Jim Sonner, MD

Professor Emeritus

[email protected]
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Publications: 
Sonner JM, Cantor RS. Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys. 2013; 42:143-67.
Hsu TT, Leiske DL, Rosenfeld L, Sonner JM, Fuller GG. 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness. Langmuir. 2013 Feb 12; 29(6):1948-55.
Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI. Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2011 Sep; 113(3):500-4.
Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ. Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12143-8.
Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature. 2011 Jan 20; 469(7330):428-31.
Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI, Peterson AS, McIntire SL. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet. 2010 Aug 12; 6(8).
Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2009 Dec; 109(6):1816-22.
Weng Y, Yang L, Corringer PJ, Sonner JM. Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesth Analg. 2010 Jan 01; 110(1):59-63.
Weng Y, Hsu TT, Zhao J, Nishimura S, Fuller GG, Sonner JM. Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. Anesth Analg. 2009 May; 108(5):1538-45.
Milutinovic PS, Zhao J, Sonner JM. Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 2009 Jan; 108(1):176-80.
Sonner JM. A hypothesis on the origin and evolution of the response to inhaled anesthetics. Anesth Analg. 2008 Sep; 107(3):849-54.
Yang L, Sonner JM. Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia. Anesth Analg. 2008 Sep; 107(3):868-74.
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep; 107(3):832-48.
Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI. Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms. Anesth Analg. 2008 Aug; 107(2):507-24.
Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM. Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg. 2008 Aug; 107(2):479-85.
Hendrickx JF, Eger EI, Sonner JM, Shafer SL. Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008 Aug; 107(2):494-506.
Yost CS, Oh I, Eger EI, Sonner JM. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Behav Brain Res. 2008 Nov 21; 193(2):192-6.
Zhao J, Zhang Y, Eger EI, Sonner J. Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats. Chin Med Sci J. 2008 Mar; 23(1):16-8.
Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesth Analg. 2008 Mar; 106(3):838-45, table of contents.
Laster MJ, Zhang Y, Eger EI, Shnayderman D, Sonner JM. Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats. Anesth Analg. 2007 Sep; 105(3):661-5.
Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep; 105(3):673-9.
Milutinovic PS, Yang L, Cantor RS, Eger EI, Sonner JM. Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug; 105(2):386-92.
Cascio M, Xing Y, Gong D, Popovich J, Eger EI, Sen S, Peltz G, Sonner JM. Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Anesth Analg. 2007 Aug; 105(2):381-5.
Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug; 105(2):393-6.
Brosnan RJ, Eger EI, Laster MJ, Sonner JM. Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul; 105(1):103-6.
Sonner JM. Ethnicity can affect anesthetic requirement. Anesthesiology. 2007 Jul; 107(1):4-5.
Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun; 104(6):1430-3, table of contents.
Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM. Lidocaine, MK-801, and MAC. Anesth Analg. 2007 May; 104(5):1098-102, tables of contents.
Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM. Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats. Anesth Analg. 2007 Apr; 104(4):850-2.
Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI, Pearce RA. Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology. 2007 Jan; 106(1):114-23.
Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 2007 Jan; 106(1):107-13.
Tanifuji Y, Zhang Y, Liao M, Eger EI, Laster MJ, Sonner JM. Do dopamine receptors mediate part of MAC? Anesth Analg. 2006 Nov; 103(5):1177-81.
Won A, Oh I, Laster MJ, Popovich J, Eger EI, Sonner JM. Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):81-4, table of contents.
Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents.
Eger EI, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV, Sonner JM. Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg. 2006 May; 102(5):1397-406.
Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI. Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration? Anesth Analg. 2006 May; 102(5):1412-8.
Liao M, Laster MJ, Eger EI, Tang M, Sonner JM. Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice. Anesth Analg. 2006 May; 102(5):1452-5.
Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May; 102(5):1419-26.
Eger EI, Sonner JM. Anaesthesia defined (gentlemen, this is no humbug). Best Pract Res Clin Anaesthesiol. 2006 Mar; 20(1):23-9.
Won A, Oh I, Brosnan R, Eger EI, Sonner JM. Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3):247-50.
Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg. 2005 Aug; 101(2):412-418.
Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents.
Sonner JM, Vissel B, Royle G, Maurer A, Gong D, Baron NV, Harrison N, Fanselow M, Eger EI. The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene. Anesth Analg. 2005 Jul; 101(1):143-8, table of contents.
Sonner JM, Xing Y, Zhang Y, Maurer A, Fanselow MS, Dutton RC, Eger EI. Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane. Anesth Analg. 2005 May; 100(5):1333-1337.
Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE. Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol. 2005 Jul; 68(1):61-8.
Paris A, Ohlendorf C, Marquardt M, Bein B, Sonner JM, Scholz J, Tonner PH. The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors. Anesth Analg. 2005 Jan; 100(1):102-106.
Stabernack C, Zhang Y, Sonner JM, Laster M, Eger EI. Thiopental produces immobility primarily by supraspinal actions in rats. Anesth Analg. 2005 Jan; 100(1):128-136.
Xing Y, Sonner JM, Eger EI, Cascio M, Sessler DI. Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice. Anesthesiology. 2004 Aug; 101(2):544-6.
Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA. Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg. 2004 Jul; 99(1):85-90.
Eger EI, Laster MJ, Gregory GA, Katoh T, Sonner JM. Women appear to have the same minimum alveolar concentration as men: a retrospective study. Anesthesiology. 2003 Nov; 99(5):1059-61.
Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 2003 Sep; 97(3):718-740.
Zhang Y, Laster MJ, Eger EI, Stabernack CR, Sonner JM. Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Aug; 97(2):475-479.
Eger EI, Xing Y, Laster MJ, Sonner JM. Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Jun; 96(6):1661-1664.
Dutton RC, Zhang Y, Stabernack CR, Laster MJ, Sonner JM, Eger EI. Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia. Anesthesiology. 2003 Jun; 98(6):1372-7.
Eger EI, Xing Y, Laster M, Sonner J, Antognini JF, Carstens E. Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats. Anesth Analg. 2003 May; 96(5):1350-1353.
Eger EI, Xing Y, Pearce R, Shafer S, Laster MJ, Zhang Y, Fanselow MS, Sonner JM. Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone. Anesth Analg. 2003 Apr; 96(4):1010-1018.
Bovill JG, Sonner JM, Zhang Y, Stabernack C, Abaigar W, Xing Y, Laster MJ. GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner. Anesth Analg. 2003 Mar; 96(3):706-712.
Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI, Stabernack CR, Sonner JM. Glycine receptors mediate part of the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Jan; 96(1):97-101, table of contents.
Stabernack C, Sonner JM, Laster M, Zhang Y, Xing Y, Sharma M, Eger EI. Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane. Anesth Analg. 2003 Jan; 96(1):102-7, table of contents.
Flood P, Sonner JM, Gong D, Coates KM. Isoflurane hyperalgesia is modulated by nicotinic inhibition. Anesthesiology. 2002 Jul; 97(1):192-8.
Wong SM, Sonner JM, Kendig JJ. Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro. Anesth Analg. 2002 Jun; 94(6):1495-9, table of contents.
Eger EI, Zhang Y, Laster M, Flood P, Kendig JJ, Sonner JM. Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics. Anesth Analg. 2002 Jun; 94(6):1500-4, table of contents.
Sonner J, Fisher DM. Do sevoflurane and desflurane differ in upper airway reactivity? Anesthesiology. 2002 May; 96(5):1274-5; author reply 1275-6.
Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI. Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning. Anesthesiology. 2002 May; 96(5):1223-9.
Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI. Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory. Anesth Analg. 2002 Mar; 94(3):631-9; table of contents.