Biography Dr. Xiaobing Yu is an anesthesiologist specialized in pain management. After Anesthesiology Residency at Brigham and Women's Hospital-Harvard Medical School, Dr. Yu completed fellowship in Pain Medicine at University of California San Francisco prior to his faculty appointment. He provides innovative interventional procedures guided by ultrasound or fluoroscopy (an imaging technique using continuous X-rays) to treat many chronic and persistent pain conditions. These include orofacial pain (such as trigeminal neuralgia), failed back surgery syndrome, facetogenic pain (involving the facet joints of the spine's vertebrae), neuropathic pain, complex regional pain syndrome and pain associated with cancer. Dr. Yu’s clinical background provides crucial insight into identifying research niche to improve patient care. Supported by the NIH, foundation grants, and intramural fundings, his research is focused on investigating the contribution of neuroimmune interaction between tissue resident immune cells and nociceptors to neuropathic diseases using both preclinical animal models and patient induced pluripotent stem cell (iPSC)-derived disease model. As a physician scientist, Dr. Yu is committed to inspiring brilliant, diverse trainees to pursue a career path to lead future academic medicine. He is the clerkship director of both Anes 140.06 and 130.01, and the director of resident chronic pain rotation. In addition to clinical mentoring, Dr. Yu has served as the research mentor of postdoctoral researchers, graduate students, NIH Diversity Supplement Award for predoctoral candidates, the Medical Student Anesthesia Research Fellowship, Pathway to Discovery Learner and Deep Explore Project. Role Faculty Location UCSF at Mission Bay Category Clinical Research Specialties Pain Medicine Education Fellowship, 2013 - Pain Medicine, UCSFResidency, 2012 - Anesthesiology, Harvard Medical School1994 - , Peking Union Medical College Publications Editorial: Microglia and tissue macrophages in pain. Mohsenin D, Yu J, Guan Z, Yu X . Frontiers in immunology . Aug 7, 2025 Update on the medical management of fibrous dysplasia of the bone. Wentworth KL, Park J, Yu X, Hsiao EC . Therapeutic advances in endocrinology and metabolism . Jun 18, 2025 Persistent postseptoplasty nasal neuropathic pain. Gemelga G, Chawla S, Sharma S, Yu X . Pain reports . Apr 3, 2025 IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis. Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM . Science immunology . Oct 13, 2023 ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC . Pain . Apr 20, 2022 Contribution of colony-stimulating factor 1 to neuropathic pain. Yu X, Basbaum A, Guan Z . Pain reports . Mar 9, 2021 Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva. Khan F, Yu X, Hsiao EC . Biomedicines . Feb 5, 2021 Maxillary Nerve-Mediated Postseptoplasty Nasal Allodynia: A Case Report. Sharma S, Ly W, Yu X . A&A practice . Nov 1, 2020 Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI . Nature communications . Jan 14, 2020 Rapid Isolation of Dorsal Root Ganglion Macrophages. Yu X, Leff J, Guan Z . Journal of visualized experiments : JoVE . Sep 7, 2019 Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. Peniche A, Poree L, Schumacher M, Yu X . A&A practice . Jun 1, 2018 T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT . The Journal of biological chemistry . Sep 16, 2012 Erythropoietin signaling promotes transplanted progenitor cell survival. Jia Y, Warin R, Yu X, Epstein R, Noguchi CT . FASEB journal : official publication of the Federation of American Societies for Experimental Biology . May 5, 2009 Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models. Pomper MG, Hammond H, Yu X, Ye Z, Foss CA, Lin DD, Fox JJ, Cheng L . Cell research . Mar 1, 2009 Id1 delays senescence of primary human melanocytes. Cummings SD, Ryu B, Samuels MA, Yu X, Meeker AK, Healey MA, Alani RM . Molecular carcinogenesis . Sep 1, 2008 Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, Zou J, Cheng L . Stem cells (Dayton, Ohio) . May 29, 2008 Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L . Cell stem cell . May 8, 2008 Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. Alder JK, Georgantas RW, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI . Journal of immunology (Baltimore, Md. : 1950) . Apr 15, 2008 Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L . Cell stem cell . Apr 10, 2008 Lentiviral gene transduction of mouse and human stem cells. Ye Z, Yu X, Cheng L . Methods in molecular biology (Clifton, N.J.) . Jan 1, 2008 Hypoxia alters progression of the erythroid program. Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT . Experimental hematology . Oct 22, 2007 Modification of globin gene expression by RNA targeting strategies. Shen TJ, Rogers H, Yu X, Lin F, Noguchi CT, Ho C . Experimental hematology . Aug 1, 2007 FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Li L, Piloto O, Kim KT, Ye Z, Nguyen HB, Yu X, Levis M, Cheng L, Small D . British journal of haematology . Apr 1, 2007 A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB . Nature genetics . Jan 9, 2007 HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI . Stem cells (Dayton, Ohio) . Mar 2, 2006 Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L . Stem cells (Dayton, Ohio) . Jul 7, 2005 Tal1/SCL binding to pericentromeric DNA represses transcription. Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT . The Journal of biological chemistry . Jan 27, 2005 Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD . Development (Cambridge, England) . Jul 27, 2004 Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT . Blood . Jun 17, 2004 High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. Dunlap S, Yu X, Cheng L, Civin CI, Alani RM . The Journal of investigative dermatology . Feb 1, 2004 Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L . Molecular therapy : the journal of the American Society of Gene Therapy . Jun 1, 2003 Erythropoietin receptor signalling is required for normal brain development. Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT . Development (Cambridge, England) . Jan 1, 2002 Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N . Blood cells, molecules & diseases . Nov 1, 2001 The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. Yu X, Lin CS, Costantini F, Noguchi CT . Blood . Jul 15, 2001 Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT . The Journal of biological chemistry . Dec 15, 2000 Production and processing of erythropoietin receptor transcripts in brain. Chin K, Yu X, Beleslin-Cokic B, Liu C, Shen K, Mohrenweiser HW, Noguchi CT . Brain research. Molecular brain research . Sep 30, 2000