Biography I am a chemical biologist with a strong background in leveraging organic chemical tools and strategies to drive small-molecule drug discovery and expand therapeutic possibilities. My research centers on using chemical groups such as tetrazole, isoxazole, and trioxolane to develop small-molecule probes for high-throughput screening of novel drug candidates and direct profiling of cellular druggable targets through chemoproteomics. I also have extensive experience in designing activatable chemical probes, drug conjugates, fluorescent probes, prodrugs, and radioligand agents for targeted cancer treatment. Additionally, I also have extensive experience in applying small-molecule probes and inorganic nanomaterials to engineer nanomedicines for precise oncology. Role Postdoc Category Research Education PhD, 2021 - Chemical Biology, City University of Hong Kong Publications MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model. Liu P, Long K, Wang Y, Sulaiman JE, Wang B, Zhou X, Liu C, Cheng Y, Cai Y, Li H, Xu A, Cheng KK Metabolism: clinical and experimental . Aug 7, 2026 Lipodystrophy induces gut microbiota dysbiosis and its related glucose dysmetabolism in mice. Long K, Liu Z, Liu P, Zhang W, Gao M, Gan G, Cao X, Cheng Y, Wang B, Yuan X, Wang B, Zhao D, Xu A, Sulaiman JE, Cheng KK NPJ biofilms and microbiomes . Jul 18, 2026 Application of age- and sex-specific reference intervals for thyroid-stimulating hormone and free thyroxine in evaluating incidence and trends of thyroid dysfunctions: A population-based cohort study. Lu J, Tang CM, Ge GM, Cheng KK, Lee KC, Tan KC, Lam SK, Cheung EY, Cheung CL, Li GH BMC medicine . May 20, 2026 How muscle talks to brain: apelin protein mediates exercise-induced antidepressant effects. Yu J, Cheng T, Guo H, Song Z, Zhong Y, Lee TH, Li J, Formolo DA, Hussain A, Le K, Yao Y, Abel RL, Cheung WH, Lin K, Xu A, Cheng KK, Yau SY Molecular psychiatry . May 14, 2026 Investigating the replicability of the social and behavioural sciences. Tyner AH, Abatayo AL, Daley M, Field S, Fox N, Haber NA, Hahn KM, Struhl MK, Mawhinney B, Miske O, Silverstein P, Soderberg CK, Stankov T, Abbasi A, Aberson CL, Aczel B, Adamkovic M, Albayrak N, Allen PJ, Andreychik M, Awtrey E, Axxe E, Azevedo F, Bader MD, Bago B, Bailey J, Bakker M, Banik G, Banks GC, Baskin E, Batruch A, Beatteay A, Behr SM, Berente N, Berry Z, Bialkowski J, Bodroža B, Boeschoten L, Bognar M, Bokhove C, Bonfiglio D, Bouwman R, Brady TF, Braithwaite SR, Briceño Jiménez G, Brick C, Bricka T, Briker R, Brown AN, Brown GDA, van Aert RCM, Caldwell K, Capitan S, Capitán T, Chandler J, Charles T, Chartier CR, Chawdhary R, Cheng KJ, Chopik WJ, Clark B, Colvin VE, Comer CC, Costantini G, Coupé T, Cummins J, Czernatowicz-Kukuczka A, de Leeuw J, Dobolyi D, Druckman JN, Duan J, Dujmovic M, Dunleavy DJ, Durkee PK, Emery C, Esterling KM, Evans TR, Fedor A, Fernández-Castilla B, Fiala N, Field JG, Fong N, Fonseca MA, Freeman ALJ, Freese J, Geiger SJ, Geng J, Getz LM, Geven LM, Gleibs IH, Gonzales DP, Gooty J, Gourdon-Kanhukamwe A, Greculescu C, Griffin SM, Grigoryan L, Grunow M, Gunby N, Hall B, Hanel PHP, Hannon EE, Harper S, Held MJ, Hickman L, Higgins NC, Hippel S, Hoeppner S, Hong S, Hostler TJ, Inzlicht M, Izydorczak K, Jaeger B, Jankowsky K, Jarke-Neuert J, Jensen M, Jokic B, Jolles D, Jolly P, Jones AM, Juanchich M, Kacmár P, Kapoor H, Keljanovic A, Koirala S, Kolczynska M, Kouroupaki D, Kühnen U, Landgrave M, Larson MJ, Laulié L, Lawrence ACE, Le Forestier JM, Leahy KE, Lee S, Leslie J, Lewis SC, Limnios C, Lin H, Liu AC, Lloyd JW, Ludvig EA, Lynott D, MacDonald J, Mallik P, Mallinson DJ, Marinazzo D, Martarelli CS, Matacotta J, McBride A, McHugh C, McMillan G, Méndez E, Metzger M, Michaelides MP, Michalak J, Micheli L, Miller JK, Milyavskaya M, Molden DC, Monjaras AG, Moreau D, Morrow A, Moya C, Mudrik L, Mulder LB, Munt KA, Nandi A, Nason K, Nast C, Nave G, Nax HH, Neubauer F, Nguyen PLL, Nichols AL, Nilsonne G, O'Boyle E, Oettinghaus J, Oh J, Oshana A, Ostermann T, Ostrowski RP, Oyebanjo A, Panczak R, Patrianakos J, Pavez I, Pavlov YG, Persson S, Perugini M, Peters K, Pieters C, Ponizovskiy V, Porter ND, Prenoveau JM, Puric D, Purol MF, Puthillam A, Quinn KA, Ramljak M, Reed WR, Ritchie M, Ritzau M, Roche SP, Rodela R, Röer JP, Ropovik I, Rothschild J, Saal J, Safadi H, Samaha J, Sanchez M, Sankaran S, Santos D, Sargent AC, Sauter M, Schmidt K, Schnabel L, Schroeder AN, Schuetz SW, Schuetze BA, Schulte-Mecklenbeck M, Schütz A, Sevigny EL, Shackleton E, Shafranek RM, Shaki S, Shakya S, Sirota M, Sisco MR, Sitnikov MM, Slevc LR, Smalarz L, Smith CT, Snyder JS, Sommet N, Sonmez F, Spellman BA, Stanulewicz-Buckley N, Stock G, Street CNH, Strømland E, Sundelin T, Syed M, Szabelska A, Szaszi B, Szumowska E, Tagat A, Täuber S, Tay L, Thapa S, Thatcher J, Tsaklakidou D, Tummers L, Turkovich E, Tutor MV, Urbanska K, van 't Veer AE, van Assen M, van de Ven N, van den Goorbergh R, Vargo EJ, Vaughn LA, Vazire S, Vermeulen JM, Vo DTH, Volkman V, Wagenmakers EJ, Wagner D, Walasek L, Walter F, Warmelink L, Wei L, Weißflog MI, Weller N, Wichman AL, Wilbiks J, Williams JR, Wolfe K, Wort F, Wright R, Wulff JN, Xue X, Yan VX, Yang Y, Yoon S, Žeželj I, Zhang Y, Ziano I, Zogmaister C, Zupan Z, Zwaan RA, Nosek BA, Errington TM Nature . Apr 1, 2026 Investigating the reproducibility of the social and behavioural sciences. Miske O, Abatayo AL, Daley M, Dirzo M, Fox N, Haber N, Hahn KM, Struhl MK, Mawhinney B, Silverstein P, Stankov T, Tyner AH, Adamkovic M, Alzahawi S, Anafinova S, Awtrey E, Axxe E, Bailey J, Bakker BN, Balaji A, Banik G, Bartoš F, Berkman H, Berry Z, Bethke FS, Brady TF, Breznau N, Capitan S, Capitán T, Caquelin L, Cheng KJ, Chopik WJ, Clochard GJ, Coupé T, Cummins J, Burak EGD, Duan J, Esterling KM, Evans TR, Fiala N, Field J, Gay V, Geng J, Gereke J, Gleibs IH, Gourdon-Kanhukamwe A, Grigoryev D, Gunby N, Hanel PHP, Hong S, Houlihan SD, Huntington-Klein N, Izydorczak K, Jankowsky K, Jonas K, Kacmár P, Kapoor H, Karcher S, Kolczynska M, Kretschmer D, Lazarevic L, Leahy KE, Lee JC, Limnios C, Liu AC, Lloyd JW, Lopez-Nicolas R, Lou NM, Lucas RE, Maier M, Mallinson DJ, Martoncik M, McCall MC, Mehta N, Méndez E, Michalak J, Molden DC, Mushtaq F, Neuendorf C, Nichols AL, Nilsonne G, O'Boyle E, Oh J, Ostermann T, Oyebanjo A, Panczak R, Pavlov YG, Pavlovic Z, Peter N, Peters K, Porter ND, Purol M, Puthillam A, Ramljak M, Reader AT, Reed WR, Röer JP, Ropovik I, Savi AO, Schmidt K, Schnabel L, Sevigny EL, Shaki S, Shakya S, Soh A, Somo A, Sonmez F, Strømland E, Suchow JW, Szabelska A, Tagat A, Tutor MV, Urbanska K, Van Dessel P, Vargo EJ, Vo DTH, Volkman V, Wang K, Wichman AL, Williams JR, Winter F, Wintermantel F, Zhang N, Ziano I, Zogmaister C, Zupan Z, Nosek BA, Errington TM Nature . Apr 1, 2026 Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis. Lin H, Ho MYM, Wang B, Mansoori S, Yang Y, Wang W, So PK, Xu A, Yang S, Chang J, Man AMH, Piao H, Gao C, Siu PMF, Li X, Cheng KKY Nature communications . Mar 2, 2026 Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease. Gan G, Chen R, Zheng P, Long K, Cheng KKY, Sulaiman JE, Huang X Frontiers in cellular and infection microbiology . Feb 27, 2026 Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. Zhou X, Lu J, Wang Z, Cheng KK, Li GH Diabetes, obesity & metabolism . Feb 18, 2026 Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity. Wang Y, Wu J, Yao J, Chen J, Cheng KKY, Ho MY, Lee CH, Lam KS, Tse MA, Panagiotou G, Xu A Cell metabolism . Nov 18, 2025 Subcutaneous white adipose tissue-derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice. Long K, Liu P, Wang Y, Sulaiman JE, Hoque M, Li GHY, Zhao DD, Lee PK, Siu GK, Lee AW, Liu Z, So PK, Cai Y, Woo CW, Chan CB, Xu A, Cheng KK The Journal of clinical investigation . Nov 17, 2025 Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources. Sulaiman JE, Zhan Y, Wang S, Lai KL, Li JHW, Yutong DY, Tsim KWK, Cheng KKY, Lai Y, Lam H Frontiers in microbiology . Nov 6, 2025 Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex. Cheng T, Douglas Affonso F, Yu J, Zhong Y, Ma Z, Hussain A, Natalia Paludo Silveira F, Zhang L, Cheng KK, Kranz GS, Lin K, Chen G, Siu PM, Yoo JS, Lai CSW, Xu A, So KF, Yau SY Molecular psychiatry . Oct 25, 2025 Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing. Ganapathy T, Yuan J, Ho MY, Wu KK, Hoque MM, Wang B, Li X, Wang K, Wabitsch M, Feng X, Niu Y, Long K, Lian Q, Zhu Y, Cheng KK Nature communications . Oct 6, 2025 Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway. Wang B, Wang Z, Yang Y, Ho MYM, Yang R, Yang H, Liu S, Lin H, Cheng KKY, Li X Journal of diabetes . Jun 1, 2025 Predicting the replicability of social and behavioural science claims in COVID-19 preprints. Marcoci A, Wilkinson DP, Vercammen A, Wintle BC, Abatayo AL, Baskin E, Berkman H, Buchanan EM, Capitán S, Capitán T, Chan G, Cheng KJG, Coupé T, Dryhurst S, Duan J, Edlund JE, Errington TM, Fedor A, Fidler F, Field JG, Fox N, Fraser H, Freeman ALJ, Hanea A, Holzmeister F, Hong S, Huggins R, Huntington-Klein N, Johannesson M, Jones AM, Kapoor H, Kerr J, Kline Struhl M, Kolczynska M, Liu Y, Loomas Z, Luis B, Méndez E, Miske O, Mody F, Nast C, Nosek BA, Simon Parsons E, Pfeiffer T, Reed WR, Roozenbeek J, Schlyfestone AR, Schneider CR, Soh A, Song Z, Tagat A, Tutor M, Tyner AH, Urbanska K, van der Linden S Nature human behaviour . Dec 20, 2024 Branched-chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases. Mansoori S, Ho MY, Ng KK, Cheng KK Obesity reviews : an official journal of the International Association for the Study of Obesity . Oct 25, 2024 The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation. Yang Y, Wang B, Dong H, Lin H, Yuen-Man Ho M, Hu K, Zhang N, Ma J, Xie R, Cheng KK, Li X Proceedings of the National Academy of Sciences of the United States of America . Oct 22, 2024 From exosomes to mitochondria and myocardial infarction: Molecular insight and therapeutic challenge. Liu C, Zhang D, Long K, Qi W, Pang L, Li J, Cheng KK, Cai Y Pharmacological research . Oct 18, 2024 MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice. Wu KK, Xu X, Wu M, Li X, Hoque M, Li GHY, Lian Q, Long K, Zhou T, Piao H, Xu A, Hui HX, Cheng KK Nature communications . Oct 4, 2024 Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains. Klope MT, Tapia Cardona JA, Chen J, Gonciarz RL, Cheng K, Jaishankar P, Kim J, Legac J, Rosenthal PJ, Renslo AR ACS medicinal chemistry letters . Sep 5, 2024 Reactivity-Tunable Fluorescent Platform for Selective and Biocompatible Modification of Cysteine or Lysine. Ren X, Li H, Peng H, Yang Y, Su H, Huang C, Wang X, Zhang J, Liu Z, Wei W, Cheng K, Zhu T, Lu Z, Li Z, Zhao Q, Tang BZ, Yao SQ, Song X, Sun H Advanced science (Weinheim, Baden-Wurttemberg, Germany) . Jun 19, 2024 The interplay between the muscle and liver in the regulation of glucolipid metabolism. Chen C, Xie L, Zhang M, Cheng KKY, Jia W Journal of molecular cell biology . Apr 10, 2024 TransPTM: a transformer-based model for non-histone acetylation site prediction. Meng L, Chen X, Cheng K, Chen N, Zheng Z, Wang F, Sun H, Wong KC Briefings in bioinformatics . Mar 27, 2024 Identification of SIRT3 as an eraser of H4K16la. Fan Z, Liu Z, Zhang N, Wei W, Cheng K, Sun H, Hao Q iScience . Aug 28, 2023 An End-to-End Dynamic Posture Perception Method for Soft Actuators Based on Distributed Thin Flexible Porous Piezoresistive Sensors. Shu J, Wang J, Cheng KC, Yeung LF, Li Z, Tong RK Sensors (Basel, Switzerland) . Jul 6, 2023 Editorial: Metabolic associated fatty liver disease: clinical perspectives from pathogenesis to diagnosis and treatment. Huang Z, Ye D, Loomes K, Cheng KK, Hui HX Frontiers in endocrinology . Jun 30, 2023 Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice. Cheong LY, Wang B, Wang Q, Jin L, Kwok KHM, Wu X, Shu L, Lin H, Chung SK, Cheng KKY, Hoo RLC, Xu A Nature communications . Mar 3, 2023 De Novo Designed Self-Assembling Rhodamine Probe for Real-Time, Long-Term and Quantitative Live-Cell Nanoscopy. Zhang J, Shi H, Huang C, Mei L, Guo Q, Cheng K, Wu P, Su D, Chen Q, Gan S, Wing Chan CK, Shi J, Chen JL, Jonathan Choi CH, Yao SQ, Chen XK, Tang BZ, He J, Sun H ACS nano . Feb 6, 2023 Safety and antitumor activity of GD2-Specific 4SCAR-T cells in patients with glioblastoma. Liu Z, Zhou J, Yang X, Liu Y, Zou C, Lv W, Chen C, Cheng KK, Chen T, Chang LJ, Wu D, Mao J Molecular cancer . Jan 9, 2023 Universal Strategy to Develop Fluorogenic Probes for Lysine Deacylase/Demethylase Activity and Application in Discriminating Demethylation States. Wei W, Zhang J, Xu Z, Liu Z, Huang C, Cheng K, Meng L, Matsuda Y, Hao Q, Zhang H, Sun H ACS sensors . Jan 5, 2023 Self-assembled nano-photosensitizer for targeted, activatable, and biosafe cancer phototheranostics. Cheng K, Qi J, Zhang J, Li H, Ren X, Wei W, Meng L, Li J, Li Q, Zhang H, Deng W, Sun H, Mei L Biomaterials . Nov 15, 2022 Developing Isoxazole as a Native Photo-Cross-Linker for Photoaffinity Labeling and Chemoproteomics. Cheng K, Qi J, Ren X, Zhang J, Li H, Xiao H, Wang R, Liu Z, Meng L, Ma N, Sun H Angewandte Chemie (International ed. in English) . Oct 19, 2022 Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice. Shiu HT, Pan X, Liu Q, Long K, Cheng KKY, Ko BC, Fang JK, Zhu Y Journal of hazardous materials . Jul 28, 2022 Mini-review: Recent advances in post-translational modification site prediction based on deep learning. Meng L, Chan WS, Huang L, Liu L, Chen X, Zhang W, Wang F, Cheng K, Sun H, Wong KC Computational and structural biotechnology journal . Jun 30, 2022 Robust Artificial Interphases Constructed by a Versatile Protein-Based Binder for High-Voltage Na-Ion Battery Cathodes. Li H, Guan C, Zhang J, Cheng K, Chen Q, He L, Ge X, Lai Y, Sun H, Zhang Z Advanced materials (Deerfield Beach, Fla.) . Jun 9, 2022 Estimating the EQ-5D-5L value set for the Philippines. Miguel RTD, Rivera AS, Cheng KJG, Rand K, Purba FD, Luo N, Zarsuelo MA, Genuino-Marfori AJ, Florentino-Fariñas I, Guerrero AM, Lam HY Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation . May 9, 2022 YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells. Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO Diabetes . May 1, 2022 Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. Ahuja P, Bi X, Ng CF, Tse MCL, Hang M, Pang BPS, Iu ECY, Chan WS, Ooi XC, Sun A, Herlea-Pana O, Liu Z, Yang X, Jiao B, Ma X, Wu KKL, Lee LTO, Cheng KKY, Lee CW, Chan CB Hepatology (Baltimore, Md.) . Apr 22, 2022 A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy. Wu KKL, Cheng KKY Autophagy . Feb 23, 2022 PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome. Yang R, Hu Y, Lee CH, Liu Y, Diaz-Canestro C, Fong CHY, Lin H, Cheng KKY, Pravelil AP, Song E, Lam KSL, Xu A European journal of endocrinology . Dec 10, 2021 The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages. Wu KKL, Long K, Lin H, Siu PMF, Hoo RLC, Ye D, Xu A, Cheng KKY Nature communications . Nov 17, 2021 Adipose MDM2 regulates systemic insulin sensitivity. Hallenborg P, Jensen BAH, Fjære E, Petersen RK, Belmaâti MS, Rasmussen SS, Gunnarsson JP, Lauritzen P, Cheng KKY, Hermansson M, Sonne SB, Ejsing CS, Xu A, Kratchmarova I, Krüger M, Madsen L, Kristiansen K, Blagoev B Scientific reports . Nov 8, 2021 Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM Advanced science (Weinheim, Baden-Wurttemberg, Germany) . Jun 27, 2021 Sarcopenia and mortality in cancer: A meta-analysis. Au PC, Li HL, Lee GK, Li GH, Chan M, Cheung BM, Wong IC, Lee VH, Mok J, Yip BH, Cheng KK, Wu CH, Cheung CL Osteoporosis and sarcopenia . Mar 30, 2021 Different definition of sarcopenia and mortality in cancer: A meta-analysis. Li HL, Au PC, Lee GK, Li GH, Chan M, Cheung BM, Wong IC, Lee VH, Mok J, Yip BH, Cheng KK, Wu CH, Cheung CL Osteoporosis and sarcopenia . Mar 19, 2021 The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis. Li GH, Lee GK, Au PC, Chan M, Li HL, Cheung BM, Wong IC, Lee VH, Mok J, Yip BH, Cheng KK, Wu CH, Cheung CL Osteoporosis and sarcopenia . Mar 12, 2021 Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling. Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, Wang S, Xu A, Xia Z Theranostics . Mar 4, 2021 miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities. Yang X, Liu J, Wang C, Cheng KK, Xu H, Li Q, Hua T, Jiang X, Sheng L, Mao J, Liu Z Oncogenesis . Feb 12, 2021 Systematic review and meta-analysis of lean mass and mortality: Rationale and study description. Cheung CL, Lee GK, Au PC, Li GH, Chan M, Li HL, Cheung BM, Wong IC, Lee VH, Mok J, Yip BH, Cheng KK, Wu CH Osteoporosis and sarcopenia . Feb 11, 2021 The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells. Wang B, Lin H, Li X, Lu W, Kim JB, Xu A, Cheng KKY Proceedings of the National Academy of Sciences of the United States of America . Oct 29, 2020 Heterobifunctional PEG-grafted black phosphorus quantum dots: "Three-in-One" nano-platforms for mitochondria-targeted photothermal cancer therapy. Qi J, Xiong Y, Cheng K, Huang Q, Cao J, He F, Mei L, Liu G, Deng W Asian journal of pharmaceutical sciences . Oct 18, 2020 A pyrene-based ratiometric fluorescent probe with a large Stokes shift for selective detection of hydrogen peroxide in living cells. Chen Q, Cheng K, Wang W, Yang L, Xie Y, Feng L, Zhang J, Zhang H, Sun H Journal of pharmaceutical analysis . Aug 4, 2020 Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice. Wang P, Liang Y, Chen K, Yau SY, Sun X, Cheng KK, Xu A, So KF, Li A Frontiers in cellular neuroscience . Jul 3, 2020 Influenza-associated excess mortality in the Philippines, 2006-2015. Cheng KJG, Rivera AS, Lam HY, Ulitin AR, Nealon J, Dizon R, Wu DB PloS one . Jun 17, 2020 Controllable Cleavage of C-N Bond-Based Fluorescent and Photoacoustic Dual-Modal Probes for the Detection of H2S in Living Mice. Zhang J, Wen G, Wang W, Cheng K, Guo Q, Tian S, Liu C, Hu H, Zhang Y, Zhang H, Wang L, Sun H ACS applied bio materials . Jun 11, 2020 APPL2 Negatively Regulates Olfactory Functions by Switching Fate Commitments of Neural Stem Cells in Adult Olfactory Bulb via Interaction with Notch1 Signaling. Gao C, Yan T, Chen X, Cheng KKY, Xu A, Shen J Neuroscience bulletin . May 28, 2020 Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. Liu Z, Ge R, Zhou J, Yang X, Cheng KK, Tao J, Wu D, Mao J Oncogenesis . Apr 14, 2020 Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome. Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM Scientific reports . Mar 26, 2020 The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders. Liu Z, Wu KKL, Jiang X, Xu A, Cheng KKY Clinical science (London, England : 1979) . Jan 31, 2020 Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors. Ma N, Zhang ZM, Lee JS, Cheng K, Lin L, Zhang DM, Hao P, Ding K, Ye WC, Li Z ACS chemical biology . Nov 26, 2019 The Novel Perspectives of Adipokines on Brain Health. Lee TH, Cheng KK, Hoo RL, Siu PM, Yau SY International journal of molecular sciences . Nov 11, 2019 An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells. Duan Q, Zheng G, Li Z, Cheng K, Zhang J, Yang L, Jiang Y, Zhang H, He J, Sun H Journal of materials chemistry. B . Jul 31, 2019 Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis. Ma Y, Zhang M, Yu H, Lu J, Cheng KKY, Zhou J, Chen H, Jia W Metabolism: clinical and experimental . Jul 2, 2019 Self-Administered Auricular Acupressure Integrated With a Smartphone App for Weight Reduction: Randomized Feasibility Trial. Suen L, Wang W, Cheng KKY, Chua MCH, Yeung JWF, Koh WK, Yeung SKW, Ho JYS JMIR mHealth and uHealth . May 29, 2019 Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance. Wang B, Cheng KK International journal of molecular sciences . Nov 11, 2018 The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. Liu Z, Jin L, Yang JK, Wang B, Wu KKL, Hallenborg P, Xu A, Cheng KKY Diabetes . Aug 21, 2018 Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults. Supriya R, Tam BT, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LW, Yung BY, Sheridan S, Siu PM PloS one . Aug 16, 2018 Adipokine Profiling in Adult Women With Central Obesity and Hypertension. Supriya R, Yung BY, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LWC, Sheridan S, Siu PM Frontiers in physiology . Mar 27, 2018 Yoga training modulates adipokines in adults with high-normal blood pressure and metabolic syndrome. Supriya R, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LW, Yung BY, Siu PM Scandinavian journal of medicine & science in sports . Feb 7, 2018 Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Guo VY, Cao B, Cai C, Cheng KK, Cheung BMY Acta diabetologica . Nov 11, 2017 Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker. Cheng K, Lee JS, Hao P, Yao SQ, Ding K, Li Z Angewandte Chemie (International ed. in English) . Oct 23, 2017 Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy. Hoo RL, Shu L, Cheng KK, Wu X, Liao B, Wu D, Zhou Z, Xu A Scientific reports . Jan 17, 2017 APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes. Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK Diabetologia . Dec 23, 2016 Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, Xu A, Lam KS, Chan KH Molecular neurodegeneration . Nov 25, 2016 Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice. Kwok KHM, Cheng KKY, Hoo RLC, Ye D, Xu A, Lam KSL Clinical science (London, England : 1979) . Aug 10, 2016 SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Jang H, Lee GY, Selby CP, Lee G, Jeon YG, Lee JH, Cheng KK, Titchenell P, Birnbaum MJ, Xu A, Sancar A, Kim JB Nature communications . Jul 14, 2016 The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells. Li X, Cheng KKY, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RLC, Lam KSL, Ikeda Y, Gao X, Xu A Nature communications . Jun 6, 2016 NUCKS is a positive transcriptional regulator of insulin signaling. Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akincilar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W, Tergaonkar V Cell reports . Jun 12, 2014 The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Cheng KK, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KS, Xu A Diabetes . May 30, 2014 TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A The Biochemical journal . Oct 15, 2013 PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KK, Xu A, Lee KM, Jiang L, Xia J PLoS biology . Apr 23, 2013 Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A PloS one . Dec 27, 2012
