Lawrence Litt, PhD, MD

Professor Emeritus


Now an emeritus professor, I am retired from all research, teaching, and clinical activities. Laboratory research was supported by 24 years of NIH funding via R01 GM034767, during which time I was a member of NIH's Neurology A Study Section for 7 years, and then a member of the Surgery, Anesthesiology and Trauma Study Section for 5 years. Publications listed below are from a list of 88 peer-reviewed publications in professional journals, with 21 being as an experimental elementary particle physicist with post-doc and junior faculty appointments at Harvard, Rockefeller University, and Michigan State University, and visiting scientist appointments at the Centre Européenne pour la Recherche Nucléaire (CERN), Brookhaven, and Fermilab. Approximately 40% of my time during my 33 years at the Parnassus Campus was in clinical anesthesia teaching and care in the Moffitt-Long Hospital Operating rooms, with an emphasis on anesthesia for neurological surgery.

Liu J, Segal MR, Kelly MJ, Pelton JG, Kim M, James TL, Litt L. 13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation. Anesthesiology. 2013 Nov; 119(5):1120-36.
Liu J, Sheldon RA, Segal MR, Kelly MJ, Pelton JG, Ferriero DM, James TL, Litt L. 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries. Pediatr Res. 2013 Aug; 74(2):170-9.
Liu J, Litt L, Segal MR, Kelly MJ, Pelton JG, Kim M. Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites. Int J Mol Sci. 2011; 12(10):6469-501.
Thoma MS, Maa J, Schiller NB, Litt L. Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open? J Clin Anesth. 2010 Nov; 22(7):553-6.
Liu J, Litt L, Segal MR, Kelly MJ, Yoshihara HA, James TL. Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia. J Cereb Blood Flow Metab. 2011 Feb; 31(2):547-59.
Logvinova AV, Litt L, Young WL, Lee CZ. Anesthetic concerns in patients with known cerebrovascular insufficiency. Anesthesiol Clin. 2010 Mar; 28(1):1-12.
Liu J, Hirai K, Litt L. Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices. Brain Res. 2008 Oct 31; 1238:230-8.
Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology. 2007 Oct; 107(4):630-40.
Litt L, Li D. Awareness without recall during anesthesia for electroconvulsive therapy. Anesthesiology. 2007 Apr; 106(4):871-2.
Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L. Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab. 2007 Feb; 27(2):304-15.
Fourcade O, Simon MF, Litt L, Samii K, Chap H. Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. Anesth Analg. 2004 Aug; 99(2):393-8, table of contents.
Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L. Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr. 2004 Aug; 36(4):415-9.
Hirai K, Hayashi T, Chan PH, Zeng J, Yang GY, Basus VJ, James TL, Litt L. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain Res Mol Brain Res. 2004 Apr 29; 124(1):51-61.
Lee CZ, Litt L, Hashimoto T, Young WL. Physiologic monitoring and anesthesia considerations in acute ischemic stroke. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 2):S13-9.
Litt L, Hirai K, Basus VJ, James TL. Temperature control of respiring rat brain slices during high field NMR spectroscopy. Brain Res Brain Res Protoc. 2003 Feb; 10(3):191-8.
Skidmore K, Chen J, Litt L. Arterial catheter pressure cable corrosion leading to artifactual diagnosis of hypotension. Anesth Analg. 2002 Nov; 95(5):1192-5, table of contents.
Hirai K, Sugawara T, Chan PH, Basus VJ, James TL, Litt L. Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices. J Neurochem. 2002 Oct; 83(2):309-19.
Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52.
Lampe GH, Donegan JH, Rupp SM, Wauk LZ, Whitendale P, Fouts KE, Rose BM, Litt LL, Rampil IJ, Wilson CB. Nitrous oxide and epinephrine-induced arrhythmias. Anesth Analg. 1990 Dec; 71(6):602-5.
Lampe GH, Wauk LZ, Donegan JH, Pitts LH, Jackler RK, Litt LL, Rampil IJ, Eger EI. Effect on outcome of prolonged exposure of patients to nitrous oxide. Anesth Analg. 1990 Dec; 71(6):586-90.