Biography My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. Role Faculty Category Clinical Research Specialties Liver Transplant Publications Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors: A Randomized Clinical Trial. Patel MS, Salcedo-Betancourt JD, Saunders C, Broglio K, Malinoski D, Niemann CU International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World. Rodriguez-Davalos MI, Lopez-Verdugo F, Kasahara M, Muiesan P, Reddy MS, Flores-Huidobro Martinez A, Xia Q, Hong JC, Niemann CU, Seda-Neto J, Miloh TA, Yi NJ, Mazariegos GV, Ng VL, Esquivel CO, Lerut J, Rela M, Pediatric Liver Transplantation Global Census Group Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle? Galli AM, Kothari R, Adelmann D, Holm Z, Bokoch MP, De Gasperi A, Niemann CU, Kolodzie K Hypothermia or Machine Perfusion in Kidney Donors. Malinoski D, Saunders C, Swain S, Groat T, Wood PR, Reese J, Nelson R, Prinz J, Kishish K, Van De Walker C, Geraghty PJ, Broglio K, Niemann CU Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference. Pollok JM, Tinguely P, Berenguer M, Niemann CU, Raptis DA, Spiro M, ERAS4OLT.org collaborative Perioperative mortality in liver transplantation before and after the implementation of the organ allocation policy Share 35. Holm ZD, Kolodzie K, Galli AM, Meyhoff CS, Niemann CU, Adelmann D Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation. Meier RPH, Kelly Y, Yamaguchi S, Braun HJ, Lunow-Luke T, Adelmann D, Niemann C, Maluf DG, Dietch ZC, Stock PG, Kang SM, Feng S, Posselt AM, Gardner JM, Syed SM, Hirose R, Freise CE, Ascher NL, Roberts JP, Roll GR Expedited evaluation for liver transplantation: A critical look at processes and outcomes. Braun HJ, Mello A, Kothari R, Ku E, Yilma M, Tavakol M, Zhang L, Niemann CU, Ascher NL, Adelmann D Organ donor management goals and delayed graft function in adult kidney transplant recipients. Kothari R, Tolles J, Adelmann D, Lewis RJ, Malinoski DJ, Niemann CU Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study. Kolodzie K, Cakmakkaya OS, Boparai ES, Tavakol M, Feiner JR, Kim MO, Newman TB, Niemann CU Machine Learning Prediction of Liver Allograft Utilization From Deceased Organ Donors Using the National Donor Management Goals Registry. Bishara AM, Lituiev DS, Adelmann D, Kothari RP, Malinoski DJ, Nudel JD, Sally MB, Hirose R, Hadley DD, Niemann CU Enhanced recovery after surgery programs improve short-term outcomes after liver transplantation-A systematic review and meta-analysis. Tinguely P, Morare N, Ramirez-Del Val A, Berenguer M, Niemann CU, Pollok JM, Raptis DA, Spiro M Assessment of the global practice of living donor liver transplantation. Emamaullee J, Conrad C, Kim M, Goldbeck C, Kwon Y, Singh P, Niemann CU, Sher L, Genyk Y Raster Thomson scattering in large-scale laser plasmas produced at high repetition rate. Kaloyan M, Ghazaryan S, Constantin CG, Dorst RS, Heuer PV, Pilgram JJ, Schaeffer DB, Niemann C Critical care and ventilatory management of deceased organ donors impact lung use and recipient graft survival. Swanson EA, Patel MS, Hutchens MP, Niemann CU, Groat T, Malinoski DJ, Sally MB Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Yang F, Nielsen SCA, Hoh RA, Röltgen K, Wirz OF, Haraguchi E, Jean GH, Lee JY, Pham TD, Jackson KJL, Roskin KM, Liu Y, Nguyen K, Ohgami RS, Osborne EM, Nadeau KC, Niemann CU, Parsonnet J, Boyd SD Prospective Multicenter Study of Early Antiviral Therapy in Liver and Kidney Transplant Recipients of HCV-Viremic Donors. Terrault NA, Burton J, Ghobrial M, Verna E, Bayer J, Klein C, Victor D, Mohan S, Trotter J, Dodge J, Niemann CU, Rubin RA Weighing the waitlist: Weight changes and access to kidney transplantation among obese candidates. Ku E, Whelan AM, McCulloch CE, Lee B, Niemann CU, Roll GR, Grimes BA, Johansen KL COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions. Syed SM, Gardner J, Roll G, Webber A, Mehta N, Shoji J, Adelmann D, Niemann C, Braun HJ, Mello A, Yao F, Posselt A, Kang SM, Hirose R, Roberts J, Feng S, Ascher N, Stock P, Freise C The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation. Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D Measurements of ion velocity distributions in a large scale laser-produced plasma. Dorst RS, Heuer PV, Schaeffer DB, Constantin CG, Niemann C Longer Distance From Dialysis Facility to Transplant Center Is Associated With Lower Access to Kidney Transplantation. Whelan AM, Johansen KL, McCulloch CE, Adelmann D, Niemann CU, Roll GR, Siyahian S, Grimes B, Ku E Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG Impact of Deceased Donor Management on Donor Heart Use and Recipient Graft Survival. Swanson EA, Adams T, Patel MS, De La Cruz S, Hutchens M, Khush K, Sally MB, Niemann CU, Groat T, Malinoski DJ Bacchus Listed for a Liver Transplant: Comment. Niemann CU Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function. Swanson EA, Patel MS, Groat T, Jameson NE, Ellis MKM, Hutchens MP, Niemann CU, Malinoski DJ, Sally MB The role of deceased donor liver biopsy: An analysis of 5449 liver transplant recipients. Patel MS, Mohebali J, Coe TM, Sally M, Groat T, Niemann CU, Malinoski DJ, Vagefi PA Transplant anesthesia and critical care: Current research and possible future developments. Niemann CU, Biancofiore G Therapeutic Hypothermia in Organ Donors: Follow-up and Safety Analysis. Malinoski D, Patel MS, Axelrod DA, Broglio K, Lewis RJ, Groat T, Niemann CU Modeling the economic benefit of targeted mild hypothermia in deceased donor kidney transplantation. Axelrod DA, Malinoski D, Patel MS, Broglio K, Lewis R, Groat T, Lentine KL, Schnitzler M, Niemann CU The Continued Need for Clinical Trials in Deceased Organ Donor Management. Niemann CU, Matthay MA, Ware LB Deceased organ donor factors influencing pancreatic graft transplantation and survival. Sally MB, Ellis MK, Hutchens M, Groat T, Swanson E, Patel MS, Niemann CU, Malinoski DJ The Impact of Deceased Donor Liver Extraction Time on Early Allograft Function in Adult Liver Transplant Recipients. Adelmann D, Roll GR, Kothari R, Syed S, Burdine LJ, Tavakol M, Niemann CU Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy. Adelmann D, Olmos A, Liu LL, Feiner JR, Roll GR, Burdine L, Tavakol M, Syed S, Orandi BJ, Niemann CU Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis. Adelmann D, Bicknell L, Niemann CU, Feiner J, Roll GR, Burdine L, Whitlock EL Organ Donor Management: Part 1. Toward a Consensus to Guide Anesthesia Services During Donation After Brain Death. Souter MJ, Eidbo E, Findlay JY, Lebovitz DJ, Moguilevitch M, Neidlinger NA, Wagener G, Paramesh AS, Niemann CU, Roberts PR, Pretto EA Comments on "Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation". Niemann CU, Broglio K, Malinoski D Potentially inappropriate liver transplantation in the era of the "sickest first" policy - A search for the upper limits. Linecker M, Krones T, Berg T, Niemann CU, Steadman RH, Dutkowski P, Clavien PA, Busuttil RW, Truog RD, Petrowsky H Protecting the Kidney in Liver Transplant Recipients: Practice-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice. Levitsky J, O'Leary JG, Asrani S, Sharma P, Fung J, Wiseman A, Niemann CU Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function. Niemann CU, Malinoski D Impact of a quality improvement project on deceased organ donor management. Olmos A, Feiner J, Hirose R, Swain S, Blasi A, Roberts JP, Niemann CU Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function. Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP, Malinoski D Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement. Kotloff RM, Blosser S, Fulda GJ, Malinoski D, Ahya VN, Angel L, Byrnes MC, DeVita MA, Grissom TE, Halpern SD, Nakagawa TA, Stock PG, Sudan DL, Wood KE, Anillo SJ, Bleck TP, Eidbo EE, Fowler RA, Glazier AK, Gries C, Hasz R, Herr D, Khan A, Landsberg D, Lebovitz DJ, Levine DJ, Mathur M, Naik P, Niemann CU, Nunley DR, O'Connor KJ, Pelletier SJ, Rahman O, Ranjan D, Salim A, Sawyer RG, Shafer T, Sonneti D, Spiro P, Valapour M, Vikraman-Sushama D, Whelan TP, Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurem The Impact of Hydroxyethyl Starch Use in Deceased Organ Donors on the Development of Delayed Graft Function in Kidney Transplant Recipients: A Propensity-Adjusted Analysis. Patel MS, Niemann CU, Sally MB, De La Cruz S, Zatarain J, Ewing T, Crutchfield M, Enestvedt CK, Malinoski DJ A role for Rac1 activity in malignant progression of sebaceous skin tumors. Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C Exercise-induced changes in basal ganglia volume and cognition in older adults. Niemann C, Godde B, Staudinger UM, Voelcker-Rehage C Abdominal transplantation. Niemann CU Patients with chronic kidney disease. Kalamas AG, Niemann CU Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation. Parekh J, Roll GR, Feng S, Niemann CU, Hirose R Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy. Everson GT, Hoefs JC, Niemann CU, Olthoff KM, Dupuis R, Lauriski S, Herman A, Milne N, Gillespie BW, Goodrich NP, Everhart JE Deceased organ donor research: the last research frontier? Mone T, Heldens J, Niemann CU Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study. Wray C, Scovotti JC, Tobis J, Niemann CU, Planinsic R, Walia A, Findlay J, Wagener G, Cywinski JB, Markovic D, Hughes C, Humar A, Olmos A, Sierra R, Busuttil R, Steadman RH Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series. Behrends M, Niemann CU, Larson MD Optimizing cost-effectiveness in perioperative care for liver transplantation: a model for low- to medium-income countries. Rando K, Niemann CU, Taura P, Klinck J Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study. Parekh J, Niemann CU, Dang K, Hirose R Transplant critical care: standards for intensive care of the patient with liver failure before and after transplantation. Niemann CU, Kramer DJ Intraoperative management of liver transplant patients. Liu LL, Niemann CU Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model. Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantation. Yong CM, Sharma M, Ochoa V, Abnousi F, Roberts J, Bass NM, Niemann CU, Shiboski S, Prasad M, Tavakol M, Ports TA, Gregoratos G, Yeghiazarians Y, Boyle AJ Liver transplant perioperative pathways: which way towards high-quality care and better outcomes? Biancofiore G, Niemann CU Mapping the ionization state of laser-irradiated Ar gas jets with multiwavelength monochromatic x-ray imaging. Kugland NL, Döppner T, Kemp A, Schaeffer D, Glenzer SH, Niemann C 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit. Cohen MJ, Serkova NJ, Wiener-Kronish J, Pittet JF, Niemann CU Chronic kidney disease: implications for the perioperative period. Eilers H, Liu KD, Gruber A, Niemann CU Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats. Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU Quality improvement in transplant anesthesia: which way forward? Niemann CU, Feiner J Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ Evolution of elastic x-ray scattering in laser-shocked warm dense lithium. Kugland NL, Gregori G, Bandyopadhyay S, Brenner CM, Brown CR, Constantin C, Glenzer SH, Khattak FY, Kritcher AL, Niemann C, Otten A, Pasley J, Pelka A, Roth M, Spindloe C, Riley D Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats. Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, Hirose R Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin. Niemann CU, Walia A, Waldman J, Davio M, Roberts JP, Hirose R, Feiner J Abdominal organ transplantation. Niemann CU, Eilers H Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair. Chang CK, Chuter TA, Niemann CU, Shlipak MG, Cohen MJ, Reilly LM, Hiramoto JS Predictors associated with terminal renal function in deceased organ donors in the intensive care unit. Blasi-Ibanez A, Hirose R, Feiner J, Freise C, Stock PG, Roberts JP, Niemann CU Postoperative infectious complications of abdominal solid organ transplantation. Hlava N, Niemann CU, Gropper MA, Melcher ML High contrast Kr gas jet K alpha x-ray source for high energy density physics experiments. Kugland NL, Neumayer P, Döppner T, Chung HK, Constantin CG, Girard F, Glenzer SH, Kemp A, Niemann C Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA Perioperative liver transplant best practices: weighing the evidence. Mandell MS, Niemann CU Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU Green frequency-doubled laser-beam propagation in high-temperature hohlraum plasmas. Niemann C, Berger RL, Divol L, Froula DH, Jones O, Kirkwood RK, Meezan N, Moody JD, Ross J, Sorce C, Suter LJ, Glenzer SH Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model. Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU A multicenter evaluation of safety of early extubation in liver transplant recipients. Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofiore G, Niemann C, Walia A, Vater Y, Tran ZV, Kam I Remote renal injury following partial hepatic ischemia/reperfusion injury in rats. Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU Biochemical mechanisms of nephrotoxicity: application for metabolomics. Niemann CU, Serkova NJ Early detection of graft failure using the blood metabolic profile of a liver recipient. Serkova NJ, Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell MS Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury. Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D, Niemann CU Central venous pressure monitoring during living right donor hepatectomy. Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP Ischemia-reperfusion injury is more severe in older versus young rat livers. Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics. Serkova NJ, Niemann CU Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats. Noh J, Behrends M, Choi S, Bedolli MA, Yardi J, Hirose R, Niemann CU Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N Metabolic profiling of livers and blood from obese Zucker rats. Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean rats. Choi S, Noh J, Hirose R, Ferell L, Bedolli M, Roberts JP, Niemann CU Ischemic preconditioning improves rat kidney graft function after severe ischemia/reperfusion injury. Fuller TF, Freise CE, Feng S, Niemann CU Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution. Avram MJ, Krejcie TC, Henthorn TK, Niemann CU Intraoperative fluid management of living donor versus cadaveric liver transplant recipients. Niemann CU, Hirose R, Stock P, Roberts JP, Mandell S, Spencer Yost C Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts. Fuller TF, Serkova N, Niemann CU, Freise CE Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury. Fuller TF, Freise CE, Serkova N, Niemann CU, Olson JL, Feng S Mechanism of pupillary reflex dilation in awake volunteers and in organ donors. Yang LL, Niemann CU, Larson MD The effects of desflurane and propofol on portosystemic pressure in patients with portal hypertension. Mandell MS, Durham J, Kumpe D, Trotter JF, Everson GT, Niemann CU Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat. Serkova N, Klawitter J, Niemann CU Clinically important drug interactions with intravenous anaesthetics in older patients. Eilers H, Niemann C Intraoperative hemodynamics and liver function in adult-to-adult living liver donors. Niemann CU, Roberts JP, Ascher NL, Yost CS Elimination of indocyanine green in the perioperative evaluation of donor liver function. Mandell MS, Wachs M, Niemann CU, Henthorn TK Cyclosporine can increase isoflurane MAC. Niemann CU, Stabernack C, Serkova N, Jacobsen W, Christians U, Eger EI Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients. Niemann CU, Yost CS, Mandell S, Henthorn TK Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U Isoflurane alters the recirculatory pharmacokinetics of physiologic markers. Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective. Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ The effect of halothane on the recirculatory pharmacokinetics of physiologic markers. Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs. Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ
