Danielle Williamson, BA, MD, PhD

HS Clinical Instructor
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What I do: 

Attended Oregon Health & Science University

Hobbies: Mountains - I like to climb up them, ski down them, run around them, and look at them from afar - Running - I try to get out to the trails every change I get - Proud plant parent, aspiring dog parent.

Publications: 1: Williamson DM, Elferich J, Shinde U. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. J Biol Chem. 2015 Sep 18;290(38):23214-25. doi: 10.1074/jbc.M115.665430. Epub 2015 Jul 30. PubMed PMID: 26229104; PubMed Central PMCID: PMC4645620.

2: Dillon SL, Williamson DM, Elferich J, Radler D, Joshi R, Thomas G, Shinde U. Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol. 2012 Oct 12;423(1):47-62. doi: 10.1016/j.jmb.2012.06.023. Epub 2012 Jun 25. PubMed PMID: 22743102; PubMed Central PMCID: PMC3444655.

3: Elferich J, Williamson DM, David LL, Shinde U. Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry. Anal Chem. 2015 Aug 4;87(15):7909-17. doi: 10.1021/acs.analchem.5b01721. Epub 2015 Jul 15. PubMed PMID: 26110992; PubMed Central PMCID: PMC4903077.

4: Elferich J, Williamson DM, Krishnamoorthy B, Shinde U. Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation. FASEB J. 2013 Aug;27(8):2939-45. doi: 10.1096/fj.12-226886. Epub 2013 Apr 12. PubMed PMID: 23585398; PubMed Central PMCID: PMC3714588.

5: Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U. The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem. 2013 Jun 28;288(26):19154-65. doi: 10.1074/jbc.M112.442681. Epub 2013 May 7. PubMed PMID: 23653353; PubMed Central PMCID: PMC3696687.

6: Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell. 2010 Oct 1;21(19):3279-92. doi: 10.1091/mbc.E10-05-0470. Epub 2010 Aug 11. PubMed PMID: 20702582; PubMed Central PMCID: PMC2947465.

7: Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell. 2009 May 14;34(4):497-509. doi: 10.1016/j.molcel.2009.04.011. PubMed PMID: 19481529; PubMed Central PMCID: PMC2744858.

Publications: 
Williamson DM, Sharma A. Cystic fibrosis in children: A pediatric anesthesiologist's perspective. Paediatr Anaesth. 2022 Feb; 32(2):167-173.
Williamson DM, Elferich J, Shinde U. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. J Biol Chem. 2015 Sep 18; 290(38):23214-25.
Elferich J, Williamson DM, David LL, Shinde U. Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry. Anal Chem. 2015 Aug 04; 87(15):7909-17.
Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U. The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem. 2013 Jun 28; 288(26):19154-65.
Elferich J, Williamson DM, Krishnamoorthy B, Shinde U. Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation. FASEB J. 2013 Aug; 27(8):2939-45.
Dillon SL, Williamson DM, Elferich J, Radler D, Joshi R, Thomas G, Shinde U. Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol. 2012 Oct 12; 423(1):47-62.
Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell. 2010 Oct 01; 21(19):3279-92.
Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell. 2009 May 14; 34(4):497-509.