Role Faculty Location UCSF at Mission Bay Category Clinical Specialties Pediatrics Education Residency, - School of Medicine, University of California, San Francisco Publications Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM Outcomes for extremely premature infants. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM The pharmacogenetics research network: from SNP discovery to clinical drug response. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I, Pharmacogenetics Research Network Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Washington CB, Giacomini KM, Brett CM Role of organic cation transporters in drug absorption and elimination. Zhang L, Brett CM, Giacomini KM Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Ramanathan VK, Brett CM, Giacomini KM Taurine transport in cultured choroid plexus. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Ramanathan VK, Hui AC, Brett CM, Giacomini KM Saturable disposition of taurine in the rat cerebrospinal fluid. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Gutierrez MM, Brett CM, Giacomini KM Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Washington CB, Giacomini KM, Brett CM The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. Washington CB, Brett CM, Wu X, Giacomini KM Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Chung SJ, Ramanathan V, Giacomini KM, Brett CM Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM Nucleoside transport in brush border membrane vesicles from human kidney. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM The young lamb can increase cardiovascular performance during isoflurane anesthesia. Brett CM, Teitel DF, Heymann MA, Rudolph AM Pre-induction of anesthesia in pediatric patients with nasally administered sufentanil. Henderson JM, Brodsky DA, Fisher DM, Brett CM, Hertzka RE Short-term hemodynamic effects of captopril in infants with congestive heart failure. Shaddy RE, Teitel DF, Brett C Thiopental dose-response relations in unpremedicated infants, children, and adults. Brett CM, Fisher DM The cardiovascular effects of isoflurane in lambs. Brett CM, Teitel DF, Heymann MA, Rudolph AM Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies. Fisher DM, Robinson S, Brett CM, Perin G, Gregory GA
