Jim Sonner, MD

Jim Sonner, MD

Professor Emeritus

Education

M.D., 1988 - School of Medicine, Harvard University
Residency, - School of Medicine, University of California, San Francisco

Publications

Molecular mechanisms of drug action: an emerging view.

Sonner JM, Cantor RS

3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness.

Hsu TT, Leiske DL, Rosenfeld L, Sonner JM, Fuller GG

Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.

Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.

Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ

Conserved role of unc-79 in ethanol responses in lightweight mutant mice.

Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI, Peterson AS, McIntire SL

Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.

Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.

Weng Y, Yang L, Corringer PJ, Sonner JM

Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine.

Weng Y, Hsu TT, Zhao J, Nishimura S, Fuller GG, Sonner JM

Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles.

Milutinovic PS, Zhao J, Sonner JM

A hypothesis on the origin and evolution of the response to inhaled anesthetics.

Sonner JM

Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia.

Yang L, Sonner JM

Is a new paradigm needed to explain how inhaled anesthetics produce immobility?

Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM

Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.

Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI

Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM

Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.

Hendrickx JF, Eger EI, Sonner JM, Shafer SL

Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.

Yost CS, Oh I, Eger EI, Sonner JM

Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats.

Zhao J, Zhang Y, Eger EI, Sonner J

The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors.

Yang L, Sonner JM

Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats.

Laster MJ, Zhang Y, Eger EI, Shnayderman D, Sonner JM

Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.

Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM

Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters.

Milutinovic PS, Yang L, Cantor RS, Eger EI, Sonner JM

Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration.

Cascio M, Xing Y, Gong D, Popovich J, Eger EI, Sen S, Peltz G, Sonner JM

The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function.

Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM

Anesthetic properties of carbon dioxide in the rat.

Brosnan RJ, Eger EI, Laster MJ, Sonner JM

Ethnicity can affect anesthetic requirement.

Sonner JM

Ammonia has anesthetic properties.

Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM

Lidocaine, MK-801, and MAC.

Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM

Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats.

Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM

Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.

Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI, Pearce RA

Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.

Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE

Do dopamine receptors mediate part of MAC?

Tanifuji Y, Zhang Y, Liao M, Eger EI, Laster MJ, Sonner JM

Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers.

Won A, Oh I, Laster MJ, Popovich J, Eger EI, Sonner JM

Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers.

Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM

Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.

Eger EI, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV, Sonner JM

Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?

Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI

Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice.

Liao M, Laster MJ, Eger EI, Tang M, Sonner JM

The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.

Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI

Anaesthesia defined (gentlemen, this is no humbug).

Eger EI, Sonner JM

Hypothermia decreases ethanol MAC in rats.

Won A, Oh I, Brosnan R, Eger EI, Sonner JM

Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI

R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit.

Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI

The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene.

Sonner JM, Vissel B, Royle G, Maurer A, Gong D, Baron NV, Harrison N, Fanselow M, Eger EI

Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane.

Sonner JM, Xing Y, Zhang Y, Maurer A, Fanselow MS, Dutton RC, Eger EI

Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear.

Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE

The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors.

Paris A, Ohlendorf C, Marquardt M, Bein B, Sonner JM, Scholz J, Tonner PH

Thiopental produces immobility primarily by supraspinal actions in rats.

Stabernack C, Zhang Y, Sonner JM, Laster M, Eger EI

Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.

Xing Y, Sonner JM, Eger EI, Cascio M, Sessler DI

Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.

Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA

Women appear to have the same minimum alveolar concentration as men: a retrospective study.

Eger EI, Laster MJ, Gregory GA, Katoh T, Sonner JM

Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.

Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI

Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics.

Zhang Y, Laster MJ, Eger EI, Stabernack CR, Sonner JM

Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics.

Eger EI, Xing Y, Laster MJ, Sonner JM

Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia.

Dutton RC, Zhang Y, Stabernack CR, Laster MJ, Sonner JM, Eger EI

Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats.

Eger EI, Xing Y, Laster M, Sonner J, Antognini JF, Carstens E

Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone.

Eger EI, Xing Y, Pearce R, Shafer S, Laster MJ, Zhang Y, Fanselow MS, Sonner JM

GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.

Bovill JG, Sonner JM, Zhang Y, Stabernack C, Abaigar W, Xing Y, Laster MJ

Glycine receptors mediate part of the immobility produced by inhaled anesthetics.

Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI, Stabernack CR, Sonner JM

Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane.

Stabernack C, Sonner JM, Laster M, Zhang Y, Xing Y, Sharma M, Eger EI

Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex.

Flood P, Sonner JM, Gong D, Coates KM

Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies.

Sonner JM

Isoflurane hyperalgesia is modulated by nicotinic inhibition.

Flood P, Sonner JM, Gong D, Coates KM

Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro.

Wong SM, Sonner JM, Kendig JJ

Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics.

Eger EI, Zhang Y, Laster M, Flood P, Kendig JJ, Sonner JM

Do sevoflurane and desflurane differ in upper airway reactivity?

Sonner J, Fisher DM

Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning.

Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI

Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory.

Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI