Biography Dr. Schumacher is Professor and Vice Chair of Pain Medicine in the Department of Anesthesia and Perioperative Care, University of California, San Francisco. He has a clinical, research and educational focus on pain medicine with an emphasis on the development of evidence – based pain care into general clinical practice that utilize non-addictive modalities to improve both the quality and safety of analgesic care. Dr. Schumacher is also the Director of the UCSF Pain and Addiction Research Center (PARC) and served on the National Academies of Science Engineering and Medicine Committee, co-authoring the report on “Pain Management and the Opioid Epidemic.” Scientifically, following his collaboration in the cloning of the Capsaicin Receptor (TRPV1), he has led a laboratory dedicated to non-addictive strategies to block the transition from acute to chronic pain through transcriptional blockade. His NIH-funded research includes: Study of painful Chemotherapy-Induced Peripheral Neuropathy (CIPN) with the aim to develop novel non-opioid therapeutics and studying Neuro-immune Mechanisms of Analgesia of the Minor Cannabinoids such as CBD and CBN. He is also investigating novel sensory neuron receptors that mediate neuropathic pain. Throughout his career, he has sought ways to integrate the science and practice of pain medicine including previously directing an NIH Center of Excellence in Pain Education at UCSF. Role Faculty Location UCSF at Parnassus Category Clinical Specialties Pain Medicine Education Sabbatical, 2004 - Biophysics Research,, Blackett Laboratory - Imperial College, London UK (Nick Franks, Mervyn Maze)Fellow, 1995 - Pain Research, University of California, San Francisco (David Julius, Jon Levine)Residency, 1993 - Anesthesia, University of California, San FranciscoInternship, 1991 - Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CaliforniaMedicine, 1990 - M.D., University of California, San DiegoFellow, 1990 - Pain Research, University of California, San Diego (Tony Yaksh)Fellow, 1987 - Molecular Pharmacology, University of California, San Diego (Palmer Taylor)Ph.D., 1987 - Physiology & Pharmacology, University of California, San Diego (Palmer Taylor, Theodore Friedmann)B.A, 1979 - Biology, University of California, San Diego Publications Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes. Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ . Pain . Jan 23, 2025 Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes. Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ . bioRxiv : the preprint server for biology . Jul 10, 2024 Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic. Schumacher MA . Current neuropharmacology . Jan 1, 2024 Chemotherapy for pain: reversing inflammatory and neuropathic pain with the anticancer agent mithramycin A. Xu Z, Lee MC, Sheehan K, Fujii K, Rabl K, Rader G, Varney S, Sharma M, Eilers H, Kober K, Miaskowski C, Levine JD, Schumacher MA . Pain . Jun 27, 2023 N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J . Journal of neuroinflammation . May 24, 2022 Occurrence and perceived effectiveness of activities used to decrease chemotherapy-induced peripheral neuropathy symptoms in the feet. Ogle T, Alexander K, Yates P, Paul SM, Kober KM, Conley YP, Schumacher M, Levine JD, Miaskowski C . European journal of oncology nursing : the official journal of European Oncology Nursing Society . Sep 2, 2021 Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014. Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA . Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews . Jan 7, 2020 Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pa Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C . Molecular pain . Jan 1, 2020 AAAPT Diagnostic Criteria for Acute Pain Following Breast Surgery. Schreiber KL, Belfer I, Miaskowski C, Schumacher M, Stacey BR, Van De Ven T . The journal of pain . Sep 5, 2019 Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM . Journal of neuroimmunology . Aug 2, 2019 Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors. Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C . Journal of pain and symptom management . Apr 30, 2019 Transcription factor Sp4 is required for hyperalgesic state persistence. Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M . PloS one . Feb 27, 2019 Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors. Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C . Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer . Feb 15, 2019 Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients. Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD . The Clinical journal of pain . Jan 1, 2019 Pain Management and Opioid Regulation: Continuing Public Health Challenges. Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS . American journal of public health . Jan 1, 2019 Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy. Kober KM, Schumacher M, Conley YP, Topp K, Mazor M, Hammer MJ, Paul SM, Levine JD, Miaskowski C . Molecular pain . Jan 1, 2019 Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors. Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C . Molecular pain . Nov 14, 2018 Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors. Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C . Journal of pain and symptom management . Aug 30, 2018 Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. Peniche A, Poree L, Schumacher M, Yu X . A&A practice . Jun 1, 2018 Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD . Journal of pain and symptom management . Mar 7, 2018 Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life. Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD . Journal of cancer survivorship : research and practice . Nov 20, 2017 Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD . European journal of oncology nursing : the official journal of European Oncology Nursing Society . Nov 7, 2017 America's Opioid Epidemic: Supply and Demand Considerations. Clark DJ, Schumacher MA . Anesthesia and analgesia . Nov 1, 2017 N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K . Journal of immunology (Baltimore, Md. : 1950) . Jul 12, 2017 The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions. Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G . The journal of pain . May 1, 2017 The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions. Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G . Pain medicine (Malden, Mass.) . May 1, 2017 (431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol. K. Kober, J. Mastick, S. Paul, K. Topp, B. Smoot, G. Abrams, L. Chen, Y. Conley, M. Chesney, K. Bolla, G. Mausisa, M. Azor, M. Wong, M. Schumacher, J. Levine, C. Miaskowski . Journal of Pain . Apr 1, 2017 Chemotherapy-Induced Neuropathy in Cancer Survivors. Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD . Journal of pain and symptom management . Jan 4, 2017 Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. Guan Z, Hellman J, Schumacher M . F1000Research . Sep 30, 2016 The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons. Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA . Neuroscience letters . Jan 25, 2014 Topical capsaicin formulations in the management of neuropathic pain. Schumacher M, Pasvankas G . Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques . Jan 1, 2014 Back pain and the mineralocorticoid receptor: is there a connection? Schumacher MA . Anesthesiology . Nov 1, 2012 Pain Management for the Obese Sleep Apnea Patient. Mark A. Schumacher . ICU Director . Mar 1, 2012 Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA . Molecular pain . Jun 6, 2011 Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma. Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA . Journal of pain and symptom management . Feb 9, 2011 Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW . Anesthesiology . Jun 1, 2010 TRPV1 splice variants: structure and function. Schumacher MA, Eilers H . Frontiers in bioscience (Landmark edition) . Jun 1, 2010 Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Schumacher MA . Pain practice : the official journal of World Institute of Pain . Mar 2, 2010 The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation. Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA . Neuroreport . Jul 2, 2007 Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP . The Journal of biological chemistry . Jun 4, 2007 Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. Xue Q, Jong B, Chen T, Schumacher MA . Journal of neurochemistry . Jan 8, 2007 Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA . The European journal of neuroscience . Nov 1, 2004 Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure? Eilers H, Schumacher MA . Molecular interventions . Aug 1, 2004 Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M . Experimental dermatology . Mar 1, 2004 The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA . Genomics . Aug 1, 2001 The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA . Anesthesia and analgesia . Jul 1, 2001 The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat. Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD . Neuroscience letters . Jun 30, 2000 Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. Schumacher MA, Moff I, Sudanagunta SP, Levine JD . The Journal of biological chemistry . Jan 28, 2000 ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS. Mark A. Schumacher, Irene Moff, Jon D. Levine . Anesthesiology . Sep 1, 1998 The capsaicin receptor: a heat-activated ion channel in the pain pathway. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D . Nature . Oct 23, 1997 ATP receptors in sickness, pain and death. Brake A, Schumacher M, Julius D . Chemistry & biology . Apr 1, 1996 Multiple messenger RNA species give rise to the structural diversity in acetylcholinesterase. Schumacher M, Maulet Y, Camp S, Taylor P . The Journal of biological chemistry . Dec 15, 1988 Primary structure of acetylcholinesterase: implications for regulation and function. Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P . Federation proceedings . Dec 1, 1986 Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P . Nature . Jan 1, 1986 Hepatic (Na+,K+)-ATPase: a current view of its structure, function and localization in rat liver as revealed by studies with monoclonal antibodies. Leffert HL, Schenk DB, Hubert JJ, Skelly H, Schumacher M, Ariyasu R, Ellisman M, Koch KS, Keller GA . Hepatology (Baltimore, Md.) . May 1, 1985 Mechanisms of whole blood-induced cerebral arterial contraction. Schumacher MA, Alksne JF . Neurosurgery . Sep 1, 1981
