Role Faculty Location UCSF at Mission Bay Category Clinical Specialties Pediatrics Education Residency, - School of Medicine, University of California, San Francisco Publications Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2). Riselli AM, Yee SW, Yang J, Brett CM, Trumbach K, Zhou X, Liu R, Liang X, Lai Y, Huo R, Xue Y, Shen H, Zhang L, Yang X, Liu Q, Huang SM, Giacomini KM . Clinical pharmacology and therapeutics . Apr 1, 2025 Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM . Journal of veterinary pharmacology and therapeutics . May 17, 2023 The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM . Clinical pharmacokinetics . Jun 1, 2016 The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM . Clinical pharmacokinetics . Apr 1, 2016 Outcomes for extremely premature infants. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ . Anesthesia and analgesia . Jun 1, 2015 Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM . Clinical pharmacology and therapeutics . May 22, 2014 Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM . Journal of pharmaceutical sciences . May 6, 2013 The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM . Clinical pharmacology and therapeutics . Oct 17, 2012 Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM . Pharmacogenetics and genomics . Jul 1, 2009 Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM . Clinical pharmacology and therapeutics . Jul 4, 2007 Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM . Clinical pharmacology and therapeutics . Jul 4, 2007 Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM . The Journal of clinical investigation . May 1, 2007 The pharmacogenetics research network: from SNP discovery to clinical drug response. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I, Pharmacogenetics Research Network . Clinical pharmacology and therapeutics . Mar 1, 2007 Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM . Molecular pharmacology . Aug 24, 2006 Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM . The Journal of pharmacology and experimental therapeutics . May 15, 2006 PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM . Pharmacological reviews . Mar 1, 2006 The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM . American journal of physiology. Renal physiology . Nov 15, 2005 Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM . Pharmacogenetics and genomics . Apr 1, 2005 Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM . The pharmacogenomics journal . Jan 1, 2005 No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL . Clinical pharmacology and therapeutics . Nov 1, 2003 Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Washington CB, Giacomini KM, Brett CM . Pharmaceutical research . Jul 1, 1998 Role of organic cation transporters in drug absorption and elimination. Zhang L, Brett CM, Giacomini KM . Annual review of pharmacology and toxicology . Jan 1, 1998 Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Ramanathan VK, Brett CM, Giacomini KM . Biochimica et biophysica acta . Nov 13, 1997 Taurine transport in cultured choroid plexus. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM . Pharmaceutical research . Apr 1, 1997 Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Ramanathan VK, Hui AC, Brett CM, Giacomini KM . Pharmaceutical research . Jun 1, 1996 Saturable disposition of taurine in the rat cerebrospinal fluid. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM . The Journal of pharmacology and experimental therapeutics . Feb 1, 1996 Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Gutierrez MM, Brett CM, Giacomini KM . Pharmaceutical biotechnology . Jan 1, 1996 Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Washington CB, Giacomini KM, Brett CM . Pharmaceutical biotechnology . Jan 1, 1996 The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. Washington CB, Brett CM, Wu X, Giacomini KM . The Journal of pharmacology and experimental therapeutics . Jul 1, 1995 Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Chung SJ, Ramanathan V, Giacomini KM, Brett CM . Biochimica et biophysica acta . Jul 13, 1994 Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM . Drug metabolism and disposition: the biological fate of chemicals . Jul 1, 1993 Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM . Pharmaceutical research . Mar 1, 1993 Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM . The Journal of biological chemistry . May 5, 1992 Nucleoside transport in brush border membrane vesicles from human kidney. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM . Biochimica et biophysica acta . Mar 23, 1992 The young lamb can increase cardiovascular performance during isoflurane anesthesia. Brett CM, Teitel DF, Heymann MA, Rudolph AM . Anesthesiology . Nov 1, 1989 Pre-induction of anesthesia in pediatric patients with nasally administered sufentanil. Henderson JM, Brodsky DA, Fisher DM, Brett CM, Hertzka RE . Anesthesiology . May 1, 1988 Short-term hemodynamic effects of captopril in infants with congestive heart failure. Shaddy RE, Teitel DF, Brett C . American journal of diseases of children (1960) . Jan 1, 1988 Thiopental dose-response relations in unpremedicated infants, children, and adults. Brett CM, Fisher DM . Anesthesia and analgesia . Oct 1, 1987 The cardiovascular effects of isoflurane in lambs. Brett CM, Teitel DF, Heymann MA, Rudolph AM . Anesthesiology . Jul 1, 1987 Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies. Fisher DM, Robinson S, Brett CM, Perin G, Gregory GA . Anesthesiology . Dec 1, 1985
