Biography Dr. Xiaobing Yu is an anesthesiologist specialized in pain management. After Anesthesiology Residency at Brigham and Women's Hospital-Harvard Medical School, Dr. Yu completed fellowship in Pain Medicine at University of California San Francisco prior to his faculty appointment. He provides innovative interventional procedures guided by ultrasound or fluoroscopy (an imaging technique using continuous X-rays) to treat many chronic and persistent pain conditions. These include orofacial pain (such as trigeminal neuralgia), failed back surgery syndrome, facetogenic pain (involving the facet joints of the spine's vertebrae), neuropathic pain, complex regional pain syndrome and pain associated with cancer. Dr. Yu’s clinical background provides crucial insight into identifying research niche to improve patient care. Supported by the NIH, foundation grants, and intramural fundings, his research is focused on investigating the contribution of neuroimmune interaction between tissue resident immune cells and nociceptors to neuropathic diseases using both preclinical animal models and patient induced pluripotent stem cell (iPSC)-derived disease model. As a physician scientist, Dr. Yu is committed to inspiring brilliant, diverse trainees to pursue a career path to lead future academic medicine. He is the clerkship director of both Anes 140.06 and 130.01, and the director of resident chronic pain rotation. In addition to clinical mentoring, Dr. Yu has served as the research mentor of postdoctoral researchers, graduate students, NIH Diversity Supplement Award for predoctoral candidates, the Medical Student Anesthesia Research Fellowship, Pathway to Discovery Learner and Deep Explore Project. Role Faculty Location UCSF at Mission Bay Category Clinical Research Specialties Pain Medicine Education Fellowship, 2013 - Pain Medicine, UCSFResidency, 2012 - Anesthesiology, Harvard Medical School1994 - , Peking Union Medical College Publications Editorial: Microglia and tissue macrophages in pain. Mohsenin D, Yu J, Guan Z, Yu X Update on the medical management of fibrous dysplasia of the bone. Wentworth KL, Park J, Yu X, Hsiao EC Persistent postseptoplasty nasal neuropathic pain. Gemelga G, Chawla S, Sharma S, Yu X IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis. Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC Contribution of colony-stimulating factor 1 to neuropathic pain. Yu X, Basbaum A, Guan Z Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva. Khan F, Yu X, Hsiao EC Maxillary Nerve-Mediated Postseptoplasty Nasal Allodynia: A Case Report. Sharma S, Ly W, Yu X Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI Rapid Isolation of Dorsal Root Ganglion Macrophages. Yu X, Leff J, Guan Z Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. Peniche A, Poree L, Schumacher M, Yu X T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT Erythropoietin signaling promotes transplanted progenitor cell survival. Jia Y, Warin R, Yu X, Epstein R, Noguchi CT Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models. Pomper MG, Hammond H, Yu X, Ye Z, Foss CA, Lin DD, Fox JJ, Cheng L Id1 delays senescence of primary human melanocytes. Cummings SD, Ryu B, Samuels MA, Yu X, Meeker AK, Healey MA, Alani RM Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, Zou J, Cheng L Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. Alder JK, Georgantas RW, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L Lentiviral gene transduction of mouse and human stem cells. Ye Z, Yu X, Cheng L Hypoxia alters progression of the erythroid program. Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT Modification of globin gene expression by RNA targeting strategies. Shen TJ, Rogers H, Yu X, Lin F, Noguchi CT, Ho C FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Li L, Piloto O, Kim KT, Ye Z, Nguyen HB, Yu X, Levis M, Cheng L, Small D A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L Tal1/SCL binding to pericentromeric DNA represses transcription. Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. Dunlap S, Yu X, Cheng L, Civin CI, Alani RM Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L Erythropoietin receptor signalling is required for normal brain development. Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. Yu X, Lin CS, Costantini F, Noguchi CT Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT Production and processing of erythropoietin receptor transcripts in brain. Chin K, Yu X, Beleslin-Cokic B, Liu C, Shen K, Mohrenweiser HW, Noguchi CT
