Ke Cheng, PhD

Postdoctoral Scholar

[email protected]

View Full UCSF Profile

Biography

I am a chemical biologist with a strong background in leveraging organic chemical tools and strategies to drive small-molecule drug discovery and expand therapeutic possibilities. My research centers on using chemical groups such as tetrazole, isoxazole, and trioxolane to develop small-molecule probes for high-throughput screening of novel drug candidates and direct profiling of cellular druggable targets through chemoproteomics. I also have extensive experience in designing activatable chemical probes, drug conjugates, fluorescent probes, prodrugs, and radioligand agents for targeted cancer treatment. Additionally, I also have extensive experience in applying small-molecule probes and inorganic nanomaterials to engineer nanomedicines for precise oncology.

Role

Postdoc

Category

Research

Education

PhD, 2021 - Chemical Biology, City University of Hong Kong

Publications

From exosomes to mitochondria and myocardial infarction: Molecular insight and therapeutic challenge.

Liu C, Zhang D, Long K, Qi W, Pang L, Li J, Cheng KK, Cai Y

Pharmacological research

MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice.

Wu KK, Xu X, Wu M, Li X, Hoque M, Li GHY, Lian Q, Long K, Zhou T, Piao H, Xu A, Hui HX, Cheng KK

Nature communications

Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains.

Klope MT, Tapia Cardona JA, Chen J, Gonciarz RL, Cheng K, Jaishankar P, Kim J, Legac J, Rosenthal PJ, Renslo AR

ACS medicinal chemistry letters

Reactivity-Tunable Fluorescent Platform for Selective and Biocompatible Modification of Cysteine or Lysine.

Ren X, Li H, Peng H, Yang Y, Su H, Huang C, Wang X, Zhang J, Liu Z, Wei W, Cheng K, Zhu T, Lu Z, Li Z, Zhao Q, Tang BZ, Yao SQ, Song X, Sun H

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

TransPTM: a transformer-based model for non-histone acetylation site prediction.

Meng L, Chen X, Cheng K, Chen N, Zheng Z, Wang F, Sun H, Wong KC

Briefings in bioinformatics

Identification of SIRT3 as an eraser of H4K16la.

Fan Z, Liu Z, Zhang N, Wei W, Cheng K, Sun H, Hao Q

An End-to-End Dynamic Posture Perception Method for Soft Actuators Based on Distributed Thin Flexible Porous Piezoresistive Sensors.

Shu J, Wang J, Cheng KC, Yeung LF, Li Z, Tong RK

Sensors (Basel, Switzerland)

De Novo Designed Self-Assembling Rhodamine Probe for Real-Time, Long-Term and Quantitative Live-Cell Nanoscopy.

Zhang J, Shi H, Huang C, Mei L, Guo Q, Cheng K, Wu P, Su D, Chen Q, Gan S, Wing Chan CK, Shi J, Chen JL, Jonathan Choi CH, Yao SQ, Chen XK, Tang BZ, He J, Sun H

Universal Strategy to Develop Fluorogenic Probes for Lysine Deacylase/Demethylase Activity and Application in Discriminating Demethylation States.

Wei W, Zhang J, Xu Z, Liu Z, Huang C, Cheng K, Meng L, Matsuda Y, Hao Q, Zhang H, Sun H

Self-assembled nano-photosensitizer for targeted, activatable, and biosafe cancer phototheranostics.

Cheng K, Qi J, Zhang J, Li H, Ren X, Wei W, Meng L, Li J, Li Q, Zhang H, Deng W, Sun H, Mei L

Developing Isoxazole as a Native Photo-Cross-Linker for Photoaffinity Labeling and Chemoproteomics.

Cheng K, Qi J, Ren X, Zhang J, Li H, Xiao H, Wang R, Liu Z, Meng L, Ma N, Sun H

Angewandte Chemie (International ed. in English)

Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice.

Shiu HT, Pan X, Liu Q, Long K, Cheng KKY, Ko BC, Fang JK, Zhu Y

Journal of hazardous materials

Mini-review: Recent advances in post-translational modification site prediction based on deep learning.

Meng L, Chan WS, Huang L, Liu L, Chen X, Zhang W, Wang F, Cheng K, Sun H, Wong KC

Computational and structural biotechnology journal

Robust Artificial Interphases Constructed by a Versatile Protein-Based Binder for High-Voltage Na-Ion Battery Cathodes.

Li H, Guan C, Zhang J, Cheng K, Chen Q, He L, Ge X, Lai Y, Sun H, Zhang Z

Advanced materials (Deerfield Beach, Fla.)

YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells.

Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO

Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.

Ahuja P, Bi X, Ng CF, Tse MCL, Hang M, Pang BPS, Iu ECY, Chan WS, Ooi XC, Sun A, Herlea-Pana O, Liu Z, Yang X, Jiao B, Ma X, Wu KKL, Lee LTO, Cheng KKY, Lee CW, Chan CB

Hepatology (Baltimore, Md.)

A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy.

Wu KKL, Cheng KKY

The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.

Wu KKL, Long K, Lin H, Siu PMF, Hoo RLC, Ye D, Xu A, Cheng KKY

Nature communications

Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes.

Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling.

Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, Wang S, Xu A, Xia Z

Heterobifunctional PEG-grafted black phosphorus quantum dots: "Three-in-One" nano-platforms for mitochondria-targeted photothermal cancer therapy.

Qi J, Xiong Y, Cheng K, Huang Q, Cao J, He F, Mei L, Liu G, Deng W

Asian journal of pharmaceutical sciences

A pyrene-based ratiometric fluorescent probe with a large Stokes shift for selective detection of hydrogen peroxide in living cells.

Chen Q, Cheng K, Wang W, Yang L, Xie Y, Feng L, Zhang J, Zhang H, Sun H

Journal of pharmaceutical analysis

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice.

Wang P, Liang Y, Chen K, Yau SY, Sun X, Cheng KK, Xu A, So KF, Li A

Frontiers in cellular neuroscience

Controllable Cleavage of C-N Bond-Based Fluorescent and Photoacoustic Dual-Modal Probes for the Detection of H2S in Living Mice.

Zhang J, Wen G, Wang W, Cheng K, Guo Q, Tian S, Liu C, Hu H, Zhang Y, Zhang H, Wang L, Sun H

ACS applied bio materials

Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors.

Ma N, Zhang ZM, Lee JS, Cheng K, Lin L, Zhang DM, Hao P, Ding K, Ye WC, Li Z

ACS chemical biology

An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells.

Duan Q, Zheng G, Li Z, Cheng K, Zhang J, Yang L, Jiang Y, Zhang H, He J, Sun H

Journal of materials chemistry. B

Yoga training modulates adipokines in adults with high-normal blood pressure and metabolic syndrome.

Supriya R, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LW, Yung BY, Siu PM

Scandinavian journal of medicine & science in sports

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.

Cheng K, Lee JS, Hao P, Yao SQ, Ding K, Li Z

Angewandte Chemie (International ed. in English)

APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.

Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK

Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.

Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, Xu A, Lam KS, Chan KH

Molecular neurodegeneration

Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity.

Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A