Publications Mesenchymal progenitor-derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing. Ninkovic N, Corpuz JM, Stahl A, Olsen A, Unger CM, Ardebili AA, Sun H, Cha J, Kaketsis D, Manske SL, Haider IT, Marcucio RS, Schmidt TA, Jay GD, Underhill TM, Edwards WB, Rancourt DE, Biernaskie J, Krawetz RJ Influence of Age on Fracture Healing in Young and Middle-Aged Mice in a Proximal Femur Fracture Model. Schmid T, Kanewska A, Lam C, Kalbitz M, Dieterich S, Ignatius A, Riegger J, Giger NV, Wehrle E, Marcucio RS, Miclau T, Haffner-Luntzer M Ultrafine-Grained Materials With Antibacterial Properties: A Novel Approach to Reducing Spinal Implant-Associated Infections. Nishizawa M, Hu D, Serhan H, Saleh B, Marcucio RS, Morioka K A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess. Nishizawa M, Saleh B, Marcucio R, Morioka K A bad break: mechanisms and assessment of acute and chronic pain after bone fracture. Nishimura H, Layne J, Yamaura K, Marcucio R, Morioka K, Basbaum AI, Weinrich JAP, Bahney CS PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms. Mok CH, Hu D, Losa M, Risolino M, Selleri L, Marcucio RS Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face. Hanne N, Hu D, Vidal-García M, Allen C, Shakir MB, Liu W, Hallgrímsson B, Marcucio R Quantifying the relationship between cell proliferation and morphology during development of the face. Lo Vercio LD, Green RM, Dauter A, Barretto EC, Vidal-García M, Devine J, Marchini M, Robertson S, Zhao X, Mahika A, Shakir MB, Guo S, Boughner JC, Szabo-Rogers H, Dean W, Lander AD, Marcucio RS, Forkert ND, Hallgrímsson B CD47 is required for mesenchymal progenitor proliferation and fracture repair. Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick L, Lam C, Schmanski JT, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face. Hanne N, Hu D, Vidal-García M, Allen C, Shakir MB, Liu W, Hallgrímsson B, Marcucio R PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms. Mok CH, Hu D, Losa M, Risolino M, Selleri L, Marcucio RS Age-related changes to macrophage subpopulations and TREM2 dysregulation characterize attenuated fracture healing in old mice. Clark D, Brazina S, Miclau T, Park S, Hsieh CL, Nakamura M, Marcucio R Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune Response. Duke VR, Philippon MJ, Lind DRG, Kasler H, Yamaura K, Huard M, Czachor M, Hollenbeck J, Brown J, Garcia A, Fukase N, Marcucio RS, Nelson AL, Hambright WS, Snapper DM, Huard J, Bahney CS β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model. Nelson AL, Mancino C, Gao X, Choe JA, Chubb L, Williams K, Czachor M, Marcucio R, Taraballi F, Cooke JP, Huard J, Bahney C, Ehrhart N Genetic architecture of trait variance in craniofacial morphology. Andrade F, Howell L, Percival CJ, Richtsmeier JT, Marcucio RS, Hallgrímsson B, Cheverud JM CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair. Hankenson K, Zondervan R, Capobianco C, Jenkins D, Reicha J, Frederick L, Lam C, Isenberg J, Ahn J, Marcucio RS CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair. Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick LM, Lam C, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses. Richbourg HA, Vidal-García M, Brakora KA, Devine J, Takenaka R, Young NM, Gong SG, Neves A, Hallgrímsson B, Marcucio RS Chapter 5 Macrophages in tissue engineering and regeneration. Dan Clark, Mary Nakamura, Theodore Miclau, Ralph Marcucio Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B The Developmental Basis for Evolvability. Benedikt Hallgrímsson, J. David Aponte, Marta Vidal-Garcia, Heather Richbourg, Rebecca Green, Nathan M. Young, James M. Cheverud, Anne L. Calof, Arthur D. Lander, Ralph S. Marcucio Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair. Rivera KO, Cuylear DL, Duke VR, O'Hara KM, Zhong JX, Elghazali NA, Finbloom JA, Kharbikar BN, Kryger AN, Miclau T, Marcucio RS, Bahney CS, Desai TA Quantifying the relationship between cell proliferation and morphology during development of the face. Green RM, Lo Vercio LD, Dauter A, Barretto EC, Devine J, Vidal-García M, Marchini M, Robertson S, Zhao X, Mahika A, Shakir MB, Guo S, Boughner JC, Dean W, Lander AD, Marcucio RS, Forkert ND, Hallgrímsson B Altered early immune response after fracture and traumatic brain injury. Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair. Marcucio RS, Miclau T, Bahney CS Segmentation of Tissues and Proliferating Cells in Light-Sheet Microscopy Images of Mouse Embryos Using Convolutional Neural Networks. Lo Vercio LD, Green RM, Robertson S, Guo S, Dauter A, Marchini M, Vidal-GARCíA M, Zhao X, Mahika A, Marcucio RS, HALLGRíMSSON B, Forkert ND Age-related decrease in periostin expression may be associated with attenuated fracture healing in old mice. Clark D, Doelling J, Hu D, Miclau T, Nakamura M, Marcucio R Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor. Lackner I, Weber B, Pressmar J, Odwarka A, Lam C, Haffner-Luntzer M, Marcucio R, Miclau T, Kalbitz M Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships. Zbasnik N, Dolan K, Buczkowski SA, Green RM, Hallgrímsson B, Marcucio RS, Moon AM, Fish JL MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B Developmental Morphospace of Embryonic Brain and Face Growth in the Chicken (Gallus gallus). Zuzana Vavrušová, Diane Hu, Wei Liu, Ralph S. Marcucio, Benedikt Hallgrímsson, Nathan M. Young Downstream Branches of the Fibroblast Growth Factor Signaling Pathway Act Interdependently to Shape the Face. Nicholas J. Hanne, Diane Hu, Charlie Allen, Bilal Shakir, Wei Liu, Benedikt Hallgrímsson, Ralph Marcucio Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape. Aponte JD, Katz DC, Roth DM, Vidal-García M, Liu W, Andrade F, Roseman CC, Murray SA, Cheverud J, Graf D, Marcucio RS, Hallgrímsson B Extracellular Matrix Composition Is Altered Alongside Dysmorphology in the Developing Palate. Nicholas Hanne, Diane Hu, Marta Linde-Medina, Marta Marchini, Benedikt Hallgrímsson, Ralph Marcucio Integration of Cellular Dynamics and Morphology to Understand Mouse Facial Development. Rebecca Green, Lucas Lo Vercio, Andreas Dauter, Si Han Guo, Samuel Robertson, Marta Marchini, Marta Vidal Garcia, Xiang Zhao, Ralph Marcucio, Nils Forkert, Benedikt Hallgrimsson Mapping the Multi-Modal Distribution of Craniofacial Phenotypes in NOSIP Mutants. Heather Richbourg, Rebecca Green, Jay Devine, Marta Vidal Garcia, Benedikt Hallgrimsson, Ralph Marcucio The Contribution of Macrophages in Old Mice to Periodontal Disease. Clark D, Halpern B, Miclau T, Nakamura M, Kapila Y, Marcucio R Wnt Signaling Drives Correlated Changes in Facial Morphology and Brain Shape. Marchini M, Hu D, Lo Vercio L, Young NM, Forkert ND, Hallgrímsson B, Marcucio R Systemic and local cardiac inflammation after experimental long bone fracture, traumatic brain injury and combined trauma in mice. Lackner I, Weber B, Haffner-Luntzer M, Hristova S, Gebhard F, Lam C, Morioka K, Marcucio RS, Miclau T, Kalbitz M Creating Avian Forebrain Chimeras to assess Facial Development. Hu D, Marcucio RS Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion. Rivera KO, Russo F, Boileau RM, Tomlinson RE, Miclau T, Marcucio RS, Desai TA, Bahney CS Chondrocyte-to-osteoblast transformation in mandibular fracture repair. Wong SA, Hu DP, Slocum J, Lam C, Nguyen M, Miclau T, Marcucio RS, Bahney CS A novel mouse model to study fracture healing at the proximal femur. Melanie Haffner-Luntzer, Birte Weber, Charles Lam, Verena Fischer, Miriam Kalbitz, Anita Ignatius, Ralph S. Marcucio, Theodore Miclau Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities. Panoutsopoulos AA, De Crescenzo AH, Lee A, Lu AM, Ross AP, Borodinsky LN, Marcucio R, Trainor PA, Zarbalis KS miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development. Richbourg HA, Hu DP, Xu Y, Barczak AJ, Marcucio RS A Registration and Deep Learning Approach to Automated Landmark Detection for Geometric Morphometrics. Devine J, Aponte JD, Katz DC, Liu W, Lo Vercio LD, Forkert ND, Marcucio R, Percival CJ, Hallgrímsson B Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M Biomedical research models in the science of fracture healing - Pitfalls & promises. Marmor MT, Dailey H, Marcucio R, Hunt AC Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes. Katz DC, Aponte JD, Liu W, Green RM, Mayeux JM, Pollard KM, Pomp D, Munger SC, Murray SA, Roseman CC, Percival CJ, Cheverud J, Marcucio RS, Hallgrímsson B A novel mouse model to study fracture healing of the proximal femur. Haffner-Luntzer M, Weber B, Lam C, Fischer V, Lackner I, Ignatius A, Kalbitz M, Marcucio RS, Miclau T Determining the Role of Extracellular Matrix Compliance on Facial Morphogenesis. Nicholas Jean Hanne, Diane Hu, Marta Linde-Medina, Benedikt Hallgrimsson, Ralph S. Marcucio Late embryonic skull anomalies in mice carrying the Fgfr2 W290R Crouzon mutation. M. Kathleen Pitirri, Susan M. Motch Perrine, Risa Takenaka, Ralph Marcucio, Joan Richtsmeier Mapping the Multi-Modal Distribution of Craniofacial Phenotypes in NOSIP Mutants. Heather A. Richbourg, Alexa Saliou, Jay Devine, Rebecca Green, Meike Hoffmeister, Stefanie Oess, Benedikt Hallgrimsson, Ralph Marcucio Mapping the relationship between proliferation and morphology in the developing mouse face. Rebecca M. Green, Lucas Lo Vercio, Sihan Guo, Andreas Dauter, Marta Marchini, Xiang Xhao, Ralph S. Marcucio, Benedikt Hallgrimsson Regulatory Dynamics of Midfacial Growth in Evolution and Disease. Licia Selleri, Ian Welsh, Karissa Hansen, Marco Osterwalder, Marta Losa-Llabata, Julie Wells, Carol Bult, Timothy Mohun, Diane Hu, Ralph Marcucio, Axel Visel, Tomek Swigut Age-related changes to macrophages are detrimental to fracture healing in mice. Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation. Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING. Daniel Clark, Theodore Miclau, Mary Nakamura, Ralph Marcucio Integration and the Developmental Genetics of Allometry. Hallgrímsson B, Katz DC, Aponte JD, Larson JR, Devine J, Gonzalez PN, Young NM, Roseman CC, Marcucio RS Nonlinear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse. Green RM, Leach CL, Diewert VM, Aponte JD, Schmidt EJ, Cheverud JM, Roseman CC, Young NM, Marcucio RS, Hallgrimsson B Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS Fracture repair in the elderly: Clinical and experimental considerations. Meinberg EG, Clark D, Miclau KR, Marcucio R, Miclau T Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling. Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO Emergent Properties of Facial Morphogenesis Regulated by Fgf Signaling. Ralph Marcucio, Diane Hu, Benedikt Hallgrimsson, Nathan Young Integration and the genetics of variation in facial shape. Benedikt Hallgrimsson, Jose David Aponte, David C Katz, Jordan J Bannister, Rebecca M Green, Nathan M Young, James M Cheverud, Nils Daniel Forkert, Ralph S Marcucio Modeling the Development of Cleft Lip and Palate in Variable Clefting Mouse Strains. Rebecca M. Green, Courtney L. Leach, Sihan Guo, Virginia Diewert, Ralph S. Marcucio, Benedikt Hallgrimsson The Silent Treatment: miR199 Family Silences Shh during Craniofacial Development. Heather Ashley Richbourg, Diane Hu, Ralph Marcucio The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA Cellular biology of fracture healing. Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD The developmental-genetics of canalization. Hallgrimsson B, Green RM, Katz DC, Fish JL, Bernier FP, Roseman CC, Young NM, Cheverud JM, Marcucio RS Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering. Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS The Society for Craniofacial Genetics and Developmental Biology 40th annual meeting. Gammill L, Cox T, Moody S, Taneyhill L, Trainor P, Marcucio R Quantifying the Genotype to Phenotype Map in Developing Mice. Heather A Richbourg, Nathan Young, Risa Takenaka, Ralph Marcucio Understanding the development of variable craniofacial phenotypes caused by altered methylation affecting Wnt9b in A-strain mice. Rebecca M. Green, Courtney L. Leach, Eric Schmidt, Virginia Diewert, Ralph S. Marcucio, Benedikt Hallgrimsson Untangling Sources of Phenotypic Variation Characterizing the Craniofacial Disease Holoprosencephaly. Alexis Lainoff, Nathan Young, Benedikt Hallgrimsson, Ralph Marcucio Simulation enabled search for explanatory mechanisms of the fracture healing process. Kennedy RC, Marmor M, Marcucio R, Hunt CA Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis. Linde-Medina M, Marcucio R Developmental constraint through negative pleiotropy in the zygomatic arch. Percival CJ, Green R, Roseman CC, Gatti DM, Morgan JL, Murray SA, Donahue LR, Mayeux JM, Pollard KM, Hua K, Pomp D, Marcucio R, Hallgrímsson B Developmental nonlinearity drives phenotypic robustness. Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrímsson B Effects of Aging on Fracture Healing. Clark D, Nakamura M, Miclau T, Marcucio R Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering. Marcucio RS, Qin L, Alsberg E, Boerckel JD Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T Fgf8 dosage and tissue interactions contribute to jaw asymmetry in disease. Jennifer L. Fish, Katie Dolan, Rebecca Green, Ralph S Marcucio, Benedikt Hallgrimsson QTL Analysis of a Trade-off in Bone Length within the Mouse Zygomatic Arch. Christopher J. Percival, Rebecca Green, Daniel M. Gatti, Daniel Pomp, Charles C. Roseman, Ralph Marcucio, Benedikt Hallgrímsson Shaping the sound of voice. Marcucio R Craniofacial diversification in the domestic pigeon and the evolution of the avian skull. Young NM, Linde-Medina M, Fondon JW, Hallgrímsson B, Marcucio RS Quantifying three-dimensional morphology and RNA from individual embryos. Green RM, Leach CL, Hoehn N, Marcucio RS, Hallgrímsson B The society for craniofacial genetics and developmental biology 39th annual meeting. Fish JL, Albertson C, Harris MP, Lozanoff S, Marcucio RS, Richtsmeier JT, Trainor PA Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses. Pavlicev M, Mitteroecker P, Gonzalez PM, Rolian C, Jamniczky H, Villena FP, Marcucio R, Spritz R, Hallgrimsson B Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach. Schmidt-Bleek K, Marcucio R, Duda G FGFR-associated craniosynostosis syndromes and gastrointestinal defects. Hibberd CE, Bowdin S, Arudchelvan Y, Forrest CR, Brakora KA, Marcucio RS, Gong SG Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel. Gonzalez PN, Pavlicev M, Mitteroecker P, Pardo-Manuel de Villena F, Spritz RA, Marcucio RS, Hallgrímsson B The society for craniofacial genetics and developmental biology 38th annual meeting. Taneyhill LA, Hoover-Fong J, Lozanoff S, Marcucio R, Richtsmeier JT, Trainor PA 60 Minutes of Tension: The Hour Long Research Talk. Ralph Marcucio Evolvability and the Diversification of the Craniofacial Skeleton in the Domesticated Pigeon ( Columba livia ). Marta Linde-Medina, John Fondon, Ralph Marcucio, Benedikt Hallgrímsson, Nathan M. Young Facial surface morphology predicts variation in internal skeletal shape. Young NM, Sherathiya K, Gutierrez L, Nguyen E, Bekmezian S, Huang JC, Hallgrímsson B, Lee JS, Marcucio RS Factors affecting craniofacial development in a mouse model of Crouzon Syndrome. Katherine Brakora, Christopher J Percival, Rebecca Green, Siew-Ging Gong, Benedikt Hallgrimsson, Ralph Marcucio Matrix Reloaded: Devitalized Cartilage as a Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis. Jaselle M Perry, Donna M Poscablo, Brandon T Gaston, Diane P Hu, Theodore Miclau, Karen L Christman, Ralph S Marcucio, Chelsea S Bahney Trans differentiation of Chondrocytes to Osteoblasts during Endochondral Ossification in the Healing Mandible. Sarah Anne Wong, Diane Hu, Theodore Miclau, Chelsea Bahney, Ralph Marcucio Transdifferentiation of Chondrocytes to Osteoblasts during Bone Fracture Healing. Ralph Marcucio, Diane Hu, Frank Yang, Chelsea Bahney, Theodore Miclau Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC Beyond cell proliferation in avian facial morphogenesis. Linde-Medina M, Hallgrímsson B, Marcucio R Stem Cell Therapies in Orthopaedic Trauma. Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T Tissue engineering strategies for promoting vascularized bone regeneration. Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C Morphometrics, 3D Imaging, and Craniofacial Development. Hallgrimsson B, Percival CJ, Green R, Young NM, Mio W, Marcucio R Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face. Marcucio R, Hallgrimsson B, Young NM Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross. Percival CJ, Liberton DK, Pardo-Manuel de Villena F, Spritz R, Marcucio R, Hallgrímsson B Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape. Xu Q, Jamniczky H, Hu D, Green RM, Marcucio RS, Hallgrimsson B, Mio W Signals from the brain induce variation in avian facial shape. Hu D, Young NM, Xu Q, Jamniczky H, Green RM, Mio W, Marcucio RS, Hallgrimsson B Divergence of craniofacial developmental trajectories among avian embryos. Smith FJ, Percival CJ, Young NM, Hu D, Schneider RA, Marcucio RS, Hallgrimsson B Role of muscle stem cells during skeletal regeneration. Abou-Khalil R, Yang F, Lieu S, Julien A, Perry J, Pereira C, Relaix F, Miclau T, Marcucio R, Colnot C Facial development and alterations in FGF signaling in a mouse model of Crouzon Syndrome. Katherine Brakora, Yolanda Ho, Alexis Lainoff, Jennifer Wong, Siew-Ging Gong, Benedikt Hallgrimsson, Ralph Marcucio Mechanisms of FGF-Mediated Morphogenesis. Ralph Marcucio The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S A comparative examination of odontogenic gene expression in both toothed and toothless amniotes. Lainoff AJ, Moustakas-Verho JE, Hu D, Kallonen A, Marcucio RS, Hlusko LJ The multifaceted role of the vasculature in endochondral fracture repair. Bahney CS, Hu DP, Miclau T, Marcucio RS A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Hu D, Young NM, Li X, Xu Y, Hallgrímsson B, Marcucio RS Content Experts. Richard Anderson, Parker B. Antin, Cammon Arrington, Spencer Beasley, Brian L. Black, Janice L.B. Byrne, Jon Clarke, Martyn Cobourne, Simon J. Conway, Andrew Copp, George P. Daston, Mark Davenport, Jamie Davies, Elaine Dzierzak, Darrell J.R. Evans, John F. Fallon, Richard H. Finnell, Adriana Gittenberger-deGroot, Robert G. Gourdie, Anne Grapin-Botton, Anne Greenough, Barbara F. Hales, Hiroshi Hamada, Christine Hartmann, Takayuki Inagaki, Robyn Jamieson, Chaya Kalcheim, Matthew Kelley, Thomas Knudsen, Catherine E. Krull, Ralph Marcucio, Antoon F. Moorman, Guillermo Olivier, David M. Ornitz, Maurizio Pacifici, Roger K. Patient, Alan O. Perantoni, Theodore Pysher, Maria A. Ros, Yukio Saijoh, Ramesh A. Shivdasani, Jane C. Sowden, Nancy A. Speck, Rajanarayanan Srinivasan, Michael R. Stark, David K. Stevenson, Xin Sun, Cheryll Tickle, Gijs van den Brink, Valerie Wallace, James M. Wells, Arno Wessels, Heather M. Young Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Billington CJ, Schmidt B, Marcucio RS, Hallgrimsson B, Gopalakrishnan R, Petryk A Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T Let's face it--complex traits are just not that simple. Hallgrimsson B, Mio W, Marcucio RS, Spritz R Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Petryk A, Graf D, Marcucio R Surface landmark quantification of embryonic mouse craniofacial morphogenesis. Percival CJ, Green R, Marcucio R, Hallgrímsson B Biological perspectives of delayed fracture healing. Hankenson KD, Zimmerman G, Marcucio R A comparative examination of odontogenic markers in both toothed and toothless amniotes (344.3). Alexis Lainoff, Jacqueline Moustakas, Aki Kallonen, Keijo Hämälainen, Kathleen Smith, Diane Hu, Ralph Marcucio, Leslea Hlusko Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6). Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6). Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1). Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio Embryonic bauplans and the developmental origins of facial diversity and constraint. Young NM, Hu D, Lainoff AJ, Smith FJ, Diaz R, Tucker AS, Trainor PA, Schneider RA, Hallgrímsson B, Marcucio RS Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy. Abou-Khalil R, Yang F, Mortreux M, Lieu S, Yu YY, Wurmser M, Pereira C, Relaix F, Miclau T, Marcucio RS, Colnot C 9 Cartilage grafts for bone repair and regeneration. C.S. Bahney, R.S. Marcucio Contributor contact details. K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. Ambrosio, K.K. Mallick, J. Winnett, A. Bansiddhi, D.C. Dunand, G.C. Wang, Z.F. Lu, H. Zreiqat, C.S. Bahney, R.S. Marcucio, J. Venkatesan, S.K. Kim, L. Grøndahl, C.S. Goonasekera, K.S. Jack, S.A. Clarke, P. Walsh Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice. Slade Shantz JA, Yu YY, Andres W, Miclau T, Marcucio R Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model. Demirkiran G, Dede O, Yalcin N, Akel I, Marcucio R, Acaroglu E Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis. Li X, Young NM, Tropp S, Hu D, Xu Y, Hallgrímsson B, Marcucio RS Beneficial effects of oxygen- and lactate-production in scaffold designs. Marcucio R, Hunt TK, Miclau T The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos. Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS Embryonic origins of novelty and constraint in the amniote upper jaw. Nathan Young, Diane Hu, Alexis Lainoff, Benedikt Hallgrímsson, Ralph Marcucio Disruption of thrombospondin-2 accelerates ischemic fracture healing. Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ The role of oxygen during fracture healing. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS MMP9 regulates the cellular response to inflammation after skeletal injury. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C The generation of variation and the developmental basis for evolutionary novelty. Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS Anti-inflammatory treatment increases angiogenesis during early fracture healing. Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects. Yan-yiu Yu, Chelsea Bahney, Diane Hu, Ralph S. Marcucio, Theodore Miclau, III Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T A Novel Gene Crispld2 may Contribute to Facial Dysmophology in a Chicken Model of Crouzon's Syndrome. Xin Li, Stephen Tropp, Nathan Young, Benedikt Hallgrimsson, Ralph Marcucio Modulation of Shh signaling by microRNAs. Yanhua Xu, Diane Hu, Rebecca Barbeau, Andrea Barczak, Ralph Marcucio Neural crest cells pattern the surface cephalic ectoderm during FEZ formation. Hu D, Marcucio RS The Phenogenomics of Craniofacial Shape. Benedikt Hallgrimsson, Heather A. Jamniczky, Neus Martínez-Abadías, Nathan M. Young, Ralph S. Marcucio Tissue Interactions that Regulate Facial Morphogenesis. Ralph Marcucio, Nathan Young, Diane Hu, Benedikt Hallgrimsson Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes. Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel. Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A Signaling by SHH rescues facial defects following blockade in the brain. Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS Vascular endothelial growth factor improves bone repair in a murine nonunion model. Ogilvie CM, Lu C, Marcucio R, Lee M, Thompson Z, Hu D, Helms JA, Miclau T Epigenetic integration of the developing brain and face. Trish E. Parsons, Eric J. Schmidt, Julia C. Boughner, Heather A. Jamniczky, Ralph S. Marcucio, Benedikt Hallgrímsson Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model. Dede O, Akel I, Demirkiran G, Yalcin N, Marcucio R, Acaroglu E Epigenetic integration of the developing brain and face. Parsons TE, Schmidt EJ, Boughner JC, Jamniczky HA, Marcucio RS, Hallgrímsson B Mechanical stability affects angiogenesis during early fracture healing. Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T Effects of Bone Morphogenetic Proteins on TGF-beta, Wnt and BMP Pathways During Tibial Fracture Repair. Yan Yiu Yu, Shirley Lieu, Theodore Miclau, Celine Colnot, Ralph Marcucio Identification and Validation of Gene Expression Profile in Facial Dysmorphology of Craniosynostosis Crouzon Syndrome. Xin Li, Stephen Tropp, Niousha Saghafi, Ralph Marcucio The cellular basis of hypoxia induced craniofacial malformations. Francis Joel Smith, Ralph S Marcucio, Diane Hu, Benedikt Hallgrimsson Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development. Diane Hu, Ralph S. Marcucio Assessing signaling properties of ectodermal epithelia during craniofacial development. Hu D, Marcucio RS Mechanisms that underlie co-variation of the brain and face. Marcucio RS, Young NM, Hu D, Hallgrimsson B Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape. Young NM, Chong HJ, Hu D, Hallgrímsson B, Marcucio RS Trauma-induced inflammation and fracture healing. Pape HC, Marcucio R, Humphrey C, Colnot C, Knobe M, Harvey EJ Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. Xing Z, Lu C, Hu D, Miclau T, Marcucio RS Action of IL-1beta during fracture healing. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment. Lu C, Xing Z, Yu YY, Colnot C, Miclau T, Marcucio RS A craniosynostosis-syndrome related Fgfr2 mutation promotes early craniofacial defects in chick. Xin Li, Stephen Tropp, Ralph Marcucio Multiple roles for CCR2 during fracture healing. Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS Absence of beta3 integrin accelerates early skeletal repair. Hu D, Lu C, Sapozhnikova A, Barnett M, Sparrey C, Miclau T, Marcucio RS Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic Covariation. Hallgrímsson B, Jamniczky H, Young NM, Rolian C, Parsons TE, Boughner JC, Marcucio RS Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. Yu YY, Lieu S, Lu C, Miclau T, Marcucio RS, Colnot C Basic research in orthopedic surgery: Current trends and future directions. Lu C, Buckley JM, Colnot C, Marcucio R, Miclau T Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent idiopathic scoliosis. Acaroglu E, Akel I, Alanay A, Yazici M, Marcucio R Hypoxia as an Environmental Cause of Holoprosencephaly. Francis Joel Smith, Ralph S Marcucio Rescuing craniofacial development in an avian model of holoprosencephaly. H. Jonathan Chong, Ralph Marcucio The effect of early Bone Morphogenetic Protein (BMP) activation on craniofacial development. H. Jonathan Chong, Ralph Marcucio The relationship between variable SHH signaling and the severity of structural defects in the face and brain. Nathan M. Young, Diane Hu, H. Jonathan Chong, Benedikt Hallgrímsson, Wei Liu, Ralph Marcucio The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. Akel I, Kocak O, Bozkurt G, Alanay A, Marcucio R, Acaroglu E The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model. Akel I, Demirkiran G, Alanay A, Karahan S, Marcucio R, Acaroglu E Effect of bone morphogenetic protein signaling on development of the jaw skeleton. Hu D, Colnot C, Marcucio RS A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm. Hu D, Marcucio RS Unique organization of the frontonasal ectodermal zone in birds and mammals. Hu D, Marcucio RS Effect of age on vascularization during fracture repair. Lu C, Hansen E, Sapozhnikova A, Hu D, Miclau T, Marcucio RS Epithelial-Mesenchymal Interactions during Facial Development in Mice. Ralph Marcucio, Diane Hu Tibial fracture decreases oxygen levels at the site of injury. Lu C, Rollins M, Hou H, Swartz HM, Hopf H, Miclau T, Marcucio RS Effects of delayed stabilization on fracture healing. Miclau T, Lu C, Thompson Z, Choi P, Puttlitz C, Marcucio R, Helms JA Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development. Foppiano S, Hu D, Marcucio RS Bone morphogenetic proteins (BMPs) direct formation of a signaling center that regulates facial development. Ralph S. Marcucio, Silvia Foppiano, Diane Hu Ischemia leads to delayed union during fracture healing: a mouse model. Lu C, Miclau T, Hu D, Marcucio RS Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ Assessing angiogenesis during fracture healing. Lu C, Marcucio R, Miclau T Cellular basis for age-related changes in fracture repair. C LU, T MICLAU, D HU, E HANSEN, K TSUI, C PUTTLITZ, R MARCUCIO Molecular interactions coordinating the development of the forebrain and face. Marcucio RS, Cordero DR, Hu D, Helms JA Cellular basis for age-related changes in fracture repair. Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS The Collaborative Cross, a community resource for the genetic analysis of complex traits. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F, Complex Trait Consortium Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. Cordero D, Marcucio R, Hu D, Gaffield W, Tapadia M, Helms JA Morphogenesis of blood vessels in the head muscles of avian embryo: spatial, temporal, and VEGF expression analyses. Ruberte J, Carretero A, Navarro M, Marcucio RS, Noden D A zone of frontonasal ectoderm regulates patterning and growth in the face. Hu D, Marcucio RS, Helms JA Prenatal morphogenesis of the human mental foramen. Radlanski RJ, Renz H, Müller U, Schneider RS, Marcucio RS, Helms JA Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis. Noden DM, Marcucio R, Borycki AG, Emerson CP Myotube heterogeneity in developing chick craniofacial skeletal muscles. Marcucio RS, Noden DM In vitro interaction between oviduct epithelial and equine sperm. Ellington JE, Ignotz GG, Varner DD, Marcucio RS, Mathison P, Ball BA
