canet E, Debrumetz A, Lemiale V, Seguin A, Darmon M, Schlemmer B, Azoulay E Can we identify prerenal physiology and does it matter? Payen D, Legrand M Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats. Legrand M, Kandil A, Payen D, Ince C The use of dabigatran in elderly patients. Legrand M, Mateo J, Aribaud A, Ginisty S, Eftekhari P, Huy PT, Drouet L, Payen D Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Legrand M, Bezemer R, Kandil A, Demirci C, Payen D, Ince C The strategy of antibiotic use in critically ill neutropenic patients. Legrand M, Max A, Schlemmer B, Azoulay E, Gachot B Arterial catheter-related bloodstream infections: results of an 8-year survey in a surgical intensive care unit. Pirracchio R, Legrand M, Rigon MR, Mateo J, Lukaszewicz AC, Mebazaa A, Raskine L, Le Pors MJ, Payen D Understanding urine output in critically ill patients. Legrand M, Payen D Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms. Bezemer R, Faber DJ, Almac E, Kalkman J, Legrand M, Heger M, Ince C Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. Bezemer R, Legrand M, Klijn E, Heger M, Post IC, van Gulik TM, Payen D, Ince C Intensity of continuous renal-replacement therapy. Legrand M, Payen D Echocardiography in hemodynamic monitoring. Chimot L, Legrand M, Canet E, Lemiale V, Azoulay E The response of the host microcirculation to bacterial sepsis: does the pathogen matter? Legrand M, Klijn E, Payen D, Ince C Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Legrand M, Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C The role of the microcirculation in acute kidney injury. Le Dorze M, Legrand M, Payen D, Ince C Microcirculation and mitochondria in sepsis: getting out of breath. Balestra GM, Legrand M, Ince C L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Legrand M, Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C Paediatric intracranial empyema: differences according to age. Legrand M, Roujeau T, Meyer P, Carli P, Orliaguet G, Blanot S Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Legrand M, Mik EG, Johannes T, Payen D, Ince C Pleural drain malposition. Legrand M, Lecuyer L, Van De Louw A, Thierry S Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J
