Pan Lab

About

Understand the tissue injury mechanisms after CNS trauma and search regimen for repair and recovery of sensory and motor function 

 

People

Jonathan Pan, MD, PhD

Zhihua Sun, MD, PhD

Jiandong Gao, MD, PhD

Publications

Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan J.Z., Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein PR, Manley GT, Dhall SS, Ferguson AR, Oldham MC, Bresnahan JC, Beattie MSDiagnostic blood RNA profiles for human acute spinal cord injury. J Exp Med. 2021 Mar 01; 218(3).

Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan J.Z., Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF.Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study. J Clin Neurosci. 2020 Nov 25.

Li R, Lai IK, Pan J.Z., Zhang P, Maze M.Dexmedetomidine Exerts an Anti-inflammatory Effect via a2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Anesthesiology. 2020 08; 133(2):393-407.

Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan J.Z., Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, Kuo YH, Taggard D, Talbott JF, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Dhall SS.Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics. Neurosurg Focus. 2020 05 01; 48(5):E6.

Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan J.Z..Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Br J Anaesth. 2019 12; 123(6):827-838.

Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan J.Z., Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS.Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study. World Neurosurg. 2020 Jan; 133:e391-e396.

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan J.Z., Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS.In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 08 01; 85(2):E401-E402.

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan J.Z., Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS.Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 08 01; 85(2):199-203.

Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan J.Z., Manley GT, Whetstone WD.Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury. Neurosurgery. 2018 06 01; 82(6):870-876.

Genomics and Proteomic Techniques.. Methods Enzymol. 2018; 603:221-235.

Between a ROCK and an IR Place.. Anesth Analg. 2018 03; 126(3):750-751.

Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.. Neurosurgery. 2016 Nov; 79(5):708-714.

Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries.. World Neurosurg. 2016 Dec; 96:72-79.

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J.Z., Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS.182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression. Neurosurgery. 2016 Aug; 63 Suppl 1:172.

Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J.Z., Manley GT, Dhall SS.Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 May 03.

Changes in the Bispectral Index in Response to Loss of Consciousness and No Somatic Movement to Nociceptive Stimuli in Elderly Patients. Chin Med J (Engl). 2016 Feb 20; 129(4):410-6.

Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury. J Neurotrauma. 2016 05 15; 33(10):954-62.

Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Dec 15; 32(24):1958-67.

Talbott J.F., Whetstone W.D., Readdy W., Ferguson A.R., Bresnahan J.C., Saigal R., Jawryluk G.W., Beattie M.S., Mabray M.C., Pan J.Z., Manley G.T., Dhall S.S. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine[1] . 2015 Jul 10:1-10.

Readdy W.J., Whetstone W.D., Ferguson A.R., Talbott J.F., Inoue T., Saigal R., Bresnahan J.C., Beattie M.S. Pan J.Z., Manley G.T. and Dhall S.S. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. Journal of Neurosurgery: Spine, in press

Hawryluk, G.W., Whetstone, W., Saigal, R., Ferguson, A., Talbott, J., Bresnahan, J., Pan, J.Z., Dhall, S., Beattie, M., Manley, G. Higher Mean Arterial Blood Pressures Following Human Spinal Cord Injury Correlate With The Greater Neurological Recovery. Journal of Neurotrauma,  2015, Feb 10.

Ye X.F., Lian Q.Q., Eckenhoff M.F., Eckenhoff R.G. Pan J.Z. Differential General Anesthetic Effects on Microglial Cytokine Expression. PLoS One. 2013;8(1): PMID: 23382826.

Pan J.Z., Xi J., Eckenhoff M.F., Eckenhoff R.G. Inhaled anesthetics elicit region-specific changes in protein expression in mammalian brain. Proteomics. 2008 Jul;8(14):2983-92.

Pan J.Z., Xi J., Tobias J.W., Eckenhoff M.F., Eckenhoff R.G. Halothane binding proteome in human brain cortex. Journal of Proteome Research. Feb 2007;6(2):582-92.

Pan J.Z., Eckenhoff R.G., Eckenhoff M.F. Limitations of microarray studies. Anesth. Analg. 2007 May;104(5):1300-1.

Pan J.Z., Wei H., Hecker J.G, Tobias J., Eckenhoff R.G., and Eckenhoff M.F. DNA transcript profile of halothane and isoflurane in rat brain. Pharmacogenet. and Genomics.March, 2006, 16(3):171-82.

Pan J.Z., Jörnsten R, Hart R.P. Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches. Physiol Genomics. 2004 Apr 13;17(2):201-14. PMID: 14970362

Jones T.B., Basso D.M., Sodhi A., Pan J.Z., Hart R.P., MacCallum R.C., Lee S., Whitacre C.C. and Popovich P.G. Pathological Central Nervous System Autoimmune Disease Triggered by Traumatic Spinal Cord Injury: Implications for autoimmune Vaccine Therapies. J. Neuroscience.April 1, 2002, 22(7): 2690-270. PMID: 11923434

Pan J.Z., Ni L., Sodhi A., Aguanno A., Young W. and Hart R.P. Cytokine Activity Contributes to Induce Inflammatory Cytokine mRNAs in Spinal Cord following Contusion. J. Neurosci. Res.2002, 68: 315-322.  PMID: 12111861

Contact Us

Zuckerberg San Francisco General Hospital, University of California, San Francisco
Bldg 1, Room 233, Brain and Spinal Injury Center (BASIC),
San Francisco, Ca 94110

Email: [email protected]
Lab phone: 415-206-4467
Fax: 415-206-6614