Peri-Operative and Critical Care Outcome research group (POCCO)


POCCO translational approach helps us to identify and deploy new therapeutic interventions and strategies to protect patients from adverse outcomes.   

Critical illnesses (e.g. sepsis, COVID, major trauma) and major surgery are associated with important short and long term morbidity and/or mortality. POCCO investigators promote translational research with the goal of implementing precision medicine by refining diagnostic and therapeutic strategies in the field of perioperative and critical care medicine.

POCCO is a multidisciplinary team that includes physician scientists, basic scientists, clinical researchers, scientists, epidemiologists, and biostatisticians. Skill sets present include deep expertise in data management, clinical trial design and execution, biostatistical analysis. Our group has a deep expertise in translational research. We develop translational research programs, from theoretical data science to implementation and validation through clinical trials, with the goal of addressing important questions in the field of critical care medicine, emergency medicine and peri-operative care.

POCCO is consequently ideally placed to tackle an injury mechanism/pattern from basic science to the implementation of interventional clinical trials.

POCCO Research Domains
  • Acute kidney injury
  • Sepsis
  • Trauma
  • Cardiovascular disease and dysfunction
  • Organ support
  • Surgical and anesthetic stress response
  • Organ injury during solid organ transplantation
  • Long term outcomes after critical illness
  • Short- and long-term outcomes after surgery
Active Projects
About Us

POCCO consists of translational and clinical researchers, scientists, epidemiologists, and biostatisticians collaborating on clinical and translational research projects in the field of critical care medicine and perioperative medicine.

  Matthieu Legrand, MD, PhD

  UCSF Anesthesia



  Romain Pirracchio, MD, PhD

  UCSF Anesthesia



  Michael Bokoch , MD, PhD

  UCSF Profile  Dr. Bokoch is an anesthesiologist specializing in the care of patients undergoing solid-organ transplantation (liver and kidney) and vascular surgery, as well as translational research. His research interests include interventions to reduce acute kidney injury after high-risk surgery, biomarkers of organ injury, and the role of the vascular endothelium in ischemia-reperfusion injury and end-stage liver disease. He is a co-PI and founder of the Transplant Anesthesia Research Group.

  Dieter Adelmann, MD, PhD

  UCSF Anesthesia



  Rishi Kothari, MD

  UCSF Anesthesia Dr Kothari is a Liver transplant and general anesthesiologist. His clinical interests are in short and medium term outcomes after liver and kidney transplantation and non-primary non-clinical interests in clinical informatics and EHR facilitation of clinical research.

  Orestes Mavrothalassitis, MD

  UCSF Profile



  Daniel Lazzareschi, MD

  UCSF Profile



  Catherine Chiu, MD

  UCSF Profile



  Andrew Bishara, MD

  UCSF Profile



  Nikitha Reddy, Clinical research coordinator

  Nikitha graduated from UC Berkeley and received a double major in Molecular/Cell   biology and Psychology.


  Nick Fong, Data analyst

  Nick is a data analyst working for POCCO. His interests lie at the intersection of   medicine and data science.


  Jilene Sturgess-Daprato, Clinical research coordinator

 Jillene received a Bachelor of Science in Exercise Biology and Minor in Nutrition from UC Davis. She graduated from Touro University California with a Master of Science in Medical Health Science. Her current interests are Orthopaedics, Trauma and Critical Care, and Sports Medicine.

 Emily Bi, Clinical research coordinator

 Emily graduated from UC Berkeley with a double major in Molecular/Cell Biology and Art Practice.


Rachel Hill, Clinical research coordinator

 Rachel graduated from the University of Southern California in 2016 with degrees in Accounting and Business Administration. She worked with the Transplant Anesthesia Research Group as an Assistant Research Coordinator from 2019 to 2020, with a focus on the MHALT trial. Rachel began medical school at Weill Cornell Medical College in 2020.

 Joseph Mellen, Clinical research coordinator

 Joseph is a 4th year medical student who is applying into anesthesiology. He graduated from the Enlisted to Medical Degree Preparatory Program at George Mason University with a Master of Science in Biology. He is a 7-year Air Force veteran, and a current Air Force Health Profession Scholarship Program recipient.

 Christopher Ansay, Clinical research coordinator

 Christopher graduated from UCLA with a Biology degree and is currently attending UCSF for medical school.

POCCO Support
  • Administrative Core
  • Biostatistics and Data Management Core (data management, biostatistics, design and implementation of observational and interventional trials).
  • Clinical Research Biospecimen Core Lab (receives, processes, biobanks biospecimens from the 4CTI investigations)
  • Specimen Processing

-POCCO is collaborating with several research labs with strong interconnections

-Artificial intelligence and machine learning Lab (Link:

-Preclinical science Lab (Link:

-Organ transplantation Lab (Link)


-Research Training in POCCO

-POCCO offers research training for residents in the research track, research fellowship, visiting fellows and academics, interns and postdoc.

  1. Optimizing the Design and Analysis of Future AKI Trials. J Am Soc Nephrol. 2022 Jul 13. Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO. Pubmed

  2. Differences in HADS and SF-36 scores 1 year after critical illness in COVID-19 patients. Intensive Care Med. 2022 Jul 08. Tallarico RT, Deniau B, Fong N, Ghosn J, Legrand M, French-COVID and the FROG-ICU Investigators. Pubmed

  3. Fluids, vasopressors, and acute kidney injury after major abdominal surgery between 2015 and 2019: a multicentre retrospective analysis. Br J Anaesth. 2022 Jun 07. Chiu C, Fong N, Lazzareschi D, Mavrothalassitis O, Kothari R, Chen LL, Pirracchio R, Kheterpal S, Domino KB, Mathis M, Legrand MPubmed

  4. Ten tips to optimize vasopressors use in the critically ill patient with hypotension. Intensive Care Med. 2022 Jun; 48(6):736-739. Legrand M, Zarbock A. Pubmed

  5. Digital health and artificial intelligence in kidney research: a report from the 2020 Kidney Disease Clinical Trialists (KDCT) meeting. Nephrol Dial Transplant. 2022 Mar 25; 37(4):620-627. Yi TW, Laing C, Kretzler M, Nkulikiyinka R, Legrand M, Jardine M, Rossignol P, Smyth B. Pubmed

  6. Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target. Int J Mol Sci. 2022 Mar 14; 23(6). Boutin L, Dépret F, Gayat E, Legrand M, Chadjichristos CE. Pubmed

  7. Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission. J Crit Care. 2022 Jan 21; 69:153983. Schnell D, Bourmaud A, Reynaud M, Rouleau S, Merdji H, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Darmon M. Pubmed

  8. Usefulness of lactate albumin ratio at admission to predict 28-day mortality in critically ill severely burned patients: A retrospective cohort study. Burns. 2022 Jan 05. Dudoignon E, Quennesson T, De Tymowski C, Moreno N, Coutrot M, Chaussard M, Guillemet L, Abid S, Fratani A, Ressaire Q, Cupaciu A, Weinmann V, Pharaboz A, Benyamina M, Mebazaa A, Legrand M, Depret F, Deniau B, PRONOBURN Group. Pubmed

  9. Overcoming barriers in the design and implementation of clinical trials for Acute Kidney Injury: a report from the 2020 Kidney Disease Clinical Trialists meeting. Nephrol Dial Transplant. 2022 Jan 12. Lazzareschi D, Mehta RL, Dember LM, Bernholz J, Turan A, Sharma A, Kheterpal S, Parikh CR, Ali O, Schulman IH, Ryan A, Feng J, Simon N, Pirracchio R, Rossignol P, Legrand MPubmed

  10. Further evidence in support of closed ICUs. Anaesth Crit Care Pain Med. 2021 Nov 05; 40(6):100978. Legrand M, Aldrich M. Pubmed

  11. Outcome of surgical patients during the first wave of the COVID-19 pandemic in US hospitals. Br J Anaesth. 2021 Oct 01. Mavrothalassitis O, Pirracchio R, Fong N, Lazzareschi D, Sharma A, Vaughn MT, Mathis M, Legrand MPubmed

  12. Kidney Replacement Therapy in the ICU: Less Is More (Death)? Am J Kidney Dis. 2021 Jul 07. Legrand M, Liu KD. Pubmed

  13. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021 Jul 05. Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pubmed

  14. Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol. 2021 Apr 01; 34(2):71-76. Chiu C, Legrand M. Pubmed

  15. Anticoagulation strategies in continuous renal replacement therapy. Semin Dial. 2021 Mar 08. Pubmed

  16. Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 Jan 22. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. Pubmed

  17. Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol. 2021 Jan 21. Chiu C, Legrand M. Pubmed

  18. Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers? Ann Intensive Care. 2021 Jan 06; 11(1):1. Joffre J, Legrand M. Pubmed

  19. Goal-directed therapy and development of acute kidney injury. Eur J Anaesthesiol. 2021 Jan; 38(1):96-97. Joosten A, Alexander B, Duranteau J, Legrand M. Pubmed

  20. The Yin and Yang of the Renin-angiotensin-aldosterone system in AKI. Am J Respir Crit Care Med. 2020 Dec 24. Legrand M, Bokoch MP. Pubmed

  21. Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains. Crit Care Med. 2020 Dec; 48(12):1922-1923. Legrand M, Liu K. Pubmed

  22. Complications in Patients With COVID-19. JAMA Cardiol. 2020 Nov 18. Legrand M. Pubmed

  23. Response of US hospitals to elective surgical cases in the COVID-19 pandemic. Br J Anaesth. 2020 Oct 19. Pirracchio R, Mavrothalassitis O, Mathis M, Kheterpal S, Legrand M. Pubmed

  24. Cardiovascular Consequences of Acute Kidney Injury. Reply. N Engl J Med. 2020 09 10; 383(11):1094. Legrand M, Rossignol P. Pubmed

  25. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Nephron. 2020; 144(12):655-661. Khorashadi M, Beunders R, Pickkers P, Legrand M. Pubmed

  26. The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Trials. 2020 Jul 01; 21(1):601. Legrand M, Oufella HA, De Backer D, Duranteau J, Leone M, Levy B, Rossignol P, Vicaut E, Dépret F. Pubmed

  27. Cardiovascular Consequences of Acute Kidney Injury. N Engl J Med. 2020 06 04; 382(23):2238-2247. Legrand M, Rossignol P. Pubmed

  28. Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. Crit Care Med. 2020 Jun; 48(6):822-829. Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Meert AP, Borcoman E, Bisbal M, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L. Pubmed

  29. Outcome and characteristics of invasive fungal infections in critically ill burn patients: A multicenter retrospective study. Mycoses. 2020 Jun; 63(6):535-542. Maurel V, Denis B, Camby M, Jeanne M, Cornesse A, Glavnik B, Alanio A, Rousseau AF, Lefloch R, Lagrange-Xelot M, Textoris J, Wiramus S, de Tymowski C, Legrand M. Pubmed

  30. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 Jun 15; 204(12):3339-3350. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Pubmed

  31. Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med. 2020 06; 46(6):1105-1108. Leisman DE, Deutschman CS, Legrand M. Pubmed

  32. Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients. Crit Care. 2020 04 22; 24(1):168. Dépret F, Amzallag J, Pollina A, Fayolle-Pivot L, Coutrot M, Chaussard M, Santos K, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Benyamina M, Guillemet L, Deniau B, Mebazaa A, Gayat E, Farny B, Textoris J, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L. Pubmed

  33. Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial. Eur J Anaesthesiol. 2020 04; 37(4):333-334. Maurel V, Legrand M, Bourgeois E, Masse AL, Bergeron A, Binakdane F, Ntahe A, Legouge M, Vicaut E, Plaud B. Pubmed

  34. Point-of-care serum kalemia measurement accuracy. Eur J Emerg Med. 2020 04; 27(2):150-151. Depret F, Bonnart Latry D, Gayat E, Plaisance P, Legrand M. Pubmed

  35. Should we ban hydroethyl starches from the operating theatre? PRO. Anaesth Crit Care Pain Med. 2020 Apr; 39(2):187-188. Legrand M, Pirracchio R. Pubmed

  36. Management of severe thermal burns in the acute phase in adults and children. Anaesth Crit Care Pain Med. 2020 04; 39(2):253-267. Legrand M, Barraud D, Constant I, Devauchelle P, Donat N, Fontaine M, Goffinet L, Hoffmann C, Jeanne M, Jonqueres J, Leclerc T, Lefort H, Louvet N, Losser MR, Lucas C, Pantet O, Roquilly A, Rousseau AF, Soussi S, Wiramus S, Gayat E, Blet A. Pubmed

  37. Utility of anaerobic bottles for the diagnosis of bloodstream infections. BMC Infect Dis. 2020 Feb 14; 20(1):142. Lafaurie M, d'Anglejan E, Donay JL, Glotz D, Sarfati E, Mimoun M, Legrand M, Oksenhendler E, Bagot M, Valade S, Bercot B, Molina JM. Pubmed

  38. Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Ann Intensive Care. 2020 Feb 12; 10(1):22. Khorashadi M, Bokoch MP, Legrand M. Pubmed

  39. Physiological response to fluid resuscitation with Ringer lactate versus Plasmalyte in critically ill burn patients. J Appl Physiol (1985). 2020 03 01; 128(3):709-714. Chaussard M, Dépret F, Saint-Aubin O, Benyamina M, Coutrot M, Jully M, Oueslati H, Fratani A, Cupaciu A, Poniard A, Asehnoune K, Dimby SF, Mebazaa A, Houze P, Legrand M. Pubmed

  40. Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits? Intensive Care Med. 2020 03; 46(3):552-553. Legrand M, Alexander B, Joosten A. Pubmed

  41. PenKid measurement at admission is associated with outcome in severely ill burn patients. Burns. 2020 09; 46(6):1302-1309. Dépret F, Polina A, Amzallag J, Fayolle-Pivot L, Coutrot M, Chaussard M, Struck J, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Soussi S, Benyamina M, Guillemet L, Mebazaa A, Textoris J, Legrand M. Pubmed

  42. Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. Cardiorenal Med. 2020; 10(2):85-96. Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergová Pavkova M, Jarkovský J, Spinar J, Tomandlova M, Dastych M, Ince C, Helanova K, Tesak M, Helan M, Lokaj P, Legrand M. Pubmed

  43. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019 Dec 23; 23(1):421. Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, Barbier F, Constantin JM, Clavier T, du Cheyron D, Terzi N, Sauneuf B, Guerot E, Lafon T, Herbland A, Megarbane B, Leclerc T, Mallet V, Pirracchio R, Legrand M. Pubmed

  44. Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section. Intensive Care Med Exp. 2019 Dec 07; 7(1):69. Ostermann M, Schneider A, Rimmele T, Bobek I, van Dam M, Darmon M, Forni L, Joannes-Boyau O, Joannidis M, Legrand M, Prowle J, Zarbock A, Hoste E. Pubmed

  45. Tailoring treatment of hyperkalemia. Nephrol Dial Transplant. 2019 12 01; 34(Suppl 3):iii62-iii68. Coutrot M, Dépret F, Legrand M. Pubmed

  46. One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study. Crit Care Med. 2019 12; 47(12):e953-e961. Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Launay JM, Ishihara S, Sato N, Mebazaa A, Gayat E. Pubmed

  47. Rev Infirm. 2019 Dec; 68(256):17. Lefort H, Legrand M. Pubmed

  48. The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy. Intensive Care Med. 2020 03; 46(3):510-512. Legrand M, Prowle JR, Forni LG. Pubmed

  49. Monitoring tissue perfusion: a pilot clinical feasibility and safety study of a urethral photoplethysmography-derived perfusion device in high-risk patients. J Clin Monit Comput. 2020 Oct; 34(5):961-969. Dépret F, Leone M, Duclos G, Futier E, Montagne M, Legrand M, Allaouchiche B. Pubmed

  50. Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery. Crit Care. 2019 11 04; 23(1):343. Redant S, Legrand M, Langman Y, Aguilar AG, Angoulvant F, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM. Pubmed

  51. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway. JACC Basic Transl Sci. 2019 Oct; 4(6):717-732. Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F, Launay JM, Kane B, Kinugasa S, Prakoura N, Vandermeersch S, Cohen-Solal A, Delcayre C, Samuel JL, Mehta R, Gayat E, Mebazaa A, Chadjichristos CE, Legrand M. Pubmed

  52. Urgent need for a randomized controlled trial with only septic patients! Ann Intensive Care. 2019 Oct 21; 9(1):121. Redant S, Legrand M, Langman Y, Garcia Aguilar A, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM. Pubmed

  53. Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study. Burns. 2020 05; 46(3):630-638. de Tymowski C, Pallado S, Anstey J, Depret F, Moreno N, Benyamina M, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Chaussard M, Guillemet L, Dudoignon E, Mimoun M, Chaouat M, Mebazaa A, Legrand M, Soussi S. Pubmed

  54. Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Anaesth Crit Care Pain Med. 2019 12; 38(6):647-656. Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B. Pubmed

  55. Reply to: "Potential role of ketamine in burn-associated cholestasis". J Hepatol. 2019 12; 71(6):1276-1277. Legrand M, de Tymowski C, Hodjat K, Mallet V. Pubmed

  56. Correction to: Recruiting the microcirculation in septic shock. Ann Intensive Care. 2019 Sep 24; 9(1):107. Legrand M, De Backer D, Dépret F, Ait-Oufella H. Pubmed

  57. Management of Burns. N Engl J Med. 2019 09 19; 381(12):1188-1189. Legrand M, Dépret F, Mallet V. Pubmed

  58. Recruiting the microcirculation in septic shock. Ann Intensive Care. 2019 Sep 11; 9(1):102. Legrand M, De Backer D, Dépret F, Ait-Oufella H. Pubmed

  59. Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle. Sci Rep. 2019 08 27; 9(1):12378. Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N. Pubmed

  60. Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Intensive Care Med. 2019 09; 45(9):1231-1240. Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B. Pubmed

  61. Understanding the renal response to brain injury. Intensive Care Med. 2019 08; 45(8):1112-1115. Legrand M, Sonneville R. Pubmed

  62. Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments. J Emerg Med. 2019 07; 57(1):102-103. Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E Pubmed

  63. Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU. Eur J Trauma Emerg Surg. 2019 Jun 18. Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M Pubmed

  64. Is Nitric Oxide Nephro- or Cardioprotective? Am J Respir Crit Care Med. 2019 06 01; 199(11):1441-1442. Coutrot M, Dépret F, Legrand M. Pubmed

  65. Contributing factors and outcomes of burn-associated cholestasis. J Hepatol. 2019 09; 71(3):563-572. de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M. Pubmed

  66. Acute Kidney Injury Related to Sepsis-Reply. JAMA. 2019 05 14; 321(18):1828-1829. Legrand M, Kellum JA. Pubmed

  67. Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis. 2019 Aug; 38(8):1457-1461. Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A. Pubmed

  68. Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. JAMA Netw Open. 2019 05 03; 2(5):e193215. Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M. Pubmed

  69. Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings? Nephron. 2019; 143(3):179-183. Dudoignon E, Dépret F, Legrand M. Pubmed

  70. Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial). Trials. 2019 Mar 05; 20(1):160. Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E. Pubmed

  71. Management of hyperkalemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28; 9(1):32. Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M. Pubmed

  72. Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic ßLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol. BMJ Open. 2019 02 19; 9(2):e024561. Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C. Pubmed

  73. Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study. Shock. 2019 02; 51(2):153-160. Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, Legrand M. Pubmed

  74. Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn. Front Immunol. 2018; 9:3091. Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J. Pubmed

  75. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Crit Care. 2018 12 21; 22(1):354. Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M Laterre PF. Pubmed

  76. Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study. Mycoses. 2019 Mar; 62(3):237-246. Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S. Pubmed

  77. Serum Creatinine in the Critically Ill Patient With Sepsis. JAMA. 2018 Dec 11; 320(22):2369-2370. Legrand M, Kellum JA. Pubmed

  78. Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. Int J Infect Dis. 2019 Feb; 79:179-184. Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Pubmed

  79. Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis. Am J Infect Control. 2019 04; 47(4):435-438. Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M. Pubmed

  80. Hydroxocobalamin as a Cause of Oxalate Nephropathy. Kidney Int Rep. 2019 Jan; 4(1):185. Legrand M. Pubmed

  81. French intensive care unit organisation. Anaesth Crit Care Pain Med. 2018 12; 37(6):625-627. Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X. Pubmed

  82. CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit? Anaesth Crit Care Pain Med. 2018 12; 37(6):519-520. Schetz M, Legrand M. Pubmed

  83. Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol. Am J Emerg Med. 2019 05; 37(5):1004. Montassier E, Legrand M, Rossignol P, Potel G. Pubmed

  84. Prediction of major adverse kidney events in critically ill burn patients. Burns. 2018 12; 44(8):1887-1894. Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M. Pubmed

  85. Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Intensive Care Med. 2018 Nov; 44(11):1904-1913. Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D. Pubmed

  86. Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients. Burns. 2018 12; 44(8):2106-2107. Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S. Pubmed

  87. Negative trials in critical care medicine and the hurdles. Lancet Respir Med. 2018 10; 6(10):e53. Legrand M. Pubmed

  88. New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Int J Cardiol. 2018 Sep 01; 266:95-99. Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A. Pubmed

  89. Early Hemodynamic Management of Critically Ill Burn Patients. Anesthesiology. 2018 Sep; 129(3):583-589. Soussi S, Dépret F, Benyamina M, Legrand M. Pubmed

  90. Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis. Biomarkers. 2018 Dec; 23(8):766-772. Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E. Pubmed

  91. Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study. Kidney Int Rep. 2018 11; 3(6):1424-1433. Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M. Pubmed

  92. Hemodynamic management of critically ill burn patients: an international survey. Crit Care. 2018 08 17; 22(1):194. Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M. Pubmed

  93. Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Anaesth Crit Care Pain Med. 2018 08; 37(4):299-301. Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X. Pubmed

  94. Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone. J Burn Care Res. 2018 06 13; 39(4):580-584. Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K. Pubmed

  95. When ethics collides with a legal gap in emergency life-threatening conditions. Br J Anaesth. 2018 Aug; 121(2):513-514. Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B. Pubmed

  96. Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury. Intensive Care Med. 2018 May; 44(5):598-605. Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M. Pubmed

  97. Could resuscitation be based on microcirculation data? Yes. Intensive Care Med. 2018 Jun; 44(6):944-946. Legrand M, Ait-Oufella H, Ince C. Pubmed

  98. Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. mBio. 2018 04 24; 9(2). Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A. Pubmed

  99. Cardiac output and CVP monitoring… to guide fluid removal. Crit Care. 2018 04 12; 22(1):89. Legrand M, Soussi S, Depret F. Pubmed

  100. Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Anaesth Crit Care Pain Med. 2018 12; 37(6):551-556. Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M. Pubmed

  101. Tolvaptan in Later-Stage Polycystic Kidney Disease. N Engl J Med. 2018 02 01; 378(5):488. De Tymowski C, Legrand M. Pubmed

  102. Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge. Crit Care Med. 2018 02; 46(2):e102-e110. Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T. Pubmed

  103. Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report. Crit Care. 2018 01 29; 22(1):24. Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M. Pubmed

  104. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Crit Care. 2018 01 18; 22(1):8. Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A. Pubmed

  105. Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable? Shock. 2017 11; 48(5):532-538. Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M. Pubmed

  106. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Clin Res Cardiol. 2018 Mar; 107(3):214-221. Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, Plaisance P, Spinar J, Kosiborod M, Mebazaa A, Gayat E. Pubmed

  107. Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms. Burns. 2018 May; 44(3):544-548. Serror K, Chaouat M, Legrand M, Depret F, Haddad J, Malca N, Mimoun M, Boccara D. Pubmed

  108. Pressure guided surgery of compartment syndrome of the limbs in burn patients. Ann Burns Fire Disasters. 2017 Sep 30; 30(3):193-197. Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K. Pubmed

  109. Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients. Crit Care. 2017 Sep 26; 21(1):245. Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M. Pubmed

  110. Intravenous iloprost to recruit the microcirculation in septic shock patients? Intensive Care Med. 2018 01; 44(1):121-122. Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M. Pubmed

  111. Intravenous hydroxocobalamin and crystal nephropathy. Nat Rev Nephrol. 2017 09; 13(9):593. Legrand M, Mallet V. Pubmed

  112. Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit. J Hosp Infect. 2017 Nov; 97(3):226-233. Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Pubmed

  113. On-line plasma lactate concentration monitoring in critically ill patients. Crit Care. 2017 06 16; 21(1):151. De Tymowski C, Soussi S, Depret F, Legrand M. Pubmed

  114. A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Nephron. 2017; 137(4):273-276. Dépret F, Prud'homme M, Legrand M. Pubmed

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