Matthias Behrends, MD

HS Clinical Professor

Dr. Matthias Behrends is an anesthesiologist who joined UCSF in 2004. In his research, he focuses on optimizing treatment strategies in regional anesthesia (nerve blocks, or injections that numb pain in a certain part of the body).

Behrends earned his medical degree from the University of G?ttingen. He trained in anesthesiology at the University of Duisburg-Essen. He also spent three years as a postdoctoral scholar in the pathophysiology department at the University of Duisburg-Essen, investigating myocardial hibernation and ischemic preconditioning.

Bongiovanni T, Lancaster E, Behrends M, Zhang L, Wick E, Auerbach A, Pletcher MJ. Optimizing Uptake of Multimodal Pain Management After Surgery Using the Electronic Health Record. JAMA Surg. 2023 Oct 01; 158(10):1108-1111.
Bongiovanni T, Pletcher MJ, Lau C, Robinson A, Lancaster E, Zhang L, Behrends M, Wick E, Auerbach A. A behavioral intervention to promote use of multimodal pain medication for hospitalized patients: A randomized controlled trial. J Hosp Med. 2023 08; 18(8):685-692.
Azimaraghi O, Bilal M, Amornyotin S, Arain M, Behrends M, Berzin TM, Buxbaum JL, Choice C, Fassbender P, Sawhney MS, Sundar E, Wongtangman K, Leslie K, Eikermann M. Consensus guidelines for the perioperative management of patients undergoing endoscopic retrograde cholangiopancreatography. Br J Anaesth. 2023 06; 130(6):763-772.
Buren MA, Theologis A, Zuraek A, Behrends M, Clark AJ, Leung JM. Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial. BMJ Open. 2022 06 06; 12(6):e059416.
Yap E, Wei J, Webb C, Ng K, Behrends M. Neuraxial and general anesthesia for outpatient total joint arthroplasty result in similarly low rates of major perioperative complications: a multicentered cohort study. Reg Anesth Pain Med. 2022 05; 47(5):294-300.
Harbell MW, Kolodzie K, Behrends M, Ma CB, Kinjo S, Yap E, Braehler MR, Aleshi P. Extraplexus versus intraplexus ultrasound-guided interscalene brachial plexus block for ambulatory arthroscopic shoulder surgery: A randomized controlled trial. PLoS One. 2021; 16(2):e0246792.
Yap EN, Behrends M. Editorial Commentary: Neuraxial Anesthesia Improves Pain After Hip Arthroscopy but Risks Ambulatory Discharge Delay. Arthroscopy. 2021 01; 37(1):147-148.
Sharp AL, Gilbert S, Perez DN, Kolodzie K, Behrends M. Perioperative outcomes for patients on chronic buprenorphine undergoing spine surgery: A case series. J Opioid Manag. 2021; 17(7):171-177.
Su PP, Peniche A, Clelland E, Ladd M, Delgado A, Chen LL, Siegmueller C, Latronica M, Naidu R, Aleshi P, Behrends M. Comparison of programmed intermittent epidural bolus and continuous epidural infusion for post-operative analgesia after major abdominal surgery: A randomized controlled trial. J Clin Anesth. 2020 Apr 28; 64:109850.
Groeben H, Walz MK, Nottebaum BJ, Alesina PF, Greenwald A, Schumann R, Hollmann MW, Schwarte L, Behrends M, Rössel T, Groeben C, Schäfer M, Lowery A, Hirata N, Yamakage M, Miller JA, Cherry TJ, Nelson A, Solorzano CC, Gigliotti B, Wang TS, Wietasch JKG, Friederich P, Sheppard B, Graham PH, Weingarten TN, Sprung J. International multicentre review of perioperative management and outcome for catecholamine-producing tumours. Br J Surg. 2020 01; 107(2):e170-e178.
Rajan J, Behrends M. Acute Pain in Older Adults: Recommendations for Assessment and Treatment. Anesthesiol Clin. 2019 Sep; 37(3):507-520.
Behrends M, Yap EN, Zhang AL, Kolodzie K, Kinjo S, Harbell MW, Aleshi P. Preoperative Fascia Iliaca Block Does Not Improve Analgesia after Arthroscopic Hip Surgery, but Causes Quadriceps Muscles Weakness: A Randomized, Double-blind Trial. Anesthesiology. 2018 09; 129(3):536-543.
Behrends M, Larson MD, Neice AE, Bokoch MP. Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2019 Apr; 33(2):317-323.
Neice AE, Larson MD, Behrends M, Bokoch MP. In Response. Anesth Analg. 2017 08; 125(2):694-695.
Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Anesth Analg. 2017 03; 124(3):915-921.
Harbell MW, Cohen JM, Kolodzie K, Behrends M, Braehler MR, Kinjo S, Feeley BT, Aleshi P. Combined preoperative femoral and sciatic nerve blockade improves analgesia after anterior cruciate ligament reconstruction: a randomized controlled clinical trial. J Clin Anesth. 2016 Sep; 33:68-74.
Larson MD, Behrends M. Portable infrared pupillometry: a review. Anesth Analg. 2015 Jun; 120(6):1242-53.
Elizabeth L. Whitlock, Matthias Behrends. Blood Transfusion and Postoperative Delirium. Current Anesthesiology Reports. 2015 Mar 1; 5(1):24-32.
Bokoch MP, Behrends M, Neice A, Larson MD. Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May; 189:68-74.
Behrends M, DePalma G, Sands L, Leung J. Association between intraoperative blood transfusions and early postoperative delirium in older adults. J Am Geriatr Soc. 2013 Mar; 61(3):365-70.
Behrends M, Niemann CU, Larson MD. Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series. Resuscitation. 2012 Oct; 83(10):1223-8.
Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU. Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. J Gastroenterol. 2010 Nov; 45(11):1103-10.
Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ. Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. J Surg Res. 2010 Jan; 158(1):43-52.
Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, Hirose R. Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats. J Gastrointest Surg. 2010 Mar; 14(3):528-35.
Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Anesthesiology. 2008 Mar; 108(3):402-14.
Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU. Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model. Surgery. 2008 Feb; 143(2):243-51.
Brendt P, Behrends M, Peters J. Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. Resuscitation. 2008 Jan; 76(1):95-102.
Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU. Remote renal injury following partial hepatic ischemia/reperfusion injury in rats. J Gastrointest Surg. 2008 Mar; 12(3):490-5.
Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP. Central venous pressure monitoring during living right donor hepatectomy. Liver Transpl. 2007 Feb; 13(2):266-71.
Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU. Ischemia-reperfusion injury is more severe in older versus young rat livers. J Surg Res. 2007 Jan; 137(1):96-102.
Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU. Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Liver Int. 2006 Aug; 26(6):734-41.
Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ. Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery. 2006 Sep; 140(3):404-12.
Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R. Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Transfus Med. 2006 Apr; 16(2):93-100.
Noh J, Behrends M, Choi S, Bedolli MA, Yardi J, Hirose R, Niemann CU. Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats. J Gastrointest Surg. 2006 Feb; 10(2):234-9.
Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Anesth Analg. 2005 Dec; 101(6):1577-1583.
Behrends M, Beiderlinden M, Peters J. Acute lung injury after peppermint oil injection. Anesth Analg. 2005 Oct; 101(4):1160-1162.
Matthias Behrends, Joonhwa Noh, Soojinna Choi, Ryutaro Hirose, Melanie Bedoli, John P. Roberts, Claus U. Niemann. Glutamine does not ameliorate hepatic ischemia/reperfusion injury in rats. Journal of Gastrointestinal Surgery. 2005 Apr 1; 9(4):555.
Matthias Behrends, Ryutaro Hirose, Soojinna Choi, Claus U. Niemann. Normothermia during partial hepatic ischemia increases hepatic injury. Journal of Gastrointestinal Surgery. 2005 Apr 1; 9(4):554-555.
Behrends M, Beiderlinden M, Peters J. Combination of sildenafil and bosentan for nitric oxide withdrawal. Eur J Anaesthesiol. 2005 Feb; 22(2):155-7.
Behrends M, Peters J. The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med. 2003 Oct; 29(10):1802-7.
Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res. 2001 Nov; 52(2):181-98.
Behrends M, Kernbach M, Bräuer A, Braun U, Peters J, Weyland W. In vitro validation of a metabolic monitor for gas exchange measurements in ventilated neonates. Intensive Care Med. 2001 Jan; 27(1):228-35.
Schulz R, Walz MK, Behrends M, Neumann T, Gerken G, Heusch G. Minimal protection of the liver by ischemic preconditioning in pigs. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H198-207.
Dörge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G. Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2587-92.
Behrends M, Walz MK, Kribben A, Neumann T, Helmchen U, Philipp T, Schulz R, Heusch G. No protection of the porcine kidney by ischaemic preconditioning. Exp Physiol. 2000 Nov; 85(6):819-27.
Weidenbach R, Schulz R, Gres P, Behrends M, Post H, Heusch G. Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism. Br J Pharmacol. 2000 Sep; 131(1):138-44.
Behrends M, Schulz R, Post H, Alexandrov A, Belosjorow S, Michel MC, Heusch G. Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1111-9.
Giebler RM, Behrends M, Steffens T, Walz MK, Peitgen K, Peters J. Intraperitoneal and retroperitoneal carbon dioxide insufflation evoke different effects on caval vein pressure gradients in humans: evidence for the starling resistor concept of abdominal venous return. Anesthesiology. 2000 Jun; 92(6):1568-80.
Post H, Schulz R, Behrends M, Gres P, Umschlag C, Heusch G. No involvement of endogenous nitric oxide in classical ischemic preconditioning in swine. J Mol Cell Cardiol. 2000 May; 32(5):725-33.
Dörge H, Behrends M, Schulz R, Jalowy A, Heusch G. Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan. Basic Res Cardiol. 1999 Jun; 94(3):208-14.
Behrends M, Schulz R, Heusch G. Effects of verapamil and mibefradil on regional blood flow and function in normal and ischemic myocardium. Cardiovasc Drugs Ther. 1999 May; 13(3):275-6.
Jalowy A, Schulz R, Dörge H, Behrends M, Heusch G. Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs. J Am Coll Cardiol. 1998 Nov 15; 32(6):1787-96.
R. Giebler, M. Behrends, M. Walz, K. Peitgen, J. Peters. Caval pressure gradients are induced with intraperitoneal but not with retroperitoneal CO2 insufflation during laparoscopic or retroperitoneoscopic surgical procedures in humans. Anesthesiology. 1998 Sep 1; 89(Supplement):284a.