Role Faculty Location UCSF Benioff Children’s Hospital Oakland UCSF at Mission Bay Category Clinical Research Specialties Pediatric Cardiac Education Clinical fellow, 2011 - Pediatric Anesthesia, University of California, San FranciscoClinical fellow, 2010 - Pediatric Cardiac Anesthesia, University of California, San FranciscoResidency, 2009 - Anesthesia & Perioperative Care, University of California, San FranciscoInternship, 2006 - Pediatrics, University of California, San FranciscoM.D., Ph.D., 2005 - School of Medicine, University of Texas SouthwesternB.A., 1997 - Chemistry & International Relations, Claremont McKenna College Publications Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease. Kathiriya IS, Rao KS, Clark AP, Hu KM, Grant ZL, Matthews MN, Chen Z, Saucerman JJ, Hota SK, Bruneau BG bioRxiv : the preprint server for biology . Aug 19, 2025 Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor. Grant ZL, Kuang S, Zhang S, Horrillo AJ, Rao KS, Kameswaran V, Joubran C, Lau PK, Dong K, Yang B, Bartosik WM, Zemke NR, Ren B, Kathiriya IS, Pollard KS, Bruneau BG bioRxiv : the preprint server for biology . Jan 12, 2025 In preprints: insights into human heart development and congenital heart defects. Kathiriya IS Development (Cambridge, England) . Aug 15, 2024 A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients. Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR Pulmonary circulation . Apr 12, 2024 A TBX5-dependent compartment boundary patterns the cardiac interventricular septum. Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Patrick Devine W, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu PH, Wirtz D, Kiemen AL, Bruneau BG bioRxiv : the preprint server for biology . Feb 5, 2024 Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis. Blair AP, Hu RK, Farah EN, Chi NC, Pollard KS, Przytycki PF, Kathiriya IS, Bruneau BG Bioinformatics advances . Aug 4, 2022 Brahma safeguards canalization of cardiac mesoderm differentiation. Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, Kathiriya IS, Krogan NJ, Saucerman JJ, Bruneau BG Nature . Jan 26, 2022 Interactive anesthesiology educational program improves wellness for anesthesiologists and their children. Jung MJ, Libaw JS, Manuel SP, Kathiriya IS, Srejic U, Gandhi S Journal of clinical anesthesia . Feb 6, 2021 Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussler M, Pu WT, Stuart JM, Seidman CE, Seidman JG, Heyn H, Bruneau BG Developmental cell . Dec 14, 2020 Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG Development (Cambridge, England) . Dec 9, 2019 A TBX5 dosage-sensitive gene regulatory network for human congenital heart disease. Irfan S. Kathiriya, Kavitha S. Rao, Giovanni Iacono, W. Patrick Devine, Swetansu K. Hota, Michael H. Lai, Bayardo I. Garay, Reuben Thomas, Andrew P. Blair, Henry Z. Gong, Lauren K. Wasson, Piyush Goyal, Tatyana Sukonnik, Gunes A. Akgun, Laure D. Bernard, Brynn N. Akerberg, Fei Gu, Kai Li, William T. Pu, Joshua M. Stuart, Christine E. Seidman, J. G. Seidman, Holger Heyn, Benoit G. Bruneau bioRxiv . Nov 8, 2019 Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Matthew George, Qiming Duan, Abigail Nagle, Irfan Kathiriya, Yu Huang, Kavitha Rao, Saptarsi Haldar, Benoit Bruneau bioRxiv . Oct 4, 2019 The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN Development (Cambridge, England) . Mar 1, 2017 Single-Cell Resolution of Temporal Gene Expression during Heart Development. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE Developmental cell . Nov 10, 2016 Investigating the transcriptional control of cardiovascular development. Kathiriya IS, Nora EP, Bruneau BG Circulation research . Feb 13, 2015 Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V American journal of medical genetics. Part A . Apr 15, 2007 Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O Biochemical and biophysical research communications . Apr 27, 2006 Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG Nature genetics . Dec 25, 2005 Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O The Journal of biological chemistry . Oct 12, 2004 GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D Nature . Jul 6, 2003 Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D Developmental biology . Jul 1, 2001 Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA Development (Cambridge, England) . May 1, 2000 Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Kathiriya IS, Srivastava D American journal of medical genetics . Jan 1, 2000 Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Hamilton SE, Simmons CG, Kathiriya IS, Corey DR Chemistry & biology . Jun 1, 1999
