Arthur Wallace, MD, PhD

Professor Emeritus
Vice-Chair SFVAMC
SFVAMC Chief of Anesthesia
Research Lab Director, Cardiac Engineering Lab
[email protected]
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Biography: 

Art Wallace, M.D., Ph.D. is a professor and vice-chair of anesthesiology and perioperative care at the University of California, San Francisco and Chief of the Anesthesia Service at the Veterans Affairs Medical Center in San Francisco. His clinical practice includes cardiac and non-cardiac anesthesiology as well as ICU and preoperative clinical care. He completed a B.S. in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including device development for monitoring, surgical therapy of heart failure, and the off pump CABG, as well as drug development and testing. He is best known for his work developing medications for the prevention of perioperative cardiac morbidity and mortality. He was one of the developers of perioperative beta blockade and has assisted more than 200 hospitals set up perioperative beta blocker programs. His present work includes development medications to reduce perioperative cardiac risk, development of the ECOM cardiac output monitor, developing a non-invasive respiratory monitor, a device to provide electronic sedation, testing and development of surgical therapies for heart failure, implementation of perioperative beta blockade, developing therapies to prevent perioperative and ICU related PTSD, and developing computer systems to improve systems based medicine. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction. intelligence.

Publications: 
Wallace AW, Cirillo PM, Ryan JC, Krigbaum NY, Badathala A, Cohn BA. Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study. BMJ Open. 2021 12 31; 11(12):e050051.
Cohn BA, Cirillo PM, Murphy CC, Krigbaum NY, Wallace AW. SARS-CoV-2 vaccine protection and deaths among US veterans during 2021. Science. 2022 01 21; 375(6578):331-336.
Zhang Y, Adams J, Wang VY, Horwitz L, Tartibi M, Morgan AE, Kim J, Wallace AW, Weinsaft JW, Ge L, Ratcliffe MB. A finite element model of the cardiac ventricles with coupled circulation: Biventricular mesh generation with hexahedral elements, airbags and a functional mockup interface to the circulation. Comput Biol Med. 2021 10; 137:104840.
Pennybaker S, Roach BJ, Fryer SL, Badathala A, Wallace AW, Mathalon DH, Marton TF. Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression. Psychopharmacology (Berl). 2021 Nov; 238(11):3229-3237.
Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe MB. A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction. Magn Reson Med. 2021 10; 86(4):2105-2121.
Soncrant C, Neily J, Sum-Ping SJT, Wallace AW, Mariano ER, Leissner KB, Mills PD, Mazzia L, Paull DE. Sharing Lessons Learned to Prevent Adverse Events in Anesthesiology Nationwide. J Patient Saf. 2021 06 01; 17(4):e343-e349.
Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB. Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain. J Mech Behav Biomed Mater. 2021 07; 119:104431.
Brzezinski M, Dincheva GR, Alloo K, Wong C, Feng CM, Tom WL, Salahieh A, Wallace AW. Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow. Drugs R D. 2020 Sep; 20(3):279-290.
Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB. Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep. PLoS One. 2020; 15(6):e0234896.
Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. J Biomed Mater Res A. 2020 08 01; 108(8):1736-1746.
Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW. Freedom From Opioids After Total Knee Arthroplasty. J Arthroplasty. 2019 05; 34(5):893-897.
Varughese S, Kalthod VG, Petzel JP, Bacher HP, Wallace AW. Investigation of possible aqueous phase formation during vaporization of sevoflurane. J Anaesthesiol Clin Pharmacol. 2019 Jan-Mar; 35(1):76-80.
Lee SM, Tenney R, Wallace AW, Arjomandi M. E-cigarettes versus nicotine patches for perioperative smoking cessation: a pilot randomized trial. PeerJ. 2018; 6:e5609.
Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PLoS One. 2018; 13(2):e0192720.
Wallace AW. Sevoflurane Contamination: Water Accumulation in Sevoflurane Vaporizers Can Allow Bacterial Growth in the Vaporizer. A A Case Rep. 2016 Jun 15; 6(12):399-401.
Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016 May; 101(5):1691-9.
Lee SM, Takemoto S, Wallace AW. In Reply. Anesthesiology. 2016 Feb; 124(2):513-4.
Lee SM, Takemoto S, Wallace AW. Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System. Anesthesiology. 2015 Aug; 123(2):288-306.
Mudumbai SC, Wagner T, Mahajan S, King R, Heidenreich PA, Hlatky M, Wallace AW, Mariano ER. Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia. Springerplus. 2014; 3:227.
Mudumbai SC, Takemoto S, Cason BA, Au S, Upadhyay A, Wallace AW. Thirty-day mortality risk associated with the postoperative nonresumption of angiotensin-converting enzyme inhibitors: a retrospective study of the Veterans Affairs Healthcare System. J Hosp Med. 2014 May; 9(5):289-96.
Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Ann Thorac Surg. 2013 May; 95(5):1619-25.
Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB. Left ventricular pressure gating in ovine cardiac studies: a software-based method. J Biomech Eng. 2013 Mar 01; 135(3):34502.
Wallace AW. Risk of acute myocardial infarction in patients with total hip or knee replacement: comment on "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study". Arch Intern Med. 2012 Sep 10; 172(16):1235-6.
Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Front Physiol. 2012; 3:86.
Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM. A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure. Comput Methods Biomech Biomed Engin. 2013; 16(8):807-18.
Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann Thorac Surg. 2012 Mar; 93(3):776-82.
Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20.
Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM. A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction. J Biomech Eng. 2011 Sep; 133(9):094506.
Wallace AW, Au S, Cason BA. Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol. Anesthesiology. 2011 Apr; 114(4):824-36.
Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. J Biomech Eng. 2011 Apr; 133(4):044501.
Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB. Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Ann Thorac Surg. 2011 Jan; 91(1):150-6.
Wallace AW, Au S, Cason BA. Association of the pattern of use of perioperative β-blockade and postoperative mortality. Anesthesiology. 2010 Oct; 113(4):794-805.
Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Ann Thorac Surg. 2010 May; 89(5):1546-53.
Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):233-9, 239.e1-4.
Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. J Biomech Eng. 2009 Nov; 131(11):111001.
Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008 May; 135(5):1094-102, 1102.e1-2.
Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):1017-24.
Wallace AW. Clonidine and modification of perioperative outcome. Curr Opin Anaesthesiol. 2006 Aug; 19(4):411-7.
Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):579-586.e3.
Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005 Oct; 130(4):1032-8.
Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H692-700.
Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):382-90.
Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005 Jan; 79(1):185-93.
Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1844-50.
Wallace AW, Galindez D, Salahieh A, Layug EL, Lazo EA, Haratonik KA, Boisvert DM, Kardatzke D. Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Anesthesiology. 2004 Aug; 101(2):284-93.
Wallace AW. Is it time to get on the fast track or stay on the slow track? Anesthesiology. 2003 Oct; 99(4):774.
Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Ann Thorac Surg. 2003 Oct; 76(4):1171-80; discussion 1180.
Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep-Oct; 48(5):508-13.
Victal OA, Teerlink JR, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB. Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure. Circulation. 2002 Mar 19; 105(11):1317-22.