Biography Art Wallace, M.D., Ph.D. is a professor and vice-chair of anesthesiology and perioperative care at the University of California, San Francisco and Chief of the Anesthesia Service at the Veterans Affairs Medical Center in San Francisco. His clinical practice includes cardiac and non-cardiac anesthesiology as well as ICU and preoperative clinical care. He completed a B.S. in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including device development for monitoring, surgical therapy of heart failure, and the off pump CABG, as well as drug development and testing. He is best known for his work developing medications for the prevention of perioperative cardiac morbidity and mortality. He was one of the developers of perioperative beta blockade and has assisted more than 200 hospitals set up perioperative beta blocker programs. His present work includes development medications to reduce perioperative cardiac risk, development of the ECOM cardiac output monitor, developing a non-invasive respiratory monitor, a device to provide electronic sedation, testing and development of surgical therapies for heart failure, implementation of perioperative beta blockade, developing therapies to prevent perioperative and ICU related PTSD, and developing computer systems to improve systems based medicine. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction. intelligence. Role Faculty Location VA Medical Center Category Clinical Research Education 2019 - Diversity, Equity, and Inclusion Champion Training, University of CaliforniaResidency, - School of Medicine, University of California, San Francisco Publications Preliminary Development and Validation of Automated Nociception Recognition Using Computer Vision in Perioperative Patients. Heintz TA, Badathala A, Wooten A, Cu CW, Wallace A, Pham B, Wallace AW, Cobert J Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study. Wallace AW, Cirillo PM, Ryan JC, Krigbaum NY, Badathala A, Cohn BA SARS-CoV-2 vaccine protection and deaths among US veterans during 2021. Cohn BA, Cirillo PM, Murphy CC, Krigbaum NY, Wallace AW A finite element model of the cardiac ventricles with coupled circulation: Biventricular mesh generation with hexahedral elements, airbags and a functional mockup interface to the circulation. Zhang Y, Adams J, Wang VY, Horwitz L, Tartibi M, Morgan AE, Kim J, Wallace AW, Weinsaft JW, Ge L, Ratcliffe MB Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression. Pennybaker S, Roach BJ, Fryer SL, Badathala A, Wallace AW, Mathalon DH, Marton TF A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction. Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe MB Sharing Lessons Learned to Prevent Adverse Events in Anesthesiology Nationwide. Soncrant C, Neily J, Sum-Ping SJT, Wallace AW, Mariano ER, Leissner KB, Mills PD, Mazzia L, Paull DE Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain. Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow. Brzezinski M, Dincheva GR, Alloo K, Wong C, Feng CM, Tom WL, Salahieh A, Wallace AW Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep. Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB Freedom From Opioids After Total Knee Arthroplasty. Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW Investigation of possible aqueous phase formation during vaporization of sevoflurane. Varughese S, Kalthod VG, Petzel JP, Bacher HP, Wallace AW E-cigarettes versus nicotine patches for perioperative smoking cessation: a pilot randomized trial. Lee SM, Tenney R, Wallace AW, Arjomandi M Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB Sevoflurane Contamination: Water Accumulation in Sevoflurane Vaporizers Can Allow Bacterial Growth in the Vaporizer. Wallace AW Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB In Reply. Lee SM, Takemoto S, Wallace AW Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System. Lee SM, Takemoto S, Wallace AW Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia. Mudumbai SC, Wagner T, Mahajan S, King R, Heidenreich PA, Hlatky M, Wallace AW, Mariano ER Thirty-day mortality risk associated with the postoperative nonresumption of angiotensin-converting enzyme inhibitors: a retrospective study of the Veterans Affairs Healthcare System. Mudumbai SC, Takemoto S, Cason BA, Au S, Upadhyay A, Wallace AW Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB Left ventricular pressure gating in ovine cardiac studies: a software-based method. Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB Risk of acute myocardial infarction in patients with total hip or knee replacement: comment on "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study". Wallace AW The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure. Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction. Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol. Wallace AW, Au S, Cason BA Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB Association of the pattern of use of perioperative β-blockade and postoperative mortality. Wallace AW, Au S, Cason BA First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB Clonidine and modification of perioperative outcome. Wallace AW The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB MRI-based finite-element analysis of left ventricular aneurysm. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Wallace AW, Galindez D, Salahieh A, Layug EL, Lazo EA, Haratonik KA, Boisvert DM, Kardatzke D Is it time to get on the fast track or stay on the slow track? Wallace AW Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure. Victal OA, Teerlink JR, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB
