Xiaobing Yu, MD

Associate Professor of Anesthesia
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Biography: 

Dr. Xiaobing Yu is an anesthesiologist who collaborates with a health care team to improve quality of life and manage pain for patients with a wide array of chronic pain conditions. He provides innovative interventional procedures guided by ultrasound or fluoroscopy (an imaging technique using continuous X-rays) to treat many chronic and persistent pain conditions. These include mouth or face pain (such as trigeminal neuralgia), failed back surgery syndrome, facetogenic pain (involving the facet joints of the spine's vertebrae), neuropathic pain, complex regional pain syndrome and pain associated with cancer.

Yu's research explores new treatments for neuropathic pain, with the goal of improving the standard of care for this chronic condition.

After earning his medical degree at Peking Union Medical College, Yu completed a residency in anesthesiology at Brigham and Women's Hospital, an affiliate of Harvard Medical School. He completed a fellowship in pain medicine at UCSF before joining the faculty.

Yu belongs to the American Society of Anesthesiologists, California Society of Anesthesiologists, American Society of Regional Anesthesia and Pain Medicine, and International Association for the Study of Pain.

Yu has a strong commitment to medical education. He directs the chronic pain rotation for UCSF residents as well as a specialty training course in pain management.

Publications: 
Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC. ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. Pain. 2023 01 01; 164(1):43-58.
Yu X, Basbaum A, Guan Z. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain Rep. 2021; 6(1):e883.
Khan F, Yu X, Hsiao EC. Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva. Biomedicines. 2021 Feb 05; 9(2).
Sharma S, Ly W, Yu X. Maxillary Nerve-Mediated Postseptoplasty Nasal Allodynia: A Case Report. A A Pract. 2020 Nov; 14(13):e01356.
Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020 01 14; 11(1):264.
Yu X, Leff J, Guan Z. Rapid Isolation of Dorsal Root Ganglion Macrophages. J Vis Exp. 2019 09 07; (151).
Peniche A, Poree L, Schumacher M, Yu X. Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. A A Pract. 2018 Jun 01; 10(11):285-287.
Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012 Oct 26; 287(44):36720-31.
Jia Y, Warin R, Yu X, Epstein R, Noguchi CT. Erythropoietin signaling promotes transplanted progenitor cell survival. FASEB J. 2009 Sep; 23(9):3089-99.
Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L. Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Cell Stem Cell. 2008 May 08; 2(5):461-71.
Alder JK, Georgantas RW, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI. Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J Immunol. 2008 Apr 15; 180(8):5645-52.
Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT. Hypoxia alters progression of the erythroid program. Exp Hematol. 2008 Jan; 36(1):17-27.
Shen TJ, Rogers H, Yu X, Lin F, Noguchi CT, Ho C. Modification of globin gene expression by RNA targeting strategies. Exp Hematol. 2007 Aug; 35(8):1209-18.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet. 2007 Feb; 39(2):237-42.
Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI. HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells. 2006 Apr; 24(4):876-88.
Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT. Tal1/SCL binding to pericentromeric DNA represses transcription. J Biol Chem. 2005 Apr 01; 280(13):12956-66.
Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development. 2004 Sep; 131(17):4213-24.
Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood. 2004 Oct 01; 104(7):2073-80.
Dunlap S, Yu X, Cheng L, Civin CI, Alani RM. High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. J Invest Dermatol. 2004 Feb; 122(2):549-51.
Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38.
Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT. Erythropoietin receptor signalling is required for normal brain development. Development. 2002 Jan; 129(2):505-16.
Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N. Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Blood Cells Mol Dis. 2001 Nov-Dec; 27(6):971-7.
Yu X, Lin CS, Costantini F, Noguchi CT. The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. Blood. 2001 Jul 15; 98(2):475-7.
Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT. Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. J Biol Chem. 2000 Dec 15; 275(50):39754-61.
Chin K, Yu X, Beleslin-Cokic B, Liu C, Shen K, Mohrenweiser HW, Noguchi CT. Production and processing of erythropoietin receptor transcripts in brain. Brain Res Mol Brain Res. 2000 Sep 30; 81(1-2):29-42.