Biography Overview: SFGH, as the only level 1 trauma hospital for San Francisco, is where the most severely injured trauma patients are treated. As the Director for Trauma Anesthesiology, I am engaged on multiple fronts to improve the individual treatment, systems-based care and the science of acute trauma care. I embrace the critical role of blood product and coagulation management and I have been introducing best practices and new techniques for this at a local and national level. Recognizing that this is a complex endeavor requiring multiple disciplines to work in synergy, I have taken on leadership, investigative and educational roles to fulfill my vision of delivering state of the art, multidisciplinary care to the severely injured patient. Studies: PROPPR -Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as receiving 10 units or more RBCs within the first 24 hours). The goal of PROPPR is to improve the basis on which clinicians make decisions about transfusion protocols for massively bleeding patients. PROPPR is a Resuscitation Outcomes Consortium (ROC) Protocol. ROC is funded by the National Heart, Lung, and Blood Institute (NHLBI), the United States' Department of Defense (DoD) and the Defence Research and Development Canada. PROPPR will be conducted as a Phase III trial at Level I Adult Trauma Centers in North America. Role Faculty Location UCSF at Mission Bay Zuckerberg San Francisco General Hospital Category Clinical Specialties Trauma Education 2019 - Diversity, Equity, and Inclusion Champion Training, University of California Publications Perioperative blood transfusions in hip and knee arthroplasty: a retrospective assessment of combined risk factors. Erben HC, Hess F, Welter J, Graf N, Steurer MP, Neff TA, Zettl R, Dullenkopf A Archives of orthopaedic and trauma surgery . Feb 19, 2021 Placement of TOF-Cuff® on the lower leg for neuromuscular and blood pressure monitoring during anesthetic induction for shoulder surgeries. Dullenkopf A, Horn K, Steurer MP, Hess F, Welter J Journal of anesthesia . Nov 23, 2019 Dimensional Variations of Left-Sided Double-Lumen Endobronchial Tubes. Hegland N, Schnitzler S, Ellensohn J, Steurer MP, Weiss M, Dullenkopf A Anesthesiology research and practice . Sep 24, 2019 Measuring the accuracy of propofol target-controlled infusion (TCI) before and after surgery with major blood loss. Mohler T, Welter J, Steurer M, Neumann L, Zueger M, Kraemer T, Dullenkopf A Journal of clinical monitoring and computing . Jan 22, 2019 propofol-target-controlled-infusion-performance-of-the-schnider-model-in-the-clinical-setting-for-major-surgical-procedures. Luis Neumann, Thomas Mohler, Marc P Steurer, Max Zueger, Thomas Kraemer, Alexander Dullenkopf Clinical Research and Trials . Jan 1, 2019 Viscoelastic Monitoring to Guide the Correction of Perioperative Coagulopathy and Massive Transfusion in Patients with Life-Threatening Hemorrhage. Blaine KP, Steurer MP Anesthesiology clinics . Dec 19, 2018 Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial. Jones AR, Patel RP, Marques MB, Donnelly JP, Griffin RL, Pittet JF, Kerby JD, Stephens SW, DeSantis SM, Hess JR, Wang HE, PROPPR Study Group Annals of emergency medicine . Nov 15, 2018 Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial. Wei S, Gonzalez Rodriguez E, Chang R, Holcomb JB, Kao LS, Wade CE, PROPPR Study Group Journal of the American College of Surgeons . Sep 21, 2018 Endotracheal tube cuff pressure changes during manual cuff pressure control manoeuvres: An in-vitro assessment. Aeppli N, Lindauer B, Steurer MP, Weiss M, Dullenkopf A Acta anaesthesiologica Scandinavica . Aug 21, 2018 Coagulation Monitoring of the Bleeding Trauma Patient. Marc P. Steurer, Michael T. Ganter Essentials of Trauma Anesthesia . Nov 9, 2017 Post-discharge nausea and vomiting after total intravenous anaesthesia and standardised PONV prophylaxis for ambulatory surgery. Bruderer U, Fisler A, Steurer MP, Steurer M, Dullenkopf A Acta anaesthesiologica Scandinavica . Jun 18, 2017 Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism. McCully BH, Connelly CR, Fair KA, Holcomb JB, Fox EE, Wade CE, Bulger EM, Schreiber MA, PROPPR Study Group Journal of the American College of Surgeons . Mar 16, 2017 Factors influencing the level of patients using the internet to gather information before anaesthesia: a single-centre survey of 815 patients in Switzerland : The internet for patient information before anaesthesia. Wieser T, Steurer MP, Steurer M, Dullenkopf A BMC anesthesiology . Mar 8, 2017 Midazolam plasma concentration after anesthesia premedication in clinical routine - an observational study : Midazolam plasma concentration after anesthesia premedication. Steiner C, Steurer MP, Mueller D, Zueger M, Dullenkopf A BMC anesthesiology . Oct 24, 2016 Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study. Undurraga Perl VJ, Leroux B, Cook MR, Watson J, Fair K, Martin DT, Kerby JD, Williams C, Inaba K, Wade CE, Cotton BA, Del Junco DJ, Fox EE, Scalea TM, Tilley BC, Holcomb JB, Schreiber MA, PROPPR Study Group The journal of trauma and acute care surgery . Apr 1, 2016 Damage Control Resuscitation: More Than Just Transfusion Strategies. Catherine Heim, Marc P. Steurer, Karim Brohi Current Anesthesiology Reports . Mar 1, 2016 Postoperative delirium assessed by post anesthesia care unit staff utilizing the Nursing Delirium Screening Scale: a prospective observational study of 1000 patients in a single Swiss institution. Winter A, Steurer MP, Dullenkopf A BMC anesthesiology . Dec 18, 2015 Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial. Novak DJ, Bai Y, Cooke RK, Marques MB, Fontaine MJ, Gottschall JL, Carey PM, Scanlan RM, Fiebig EW, Shulman IA, Nelson JM, Flax S, Duncan V, Daniel-Johnson JA, Callum JL, Holcomb JB, Fox EE, Baraniuk S, Tilley BC, Schreiber MA, Inaba K, Rizoli S, Podbielski JM, Cotton BA, Hess JR, PROPPR Study Group Transfusion . Mar 30, 2015 Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G, PROPPR Study Group JAMA . Feb 3, 2015 Anesthetic management of patients undergoing bariatric surgery: two year experience in a single institution in Switzerland. Lindauer B, Steurer MP, Müller MK, Dullenkopf A BMC anesthesiology . Dec 18, 2014 Trauma and Massive Blood Transfusions. Marc P. Steurer, Michael T. Ganter Current Anesthesiology Reports . Sep 1, 2014 Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation. Baraniuk S, Tilley BC, del Junco DJ, Fox EE, van Belle G, Wade CE, Podbielski JM, Beeler AM, Hess JR, Bulger EM, Schreiber MA, Inaba K, Fabian TC, Kerby JD, Cohen MJ, Miller CN, Rizoli S, Scalea TM, O'Keeffe T, Brasel KJ, Cotton BA, Muskat P, Holcomb JB, PROPPR Study Group Injury . Jun 10, 2014 Late pharmacologic conditioning with volatile anesthetics after cardiac surgery. Steurer MP, Steurer MA, Baulig W, Piegeler T, Schläpfer M, Spahn DR, Falk V, Dreessen P, Theusinger OM, Schmid ER, Schwartz D, Neff TA, Beck-Schimmer B Critical care (London, England) . Oct 14, 2012 Anesthetic-induced improvement of the inflammatory response to one-lung ventilation. De Conno E, Steurer MP, Wittlinger M, Zalunardo MP, Weder W, Schneiter D, Schimmer RC, Klaghofer R, Neff TA, Schmid ER, Spahn DR, Z'graggen BR, Urner M, Beck-Schimmer B Anesthesiology . Jun 1, 2009 The volatile anaesthetic sevoflurane attenuates lipopolysaccharide-induced injury in alveolar macrophages. Steurer M, Schläpfer M, Steurer M, Z'graggen BR, Booy C, Reyes L, Spahn DR, Beck-Schimmer B Clinical and experimental immunology . Nov 20, 2008 Postconditioning with a volatile anaesthetic in alveolar epithelial cells in vitro. Yue T, Roth Z'graggen B, Blumenthal S, Neff SB, Reyes L, Booy C, Steurer M, Spahn DR, Neff TA, Schmid ER, Beck-Schimmer B The European respiratory journal . Sep 26, 2007 Functional, electrophysiologic, and morphometric evaluation of nerve regeneration from coaptation on regenerated nerve fibers: experimental study in rabbits. Beer GM, Burg D, Zehnder A, Seifert B, Steurer M, Grimaldi H, Meyer VE Journal of reconstructive microsurgery . Feb 1, 2004
