Matthieu Legrand, MD, PhD

Professor in Residence
What I do: 

As a practicing intensivist and anesthesiologist, I care for severally ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting the long-term consequences of acute critical illnesses. My professional interests include diagnosing and optimum treatments of cardiovascular failure, the diagnosis, pathophysiology, and treatment of acute kidney injury and metabolic disorders, applied physiology, and bedside medical education. My research interests have been focusing on the development and validation of several biomarkers, mostly in the setting of sepsis and diagnostic biomarkers of Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. We have investigated factors associated with poor outcomes in severely ill burn patients, with a particular interest in hemodynamic factors, the occurrence of Acute Kidney Injury, and sepsis. I have also investigated the pathophysiology of Acute Kidney Injury and the microcirculation role in kidney damage. Over the last years, I have explored why patients with AKI have a poor outcome despite supportive care. We have reported, with others, that AKI can trigger inflammation and fibrosis pathways in the heart. We are investigating the use of vasodilators to rescue the microcirculation in sepsis. Furthermore, we reported that cardiovascular treatments such as Angiotensin system blockers were associated with better long-term outcomes after AKI. We are now investigating the impact of modulating the renin-angiotensin system on outcomes after Acute Kidney Injury and the Impact of withholding inhibitors of the renin-angiotensin system before major surgery in multicenter Randomized controlled trials.  

Biography: 

Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012.
Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital.

As a clinical-scientist practicing critical care medicine and anesthesiology, I care for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting the long-term consequences of acute critical illnesses. My professional interests include diagnosing and optimum treatments of cardiovascular failure, the diagnosis, pathophysiology, and treatment of acute kidney injury and metabolic disorders, applied physiology, and bedside medical education. My research interests have been focusing on the development and validation of several biomarkers, mostly in the setting of sepsis and diagnostic biomarkers of Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. We have investigated factors associated with poor outcomes in severely ill burn patients, with a particular interest in hemodynamic factors, the occurrence of Acute Kidney Injury, and sepsis. I have also investigated the pathophysiology of Acute Kidney Injury and the microcirculation role in kidney damage. We are investigating the use of vaso-active agents - from vasopressors to vaso dilators - to improve outcomes in surgical and critically ill patients. We are also how modulating the renin-angiotensin system impacts outcomes after major surgery or after Acute Kidney Injury .

Publications: 
Legrand M, Liu KD. Kidney Replacement Therapy in the ICU: Less Is More (Death)? Am J Kidney Dis. 2021 Oct; 78(4):614-616.
Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021 Jul 05.
Chiu C, Legrand M. Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol. 2021 Apr 01; 34(2):71-76.
Legrand M, Tolwani A. Anticoagulation strategies in continuous renal replacement therapy. Semin Dial. 2021 Mar 08.
Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 03 01; 49(3):e315-e326.
Legrand M. Complications in Patients With COVID-19. JAMA Cardiol. 2021 03 01; 6(3):359.
Joffre J, Legrand M. Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers? Ann Intensive Care. 2021 Jan 06; 11(1):1.
Joosten A, Alexander B, Duranteau J, Legrand M. Goal-directed therapy and development of acute kidney injury. Eur J Anaesthesiol. 2021 01; 38(1):96-97.
Legrand M, Liu K. Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains. Crit Care Med. 2020 12; 48(12):1922-1923.
Pirracchio R, Mavrothalassitis O, Mathis M, Kheterpal S, Legrand M. Response of US hospitals to elective surgical cases in the COVID-19 pandemic. Br J Anaesth. 2021 01; 126(1):e46-e48.
Legrand M, Rossignol P. Cardiovascular Consequences of Acute Kidney Injury. Reply. N Engl J Med. 2020 09 10; 383(11):1094.
Khorashadi M, Beunders R, Pickkers P, Legrand M. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Nephron. 2020; 144(12):655-661.
Legrand M, Oufella HA, De Backer D, Duranteau J, Leone M, Levy B, Rossignol P, Vicaut E, Dépret F, I-MICRO trial investigators . The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Trials. 2020 Jul 01; 21(1):601.
Legrand M, Rossignol P. Cardiovascular Consequences of Acute Kidney Injury. N Engl J Med. 2020 06 04; 382(23):2238-2247.
Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Meert AP, Borcoman E, Bisbal M, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L. Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. Crit Care Med. 2020 06; 48(6):822-829.
Maurel V, Denis B, Camby M, Jeanne M, Cornesse A, Glavnik B, Alanio A, Rousseau AF, Lefloch R, Lagrange-Xelot M, Textoris J, Wiramus S, de Tymowski C, Legrand M. Outcome and characteristics of invasive fungal infections in critically ill burn patients: A multicenter retrospective study. Mycoses. 2020 Jun; 63(6):535-542.
Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 06 15; 204(12):3339-3350.
Leisman DE, Deutschman CS, Legrand M. Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med. 2020 06; 46(6):1105-1108.
Dépret F, Amzallag J, Pollina A, Fayolle-Pivot L, Coutrot M, Chaussard M, Santos K, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Benyamina M, Guillemet L, Deniau B, Mebazaa A, Gayat E, Farny B, Textoris J, Legrand M, PRONOBURN group . Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients. Crit Care. 2020 04 22; 24(1):168.
Depret F, Bonnart Latry D, Gayat E, Plaisance P, Legrand M. Point-of-care serum kalemia measurement accuracy. Eur J Emerg Med. 2020 04; 27(2):150-151.
Maurel V, Legrand M, Bourgeois E, Masse AL, Bergeron A, Binakdane F, Ntahe A, Legouge M, Vicaut E, Plaud B. Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial. Eur J Anaesthesiol. 2020 04; 37(4):333-334.
Legrand M, Pirracchio R. Should we ban hydroethyl starches from the operating theatre? PRO. Anaesth Crit Care Pain Med. 2020 Apr; 39(2):187-188.
Legrand M, Barraud D, Constant I, Devauchelle P, Donat N, Fontaine M, Goffinet L, Hoffmann C, Jeanne M, Jonqueres J, Leclerc T, Lefort H, Louvet N, Losser MR, Lucas C, Pantet O, Roquilly A, Rousseau AF, Soussi S, Wiramus S, Gayat E, Blet A. Management of severe thermal burns in the acute phase in adults and children. Anaesth Crit Care Pain Med. 2020 04; 39(2):253-267.
Lafaurie M, d'Anglejan E, Donay JL, Glotz D, Sarfati E, Mimoun M, Legrand M, Oksenhendler E, Bagot M, Valade S, Bercot B, Molina JM. Utility of anaerobic bottles for the diagnosis of bloodstream infections. BMC Infect Dis. 2020 Feb 14; 20(1):142.
Khorashadi M, Bokoch MP, Legrand M. Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Ann Intensive Care. 2020 Feb 12; 10(1):22.
Chaussard M, Dépret F, Saint-Aubin O, Benyamina M, Coutrot M, Jully M, Oueslati H, Fratani A, Cupaciu A, Poniard A, Asehnoune K, Dimby SF, Mebazaa A, Houze P, Legrand M. Physiological response to fluid resuscitation with Ringer lactate versus Plasmalyte in critically ill burn patients. J Appl Physiol (1985). 2020 03 01; 128(3):709-714.
Legrand M, Alexander B, Joosten A. Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits? Intensive Care Med. 2020 03; 46(3):552-553.
Dépret F, Polina A, Amzallag J, Fayolle-Pivot L, Coutrot M, Chaussard M, Struck J, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Soussi S, Benyamina M, Guillemet L, Mebazaa A, Textoris J, Legrand M, PRONOBURN group . PenKid measurement at admission is associated with outcome in severely ill burn patients. Burns. 2020 09; 46(6):1302-1309.
Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergová Pavkova M, Jarkovský J, Spinar J, Tomandlova M, Dastych M, Ince C, Helanova K, Tesak M, Helan M, Lokaj P, Legrand M, GREAT Network . Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. Cardiorenal Med. 2020; 10(2):85-96.
Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, Barbier F, Constantin JM, Clavier T, du Cheyron D, Terzi N, Sauneuf B, Guerot E, Lafon T, Herbland A, Megarbane B, Leclerc T, Mallet V, Pirracchio R, Legrand M. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019 Dec 23; 23(1):421.
Ostermann M, Schneider A, Rimmele T, Bobek I, van Dam M, Darmon M, Forni L, Joannes-Boyau O, Joannidis M, Legrand M, Prowle J, Zarbock A, Hoste E. Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section. Intensive Care Med Exp. 2019 Dec 07; 7(1):69.
Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Launay JM, Ishihara S, Sato N, Mebazaa A, Gayat E, French and euRopean Outcome reGistry in ICUs (FROG-ICU) Investigators . One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study. Crit Care Med. 2019 12; 47(12):e953-e961.
Coutrot M, Dépret F, Legrand M. Tailoring treatment of hyperkalemia. Nephrol Dial Transplant. 2019 12 01; 34(Suppl 3):iii62-iii68.
Lefort H, Legrand M. Rev Infirm. 2019 Dec; 68(256):17.
Legrand M, Prowle JR, Forni LG. The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy. Intensive Care Med. 2020 03; 46(3):510-512.
Dépret F, Leone M, Duclos G, Futier E, Montagne M, Legrand M, Allaouchiche B. Monitoring tissue perfusion: a pilot clinical feasibility and safety study of a urethral photoplethysmography-derived perfusion device in high-risk patients. J Clin Monit Comput. 2020 Oct; 34(5):961-969.
Redant S, Legrand M, Langman Y, Aguilar AG, Angoulvant F, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM. Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery. Crit Care. 2019 11 04; 23(1):343.
Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F, Launay JM, Kane B, Kinugasa S, Prakoura N, Vandermeersch S, Cohen-Solal A, Delcayre C, Samuel JL, Mehta R, Gayat E, Mebazaa A, Chadjichristos CE, Legrand M. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway. JACC Basic Transl Sci. 2019 Oct; 4(6):717-732.
Redant S, Legrand M, Langman Y, Garcia Aguilar A, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM. Urgent need for a randomized controlled trial with only septic patients! Ann Intensive Care. 2019 Oct 21; 9(1):121.
de Tymowski C, Pallado S, Anstey J, Depret F, Moreno N, Benyamina M, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Chaussard M, Guillemet L, Dudoignon E, Mimoun M, Chaouat M, Mebazaa A, Legrand M, Soussi S, PRONOBURN group . Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study. Burns. 2020 05; 46(3):630-638.
Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B. Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Anaesth Crit Care Pain Med. 2019 12; 38(6):647-656.
Legrand M, de Tymowski C, Hodjat K, Mallet V. Reply to: "Potential role of ketamine in burn-associated cholestasis". J Hepatol. 2019 12; 71(6):1276-1277.
Legrand M, De Backer D, Dépret F, Ait-Oufella H. Correction to: Recruiting the microcirculation in septic shock. Ann Intensive Care. 2019 Sep 24; 9(1):107.
Legrand M, Dépret F, Mallet V. Management of Burns. N Engl J Med. 2019 09 19; 381(12):1188-1189.
Legrand M, De Backer D, Dépret F, Ait-Oufella H. Recruiting the microcirculation in septic shock. Ann Intensive Care. 2019 Sep 11; 9(1):102.
Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N. Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle. Sci Rep. 2019 08 27; 9(1):12378.
Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B, TRAUMABASE Group . Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Intensive Care Med. 2019 09; 45(9):1231-1240.
Legrand M, Sonneville R. Understanding the renal response to brain injury. Intensive Care Med. 2019 08; 45(8):1112-1115.
Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E. Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments. J Emerg Med. 2019 07; 57(1):102-103.
Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M, FROG-ICU investigators . Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU. Eur J Trauma Emerg Surg. 2021 Apr; 47(2):461-466.
Coutrot M, Dépret F, Legrand M. Is Nitric Oxide Nephro- or Cardioprotective? Am J Respir Crit Care Med. 2019 06 01; 199(11):1441-1442.
de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M, PRONOBURN group . Contributing factors and outcomes of burn-associated cholestasis. J Hepatol. 2019 09; 71(3):563-572.
Legrand M, Kellum JA. Acute Kidney Injury Related to Sepsis-Reply. JAMA. 2019 05 14; 321(18):1828-1829.
Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A, on behalf the ATB PK/PD study group . Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis. 2019 Aug; 38(8):1457-1461.
Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M. Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. JAMA Netw Open. 2019 05 03; 2(5):e193215.
Dudoignon E, Dépret F, Legrand M. Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings? Nephron. 2019; 143(3):179-183.
Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E, STOP-OR-NOT study investigators . Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial). Trials. 2019 Mar 05; 20(1):160.
Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M. Management of hyperkalemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28; 9(1):32.
Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C, BLUE-CarbA study group. . Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol. BMJ Open. 2019 02 19; 9(2):e024561.
Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, Legrand M, PRONOBURN group . Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study. Shock. 2019 02; 51(2):153-160.
Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J. Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn. Front Immunol. 2018; 9:3091.
Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, AdrenOSS-1 study investigators . Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Crit Care. 2018 12 21; 22(1):354.
Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S, PRONOBURN group . Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study. Mycoses. 2019 Mar; 62(3):237-246.
Legrand M, Kellum JA. Serum Creatinine in the Critically Ill Patient With Sepsis. JAMA. 2018 Dec 11; 320(22):2369-2370.
Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. Int J Infect Dis. 2019 Feb; 79:179-184.
Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M. Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis. Am J Infect Control. 2019 04; 47(4):435-438.
Legrand M. Hydroxocobalamin as a Cause of Oxalate Nephropathy. Kidney Int Rep. 2019 Jan; 4(1):185.
Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X. French intensive care unit organisation. Anaesth Crit Care Pain Med. 2018 12; 37(6):625-627.
Schetz M, Legrand M. CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit? Anaesth Crit Care Pain Med. 2018 12; 37(6):519-520.
Montassier E, Legrand M, Rossignol P, Potel G. Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol. Am J Emerg Med. 2019 05; 37(5):1004.
Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group . Prediction of major adverse kidney events in critically ill burn patients. Burns. 2018 12; 44(8):1887-1894.
Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D. Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Intensive Care Med. 2018 Nov; 44(11):1904-1913.
Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S. Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients. Burns. 2018 12; 44(8):2106-2107.
Legrand M. Negative trials in critical care medicine and the hurdles. Lancet Respir Med. 2018 10; 6(10):e53.
Soussi S, Dépret F, Benyamina M, Legrand M. Early Hemodynamic Management of Critically Ill Burn Patients. Anesthesiology. 2018 Sep; 129(3):583-589.
Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A. New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Int J Cardiol. 2018 Sep 01; 266:95-99.
Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E. Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis. Biomarkers. 2018 Dec; 23(8):766-772.
Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M. Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study. Kidney Int Rep. 2018 11; 3(6):1424-1433.
Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M, ESICM Burn ICU working group . Hemodynamic management of critically ill burn patients: an international survey. Crit Care. 2018 08 17; 22(1):194.
Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X. Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Anaesth Crit Care Pain Med. 2018 08; 37(4):299-301.
Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K. Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone. J Burn Care Res. 2018 06 13; 39(4):580-584.
Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B. When ethics collides with a legal gap in emergency life-threatening conditions. Br J Anaesth. 2018 Aug; 121(2):513-514.
Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M, FROG-ICU investigators . Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury. Intensive Care Med. 2018 May; 44(5):598-605.
Legrand M, Ait-Oufella H, Ince C. Could resuscitation be based on microcirculation data? Yes. Intensive Care Med. 2018 Jun; 44(6):944-946.
Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A. Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. mBio. 2018 04 24; 9(2).
Legrand M, Soussi S, Depret F. Cardiac output and CVP monitoring… to guide fluid removal. Crit Care. 2018 04 12; 22(1):89.
Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M, PRONOBURN group . Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Anaesth Crit Care Pain Med. 2018 12; 37(6):551-556.
Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T, AzuRéa Group . Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge. Crit Care Med. 2018 02; 46(2):e102-e110.
De Tymowski C, Legrand M. Tolvaptan in Later-Stage Polycystic Kidney Disease. N Engl J Med. 2018 02 01; 378(5):488.
Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M, FROG ICU study investigators . Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report. Crit Care. 2018 01 29; 22(1):24.
Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Crit Care. 2018 01 18; 22(1):8.
Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M, PRONOBURN study group . Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable? Shock. 2017 11; 48(5):532-538.
Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, Plaisance P, Spinar J, Kosiborod M, Mebazaa A, Gayat E, GREAT (Global Research on Acute Conditions Team) Network and INI-CRCT (Investigation Network Initiat . Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Clin Res Cardiol. 2018 Mar; 107(3):214-221.
Serror K, Chaouat M, Legrand MM, Depret F, Haddad J, Malca N, Mimoun M, Boccara D. Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms. Burns. 2018 May; 44(3):544-548.
Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K. Pressure guided surgery of compartment syndrome of the limbs in burn patients. Ann Burns Fire Disasters. 2017 Sep 30; 30(3):193-197.
Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M, PRONOBURN group . Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients. Crit Care. 2017 Sep 26; 21(1):245.
Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M. Intravenous iloprost to recruit the microcirculation in septic shock patients? Intensive Care Med. 2018 01; 44(1):121-122.
Legrand M, Mallet V. Intravenous hydroxocobalamin and crystal nephropathy. Nat Rev Nephrol. 2017 09; 13(9):593.
Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit. J Hosp Infect. 2017 Nov; 97(3):226-233.
De Tymowski C, Soussi S, Depret F, Legrand M. On-line plasma lactate concentration monitoring in critically ill patients. Crit Care. 2017 06 16; 21(1):151.
Dépret F, Prud'homme M, Legrand M. A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Nephron. 2017; 137(4):273-276.
Dépret F, Legrand M. Are capillary and arterial lactates interchangeable? Anaesth Crit Care Pain Med. 2017 06; 36(3):149.
Harjola VP, Mullens W, Banaszewski M, Bauersachs J, Brunner-La Rocca HP, Chioncel O, Collins SP, Doehner W, Filippatos GS, Flammer AJ, Fuhrmann V, Lainscak M, Lassus J, Legrand M, Masip J, Mueller C, Papp Z, Parissis J, Platz E, Rudiger A, Ruschitzka F, Schäfer A, Seferovic PM, Skouri H, Yilmaz MB, Mebazaa A. Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail. 2017 07; 19(7):821-836.
Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, Sadoune M, Sarb J, Arrigo M, Motiejunaite J, Laribi S, Legrand M, Deschamps L, Fazal L, Bouadma L, Collet C, Manivet P, Solal AC, Launay JM, Samuel JL, Sliwa K. Imbalanced Angiogenesis in Peripartum Cardiomyopathy - Diagnostic Value of Placenta Growth Factor. Circ J. 2017 Oct 25; 81(11):1654-1661.
Schetz M, Legrand M. A nephrologist should be consulted in all cases of acute kidney injury in the ICU: We are not sure. Intensive Care Med. 2017 06; 43(6):880-882.
Bellomo R, Ronco C, Mehta RL, Asfar P, Boisramé-Helms J, Darmon M, Diehl JL, Duranteau J, Hoste EAJ, Olivier JB, Legrand M, Lerolle N, Malbrain MLNG, Mårtensson J, Oudemans-van Straaten HM, Parienti JJ, Payen D, Perinel S, Peters E, Pickkers P, Rondeau E, Schetz M, Vinsonneau C, Wendon J, Zhang L, Laterre PF. Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference. Ann Intensive Care. 2017 Dec; 7(1):49.
Darmon M, Ostermann M, Cerda J, Dimopoulos MA, Forni L, Hoste E, Legrand M, Lerolle N, Rondeau E, Schneider A, Souweine B, Schetz M. Diagnostic work-up and specific causes of acute kidney injury. Intensive Care Med. 2017 Jun; 43(6):829-840.
Parenica J, Jarkovsky J, Malaska J, Mebazaa A, Gottwaldova J, Helanova K, Litzman J, Dastych M, Tomandl J, Spinar J, Dostalova L, Lokaj P, Tomandlova M, Pavkova MG, Sevcik P, Legrand M, GREAT Network . Infectious Complications and Immune/Inflammatory Response in Cardiogenic Shock Patients: A Prospective Observational Study. Shock. 2017 02; 47(2):165-174.
Legrand M, Michel T. Empiric use of hydroxocobalamin in patients with smoke inhlation injury: Not so fast! Burns. 2017 06; 43(4):886.
Chaïbi K, Chaussard M, Soussi S, Lafaurie M, Legrand M. Not all β-lactams are equal regarding neurotoxicity. Crit Care. 2016 10 27; 20(1):350.
Legrand M. Should we apply "early" initiation of renal replacement therapy to critically ill patients with acute kidney injury? J Thorac Dis. 2016 Oct; 8(10):E1271-E1273.
Rossignol P, Legrand M, Kosiborod M, Hollenberg SM, Peacock WF, Emmett M, Epstein M, Kovesdy CP, Yilmaz MB, Stough WG, Gayat E, Pitt B, Zannad F, Mebazaa A. Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future. Pharmacol Res. 2016 11; 113(Pt A):585-591.
Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF). Ann Intensive Care. 2016 Dec; 6(1):90.
Soussi S, Deniau B, Ferry A, Levé C, Benyamina M, Maurel V, Chaussard M, Le Cam B, Blet A, Mimoun M, Lambert J, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group . Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study. Ann Intensive Care. 2016 Dec; 6(1):87.
Darmon M, Legrand M, Terzi N. Understanding the kidney during acute respiratory failure. Intensive Care Med. 2017 08; 43(8):1144-1147.
Legrand M, Gits-Muselli M, Boutin L, Garcia-Hermoso D, Maurel V, Soussi S, Benyamina M, Ferry A, Chaussard M, Hamane S, Denis B, Touratier S, Guigue N, Fréalle E, Jeanne M, Shaal JV, Soler C, Mimoun M, Chaouat M, Lafaurie M, Mebazaa A, Bretagne S, Alanio A. Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment. Clin Infect Dis. 2016 Nov 15; 63(10):1312-1317.
Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M, PRONOBURN Group . Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Intensive Care Med. 2016 Nov; 42(11):1826-1827.
Soussi S, Ferry A, Chaussard M, Legrand M. Chloride toxicity in critically ill patients: What's the evidence? Anaesth Crit Care Pain Med. 2017 Apr; 36(2):125-130.
Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Clin Res Cardiol. 2016 Dec; 105(12):971-980.
Legrand M, Russell R. What's new in focused assessment with sonography: ballistic trauma. Intensive Care Med. 2016 Nov; 42(11):1787-1789.
Legrand M, Le Cam B, Perbet S, Roger C, Darmon M, Guerci P, Ferry A, Maurel V, Soussi S, Constantin JM, Gayat E, Lefrant JY, Leone M, support of the AZUREA network . Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study. Crit Care. 2016 May 29; 20(1):165.
Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar) , Société de réanimation de langue française (SRLF) , Groupe francophone de réanimation et urgences pédiatriques (GFRUP) , Société française de néphrologie (SFN) . Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ann Intensive Care. 2016 Dec; 6(1):48.
Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L, Société française d’anesthésie et de réanimation (Sfar) , Société de réanimation de langue française (SRLF) , Groupe francophone de réanimation et urgences pédiatriques (GFRUP) , Société française de néphrologie (SFN) . Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Anaesth Crit Care Pain Med. 2016 Apr; 35(2):151-65.
Papaioannou V, Chouvarda I, Gaertner E, Benyamina M, Ferry A, Maurel V, Soussi S, Blet A, Chaouat M, Plaud B, Mebazaa A, Legrand M, PRONOBURN Group . Heart rate variability and cardiac baroreflex inhibition-derived index predicts pain perception in burn patients. Burns. 2016 Nov; 42(7):1445-1454.
Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC. Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure. J Intensive Care. 2016; 4:24.
Legrand M, Lafaurie M. Use of Prophylactic Antibiotics in Mechanically Ventilated Patients With Burn Injuries. Clin Infect Dis. 2016 06 01; 62(11):1464-5.
Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A, PRONOBURN Study Group . Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients. Intensive Care Med. 2016 Jun; 42(6):1080-1.
Plaud B, Lefrant JY, Editorial Board, Anaesthesia Critical Care & Pain Medicine . The new Sfar journals are in place. Anaesth Crit Care Pain Med. 2016 Feb; 35(1):1-2.
Legrand M, Ince C. Intravenous Fluids in AKI: A Mechanistically Guided Approach. Semin Nephrol. 2016 Jan; 36(1):53-61.
Vinsonneau C, Allain-Launay E, Blayau C, Darmon M, Ducheyron D, Gaillot T, Honore PM, Javouhey E, Krummel T, Lahoche A, Letacon S, Legrand M, Monchi M, Ridel C, Robert R, Schortgen F, Souweine B, Vaillant P, Velly L, Osman D, Van Vong L. Renal replacement therapy in adult and pediatric intensive care : Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emergencies (GFRUP) the French Dialysis Society (SFD). Ann Intensive Care. 2015 Dec; 5(1):58.
Soussi S, Ferry A, Bahaji M, De Tymowski C, Legrand M. Cross-talk phenomenon during femoral transpulmonary thermodilution in a critically ill patient. Anaesth Crit Care Pain Med. 2016 Feb; 35(1):69-70.
Soussi S, Sisso F, Maurel V, Oueslati H, Legrand M. Influence of the central venous site on the transpulmonary thermodilution parameters in critically ill burn patients. Burns. 2015 Nov; 41(7):1607-10.
Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Kamel T, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY. Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 May; 41(5):966-8.
Ressaire Q, Padoin C, Chaouat M, Maurel V, Alanio A, Ferry A, Soussi S, Benyamina M, Denis B, Mimoun M, Mebazaa A, Legrand M. Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis. Intensive Care Med. 2015 May; 41(5):948-9.
Legrand M, Darmon M, Joannidis M. Fenoldopam and acute kidney injury. JAMA. 2015 Mar 03; 313(9):970-1.
Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Toufik K, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY. Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 Apr; 41(4):667-76.
De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL, Global Research on Acute Conditions Team (GREAT) . Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. Clin Chem Lab Med. 2015 Mar; 53(4):613-21.
Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D. Erratum to: Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med. 2015 Feb; 41(2):386.
Legrand M, Guttormsen AB, Berger MM. Ten tips for managing critically ill burn patients: follow the RASTAFARI! Intensive Care Med. 2015 Jun; 41(6):1107-9.
Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D. Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med. 2015 Jan; 41(1):68-76.
Legrand M, Darmon M. Biomarkers for AKI improve clinical practice: yes. Intensive Care Med. 2015 Apr; 41(4):615-7.
Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL, Global Research on Acute Conditions Team (GREAT) . Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. PLoS One. 2014; 9(11):e112313.
Legrand M, Payen D, Vallée F, Mateo J. Reply: To PMID 24667613. Shock. 2014 Sep; 42(3):279-80.
Legrand M, Mebazaa A, Ronco C, Januzzi JL. When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome. Crit Care Med. 2014 Sep; 42(9):2109-17.
Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, Lewington A. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Blood Purif. 2014; 37(4):271-85.
Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR. An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard. Clin Imaging. 2014 Sep-Oct; 38(5):693-7.
Legrand M, Vallée F, Mateo J, Payen D. Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2! Shock. 2014 Jun; 41(6):510-3.
Papaioannou V, Mebazaa A, Plaud B, Legrand M. 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Intensive Care Med Exp. 2014 Dec; 2(1):18.
Legrand M, Payen D. In reply. Anesthesiology. 2014 Jan; 120(1):244-5.
Legrand M, Plaud B. Etomidate and general anesthesia: the butterfly effect? Anesth Analg. 2013 Dec; 117(6):1267-9.
Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, Payen D. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care. 2013 Nov 29; 17(6):R278.
Legrand M, Pirracchio R, Rosa A, Petersen ML, Van der Laan M, Fabiani JN, Fernandez-gerlinger MP, Podglajen I, Safran D, Cholley B, Mainardi JL. Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. Crit Care. 2013 Oct 04; 17(5):R220.
Legrand M, Gayat E. Novelties in biomarkers for the management of circulatory failure. Curr Opin Crit Care. 2013 Oct; 19(5):410-6.
Legrand M, Darmon M, Joannidis M. NGAL and AKI: the end of a myth? Intensive Care Med. 2013 Oct; 39(10):1861-3.
Legrand M, Januzzi JL, Mebazaa A. Critical research on biomarkers: what's new? Intensive Care Med. 2013 Oct; 39(10):1824-8.