Jeremie Joffre, PhD, MD

Postdoctoral Scholar
Publications: 
Lutgens E, Joffre J, van Os B, Ait-Oufella H. Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies. Atherosclerosis. 2021 Oct; 335:98-109.
Ait-Oufella H, Yu M, Kotti S, Georges A, Vandestienne M, Joffre J, Roubille F, Angoulvant D, Santos-Zas I, Tedgui A, Gibot S, Derive M, Danchin N, Bouatia-Naji N, Simon T. Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study. Int J Cardiol. 2021 Sep 15.
Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, Oualha M, Voiriot G, Jouan Y, Joffre J, Huel F, De Prost N, Silva S, Azabou E, Radermacher P. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021 Jul 03; 11(1):104.
Joffre J, Hellman J. Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Antioxid Redox Signal. 2021 Apr 09.
Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 03 01; 49(3):e315-e326.
Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J. ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Shock. 2021 03 01; 55(3):349-356.
Vandestienne M, Zhang Y, Santos-Zas I, Al-Rifai R, Joffre J, Giraud A, Laurans L, Esposito B, Pinet F, Bruneval P, Raffort J, Lareyre F, Vilar J, Boufenzer A, Guyonnet L, Guerin C, Clauser E, Silvestre JS, Lang S, Soulat-Dufour L, Tedgui A, Mallat Z, Taleb S, Boissonnas A, Derive M, Chinetti G, Ait-Oufella H. TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm. J Clin Invest. 2021 01 19; 131(2).
Joffre J, Legrand M. Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers? Ann Intensive Care. 2021 Jan 06; 11(1):1.
Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020 08 01; 202(3):361-370.
Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 06 15; 204(12):3339-3350.
Bigé N, Lavillegrand JR, Dang J, Attias P, Deryckere S, Joffre J, Dubée V, Preda G, Dumas G, Hariri G, Pichereau C, Baudel JL, Guidet B, Maury E, Boelle PY, Ait-Oufella H. Bedside prediction of intradialytic hemodynamic instability in critically ill patients: the SOCRATE study. Ann Intensive Care. 2020 Apr 22; 10(1):47.
Hariri G, Laurent C, Lavillegrand JR, Riviere S, Joffre J, Guidet B, Fain O, Mekinian A, Ait-Oufella H. Combination vasodilator therapy improves skin microvascular blood but do not restore endothelial function in systemic sclerosis. Autoimmun Rev. 2020 Mar; 19(3):102467.
Baudel JL, Vigneron C, Pras-Landre V, Joffre J, Marjot F, Ait-Oufella H, Bigé N, Maury E, Guidet B, Fain O, Mekinian A. Transfusion-related acute lung injury (TRALI) after intravenous immunoglobulins: French multicentre study and literature review. Clin Rheumatol. 2020 Feb; 39(2):541-546.
Hariri G, Bourcier S, Marjanovic Z, Joffre J, Lemarié J, Lavillegrand JR, Charue D, Duflot T, Bigé N, Baudel JL, Maury E, Mohty M, Guidet B, Bellien J, Blanc-Brude O, Ait-Oufella H. Exploring the microvascular impact of red blood cell transfusion in intensive care unit patients. Crit Care. 2019 Aug 30; 23(1):292.
Dumas G, Lavillegrand JR, Joffre J, Bigé N, de-Moura EB, Baudel JL, Chevret S, Guidet B, Maury E, Amorim F, Ait-Oufella H. Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters. Crit Care. 2019 Jun 10; 23(1):211.
Joffre J, Dumas G, Aegerter P, Dubée V, Bigé N, Preda G, Baudel JL, Maury E, Guidet B, Ait-Oufella H, CUB-Réa Network . Epidemiology of infective endocarditis in French intensive care units over the 1997-2014 period-from CUB-Réa Network. Crit Care. 2019 Apr 25; 23(1):143.
Hariri G, Joffre J, Leblanc G, Bonsey M, Lavillegrand JR, Urbina T, Guidet B, Maury E, Bakker J, Ait-Oufella H. Narrative review: clinical assessment of peripheral tissue perfusion in septic shock. Ann Intensive Care. 2019 Mar 13; 9(1):37.
Baudel JL, Dubee V, Boelle PY, Bourcier S, Leblanc G, Joffre J, Bigé N, Preda G, Dumas G, Guidet B, Maury E, Ait-Oufella H. The Weaning Index combining EtCO2 and respiratory rate early identifies Spontaneous Breathing Trial failure. Minerva Anestesiol. 2019 04; 85(4):384-392.
Urbina T, Bigé N, Nguyen Y, Boelle PY, Dubée V, Joffre J, Abdallah I, Baudel JL, Maury E, Guidet B, Ait-Oufella H. Tissue perfusion alterations correlate with mortality in patients admitted to the intensive care unit for acute pulmonary embolism: An observational study. Medicine (Baltimore). 2018 Oct; 97(42):e11993.
Joffre J, Bourcier S, Hariri G, Miailhe AF, Bigé N, Dumas G, Dubée V, Boelle PY, Abdallah I, Baudel JL, Guidet B, Maury E, Ait-Oufella H. Reversible Microvascular Hyporeactivity to Acetylcholine During Diabetic Ketoacidosis. Crit Care Med. 2018 08; 46(8):e772-e778.
Pariente A, Joffre J, Fain O, Coppo P, Mekinian A. Plasma Exchanges for Refractory Evans Syndrome. Ther Apher Dial. 2018 10; 22(5):560-562.
Hariri G, Baudel JL, Dubee V, Dumas G, Joffre J, Bourcier S, Bige N, Ait Oufella H, Maury E. Nasotracheal intubation in ICU: an unfairly forgotten procedure. Minerva Anestesiol. 2018 08; 84(8):997-998.
Hariri G, Joffre J, Deryckere S, Bigé N, Dumas G, Baudel JL, Maury E, Guidet B, Ait-Oufella H. Albumin infusion improves endothelial function in septic shock patients: a pilot study. Intensive Care Med. 2018 05; 44(5):669-671.
Zeboudj L, Maître M, Guyonnet L, Laurans L, Joffre J, Lemarie J, Bourcier S, Nour-Eldine W, Guérin C, Friard J, Wakkach A, Fabre E, Tedgui A, Mallat Z, Tharaux PL, Ait-Oufella H. Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis. J Am Coll Cardiol. 2018 01 16; 71(2):160-172.
Nour-Eldine W, Joffre J, Zibara K, Esposito B, Giraud A, Zeboudj L, Vilar J, Terada M, Bruneval P, Vivier E, Ait-Oufella H, Mallat Z, Ugolini S, Tedgui A. Genetic Depletion or Hyperresponsiveness of Natural Killer Cells Do Not Affect Atherosclerosis Development. Circ Res. 2018 01 05; 122(1):47-57.
Joffre J, Ait-Oufella H. Targeting the immune response in atherosclerosis: It's time for clinical trials! Arch Cardiovasc Dis. 2017 Dec; 110(12):643-645.
Moraly J, Dahoumane R, Dubée V, Preda G, Baudel JL, Joffre J, Bigé N, Ait-Oufella H, Maury E. Penicillin G susceptibility in Staphylococcus aureus is not so infrequent. Minerva Anestesiol. 2018 01; 84(1):123-124.
Giraud A, Zeboudj L, Vandestienne M, Joffre J, Esposito B, Potteaux S, Vilar J, Cabuzu D, Kluwe J, Seguier S, Tedgui A, Mallat Z, Lafont A, Ait-Oufella H. Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production. Cardiovasc Res. 2017 Sep 01; 113(11):1364-1375.
Ponnuswamy P, Joffre J, Herbin O, Esposito B, Laurans L, Binder CJ, Tedder TF, Zeboudj L, Loyer X, Giraud A, Zhang Y, Tedgui A, Mallat Z, Ait-Oufella H. Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. Sci Rep. 2017 06 23; 7(1):4111.
Bourcier S, Joffre J, Dubée V, Preda G, Baudel JL, Bigé N, Leblanc G, Levy BI, Guidet B, Maury E, Ait-Oufella H. Marked regional endothelial dysfunction in mottled skin area in patients with severe infections. Crit Care. 2017 Jun 23; 21(1):155.
Preda G, Bigé N, Bonsey M, Joffre J, Ait-Oufella H, Maury E, Vezzani A, Manca T, Brusasco C, Santori G, Cantadori L, Ramelli A, Gonzi G, Nicolini F, Gherli T, Corradi F. Discussion on "A randomized clinical trial of ultrasound-guided infra-clavicular cannulation of the subclavian vein in cardiac surgical patients: short-axis versus long-axis approach". Intensive Care Med. 2017 08; 43(8):1169-1170.
Joffre J, Preda G, Arrivé L, Maury E. Fatal Aortic Dissection during Extracorporeal Membrane Oxygenation Axillary Cannulation Confirmed by Postmortem Computed Tomography Angiography. Am J Respir Crit Care Med. 2017 Apr 01; 195(7):953-954.
Preda G, Bourcier S, Joffre J, Boelle PY, Dubee V, Baudel JL, Bige N, Guidet B, Maury E, Ait-Oufella H. Mottling score is associated with 28-day mortality in critically ill patients with sepsis. Minerva Anestesiol. 2017 06; 83(6):664-666.
Joffre J, Potteaux S, Zeboudj L, Loyer X, Boufenzer A, Laurans L, Esposito B, Vandestienne M, de Jager SC, Hénique C, Zlatanova I, Taleb S, Bruneval P, Tedgui A, Mallat Z, Gibot S, Ait-Oufella H. Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis. J Am Coll Cardiol. 2016 Dec 27; 68(25):2776-2793.
Bigé N, Dubée V, Alves M, Pichereau C, Bourcier S, Joffre J, Preda G, Baudel JL, Galbois A, Ait-Oufella H, Maury E. Use of a needle-guided device to facilitate axillary vein cannulation. Minerva Anestesiol. 2017 01; 83(1):102-103.
Joffre J, Hau E, Zeboudj L, Laurans L, Battistella M, Boufenzer A, Masson A, Le Buanec H, Cochaud S, Bagot M, Bensussan A, Gibot S, Bouaziz JD, Ait-Oufella H. Trem-1 is not crucial in psoriasiform imiquimod-induced skin inflammation in mice. Exp Dermatol. 2016 05; 25(5):400-2.
Gouffran G, Rosencher J, Bougouin W, Jakamy R, Joffre J, Lamhaut L, Dumas F, Cariou A, Varenne O. Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: Are the new P2Y12 inhibitors really more effective than clopidogrel? Resuscitation. 2016 Jan; 98:73-8.
Parienti JJ, Mongardon N, Mégarbane B, Mira JP, Kalfon P, Gros A, Marqué S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D, 3SITES Study Group . Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med. 2015 Sep 24; 373(13):1220-9.
Joffre J, Ait-Oufella H, Mallat Z. [Role of inflammation in coronary artery disease]. Rev Prat. 2015 Mar; 65(3):324-5.
Arangalage D, Ederhy S, Dufour L, Joffre J, Van der Vynckt C, Lang S, Tzourio C, Cohen A. Relationship between cognitive impairment and echocardiographic parameters: a review. J Am Soc Echocardiogr. 2015 Mar; 28(3):264-74.
Zannis K, Joffre J, Czitrom D, Folliguet T, Noghin M, Lansac MN, Mitchell-Heggs L, Debauchez M, Laborde F. Aortic valve replacement with the perceval S bioprosthesis: single-center experience in 143 patients. J Heart Valve Dis. 2014 Nov; 23(6):795-802.
Joffre J, Varenne O, Bougouin W, Rosencher J, Mira JP, Cariou A. Stent thrombosis: an increased adverse event after angioplasty following resuscitated cardiac arrest. Resuscitation. 2014 Jun; 85(6):769-73.
Ait-Oufella H, Wang Y, Herbin O, Bourcier S, Potteaux S, Joffre J, Loyer X, Ponnuswamy P, Esposito B, Dalloz M, Laurans L, Tedgui A, Mallat Z. Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice. Arterioscler Thromb Vasc Biol. 2013 Oct; 33(10):2374-9.
Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payré C, Yamamoto K, Binder CJ, Murakami M, Tedgui A, Lambeau G, Mallat Z. Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):466-73.
Ait-Oufella H, Joffre J, Boelle PY, Galbois A, Bourcier S, Baudel JL, Margetis D, Alves M, Offenstadt G, Guidet B, Maury E. Knee area tissue oxygen saturation is predictive of 14-day mortality in septic shock. Intensive Care Med. 2012 Jun; 38(6):976-83.
Ait-Oufella H, Lemoinne S, Boelle PY, Galbois A, Baudel JL, Lemant J, Joffre J, Margetis D, Guidet B, Maury E, Offenstadt G. Mottling score predicts survival in septic shock. Intensive Care Med. 2011 May; 37(5):801-7.
Lepillier A, Chaib A, Bougouin W, Joffre J, Durand E, Salvi S, Bruneval P, Danchin N. [Case report and review of a voluminous right atrial myxoma revealed by heart failure]. Ann Cardiol Angeiol (Paris). 2010 Feb; 59(1):37-9.