Prasad Shirvalkar, MD, PhD

Assoc Professor in Residence
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Publications: 
Staudt MD, Yaghi NK, Mazur-Hart DJ, Shirvalkar P. Editorial: Advancements in deep brain stimulation for chronic pain control. Front Pain Res (Lausanne). 2023; 4:1293919.
Kwong J, Lin J, Leriche R, Wozny TA, Shaughnessy A, Schmitgen A, Shirvalkar P. Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams. J Vis Exp. 2023 07 07; (197).
Motzkin JC, Kanungo I, D'Esposito M, Shirvalkar P. Network targets for therapeutic brain stimulation: towards personalized therapy for pain. Front Pain Res (Lausanne). 2023; 4:1156108.
Chad Sitgraves, Prasad Shirvalkar, Lawrence Poree. ID: 221565 EEG Signatures of Epidural Spinal Cord Stimulation: A Dosing and Mechanism of Action Study. Neuromodulation Technology at the Neural Interface. 2023 Jun 1; 26(4):s43.
Shirvalkar P, Prosky J, Chin G, Ahmadipour P, Sani OG, Desai M, Schmitgen A, Dawes H, Shanechi MM, Starr PA, Chang EF. First-in-human prediction of chronic pain state using intracranial neural biomarkers. Nat Neurosci. 2023 06; 26(6):1090-1099.
Shirvalkar P, Poree L. How SAFE Is Real-world Use of Spinal Cord Stimulation Therapy for Chronic Pain? JAMA Neurol. 2023 01 01; 80(1):10-11.
Wong JK, Deuschl G, Wolke R, Bergman H, Muthuraman M, Groppa S, Sheth SA, Bronte-Stewart HM, Wilkins KB, Petrucci MN, Lambert E, Kehnemouyi Y, Starr PA, Little S, Anso J, Gilron R, Poree L, Kalamangalam GP, Worrell GA, Miller KJ, Schiff ND, Butson CR, Henderson JM, Judy JW, Ramirez-Zamora A, Foote KD, Silburn PA, Li L, Oyama G, Kamo H, Sekimoto S, Hattori N, Giordano JJ, DiEuliis D, Shook JR, Doughtery DD, Widge AS, Mayberg HS, Cha J, Choi K, Heisig S, Obatusin M, Opri E, Kaufman SB, Shirvalkar P, Rozell CJ, Alagapan S, Raike RS, Bokil H, Green D, Okun MS. Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury. Front Hum Neurosci. 2022; 16:813387.
Prosky J, Cagle J, Sellers KK, Gilron R, de Hemptinne C, Schmitgen A, Starr PA, Chang EF, Shirvalkar P. Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain. Front Neurosci. 2021; 15:762097.
Burke JF, Kunwar N, Yaroshinsky MS, Louie KH, Shirvalkar P, Su P, Henry M, Pasvankas G, Poree L, Jacques L, Wang DD. Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants. Front Hum Neurosci. 2021; 15:721076.
Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:765150.
Amirdelfan K, Hong M, Tay B, Reddy S, Reddy V, Yang M, Khanna K, Shirvalkar P, Abrecht C, Gulati A. High-Frequency Impulse Therapy for Treatment of Chronic Back Pain: A Multicenter Randomized Controlled Pilot Study. J Pain Res. 2021; 14:2991-2999.
Sellers KK, Gilron R, Anso J, Louie KH, Shirvalkar PR, Chang EF, Little SJ, Starr PA. Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System. Front Hum Neurosci. 2021; 15:714256.
Po-Yi Paul Su, Shikha Sharma, Prasad Shirvalkar, Lawrence Poree. Emerging Therapies for the Treatment of Complex Regional Pain Syndrome. . 2021 Jul 3; 213-227.
Schmitgen A, Saal J, Sankaran N, Desai M, Joseph I, Starr P, Chang EF, Shirvalkar P. Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts. Front Neurol. 2021; 12:669172.
Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:644593.
Eshraghi Y, Chakravarthy K, Strand NH, Shirvalkar P, Schuster NM, Abdallah RT, Vallejo R, Sayed D, Kim D, Kim C, Meacham K, Deer T, Translational Research Committee American Society of Pain and Neuroscience (ASPN). The American Society of Pain and Neuroscience (ASPN) Practical Guidelines to Study Design and Scientific Manuscript Preparation in Neuromodulation. J Pain Res. 2021; 14:1027-1041.
Westin Tom, Thoha Pham, Prasad Shirvalkar. A Tale of Two Cords: Diastematomyelia. Pain Medicine. 2021 Feb 4.
Shirvalkar P, Sellers KK, Schmitgen A, Prosky J, Joseph I, Starr PA, Chang EF. A Deep Brain Stimulation Trial Period for Treating Chronic Pain. J Clin Med. 2020 Sep 29; 9(10).
Sayed D, Chakravarthy K, Amirdelfan K, Kalia H, Meacham K, Shirvalkar P, Falowski S, Petersen E, Hagedorn JM, Pope J, Leever J, ASPN MRI Compatibility Working Group, Deer T. A Comprehensive Practice Guideline for Magnetic Resonance Imaging Compatibility in Implanted Neuromodulation Devices. Neuromodulation. 2020 Oct; 23(7):893-911.
Gregory Chin, Heather Dawes, Edward Chang, Prasad Shirvalkar. Cognitive Effects of Limbic Deep Brain Stimulation in Patients with Refractory Chronic Neuropathic Pain (1990). Neurology. 2020 Apr 14; 94(15_supplement).
Prasad Shirvalkar, Gregory Chin, Heather Dawes, Philip Starr, Edward Chang. Decoding Acute and Chronic Pain State from Ambulatory Intracranial Recordings: Towards Closed-Loop Brain Stimulation (233). Neurology. 2020 Apr 14; 94(15_supplement).
Leung A, Shirvalkar P, Chen R, Kuluva J, Vaninetti M, Bermudes R, Poree L, Wassermann EM, Kopell B, Levy R, and the Expert Consensus Panel. Transcranial Magnetic Stimulation for Pain, Headache, and Comorbid Depression: INS-NANS Expert Consensus Panel Review and Recommendation. Neuromodulation. 2020 Apr; 23(3):267-290.
eter Brown, Aik-Choon Tan, Mohamed A El-Esawi, Thomas Liehr, Oliver Blanck, Douglas P Gladue, Gabriel M F Almeida, Tomislav Cernava, Carlos O Sorzano, Andy W K Yeung, Michael S Engel, Arun Richard Chandrasekaran, Thilo Muth, Martin S Staege, Swapna V Daulatabad, Darius Widera, Junpeng Zhang, Adrian Meule, Ken Honjo, Olivier Pourret, Cong-Cong Yin, Zhongheng Zhang, Marco Cascella, Willy A Flegel, Carl S Goodyear, Mark J van Raaij, Zuzanna Bukowy-Bieryllo, Luca G Campana, Nicholas A Kurniawan, David Lalaouna, Felix J Hüttner, Brooke A Ammerman, Felix Ehret, Paul A Cobine, Ene-Choo Tan, Hyemin Han, Wenfeng Xia, Christopher McCrum, Ruud P M Dings, Francesco Marinello, Henrik Nilsson, Brett Nixon, Konstantinos Voskarides, Long Yang, Vincent D Costa, Johan Bengtsson-Palme, William Bradshaw, Dominik G Grimm, Nitin Kumar, Elvis Martis, Daniel Prieto, Sandeep C Sabnis, Said E D R Amer, Alan W C Liew, Paul Perco, Farid Rahimi, Giuseppe Riva, Chongxing Zhang, Hari P Devkota, Koichi Ogami, Zarrin Basharat, Walter Fierz, Robert Siebers, Kok-Hian Tan, Karen A Boehme, Peter Brenneisen, James A L Brown, Brian P Dalrymple, David J Harvey, Grace Ng, Sebastiaan Werten, Mark Bleackley, Zhanwu Dai, Raman Dhariwal, Yael Gelfer, Marcus D Hartmann, Pawel Miotla, Radu Tamaian, Pragashnie Govender, Oliver J Gurney-Champion, Joonas H Kauppila, Xiaolei Zhang, Natalia Echeverría, Santhilal Subhash, Hannes Sallmon, Marco Tofani, Taeok Bae, Oliver Bosch, Páraic O Cuív, Antoine Danchin, Barthelemy Diouf, Tuomas Eerola, Evangelos Evangelou, Fabian V Filipp, Hannes Klump, Lukasz Kurgan, Simon S Smith, Olivier Terrier, Neil Tuttle, David B Ascher, Sarath C Janga, Leon N Schulte, Daniel Becker, Christopher Browngardt, Stephen J Bush, Guillaume Gaullier, Kazuki Ide, Clement Meseko, Gijsbert D A Werner, Jan Zaucha, Abd A Al-Farha, Noah F Greenwald, Segun I Popoola, Shaifur Rahman, Jialin Xu, Sunny Y Yang, Noboru Hiroi, Ozgul M Alper, Chris I Baker, Michael Bitzer, George Chacko, Birgit Debrabant, Ray Dixon, Evelyne Forano, Matthew Gilliham, Sarah Kelly, Karl-Heinz Klempnauer, Brett A Lidbury, Michael Z Lin, Iseult Lynch, Wujun Ma, Edward W Maibach, Diane E Mather, Kutty S Nandakumar, Robert S Ohgami, Piero Parchi, Patrizio Tressoldi, Yu Xue, Charles Armitage, Pierre Barraud, Stella Chatzitheochari, Luis P Coelho, Jiajie Diao, Andrew C Doxey, Angélique Gobet, Pingzhao Hu, Stefan Kaiser, Kate M Mitchell, Mohamed F Salama, Ivan G Shabalin, Haijun Song, Dejan Stevanovic, Ali Yadollahpour, Erliang Zeng, Katharina Zinke, C G Alimba, Tariku J Beyene, Zehong Cao, Sherwin S Chan, Michael Gatchell, Andreas Kleppe, Marcin Piotrowski, Gonzalo Torga, Adugna A Woldesemayat, Mehmet I Cosacak, Scott Haston, Stephanie A Ross, Richard Williams, Alvin Wong, Matthew K Abramowitz, Andem Effiong, Senhong Lee, Muhammad Bilal Abid, Cyrus Agarabi, Cedric Alaux, Dirk R Albrecht, Gerald J Atkins, Charles R Beck, A M J J Bonvin, Emer Bourke, Thomas Brand, Ralf J Braun, James A Bull, Pedro Cardoso, Dee Carter, Robin M Delahay, Bernard Ducommun, Pascal H G Duijf, Trevor Epp, Eeva-Liisa Eskelinen, Mazyar Fallah, Debora B Farber, Jose Fernandez-Triana, Frank Feyerabend, Tullio Florio, Michael Friebe, Saori Furuta, Mads Gabrielsen, Jens Gruber, Malgorzata Grybos, Qian Han, Michael Heinrich, Heikki Helanterä, Michael Huber, Albert Jeltsch, Fan Jiang, Claire Josse, Giuseppe Jurman, Haruyuki Kamiya, Kim de Keersmaecker, Erik Kristiansson, Frank-Erik de Leeuw, Jiuyong Li, Shide Liang, Jose A Lopez-Escamez, Francisco J Lopez-Ruiz, Kevin J Marchbank, Rolf Marschalek, Carmen S Martín, Adriana E Miele, Xavier Montagutelli, Esteban Morcillo, Rosario Nicoletti, Monika Niehof, Ronan O’Toole, Toshihiko Ohtomo, Henrik Oster, Jose-Alberto Palma, Russell Paterson, Mark Peifer, Maribel Portilla, M C Portillo, Antonia L Pritchard, Stefan Pusch, Gajendra P S Raghava, Nicola J Roberts, Kehinde Ross, Birgitt Schuele, .... Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database. 2019 Oct 29; 2019.
Shirvalkar P, Veuthey TL, Dawes HE, Chang EF. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain. Front Comput Neurosci. 2018; 12:18.
Prasad Shirvalkar, Lawrence R. Poree, Elliot S. Krames. Chapter 47 The Development of Algorithms for Pain Care Including Neuromodulation Therapies Introducing the SAFE Principles. Neuromodulation. 2018 Jan 1; 609-616.
Al-Kaisy Adnan, Andreas Alexopoulos, Kenneth M. Alo, Ron L. Alterman, Arun Amar, Pablo Andrade, Sailesh Arulkumar, Ahmed J. Awad, Gordon Baltuch, Giancarlo Barolat, Ernest J. Barthélemy, Neil U. Barua, Maria E. Bennett, Nicole Bentley, Yarema B. Bezchlibnyk, Kelly R. Bijanki, William Bingaman, Joseph W. Boggs, Paul Boon, Brigitte A. Brouwer, Lucas W. Campos, Anthony Caparso, Annamaria Capozzo, John Chae, Jin Woo Chang, Jennifer Cheng, David Copenhaver, Timothy R. Deer, Milind Deogaonkar, Deepali Dhar, Keeley Dohmeier, Darin D. Dougherty, Dominique M. Durand, Kelly Foote, Jeffrey Gilligan, Steven S. Gill, Jorge Gonzalez-Martinez, Benjamin D. Greenberg, Robert E. Gross, Michael H. Pourfar, Clement Hamani, Salim M. Hayek, Paul E. Holtzheimer, Brian M. Ilfeld, Haiyan Jin, Bert Joosten, Na Young Jung, Chong H. Kim, Young Goo Kim, Martin Klehr, Paul Koch, Sina Kohl, Brian H. Kopell, Daniel Kramer, Elliot S. Krames, Balu Krishnan, Vibhor Krishna, Jens Kuhn, Jason Kyung-soo Hong, Kapural Leonardo, Michael S. Leong, Dianyou Li, Andreas A. Linninger, Nir Lipsman, Charles Liu, Andres M. Lozano, Michael Mackow, Mark N. Malinowski, Helen S. Mayberg, Paolo Mazzone, Ankit I. Mehta, Vivek Mehta, Reversa Mills-Joseph, Dileep Nair, Richard B. North, Michael Okun, Nikunj K. Patel, Parag G. Patil, Jason E. Pope, Lawrence R. Poree, Joshua P. Prager, Robrecht Raedt, Jonathan J. Rasouli, Serge Rasskazoff, Richard Rauck, Kevin Reeves, Ali R. Rezai, Jonathan Russin, Abraham Sabersky, Michael Saulino, Eugenio Scarnati, Stefan Schu, Mayur Sharma, Jane Shipley, Prasad Shirvalkar, Konstantin V. Slavin, Michael Stanton-Hicks, Scellig Stone, William A. Stuart, Bomin Sun, Kevin Tangen, Stewart J. Tepper, Maarten van Kleef, Tim Vancamp, Paul Verrills, Fabio Viselli, Veerle Visser-Vandewalle, Flora Vitale, Kristl Vonck, Tao Wang, Xuelian Wang, Richard L. Weiner, Alik S. Widge, Amorn Wongsarnpigoon, Alon Y. Mogilner, Kurt A. Yaeger, Tony L. Yaksh, Dali Yin, Kristina Zeljic, Chencheng Zhang, Shikun Zhan. List of Contributors of Volume 2. Neuromodulation. 2018 Jan 1; xi-xiii.
M. Cortes, G. Thickbroom, J. Valls-Sole, P. Shirvalkar, A. Pascual-Leone, D. Edwards. Improving lower limb strength in incomplete spinal cord injury with non-invasive spinal associative stimulation. Brain Stimulation. 2017 Mar 1; 10(2):538-539.
Thomas Tropea, Prasad Shirvalkar, Krithiga Sekar, Kyung-Wha Kim, Apostolos Tsiouris, Ehud Lavi, Alan Segal. Amyloid-Beta Related Angitiis and Reversible Cerebral Vasoconstriction Syndrome: A Case Report (P6.057). Neurology. 2016 Apr 5; 86(16_supplement).
Arthie Jeyakumar, Pravin Khemani, Ralph Jozefowicz, Prasad Shirvalkar, Augusto Miravalle, Constantine Farmakidis. Conference Curriculum Content and Organization in United States Neurology Residencies: A Cross-Sectional Survey (P2.354). Neurology. 2016 Apr 5; 86(16_supplement).
Wang E, Shirvalkar PR, Maciel CB, Merkler AE, Safdieh J, Gupta A. American neuroborreliosis presenting as cranial polyneuritis and radiculoneuritis. Neurol Neuroimmunol Neuroinflamm. 2014 Oct; 1(3):e30.
Carolina Maciel, Erwin Wang, Prasad Shirvalkar, Alexander Merkler, Joseph Safdieh. Widespread Leptomeningeal Involvement in Borreliosis (P2.317). Neurology. 2014 Apr 8; 82(10_supplement).
Bahar AS, Shirvalkar PR, Shapiro ML. Memory-guided learning: CA1 and CA3 neuronal ensembles differentially encode the commonalities and differences between situations. J Neurosci. 2011 Aug 24; 31(34):12270-81.
Ferbinteanu J, Shirvalkar P, Shapiro ML. Memory modulates journey-dependent coding in the rat hippocampus. J Neurosci. 2011 Jun 22; 31(25):9135-46.
Prasad R. Shirvalkar, Mathew L. Shapiro. Design and Construction of a Cost Effective Headstage for Simultaneous Neural Stimulation and Recording in the Water Maze. Journal of Visualized Experiments. 2010 Oct 13; (44).
Shirvalkar PR, Shapiro ML. Design and construction of a cost effective headstage for simultaneous neural stimulation and recording in the water maze. J Vis Exp. 2010 Oct 13; (44).
Tejas R. Shah, Angeliki Vouyouka, Daniel K. Han, Sharif Ellozy, Robert Lookstein, Prasad Shirvalkar, Michael Marin, Peter L. Faries. Infrageniculate Interventions in Female Patients: Improved Patency Rates but Higher Rates of Postoperative Complications. Journal of Vascular Surgery. 2010 Apr 1; 51(4):1070-1071.
Shirvalkar PR, Rapp PR, Shapiro ML. Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):7054-9.
Shirvalkar P, Bahar AS. The multiple origins and laminar topography of the hippocampal theta rhythm. J Neurosci. 2009 Jun 03; 29(22):7111-3.
Shirvalkar PR. Hippocampal neural assemblies and conscious remembering. J Neurophysiol. 2009 May; 101(5):2197-200.
Shirvalkar P, Seth M, Schiff ND, Herrera DG. Cognitive enhancement with central thalamic electrical stimulation. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):17007-12.
Evelyn Kim, Prasad Shirvalkar, Daniel G. Herrera. Regulation of neurogenesis in the aging vertebrate brain: role of oxidative stress and neuropsychiatric factors. Clinical Neuroscience Research. 2003 Jan 1; 2(5-6):285-293.
Honors and Awards: 
LRP, National Institutes of Health, 2019-2021
Catalyst Innovation Award, UCSF, 2019-2020
Best Scientific Abstract, International Neuromodulation Society, 2019
Exceptional Clinician Award - Hon Mention, UCSF, 2018
Outstanding Neurology Teaching Award, Weill Cornell Medicine, 2016