Role Faculty Location Zuckerberg San Francisco General Hospital Category Clinical Research Education M.D., 1979 - School of Medicine, University of California, San FranciscoResidency, - School of Medicine, University of California, San Francisco Publications Single Tri-Epitopic Antibodies (TeAbs) to Botulinum Neurotoxin Serotypes B, E, and F Recapitulate the Full Potency of a Combination of Three Monoclonal Antibodies in Toxin Neutralization. Lou J, Wen WH, Conrad F, Tam CC, Garcia-Rodriguez C, Farr-Jones S, Marks JD Toxins . Jun 4, 2025 Predictors of All-Cause 30-Day Readmissions in Patients with Heart Failure at an Urban Safety Net Hospital: The Importance of Social Determinants of Health and Mental Health. Steverson AB, Marano PJ, Chen C, Ma Y, Stern RJ, Feng J, Gennatas ED, Marks JD, Durstenfeld MS, Davis JD, Hsue PY, Zier LS American journal of medicine open . Sep 30, 2023 San Francisco's Citywide COVID-19 Response: Strategies to Reduce COVID-19 Severity and Health Disparities, March 2020 Through May 2022. Sachdev DD, Petersen M, Havlir DV, Schwab J, Enanoria WTA, Nguyen TQ, Mercer MP, Scheer S, Bennett A, Tenner AG, Marks JD, Bobba N, Philip S, Colfax G Public health reports (Washington, D.C. : 1974) . Jul 5, 2023 A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice. Fan Y, Lou J, Tam CC, Wen W, Conrad F, Leal da Silva Alves P, Cheng LW, Garcia-Rodriguez C, Farr-Jones S, Marks JD Toxins . Apr 30, 2023 Multicolor fluorescence activated cell sorting to generate humanized monoclonal antibody binding seven subtypes of BoNT/F. Fan Y, Sun Z, Conrad F, Wen W, Zhao L, Lou J, Zhou Y, Farr-Jones S, Marks JD PloS one . Sep 1, 2022 Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model. Tomic MT, Farr-Jones S, Syar ES, Niemuth N, Kobs D, Hackett MJ, Espinoza Y, Martinez Z, Pham K, Snow DM, Marks JD, Cobb RR Toxins . Sep 21, 2021 A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D. Garcia-Rodriguez C, Yan S, Geren IN, Knopp KA, Dong J, Sun Z, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD Toxins . Sep 10, 2021 A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model. Snow DM, Cobb RR, Martinez J, Finger-Baker I, Collins L, Terpening S, Syar ES, Niemuth N, Kobs D, Barnewall R, Farr-Jones S, Marks JD, Tomic MT Toxins . Jan 5, 2021 Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed Nanotherapeutic. Kamoun W, Swindell E, Pien C, Luus L, Cain J, Pham M, Kandela I, Huang ZR, Tipparaju SK, Koshkaryev A, Askoxylakis V, Kirpotin DB, Bloom T, Mino-Kenudson M, Marks JD, Zalutskaya A, Bshara W, Morrison C, Drummond DC Pharmaceutics . Oct 20, 2020 Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL Cell . Jan 16, 2020 The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA. Fan Y, Barash JR, Conrad F, Lou J, Tam C, Cheng LW, Arnon SS, Marks JD Toxins . Dec 20, 2019 Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity. Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A Science Translational Medicine . Oct 2, 2019 Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. Snow DM, Riling K, Kimbler A, Espinoza Y, Wong D, Pham K, Martinez Z, Kraus CN, Conrad F, Garcia-Rodriguez C, Cobb RR, Marks JD, Tomic MT Antimicrobial agents and chemotherapy . Sep 9, 2019 Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats. Espinoza Y, Wong D, Ahene A, Der K, Martinez Z, Pham J, Cobb RR, Farr-Jones S, Marks JD, Tomic MT Toxins . Jun 17, 2019 Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model. Tomic MT, Espinoza Y, Martinez Z, Pham K, Cobb RR, Snow DM, Earnhart CG, Pals T, Syar ES, Niemuth N, Kobs DJ, Farr-Jones S, Marks JD Toxins . Apr 6, 2019 Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models. Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC Nature biomedical engineering . Apr 5, 2019 Botulinum Neurotoxins (BoNTs)-Antibody and Vaccine. Lou J, Marks JD Toxins . Nov 26, 2018 Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL JCI Insight . Oct 18, 2018 Antibody engineering to improve manufacturability. Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH Protein expression and purification . Apr 12, 2018 A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes. Garcia-Rodriguez C, Razai A, Geren IN, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD Toxins . Mar 1, 2018 A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A. Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, Garcia-Rodriguez C, Farr-Jones S, Cheng LW, Henderson TD, Brown JL, Smith TJ, Smith LA, Cormier A, Marks JD Toxins . Feb 15, 2018 Discovery of internalizing antibodies to basal breast cancer cells. Zhou Y, Zou H, Yau C, Zhao L, Hall SC, Drummond DC, Farr-Jones S, Park JW, Benz CC, Marks JD Protein engineering, design & selection : PEDS . Jan 1, 2018 A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes. Fan Y, Garcia-Rodriguez C, Lou J, Wen W, Conrad F, Zhai W, Smith TJ, Smith LA, Marks JD PloS one . Mar 21, 2017 Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting. Geddie ML, Kohli N, Kirpotin DB, Razlog M, Jiao Y, Kornaga T, Rennard R, Xu L, Schoerberl B, Marks JD, Drummond DC, Lugovskoy AA mAbs . Nov 17, 2016 White Matter Injury and General Movements in High-Risk Preterm Infants. Peyton C, Yang E, Msall ME, Adde L, Støen R, Fjørtoft T, Bos AF, Einspieler C, Zhou Y, Schreiber MD, Marks JD, Drobyshevsky A AJNR. American journal of neuroradiology . Oct 27, 2016 Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. Fan Y, Barash JR, Lou J, Conrad F, Marks JD, Arnon SS The Journal of infectious diseases . Mar 1, 2016 Development and Implementation of Checklists for Routine Anesthesia Care: A Proposal for Improving Patient Safety. Krombach JW, Marks JD, Dubowitz G, Radke OC Anesthesia and analgesia . Oct 1, 2015 Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5. Le Gall M, Crépin R, Neiveyans M, Auclair C, Fan Y, Zhou Y, Marks JD, Pèlegrin A, Poul MA Molecular cancer therapeutics . Sep 10, 2015 Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B. Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren IN, Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD Toxins . Aug 26, 2015 Checklists and Other Cognitive Aids For Emergency And Routine Anesthesia Care-A Survey on the Perception of Anesthesia Providers From a Large Academic US Institution. Krombach JW, Edwards WA, Marks JD, Radke OC Anesthesiology and pain medicine . Aug 22, 2015 Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation. Seldon TA, Pryor R, Palkova A, Jones ML, Verma ND, Findova M, Braet K, Sheng Y, Fan Y, Zhou EY, Marks JD, Munro T, Mahler SM, Barnard RT, Fromm PD, Silveira PA, Elgundi Z, Ju X, Clark GJ, Bradstock KF, Munster DJ, Hart DN Leukemia . Aug 19, 2015 Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. Fan Y, Geren IN, Dong J, Lou J, Wen W, Conrad F, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD PloS one . Aug 14, 2015 TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL Journal of immunology (Baltimore, Md. : 1950) . Jun 24, 2015 A fully human scFv phage display library for rapid antibody fragment reformatting. Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM Protein engineering, design & selection : PEDS . May 19, 2015 Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL The Journal of biological chemistry . Apr 27, 2015 Combining anti-ERBB3 antibodies specific for domain I and domain III enhances the anti-tumor activity over the individual monoclonal antibodies. D'Souza JW, Reddy S, Goldsmith LE, Shchaveleva I, Marks JD, Litwin S, Robinson MK PloS one . Nov 11, 2014 High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display. Zhao L, Qu L, Zhou J, Sun Z, Zou H, Chen YY, Marks JD, Zhou Y PloS one . Oct 29, 2014 Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments. Li K, Tavaré R, Zettlitz KA, Mumenthaler SM, Mallick P, Zhou Y, Marks JD, Wu AM Molecular cancer therapeutics . Aug 20, 2014 Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins. Jenko KL, Zhang Y, Kostenko Y, Fan Y, Garcia-Rodriguez C, Lou J, Marks JD, Varnum SM The Analyst . Aug 12, 2014 Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific ⁶⁴Cu-DOTA conjugation. Tavaré R, Wu WH, Zettlitz KA, Salazar FB, McCabe KE, Marks JD, Wu AM Protein engineering, design & selection : PEDS . Aug 4, 2014 Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL Science Translational Medicine . Jun 18, 2014 Identifying blood-brain-barrier selective single-chain antibody fragments. Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV Biotechnology journal . Mar 18, 2014 Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. Strotmeier J, Mahrhold S, Krez N, Janzen C, Lou J, Marks JD, Binz T, Rummel A FEBS letters . Feb 25, 2014 RNA aptasensor for rapid detection of natively folded type A botulinum neurotoxin. Janardhanan P, Mello CM, Singh BR, Lou J, Marks JD, Cai S Talanta . Sep 13, 2013 Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E. Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T The Biochemical journal . Jul 1, 2013 Use of a new functional dual coating (FDC) assay to measure low toxin levels in serum and food samples following an outbreak of human botulism. Jones RGA, Marks JD Journal of medical microbiology . Mar 21, 2013 Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT Sarcoma . Sep 11, 2012 Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays. Zhang Y, Lou J, Jenko KL, Marks JD, Varnum SM Analytical biochemistry . Aug 27, 2012 Engineered domain-based assays to identify individual antibodies in oligoclonal combinations targeting the same protein. Meng Q, Garcia-Rodriguez C, Manzanarez G, Silberg MA, Conrad F, Bettencourt J, Pan X, Breece T, To R, Li M, Lee D, Thorner L, Tomic MT, Marks JD Analytical biochemistry . Aug 21, 2012 N-Terminal labeling of filamentous phage to create cancer marker imaging agents. Carrico ZM, Farkas ME, Zhou Y, Hsiao SC, Marks JD, Chokhawala H, Clark DS, Francis MB ACS nano . Aug 6, 2012 An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM Molecular imaging and biology . Jun 1, 2012 Selection and characterization of cell binding and internalizing phage antibodies. Zhou Y, Zhao L, Marks JD Archives of biochemistry and biophysics . May 22, 2012 Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies. Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD Molecular cancer therapeutics . May 7, 2012 A functional dual-coated (FDC) microtiter plate method to replace the botulinum toxin LD50 test. Liu YY, Rigsby P, Sesardic D, Marks JD, Jones RG Analytical biochemistry . Mar 6, 2012 Building and characterizing antibody-targeted lipidic nanotherapeutics. Kirpotin DB, Noble CO, Hayes ME, Huang Z, Kornaga T, Zhou Y, Nielsen UB, Marks JD, Drummond DC Methods in enzymology . Jan 1, 2012 Discovery of internalizing antibodies to tumor antigens from phage libraries. Zhou Y, Marks JD Methods in enzymology . Jan 1, 2012 Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong C, Hittelman WN, Wen X, Marks JW, Cheung LH, Boland K, Li C, Adams GP, Rosenblum MG Molecular cancer therapeutics . Nov 16, 2011 Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies. Kalb SR, Santana WI, Geren IN, Garcia-Rodriguez C, Lou J, Smith TJ, Marks JD, Smith LA, Pirkle JL, Barr JR BMC biochemistry . Nov 15, 2011 Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus. Wang Y, Keck ZY, Saha A, Xia J, Conrad F, Lou J, Eckart M, Marks JD, Foung SKH The Journal of biological chemistry . Oct 14, 2011 Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein. Meng Q, Li M, Silberg MA, Conrad F, Bettencourt J, To R, Huang C, Ma J, Meyer K, Shimizu R, Cao L, Tomic MT, Marks JD Analytical biochemistry . Oct 6, 2011 Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL The Journal of clinical investigation . Jun 6, 2011 Synergistic capture of Clostridium botulinum type A neurotoxin by scFv antibodies to novel epitopes. Gray SA, Barr JR, Kalb SR, Marks JD, Baird CL, Cangelosi GA, Miller KD, Feldhaus MJ Biotechnology and bioengineering . May 12, 2011 Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, Marks JD, Adams GP Cancer research . Mar 15, 2011 Evaluation of the anti-HER2 C6.5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Reddy S, Shaller CC, Doss M, Shchaveleva I, Marks JD, Yu JQ, Robinson MK Clinical cancer research : an official journal of the American Association for Cancer Research . Dec 21, 2010 Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin. Garcia-Rodriguez C, Geren IN, Lou J, Conrad F, Forsyth C, Wen W, Chakraborti S, Zao H, Manzanarez G, Smith TJ, Brown J, Tepp WH, Liu N, Wijesuriya S, Tomic MT, Johnson EA, Smith LA, Marks JD Protein engineering, design & selection : PEDS . Dec 13, 2010 Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens. Zhou Y, Zou H, Zhang S, Marks JD Journal of molecular biology . Sep 17, 2010 Extraction of BoNT/A, /B, /E, and /F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by Endopep-MS. Kalb SR, Garcia-Rodriguez C, Lou J, Baudys J, Smith TJ, Marks JD, Smith LA, Pirkle JL, Barr JR PloS one . Aug 17, 2010 TSG101 exposure on the surface of HIV-1 infected cells: implications for monoclonal antibody therapy for HIV/AIDS. Diaz L, Mao H, Zhou Y, Kohli M, Cassella J, Santos D, Fesseha Z, Weng K, Chen H, Bamba D, Marks JD, Goldblatt M, Kinch M American journal of translational research . Jul 20, 2010 Development of human single-chain antibodies to the transferrin receptor that effectively antagonize the growth of leukemias and lymphomas. Crépin R, Goenaga AL, Jullienne B, Bougherara H, Legay C, Benihoud K, Marks JD, Poul MA Cancer research . Jun 8, 2010 An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM European journal of nuclear medicine and molecular imaging . Apr 1, 2010 Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating. Lou J, Geren I, Garcia-Rodriguez C, Forsyth CM, Wen W, Knopp K, Brown J, Smith T, Smith LA, Marks JD Protein engineering, design & selection : PEDS . Feb 15, 2010 Tumor detection by imaging proteolytic activity. Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS Cancer research . Feb 9, 2010 A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. Dong J, Thompson AA, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD Journal of molecular biology . Feb 6, 2010 Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies. Cao Y, Marks JD, Marks JW, Cheung LH, Kim S, Rosenblum MG Cancer research . Nov 24, 2009 Development of a highly stable and targetable nanoliposomal formulation of topotecan. Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB Journal of controlled release : official journal of the Controlled Release Society . Aug 15, 2009 Antibody protection against botulinum neurotoxin intoxication in mice. Cheng LW, Stanker LH, Henderson TD, Lou J, Marks JD Infection and immunity . Aug 3, 2009 Rapid multiplexed flow cytometric assay for botulinum neurotoxin detection using an automated fluidic microbead-trapping flow cell for enhanced sensitivity. Ozanich RM, Bruckner-Lea CJ, Warner MG, Miller K, Antolick KC, Marks JD, Lou J, Grate JW Analytical chemistry . Jul 15, 2009 Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies. Warner MG, Grate JW, Tyler A, Ozanich RM, Miller KD, Lou J, Marks JD, Bruckner-Lea CJ Biosensors & bioelectronics . Jun 26, 2009 Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies. Kalb SR, Lou J, Garcia-Rodriguez C, Geren IN, Smith TJ, Moura H, Marks JD, Smith LA, Pirkle JL, Barr JR PloS one . Apr 28, 2009 Renewable surface fluorescence sandwich immunoassay biosensor for rapid sensitive botulinum toxin detection in an automated fluidic format. Grate JW, Warner MG, Ozanich RM, Miller KD, Colburn HA, Dockendorff B, Antolick KC, Anheier NC, Lind MA, Lou J, Marks JD, Bruckner-Lea CJ The Analyst . Mar 5, 2009 Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. Conrad F, Zhu X, Zhang X, Chalkley RJ, Burlingame AL, Marks JD, Liu B Journal of molecular medicine (Berlin, Germany) . Feb 14, 2009 Characterization of highly stable liposomal and immunoliposomal formulations of vincristine and vinblastine. Noble CO, Guo Z, Hayes ME, Marks JD, Park JW, Benz CC, Kirpotin DB, Drummond DC Cancer chemotherapy and pharmacology . Jan 30, 2009 Identification of target and function specific antibodies for effective drug delivery. Zhou Y, Marks JD Methods in molecular biology (Clifton, N.J.) . Jan 1, 2009 Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? Dimitrov DS, Marks JD Methods in molecular biology (Clifton, N.J.) . Jan 1, 2009 Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Shimazaki K, Lepin EJ, Wei B, Nagy AK, Coulam CP, Mareninov S, Fu M, Wu AM, Marks JD, Braun J, Gordon LK, Wadehra M Clinical cancer research : an official journal of the American Association for Cancer Research . Nov 15, 2008 Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Robinson MK, Hodge KM, Horak E, Sundberg AL, Russeva M, Shaller CC, von Mehren M, Shchaveleva I, Simmons HH, Marks JD, Adams GP British journal of cancer . Oct 7, 2008 Development of human single-chain antibodies against SARS-associated coronavirus. Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW Intervirology . Aug 25, 2008 Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies. Robinson MK, Shaller C, Garmestani K, Plascjak PS, Hodge KM, Yuan QA, Marks JD, Waldmann TA, Brechbiel MW, Adams GP Clinical cancer research : an official journal of the American Association for Cancer Research . Feb 1, 2008 Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith LA, Marks JD, Xie G, Brettin TS PloS one . Dec 5, 2007 Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy. Fischer A, Garcia-Rodriguez C, Geren I, Lou J, Marks JD, Nakagawa T, Montal M The Journal of biological chemistry . Nov 20, 2007 Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Roth A, Drummond DC, Conrad F, Hayes ME, Kirpotin DB, Benz CC, Marks JD, Liu B Molecular cancer therapeutics . Oct 1, 2007 Redirected activity of human antitumor chimeric immune receptors is governed by antigen and receptor expression levels and affinity of interaction. Turatti F, Figini M, Balladore E, Alberti P, Casalini P, Marks JD, Canevari S, Mezzanzanica D Journal of immunotherapy (Hagerstown, Md. : 1997) . Oct 1, 2007 Affinity thresholds for membrane fusion triggering by viral glycoproteins. Hasegawa K, Hu C, Nakamura T, Marks JD, Russell SJ, Peng KW Journal of virology . Sep 5, 2007 Regulation of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent affinity for target antigen. Tang Y, Lou J, Alpaugh RK, Robinson MK, Marks JD, Weiner LM Journal of immunology (Baltimore, Md. : 1950) . Sep 1, 2007 Recombinant full-length human IgG1s targeting hormone-refractory prostate cancer. Liu B, Conrad F, Roth A, Drummond DC, Simko JP, Marks JD Journal of molecular medicine (Berlin, Germany) . Jun 7, 2007 Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA Molecular immunology . May 10, 2007 Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells. Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD Journal of molecular biology . May 10, 2007 Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Garcia-Rodriguez C, Levy R, Arndt JW, Forsyth CM, Razai A, Lou J, Geren I, Stevens RC, Marks JD Nature biotechnology . Dec 17, 2006 Genetic diversity among Botulinum Neurotoxin-producing clostridial strains. Hill KK, Smith TJ, Helma CH, Ticknor LO, Foley BT, Svensson RT, Brown JL, Johnson EA, Smith LA, Okinaka RT, Jackson PJ, Marks JD Journal of bacteriology . Nov 17, 2006 Increased target specificity of anti-HER2 genospheres by modification of surface charge and degree of PEGylation. Hayes ME, Drummond DC, Hong K, Zheng WW, Khorosheva VA, Cohen JA, C O N, Park JW, Marks JD, Benz CC, Kirpotin DB Molecular pharmaceutics . Nov 1, 2006 Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display. Levy R, Forsyth CM, LaPorte SL, Geren IN, Smith LA, Marks JD Journal of molecular biology . Oct 3, 2006 A novel assay for monitoring internalization of nanocarrier coupled antibodies. Nielsen UB, Kirpotin DB, Pickering EM, Drummond DC, Marks JD BMC immunology . Oct 2, 2006 Using phage display to select antibodies recognizing post-translational modifications independently of sequence context. Kehoe JW, Velappan N, Walbolt M, Rasmussen J, King D, Lou J, Knopp K, Pavlik P, Marks JD, Bertozzi CR, Bradbury AR Molecular & cellular proteomics : MCP . Sep 12, 2006 A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. Arndt JW, Jacobson MJ, Abola EE, Forsyth CM, Tepp WH, Marks JD, Johnson EA, Stevens RC Journal of molecular biology . Jul 27, 2006 Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW Cancer research . Jul 1, 2006 Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant antibodies. Varnum SM, Warner MG, Dockendorff B, Anheier NC, Lou J, Marks JD, Smith LA, Feldhaus MJ, Grate JW, Bruckner-Lea CJ Analytica Chimica Acta . May 2, 2006 Assembly of nucleic acid-lipid nanoparticles from aqueous-organic monophases. Hayes ME, Drummond DC, Hong K, Park JW, Marks JD, Kirpotin DB Biochimica et biophysica acta . Apr 17, 2006 Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery. Hayes ME, Drummond DC, Kirpotin DB, Zheng WW, Noble CO, Park JW, Marks JD, Benz CC, Hong K Gene therapy . Apr 1, 2006 Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers. Adams GP, Tai MS, McCartney JE, Marks JD, Stafford WF, Houston LL, Huston JS, Weiner LM Clinical cancer research : an official journal of the American Association for Cancer Research . Mar 1, 2006 Isolation of scFvs to in vitro produced extracellular domains of EGFR family members. Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou Y, Yuan QA, Weiner LM, Adams GP, Marks JD Cancer biotherapy & radiopharmaceuticals . Dec 1, 2005 Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Smith TJ, Lou J, Geren IN, Forsyth CM, Tsai R, Laporte SL, Tepp WH, Bradshaw M, Johnson EA, Smith LA, Marks JD Infection and immunity . Sep 1, 2005 Molecular evolution of antibody affinity for sensitive detection of botulinum neurotoxin type A. Razai A, Garcia-Rodriguez C, Lou J, Geren IN, Forsyth CM, Robles Y, Tsai R, Smith TJ, Smith LA, Siegel RW, Feldhaus M, Marks JD Journal of molecular biology . Aug 5, 2005 Infectious Disease and Bioterrorism. Hughes SC, Marks JD Anesthesiology clinics of North America . Mar 1, 2005 Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody. Robinson MK, Doss M, Shaller C, Narayanan D, Marks JD, Adler LP, González Trotter DE, Adams GP Cancer research . Feb 15, 2005 Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification. Nellis DF, Ekstrom DL, Kirpotin DB, Zhu J, Andersson R, Broadt TL, Ouellette TF, Perkins SC, Roach JM, Drummond DC, Hong K, Marks JD, Park JW, Giardina SL Biotechnology progress . Jan 1, 2005 Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis. Nellis DF, Giardina SL, Janini GM, Shenoy SR, Marks JD, Tsai R, Drummond DC, Hong K, Park JW, Ouellette TF, Perkins SC, Kirpotin DB Biotechnology progress . Jan 1, 2005 Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42. Manoutcharian K, Acero G, Munguia ME, Becerril B, Massieu L, Govezensky T, Ortiz E, Marks JD, Cao C, Ugen K, Gevorkian G Neurobiology of disease . Oct 1, 2004 A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice. Adams GP, Shaller CC, Dadachova E, Simmons HH, Horak EM, Tesfaye A, Klein-Szanto AJ, Marks JD, Brechbiel MW, Weiner LM Cancer research . Sep 1, 2004 Medical aspects of biologic toxins. Marks JD Anesthesiology clinics of North America . Sep 1, 2004 Development of ligand-targeted liposomes for cancer therapy. Noble CO, Kirpotin DB, Hayes ME, Mamot C, Hong K, Park JW, Benz CC, Marks JD, Drummond DC Expert opinion on therapeutic targets . Aug 1, 2004 Antibodies from phage antibody libraries. Bradbury AR, Marks JD Journal of immunological methods . Jul 1, 2004 Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies. Hall YH, Chaddock JA, Moulsdale HJ, Kirby ER, Alexander FC, Marks JD, Foster KA Journal of immunological methods . May 1, 2004 Yeast mating for combinatorial Fab library generation and surface display. Weaver-Feldhaus JM, Lou J, Coleman JR, Siegel RW, Marks JD, Feldhaus MJ FEBS letters . Apr 23, 2004 Deciphering antibody properties that lead to potent botulinum neurotoxin neutralization. Marks JD Movement disorders : official journal of the Movement Disorder Society . Mar 1, 2004 Characterization of a single-chain intrabody directed against the human receptor tyrosine kinase Ron. Secco P, Ferretti M, Gioia D, Cesaro P, Bozzo C, Marks JD, Santoro C Journal of immunological methods . Feb 1, 2004 Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells. Liu B, Conrad F, Cooperberg MR, Kirpotin DB, Marks JD Cancer research . Jan 15, 2004 Antibody affinity maturation by chain shuffling. Marks JD Methods in molecular biology (Clifton, N.J.) . Jan 1, 2004 PCR cloning of human immunoglobulin genes. Marks JD, Bradbury A Methods in molecular biology (Clifton, N.J.) . Jan 1, 2004 Selection of human antibodies from phage display libraries. Marks JD, Bradbury A Methods in molecular biology (Clifton, N.J.) . Jan 1, 2004 Selection of internalizing antibodies for drug delivery. Marks JD Methods in molecular biology (Clifton, N.J.) . Jan 1, 2004 Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells. Mamot C, Drummond DC, Greiser U, Hong K, Kirpotin DB, Marks JD, Park JW Cancer research . Jun 15, 2003 Predicting antigenic peptides suitable for the selection of phage antibodies. Pavlik P, Siegel RW, Marzari R, Sblattero D, Verzillo V, Collins C, Marks JD, Bradbury A Human antibodies . Jan 1, 2003 The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: in vitro and in vivo studies. Marzari R, Sblattero D, Macor P, Fischetti F, Gennaro R, Marks JD, Bradbury A, Tedesco F European journal of immunology . Oct 1, 2002 Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis. Nielsen UB, Kirpotin DB, Pickering EM, Hong K, Park JW, Refaat Shalaby M, Shao Y, Benz CC, Marks JD Biochimica et biophysica acta . Aug 19, 2002 Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody. Nowakowski A, Wang C, Powers DB, Amersdorfer P, Smith TJ, Montgomery VA, Sheridan R, Blake R, Smith LA, Marks JD Proceedings of the National Academy of Sciences of the United States of America . Aug 12, 2002 Phage versus phagemid libraries for generation of human monoclonal antibodies. O'Connell D, Becerril B, Roy-Burman A, Daws M, Marks JD Journal of molecular biology . Aug 2, 2002 Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV. Frank DW, Vallis A, Wiener-Kronish JP, Roy-Burman A, Spack EG, Mullaney BP, Megdoud M, Marks JD, Fritz R, Sawa T The Journal of infectious diseases . Jun 14, 2002 Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Park JW, Hong K, Kirpotin DB, Colbern G, Shalaby R, Baselga J, Shao Y, Nielsen UB, Marks JD, Moore D, Papahadjopoulos D, Benz CC Clinical cancer research : an official journal of the American Association for Cancer Research . Apr 1, 2002 The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. Visintin M, Settanni G, Maritan A, Graziosi S, Marks JD, Cattaneo A Journal of molecular biology . Mar 15, 2002 Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries. Amersdorfer P, Wong C, Smith T, Chen S, Deshpande S, Sheridan R, Marks JD Vaccine . Feb 22, 2002 Phage-display antibody detection of Chlamydia trachomatis-associated antigens. Lindquist EA, Marks JD, Kleba BJ, Stephens RS Microbiology (Reading, England) . Feb 1, 2002 Towards proteome-wide production of monoclonal antibody by phage display. Liu B, Huang L, Sihlbom C, Burlingame A, Marks JD Journal of molecular biology . Feb 1, 2002 Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display. Mullaney BP, Pallavicini MG, Marks JD Infection and immunity . Oct 1, 2001 Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells. Li X, Stuckert P, Bosch I, Marks JD, Marasco WA Cancer gene therapy . Aug 1, 2001 Tumor targeting using anti-her2 immunoliposomes. Park JW, Kirpotin DB, Hong K, Shalaby R, Shao Y, Nielsen UB, Marks JD, Papahadjopoulos D, Benz CC Journal of controlled release : official journal of the Controlled Release Society . Jul 6, 2001 High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Adams GP, Schier R, McCall AM, Simmons HH, Horak EM, Alpaugh RK, Marks JD, Weiner LM Cancer research . Jun 15, 2001 Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity. McCall AM, Shahied L, Amoroso AR, Horak EM, Simmons HH, Nielson U, Adams GP, Schier R, Marks JD, Weiner LM Journal of immunology (Baltimore, Md. : 1950) . May 15, 2001 Anomalous enhancement of botulinum toxin type A neurotoxicity in the presence of antitoxin. Sheridan RE, Deshpande SS, Amersdorfer P, Marks JD, Smith T Toxicon : official journal of the International Society on Toxinology . May 1, 2001 Expression of single-chain Fv-Fc fusions in Pichia pastoris. Powers DB, Amersdorfer P, Poul M, Nielsen UB, Shalaby MR, Adams GP, Weiner LM, Marks JD Journal of immunological methods . May 1, 2001 Antibodies to human fetal erythroid cells from a nonimmune phage antibody library. Huie MA, Cheung MC, Muench MO, Becerril B, Kan YW, Marks JD Proceedings of the National Academy of Sciences of the United States of America . Feb 27, 2001 Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library. Heitner T, Moor A, Garrison JL, Marks C, Hasan T, Marks JD Journal of immunological methods . Feb 1, 2001 Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function. Neve RM, Nielsen UB, Kirpotin DB, Poul MA, Marks JD, Benz CC Biochemical and biophysical research communications . Jan 12, 2001 Engineering and characterization of a novel fusion protein incorporating B7.2 and an anti-ErbB-2 single-chain antibody fragment for the activation of Jurkat T cells. Marshall KW, Marks JD Journal of immunotherapy (Hagerstown, Md. : 1997) . Jan 1, 2001 Lung collapse during low tidal volume ventilation in acute respiratory distress syndrome. Kallet RH, Siobal MS, Alonso JA, Warnecke EL, Katz JA, Marks JD Respiratory care . Jan 1, 2001 Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Nielsen UB, Adams GP, Weiner LM, Marks JD Cancer research . Nov 15, 2000 Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Liu B, Marks JD Analytical biochemistry . Nov 1, 2000 Mass spectral analysis of a protein complex using single-chain antibodies selected on a peptide target: applications to functional genomics. Siegel RW, Allen B, Pavlik P, Marks JD, Bradbury A Journal of molecular biology . Sep 15, 2000 Measuring intra-esophageal pressure to assess transmural pulmonary arterial occlusion pressure in patients with acute lung injury: a case series and review. Kallet RH, Katz JA, Pittet JF, Ghermey J, Siobal M, Alonso JA, Marks JD Respiratory care . Sep 1, 2000 Selection of tumor-specific internalizing human antibodies from phage libraries. Poul MA, Becerril B, Nielsen UB, Morisson P, Marks JD Journal of molecular biology . Sep 1, 2000 Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules. Adams GP, Shaller CC, Chappell LL, Wu C, Horak EM, Simmons HH, Litwin S, Marks JD, Weiner LM, Brechbiel MW Nuclear medicine and biology . May 1, 2000 The treatment of acidosis in acute lung injury with tris-hydroxymethyl aminomethane (THAM). Kallet RH, Jasmer RM, Luce JM, Lin LH, Marks JD American journal of respiratory and critical care medicine . Apr 1, 2000 Improved flow and pressure capabilities of the Datex-Ohmeda SmartVent anesthesia ventilator. Katz JA, Kallet RH, Alonso JA, Marks JD Journal of clinical anesthesia . Feb 1, 2000 Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF Critical Care Medicine . Jan 1, 2000 Phage libraries for generation of anti-botulinum scFv antibodies. Amersdorfer P, Marks JD Methods in molecular biology (Clifton, N.J.) . Jan 1, 2000 Disruption of anthrax toxin binding with the use of human antibodies and competitive inhibitors. Cirino NM, Sblattero D, Allen D, Peterson SR, Marks JD, Jackson PJ, Bradbury A, Lehnert BE Infection and immunity . Jun 1, 1999 Synthesis of Rh Fv phage-antibodies using VH and VL germline genes. Hughes-Jones NC, Bye JM, Gorick BD, Marks JD, Ouwehand WH British journal of haematology . Jun 1, 1999 Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis. McCall AM, Adams GP, Amoroso AR, Nielsen UB, Zhang L, Horak E, Simmons H, Schier R, Marks JD, Weiner LM Molecular immunology . May 1, 1999 Targeted gene delivery to mammalian cells by filamentous bacteriophage. Poul MA, Marks JD Journal of molecular biology . Apr 30, 1999 Toward selection of internalizing antibodies from phage libraries. Becerril B, Poul MA, Marks JD Biochemical and biophysical research communications . Feb 16, 1999 Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries. McCall AM, Amoroso AR, Sautès C, Marks JD, Weiner LM Immunotechnology : an international journal of immunological engineering . Jun 1, 1998 Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD, Lindqvist E Proceedings of the National Academy of Sciences of the United States of America . May 26, 1998 Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu. Adams GP, Schier R, McCall AM, Crawford RS, Wolf EJ, Weiner LM, Marks JD British journal of cancer . May 1, 1998 Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients. Cammarano WB, Pittet JF, Weitz S, Schlobohm RM, Marks JD Critical Care Medicine . Apr 1, 1998 Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies. Adams GP, Schier R, Marshall K, Wolf EJ, McCall AM, Marks JD, Weiner LM Cancer research . Feb 1, 1998 Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries. Amersdorfer P, Wong C, Chen S, Smith T, Deshpande S, Sheridan R, Finnern R, Marks JD Infection and immunity . Sep 1, 1997 Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms. Chen F, Kuziemko GM, Amersdorfer P, Wong C, Marks JD, Stevens RC Infection and immunity . May 1, 1997 Human autoimmune anti-proteinase 3 scFv from a phage display library. Finnern R, Pedrollo E, Fisch I, Wieslander J, Marks JD, Lockwood CM, Ouwehand WH Clinical and experimental immunology . Feb 1, 1997 Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site. Schier R, McCall A, Adams GP, Marshall KW, Merritt H, Yim M, Crawford RS, Weiner LM, Marks C, Marks JD Journal of molecular biology . Nov 8, 1996 Phage libraries--a new route to clinically useful antibodies. Marks C, Marks JD The New England journal of medicine . Sep 5, 1996 Identification of functional and structural amino-acid residues by parsimonious mutagenesis. Schier R, Balint RF, McCall A, Apell G, Larrick JW, Marks JD Gene . Mar 9, 1996 Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection. Schier R, Bye J, Apell G, McCall A, Adams GP, Malmqvist M, Weiner LM, Marks JD Journal of molecular biology . Jan 12, 1996 Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections. Schier R, Marks JD Human antibodies and hybridomas . Jan 1, 1996 Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries. Finnern R, Bye JM, Dolman KM, Zhao MH, Short A, Marks JD, Lockwood MC, Ouwehand WH Clinical and experimental immunology . Dec 1, 1995 In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Schier R, Marks JD, Wolf EJ, Apell G, Wong C, McCartney JE, Bookman MA, Huston JS, Houston LL, Weiner LM Immunotechnology : an international journal of immunological engineering . May 1, 1995 Characterization of human blood group scFv antibodies derived from a V gene phage-display library. Hughes-Jones NC, Gorick BD, Bye JM, Finnern R, Scott ML, Voak D, Marks JD, Ouwehand WH British journal of haematology . Sep 1, 1994 In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation. Figini M, Marks JD, Winter G, Griffiths AD Journal of molecular biology . May 27, 1994 Fiberoptic-aided endobronchial intubation. Marks JD International anesthesiology clinics . Jan 1, 1994 Performing fiberoptic endotracheal intubation: clinical aspects. Stackhouse RA, Marks JD, Bainton CR International anesthesiology clinics . Jan 1, 1994 Practical aspects of fiberoptic laryngobronchoscopy. Marks JD, Bainton CR International anesthesiology clinics . Jan 1, 1994 The humoral immune response against blood group antigens at the molecular level. Ouwehand WH, Bye JM, Gorick BD, Marks JD, Timmers E, Griffin HM, Finnern R, Hughes-Jones N Vox sanguinis . Jan 1, 1994 Human antibody fragments specific for human blood group antigens from a phage display library. Marks JD, Ouwehand WH, Bye JM, Finnern R, Gorick BD, Voak D, Thorpe SJ, Hughes-Jones NC, Winter G Bio/technology (Nature Publishing Company) . Oct 1, 1993 Human anti-self antibodies with high specificity from phage display libraries. Griffiths AD, Malmqvist M, Marks JD, Bye JM, Embleton MJ, McCafferty J, Baier M, Holliger KP, Gorick BD, Hughes-Jones NC The EMBO journal . Feb 1, 1993 Building antibodies from their genes. Hoogenboom HR, Marks JD, Griffiths AD, Winter G Immunological reviews . Dec 1, 1992 Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift. Bye JM, Carter C, Cui Y, Gorick BD, Songsivilai S, Winter G, Hughes-Jones NC, Marks JD The Journal of clinical investigation . Dec 1, 1992 Structural repertoire of the human VH segments. Chothia C, Lesk AM, Gherardi E, Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G Journal of molecular biology . Oct 5, 1992 The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G Journal of molecular biology . Oct 5, 1992 Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system. Marks JD, Hoogenboom HR, Griffiths AD, Winter G The Journal of biological chemistry . Aug 15, 1992 By-passing immunization: building high affinity human antibodies by chain shuffling. Marks JD, Griffiths AD, Malmqvist M, Clackson TP, Bye JM, Winter G Bio/technology (Nature Publishing Company) . Jul 1, 1992 An artificial immune system for making antibodies. Marks JD, Winter G Behring Institute Mitteilungen . Apr 1, 1992 By-passing immunization. Human antibodies from V-gene libraries displayed on phage. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, Winter G Journal of molecular biology . Dec 5, 1991 Airway management for trauma patients with potential cervical spine injuries. Hastings RH, Marks JD Anesthesia and analgesia . Oct 1, 1991 Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Marks JD, Tristem M, Karpas A, Winter G European journal of immunology . Apr 1, 1991 Cloning and sequencing of human lambda immunoglobulin genes by the polymerase chain reaction. Songsivilai S, Bye JM, Marks JD, Hughes-Jones NC European journal of immunology . Dec 1, 1990 Factors affecting perioperative pulmonary function in acute respiratory failure. Biery DR, Marks JD, Schapera A, Autry M, Schlobohm RM, Katz JA Chest . Dec 1, 1990 Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA The Journal of clinical investigation . Aug 1, 1990 Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. Marks JD, Marks CB, Luce JM, Montgomery AB, Turner J, Metz CA, Murray JF The American review of respiratory disease . Jan 1, 1990 Perioperative pulmonary function in acute respiratory failure: effect of ventilator type and gas mixture. Schapera A, Marks JD, Minagi H, Goodman P, Katz JA Anesthesiology . Sep 1, 1989 Pressure and flow limitations of anesthesia ventilators. Marks JD, Schapera A, Kraemer RW, Katz JA Anesthesiology . Sep 1, 1989 Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Luce JM, Montgomery AB, Marks JD, Turner J, Metz CA, Murray JF The American review of respiratory disease . Jul 1, 1988 Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K Anesthesiology . Jun 1, 1986 Inspiratory work with and without continuous positive airway pressure in patients with acute respiratory failure. Katz JA, Marks JD Anesthesiology . Dec 1, 1985 Effect of increases in lung volume on clearance of aerosolized solute from human lungs. Marks JD, Luce JM, Lazar NM, Wu JN, Lipavsky A, Murray JF Journal of applied physiology (Bethesda, Md. : 1985) . Oct 1, 1985 The inhibitory action of a phenothiazine derivative on the hexosemonophosphate dehydrogenases of adrenal cortex. MARKS JD, ROESKY N, CARVER MJ Archives of biochemistry and biophysics . Nov 1, 1961
