Biography Dr. Matthias Behrends is an anesthesiologist who joined UCSF in 2004. His clinical work involves mostly pain management after surgery with a focus on optimizing treatment strategies with regional anesthesia (nerve blocks, or injections that numb pain in a certain part of the body). He is currently the Medical Director of the UCSF Health Inpatient Pain Services and the Acting Director of the Regional Anesthesia team. In his research, he focuses on clinical trials on how to improve pain after surgery. He also investigates the effects of pain and pain medication on pupil movements using infrared pupillometry. Behrends earned his medical degree from the University of Göttingen. He trained in anesthesiology at the University of Duisburg-Essen. He also spent three years as a postdoctoral scholar in the pathophysiology department at the University of Duisburg-Essen, investigating myocardial hibernation and ischemic preconditioning. Role Faculty Location UCSF at Mission Bay UCSF at Mount Zion UCSF at Parnassus Category Clinical Specialties Global Health Equity Pain Medicine Regional Anesthesia Education Residency, 2003 - Anesthesiology, University of Duisburg-EssenFellowship, 2000 - Pathophysiology, University of Duisburg-Essen1996 - , University of Göttingen Publications Erector Spinae Plane versus Pectoralis Nerve Block for Mastectomy in Cancer Patients: A Retrospective, Multicenter Cohort Study. Yap EN, Wei J, Darling C, Linehan E, Behrends M, Ng KP [Open educational resources for otorhinolaryngology : A pilot study on needs assessment and implementation]. Degen CV, Schwitzing F, Long S, Gickel L, Behrends M, Busch CJ, Steffens S, Mikuteit M The Development and Implementation of the Fast-Pace Assessment Framework and Tiered Analgesic Orders for Opioid Optimization. Bazinski M, Lau C, Clemons B, Purser L, Kangwankij A, Ngo L, Lang M, Besen B, Gross K, Borucki A, Behrends M, Miaskowski C, Schell-Chaple H Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study. Behrends M, Larson MD Electronic health record intervention to increase use of NSAIDs as analgesia for hospitalised patients: a cluster randomised controlled study. Bongiovanni T, Pletcher MJ, Robinson A, Lancaster E, Zhang L, Behrends M, Wick E, Auerbach A Optimizing Uptake of Multimodal Pain Management After Surgery Using the Electronic Health Record. Bongiovanni T, Lancaster E, Behrends M, Zhang L, Wick E, Auerbach A, Pletcher MJ A behavioral intervention to promote use of multimodal pain medication for hospitalized patients: A randomized controlled trial. Bongiovanni T, Pletcher MJ, Lau C, Robinson A, Lancaster E, Zhang L, Behrends M, Wick E, Auerbach A Consensus guidelines for the perioperative management of patients undergoing endoscopic retrograde cholangiopancreatography. Azimaraghi O, Bilal M, Amornyotin S, Arain M, Behrends M, Berzin TM, Buxbaum JL, Choice C, Fassbender P, Sawhney MS, Sundar E, Wongtangman K, Leslie K, Eikermann M Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial. Buren MA, Theologis A, Zuraek A, Behrends M, Clark AJ, Leung JM Neuraxial and general anesthesia for outpatient total joint arthroplasty result in similarly low rates of major perioperative complications: a multicentered cohort study. Yap E, Wei J, Webb C, Ng K, Behrends M Extraplexus versus intraplexus ultrasound-guided interscalene brachial plexus block for ambulatory arthroscopic shoulder surgery: A randomized controlled trial. Harbell MW, Kolodzie K, Behrends M, Ma CB, Kinjo S, Yap E, Braehler MR, Aleshi P Editorial Commentary: Neuraxial Anesthesia Improves Pain After Hip Arthroscopy but Risks Ambulatory Discharge Delay. Yap EN, Behrends M Perioperative outcomes for patients on chronic buprenorphine undergoing spine surgery: A case series. Sharp AL, Gilbert S, Perez DN, Kolodzie K, Behrends M Comparison of programmed intermittent epidural bolus and continuous epidural infusion for post-operative analgesia after major abdominal surgery: A randomized controlled trial. Su PP, Peniche A, Clelland E, Ladd M, Delgado A, Chen LL, Siegmueller C, Latronica M, Naidu R, Aleshi P, Behrends M International multicentre review of perioperative management and outcome for catecholamine-producing tumours. Groeben H, Walz MK, Nottebaum BJ, Alesina PF, Greenwald A, Schumann R, Hollmann MW, Schwarte L, Behrends M, Rössel T, Groeben C, Schäfer M, Lowery A, Hirata N, Yamakage M, Miller JA, Cherry TJ, Nelson A, Solorzano CC, Gigliotti B, Wang TS, Wietasch JKG, Friederich P, Sheppard B, Graham PH, Weingarten TN, Sprung J Acute Pain in Older Adults: Recommendations for Assessment and Treatment. Rajan J, Behrends M Preoperative Fascia Iliaca Block Does Not Improve Analgesia after Arthroscopic Hip Surgery, but Causes Quadriceps Muscles Weakness: A Randomized, Double-blind Trial. Behrends M, Yap EN, Zhang AL, Kolodzie K, Kinjo S, Harbell MW, Aleshi P Suppression of pupillary unrest by general anesthesia and propofol sedation. Behrends M, Larson MD, Neice AE, Bokoch MP In Response. Neice AE, Larson MD, Behrends M, Bokoch MP Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD Combined preoperative femoral and sciatic nerve blockade improves analgesia after anterior cruciate ligament reconstruction: a randomized controlled clinical trial. Harbell MW, Cohen JM, Kolodzie K, Behrends M, Braehler MR, Kinjo S, Feeley BT, Aleshi P Portable infrared pupillometry: a review. Larson MD, Behrends M Blood Transfusion and Postoperative Delirium. Elizabeth L. Whitlock, Matthias Behrends Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Bokoch MP, Behrends M, Neice A, Larson MD Association between intraoperative blood transfusions and early postoperative delirium in older adults. Behrends M, DePalma G, Sands L, Leung J Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series. Behrends M, Niemann CU, Larson MD Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats. Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, Hirose R Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model. Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. Brendt P, Behrends M, Peters J Remote renal injury following partial hepatic ischemia/reperfusion injury in rats. Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU Central venous pressure monitoring during living right donor hepatectomy. Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP Ischemia-reperfusion injury is more severe in older versus young rat livers. Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats. Noh J, Behrends M, Choi S, Bedolli MA, Yardi J, Hirose R, Niemann CU Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N Acute lung injury after peppermint oil injection. Behrends M, Beiderlinden M, Peters J Glutamine does not ameliorate hepatic ischemia/reperfusion injury in rats. Matthias Behrends, Joonhwa Noh, Soojinna Choi, Ryutaro Hirose, Melanie Bedoli, John P. Roberts, Claus U. Niemann Normothermia during partial hepatic ischemia increases hepatic injury. Matthias Behrends, Ryutaro Hirose, Soojinna Choi, Claus U. Niemann Combination of sildenafil and bosentan for nitric oxide withdrawal. Behrends M, Beiderlinden M, Peters J The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Behrends M, Peters J Signal transduction of ischemic preconditioning. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G In vitro validation of a metabolic monitor for gas exchange measurements in ventilated neonates. Behrends M, Kernbach M, Bräuer A, Braun U, Peters J, Weyland W Minimal protection of the liver by ischemic preconditioning in pigs. Schulz R, Walz MK, Behrends M, Neumann T, Gerken G, Heusch G Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation. Dörge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G No protection of the porcine kidney by ischaemic preconditioning. Behrends M, Walz MK, Kribben A, Neumann T, Helmchen U, Philipp T, Schulz R, Heusch G Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism. Weidenbach R, Schulz R, Gres P, Behrends M, Post H, Heusch G Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs. Behrends M, Schulz R, Post H, Alexandrov A, Belosjorow S, Michel MC, Heusch G Intraperitoneal and retroperitoneal carbon dioxide insufflation evoke different effects on caval vein pressure gradients in humans: evidence for the starling resistor concept of abdominal venous return. Giebler RM, Behrends M, Steffens T, Walz MK, Peitgen K, Peters J No involvement of endogenous nitric oxide in classical ischemic preconditioning in swine. Post H, Schulz R, Behrends M, Gres P, Umschlag C, Heusch G Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan. Dörge H, Behrends M, Schulz R, Jalowy A, Heusch G Effects of verapamil and mibefradil on regional blood flow and function in normal and ischemic myocardium. Behrends M, Schulz R, Heusch G Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs. Jalowy A, Schulz R, Dörge H, Behrends M, Heusch G Caval pressure gradients are induced with intraperitoneal but not with retroperitoneal CO2 insufflation during laparoscopic or retroperitoneoscopic surgical procedures in humans. R. Giebler, M. Behrends, M. Walz, K. Peitgen, J. Peters
