Biography Dr. Legrand is a clinician scientist practicing critical care medicine and anesthesiology. His professional interests include diagnosing and optimum treatments of shock, the diagnosis, pathophysiology, and treatment of acute kidney injury and outcomes after major surgery and critical illness. He cares for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting both the short and long-term consequences of critical illnesses. His research interests have been focusing on the development and validation of acute illness biomarkers, mostly in the setting of sepsis, shock and Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. He has investigated diagnostic and therapeutic interventions associated with outcomes in severely ill patients. Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012. Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital. He is now Professor and director of Clinical research in the department of Anesthesiology and Perioperative medicine of the University of California San Francisco. Role Faculty Location UCSF at Mount Zion UCSF at Parnassus Category Clinical Research Specialties Critical Care Medicine Education Full Professor, 2017 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityResearch director, 2016 - , Paris Diderot UniversityAssociated Professor, 2013 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityPhD, 2012 - Renal physiology, Paris Diderot UniversityAssistant Professor, 2010 - Anesthesiology and Critical Care Medicine, Paris Diderot UniversityResidency, 2010 - Anesthesiology and Critical Care Medicine, Pierre and Marie Curie UniversityMSc, 2007 - Cardiovascular physiology, Paris Diderot UniversityMD, 2003 - , Toulouse Rangueil Univeristy Publications Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial. Pirracchio R, Fong N, Legrand M Intensive care medicine . Sep 17, 2025 Efficacy and safety of prothrombin complex concentrate versus frozen plasma in cardiac surgery: a systematic review and meta-analysis with trial sequential analysis. Shalabi L, Ibrahim A, Zreigh S, Tawfik AM, Shalabi S, Rifai M, Legrand M British journal of anaesthesia . Sep 5, 2025 Preoperative Cardiovascular Risk and Postoperative Outcomes by Renin-Angiotensin System Inhibitor Use: A Secondary Analysis of a Randomized Clinical Trial. Tang J, Pirracchio R, Cholley B, Joosten A, Birckener J, Falcone J, Charbonneau H, Delaporte A, Chen D, Gayat E, Legrand M JAMA cardiology . Jun 25, 2025 High BMI at Liver Transplantation: A Retrospective Single-Center Analysis of Blood Product Utilization and Postoperative Outcomes. Zeiner S, Kothari RP, Reddy M, Mendez NV, Roll GR, Braun HJ, Bokoch MP, Kolodzie K, Kimberger O, Legrand M, Adelmann D American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Aug 27, 2025 Local adoption of norepinephrine as the first-line vasopressor in major noncardiac surgery: impact of a pragmatic clinical trial on real-world practice. Ansay C, Chawla SA, Fong N, Lin R, Chang JM, Whitlock EL, Kothari RP, Legrand M, Bokoch MP British journal of anaesthesia . Aug 16, 2025 Anesthesiology Clinical Trial Networks in the United States: A Report From the Anesthesia Research Council. Hua M, BillingsIV FT, Aziz MF, Dutton R, Kheterpal S, Legrand M, Leslie K, Mathew JP, McCann ME, Subramaniam B, Treggiari MM, Wijeysundera DN, Gropper MA Anesthesia and analgesia . Aug 15, 2025 Anesthesiology Clinical Trial Networks in the United States: A Report from the Anesthesia Research Council. Hua M, Billings FT, Aziz MF, Dutton R, Kheterpal S, Legrand M, Leslie K, Mathew JP, McCann ME, Subramaniam B, Treggiari MM, Wijeysundera DN, Gropper MA Anesthesiology . Aug 12, 2025 Intraosseous versus intravenous vascular access in adults with out-of-hospital cardiac arrest: a meta-analysis with trial sequential analysis and meta-regression analysis. Ibrahim A, Shalabi L, Zreigh S, Ramadan S, Elsawy MA, Shat B, Legrand M European journal of emergency medicine : official journal of the European Society for Emergency Medicine . Aug 4, 2025 State of the art: Renal recovery after AKI - from basic science to clinical practice. Ostermann M, Forni LG, Joannidis M, Kane-Gill SL, Legrand M, Lumlertgul N, McNicholas B, Meersch M, Monard C, Pickkers P, Prowle J, Rimmelé T, Schneider A, Zarbock A, Kellum JA Intensive care medicine . Jul 28, 2025 Research without prior consent procedure and intervention effect on mortality in critical care: a meta-epidemiological study of randomized controlled trials. Hariri G, Louie J, Khan A, Tahir P, Martin GL, Dechartres A, Legrand M Critical care (London, England) . Jul 24, 2025 Ketamine and Traumatic Memory After Intensive Care Unit Discharge: Patient Population and Sedation Concerns. Legrand M, Constantin JM, Burry L, Sonneville R Anesthesia and analgesia . Jul 17, 2025 Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial. Legrand M, Jullien E, Kimmoun A, Geri G, Ait-Oufella H, Abrard S, Gaugain S, Bounes F, Guerci P, Pottecher J, Jamme M, Poncelin de Raucourt Y, Barraud D, Constantin JM, Juguet W, Lasocki S, Sonneville R, Audibert J, Plantefève G, Ellrodt O, Fedou AL, Leone M, Lefebvre L, Auvet A, Chen D, Vicaut E, Dépret F, I-MICRO trial investigators American journal of respiratory and critical care medicine . May 19, 2025 Postoperative Outcomes Among Sodium-Glucose Cotransporter 2 Inhibitor Users. Tallarico RT, Jing B, Lu K, Chawla SA, Luo Y, Badathala A, Chen CL, Wallace AW, Legrand M JAMA surgery . Apr 30, 2025 Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis. Antonucci E, Bokoch MP, Adelmann D, Kolodzie K, Roll GR, Sun E, Legrand M, Kothari R Transplantation direct . May 21, 2025 Evaluating the risks and benefits of continuing versus withholding renin-angiotensin system inhibitors: a systematic review and meta-analysis with trial sequential analysis. Shalabi L, Ibrahim A, Zreigh S, Rifai M, Ramadan S, Arafa MA, Mustafa OM, Ansab M, Krayem MF, Elsabbagh I, Mash'al NH, Waleed S, Legrand M BJA open . May 3, 2025 Therapeutic Potential of Centhaquine Citrate, a Selective Alpha-2B Adrenoceptor Agonist, in the Management of Circulatory Shock. Legrand M, Ranjan A, Rammohan S, De Backer D, Ostermann M, Gulati A, Vincent JL, Khanna AK Drugs . Apr 20, 2025 Alterations in the renin-angiotensin system during septic shock. Benaroua C, Pucci F, Rooman M, Picod A, Favory R, Legrand M, Vincent JL, Creteur J, Taccone FS, Annoni F, Garcia B Annals of intensive care . Mar 24, 2025 Advancing surgical outcomes through cardiovascular biomarker sub-phenotyping. Garcia B, Khanna AK, Legrand M British journal of anaesthesia . Mar 14, 2025 Cardiac index-guided haemodynamic management and myocardial injury after hepatopancreatic surgery. Boulos N, Delaporte A, Legrand M, Saugel B, Joosten A European journal of anaesthesiology . Mar 5, 2025 Expanding the role of PoCUS in tailoring diuretic strategies for congestion management in critical care: authors' reply. Ostermann M, Awdishu L, Legrand M Intensive care medicine . Feb 27, 2025 Safety and Feasibility of Early Extubation in Liver Transplantation: Experience in 1555 Patients. Lacom C, Kothari RP, Mendez NV, Galli A, Roll GR, Bokoch MP, Legrand M, Adelmann D Transplantation . Feb 14, 2025 Clinical team flow in the perioperative environment: a qualitative single-centre study. Coss NA, Sinskey JL, van den Hout J, Chang JM, Legrand M, Schwartz R British journal of anaesthesia . Jan 24, 2025 Management of renin-angiotensin system inhibitors prior to major surgery: insights from the STOP-or-NOT trial. Legrand M, Gayat E British journal of anaesthesia . Dec 13, 2024 Postoperative Delirium in a Randomized Trial of Intraoperative Norepinephrine versus Phenylephrine Infusion. Phero A, Bokoch MP, Kothari R, Fong N, Chen D, Pirracchio R, Legrand M, Whitlock EL Anesthesiology . Jan 1, 2025 How to manage sodium-glucose cotransporter-2 inhibitors in the critically ill patient? Garcia B, Ostermann M, Legrand M Intensive care medicine . Dec 2, 2024 The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II. Legrand M, Khanna AK, Ostermann M, Kotani Y, Ferrer R, Girardis M, Leone M, DePascale G, Pickkers P, Tissieres P, Annoni F, Kotfis K, Landoni G, Zarbock A, Wieruszewski PM, De Backer D, Vincent JL, Bellomo R Critical care (London, England) . Nov 26, 2024 Epidemiology of sepsis-associated acute kidney injury in critically ill patients: a multicenter, prospective, observational cohort study in South Korea. Song MJ, Jang Y, Legrand M, Park S, Ko R, Suh GY, Oh DK, Lee SY, Park MH, Lim CM, Jung SY, Lim SY, Korean Sepsis Alliance (KSA) investigator Critical care (London, England) . Nov 24, 2024 Adjusting risk of acute kidney injury for time on controlled mechanical ventilation in acute respiratory distress syndrome: victim or partner in crime? Authors' reply. Antonucci E, Chen D, Legrand M Intensive care medicine . Oct 17, 2024 Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study. Dudoignon E, Chevret S, Tsague S, Hamane S, Chaouat M, Plaud B, Vicault E, Mebazaa A, Legrand M, Alanio A, Denis B, Dépret F, Dellière S Clinical infectious diseases : an official publication of the Infectious Diseases Society of America . Sep 26, 2024 Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial. Legrand M, Falcone J, Cholley B, Charbonneau H, Delaporte A, Lemoine A, Garot M, Joosten A, Meistelman C, Cheron-Leroy D, Rives JP, Pastene B, Dewitte A, Sigaut S, Danguy des Deserts M, Truc C, Boisson M, Lasocki S, Cuvillon P, Schiff U, Jaber S, Le Guen M, Caillard A, Bar S, Pereira de Souza Neto E, Colas V, Dimache F, Girardot T, Jozefowicz E, Viquesnel S, Berthier F, Vicaut E, Gayat E, Stop-or-Not Trial Group JAMA . Aug 30, 2024 Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study. Windsor C, Joseph A, Pons S, Mokart D, Pène F, Kouatchet A, Demoule A, Bruneel F, Nyunga M, Borcoman E, Legrand M, Darmon M, Zafrani L, Azoulay E, Lemiale V Journal of intensive medicine . Sep 24, 2024 Biomarkers in acute kidney injury. Ostermann M, Legrand M, Meersch M, Srisawat N, Zarbock A, Kellum JA Annals of intensive care . Sep 15, 2024 New drugs for acute kidney injury. Hariri G, Legrand M Journal of intensive medicine . Sep 7, 2024 Decision-making in Perioperative Oliguria: Reply. Legrand M, McCoy IE, Tallarico RT Anesthesiology . Jul 15, 2024 Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE? Fuhrman DY, Bagshaw SM, Goldstein SL, Legrand M, Shaw AD Intensive care medicine . Aug 15, 2024 Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach. Boutin L, Soussi S, Garcia Lavello A, Masson Fron E, Deniau B, Legrand M, Blot-Chabaud M, Figueroa SM, Chadjichristos CE, Azibani F, Dépret F Cardiorenal medicine . Aug 12, 2024 Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement. Zarbock A, Forni LG, Koyner JL, Bell S, Reis T, Meersch M, Bagshaw SM, Fuhmann DY, Liu KD, Pannu N, Arikan AA, Angus DC, Duquette D, Goldstein SL, Hoste E, Joannidis M, Jongs N, Legrand M, Mehta RL, Murray PT, Nadim MK, Ostermann M, Prowle J, See EJ, Selby NM, Shaw AD, Srisawat N, Ronco C, Kellum JA Intensive care medicine . Aug 8, 2024 Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections: A Review. Pirracchio R, Venkatesh B, Legrand M JAMA . Jun 12, 2024 Intraoperative blood pressure management during kidney transplantation: grafts under pressure. Adelmann D, Legrand M American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . Jul 3, 2024 Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials. Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M Intensive care medicine . Jun 12, 2024 Hemodynamic Support in Sepsis. Antonucci E, Garcia B, Legrand M Anesthesiology . Jun 1, 2024 Correction: Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury. Joosten A, Ickx B, Mokhtari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der Linden P BMC anesthesiology . May 23, 2024 Using diuretic therapy in the critically ill patient. Ostermann M, Awdishu L, Legrand M Intensive care medicine . May 2, 2024 Serial lactate measurements to guide resuscitation: more evidence not to? Legrand M, van der Horst ICC, De Jong A Intensive care medicine . Apr 18, 2024 One-Year Survival and Hospital-free Days in Critical Illness After Viral Pneumonia. Atramont A, Martin GL, Singer M, Tajahmady A, Agamaliyev E, Harhay MO, Leone M, Legrand M American journal of respiratory and critical care medicine . Apr 15, 2024 Should renin-angiotensin system inhibitors be held prior to major surgery? Legrand M British journal of anaesthesia . Apr 4, 2024 Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Legrand M, Bagshaw SM, Bhatraju PK, Bihorac A, Caniglia E, Khanna AK, Kellum JA, Koyner J, Harhay MO, Zampieri FG, Zarbock A, Chung K, Liu K, Mehta R, Pickkers P, Ryan A, Bernholz J, Dember L, Gallagher M, Rossignol P, Ostermann M Critical care (London, England) . Mar 21, 2024 Meaning and Management of Perioperative Oliguria. Tallarico RT, McCoy IE, Dépret F, Legrand M Anesthesiology . Oct 9, 2023 Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M British journal of anaesthesia . Jan 18, 2024 Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force. Wieruszewski PM, Leone M, Kaas-Hansen BS, Dugar S, Legrand M, McKenzie CA, Bissell Turpin BD, Messina A, Nasa P, Schorr CA, De Waele JJ, Khanna AK Critical Care Medicine . Jan 19, 2024 Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA. Lazzareschi DV, Luo Y, Fong N, Boscardin J, Legrand M, Chen CL Canadian journal of anaesthesia = Journal canadien d'anesthesie . Dec 15, 2023 The Need for Change in Generating Evidence for the Critically Ill. Legrand M, Pletcher MJ, Kim SYH American journal of respiratory and critical care medicine . Dec 1, 2023 An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury. Milton-Jones H, Soussi S, Davies R, Charbonney E, Charles WN, Cleland H, Dunn K, Gantner D, Giles J, Jeschke M, Lee N, Legrand M, Lloyd J, Martin-Loeches I, Pantet O, Samaan M, Shelley O, Sisson A, Spragg K, Wood F, Yarrow J, Vizcaychipi MP, Williams A, Leon-Villapalos J, Collins D, Jones I, Singh S Critical care (London, England) . Nov 27, 2023 The alternative renin-angiotensin system in critically ill patients: pathophysiology and therapeutic implications. Garcia B, Zarbock A, Bellomo R, Legrand M Critical care (London, England) . Nov 20, 2023 Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial. Bokoch MP, Tran AT, Brinson EL, Marcus SG, Reddy M, Sun E, Roll GR, Pardo M, Fields S, Adelmann D, Kothari RP, Legrand M BMJ open . Nov 19, 2023 Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury. De Tymowski C, Dépret F, Dudoignon E, Moreno N, Zagdanski AM, Hodjat K, Deniau B, Mebazaa A, Legrand M, Mallet V, Keta-Cov research group JHEP reports : innovation in hepatology . Nov 2, 2023 Acute kidney injury in patients with burns. Legrand M, Clark AT, Neyra JA, Ostermann M Nature reviews. Nephrology . Sep 27, 2023 The role of renin-angiotensin system in sepsis-associated acute kidney injury: mechanisms and therapeutic implications. Garcia B, Zarbock A, Bellomo R, Legrand M Current opinion in critical care . Sep 21, 2023 Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis. Boutin L, Latosinska A, Mischak H, Deniau B, Asakage A, Legrand M, Gayat E, Mebazaa A, Chadjichristos CE, Depret F Intensive care medicine . Sep 5, 2023 Impact of Vasodilator Administration on Survival in Patients with Sepsis: A Systematic Review and Meta-Analysis. Mavrothalassitis OY, Allen IE, Lazzareschi DV, Tahir P, Legrand M Annals of the American Thoracic Society . Sep 1, 2023 Tackling sepsis-associated acute kidney injury using routinely collected data. Claure-Del Granado R, James MT, Legrand M Intensive care medicine . Aug 28, 2023 Breaking Down the Evidence: Does Perioperative Hypotension Cause Kidney Injury? Antonucci E, Prado VE, Legrand M Nephron . Jul 7, 2023 Adjunctive vasopressors in distributive shock: How soon is early? Garcia B, Legrand M Critical care (London, England) . May 30, 2023 Leveraging observational data to identify targeted patient populations for future randomized trials. Lazzareschi DV, Fong N, Pirracchio R, Mathis MR, Legrand M Research square . May 5, 2023 Intraoperative hypotension is bad but could the treatment be even worse? Leone M, Joosten A, Legrand M Anaesthesia, critical care & pain medicine . Apr 6, 2023 Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting. Lazzareschi D, Mehta RL, Dember LM, Bernholz J, Turan A, Sharma A, Kheterpal S, Parikh CR, Ali O, Schulman IH, Ryan A, Feng J, Simon N, Pirracchio R, Rossignol P, Legrand M Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . Mar 31, 2023 Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial. Legrand M, Kothari R, Fong N, Palaniappa N, Boldt D, Chen LL, Kurien P, Gabel E, Sturgess-DaPrato J, Harhay MO, Pirracchio R, Bokoch MP, VEGA-1 trial investigators British journal of anaesthesia . Mar 14, 2023 All intraoperative hypotension is not created equal - A call for an individualized approach. Khanna AK, Zarbock A, Legrand M Journal of clinical anesthesia . Mar 6, 2023 Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes. Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators Annals of surgery . Dec 14, 2022 Letter to the editor: "Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function". Legrand M, Gayat E Journal of critical care . Nov 8, 2022 Days Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data. Martin GL, Atramont A, Mazars M, Tajahmady A, Agamaliyev E, Singer M, Leone M, Legrand M Chest . Oct 17, 2022 Pragmatic platform trials to improve the outcome of patients with acute kidney injury. Tallarico RT, Neto AS, Legrand M Current opinion in critical care . Sep 28, 2022 Capillary refill time for the management of acute circulatory failure: a survey among pediatric and adult intensivists. Jacquet-Lagrèze M, Wiart C, Schweizer R, Didier L, Ruste M, Coutrot M, Legrand M, Baudin F, Javouhey E, Dépret F, Fellahi JL BMC emergency medicine . Jul 18, 2022 Could Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes? Burtscher J, Vanderriele PE, Legrand M, Predel HG, Niebauer J, O'Keefe JH, Millet GP, Burtscher M Sports medicine (Auckland, N.Z.) . Jul 18, 2022 Optimizing the Design and Analysis of Future AKI Trials. Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO Journal of the American Society of Nephrology : JASN . Jul 13, 2022 Differences in HADS and SF-36 scores 1 year after critical illness in COVID-19 patients. Tallarico RT, Deniau B, Fong N, Ghosn J, Legrand M, French-COVID and the FROG-ICU Investigators Intensive care medicine . Jul 8, 2022 Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, Kalfon P, Constantin JM, Rousseau A, Simon T, Foucrier A, iDIAPASON Trial Investigators Intensive care medicine . Jul 1, 2022 Risk factors of long term symptoms and outcomes among patients discharged after covid-19: prospective, multicentre observational study. Legrand M, Fong N, Laouénan C, Ghosn J, Thill B, Faure K, Garot D, Goujard C, Curlier E, Resche-Rigon M, Rossignol P, Pirracchio R BMJ medicine . Jun 17, 2022 Fluids, vasopressors, and acute kidney injury after major abdominal surgery between 2015 and 2019: a multicentre retrospective analysis. Chiu C, Fong N, Lazzareschi D, Mavrothalassitis O, Kothari R, Chen LL, Pirracchio R, Kheterpal S, Domino KB, Mathis M, Legrand M British journal of anaesthesia . Jun 8, 2022 Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, Kalfon P, Constantin JM, Rousseau A, Simon T, Foucrier A, iDIAPASON Trial Investigators Intensive care medicine . May 13, 2022 Ten tips to optimize vasopressors use in the critically ill patient with hypotension. Legrand M, Zarbock A Intensive care medicine . May 3, 2022 Peace, not war in Ukraine or anywhere else, please. Lefrant JY, Pirracchio R, Benhamou D, Fischer MO, Njeim R, Allaouchiche B, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Clausen N, Cuvillon P, Dadure C, David JS, Du B, Einav S, Eley V, Forget P, Fujii T, Godier A, Gopalan DP, Hamada S, Hasanin A, Joannes-Boyau O, Kerever S, Kipnis É, Kolodzie K, Landau R, Le Gall A, Le Guen M, Legrand M, Lorne E, Mercier FJ, Mongardon N, Myatra S, Nicolas-Robin A, John Peters M, Quintard H, Rello J, Richebé P, Roberts JA, Rocquilly A, Sanfilippo F, Schneider A, Sofonea MT, Veyckemans F, Zetlaoui P, Zeidan A, Zieleskiewicz L, Zielinska M, Von Ungern-Sternberg B, Abou Arab O, Blet A, Bounes F, Boisson M, Caillard A, Carillion A, Clavier T, Frasca D, James A, Sigaut S, Rozencwajg S, Albaladejo P, Bouaziz H Anaesthesia, critical care & pain medicine . Apr 20, 2022 Digital health and artificial intelligence in kidney research: a report from the 2020 Kidney Disease Clinical Trialists (KDCT) meeting. Yi TW, Laing C, Kretzler M, Nkulikiyinka R, Legrand M, Jardine M, Rossignol P, Smyth B Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . Mar 25, 2022 Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target. Boutin L, Dépret F, Gayat E, Legrand M, Chadjichristos CE International journal of molecular sciences . Mar 14, 2022 Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission. Schnell D, Bourmaud A, Reynaud M, Rouleau S, Merdji H, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Darmon M Journal of critical care . Jan 21, 2022 Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission. Boutin L, Legrand M, Sadoune M, Mebazaa A, Gayat E, Chadjichristos CE, Dépret F Critical care (London, England) . Jan 6, 2022 Usefulness of lactate albumin ratio at admission to predict 28-day mortality in critically ill severely burned patients: A retrospective cohort study. Dudoignon E, Quennesson T, De Tymowski C, Moreno N, Coutrot M, Chaussard M, Guillemet L, Abid S, Fratani A, Ressaire Q, Cupaciu A, Weinmann V, Pharaboz A, Benyamina M, Mebazaa A, Legrand M, Depret F, Deniau B, PRONOBURN Group Burns : journal of the International Society for Burn Injuries . Jan 5, 2022 Ventilation practices in burn patients-an international prospective observational cohort study. Schultz MJ, Horn J, Hollmann MW, Preckel B, Glas GJ, Colpaert K, Malbrain M, Neto AS, Asehnoune K, de Abreu MG, Martin-Loeches I, Pelosi P, Sjöberg F, Binnekade JM, Cleffken B, Juffermans NP, Knape P, Loef BG, Mackie DP, Enkhbaatar P, Depetris N, Perner A, Herrero E, Cachafeiro L, Jeschke M, Lipman J, Legrand M, Horter J, Lavrentieva A, Glas G, Kazemi A, Guttormsen AB, Huss F, Kol M, Wong H, Starr T, De Crop L, de Oliveira Filho W, Manoel Silva Junior J, Grion CMC, Jeschke MG, Burnett M, Mondrup F, Ravat F, Fontaine M, Asehoune K, Floch RL, Jeanne M, Bacus M, Chaussard M, Lehnhardt M, Mikhail BD, Gille J, Sharkey A, Trommel N, Reidinga AC, Vieleers N, Tilsley A, Onarheim H, Bouza MT, Agrifoglio A, Fredén F, Palmieri T, Painting LE, LAMiNAR investigators Burns & trauma . Dec 16, 2021 Further evidence in support of closed ICUs. Legrand M, Aldrich M Anaesthesia, critical care & pain medicine . Nov 5, 2021 2021 adaptation of the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Lefrant JY, Pirracchio R, Benhamou D, Njeim R, Ausset S, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Cuvillon P, Dadure C, David JS, Bin D, Fischer MO, Forget P, Fujii T, Godier A, Gopalan DP, Hamada S, Joannes-Boyau O, Kerever S, Kipnis É, Kolodzie K, Landau R, Le Gall A, Le Guen M, Legrand M, Lonnqvist PA, Lorne E, Mercier F, Mongardon N, Nicolas-Robin A, Peters MJ, Quintard H, Rello J, Richebe P, Roberts JA, Rocquilly A, Schneider A, Veyckemans F, Zetlaoui P, Abou Arab O, Blet A, Bounes F, Boisson M, Caillard A, Carillon A, Clavier T, Frasca D, James A, Sigaut S, Rozencwajg S, Bouaziz H Anaesthesia, critical care & pain medicine . Oct 1, 2021 Outcome of surgical patients during the first wave of the COVID-19 pandemic in US hospitals. Mavrothalassitis O, Pirracchio R, Fong N, Lazzareschi D, Sharma A, Vaughn MT, Mathis M, Legrand M British journal of anaesthesia . Oct 1, 2021 Characteristics and prognosis of Herpesviridae-related pneumonia in critically ill burn patients. Dépret F, Riaud C, Rouaux J, Chaussard M, Fratani A, Cupaciu A, Coutrot M, Guillemet L, Oueslati H, Benyamina M, Mebazaa A, Lafaurie M, Serror K, Chaouat M, Salmona M, Legoff J, Legrand M Burns : journal of the International Society for Burn Injuries . Sep 21, 2021 Ketamine-induced cholangiopathy in ARDS patients. de Tymowski C, Dépret F, Dudoignon E, Legrand M, Mallet V, Keta-Cov Research Group Intensive care medicine . Jul 27, 2021 Kidney Replacement Therapy in the ICU: Less Is More (Death)? Legrand M, Liu KD American journal of kidney diseases : the official journal of the National Kidney Foundation . Jul 7, 2021 Pathophysiology of COVID-19-associated acute kidney injury. Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V Nature reviews. Nephrology . Jul 5, 2021 Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Pickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M Intensive care medicine . Jul 2, 2021 Goal-directed Therapy and Postcystectomy Ileus: Comment. Joosten A, Alexander B, Legrand M, Duranteau J Anesthesiology . May 1, 2021 The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury. Legrand M, Bokoch MP American journal of respiratory and critical care medicine . May 1, 2021 Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury. Joosten A, Ickx B, Mokthari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der Linden P BMC anesthesiology . Apr 30, 2021 Outcome of acute kidney injury: how to make a difference? Jamme M, Legrand M, Geri G Annals of intensive care . Apr 15, 2021 Epidemiology of sepsis and septic shock. Chiu C, Legrand M Current opinion in anaesthesiology . Apr 1, 2021 Anticoagulation strategies in continuous renal replacement therapy. Legrand M, Tolwani A Seminars in dialysis . Mar 8, 2021 Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock. Moins-Teisserenc H, Cordeiro DJ, Audigier V, Ressaire Q, Benyamina M, Lambert J, Maki G, Homyrda L, Toubert A, Legrand M Frontiers in immunology . Mar 2, 2021 Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J Critical Care Medicine . Mar 1, 2021 Complications in Patients With COVID-19. Legrand M JAMA cardiology . Mar 1, 2021 Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study. Blet A, Deniau B, Santos K, van Lier DPT, Azibani F, Wittebole X, Chousterman BG, Gayat E, Hartmann O, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, Mebazaa A, AdrenOSS-1 Study Investigators Critical care (London, England) . Feb 15, 2021 Assessing the importance of interleukin-6 in COVID-19 - Authors' reply. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroianni F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS The Lancet. Respiratory medicine . Jan 15, 2021 Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers? Joffre J, Legrand M Annals of intensive care . Jan 6, 2021 Goal-directed therapy and development of acute kidney injury. Joosten A, Alexander B, Duranteau J, Legrand M European journal of anaesthesiology . Jan 1, 2021 Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains. Legrand M, Liu K Critical Care Medicine . Dec 1, 2020 Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA Nature reviews. Nephrology . Dec 1, 2020 The A2B trial, antibiotic prophylaxis for excision-graft surgery in burn patients: a multicenter randomized double-blind study. Dépret F, Farny B, Jeanne M, Klouche K, Leclerc T, Nouette-Gaulain K, Pantet O, Rémerand F, Roquilly A, Rousseau AF, Sztajnic S, Wiramus S, Vicaut E, Legrand M, A2B trial investigators Trials . Nov 25, 2020 Choice of fluid for critically ill patients: An overview of specific situations. Joannes-Boyau O, Roquilly A, Constantin JM, Duracher-Gout C, Dahyot-Fizelier C, Langeron O, Legrand M, Mirek S, Mongardon N, Mrozek S, Muller L, Orban JC, Virat A, Leone M, Critical Care Committee of the French Society of Anaesthesia and Intensive Care (SFAR) Anaesthesia, critical care & pain medicine . Oct 19, 2020 Response of US hospitals to elective surgical cases in the COVID-19 pandemic. Pirracchio R, Mavrothalassitis O, Mathis M, Kheterpal S, Legrand M British journal of anaesthesia . Oct 19, 2020 Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS The Lancet. Respiratory medicine . Oct 16, 2020 COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA Nature reviews. Nephrology . Oct 15, 2020 Incidence and Outcome of Subclinical Acute Kidney Injury Using penKid in Critically Ill Patients. Dépret F, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Leone M, Guidet B, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Struck J, Hartmann O, Mebazaa A, Gayat E, Legrand M American journal of respiratory and critical care medicine . Sep 15, 2020 Cardiovascular Consequences of Acute Kidney Injury. Reply. Legrand M, Rossignol P The New England journal of medicine . Sep 10, 2020 Insulin glucose infusion versus nebulised salbutamol versus combination of salbutamol and insulin glucose in acute hyperkalaemia in the emergency room: protocol for a randomised, multicentre, controlled study (INSAKA). Montassier E, Lemoine L, Hardouin JB, Rossignol P, Legrand M BMJ open . Aug 26, 2020 Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department. Abensur Vuillaume L, Ferreira JP, Asseray N, Trombert-Paviot B, Montassier E, Legrand M, Girerd N, Boivin JM, Chouihed T, Rossignol P PloS one . Aug 4, 2020 Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Khorashadi M, Beunders R, Pickkers P, Legrand M Nephron . Jul 31, 2020 Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G Anaesthesia, critical care & pain medicine . Jul 23, 2020 Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G Annals of intensive care . Jul 22, 2020 Practical management of worsening renal function in outpatients with heart failure and reduced ejection fraction: Statement from a panel of multidisciplinary experts and the Heart Failure Working Group of the French Society of Cardiology. Mewton N, Girerd N, Boffa JJ, Courivaud C, Isnard R, Juillard L, Lamblin N, Legrand M, Logeart D, Mariat C, Meune E, Sabouret P, Sebbag L, Rossignol P Archives of cardiovascular diseases . Jul 11, 2020 The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Legrand M, Oufella HA, De Backer D, Duranteau J, Leone M, Levy B, Rossignol P, Vicaut E, Dépret F, I-MICRO trial investigators Trials . Jul 1, 2020 Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19. Dudoignon E, Moreno N, Deniau B, Coutrot M, Longer R, Amiot Q, Mebazaa A, Pirracchio R, Depret F, Legrand M Anaesthesia, critical care & pain medicine . Jun 18, 2020 Cardiovascular Consequences of Acute Kidney Injury. Legrand M, Rossignol P The New England journal of medicine . Jun 4, 2020 Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Meert AP, Borcoman E, Bisbal M, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L Critical Care Medicine . Jun 1, 2020 Outcome and characteristics of invasive fungal infections in critically ill burn patients: A multicenter retrospective study. Maurel V, Denis B, Camby M, Jeanne M, Cornesse A, Glavnik B, Alanio A, Rousseau AF, Lefloch R, Lagrange-Xelot M, Textoris J, Wiramus S, de Tymowski C, Legrand M Mycoses . May 10, 2020 Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J Journal of immunology (Baltimore, Md. : 1950) . May 8, 2020 Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Leisman DE, Deutschman CS, Legrand M Intensive care medicine . Apr 28, 2020 Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients. Dépret F, Amzallag J, Pollina A, Fayolle-Pivot L, Coutrot M, Chaussard M, Santos K, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Benyamina M, Guillemet L, Deniau B, Mebazaa A, Gayat E, Farny B, Textoris J, Legrand M, PRONOBURN group Critical care (London, England) . Apr 22, 2020 Point-of-care serum kalemia measurement accuracy. Depret F, Bonnart Latry D, Gayat E, Plaisance P, Legrand M European journal of emergency medicine : official journal of the European Society for Emergency Medicine . Apr 1, 2020 Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial. Maurel V, Legrand M, Bourgeois E, Masse AL, Bergeron A, Binakdane F, Ntahe A, Legouge M, Vicaut E, Plaud B European journal of anaesthesiology . Apr 1, 2020 Should we ban hydroethyl starches from the operating theatre? PRO. Legrand M, Pirracchio R Anaesthesia, critical care & pain medicine . Mar 14, 2020 Management of severe thermal burns in the acute phase in adults and children. Legrand M, Barraud D, Constant I, Devauchelle P, Donat N, Fontaine M, Goffinet L, Hoffmann C, Jeanne M, Jonqueres J, Leclerc T, Lefort H, Louvet N, Losser MR, Lucas C, Pantet O, Roquilly A, Rousseau AF, Soussi S, Wiramus S, Gayat E, Blet A Anaesthesia, critical care & pain medicine . Mar 5, 2020 Utility of anaerobic bottles for the diagnosis of bloodstream infections. Lafaurie M, d'Anglejan E, Donay JL, Glotz D, Sarfati E, Mimoun M, Legrand M, Oksenhendler E, Bagot M, Valade S, Bercot B, Molina JM BMC infectious diseases . Feb 14, 2020 Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Khorashadi M, Bokoch MP, Legrand M Annals of intensive care . Feb 12, 2020 Physiological response to fluid resuscitation with Ringer lactate versus Plasmalyte in critically ill burn patients. Chaussard M, Dépret F, Saint-Aubin O, Benyamina M, Coutrot M, Jully M, Oueslati H, Fratani A, Cupaciu A, Poniard A, Asehnoune K, Dimby SF, Mebazaa A, Houze P, Legrand M Journal of applied physiology (Bethesda, Md. : 1985) . Feb 6, 2020 Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits? Legrand M, Alexander B, Joosten A Intensive care medicine . Jan 29, 2020 PenKid measurement at admission is associated with outcome in severely ill burn patients. Dépret F, Polina A, Amzallag J, Fayolle-Pivot L, Coutrot M, Chaussard M, Struck J, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Soussi S, Benyamina M, Guillemet L, Mebazaa A, Textoris J, Legrand M, PRONOBURN group Burns : journal of the International Society for Burn Injuries . Jan 25, 2020 Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergová Pavkova M, Jarkovský J, Spinar J, Tomandlova M, Dastych M, Ince C, Helanova K, Tesak M, Helan M, Lokaj P, Legrand M, GREAT Network Cardiorenal medicine . Jan 20, 2020 Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, Barbier F, Constantin JM, Clavier T, du Cheyron D, Terzi N, Sauneuf B, Guerot E, Lafon T, Herbland A, Megarbane B, Leclerc T, Mallet V, Pirracchio R, Legrand M Critical care (London, England) . Dec 23, 2019 Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section. Ostermann M, Schneider A, Rimmele T, Bobek I, van Dam M, Darmon M, Forni L, Joannes-Boyau O, Joannidis M, Legrand M, Prowle J, Zarbock A, Hoste E Intensive care medicine experimental . Dec 7, 2019 One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study. Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Launay JM, Ishihara S, Sato N, Mebazaa A, Gayat E, French and euRopean Outcome reGistry in ICUs (FROG-ICU) Investigators Critical Care Medicine . Dec 1, 2019 Tailoring treatment of hyperkalemia. Coutrot M, Dépret F, Legrand M Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . Dec 1, 2019 Untitled Publication Lefort H, Legrand M Revue de l'infirmiere . Dec 1, 2019 The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy. Legrand M, Prowle JR, Forni LG Intensive care medicine . Nov 20, 2019 Monitoring tissue perfusion: a pilot clinical feasibility and safety study of a urethral photoplethysmography-derived perfusion device in high-risk patients. Dépret F, Leone M, Duclos G, Futier E, Montagne M, Legrand M, Allaouchiche B Journal of clinical monitoring and computing . Nov 6, 2019 Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery. Redant S, Legrand M, Langman Y, Aguilar AG, Angoulvant F, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM Critical care (London, England) . Nov 4, 2019 Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway. Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F, Launay JM, Kane B, Kinugasa S, Prakoura N, Vandermeersch S, Cohen-Solal A, Delcayre C, Samuel JL, Mehta R, Gayat E, Mebazaa A, Chadjichristos CE, Legrand M JACC. Basic to translational science . Oct 28, 2019 Urgent need for a randomized controlled trial with only septic patients! Redant S, Legrand M, Langman Y, Garcia Aguilar A, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM Annals of intensive care . Oct 21, 2019 Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study. de Tymowski C, Pallado S, Anstey J, Depret F, Moreno N, Benyamina M, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Chaussard M, Guillemet L, Dudoignon E, Mimoun M, Chaouat M, Mebazaa A, Legrand M, Soussi S, PRONOBURN group Burns : journal of the International Society for Burn Injuries . Oct 16, 2019 Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B Anaesthesia, critical care & pain medicine . Oct 10, 2019 Reply to: "Potential role of ketamine in burn-associated cholestasis". Legrand M, de Tymowski C, Hodjat K, Mallet V Journal of hepatology . Sep 30, 2019 Correction to: Recruiting the microcirculation in septic shock. Legrand M, De Backer D, Dépret F, Ait-Oufella H Annals of intensive care . Sep 24, 2019 Management of Burns. Legrand M, Dépret F, Mallet V The New England journal of medicine . Sep 19, 2019 Recruiting the microcirculation in septic shock. Legrand M, De Backer D, Dépret F, Ait-Oufella H Annals of intensive care . Sep 11, 2019 Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle. Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N Scientific reports . Aug 27, 2019 Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B, TRAUMABASE Group Intensive care medicine . Aug 15, 2019 Understanding the renal response to brain injury. Legrand M, Sonneville R Intensive care medicine . Jul 11, 2019 Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments. Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E The Journal of emergency medicine . Jul 1, 2019 Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU. Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M, FROG-ICU investigators European journal of trauma and emergency surgery : official publication of the European Trauma Society . Jun 18, 2019 Is Nitric Oxide Nephro- or Cardioprotective? Coutrot M, Dépret F, Legrand M American journal of respiratory and critical care medicine . Jun 1, 2019 Contributing factors and outcomes of burn-associated cholestasis. de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M, PRONOBURN group Journal of hepatology . May 30, 2019 Acute Kidney Injury Related to Sepsis-Reply. Legrand M, Kellum JA JAMA . May 14, 2019 Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa. Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A, on behalf the ATB PK/PD study group European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology . May 9, 2019 Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M JAMA network open . May 3, 2019 Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings? Dudoignon E, Dépret F, Legrand M Nephron . Apr 18, 2019 Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial). Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E, STOP-OR-NOT study investigators Trials . Mar 5, 2019 Management of hyperkalemia in the acutely ill patient. Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M Annals of intensive care . Feb 28, 2019 Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive c Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C, BLUE-CarbA study group. BMJ open . Feb 19, 2019 Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study. Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, Legrand M, PRONOBURN group Shock (Augusta, Ga.) . Feb 1, 2019 Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn. Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J Frontiers in immunology . Jan 8, 2019 Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, AdrenOSS-1 study investigators Critical care (London, England) . Dec 21, 2018 Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study. Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S, PRONOBURN group Mycoses . Dec 18, 2018 Serum Creatinine in the Critically Ill Patient With Sepsis. Legrand M, Kellum JA JAMA . Dec 11, 2018 Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases . Dec 6, 2018 Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis. Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M American journal of infection control . Nov 29, 2018 Hydroxocobalamin as a Cause of Oxalate Nephropathy. Legrand M Kidney international reports . Oct 26, 2018 French intensive care unit organisation. Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X Anaesthesia, critical care & pain medicine . Oct 25, 2018 CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit? Schetz M, Legrand M Anaesthesia, critical care & pain medicine . Oct 19, 2018 Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol. Montassier E, Legrand M, Rossignol P, Potel G The American journal of emergency medicine . Oct 16, 2018 Prediction of major adverse kidney events in critically ill burn patients. Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group Burns : journal of the International Society for Burn Injuries . Oct 12, 2018 Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D Intensive care medicine . Oct 5, 2018 Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients. Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S Burns : journal of the International Society for Burn Injuries . Sep 29, 2018 Negative trials in critical care medicine and the hurdles. Legrand M The Lancet. Respiratory medicine . Sep 26, 2018 Early Hemodynamic Management of Critically Ill Burn Patients. Soussi S, Dépret F, Benyamina M, Legrand M Anesthesiology . Sep 1, 2018 New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A International journal of cardiology . Sep 1, 2018 Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis. Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals . Aug 23, 2018 Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study. Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M Kidney international reports . Aug 22, 2018 Hemodynamic management of critically ill burn patients: an international survey. Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M, ESICM Burn ICU working group Critical care (London, England) . Aug 17, 2018 Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X Anaesthesia, critical care & pain medicine . Aug 1, 2018 Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone. Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K Journal of burn care & research : official publication of the American Burn Association . Jun 13, 2018 When ethics collides with a legal gap in emergency life-threatening conditions. Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B British journal of anaesthesia . May 25, 2018 Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury. Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M, FROG-ICU investigators Intensive care medicine . May 15, 2018 Could resuscitation be based on microcirculation data? Yes. Legrand M, Ait-Oufella H, Ince C Intensive care medicine . May 7, 2018 Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A mBio . Apr 24, 2018 Cardiac output and CVP monitoring… to guide fluid removal. Legrand M, Soussi S, Depret F Critical care (London, England) . Apr 12, 2018 Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M, PRONOBURN group Anaesthesia, critical care & pain medicine . Feb 15, 2018 Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge. Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T, AzuRéa Group Critical Care Medicine . Feb 1, 2018 Tolvaptan in Later-Stage Polycystic Kidney Disease. De Tymowski C, Legrand M The New England journal of medicine . Feb 1, 2018 Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report. Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M, FROG ICU study investigators Critical care (London, England) . Jan 29, 2018 Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A Critical care (London, England) . Jan 18, 2018 Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable? Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M, PRONOBURN study group Shock (Augusta, Ga.) . Nov 1, 2017 Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, Plaisance P, Spinar J, Kosiborod M, Mebazaa A, Gayat E, GREAT (Global Research on Acute Conditions Team) Network and INI-CRCT (Investigation Network Initiat Clinical research in cardiology : official journal of the German Cardiac Society . Oct 28, 2017 Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms. Serror K, Chaouat M, Legrand MM, Depret F, Haddad J, Malca N, Mimoun M, Boccara D Burns : journal of the International Society for Burn Injuries . Oct 19, 2017 Pressure guided surgery of compartment syndrome of the limbs in burn patients. Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K Annals of burns and fire disasters . Sep 30, 2017 Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients. Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M, PRONOBURN group Critical care (London, England) . Sep 26, 2017 Intravenous iloprost to recruit the microcirculation in septic shock patients? Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M Intensive care medicine . Sep 18, 2017 Intravenous hydroxocobalamin and crystal nephropathy. Legrand M, Mallet V Nature reviews. Nephrology . Jul 31, 2017 Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit. Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM The Journal of hospital infection . Jul 25, 2017 On-line plasma lactate concentration monitoring in critically ill patients. De Tymowski C, Soussi S, Depret F, Legrand M Critical care (London, England) . Jun 16, 2017 A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Dépret F, Prud'homme M, Legrand M Nephron . Jun 7, 2017 Are capillary and arterial lactates interchangeable? Dépret F, Legrand M Anaesthesia, critical care & pain medicine . Jun 1, 2017 Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Harjola VP, Mullens W, Banaszewski M, Bauersachs J, Brunner-La Rocca HP, Chioncel O, Collins SP, Doehner W, Filippatos GS, Flammer AJ, Fuhrmann V, Lainscak M, Lassus J, Legrand M, Masip J, Mueller C, Papp Z, Parissis J, Platz E, Rudiger A, Ruschitzka F, Schäfer A, Seferovic PM, Skouri H, Yilmaz MB, Mebazaa A European journal of heart failure . May 30, 2017 Imbalanced Angiogenesis in Peripartum Cardiomyopathy - Diagnostic Value of Placenta Growth Factor. Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, Sadoune M, Sarb J, Arrigo M, Motiejunaite J, Laribi S, Legrand M, Deschamps L, Fazal L, Bouadma L, Collet C, Manivet P, Solal AC, Launay JM, Samuel JL, Sliwa K Circulation journal : official journal of the Japanese Circulation Society . May 27, 2017 A nephrologist should be consulted in all cases of acute kidney injury in the ICU: We are not sure. Schetz M, Legrand M Intensive care medicine . May 22, 2017 Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference. Bellomo R, Ronco C, Mehta RL, Asfar P, Boisramé-Helms J, Darmon M, Diehl JL, Duranteau J, Hoste EAJ, Olivier JB, Legrand M, Lerolle N, Malbrain MLNG, Mårtensson J, Oudemans-van Straaten HM, Parienti JJ, Payen D, Perinel S, Peters E, Pickkers P, Rondeau E, Schetz M, Vinsonneau C, Wendon J, Zhang L, Laterre PF Annals of intensive care . May 4, 2017 Diagnostic work-up and specific causes of acute kidney injury. Darmon M, Ostermann M, Cerda J, Dimopoulos MA, Forni L, Hoste E, Legrand M, Lerolle N, Rondeau E, Schneider A, Souweine B, Schetz M Intensive care medicine . Apr 25, 2017 Infectious Complications and Immune/Inflammatory Response in Cardiogenic Shock Patients: A Prospective Observational Study. Parenica J, Jarkovsky J, Malaska J, Mebazaa A, Gottwaldova J, Helanova K, Litzman J, Dastych M, Tomandl J, Spinar J, Dostalova L, Lokaj P, Tomandlova M, Pavkova MG, Sevcik P, Legrand M, GREAT Network Shock (Augusta, Ga.) . Feb 1, 2017 Empiric use of hydroxocobalamin in patients with smoke inhlation injury: Not so fast! Legrand M, Michel T Burns : journal of the International Society for Burn Injuries . Jan 3, 2017 Hemodynamic coherence in patients with burns. Soussi S, Legrand M Best practice & research. Clinical anaesthesiology . Nov 1, 2016 Not all β-lactams are equal regarding neurotoxicity. Chaïbi K, Chaussard M, Soussi S, Lafaurie M, Legrand M Critical care (London, England) . Oct 27, 2016 Should we apply "early" initiation of renal replacement therapy to critically ill patients with acute kidney injury? Legrand M Journal of thoracic disease . Oct 1, 2016 Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future. Rossignol P, Legrand M, Kosiborod M, Hollenberg SM, Peacock WF, Emmett M, Epstein M, Kovesdy CP, Yilmaz MB, Stough WG, Gayat E, Pitt B, Zannad F, Mebazaa A Pharmacological research . Sep 29, 2016 Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M Annals of intensive care . Sep 15, 2016 Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study. Soussi S, Deniau B, Ferry A, Levé C, Benyamina M, Maurel V, Chaussard M, Le Cam B, Blet A, Mimoun M, Lambert J, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group Annals of intensive care . Sep 13, 2016 Understanding the kidney during acute respiratory failure. Darmon M, Legrand M, Terzi N Intensive care medicine . Sep 12, 2016 Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment. Legrand M, Gits-Muselli M, Boutin L, Garcia-Hermoso D, Maurel V, Soussi S, Benyamina M, Ferry A, Chaussard M, Hamane S, Denis B, Touratier S, Guigue N, Fréalle E, Jeanne M, Shaal JV, Soler C, Mimoun M, Chaouat M, Lafaurie M, Mebazaa A, Bretagne S, Alanio A Clinical infectious diseases : an official publication of the Infectious Diseases Society of America . Aug 17, 2016 Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M, PRONOBURN Group Intensive care medicine . Aug 9, 2016 Chloride toxicity in critically ill patients: What's the evidence? Soussi S, Ferry A, Chaussard M, Legrand M Anaesthesia, critical care & pain medicine . Jul 28, 2016 Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A Clinical research in cardiology : official journal of the German Cardiac Society . Jun 17, 2016 What's new in focused assessment with sonography: ballistic trauma. Legrand M, Russell R Intensive care medicine . Jun 11, 2016 Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study. Legrand M, Le Cam B, Perbet S, Roger C, Darmon M, Guerci P, Ferry A, Maurel V, Soussi S, Constantin JM, Gayat E, Lefrant JY, Leone M, support of the AZUREA network Critical care (London, England) . May 29, 2016 Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar), Société de réanimation de langue française (SRLF), Groupe francophone de réanimation et urgences pédiatriques (GFRUP), Société française de néphrologie (SFN) Annals of intensive care . May 27, 2016 Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar), Société de réanimation de langue française (SRLF), Groupe francophone de réanimation et urgences pédiatriques (GFRUP), Société française de néphrologie (SFN) Anaesthesia, critical care & pain medicine . May 24, 2016 Heart rate variability and cardiac baroreflex inhibition-derived index predicts pain perception in burn patients. Papaioannou V, Chouvarda I, Gaertner E, Benyamina M, Ferry A, Maurel V, Soussi S, Blet A, Chaouat M, Plaud B, Mebazaa A, Legrand M, PRONOBURN Group Burns : journal of the International Society for Burn Injuries . May 8, 2016 Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure. Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC Journal of intensive care . Mar 31, 2016 Use of Prophylactic Antibiotics in Mechanically Ventilated Patients With Burn Injuries. Legrand M, Lafaurie M Clinical infectious diseases : an official publication of the Infectious Diseases Society of America . Mar 6, 2016 Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients. Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A, PRONOBURN Study Group Intensive care medicine . Feb 18, 2016 The new Sfar journals are in place. Plaud B, Lefrant JY, Editorial Board, Anaesthesia Critical Care & Pain Medicine Anaesthesia, critical care & pain medicine . Feb 1, 2016 Intravenous Fluids in AKI: A Mechanistically Guided Approach. Legrand M, Ince C Seminars in nephrology . Jan 1, 2016 Renal replacement therapy in adult and pediatric intensive care : Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emerge Vinsonneau C, Allain-Launay E, Blayau C, Darmon M, Ducheyron D, Gaillot T, Honore PM, Javouhey E, Krummel T, Lahoche A, Letacon S, Legrand M, Monchi M, Ridel C, Robert R, Schortgen F, Souweine B, Vaillant P, Velly L, Osman D, Van Vong L Annals of intensive care . Dec 30, 2015 Cross-talk phenomenon during femoral transpulmonary thermodilution in a critically ill patient. Soussi S, Ferry A, Bahaji M, De Tymowski C, Legrand M Anaesthesia, critical care & pain medicine . Dec 5, 2015 Influence of the central venous site on the transpulmonary thermodilution parameters in critically ill burn patients. Soussi S, Sisso F, Maurel V, Oueslati H, Legrand M Burns : journal of the International Society for Burn Injuries . Jul 20, 2015 Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Kamel T, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY Intensive care medicine . May 1, 2015 Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis. Ressaire Q, Padoin C, Chaouat M, Maurel V, Alanio A, Ferry A, Soussi S, Benyamina M, Denis B, Mimoun M, Mebazaa A, Legrand M Intensive care medicine . Mar 24, 2015 Fenoldopam and acute kidney injury. Legrand M, Darmon M, Joannidis M JAMA . Mar 3, 2015 Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Toufik K, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY Intensive care medicine . Mar 3, 2015 Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL, Global Research on Acute Conditions Team (GREAT) Clinical chemistry and laboratory medicine . Mar 1, 2015 Erratum to: Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D Intensive care medicine . Feb 1, 2015 Ten tips for managing critically ill burn patients: follow the RASTAFARI! Legrand M, Guttormsen AB, Berger MM Intensive care medicine . Jan 9, 2015 Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D Intensive care medicine . Dec 3, 2014 Biomarkers for AKI improve clinical practice: yes. Legrand M, Darmon M Intensive care medicine . Nov 12, 2014 Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL, Global Research on Acute Conditions Team (GREAT) PloS one . Nov 11, 2014 Reply: To PMID 24667613. Legrand M, Payen D, Vallée F, Mateo J Shock (Augusta, Ga.) . Sep 1, 2014 When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome. Legrand M, Mebazaa A, Ronco C, Januzzi JL Critical Care Medicine . Sep 1, 2014 Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, Lewington A Blood purification . Jul 3, 2014 Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2! Legrand M, Vallée F, Mateo J, Payen D Shock (Augusta, Ga.) . Jun 1, 2014 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Papaioannou V, Mebazaa A, Plaud B, Legrand M Intensive care medicine experimental . May 14, 2014 In reply. Legrand M, Payen D Anesthesiology . Jan 1, 2014 Etomidate and general anesthesia: the butterfly effect? Legrand M, Plaud B Anesthesia and analgesia . Dec 1, 2013 Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, Payen D Critical care (London, England) . Nov 29, 2013 Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. Legrand M, Pirracchio R, Rosa A, Petersen ML, Van der Laan M, Fabiani JN, Fernandez-gerlinger MP, Podglajen I, Safran D, Cholley B, Mainardi JL Critical care (London, England) . Oct 4, 2013 Novelties in biomarkers for the management of circulatory failure. Legrand M, Gayat E Current opinion in critical care . Oct 1, 2013 NGAL and AKI: the end of a myth? Legrand M, Darmon M, Joannidis M Intensive care medicine . Aug 16, 2013 Critical research on biomarkers: what's new? Legrand M, Januzzi JL, Mebazaa A Intensive care medicine . Jul 5, 2013 Case scenario: Hemodynamic management of postoperative acute kidney injury. Legrand M, Payen D Anesthesiology . Jun 1, 2013 The elusive task of biomarkers of renal injury. Legrand M, Mari A, Mebazaa A Critical care (London, England) . Apr 17, 2013 Transcranial Doppler monitoring may be misleading in prediction of elevated ICP in brain-injured patients. Ahmad M, Legrand M, Lukaszewicz AC, Charlier P, Mateo J, Payen D Intensive care medicine . Mar 20, 2013 Accuracy of urine NGAL commercial assays in critically ill patients. Legrand M, Collet C, Gayat E, Henao J, Giraudeaux V, Mateo J, Launay JM, Payen D Intensive care medicine . Dec 15, 2012 Management of renal replacement therapy in ICU patients: an international survey. Legrand M, Darmon M, Joannidis M, Payen D Intensive care medicine . Sep 22, 2012 Diagnostic accuracy of insulin-like growth factor binding protein-1 for amniotic fluid embolism*. Legrand M, Rossignol M, Dreux S, Luton D, Ventré C, Barranger E, Laribi S, Payen D, Muller F Critical Care Medicine . Jul 1, 2012 A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype. Payen D, Lukaszewicz AC, Legrand M, Gayat E, Faivre V, Megarbane B, Azoulay E, Fieux F, Charron D, Loiseau P, Busson M PloS one . Jun 6, 2012 Survival in neutropenic patients with severe sepsis or septic shock. Legrand M, Max A, Peigne V, Mariotte E, Canet E, Debrumetz A, Lemiale V, Seguin A, Darmon M, Schlemmer B, Azoulay E Critical Care Medicine . Jan 1, 2012 Can we identify prerenal physiology and does it matter? Payen D, Legrand M Contributions to nephrology . Sep 9, 2011 Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats. Legrand M, Kandil A, Payen D, Ince C Journal of cardiovascular pharmacology . Aug 1, 2011 The use of dabigatran in elderly patients. Legrand M, Mateo J, Aribaud A, Ginisty S, Eftekhari P, Huy PT, Drouet L, Payen D Archives of internal medicine . Jul 25, 2011 Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C Shock (Augusta, Ga.) . Jul 1, 2011 The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Legrand M, Bezemer R, Kandil A, Demirci C, Payen D, Ince C Intensive care medicine . Jun 22, 2011 The strategy of antibiotic use in critically ill neutropenic patients. Legrand M, Max A, Schlemmer B, Azoulay E, Gachot B Annals of intensive care . Jun 15, 2011 Arterial catheter-related bloodstream infections: results of an 8-year survey in a surgical intensive care unit. Pirracchio R, Legrand M, Rigon MR, Mateo J, Lukaszewicz AC, Mebazaa A, Raskine L, Le Pors MJ, Payen D Critical Care Medicine . Jun 1, 2011 Understanding urine output in critically ill patients. Legrand M, Payen D Annals of intensive care . May 24, 2011 Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms. Bezemer R, Faber DJ, Almac E, Kalkman J, Legrand M, Heger M, Ince C Medical & biological engineering & computing . Nov 3, 2010 Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. Bezemer R, Legrand M, Klijn E, Heger M, Post IC, van Gulik TM, Payen D, Ince C Optics express . Jul 5, 2010 Intensity of continuous renal-replacement therapy. Legrand M, Payen D The New England journal of medicine . Feb 4, 2010 Echocardiography in hemodynamic monitoring. Chimot L, Legrand M, Canet E, Lemiale V, Azoulay E Chest . Feb 1, 2010 The response of the host microcirculation to bacterial sepsis: does the pathogen matter? Legrand M, Klijn E, Payen D, Ince C Journal of molecular medicine (Berlin, Germany) . Jan 30, 2010 Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Legrand M, Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C Anesthesiology . Jan 1, 2010 The role of the microcirculation in acute kidney injury. Le Dorze M, Legrand M, Payen D, Ince C Current opinion in critical care . Dec 1, 2009 Microcirculation and mitochondria in sepsis: getting out of breath. Balestra GM, Legrand M, Ince C Current opinion in anaesthesiology . Apr 1, 2009 L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Legrand M, Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C American journal of physiology. Renal physiology . Feb 18, 2009 Paediatric intracranial empyema: differences according to age. Legrand M, Roujeau T, Meyer P, Carli P, Orliaguet G, Blanot S European journal of pediatrics . Jan 10, 2009 Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Legrand M, Mik EG, Johannes T, Payen D, Ince C Molecular medicine (Cambridge, Mass.) . Jul 1, 2008 Pleural drain malposition. Legrand M, Lecuyer L, Van De Louw A, Thierry S Intensive care medicine . Mar 24, 2006 Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J Anesthesiology . Jun 1, 2005
