Biography Currently, I hold the position of Professor of Anatomy within the HDF Comprehensive Cancer Center at UCSF. My research work delves into the involvement of TGFbeta signaling pathway components in vascular biology and cancer. I have also taken on the role of Principal Investigator in numerous research projects funded by the NIH, focusing on areas like vascular stability, cancer immunotherapy, and vascular pathobiology. As part of my ongoing work, I am an active participant in projects aimed at reducing cancer health disparities and furthering our understanding of cancer progression. This journey into discovery and understanding is ongoing and I am continually learning and expanding upon my research. Publications Diverse Biological Processes Contribute to Transforming Growth Factor ß-Mediated Cancer Drug Resistance. James P. Heiserman, Rosemary J. Akhurst Cells . Sep 28, 2025 Abstract A055: Dissecting mechanisms of tumor anti-PD1 resistance due to host genetic variation within ADAM17. James P Heiserman, Rosemary Akhurst, Tanuja Desai, Sharon Chen Cancer Immunology Research . Feb 23, 2025 Stem-cell states converge in multistage cutaneous squamous cell carcinoma development. Taylor MA, Kandyba E, Halliwill K, Delrosario R, Khoroshkin M, Goodarzi H, Quigley D, Li YR, Wu D, Bollam SR, Mirzoeva OK, Akhurst RJ, Balmain A Science (New York, N.Y.) . May 31, 2024 From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition. Akhurst RJ Seminars in cancer biology . Oct 16, 2023 Executive summary of the 14th HHT international scientific conference. Ola R, Hessels J, Hammill A, Friday C, Clancy M, Al-Samkari H, Meadows S, Iyer V, Akhurst R Angiogenesis . Sep 11, 2023 Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis. Taylor MA, Kandyba E, Halliwill K, Delrosario R, Koroshkin M, Goodarzi H, Quigley D, Li YR, Wu D, Bollam S, Mirzoeva O, Akhurst RJ, Balmain A bioRxiv : the preprint server for biology . May 10, 2023 Abstract 3420: Tgfbm3b is a natural germline genetic variant that modifies anti-tumor responses to anti-PD-1 immunotherapy through its action on the tumor microenvironment. Szu-Ying Chen, Ons Mamai, Rosemary Akhurst Cancer research . Jun 15, 2022 Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients. Griffin L, Ho L, Akhurst RJ, Arron ST, Boggs JME, Conlon P, O'Kelly P, Toland AE, Epstein EH, Balmain A, Bastian BC, Moloney FJ, Murphy GM, Laing ME Skin health and disease . Feb 2, 2022 TGFβ: Signaling Blockade for Cancer Immunotherapy. Chen SY, Mamai O, Akhurst RJ Annual review of cancer biology . Dec 22, 2021 Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D Cell reports . Jul 6, 2021 TGFβ biology in cancer progression and immunotherapy. Derynck R, Turley SJ, Akhurst RJ Nature reviews. Clinical oncology . Jul 24, 2020 α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas. Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ Journal for immunotherapy of cancer . Mar 4, 2019 Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R Science signaling . Feb 26, 2019 Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R iScience . Jan 3, 2019 From prevention to cure, repurposing anti-viral vaccines for cancer immunotherapy. Mamai O, Dodagatta-Marri E, Akhurst RJ Biotarget . Dec 1, 2018 Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R EMBO reports . Dec 12, 2017 Targeting TGF-β Signaling for Therapeutic Gain. Akhurst RJ Cold Spring Harbor perspectives in biology . Oct 3, 2017 ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R PLoS biology . Dec 17, 2015 Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma. Megan Murnane, Eugen Dhimolea, Ruojing Li, Megan A. Bariteau, Diamond D. Wheeler, Rosemary J. Akhurst, Aaron C. Logan, Pamela Munster, Arun Wiita, Thomas G. Martin, Jeffrey L. Wolf, Jun O. Liu, Constantine S. Mitsiades, Blake T. Aftab Blood . Dec 3, 2015 Matters of context guide future research in TGFβ superfamily signaling. Akhurst RJ, Padgett RW Science signaling . Oct 20, 2015 Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14. Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ Frontiers in genetics . Mar 12, 2015 Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF Development (Cambridge, England) . Nov 18, 2014 Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans. Kawasaki K, Freimuth J, Meyer DS, Lee MM, Tochimoto-Okamoto A, Benzinou M, Clermont FF, Wu G, Roy R, Letteboer TG, Ploos van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Westermann CJ, Coffey RJ, Akhurst RJ Proceedings of the National Academy of Sciences of the United States of America . May 8, 2014 BMP-9 balances endothelial cell fate. Derynck R, Akhurst RJ Proceedings of the National Academy of Sciences of the United States of America . Nov 12, 2013 Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A The Journal of investigative dermatology . Jan 28, 2013 Erratum: Targeting the TGFß signalling pathway in disease. Rosemary J. Akhurst, Akiko Hata Nature Reviews Drug Discovery . Nov 1, 2012 Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ Proceedings of the National Academy of Sciences of the United States of America . Oct 11, 2012 Targeting the TGFβ signalling pathway in disease. Akhurst RJ, Hata A Nature reviews. Drug discovery . Sep 24, 2012 The paradoxical TGF-β vasculopathies. Akhurst RJ Nature genetics . Jul 27, 2012 Complexities of TGF-β targeted cancer therapy. Connolly EC, Freimuth J, Akhurst RJ International journal of biological sciences . Jul 12, 2012 TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. S. Lamouille, E. Connolly, J. W. Smyth, R. J. Akhurst, R. Derynck Development . May 15, 2012 TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R Journal of cell science . Mar 1, 2012 Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β. Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF The Journal of neuroscience : the official journal of the Society for Neuroscience . Jan 25, 2012 Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Benzinou M, Clermont FF, Letteboer TG, Kim JH, Espejel S, Harradine KA, Arbelaez J, Luu MT, Roy R, Quigley D, Higgins MN, Zaid M, Aouizerat BE, van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Plauchu H, Hughes CC, Westermann CJ, Akhurst RJ Nature communications . Jan 10, 2012 Erratum: Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Michael Benzinou, Frederic F. Clermont, Tom G W. Letteboer, Jai-hyun Kim, Silvia Espejel, Kelly A. Harradine, Juan Arbelaez, Minh Thu Luu, Ritu Roy, David Quigley, Mamie Nakayama Higgins, Musa Zaid, Bradley E. Aouizerat, Johannes Kristian Ploos van Amstel, Sophie Giraud, Sophie Dupuis-Girod, Gaetan Lesca, Henri Plauchu, Christopher C W. Hughes, Cornelius J.J. Westermann, Rosemary J. Akhurst Nature communications . Jan 1, 2012 The complexities of TGF-β action during mammary and squamous cell carcinogenesis. Connolly EC, Akhurst RJ Current pharmaceutical biotechnology . Dec 1, 2011 TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH Clinical cancer research : an official journal of the American Association for Cancer Research . Oct 25, 2011 Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761. Connolly EC, Saunier EF, Quigley D, Luu MT, De Sapio A, Hann B, Yingling JM, Akhurst RJ Cancer research . Jan 31, 2011 Taking thalidomide out of rehab. Akhurst RJ Nature Medicine . Apr 1, 2010 Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients. Harradine KA, Ridd K, Saunier EF, Clermont FF, Perez-Losada J, Moore DH, Epstein EH, Bastian BC, Akhurst RJ Clinical cancer research : an official journal of the American Association for Cancer Research . Aug 11, 2009 Transforming growth factor-beta in breast cancer: too much, too late. Barcellos-Hoff MH, Akhurst RJ Breast cancer research : BCR . Feb 26, 2009 The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Kang JS, Saunier EF, Akhurst RJ, Derynck R Nature cell biology . May 11, 2008 Reversal of EMT by Small-Molecule Inhibitors of TGF-ß Type I and II Receptors: Implications for Carcinoma Treatment. Markus D. Lacher, W. Michael Korn, Rosemary J. Akhurst Transforming Growth Factor-ß in Cancer Therapy, Volume II . Jan 1, 2008 Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Derynck R, Akhurst RJ Nature cell biology . Sep 1, 2007 Characterization of Tgfbm2, a genetic modifier of Tgfb1-/- embryonic lethality. Frederic Clermont, Minh Thu Luu, Mamie Higgins, Rosemary J Akhurst The FASEB Journal . Jan 1, 2007 TGF beta inhibition for cancer therapy. Saunier EF, Akhurst RJ Current cancer drug targets . Nov 1, 2006 Large- and small-molecule inhibitors of transforming growth factor-beta signaling. Akhurst RJ Current opinion in investigational drugs (London, England : 2000) . Jun 1, 2006 Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ Proceedings of the National Academy of Sciences of the United States of America . May 15, 2006 A sweet link between TGFbeta and vascular disease? Akhurst RJ Nature genetics . Apr 1, 2006 Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM Cancer research . Feb 1, 2006 TGFbeta inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development. Poon E, Clermont F, Firpo MT, Akhurst RJ Journal of cell science . Jan 31, 2006 Mutations of TGFbeta signaling molecules in human disease. Harradine KA, Akhurst RJ Annals of medicine . Jan 1, 2006 Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis. Tang Y, Lee KS, Yang H, Logan DW, Wang S, McKinnon ML, Holt LJ, Condie A, Luu MT, Akhurst RJ Genomics . Jan 1, 2005 TGF beta signaling in health and disease. Akhurst RJ Nature genetics . Aug 1, 2004 Cancer: dangerous liaisons. Balmain A, Akhurst RJ Nature . Mar 18, 2004 Mouse strain-dependent heterogeneity of resting limbal vasculature. Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton DR Investigative ophthalmology & visual science . Feb 1, 2004 Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice. Tang Y, McKinnon ML, Leong LM, Rusholme SA, Wang S, Akhurst RJ Human molecular genetics . Jul 1, 2003 Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH Cancer research . Oct 15, 2002 Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Oft M, Akhurst RJ, Balmain A Nature cell biology . Jul 1, 2002 Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH The American journal of pathology . Jun 1, 2002 TGF-beta antagonists: why suppress a tumor suppressor? Akhurst RJ The Journal of clinical investigation . Jun 1, 2002 TGF-beta signaling in cancer--a double-edged sword. Akhurst RJ, Derynck R Trends in cell biology . Nov 1, 2001 TGF-ß signaling in cancer — a double-edged sword. Rosemary J. Akhurst, Rik Derynck Trends in cell biology . Nov 1, 2001 TGF-beta signaling in tumor suppression and cancer progression. Derynck R, Akhurst RJ, Balmain A Nature genetics . Oct 1, 2001 Isolation, identification, and molecular characterization of strains of Photorhabdus luminescens from infected humans in Australia. Peel MM, Alfredson DA, Gerrard JG, Davis JM, Robson JM, McDougall RJ, Scullie BL, Akhurst RJ Journal of clinical microbiology . Nov 1, 1999 Genetic events and the role of TGF beta in epithelial tumour progression. Akhurst RJ, Balmain A The Journal of pathology . Jan 1, 1999 Epithelial carcinogenesis in the mouse: correlating the genetics and the biology. Frame S, Crombie R, Liddell J, Stuart D, Linardopoulos S, Nagase H, Portella G, Brown K, Street A, Akhurst R, Balmain A Philosophical transactions of the Royal Society of London. Series B, Biological sciences . Jun 29, 1998 Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Portella G, Cumming SA, Liddell J, Cui W, Ireland H, Akhurst RJ, Balmain A Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research . May 1, 1998 Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Bonyadi M, Rusholme SA, Cousins FM, Su HC, Biron CA, Farrall M, Akhurst RJ Nature genetics . Feb 1, 1997 TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, Akhurst RJ Cell . Aug 23, 1996 Altered epidermal cell growth control in vivo by inducible expression of transforming growth factor beta 1 in the skin of transgenic mice. Fowlis DJ, Cui W, Johnson SA, Balmain A, Akhurst RJ Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research . May 1, 1996 The TGF beta type II receptor, Tgfbr2, maps to distal mouse chromosome 9. Bonyadi M, Cui W, Nagase H, Akhurst RJ Genomics . Apr 15, 1996 The role of transforming growth factor ß during cardiovascular development. Marion C. Dickson, Julie S. Martin, Rosemary J. Akhurst Molecular Physiology of Growth . Jan 1, 1996 Transforming growth factor ßS: Biochemistry and biological activities in vitro and in vivo. Wei Cui, Rosemary J. Akhurst Growth Factors . Jan 1, 1996 Liposome-medicated gene transfer and expression via the skin. Alexander MY, Akhurst RJ Human molecular genetics . Dec 1, 1995 Circulating human factor IX produced in keratin-promoter transgenic mice: a feasibility study for gene therapy of haemophilia B. Alexander MY, Bidichandani SI, Cousins FM, Robinson CJ, Duffie E, Akhurst RJ Human molecular genetics . Jun 1, 1995 Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ Development (Cambridge, England) . Jun 1, 1995 Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Cui W, Fowlis DJ, Cousins FM, Duffie E, Bryson S, Balmain A, Akhurst RJ Genes & development . Apr 15, 1995 Analysis of homozygous TGF beta 1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis. Martin JS, Dickson MC, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ Annals of the New York Academy of Sciences . Mar 27, 1995 Lack of transforming growth factor-beta 1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion. Cui W, Kemp CJ, Duffie E, Balmain A, Akhurst RJ Cancer research . Nov 15, 1994 Localization of transforming growth factor-alpha RNA and protein in the skin of psoriatic patients receiving therapy. Watts P, Stables GS, Akhurst RJ, Mackie RM The British journal of dermatology . Jul 1, 1994 Physical methods of gene delivery using keratinocytes as a target for somatic cell gene therapy. Alexander MY, Bidichandani S, Robinson C, Trainer AH, Akhurst RJ Gene therapy . Jan 1, 1994 Localization of growth factor mRNA in tissue sections by in situ hybridization. Rosemary J Akhurst Growth Factors . Mar 4, 1993 RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development. Dickson MC, Slager HG, Duffie E, Mummery CL, Akhurst RJ Development (Cambridge, England) . Feb 1, 1993 Positive and negative growth control in multistage skin carcinogenesis. Brown K, Kemp CJ, Burns PA, Stoler AB, Fowlis DJ, Akhurst RJ, Balmain A Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer . Jan 1, 1993 Rapid induction and clearance of TGF beta 1 is an early response to wounding in the mouse embryo. Martin P, Dickson MC, Millan FA, Akhurst RJ Developmental genetics . Jan 1, 1993 Transforming growth factor ßs and cardiac development. Rosemary J. Akhurst, Marion Dickson, Fergus A. Millan Growth Factors and the Cardiovascular System . Jan 1, 1993 The role of TGF-beta s in mammalian development and neoplasia. Akhurst RJ, Fitzpatrick DR, Fowlis DJ, Gatherer D, Millan FA, Slager H Molecular reproduction and development . Jun 1, 1992 Palatal expression of TGF-ß isoforms in normal and retinoic acid-treated mouse embryos. David R FitzPatrick, Barbara D Abbott, Rosemary J Akhurst Retinoids in Normal Development and Teratogenesis . May 21, 1992 Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin. Fowlis DJ, Flanders KC, Duffie E, Balmain A, Akhurst RJ Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research . Feb 1, 1992 Enormous scope for further research peptide growth factors and their receptors vol. I (1990). Edited by M. B. Sporn and A. B. Roberts. Springer-Verlag: Berlin. 785pp. DM 398. ISBN 3 540 51184 9. Rosemary Akhurst BioEssays . Feb 1, 1992 Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation. Haddow S, Fowlis DJ, Parkinson K, Akhurst RJ, Balmain A Oncogene . Aug 1, 1991 Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Millan FA, Denhez F, Kondaiah P, Akhurst RJ Development (Cambridge, England) . Jan 1, 1991 Functional loss of tumour suppressor genes in multistage chemical carcinogenesis. Balmain A, Kemp CJ, Burns PA, Stoler AB, Fowlis DJ, Akhurst RJ Princess Takamatsu symposia . Jan 1, 1991 Expression of TGF-beta isoforms during first trimester human embryogenesis. Gatherer D, Ten Dijke P, Baird DT, Akhurst RJ Development (Cambridge, England) . Oct 1, 1990 Localization of elevated transforming growth factor-alpha in psoriatic epidermis. Turbitt ML, Akhurst RJ, White SI, MacKie RM The Journal of investigative dermatology . Aug 1, 1990 Differential expression of TGF beta isoforms in murine palatogenesis. Fitzpatrick DR, Denhez F, Kondaiah P, Akhurst RJ Development (Cambridge, England) . Jul 1, 1990 TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Akhurst RJ, Lehnert SA, Faissner A, Duffie E Development (Cambridge, England) . Apr 1, 1990 The role of TGF beta in mouse development. Akhurst RJ, Lehnert SA, Gatherer D, Duffie E Annals of the New York Academy of Sciences . Jan 1, 1990 Transforming growth factor betas in mammalian embryogenesis. Akhurst RJ, FitzPatrick DR, Gatherer D, Lehnert SA, Millan FA Progress in growth factor research . Jan 1, 1990 The role of transforming growth factor-ß in mouse development and carcinogenesis. ROSEMARY J. AKHURST, SIGRID A. LEHNERT, FRANCES FEE, ALLAN BALMAIN Biochemical Society Transactions . Jun 1, 1989 Chemical induction of oncogene mutations and growth factor activity in mouse skin carcinogenesis. Bailleul B, Brown K, Ramsden M, Akhurst RJ, Fee F, Balmain A Environmental health perspectives . May 1, 1989 Intracellular localisation and expression of mammalian CDC2 protein during myogenic differentiation. Akhurst RJ, Flavin NB, Worden J, Lee MG Differentiation; research in biological diversity . Mar 1, 1989 Prospects for Gene Therapy Now and in the Future. R. J. Akhurst Studies in Inherited Metabolic Disease . Jan 1, 1989 Prospects for gene therapy now and in the future. Akhurst RJ Journal of inherited metabolic disease . Jan 1, 1989 The action of oncogenes and growth factors in tumour initiation and promotion. Akhurst R, Bailleul B, Brown K, Ramsden M, Fee F, Balmain A Carcinogenesis; a comprehensive survey . Jan 1, 1989 Molecular analysis of chemical carcinogenesis in the skin. Balmain A, Brown K, Akhurst RJ, Fee FM The British journal of cancer. Supplement . Dec 1, 1988 Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes. Bonduelle ML, Dodd R, Liebaers I, Van Steirteghem A, Williamson R, Akhurst R Human reproduction (Oxford, England) . Oct 1, 1988 Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action. Lehnert SA, Akhurst RJ Development (Cambridge, England) . Oct 1, 1988 Isolation and Characterization of a Variant Myoblast Cell Line That is Temperature Sensitive for Differentiation. Rosemary J. Akhurst, Nora B. Flavin, Jenny Worden Molecular and cellular biology . Jun 1, 1988 Isolation and characterization of a variant myoblast cell line that is temperature sensitive for differentiation. Akhurst RJ, Flavin NB, Worden J Molecular and cellular biology . Jun 1, 1988 Isolation and characterization of a variant myoblast cell line that is temperature sensitive for differentiation. R J Akhurst, N B Flavin, J Worden Molecular and cellular biology . Jun 1, 1988 Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Akhurst RJ, Fee F, Balmain A Nature . Jan 28, 1988 Sea urchin actin gene linkages determined by genetic segregation. Minor JE, Lee JJ, Akhurst RJ, Leahy PS, Britten RJ, Davidson EH Developmental biology . Jul 1, 1987 Structure and organization of the CyIII actin gene subfamily of the sea urchin, Strongylocentrotus purpuratus. Akhurst RJ, Calzone FJ, Lee JJ, Britten RJ, Davidson EH Journal of molecular biology . Mar 20, 1987 The use of gene probes in studying human reproduction and embryology. Akhurst RJ Human reproduction (Oxford, England) . Jun 1, 1986 Sea urchin actin gene subtypes. Gene number, linkage and evolution. Lee JJ, Shott RJ, Rose SJ, Thomas TL, Britten RJ, Davidson EH Journal of molecular biology . Jan 15, 1984 Dev. Biol Akhurst RJ (Shott RJ) Lee JJ, Britten RJ, Davidson EH Differential expression of the actin gene family of Strongylocentrotus purpuratus . Jan 1, 1984 Regulation of the relative abundances of mRNAs in hepatoma and liver. Birnie GD, Jacobs H, Shott R, Wilkes PR Advances in experimental medicine and biology . Jan 1, 1982 Post-transcriptional control of messenger abundance. Birnie GD, Balmain A, Jacobs H, Shott R, Wilkes PR, Paul J Molecular biology reports . May 22, 1981
