Kenneth Drasner, MD

Professor Emeritus

Publications: 
Ruan W, French D, Wong A, Drasner K, Wu AH. A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion. Anesthesiology. 2012 Feb; 116(2):334-9.
French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011 Nov; 49(9):801-9.
French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose. Clin Toxicol (Phila). 2011 Apr; 49(4):340-4.
Drasner K. Anesthetic effects on the developing nervous system: if you aren't concerned, you haven't been paying attention. Anesthesiology. 2010 Jul; 113(1):10-2.
Gray AT, Drasner K. Safety of ultrasound-guided regional anesthesia. Anesthesiology. 2010 Jun; 112(6):1538-9.
Neal JM, Bernards CM, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):152-61.
Drasner K. Local anesthetic systemic toxicity: a historical perspective. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):162-6.
Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL. Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):140-4.
Drasner K, Smiley R. Continuous spinal analgesia for labor and delivery: a born-again technique? Anesthesiology. 2008 Feb; 108(2):184-6.
Drasner K. Epidural chloroprocaine-standard of care for postpartum bilateral tubal ligation. Anesth Analg. 2005 Oct; 101(4):1241.
Drasner K. Chloroprocaine spinal anesthesia: back to the future? Anesth Analg. 2005 Feb; 100(2):549-552.
Drasner K. Thoracic epidural anesthesia: asleep at the wheal? Anesth Analg. 2004 Aug; 99(2):578-9.
Taniguchi M, Bollen AW, Drasner K. Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity? Anesthesiology. 2004 Jan; 100(1):85-91.
Kishimoto T, Bollen AW, Drasner K. Comparative spinal neurotoxicity of prilocaine and lidocaine. Anesthesiology. 2002 Nov; 97(5):1250-3.
Drasner K. Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med. 2002 Nov-Dec; 27(6):576-80.
Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001 May; 94(5):876-81.
Drasner K. Low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular but not intrathecal morphine. Anesthesiology. 2001 Feb; 94(2):298-302.
Hashimoto K, Sakura S, Bollen AW, Ciriales R, Drasner K. Comparative toxicity of glucose and lidocaine administered intrathecally in the rat. Reg Anesth Pain Med. 1998 Sep-Oct; 23(5):444-50.
Freedman JM, Li DK, Drasner K, Jaskela MC, Larsen B, Wi S. Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology. 1998 Sep; 89(3):633-41.
Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther. 1998 May; 285(2):413-21.
Chan VW, Garcia J, Al-Kaisy A, Drasner K. A comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia. Reg Anesth Pain Med. 1998 Mar-Apr; 23(2):164-9.
Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, Harms C, Seeberger M, Schneider MC, Drasner K. Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology. 1998 Mar; 88(3):629-33.
Sakura S, Sumi M, Sakaguchi Y, Saito Y, Kosaka Y, Drasner K. The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology. 1997 Oct; 87(4):771-8.
Drasner K. Lidocaine spinal anesthesia: a vanishing therapeutic index? Anesthesiology. 1997 Sep; 87(3):469-72.
Hampl KF, Schneider MC, Pargger H, Gut J, Drewe J, Drasner K. A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine. Anesth Analg. 1996 Nov; 83(5):1051-4.
Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K. Intrathecal catheterization in the rat. Improved technique for morphologic analysis of drug-induced injury. Anesthesiology. 1996 Nov; 85(5):1184-9.
Weitz SR, Drasner K. Spontaneous intracranial hypotension: a series. Anesthesiology. 1996 Oct; 85(4):923-5.
Sakura S, Drasner K. [Neurologic sequelae of spinal anesthesia: local anesthetic toxicity]. Masui. 1996 Jul; 45(7):846-51.
Sakura S, Bollen AW, Ciriales R, Drasner K. Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg. 1995 Aug; 81(2):338-46.
Weitz SR, Drasner K. Local anesthetic test dose as a predictor of effective epidural opioid analgesia. Anesthesiology. 1995 Jul; 83(1):96-100.
Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33.
Sakura S, Chan VW, Ciriales R, Drasner K. The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat. Anesthesiology. 1995 Jan; 82(1):236-40.
Drasner K, Sakura S, Chan VW, Bollen AW, Ciriales R. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology. 1994 Apr; 80(4):847-52.
Drasner K. Models for local anesthetic toxicity from continuous spinal anesthesia. Reg Anesth. 1993 Nov-Dec; 18(6 Suppl):434-8.
Drasner K, Rigler ML, Sessler DI, Stoller ML. Cauda equina syndrome following intended epidural anesthesia. Anesthesiology. 1992 Sep; 77(3):582-5.
Rigler ML, Drasner K. Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology. 1991 Oct; 75(4):684-92.
Heinricher MM, Drasner K. Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla. Brain Res. 1991 May 24; 549(2):338-41.
Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg. 1991 Mar; 72(3):275-81.
Miller AC, Scherba-Krugliak L, Toy PT, Drasner K. Hypotension during transfusion of autologous blood. Anesthesiology. 1991 Mar; 74(3):624-8.
Fassoulaki A, Drasner K, Eger EI. Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat? Anesth Analg. 1990 May; 70(5):489-92.
O'Connor ME, Drasner K. Preoperative laboratory testing of children undergoing elective surgery. Anesth Analg. 1990 Feb; 70(2):176-80.
Fang FG, Haws CM, Drasner K, Williamson A, Fields HL. Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res. 1989 Oct 30; 501(1):116-28.
Drasner K, Bernards CM, Ozanne GM. Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans. Anesthesiology. 1988 Sep; 69(3):310-2.
Drasner K, Fields HL. Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain. 1988 Mar; 32(3):309-312.