Faculty Biographies
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M.D. or Ph.D. Institution: University of Vermont, School of Medicine
Internship: Maine Medical Center
Anesthesia Residency: Beth Israel Deaconess Medical Center
Fellowship(s): Stanford University School of Medicine
M.D. or Ph.D. Institution: Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland
Internship: Tripler Army Medical Center: General Surgery
Anesthesia Residency: Walter Reed Army Medical Center
Fellowship(s): Pediatric: Childrens National Medical Center
Dr. Antoine performs her research in All-Hazards Preparedness. This emerging area of interest includes personal perparedness, hospital preparedness, community, regional and national preparedness. Her recent research has been in surge capacity management. She has an ongoing research project in airway devices which could be best utilized in disaster scenarios requiring providers to be in personal protective equipment.
M.D. or Ph.D. Institution: Justus-Liebig-Universitat Giessen, Germany
Anesthesia Residency: Julius Maximilians-Universitat, Wurzburg, Germany
Dr. Apfel is focused on clinical research on a wide range of outcomes, including but not limited to postoperative nausea, vomiting, pain, ventilator associated pneumonia etc. In collaboration with other colleagues he performs evidence based quantitative systematic reviews, epidemiological research and controlled clinical single and multi-center investigator-initiated or registration trials. He joined the faculty in April 2006 and leads the Perioperative Clinical Research Core.
Dr. Bainton explores the relationship between drugs that act on the nervous system and the genetic constituents that make up that system. Specifically, we use forward and reverse genetic screens on Drosophila melanogaster to find genes that change drug-induced behavioral outputs.
M.D. or Ph.D. Institution: Freie Universitaet Berlin, Germany
Anesthesia Residency: Krankenhaus Am Urban, Charite Berlin, Germany
Fellowship(s): Intensive Care Medicine
Dr Baumann's clinical responsibilities will be at San Francisco General Hospital.
Main interests: Critical Care/Trauma/Regional Anesthesia
Director of Trauma Anesthesia, ATLS-Instructor, PHTLS & PALS certified.
Ass. Director of the Regional Anesthesia Rotation
Dr. Behrends studies the inflammatory response evoked by hepatic ischemia and how to alter this response pharmacologically. He also investigates the myocardial effectsof liver disease in collaboration with the Department of Cardiology at UCSF.
M.D. or Ph.D. Institution: University of California at San Diego
Internship: St. Mary's Medical Center, San Francisco
Anesthesia Residency: UCSF
Fellowship(s): UCSD, CVRI (UCSF), Anesthesia (UCSF)
Dr. Bickler is involved in a broad array of studies related to how the brain adapts to an insufficient supply of oxygen. The Bickler Lab studies the adaptations to hypoxia in a wide range of models, including cells in states of suspended animation, in developing neurons from the hippocampus of rats, and in humans at high altitude.
Other studies include efforts to understand how low temperature injures neurons and determining novel means to engineer cold-tolerance. This work aims to improve clinical use of hypothermia in organ protection. The main focus is on potassium channel activity as a key determinant of survival in the cold. Hibernation is a natural model exploited in these studies.
We also investigate the long-term effects of anesthetics, both beneficial and deleterious. Effects of anesthetics on neural stem cells, newly formed neurons, and in aging neurons are all of interest in these efforts.
Medical Director, UCSF Surgery Center
Member, Academy of Medical Educators, UCSF SOM
M.D. or Ph.D. Institution: University of IL, Chicago
Internship: UCSF Internal medicine
Anesthesia Residency: UCSF
Fellowship(s): UCSF: Anesthesia and Trauma
Chief Resident
Home Town: Hyde Park, NY
M.D. or Ph.D. Institution: UCSF
Internship: Massachusetts General Hospital
Anesthesia Residency: University of California, San Francisco
M.D. or Ph.D. Institution: Georg-August-Universitaet Goettingen, Germany
Anesthesia Residency: University Hospital Frankfurt, Germany
Fellowship(s): Pain Medicine, Orthopedic University Hospital Frankfurt, Germany
Dr. Braehler worked as an Attending Anesthesiologist in the Department of Anesthesiology at the Orthopedic University Hospital Frankfurt, Germany, from 2003 until 2006. Among other obligations, he was responsible for the organization of Continuous Medical Education teaching sessions for residents and attendings.
Dr. Braehler's clinical responsibilities will be at Moffitt Long Hospital and Mount Zion Hospital.
Clinical Professor of Pediatrics
M.D. or Ph.D. Institution: University of Miami
Internship: San Francisco General Hospital
Anesthesia Residency: UCSF
Fellowship(s): UCSF
Dr. Brett collaborates with the laboratory of Dr Kathleen Giacomini (Chair of Biopharmaceutical Sciences, UCSF), focusing on the clinical studies in the project, Pharmacogenetics of Membrane Transporters. Membrane transporters are a group of proteins of pharmacological importance because they provide the target for about 30 percent of the most commonly used drugs. The goal of the studies are to identify sequence variants in a large number of transporter genes with known or suspected relevance to pharmacogenetics.
M.D. or Ph.D. Institution: Westfälische Wilhelms-University Münster, Germany
Anesthesia Residency: University of Chicago, Chicago IL
Fellowship(s): Critical Care Medicine, Massachusetts General Hospital, Boston MA; Cardiothoracic Anesthesia, Duke University Medical Center, Durham NC
Dr Brzezinski's clinical practice includes critical care medicine and anesthesia for cardiac and thoracic surgery. His research interests are cardiothoracic anesthesia, intraoperative transesophageal echocardiography and its effects on anesthetic and surgical management. Dr. Brzezinski is also Director for visiting medical students in anesthesia, UCSF course 140.01.
M.D. or Ph.D. Institution: M.D. Harvard Medical School
Internship: Brigham and Woman's Hospital
Anesthesia Residency: UCSF
Fellowship(s): UCSF
M.D. or Ph.D. Institution: Glasgow University, Scotland
Anesthesia Residency: Glasgow Royal Infirmary, Scotland
Dr. Caldwell investigates neuromuscular pharmacology, particularly pharmacokinetics. Dr. Caldwell also is investigating management science and how the principles of management science can be applied to the operating room.
Dr. Campbell does his clinical work and teaching in the operating rooms and the critical care units at both Moffitt and Mount Zion Hospitals.
Associate Dean for UCSF at SFGH
M.D. or Ph.D. Institution: University of Pennsylvania
Internship: UCSF
Anesthesia Residency: UCSF
Fellowship(s): UCSF critical care
Dr. Cason studies management and policy issues of perioperative medicine. A current specific focus is on study of surgical and ICU outcomes through use of large electronic clinical and administrative databases within the Veterans Affairs Health system. In "CALICO", The California Intensive Care Outcomes Project, Dr. Cason serves as the project’s perioperative medicine expert, developing new tools and methods to measure and risk-adjust perioperative ICU outcomes.
MBA
M.D. or Ph.D. Institution: UCSF
Internship: Medicine, California Pacific Medical Center
Anesthesia Residency: UCSF
Fellowship(s): Cardiac Anesthesia & Critical Care, Brigham & Women's Hospital, Harvard University
Dr. Cassorla works in the Moffitt-Long, Mount Zion and Ambulatory Surgery Center operating rooms. She is experienced in anesthesia for thoracic, vascular, and open heart procedures on adults, children, and infants, as well as adult and pediatric transesophageal echocardiography (TEE).
M.D. or Ph.D. Institution: UCSF
Internship: Children's Hospital and Medical Center, Seattle WA
Anesthesia Residency: UCSF/U Penn
Fellowship(s): Children's Hospital of Philadelphia
After graduating from UC Berkeley with a degree in Physics, I completed a PhD in Molecular Biology at UCLA, then did an NIH Postdoctoral Fellowship at UCSD and U Hawaii. I returned to the Bay Area, and taught in a community college until entering medical school at UCSF, graduating in 1981. I then began a pediatrics residency in Seattle, took a year off after two years there and finished in Vancouver, BC. After working in the Children's Hospital in Seattle for a year and a half, I began anesthesia residency at UCSF. After two years, I transferred to Children's Hospital of Philadelphia where I remained for 18 months. I then took a job at UCSF. Three years later I moved to the Children's Hospital of Michigan in Detroit, where I stayed for 5 years, the last three as Chief of the Department. In 1998, I finally returned to UCSF, as Chief of the Division of Pediatric Anesthesia. At the end of March of 2008, I stepped down as Chief.
Other than my involvement with pediatrics, I am also associated with the Fetal Treatment Center, and perform anesthesia for Fetal Surgery.
M.D. or Ph.D. Institution: UCSF
Internship: CPMC
Anesthesia Residency: UCSF
M.D. or Ph.D. Institution: University of Rochester, School of Medicine and Dentistry
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Critical Care Fellowship, University of California, San Francisco
M.D. or Ph.D. Institution: University of North Carolina, Chapel Hill, School of Medicine, Chapel Hill, North Carolina
Anesthesia Residency: University of California, San Francisco
Dr. Claassen works exclusively at San Francisco General Hospital.
Vice Dean
Dr. Cohen teaches and does research in the critical care units in the following areas:
Sedation and Pain Management in Critical Care
Ethical Issues in Critical Care
Death and Dying in Critically Ill Patients
Assessing and Treating Symptoms for Dying ICU Patients
M.D. or Ph.D. Institution: University of Pittsburgh School of Medicine
Anesthesia Residency: University of California, San Francisco
Dr. Collins joined the Department of Anesthesia and Perioperative Care in 2000. He does his clinical work as San Francisco General Hospital, where his main area of clinical interest is Ultrasound-Guided regional anesthesia. He is also actively involved with education at the medical student and post-graduate level. To assist with teaching anesthesia procedures, he produces instructional videos and computer generated animations. He is the associate director of the UCSF Department of Anesthesia and Periopertive Care Center for Healthcare Simulation, located at the San Francisco General Hospital campus, where he directs and instructs a variety of full task medical simulation courses. Dr. Collins is dedicated to the application of technology to clinical care, administration, and education.
Dr. Donegan tries to limit the spread of HIV in Indonesia by trying to decrease the spread of sexually transmitted disease and improving preventive measures.
Dr. Drasner has developed an in vivo model of anesthetic neurotoxicity that is used in conjunction with established cell culture and electrophysiologic techniques to investigate the mechanisms of anesthetic toxicity and the factors that promote or attenuate damage.
Dr. Dubowitz studies the human physiological response to low oxygen environments. This work is done at UCSF and University of California White Mountain Research Station at 14,246 feet near Bishop California.
Dr Dubowitz is currently investigating acclimatization to hypoxic environments, sleep at altitude, cardiovascular changes observed using echocardiography and new methods of hypoxic ventilatory response testing. Dr Dubowitz also has an active interest in Global Health issues, especially those related to anesthesia and peri-operative care in the developing world. He is currently involved in a number of projects involving global health issues, workforce and burden of surgical disease, especially in sub saharan Africa. He is a founder of the UCSF based "Global Partners in Anesthesia and Surgery" and directs international electives for anesthesia residents in their senior year at UCSF.
Home Town: University of Illinois, Urbana, IL
M.D. or Ph.D. Institution: Northwestern University, Chicago, IL
Internship: St. Luke's Hospital, Chicago IL
Anesthesia Residency: University of Iowa, Iowa City, Iowa
Fellowship(s): University of California, San Francisco, CA
Dr. Eger graduated from the University of Illinois (Phi Beta Kappa, Phi Kappa Phi, Bronze Tablet) and Northwestern University Medical School, interned at St. Lukes Hospital (Chicago), and completed his residency in anesthesia at the University of Iowa under 2 of his heroes, Stuart C. Cullen, MD, and William K. Hamilton, MD.
In 1960, after 2 years in the service of his country at Ft. Leavenworth, Kansas, he followed Dr. Cullen to the University of California, San Francisco, where he is currently a Professor in the Departments of Anesthesia and Perioperative Care, to train with a third hero, John W. Severinghaus, MD. While Dr. Eger completed a 5-year NIH Career Research Development Award fellowship, Dr. Severinghaus provided him with most of his ideas, including the term "MAC" or minimum alveolar concentration, and the basic concepts of anesthetic uptake and distribution.
Dr. Eger has been honored by receiving the American Society of Anesthesiologists Award for Excellence in Research and the American Society of Anesthesiologists Distinguished Service Award. He has published more than 500 peer-reviewed articles. He is a Fellow of the Royal College of Anaesthetists of England and Ireland.
His wonderful wife, Lynn Spitler, MD, promises to keep him off the streets. He has an inordinate (but justified) pride in his 4 children, 2 stepchildren, and innumerable grandchildren. He has an affection for poetry that he may recite, with or without an invitation.
He does not remember having been president of any society.
Dr. Eger is currently the Director of a Program Project Grant in its 14 year entitled "Sites and Mechanisms of Inhaled Anesthetic Action". This project uses genetically engineered animals to define the sites and mechanisms by which inhaled anesthetics exert their effects. In particular, mice mutant for specific neurotransmitter receptor subunits are tested for changes from wild-type controls in their anesthetic requirement, particularly for changes in the concentrations of inhaled anesthetics that produce immobility and amnesia. It also uses specific receptor agonists and antagonists given intravenously and intrathecally to determine the relevance of specific receptors as mediators of the capacity of inhaled anesthetics to produce immobility.
M.D. or Ph.D. Institution: Rheinische Friedrich-Wilhelms-Universitaet, Bonn, Germany
Internship: Boise VA Medical Center, Boise, Idaho
Anesthesia Residency: University Hospital, University of Cologne, Germany, and UCSF
Research:
Dr Eilers is involved in a number of research projects focused on the advancement of our understanding of the molecular mechanisms responsible for the transduction of painful stimuli in peripheral nociceptive neurons. His main effort is currently directed at investigating the effects of general anesthetics in peripheral nociceptors. Irritant anesthetics such as isoflurane have been shown to activate sensory neurons and may contribute to the severity of postoperative pain.
Clinical:
Dr Eilers attends as anesthesiologist in the Moffitt-Long and Mt. Zion operating rooms specializing on anesthesia for liver transplantation.
M.D. or Ph.D. Institution: UCSD School of Medicine
Internship: Internal Medicine, UCSF. 1987-1988
Anesthesia Residency: UCSF, 1988-1991
Fellowship(s): UCSF, 1991-1992
Dr. Feiner studies:
Hypoxic ventilatory drive at altitude
Apnea with remifentanil and propofol
Transfusion Related Acute Lung Injury
Neuromonitoring in Spine Anesthesia
Pulse oximeter accuracy
Physiology of acute anemia
Predictors of kidney and liver donor organ function
M.D. or Ph.D. Institution: University of Chicago
Internship: University of Chicago
Anesthesia Residency: UCSF
M.D. or Ph.D. Institution: University of California, San Francisco
Internship: Internal Medicine, Kaiser Permanente Northern California
Anesthesia Residency: University of California, San Francisco
Home Town: Mumbai, India
M.D. or Ph.D. Institution: Mahatma Gandhi Mission's Medical College
Internship: Anesthesia, Seth GS Medical College and King Edward Medical College
Anesthesia Residency: University of South Florida
Anesthesia Residency: University of Western Ontario (UWO) and University of Toronto
Fellowship(s): Pulmonary research fellowship, Mayo Clinic
After a pulmonary research fellowship at Mayo with Kai Rehder, I returned to UWO in 1980 and split my time among the ICU, clinical anesthesia, and research. I was the Professor and Chair at UWO, 1990 – 2001 and moved to University of California San Francisco in 2004. My ICU and OR activity included a substantial contact with neurosurgical patients. My laboratory and clinical research activities have focused on the neurosciences especially cerebral blood flow and volume, neuromonitoring and ischemia.
Industry associations in the recent past:
Consultant and/or speaker: Wyeth, Merck, Abbott, Guilford, Hospira
Research contracts: GSK, Abbott, Xsira, J and J.
Honors and External Service:
International Anesthesia Research Society, Board of Trustees (Board Chair 2003/4)
Society of Neuroanesthesia and Critical Care Board of Directors (President 1996)
International Society for Anesthetic Pharmacology Board of Directors (President 2003/4)
Listed in Best Doctors in America
Listed in Best Doctors in Canada
Listed in International Who’s Who in Medicine
Canadian Anesthesiologists Society Research Recognition Award, 2000.
Dean’s Award of Excellence in Research and Teaching, University of Western Ontario 2000
Election to Fellowship, Royal College of Anaesthetists, UK, 2001
Society of Neuroanesthesia and Critical Care Distinguished Teacher Award 2003
Honorary Professor, Peking Union Medical College, Beijing, China (2005)
Visiting professorships and lectureships:
More than 200 world-wide; 11 Named Lectureships.
Dr. Gray has initiated several clinical trials to examine the role of nerve imaging for acute pain management interventions. Ultimately he hopes to improve nerve imaging with ultrasound to increase the efficacy and safety of peripheral nerve block procedures.
Dr Gregory studies the effects of resuscitation at birth on cerebral blood flow, volume, and oxygenation in preterm neonates. This is an important question because many neonates are born prematurely and there is a high instance of central nervous system injury in these patients, especially those born before 30 weeks gestation. Central nervous system injury is an important problem for the child, the family, and for society. These studies ask if the methods of resuscitation now in use in the delivery room have beneficial or detrimental effects. If they show the latter to be true, resuscitation methods can be altered to improve outcomes.
Director, Critical Care Medicine
Professor of Physiology
Associate Investigator, Cardiovascular Research Institute
M.D. or Ph.D. Institution: University of California Los Angeles
Internship: Internal Medicine, UCSF
Anesthesia Residency: UCSF
Fellowship(s): Critical Care Medicine, UCSF
Dr. Gropper is Professor of Anesthesia and Director of Critical Care Medicine at UCSF. He has a longstanding interest in improving outcomes in critically ill patients and has spearheaded successful efforts to reduce hospital-acquired infections in the ICU, especially catheter related bloodstream infections and ventilator associated pneumonia. His research interests are in the area of respiratory failure, severe sepsis, and transfusion medicine. He has received NIH funding for these projects.
Home Town: China
M.D. or Ph.D. Institution: Peking Union Medical College
Internship: Internal Medicine, Jersey Shore Medical Center
Anesthesia Residency: Massachusetts General Hospital
Fellowship(s): Pain Management, University of California, San Francisco
M.D. or Ph.D. Institution: Gifu University, Japan
Internship: Chestnut Hill Hospital, Philadelphia, PA
Anesthesia Residency: Columbia Presbyterian Medical Center (Columbia University), New York, NY
Fellowship(s): Columbia Presbyterian Medical Center (Columbia University), New York, NY
University of California, San Francisco
Dr. Hashimoto studies the roles of angiogenesis and vascular remodeling in vascular diseases including intracranial aneurysms, aortic aneurysms, and brain arteriovenous malformations. He is working to identify new therapeutic targets that induce stabilization and regression of vascular lesions.
M.D. or Ph.D. Institution: Columbia University College of Physicians and Surgeons
Internship: Oregon Health Sciences University
Anesthesia Residency: Massachusetts General Hospital
Fellowship(s): Massachusetts General Hospital (Critical Care Medicine)
I am an Critical Care Anesthesiologist and I do basic science research on mechanisms of sepsis. My primary clinical commitment is as an attending physician in the Intensive Care Units at UCSF Medical Center. I attend in the ICU 6-8 weeks per year.
My research interest in sepsis is very closely linked to my clinical interest in intensive care medicine. My laboratory investigates the basic mechanisms by which interactions between microorganisms and the host innate immune system ultimately lead to shock and organ dysfunction in sepsis. Toll-like receptors (TLRs) are innate immune receptors that recognize components of microorganisms and are critical in generating early inflammatory responses to infections. We previously found that different TLR agonists are shed by bacteria into the blood in sepsis models, including endotoxin, a TLR4 agonist, and PAL and MLP, TLR2 agonists. Subsequently we found that PAL and other TLR2 agonists activate endothelial cells, modulate expression of coagulation pathway factors in vitro and in vivo, induce lung and myocardial inflammation, and cause pulmonary dysfunction. We are currently investigating the underlying mechanisms and functional significance of TLR2 activation in sepsis in vivo using infection and toxicity models, and in vitro using endothelial cells and macrophages. We are focused on the effects of TLR2 pathways on coagulopathy, on the microvascular circulation, and on the lung. Recently we have found that different TLR agonists profoundly modulate inflammatory effects of one another, and we are pursuing studies to try to understand the mechanisms that underlie these "TLR interactions".
M.D. or Ph.D. Institution: Tulane Medical School, New Orleans, Louisiana
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Pain Management, University of California, San Francisco
Dr. Henry's clinical responsibilities will be at UCSF-Mt. Zion and the Pain Management Clinic.
Staff Anesthesiologist, San Francisco VA Medical Center
M.D. or Ph.D. Institution: Ludwig Maximilians Universitaet Muenchen, Germany
Internship: University of Washington, Seattle, Boise track
Anesthesia Residency: UCSF Department of Anesthesia
Fellowship(s): Cardiovascular Research Institute, UCSF
Jan Hirsch, MD
Staff Anesthesiologist
San Francisco VA Medical Center
University of California, San Francisco
Assistant Professor in Residence, Department of Anesthesia and Perioperative Care
VA Mail 129
4150 Clement Street
San Francsco, CA 94121
hirschj@anesthesia.ucsf.edu
Clinical Training
University of California, San Francisco.
Residency in the Department of Anesthesia and Perioperative Medicine, University of California, San Francisco (2005-2008)
University of Washington
Internship at the Medical Service, Boise VA Medical Center, Boise, ID (2004-2005)
Justus Liebig University, Giessen, Germany.
Residency (“Assistenzarzt”) at the Department of Anesthesiology and Intensive Care Medicine, Giessen University Hospital, Giessen, Germany (2000-2002)
Free University Berlin, Germany.
Residency (“Assistenzarzt”) in the Department of Anesthesiology and Intensive Care Medicine of the Unfallkrankenhaus (trauma center) Berlin, teaching hospital of the Free University Berlin, Germany (1997-2000)
Ludwig-Maximilians-University, Munich, Germany.
Internship (“Arzt im Praktikum”) in the Department of Internal Medicine I (Cardiology and Pulmonary), Klinikum Grosshadern (1995-1997)
Research Training
Cardiovascular Research Institute, University of California, San Francisco.
Postdoctoral Fellow in the laboratories of Michael A. Matthay, MD, Cardiovascular Research Institute, University of California, San Francisco. Supported by a grant of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) (2002-2004)
Ludwig-Maximilians-University, Munich, Germany.
Before and during residency (“AIP”) in the laboratories of Professor C. Vogelmeier, MD, Pulmonary Branch, Department of Internal Medicine I. Supported by a grant of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) (1994-1997)
Doctoral Thesis:
Ludwig-Maximilians-University, Munich, Germany, 2000: „Charakterisierung des Proteasen-Antiproteasensystems der transplantierten Lunge“ [Characterization of the protease-antiprotease system of the transplanted lung]
(summa cum laude)
Education
Ludwig-Maximilians-University, Munich, Germany.
Study of Medicine (1988-1994)
Publications
Doctoral Thesis:
Pulmonary Branch, Department of Internal Medicine I, Ludwig-Maximilians-University, Munich, Germany, 2000:
„Charakterisierung des Proteasen-Antiproteasensystems der transplantierten Lunge“
[Characterization of the protease-antiprotease system of the transplanted lung](summa cum laude)
Original Publications:
1. Hirsch J, Elssner A, Mazur G, Maier KL, Bittmann I, Behr J, Schwaiblmair M, Reichenspurner H, Fürst H, Briegel J and Vogelmeier C. Bronchiolitis Obliterans Syndrome after (Heart-) Lung Transplantation: Impaired Antiprotease Defense and Increased Oxidant Activity. AJRCCM 160(5): 1640-6, 1999.
2. Schaffartzik W, Hirsch J, Frickmann F, Kuhly P and Ernst A. Hearing Loss after Spinal and General Anesthesia: A Comparative Study. Anesth Analg 91(6): 1466-72, 2000.
3. Hirsch J, Wendt T, Sanft C and Schaffartzik W. Point-Of-Care measurement of coagulation. Anaesthesia 56(8): 760-3, 2001.
4. Hirsch J, Führer I, Kuhly P and Schaffartzik W. Preoxygenation: A comparison of three different breathing systems. Br J Anaesth 87 (12): 928-31, 2001.
5. Hirsch J, Bach R, Menzebach A, Welters ID, Dietrich GV and Hempelmann G. Temperature course and distribution during plasma heating with a microwave device. Anaesthesia 58(5):444-7, 2003.
6. Hirsch J, Menzebach A, Welters ID, Dietrich GV, Katz N and Hempelmann G. Indicators for erythrocyte damage after microwave warming of packed red blood cells. Clin Chem 49(5): 792-9, 2003.
7. Hansen KC, Schmitt-Ulms G, Chalkley RJ, Hirsch J, Baldwin MA and Burlingame AL. Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-ICAT and multi-dimensional chromatography. Mol Cell Proteomics: 2(5): 299-314, 2003.
8. Menzebach A, Hirsch J, Hempelmann G and Welters ID. Effects of Endogenous and Synthetic Opioid Peptides on Neutrophil Function in vitro. Br J Anaesth 91(4): 546-50, 2003.
9. Hirsch J, Hansen KC, Frank JA, Fang X, Chalkley RJ, Burlingame AL and Matthay MA. [Changes in the proteome of alveolar type II epithelial cells after high tidal volume ventilation]. Anaesthesiol Intensivmed, 44(11): 765, 2003.
10. Menzebach A, Hirsch J, Nost R, Mogk M, Hempelmann G, Welters ID. [Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependant mechanism]. Anasthesiol Intensivmed Notfallmed Schmerzther 39(4): 204-11, 2004.
11. X. Fang, Y.Song, R. Zemans, J. Hirsch and M.A. Matthay. Fluid transport across cultured rat and human alveolar epithelial cells: A novel in vitro system. Am J Physiol Lung Cell Mol Physiol. Jul;287(1):L104, 2004
12. I. D. Welters, J. Hirsch, A .Menzebach, G. Hempelmann, and M. Muller. [Activation of Granulocytes and Antiproteases in Open Heart Surgery with extracorporeal circulation.] Anasthesiol Intensivmed Notfallmed Schmerzther 40(3): P. 164, 2005.
13. X. Fang, Y. Song, J. Hirsch, L. J.V. Galietta, N. Pedemonte, R. Zemans, G. Dolganov, A.S. Verkman and M. A. Matthay. “Contribution of CFTR to Vectorial Fluid Transport in Cultured Human Alveolar Epithelial Type II Cells. Am J Physiol Lung Cell Mol Physiol.290(2):L242, 2006
14. J. Hirsch, K. C. Hansen, S. Choi, J. Noh, R. Hirose, J. P. Roberts, J. J. Maher, A. L. Burlingame, M. A. Matthay and C. U. Niemann. Changes in the proteome of hepatic Kupffer cells after warm ischemia quantified by ITRAQ labeling in rats. Molecular and Cellular Proteomics 2006 Jun;5(6):979-86; [Feb 24 epub ahead of print]
15. J. Hirsch, K. C. Hansen, J. A. Frank, R. J. Chalkley, X. Fang, J. C. Trinidad, P. Baker, A. L. Burlingame and M.A. Matthay “Impact of Low and High Tidal Volumes on the Rat Alveolar Epithelial Type II Cell Proteome.” Am J Respir Crit Care Med. 2007 May 15;175(10):1006-13. Epub 2007 Mar 15
16. J. Hirsch, C. U. Niemann, K. C. Hansen, X. Su, S. Choi, J. A. Frank, X. Fang, R. Hirose, P Theodore, A. Sapru, A. L. Burlingame, and M.A. Matthay. „Alterations in the Proteome of Pulmonary Alveolar Type II Cells in the Rat after Liver Ischemia”. Crit Care Med. 2008 Jun;36(6):1846-54
17. V. Minville, A. Gendre, J. Hirsch, S. Silva, B. Bourdet, C. Barbero, O. Fourcade, K. Samii, H. Bouaziz. The efficacy of skin temperature for block assessment after infraclavicular brachial plexus block. Anesth Analg. 2009 Mar;108(3):1034-6.
Review articles:
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie Vol 37(3), March 2002, P. 163-73
E. Seidelmayer-Grimm, J. Hirsch and G. Hempelmann
„Anästhesie für Patienten mit Mucoviscidose“
[Anesthesia in patients with cystic fibrosis]
J. Hirsch, K.C. Hansen, A.L. Burlingame and M.A. Matthay “Proteomics: Potential Applications to Lung Diseases”. Am J Physiol Lung Cell Mol Physiol ; Vol. 287 , July 1st 2004, P.1
Book sections:
G. Hempelmann, J. Hirsch and H. Neuhof
“Kreislaufphysiologische Grundlagen” [Background in cardiovascular physiology]
in ”Transfusionsmedizin Grundlagen - Therapie - Methodik “
[Transfusion Medicine Basics – Therapy- Methods]
Mueller-Eckhardt, C.; Kiefel, Volker (Eds.), 3rd edition, 2004, Springer-Verlag, Berlin, Heidelberg, New York,
J. Hirsch, L.B. Ware and M.A. Matthay
“Pulmonary Proteomics”
in “Clinical Proteomics: From Diagnosis to Therapy”
Van Eyk, J. and Dunn, M. (Eds.), Wiley Publishers, Weinheim, 2007
M.D. or Ph.D. Institution: University of Chicago
Internship: Resurrection Medical Center
Anesthesia Residency: UCSF
My laboratory is interested in developing isoform-selective inhibitors of phosphoinositide-3-kinase (PI3K) that target the innate immune system. These agents influence both endothelial permeability and neutrophil function, making them useful in studies of acute inflammation. In addition, these agents have the potential as therapies for the reduction of reperfusion injury after myocardial ischemia, cerebral ischemia and trauma.
M.D. or Ph.D. Institution: UCSF
Internship: California Pacific Medical Center
Anesthesia Residency: UCSF
M.D. or Ph.D. Institution: Mount Sinai School of Medicine
Internship: Maimonides Medical Center
Anesthesia Residency: Brigham and Women’s Hospital
M.D. or Ph.D. Institution: Harvard Medical School Boston, Massachusetts
Anesthesia Residency: Massachusetts General Hospital Boston, Massachusetts
Fellowship(s): Cardiothoracic Anesthesia, Emory University. Atlanta, Georgia
Dr. Joshi's clinical responsibilities, in view of his formal Cardiothoracic training, are at the Moffitt-Long Hospital, with significant involvement with "complex" cardiac, vascular, and thoracic cases, including those involving extracorporeal cardiorespiratory support. In addition, he is involved in the instruction of transesopahgeal echocardiography (TEE) for participating resdients and fellows.
Dr. Joshi's research include studying protein structure/function and the development of macromolecular inhibitors of proteases involved in contact activation, coagulation, and fibrinolysis.
Dr. Kim is a genetic epidemiologist working at the Center for Cerebrovascular Research. She is investigating genetic and environmental factors that predict hemorrhagic stroke and/or poor outcome in patients with cerebral vascular malformations.
M.D. or Ph.D. Institution: University of the Ryukyus School of Medicine
Okinawa, Japan
Internship: United States Naval Hospital, Okinawa, Japan
Medicine/Pediatrics, University of Texas, Houston, Texas
Fellowship(s): Clinical Pain
University of California, Davis, California
M.D. or Ph.D. Institution: Johann W Goethe University Frankfurt, Germany
Anesthesia Residency: Department of Anesthesia and Intensive Care, University of Cologne, Germany
Fellowship(s): Transfusion Medicine, University of Cologne, Germany
Dr. Krombach joined UCSF in 2002. Following a two-year visiting faculty position, he became a full-time faculty member in 2004. His clinical responsibilities are entirely at San Francisco General Hospital. In 2006, Dr. Krombach was appointed Anesthesia Clinical Director at SFGH. Dr Krombach has been instrumental helping to improve teaching both anesthesia residents and medical students while they are at SFGH. Currently, Dr. Krombach focuses on patient safety in the perioperative period. His research involves studying the safety and clinical effectiveness of ultrasound guided regional anesthesia.
M.D. or Ph.D. Institution: Victor Segalen Bordeaux II
University
Internship: Victor Segalen Bordeaux II
University
Anesthesia Residency: University Hospital of Fort de France
Fellowship(s): University Hospital of Bordeaux, SAR 2, Hopital Haut Leveque
M.D. or Ph.D. Institution: Dartmouth Medical School
Internship: Yale New Haven Hospital, Yale University School of Medicine
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Pulmonary and Critical Care Medicine Yale University School of Medicine
Dr. Larson, in collaboration with Dr. Niemann, investigates the interaction of the anti-fungal agent fluconazole on the pharmacodynamics of intravenous fentanyl in old and young patients.
Dr. Lee works in the Center for Cerebrovascular Research where she investigates the mechanisms of key pathways on cerebral angiogenesis and vascular malformations using pharmacological and genetic manipulations.
Director, Pain Management Center
Director, Pain Management Fellowship Program
M.D. or Ph.D. Institution: University of Chicago Pritzker School of Medicine
M.D. or Ph.D. Institution: University of Chicago Pritzker School of Medicine
Internship: University of Massachusetts Medical School
Anesthesia Residency: Beth Israel Deaconess Medical Center (Boston)
Fellowship(s): Boston Children's Hospital
The main focus of my research is understanding the potential therapeutic role of allogeneic human mesenchymal stem cells in acute lung injury. To study this, I have developed three human models: (1) A fairly novel ex vivo perfused human lung injured by E. Coli endotoxin. (2 & 3) Primary cultures of both human alveolar epithelial type II cells and human lung microvascular endothelial cells grown on Transwell plates injured by an inflammatory insult.
M.D. or Ph.D. Institution: Stanford University
Anesthesia Residency: UCSF
Fellowship(s): Cardiac Research
Dr. Leung investigates methods to improve perioperative care delivery and outcomes of elderly surgical patients. Examples of ongoing projects include investigation of left atrial remodeling and postoperative atrial fibrillation in patients undergoing open heart surgery, clinical trials on postoperative delirium and investigations of the mechanisms of heart failure in geriatric surgical patients.
Director, Spine Anesthesia Service
M.D. or Ph.D. Institution: UCSF
Internship: UCSF - general surgery
Anesthesia Residency: UCSF
Fellowship(s): UCSF - Critical Care Medicine
Dr. Lieberman studies:
1. Transfusion Related Acute Lung Injury
2. Anesthetic agent effects on Motor Evoked Potentials (MEP) and Somatosensory Evoked Potentials (SSEP)
3. Detection of Spinal Nerve Root Injury
4. Effect of Dexmedetomidine on MEP Responses
5. Effect of Hemodynamic Changes on MEP Responses
M.D. or Ph.D. Institution: Stanford University School of Medicine.
Internship: Santa Clara Valley Medical Center.
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Critical Care Fellowship, University of California, San Francisco
Dr. Lin spends the majority of his time as an attending anesthesiologist in the operating rooms at San Francisco General Hospital. He also serves as an attending physician in the intensive care units of San Francisco General and Moffitt-Long Hospitals.
M.D. or Ph.D. Institution: University of Miami
Anesthesia Residency: University of California, San Francisco
Dr. Litt uses ex vivo rat brain slices to investigate how intracellular energy metabolism of neurons and glia relates to brain injury and protection during hypoxia and ischemia. Mitochondria send out signals to start and stop apoptosis and necrosis. 31P, 13C, and 1H NMR spectroscopy at 14 Tesla are used to track metabolite changes. Mitochondrial signals associated with injury and repair are detected from changes in proteins, their phosphorylation, and also from redox states. Studies are done in whole slices, slice extracts, and cell fractions obtained with differential centrifugation. Cell biology techniques include Western blotting, immunohistology, in situ hybridization, and fluorescence microscopy.
Dr. Lobo does research in:
1. Spinal Cord Function During Endovascular Repair Of Thoracic Aortic Aneurysms
2. Dexmedetomadine in the Perioperative Care of Morbid Obese Patients Undergoing Bariatric Surgery
3. Pre-emptive analgesia in the Perioperative care of morbidly obese patients
M.D. or Ph.D. Institution: New York Medical College
Internship: New York Medical College, NYC, NY
Anesthesia Residency: University of California, San Francisco
Fellowship(s): University of California, San Francisco
Dr. London analyzes the efficacy and effectiveness of various perioperative therapies and procedures in high risk patients undergoing vascular and cardiac surgery, including beta blockade, pulmonary artery catheterization, transesophageal echocardiography, and early extubation in large patients cohorts in the Department of Veterans Affairs using clinical databases.
Dr. Marks investigates the mechanisms of botulism toxicity and produces human antibodies that block botulism toxicity.
Chairman
Dr. Eshima-McKay designs and conducts clinical studies related to 1) respiratory complications in patients undergoing anesthesia where an LMA is used for airway management; 2) respiratory complications and recovery of cognition and return to functional activities after anesthesia in smokers; 3) temporal recovery of protective airway reflexes after anesthesia in relation to awakening; 4) the effect of body mass index (BMI) on recovery from inhaled anesthetics of differing solubility in tissues (sevoflurane versus desflurane). Another project planned for Summer 2005 is an industry sponsored multicenter trial on the safety and efficacy of the oral neurokinin inhibitor GW679769 in prevention of nausea and vomiting after surgery.
Department Chairman
Professor of Cellular and Molecular Pharmacology
Dr. Miller's research has been in neuromuscular pharmacology and blood products. He is on the editorial board of the British Journal of Anesthesia. He edits a two-volume anesthesia text. Recently, he was elected to the Institute of Medicine, part of the National Academy of Sciences.
M.D. or Ph.D. Institution: Northeastern Ohio Universities College of Medicine
Anesthesia Residency: Cleveland Clinic Foundation in Cleveland, Ohio
Fellowship(s): Cardiothoracic Anesthesia, Emory University, Atlanta, Georgia
Dr. Mummaneni works exclusively at Moffitt-Long.
M.D. or Ph.D. Institution: University of California, San Francisco
Anesthesia Residency: Department of Anesthesia and Perioperative Care, University of California, San Francisco
Dr. Navarro joined the UCSF Anesthesia Faculty in 1990, and is currently a Professor of Anesthesia and Perioperative Care. Dr. Navarro is an Associate Dean of Academic Affairs in the School of Medicine and an Anesthesia Career Advisor. Dr. Navarro became the first UCSF Director of Academic Diversity, September 1, 2007. In her role, she is charged with coordinating the University’s Strategic Goal of Enhancing Diversity of faculty, students, trainees and staff.
Dr. Navarro's clinical practice is at San Francisco General Hospital. Dr. Navarro is a steering committee member of the African American Health Initiative for San Francisco County, and a member of the UC President’s Task Force on Faculty Diversity. Dr. Navarro's service to the University and the community has been honored by receipt of the Alpha Omega Alpha award, Chancellor’s Celebration of Women Faculty, Chancellor’s Martin Luther King Award, Elliott Rapaport Award, and former Mayor Willie Brown’s Proclamation of Dr. J. Renee Navarro Day in San Francisco.
M.D. or Ph.D. Institution: University of Western Australia
Internship: Medicine, Sir Charles Gairdner Hospital, Perth; Royal North Shore Hospital, Sydney
Anesthesia Residency: Royal Perth Hospital; Sir Charles Gairdner Hospital, Perth; King Edward Memorial Hospital, Perth; Royal Prince Alfred Hospital, Sydney
Associate Professor of Surgery
Dr. Niemann investigates ischemia/reperfusion injury in organ transplantation. He also evaluates liver function and splanchnic hemodynamics in liver transplant patients and in living liver donors.
M.D. or Ph.D. Institution: University of California, San Francisco School of Medicine
Internship: Medicine
San Francisco General Hospital
San Francisco, California
Anesthesia Residency: University of California, San Francisco
San Francisco, California
Director, UCSF PainCARE (Center for Advanced Research and Education)
Dr. Palmer investigates two receptor systems, the 5-HT receptors and the novel ORL1 (Opioid receptor-like) receptor and their involvement in peripheral mechanisms of nociception and inflammation.
Sol Shnider Endowed Chair for Anesthesia Education
Vice Chair for Education
Residency Program Director
M.D. or Ph.D. Institution: UCLA School of Medicine
Internship: Cedars Sinai Medical Center, Los Angeles
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Critical Care Medicine, University of California, San Francisco
Dr. Pardo serves in many educational roles in the department and on campus. He is the Anesthesia Residency Program Director, a position that began in September 2009 after several years as Associate Program Director. Since 1999, he has been the Director of the Anesthesia Patient Simulator Program. Other roles in the department include co-directing the Faculty Development Workshops. Dr. Pardo is a founding member of the UCSF Haile T. Debas Academy of Medical Educators. He holds the Sol Shnider Endowed Chair for Anesthesia Education, serving as a liaison between the Academy and the department. Since 2007, Dr. Pardo has also served as the interim director of the UCSF School of Medicine Kanbar Simulator Center, and has helped to expand the role of simulation in the training programs of the four major health profession schools at UCSF.
Dr. Pardo's clinical practice at UCSF Medical Center includes critical care medicine and anesthesia for liver transplantation.
M.D. or Ph.D. Institution: Mount Sinai School of Medicine New York, New York
Internship: Winthrop-University Hospital Mineola, New York
Anesthesia Residency: Massachusetts General Hospital Boston, Massachusetts
Fellowship(s): UCSF Pain Management Center San Francisco, California
My clinical time is divided between the UCSF Pain Management Center and the main O.R., both at the Mt. Zion Hospital campus. I am also currently the director of the resident and medical student rotations at the Pain Management Center.
M.D. or Ph.D. Institution: UCSF Program in Biomedical Sciences
Postdoctoral Training: UCSF Liver Center, CVRI and Institute for Human Genetics
Dr. Pawlikowska is an Assistant Professor in the Department of Anesthesia and Perioperative Care. Her research focus is genetic association studies of common human disease of complex inheritance, including cardiovascular phenotypes and longevity. In collaboration with Drs. William Young and Helen Kim, she studies the genetics of vascular phenotypes, focusing on brain arteriovenous malformation (BAVM), an important cause of stroke in young adults. Candidate-gene approaches have yielded several variants associated with BAVM incidence or clinical course; genome-wide association studies (GWAS) are underway. Other approaches planned include mapping modifier loci for angiogenesis in mice, screening for rare variants using high throughput sequencing technologies, and investigation of somatic genetic variation in BAVM tissue samples.
A second focus of Dr. Pawlikowska's research is on genetics of human aging and longevity. She is part of the NIA-funded Longevity Consortium. She has been involved in quantitative trait locus mapping in a long-lived mouse strain and in candidate-gene studies of human longevity including the insulin-IGF signaling pathway. Future projects include high-throughput sequencing to discover rare variants in genes in longevity-associated pathways.
Third, Dr. Pawlikowska is developing a research program in admixture mapping of cardiovascular disease traits in admixed populations such as African Americans. She is the principal investigator on an R01 proposal to map metabolic syndrome traits, funded by the NIDDK.
M.D. or Ph.D. Institution: Temple University, School of Medicine, at Philadelphia, Pennsylvania
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Pain Management, University of California, San Francisco
Dr. Pham's clinical responsibilities will be at the UCSF-Mt. Zion campus and the Pain Management Clinic.
Jean Francois Pittet, M.D, is Professor in Residence in the Departments of Anesthesia and Surgery. His research interests are:
1. Heat Shock and Lung Fluid Balance. The goal of this research project is to determine how the activation of the stress protein response (SPR) protects the integrity of the alveolar capillary barrier in acute lung injury (ALI). We developed a rodent model of ischemia-reperfusion (I/R)-mediated lung injury as a clinically relevant model of ALI. Indeed, SPR could be activated as early prophylactic therapy against I/R lung injury using pharmacologic agents that are safe in humans. This research project tests the hypothesis that the SPR activation protects the integrity of the alveolar capillary barrier by: (a) first by an immediate dissociation of Hsp90 from its clients proteins rendering these proteins nonfunctional, then (b) by a delayed phase involving de novo synthesis of heat shock proteins, such as Hsp70, that bind to Hsp90 client proteins rescuing these proteins from proteasomal degradation until the Hsp90 can re-complex with the proteins.
2. TGF-beta and alveolar epithelial injury. Acute Lung Injury (ALI) is a devastating syndrome with a mortality rate of 30-40 percent. Alveolar epithelial damage is a characteristic morphologic feature in patients with ALI. The loss of epithelial integrity contributes to the alveolar flooding and disrupts normal lung epithelial fluid transport that is important for the removal of pulmonary edema fluid from the airspaces. The molecular steps regulating the development and resolution of alveolar flooding in ALI are poorly understood. The cytokine transforming growth factor beta 1 plays a critical role in the development of ALI and lung fibrosis that is often associated with this syndrome. Thus, this research project tests the hypothesis that locally activated TGF-beta 1 decreases basal and c-AMP regulated lung epithelial fluid transport by altering the expression and function of both the amiloride-sensitive sodium channel ENaC, and the chloride channel CFTR on the cell membrane of lung epithelial cells, thus inhibiting the removal of pulmonoary edema from the airspaces in acute lung injury.
3. Coagulopathy and Trauma. Trauma remains the leading cause of death and disability in patients less than 40 years old, eclipsing ischemic heart disease, stroke and HIV/AIDS. Coagulopathy is common following severe trauma and is associated with poor outcome. Classically, traumatic coagulopathy has been shown to be caused by acidosis and hypothermic inhibition of clot formation as well as dilution of coagulation factors from intravenous fluid therapy. However, recent studies from our laboratory have reported that one quarter of major trauma patients are coagulopathic upon arrival in the emergency department before any fluid resuscitation. This coagulopathy was dependent on concomitant hypoperfusion and hence unlikely to be exclusively due to tissue injury and coagulation factor consumption. Despite the understanding of a strong link between injury, hypoperfusion and bleeding, the mechanisms for hypoperfusion-induced coagulopathy after trauma are unknown. Thus, this research project tests the hypothesis that (a) acute traumatic coagulopathy is primarily caused by tissue hypoperfusion resulting in a complement-mediated activation of the protein C pathway and (b) posttraumatic coagulation abnormalities increase the damage to the lung endothelial barrier caused by P. aeruginosa, one of the most common cause of nosocomial pneumonia in ICU patients.
M.D. or Ph.D. Institution: New York University School of Medicine
Internship: Santa Clara Valley Medical Center
Anesthesia Residency: University of California San Francisco
Arun Prakash was born and grew up in Kuwait and completed his schooling in Bangalore, India before moving to the United States in 1992 to pursue his higher education at the University of Rochester in upstate New York. After receiving a B.S in Chemistry and a B.A. in History, he moved to New York University in 1996 to join the MD-PhD program there. At NYU, he completed his doctoral thesis studies in the department of Molecular Immunology focusing on the role and regulation of type I Interferons in the anti-viral response in 2003. After completing medical school, he moved to California to begin his postgraduate education in 2005, first at Santa Clara Valley Medical Center in San Jose for a preliminary internal medicine internship and, then in 2006, at UCSF in the department of anesthesia and perioperative care. He graduated from the anesthesia residency program in June 2009 and has joined the faculty at UCSF with his clinical duties primarily at San Francisco General Hospital. His research activities include trying to understand the molecular mechanisms behind lung reperfusion injury with a special focus on the innate immune system.
M.D. or Ph.D. Institution: Georgetown University School of Medicine
Internship: Pediatrics, University of California, San Francisco
Anesthesia Residency: Pediatrics and Anesthesia, University of California, San Francisco
Fellowship(s): Pediatric Pulmonology and Pediatric Anesthesia, University of California, San Francisco
M.D. or Ph.D. Institution: University of Minnesota Medical School
Minneapolis, MN
Internship: Combined Plastic and General Surgery
University of Pittsburgh Medical Center
Pittsburgh, PA
Anesthesia Residency: UCSF Department of Anesthesia & Perioperative Care
Dr. Rollins investigates means of improving oxygen delivery both to acute wounds (e.g., maintaining normothermia and administering 100 percent oxygen intraoperatively) and to chronic wounds (e.g., sympathetic blockade, local warming and hyperbaric oxygen therapy). This involves studies in animal models, human volunteers, and patients, along with developing better oxygen measuring techniques.
Professor of Clinical Obstetrics, Gynecology and Reproductive Sciences
Director, Obstetric Anesthesia
M.D. or Ph.D. Institution: University of California San Francisco
Internship: University of California San Francisco
Anesthesia Residency: University of California San Francisco
Fellowship(s): University of California San Francisco
Clinical career focused on obstetric anesthesia, anesthesia during pregnancy and anesthesia for fetal surgery.
M.D. or Ph.D. Institution: University of Pennsylvania School of Medicine
Anesthesia Residency: Hospital of the University of Pennsylvania
Medical Director, Mt Zion and Parnassus Prepare Clinic
M.D. or Ph.D. Institution: Oregon Health and Science University, Portland, Oregon
Internship: Internal medicine, Kaiser Foundation Hospitals
Anesthesia Residency: University of California, San Francisco.
Fellowship(s): Pediatric and Adult Cardiac Anesthesia and Transesophageal Echocardiography, University of California, San Francisco
Dr. Rouine-Rapp is a medical director of the Mt Zion and Parnassus Prepare clinics where patients undergo medical evaluation and perioperative risk assessment prior to surgery. In the operating room, Dr. Rouine-Rapp is a member of the cardiac anesthesia team. She delivers anesthetic care to adult and pediatric patients who undergo surgery for acquired or congenital heart disease. In addition, she cares for adult patients who undergo heart or lung transplants.
Dr. Rouine-Rapp has participated in the Teaching Scholars Program and for several years was the Course Director of a clerkship for medical students, the Perioperative Care Clerkship (Anesthesia 140.09). Dr. Rouine-Rapp received the William K Hamilton teaching award from the anesthesia residents in 2000.
M.D. or Ph.D. Institution: Hannover Medical School, Germany
Anesthesia Residency: Hannover Medical School Hospital, Hannover, Germany
Fellowship(s): Emergency Medicine and Intensive Care Medicine, Hannover Medical School Hospital, Hannover, Germany
Before coming to the United States, Dr. Ruschulte was an Attending and later a Consultant Anesthesiologist in the Department of Anesthesiology, Hannover Medical School Hospital, Hannover, Germany. He has worked in student education and simulator training. He recently co-published a student pocket atlas about emergency medicine. Clinically he was involved as a supervisor in ambulatory anesthesia, surgical intensive care medicine and A and E Medical at Hannover Medical School Germany. One of his scientific interests is the prevention of catheter-related infections. At UCSF, Dr. Ruschulte's clinical responsibilities will be to provide anesthesia for patients having surgery at Moffitt/Long Hospital and the Mount Zion Hospital.
Dr. Russell focuses on intraoperative transesophageal echocardiography with particular interest in infants and children with congenital heart disease. In cardiac adult patients, current projects include the utility of myocardial contrast echocardiography via TEE as a novel approach to objectively analyze myocardial perfusion.
M.D. or Ph.D. Institution: University of Iowa College of Medicine
Internship: University of Iowa Hospitals and Clinics, Internal Medicine
Anesthesia Residency: University of California San Francisco
Fellowship(s): University of California San Francisco
Dr. Sall's research focus is in understanding how anesthetics impact neural development. Specifically, his group studies how anesthetics alter hippocampal cognitive function and neurogenesis in the hippocampus of neonates and adults.
Dr. Sall's clinical responsibilities are in the Moffit and Mt Zion OR's and on the obstetrical anesthesia service and Moffit.
M.D. or Ph.D. Institution: Paris Medical School,
University of Paris
Anesthesia Residency: University Hospitals of Paris
Fellowship(s): University Hospitals of Paris
Professor and Chairman: Bicetre University Hospital, Paris (1987-1999) and
Toulouse University Hospitals (1999-2008).
The main research interest of Kamran Samii is on clinical practice and safety of regional anesthesia. His is the editor of the French Anesthesia text book.
Dr. Schumacher investigates the structure, function and genomic regulation of ion channels that are activated by noxious stimuli. Through the study of the capsaicin receptor (TRPV1)(VR1) and its family of related ion channels, Dr. Schumacher and his lab hopes to one day develop a means to selectively block acute and chronic pain at the level of the peripheral sensory nerve terminal.
Dr. Schumacher's famous paper on capsaicin published in Nature.
M.D. or Ph.D. Institution: University of Hawaii, John A. Burns School of Medicine
Internship: University of Hawaii Transitional Internship Program
Anesthesia Residency: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital
M.D. or Ph.D. Institution: George Washington School of Medicine, Washington, D.C.
Internship: University of California, Davis-East Bay, California
Anesthesia Residency: University of California Los Angeles
Fellowship(s): Pediatric Anesthesia, Stanford University
Prior to arriving at the University of California, San Francisco, Dr. Shibata worked at University of California, Los Angeles. Dr. Shibaba will perform her clinical responsibilities at Moffitt-Long Hospital.
Associate Medical Director 9 & 13 ICU
M.D. or Ph.D. Institution: Faculty of Medicine, McGill University (Montreal, PQ, Canada)
Internship: NYU/Bellevue Hospital (NY, NY)
Anesthesia Residency: UCSF
Fellowship(s): Critical Care Medicine, UCSF
M.D. or Ph.D. Institution: Rheinisch-Westfaelischen Technischen Hochschule Aachen, Germany
Anesthesia Training: Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Germany
Fellowship: Cardiothoracic Anaesthesia at Papworth/Cambridge UK and Pediatric Anaesthesia, Starship Hospital, Auckland, New Zealand
Dr. Simon started at the San Franisco General Hospital as a visiting assistant professor in 2005 after having had anaesthesia training in Germany, UK and New Zealand. He is a clinical instructor and works on improving clinical efficiency and teaching (students, residents) at the San Francisco General Hospital.
M.D. or Ph.D. Institution: University of Melbourne Medical School
Internship: General Surgery/Medicine, St. Vincent's Hospital, Melbourne
Anesthesia Residency: St. Vincent's Hospital, Melbourne; Sunshine Hospital, Victoria; Monash Medical Center, Victoria
Fellowship(s): St. Vincent's Hospital, Melbourne
M.D. or Ph.D. Institution: Harvard Medical School
Internship: Medicine/UCSF
Anesthesia Residency: UCSF
Fellowship(s): UCSF (research fellowship with Ted Eger)
Dr. Sonner investigates the mechanism of inhjaled and injectable anesthetics. He studies anesthetic effect on expressed ion channels and in animals. His projects include: a gene mapping study in mice which differ in their anesthetic requirement; investigations on experimental anesthetics, including compounds elevated in metabolic comas, which are hypothesized to act as endogenous anesthetics; tests of the effect of anesthetics on memory and responses to pain in genetically modified mice, and parallel pharmacologic studies in rats; and he is beginning a project to develop a models for anesthetic effects in one-celled organisms.
M.D. or Ph.D. Institution: Free University, Berlin Germany
Anesthesia Residency: University of Illinois at Chicago
Fellowship(s): Critical Care, University of Miami
Cardio-thoracic, University of Illinois at Chicago
Dr Stechert's clinical practice includes critical care medicine and anesthesia for cardiac and thoracic surgery. His research interests are cardiothoracic anesthesia and intraoperative transesophageal echocardiography (TEE), in particular, its application in the ICU setting.
Dr. Stratmann and his group study the effects of anesthesia on neurogenesis. Neurogenesis is the formation of new neurons in the brain from stem cells. During development neurogenesis forms the brain. In adults neurogenesis contributes to mental health, as well as to learning and memory.
Anesthetic agents seem to affect neurogenesis differently depending on age. In young adult rats isoflurane increases neurogenesis but in neonatal and old adult rats stem cell proliferation is decreased by isoflurane.
We have three important overall goals:
1) To understand the mechanism of the action of isoflurane on neurogenesis
2) To study other anesthetic agents and to understand whether the age-related effect of anesthetic agents on neurogenesis is a pharmacologic phenomenon or a consequence of the state of anesthesia per se
3) To define which anesthetic regimen provides the best neurologic and neurocognitive outcome at different stages of life.
M.D. or Ph.D. Institution: Nanjing Medical University, P. R. China
Fellowship(s): University of California, San Francisco
Hua Su, MD
Dr. Su is interested in angiogenic gene and cell therapies for ischemic organs and tissues, and the mechanisms of angiogenesis. Her current research includes:
1. Developing strategies to treat brain ischemia by promoting functional angiogenesis and neurorestoration. Dr. Su is testing the feasibility of using adeno-associated viral vector (AAV) mediated hypoxia-inducible angiogenic gene expression to induce angiogenesis at ischemic core/penumbra of ischemic brain. Funded by a grant from the CIRM stem cell program and collaborating with Dr. Samuel Pleasure in the Dept. of Neurology, she is using human stem cell derived oligodendrocytes to regenerate injured brain. She is also collaborating with Dr. Fen-Biao Gao at Gladstone Research Institute, studying the roles of micro RNA in neuron stem cell differentiation, migration and in brain injuries
2. Studying the mechanisms of brain AVM pathogenesis and developing a clinically relevant model of brain arteriovenous malformation (AVM). The etiopathogenesis of brain AVM remains unknown and research progress is critically hampered by the lack of animal models. In collaboration with Dr. William Young and other scientists in the Center for Cerebrovascular Research, Dr. Su is using the following strategies to develop brain AVM model in the adult mouse: (1) genetic manipulation using transgenic or knockout mice; (2) block ligand-receptor binding by overexpression of soluble proteins; (3) focal angiogenic stimulation by AAV mediated VEGF gene transfer; and (4) altering hemodynamic forces in the brain by pharmacological manipulation or surgical creation of arteriovenous shunting.
M.D. or Ph.D. Institution: Georgetown University
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Critical Care, University of California, San Francisco
Dr. Sullivan also did a residency in internal medicine before deciding to pursue a career in anesthesia and critical care medicine. After finishing her critical care fellowship, Dr. Sullivan started on our faculty as a Clinical Instructor. She is currently an Assistant Clinical Professor with clinical responsibilities at the Moffitt-Long Hospital and Mount Zion.
Dr. Talke investigates the physiology and pharmacology of highly selective alpha-2 agonists in humans and in animals. He currently concentrates on the effect of different alpha-2b genotypes on vascular responsiveness in humans.
Medical Director, Critical Care Medicine Group
San Francisco General Hospital
He has also been the primary investigator of ICU clinical trials involving sedation, sublingual capnometry, and nosocomial pneumonia due to MRSA.
Dr. Taylor investigates the mechanism of action of nitrous oxide and the oxygen sensitivity of NMDA receptors. He utilizes oocyte and hippocampal slice techniques as well as the sensing of calcium currents using microscopic dye techniques.
Medical Director, Moffitt-Long Post Anesthesia Care Unit.
M.D. or Ph.D. Institution: Case Western Reserve University
Cleveland, OH
Internship: Internal Medicine
UCSF
Anesthesia Residency: UCSF Department of Anesthesia & Perioperative Care
Fellowship(s): Critical Care Medicine
UCSF
Dr. Taylor does his clinical work and teaching in the operating rooms and the critical care units at both Moffitt and Mount Zion Hospitals.
M.D. or Ph.D. Institution: University of Texas Southwestern at Dallas
Internship: Baylor University Medical Center
Anesthesia Residency: University of California San Francisco
Fellowship(s): Critical Care - University of California San Francisco
Dr. Thornton's clinical interests include critical care and cardiac, vascular, and thoracic anesthesia. His clinical responsibilities will be at Moffitt-Long and Mount Zion Hospitals.
Dr. Vale is Professor of Cellular and Molecular Pharmacology, Howard Hughes Investigator and also William K. Hamilton Distinguished Professor of Anesthesia. Dr. Vale is intimately involved in guiding basic science based research projects in the Anesthesia Department, and is a key advisor to the Program Director, the Department Chairman, the Anesthesia Research Faculty, and trainees. Dr. Vale leads a UCSF research program that combines cell biological and biophysical approaches to understand the cytoskeleton and more general issues on spatial organization and movement within cells. His laboratory relies heavily on microscopy, and uses a combination of biochemical, morphological and biophysical approaches. Specifically, recent investigations have focused on two motor proteins, kinesin and dynein, and their roles in organelle transport and mitosis. The lab is also studying the mechanism of other types of proteins, such as microtubule severing proteins, proteins that localize dynamically to growing plus ends of microtubules, and motor regulatory proteins.
Using a variety of in vitro motility assays as tools to study motor proteins, his studies seek to decipher how these proteins convert chemical energy derived from ATP hydrolysis into useful mechanical work, how motor proteins become attached to organelles, and how cells regulate the sorting and transport of organelles and mRNA using motors. The ability to engineer protein machines is extremely powerful for deciphering their mechanisms and learning more general lessons about protein design which could potentially be applies to protein therapeutics in vitro. The lab has also become interested in how signaling molecules are organized in the plasma membranes. Finally, at the top of the hierarchy of complexity, the lab has begun a project to look at the cell behavior during regeneration of tissues in Planarians (a flat worm with remarkable regenerative potential), an effort that will involve a considerable imaging component. Dr. Vale also uses a combination of genome-wide RNAi screening and high-resolution microscopy to identify new genes involved in the activities related to the cytoskeleton.
M.D. or Ph.D. Institution: Humboldt University Berlin Germany
Internship: University of Florida Gainesville FL
Anesthesia Residency: University of Florida Gainesville FL
Fellowship(s): University of California San Francisco CA, CT Anesthesia
M.D. or Ph.D. Institution: Johns Hopkins, Baltimore, Maryland
Internship: Unviersity of California, San Francisco Internal Medicine
Anesthesia Residency: University of California, San Francisco Anesthesiology
Fellowship(s): University of California, San Francisco Cardiac Anesthesiology
Art Wallace is an associate professor of anesthesiology and perioperative care at the University of California, San Francisco and an attending anesthesiologist at the Veterans Affairs Medical Center in San Francisco. His clinical practice includes cardiac and non-cardiac anesthesiology as well as ICU and preoperative clinical care. His research interests started with work on imaging myocardial infarctions with CT scanning. He completed a B.S. in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including both device development, surgical therapy of heart failure, and drug testing. He is most known for his work testing drugs for the prevention of perioperative cardiac morbidity and mortality. His present work includes development of a selective nitric oxide donor to reduce perioperative cardiac risk. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction.
Medical Director of Respiratory Care Services at San Francisco General Hospital
Director of Quality, San Francisco General Hospital Dept. of Anesthesia
Co-chair, Procedural Sedation Subcommitee of Pharmacy and Therapeutics at SFGH
M.D. or Ph.D. Institution: University of Texas, Southwestern Medical School
Internship: Virginia Mason Medical Center, Seattle, Washington
Anesthesia Residency: University of California, San Francisco
Fellowship(s): Critical Care, University of California, San Francisco
Dr. Wong received a B.S. from Stanford University and his M.D. from the University of Texas Southwestern Medical Center at Dallas. After completing his residency in Anesthesia at UCSF, he served as a Clinical Instructor in our Department. During 2006 he was a Critical Care Fellow with our Department.
Dr. Wong returned to the faculty as an Assistant Clinical Professor in January 2007 with clinical responsibilities at San Francisco General Hospital and Moffit/Long Hospital Intensive Care Units, as well as the SFGH operating rooms.
M.D. or Ph.D. Institution: Albany Medical School
Internship: Internal Medicine, Albany Medical Center
Anesthesia Residency: University of California, San Francisco
Director, ICU at Mount Zion Hospital
M.D. or Ph.D. Institution: University of California San Francisco
Internship: L.A. County - University of Southern California Medical Center
Anesthesia Residency: Harbor-U.C.L.A. Medical Center
Fellowship(s): University of Pittsburgh Department of Critical Care
Research: Dr. Yost has identified, and continues to investigate, a family of potassium channels that may play an important role in the mechanism of action of volatile anesthetics. He has published over 60 peer-reviewed journal articles relating to the molecular pharmacology of anesthetic drugs.
Clinical: Attending Anesthesiologist Moffitt-Long and Mt. Zion operating room specializing in anesthesia for liver transplants. He has attended on over 200 liver transplant cases since 1992. He has been Medical Director of the U.C.S.F Mt. Zion Intensive Care Unit since 2004.
M.D. or Ph.D. Institution: Indiana University
Internship: Bridgeport Hospital/ Yale University
Anesthesia Residency: New York University / Bellevue Hospital Center
Fellowship(s): The Neurological Institute of Columbia University
Postdoctoral Training: Columbia University College of Physicians & Surgeons
Dr. Young investigates the integrative physiology of the cerebral circulation with special reference to angiogenesis, brain vascular malformations and occlusive cerebrovascular disease. He also investigates the clinical physiology of systemic and cerebral circulatory manipulation during neuroanesthetic management.
